JP2011225475A - Muscle atrophy inhibitor and muscle growth promoter - Google Patents
Muscle atrophy inhibitor and muscle growth promoter Download PDFInfo
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- JP2011225475A JP2011225475A JP2010095373A JP2010095373A JP2011225475A JP 2011225475 A JP2011225475 A JP 2011225475A JP 2010095373 A JP2010095373 A JP 2010095373A JP 2010095373 A JP2010095373 A JP 2010095373A JP 2011225475 A JP2011225475 A JP 2011225475A
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Abstract
Description
本発明は、所定のミネラル成分を含有してなる筋萎縮抑制剤及び筋成長促進剤に関する。 The present invention relates to a muscle atrophy inhibitor and a muscle growth promoter containing a predetermined mineral component.
近年、発育期の子供、高齢者、スポーツ選手、女性向けにさまざまなサプリメントが開発され、販売されている。それらの用途は、ダイエット効果、老化防止、体力増強、筋力増加など様々である。サプリメントのなかでもスポーツ活動やトレーニング効果に対するアミノ酸やミネラル添加成分の影響に関する報告が数多い。それらの生理的・生化学的作用機序は十分に解明されていないが、確かな効果として位置づけられている。しかしながら、逆にこれら微量栄養素がスポーツ活動やトレーニング効果に影響がないとする報告もある。従って、実験条件を十分に吟味し効果の有無の背景を考察することが要求される。 In recent years, various supplements have been developed and sold for growing children, the elderly, athletes and women. There are various uses such as a diet effect, aging prevention, physical strength enhancement, and muscle strength increase. Among supplements, there are many reports on the effects of amino acid and mineral additives on sports activities and training effects. Their physiological and biochemical mechanisms of action have not been fully elucidated, but they are positioned as certain effects. However, there are reports that these micronutrients do not affect sports activities and training effects. Therefore, it is required to thoroughly examine the experimental conditions and consider the background of the effect.
一般的に、高齢者、リハビリ中の者、宇宙飛行士などには、不活動・廃用性の筋萎縮が認められる。このような筋萎縮は、筋力低下は勿論のこと、転倒骨折、呼吸機能の低下、循環機能の低下などの様々な疾病をもたらす。そこで、かかる筋萎縮の問題点に鑑み、本発明の目的は、筋萎縮の抑制効果と筋成長の促進効果のある新たなサプリメントを提供することにある。 In general, elderly, rehabilitating, and astronauts have inactive and disuse muscular atrophy. Such muscle atrophy causes various diseases such as falling fractures, decreased respiratory function, decreased circulatory function as well as decreased muscle strength. Then, in view of the problem of this muscular atrophy, the objective of this invention is providing the new supplement with the suppression effect of muscular atrophy and the promotion effect of muscle growth.
上述した目的は、ミネラル成分（リンを除く。）を含有する飲料水であって、重量配合比で、ナトリウムを8.3、カリウムを33.0、マグネシウムを3.1、カルシウムを3.8、鉄を0.30、亜鉛を0.09含有することを特徴とする筋萎縮抑制剤及び筋成長促進剤によって達成される。 The above-mentioned purpose is a drinking water containing mineral components (excluding phosphorus), and by weight ratio, sodium is 8.3, potassium is 33.0, magnesium is 3.1, calcium is 3.8, iron is 0.30, and zinc is 0.09. It is achieved by a muscle atrophy inhibitor and a muscle growth promoter characterized by containing.
上述したミネラル成分添加飲料水を摂取することにより、筋萎縮を抑制することができ、また筋成長を促進させることができる。したがって、これを継続して摂取することにより、例えば高齢者、リハビリ中の者、低体力の者、宇宙飛行士、寝たきり老人などの筋力低下を効果的に抑制することができる。 By ingesting the mineral component-added drinking water described above, muscle atrophy can be suppressed and muscle growth can be promoted. Therefore, by continuously ingesting this, it is possible to effectively suppress, for example, a decrease in muscle strength of an elderly person, a rehabilitated person, a person with low physical strength, an astronaut, a bedridden elderly person, and the like.
はじめに、本発明に係る筋萎縮抑制剤をなす飲料としてミネラル添加飲料水を調製した。ミネラル添加飲料水の成分を表１に示す。なお、表１に示すとおり、本発明をなすミネラル添加飲料水にはリンは添加されていない。 First, a mineral-added drinking water was prepared as a beverage forming the muscle atrophy inhibitor according to the present invention. Table 1 shows the components of mineral-added drinking water. In addition, as shown in Table 1, phosphorus is not added to the mineral addition drinking water which makes this invention.
続いて、上記ミネラル添加飲料水を摂取することによる廃用性筋萎縮に及ぼす影響を観察した。実験ではマウスを用い、ミネラル添加飲料水の効果を明らかにするために実験終了後、体重及び筋肉重量を測定した。実験方法の詳細は以下のとおりである。 Subsequently, the effect of ingesting the mineral-added drinking water on disuse muscle atrophy was observed. In the experiment, mice were used, and body weight and muscle weight were measured after the experiment to clarify the effect of mineral-added drinking water. The details of the experimental method are as follows.
［実験方法］
１）実験動物
生後６ヵ月以上経過し、成体に達したＤＤＹマウスの雄（体重46g±1g）を１５匹用意した。これらを３グループ（比較例群１、比較例群２、実施例群）に分け、各グループ５匹とした。
[experimental method]
1) Experimental animals Fifteen or more male DDY mice (body weight 46 g ± 1 g) that had reached 6 months of age and reached adulthood were prepared. These were divided into 3 groups (Comparative Example Group 1, Comparative Example Group 2, Example Group), and each group had 5 animals.
２−１）比較例群１
３グループのうち１グループを、通常状態（自由環境）で飼育する群とした。
このグループには、正起薬品工業社製・純水を飲料水として与えた。
飲料水は自由摂取とした。
2-1) Comparative example group 1
One of the three groups was a group reared in a normal state (free environment).
This group was given pure water from Seiki Pharmaceutical Co., Ltd. as drinking water.
Drinking water was ad libitum.
２−２）比較例群２
次の１グループを、尾懸垂する事によって後脚を無荷重状態にして廃用性筋萎縮を惹起させる群とした。
このグループには比較例群１と同じ純水を飲料水として与えた。
飲料水は自由摂取とした。
2-2) Comparative group 2
The next group was a group that caused disuse muscle atrophy by placing the rear legs in an unloaded state by hanging the tail.
The same pure water as Comparative Example Group 1 was given to this group as drinking water.
Drinking water was ad libitum.
２−３）実施例群
残りの１グループを、比較例群２と同様に、尾懸垂する事によって後脚を無荷重状態にして廃用性筋萎縮を惹起させる群とした。
このグループには、上記ミネラル添加飲料水を１０％濃度に希釈したものを与えた。
ミネラル添加飲料水は自由摂取とした。
2-3) Example group As with Comparative Example Group 2, the remaining one group was a group that caused disuse muscular atrophy by placing the rear legs in an unloaded state by hanging the tail.
This group was given a 10% strength dilution of the mineral-added drinking water.
Mineral-added drinking water was ad libitum.
３）飼料
各グループとも、飼料はオリエンタル酵母社のマウス・ラット飼料ＭＦを与え、自由摂取とした。飼料の成分を表２に示す。
3) Feed For each group, the feed was mouse / rat feed MF from Oriental Yeast Co., Ltd. Table 2 shows the ingredients of the feed.
４）飼育環境
各グループとも、室温26℃±１℃、湿度40％に制御された飼育室内にて飼育した。
4) Breeding environment Each group was raised in a breeding room controlled at room temperature 26 ° C ± 1 ° C and humidity 40%.
５）実験期間
実験期間は１週間とした。
5) Experiment period The experiment period was one week.
６）体重及び筋肉重量の計測
実験開始時と実験終了時に、電磁式秤（研精工業社製ＦＹ−3000）で全マウスの体重を測定した。
飼育期間終了後、各グループの全マウスを麻酔・安楽死させ、ヒラメ筋を丁寧に取り出し、電子天秤（メトラー社製ＡＧ−245)で測定した。
6) Measurement of body weight and muscle weight At the start and end of the experiment, the body weight of all mice was measured with an electromagnetic balance (FY-3000 manufactured by Kensei Kogyo Co., Ltd.).
After the breeding period, all mice of each group were anesthetized and euthanized, and the soleus was carefully taken out and measured with an electronic balance (AG-245 manufactured by METTLER).
［実験結果］
１）計測結果
体重及び筋肉重量の計測結果は、表３に示すとおりである。
なお、実験終了時の各群の平均体重差を考慮し、筋肉重量ではなく体重比で比較検討した。
[Experimental result]
1) Measurement results Table 3 shows the measurement results of body weight and muscle weight.
In addition, considering the average body weight difference of each group at the end of the experiment, a comparison was made based on body weight ratio, not muscle weight.
２）ミネラル添加飲料水のヒラメ筋（遅筋）に及ぼす影響について
図１に、本実験におけるヒラメ筋についての実験結果を示す。
通常飼育の比較例群１と比較して、筋萎縮惹起の比較例群２のヒラメ筋は、統計的に有意な減少（萎縮）が観察された。
しかしながら、ミネラル添加飲料水を与えた実施例群では、筋萎縮を惹起させたにもかかわらず、比較例群１と比較してヒラメ筋の値には差が観察されなかった。
また、比較例群２と実施例群を比較した場合においても、比較例群２のヒラメ筋は有意な減少（萎縮）が観察された。
2) Effect of Mineral-Adding Drinking Water on Soleus Muscle (Slow Muscle) FIG. 1 shows the experimental results of the soleus muscle in this experiment.
A statistically significant decrease (atrophy) was observed in the soleus muscle of Comparative Example Group 2 inducing muscle atrophy compared with Comparative Breeding Comparative Example Group 1.
However, in the example group to which the mineral-added drinking water was given, no difference was observed in the value of the soleus muscle as compared with the comparative example group 1 in spite of causing muscle atrophy.
In addition, when the comparative example group 2 and the example group were compared, a significant decrease (atrophy) was observed in the soleus muscle of the comparative example group 2.
［ミネラル添加飲料水の効果］
上述した実験結果より、本発明をなすミネラル添加飲料を与えることにより、筋萎縮を効果的に抑制できることが確認された。
[Effects of mineral-added drinking water]
From the experimental results described above, it was confirmed that muscle atrophy can be effectively suppressed by providing the mineral-added beverage according to the present invention.
Claims (2)
重量配合比で、ナトリウムを8.3、カリウムを33.0、マグネシウムを3.1、カルシウムを3.8、鉄を0.30、亜鉛を0.09含有することを特徴とする筋萎縮抑制剤。 A muscle atrophy inhibitor comprising drinking water containing mineral components (excluding phosphorus),
A muscle atrophy inhibitor containing 8.3 sodium, 33.0 potassium, 3.1 magnesium, 3.8 calcium, 0.30 iron, 0.30 iron, and 0.09 zinc in a weight ratio.
重量配合比で、ナトリウムを8.3、カリウムを33.0、マグネシウムを3.1、カルシウムを3.8、鉄を0.30、亜鉛を0.09含有することを特徴とする筋成長促進剤。 A muscle growth promoter comprising drinking water containing mineral components (excluding phosphorus),
A muscle growth promoter characterized by containing 8.3 sodium, 33.0 potassium, 3.1 magnesium, 3.8 calcium, 0.30 iron, 0.30 iron, and 0.09 zinc by weight.
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| JP2010095373A JP2011225475A (en) | 2010-04-16 | 2010-04-16 | Muscle atrophy inhibitor and muscle growth promoter |
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| JP2010095373A JP2011225475A (en) | 2010-04-16 | 2010-04-16 | Muscle atrophy inhibitor and muscle growth promoter |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014055905A1 (en) * | 2012-10-04 | 2014-04-10 | Abbott Laboratories | Methods for enhancing the effect of egcg on mitigating skeletal muscle loss |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014055905A1 (en) * | 2012-10-04 | 2014-04-10 | Abbott Laboratories | Methods for enhancing the effect of egcg on mitigating skeletal muscle loss |
| CN104837369A (en) * | 2012-10-04 | 2015-08-12 | 雅培制药有限公司 | Methods for enhancing the effect of EGCg on mitigating skeletal muscle loss |
| US9579347B2 (en) | 2012-10-04 | 2017-02-28 | Abbott Laboratories | Methods for enhancing the effect of EGCg on mitigating skeletal muscle loss |
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