JP2011184352A - Method for producing thiophene compound - Google Patents
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Abstract
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本発明はチオフェン化合物の製造方法に関する。チオフェン化合物は、導電性ポリマー等の機能性材料を製造する際の重要な原料として使用されている。本発明は、かかるチオフェン化合物の製造方法の改良に関する。 The present invention relates to a method for producing a thiophene compound. A thiophene compound is used as an important raw material when producing a functional material such as a conductive polymer. The present invention relates to an improvement in the method for producing such a thiophene compound.
従来、チオフェン化合物の製造方法として、下記の１）〜４）の工程を経る方法が知られている（例えば、非特許文献１参照）。１）ナトリウムエトキシドの存在下に、ジエトキシチオジグリコレートとジエチルオキザレートとを反応させて、２，５−カルボエトキシ−３，４−ジヒドロキシチオフェンを得る工程。２）炭酸カリウムの存在下に、前記の１）で得られた２，５−カルボエトキシ−３，４−ジヒドロキシチオフェンに１，２−ジブロモエタンを反応させて、２，５−カルボエトキシ−３，４−エチレンジオキシチオフェンを得る工程。３）前記の２）で得られた２，５−カルボエトキシ−３，４−エチレンジオキシチオフェンを水酸化ナトリウムで加水分解する工程。４）前記の３）で加水分解したものを脱炭酸する工程。しかし、かかる従来法には、チオフェンの製造に複雑な多くの工程を要するため、手間がかかり、製造効率が悪いという問題がある。 Conventionally, a method of undergoing the following steps 1) to 4) is known as a method for producing a thiophene compound (see, for example, Non-Patent Document 1). 1) A step of reacting diethoxythiodiglycolate with diethyl oxalate in the presence of sodium ethoxide to obtain 2,5-carboethoxy-3,4-dihydroxythiophene. 2) 1,2-dibromoethane is reacted with 2,5-carboethoxy-3,4-dihydroxythiophene obtained in 1) above in the presence of potassium carbonate to give 2,5-carboethoxy-3 , 4-Ethylenedioxythiophene. 3) A step of hydrolyzing the 2,5-carboethoxy-3,4-ethylenedioxythiophene obtained in 2) with sodium hydroxide. 4) A step of decarboxylating the product hydrolyzed in the above 3). However, such a conventional method requires many complicated steps for producing thiophene, and thus takes time and has a problem of poor production efficiency.
前記のような問題を解決するチオフェン化合物の製造方法として、α−ジオン化合物にアルコールを反応させてジアセタール化合物を得た後、かかるジアセタール化合物に硫黄を反応させてチオフェン化合物を得る方法も提案されている（例えば、非特許文献２参照）。しかし、かかる従来法には、チオフェン化合物の収率が著しく低いという問題がある。 As a method for producing a thiophene compound that solves the above problems, a method is also proposed in which an α-dione compound is reacted with an alcohol to obtain a diacetal compound, and then the diacetal compound is reacted with sulfur to obtain a thiophene compound. (For example, refer nonpatent literature 2). However, this conventional method has a problem that the yield of the thiophene compound is extremely low.
本発明が解決しようとする課題は、チオフェン化合物を簡便に且つ収率良く得ることができる方法を提供する処にある。 The problem to be solved by the present invention is to provide a method by which a thiophene compound can be obtained simply and with high yield.
しかして本発明者らは、前記の課題を解決するべく研究した結果、特定の触媒存在下で、特定のジアセタール化合物に硫黄を反応させる方法が正しく好適であることを見出した。 Therefore, as a result of studies to solve the above problems, the present inventors have found that a method of reacting sulfur with a specific diacetal compound in the presence of a specific catalyst is correctly suitable.
すなわち本発明は、遷移金属触媒の存在下で、下記の化１又は化２で示されるジアセタール化合物に硫黄を反応させて、下記の化３又は化４で示されるチオフェン化合物を得ることを特徴とするチオフェン化合物の製造方法に係る。
That is, the present invention is characterized in that sulfur is reacted with a diacetal compound represented by the following chemical formula 1 or chemical formula 2 in the presence of a transition metal catalyst to obtain a thiophene compound represented by chemical formula 3 or chemical formula 4 below. The present invention relates to a method for producing a thiophene compound.
化１〜化４において、
Ｘ，Ｙ：水素原子、炭素数１〜１２のアルキル基、炭素数１〜１２のアルコキシ基、トリフルオロメタンスルホニル基、トルエンスルホニル基、フッ素原子、塩素原子、臭素原子又はヨウ素原子
Ｒ１，Ｒ２，Ｒ３：炭素数１〜１２のアルキル基
Ａ：多価アルコールから２個の水酸基を除いた残基
In Chemical Formulas 1 to 4,
X, Y: hydrogen atom, alkyl group having 1 to 12 carbon atoms, alkoxy group having 1 to 12 carbon atoms, trifluoromethanesulfonyl group, toluenesulfonyl group, fluorine atom, chlorine atom, bromine atom or iodine atom R 1 , R 2 , R 3 : an alkyl group having 1 to 12 carbon atoms A: a residue obtained by removing two hydroxyl groups from a polyhydric alcohol
本発明に供するジアセタール化合物は、化１又は化２で示されるものであるが、なかでも化１又は化２中のＲ１〜Ｒ３が炭素数１〜３のアルキル基であり、またＸ及びＹが水素原子である場合のものが好ましい。 The diacetal compound to be used in the present invention is represented by Chemical Formula 1 or Chemical Formula 2, among which R 1 to R 3 in Chemical Formula 1 or Chemical Formula 2 are alkyl groups having 1 to 3 carbon atoms, and X and The case where Y is a hydrogen atom is preferred.
本発明に供する遷移金属触媒としては、１）ＰｄＣｌ２、ＰｄＢｒ２、Ｐｄ(ＯＡｃ)２、Ｐｄ(ａｃａｃ)２、Ｐｄ(ＯＣＯＣＦ３)２、Ｐｄ(ｄｂａ)２、Ｐｄ(ＰＰｈ３)２Ｃｌ２,Ｐｄ（ＰＰｈ３）４、Ｐｄ−ｂｌａｃｋ、Ｐｄ／Ｃ等のパラジウム触媒、２）Ｆｅ、ＦｅＦ３、Ｆｅ２Ｏ３、Ｆｅ（ａｃａｃ）３、ＦｅＣｌ３、ＦｅＢｒ３等の鉄触媒、３）ＷＣｌ６、ＷＯ３等のタングステン触媒、４）ＭｏＯ２、ＭｏＳ２、ＭｏＳ２／ＳｉＯ2等のモリブデン触媒、５）ＮｉＣｌ２、ＮｉＦ２、ＮｉＣｌ２（ｄｐｐｐ）、Ｎｉ（ａｃａｃ）２、Ｎｉ（ｃｏｄ）２等のニッケル触媒、６）ＣｏＦ２、ＣｏＣｌ２等のコバルト触媒、７）ＩｒＣｌ３、ＩｒＯ２、Ｉｒ／Ｃ等のイリジウム触媒、８）ＰｔＣｌ２、ＰｔＩ２、ＰｔＣｌ４、ＰｔＯ２、Ｐｔ／Ｃ等の白金触媒、９）ＣｕＣｌ、ＣｕＩ、ＣｕＩ２、ＣｕＣｌ２、Ｃｕ２ＳＯ４、ＣｕＯ、Ｃｕ（ａｃａｃ）２、ＣｕＴＣ等の銅触媒、１０）ＲｈＣｌ（ＰＰｈ３）３等のロジウム触媒、１１）ＲｕＣｌ２（ＰＣｙ３）２等のルテニウム触媒等が挙げられるが、なかでもパラジウム触媒が好ましい。 Examples of the transition metal catalyst used in the present invention are 1) PdCl 2 , PdBr 2 , Pd (OAc) 2 , Pd (acac) 2 , Pd (OCOCF 3 ) 2 , Pd (dba) 2 , Pd (PPh 3 ) 2 Cl 2 , Pd (PPh 3 ) 4 , Pd-black, Pd / C and other palladium catalysts, 2) Fe, FeF 3 , Fe 2 O 3 , Fe (acac) 3 , FeCl 3 , FeBr 3 and other iron catalysts, 3 ) Tungsten catalyst such as WCl 6 , WO 3 , 4) Molybdenum catalyst such as MoO 2 , MoS 2 , MoS 2 / SiO 2 , 5) NiCl 2 , NiF 2 , NiCl 2 (dppp), Ni (acac) 2 , Ni (cod) 2 and the like of a nickel catalyst, 6) CoF 2, CoCl 2, etc. cobalt catalyst, 7) IrCl 3, IrO 2 , Ir / C , etc. iridium catalyst, 8) PtCl 2 PtI 2, PtCl 4, PtO 2 , Pt / C or the like of platinum catalysts, 9) CuCl, CuI, CuI 2, CuCl 2, Cu 2 SO 4, CuO, Cu (acac) 2, CuTC like of a copper catalyst, 10) Examples include rhodium catalysts such as RhCl (PPh 3 ) 3 and 11) ruthenium catalysts such as RuCl 2 (PCy 3 ) 2 , among which palladium catalysts are preferable.
遷移金属触媒存在下での化１又は化２で示されるジアセタール化合物と硫黄との反応は、溶媒系にて行なわれる。用いる溶媒としては、１）ベンゼン、トルエン、キシレン等の芳香族炭化水素、２）ヘキサン、ヘプタン、オクタン、ノナン、デカン、ドデカン等の脂肪族炭化水素、３）クロロベンゼン、ジクロロベンゼン、ブロモベンゼン、四塩化炭素、クロロホルム、ジクロロエタン等のハロゲン化炭化水素、４）メタノール、エタノール、ｎ−プロピルアルコール、ｉ−プロピルアルコール、ブタノール、ペンタノール、ヘキサノール、ヘプタノール、オクタノール、デカノール等の脂肪族アルコール、５）ベンジルアルコール等の芳香族アルコール、６）エチレングリコール、プロピレングリコール、グリセリン等の多官能アルコール、７）フェノール、カテコール等のフェノール類、８）Ｎ，Ｎ−ジメチルホルムアミド、Ｎ，Ｎ−ジメチルアセトアミド等のアミド系溶媒、９）デシルアミン、ドデシルアミン、エチレンジアミン、アニリン等のアミン系溶媒、１０）１，４−ジオキサン等のエーテル系溶媒、１１）ジメチルスルホキシド、１２）水等が挙げられ、これらは２種以上を併用することもできる。 The reaction of the diacetal compound represented by Chemical Formula 1 or Chemical Formula 2 with sulfur in the presence of a transition metal catalyst is carried out in a solvent system. Solvents used include 1) aromatic hydrocarbons such as benzene, toluene and xylene, 2) aliphatic hydrocarbons such as hexane, heptane, octane, nonane, decane and dodecane, 3) chlorobenzene, dichlorobenzene, bromobenzene, and four. Halogenated hydrocarbons such as carbon chloride, chloroform, dichloroethane, etc. 4) Aliphatic alcohols such as methanol, ethanol, n-propyl alcohol, i-propyl alcohol, butanol, pentanol, hexanol, heptanol, octanol, decanol, etc. 5) Benzyl Aromatic alcohols such as alcohol, 6) Polyfunctional alcohols such as ethylene glycol, propylene glycol and glycerin, 7) Phenols such as phenol and catechol, 8) N, N-dimethylformamide, N, N-dimethylacetate Amide solvents such as amide, 9) amine solvents such as decylamine, dodecylamine, ethylenediamine, aniline, 10) ether solvents such as 1,4-dioxane, 11) dimethyl sulfoxide, 12) water, etc. Can also use 2 or more types together.
遷移金属触媒存在下での化１又は化２で示されるジアセタール化合物と硫黄との反応において、遷移金属触媒の使用量は、ジアセタール化合物１モル当たり、０．００１モル以上とするのが好ましく、０．０１モル以上とするのがより好ましい。また硫黄の使用量は、ジアセタール化合物１モル当たり、０．１２５〜３０モルとするのが好ましく、０．１２５〜１０モルとするのがより好ましい。更に反応を行なうときの溶媒の使用量は、ジアセタール化合物１質量部当たり、１〜１００質量部とするのが好ましく、３〜３０質量部とするのが好ましい。そして反応温度は、２０〜２３０℃とするのが好ましく、５０〜２００℃とするのがより好ましい。いずれも、チオフェン化合物の収率を、経済的且つ効率的に、高めるためである。 In the reaction between the diacetal compound represented by Chemical Formula 1 or Chemical Formula 2 and sulfur in the presence of a transition metal catalyst, the amount of the transition metal catalyst used is preferably 0.001 mole or more per mole of the diacetal compound. More preferably, the amount is 0.01 mole or more. Moreover, it is preferable to set it as 0.125-30 mol with respect to 1 mol of diacetal compounds, and, as for the usage-amount of sulfur, it is more preferable to set it as 0.125-10 mol. Furthermore, the amount of the solvent used for the reaction is preferably 1 to 100 parts by mass, more preferably 3 to 30 parts by mass, per 1 part by mass of the diacetal compound. The reaction temperature is preferably 20 to 230 ° C, more preferably 50 to 200 ° C. In any case, the yield of the thiophene compound is increased economically and efficiently.
以上説明したような反応により、化３又は化４で示されるチオフェン化合物を得ることができる。具体的には、反応系から、抽出、水洗、乾燥、濃縮等のそれ自体は公知の手段を経て、目的とするチオフェン化合物を分離することができる。分離したチオフェン化合物は、蒸留等のこれもそれ自体は公知の精製手段によりその純度を高めることもできる。 Through the reaction described above, the thiophene compound represented by Chemical Formula 3 or Chemical Formula 4 can be obtained. Specifically, the target thiophene compound can be separated from the reaction system by a known means such as extraction, washing with water, drying and concentration. The purity of the separated thiophene compound can be increased by a purification means known per se such as distillation.
本発明により得られるチオフェン化合物は、機能性材料を製造する際の重要な原料として用いられる。特に３，４−エチレンジオキシチオフェンは、ノートパソコンや携帯電話等のコンデンサに使用される導電性ポリマーの原料として有用である。 The thiophene compound obtained by the present invention is used as an important raw material when producing a functional material. In particular, 3,4-ethylenedioxythiophene is useful as a raw material for conductive polymers used in capacitors such as notebook computers and mobile phones.
以上説明した本発明には、機能性材料等を製造する際の原料として有用なチオフェン化合物を簡便に且つ収率良く得ることができるという効果がある。 The present invention described above has an effect that a thiophene compound useful as a raw material for producing a functional material or the like can be obtained simply and with a high yield.
以下、本発明の構成及び効果をより具体的にするため、実施例を挙げるが、本発明がこれらの実施例に限定されるというものではない。尚、以下の実施例において、部は質量部を、また％は質量％を意味する。 EXAMPLES Hereinafter, examples will be given in order to make the configuration and effects of the present invention more specific, but the present invention is not limited to these examples. In the following examples, “part” means “part by mass” and “%” means “% by mass”.
・実施例１
アルゴン気流下で５００ｍＬ二口ナス型フラスコに、化２で示されるジアセタール化合物として２，３−ジメチル−２，３−ジメトキシ−ジオキサン１７．６ｇ（１００ｍｍｏｌ）、硫黄１２８．０ｇ（５００ｍｍｏｌ）及び触媒としてＰｄＣｌ２８．７７ｇ（５０ｍｍｏｌ）を、溶媒としてジクロロベンゼン１００ｍＬを用いて加え、加熱還流下、３時間攪拌した。反応終了後、空冷し、濾過して固形分を取り除き、酢酸エチルで抽出した。抽出した有機層を、飽和炭酸水素ナトリウム水溶液と飽和塩化ナトリウム水溶液とで洗浄し、硫酸ナトリウムを用いて乾燥した後、綿栓ろ過を行い、ろ液をロータリーエバポレーターで濃縮し、粗生成物を得た。得られた粗生成物をカラムクロマトグラフィー（ヘキサン／酢酸エチル＝１０／１）で精製し、化４で示されるチオフェン化合物として３，４−エチレンジオキシチオフェン３．６９ｇ（２６ｍｍｏｌ、収率２６％）を得た。
Example 1
In a 500 mL two-necked eggplant-type flask under an argon stream, 2,3-dimethyl-2,3-dimethoxy-dioxane 17.6 g (100 mmol), sulfur 128.0 g (500 mmol) and a catalyst as a diacetal compound represented by Chemical formula 2 8.77 g (50 mmol) of PdCl 2 was added using 100 mL of dichlorobenzene as a solvent, and the mixture was stirred for 3 hours with heating under reflux. After completion of the reaction, the reaction mixture was air-cooled, filtered to remove solids, and extracted with ethyl acetate. The extracted organic layer is washed with a saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium chloride solution, dried using sodium sulfate, filtered with a cotton plug, and the filtrate is concentrated with a rotary evaporator to obtain a crude product. It was. The obtained crude product was purified by column chromatography (hexane / ethyl acetate = 10/1), and 3.69 g (26 mmol, 26% yield) of 3,4-ethylenedioxythiophene as the thiophene compound represented by Chemical formula 4 )
・比較例１
アルゴン気流下で、５００ｍＬ二口ナス型フラスコに、化２で示されるジアセタール化合物として２，３−ジメチル−２，３−ジメトキシ−ジオキサン１７．６ｇ（１００ｍｍｏｌ）及び硫黄１２８．０ｇ（５００ｍｍｏｌ）を、溶媒としてジクロロベンゼン１００ｍＬを用いて加え、加熱還流下、３時間攪拌した。反応終了後、空冷し、濾過して固形分を取り除き、酢酸エチルで抽出した。抽出した有機層を飽和炭酸水素ナトリウム水溶液と飽和塩化ナトリウム水溶液とで洗浄し、硫酸ナトリウムを用いて乾燥した後、綿栓ろ過を行い、ろ液をロータリーエバポレーターで濃縮し、粗生成物を得た。得られた粗生成物をカラムクロマトグラフィー（ヘキサン／酢酸エチル＝１０／１）で精製したが、目的とする化４で示されるチオフェン化合物としての３，４−エチレンジオキシチオフェンを得ることができなかった。
Comparative example 1
Under a stream of argon, 17.6 g (100 mmol) of 2,3-dimethyl-2,3-dimethoxy-dioxane and 128.0 g (500 mmol) of sulfur as a diacetal compound represented by Chemical Formula 2 were added to a 500 mL two-necked eggplant type flask. Dichlorobenzene (100 mL) was added as a solvent, and the mixture was stirred for 3 hours with heating under reflux. After completion of the reaction, the reaction mixture was air-cooled, filtered to remove solids, and extracted with ethyl acetate. The extracted organic layer was washed with a saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium chloride solution, dried using sodium sulfate, filtered with a cotton plug, and the filtrate was concentrated with a rotary evaporator to obtain a crude product. . Although the obtained crude product was purified by column chromatography (hexane / ethyl acetate = 10/1), 3,4-ethylenedioxythiophene as the thiophene compound represented by the chemical formula 4 can be obtained. There wasn't.
・比較例２
アルゴン気流下で、５００ｍＬ二口ナス型フラスコに、化２で示されるジアセタール化合物として２，３−ジメチル−２，３−ジメトキシ−ジオキサン１７．６ｇ（１００ｍｍｏｌ）及び硫黄１２８．０ｇ（５００ｍｍｏｌ）を、溶媒としてジクロロベンゼン１００ｍＬを用いて加え、加熱還流下、３時間攪拌した。反応終了後、空冷し、濾過して固形分を取り除き、酢酸エチルで抽出した。抽出した有機層を飽和炭酸水素ナトリウム水溶液と飽和塩化ナトリウム水溶液とで洗浄し、硫酸ナトリウムを用いて乾燥した後、綿栓ろ過を行い、ろ液をロータリーエバポレーターで濃縮し、粗生成物を得た。得られた粗生成物をカラムクロマトグラフィー（ヘキサン／酢酸エチル＝１０／１）で精製したが、目的とする化４で示されるチオフェン化合物としての３，４−エチレンジオキシチオフェンを得ることができなかった。
Comparative example 2
Under a stream of argon, 17.6 g (100 mmol) of 2,3-dimethyl-2,3-dimethoxy-dioxane and 128.0 g (500 mmol) of sulfur as a diacetal compound represented by Chemical Formula 2 were added to a 500 mL two-necked eggplant type flask. Dichlorobenzene (100 mL) was added as a solvent, and the mixture was stirred for 3 hours with heating under reflux. After completion of the reaction, the reaction mixture was air-cooled, filtered to remove solids, and extracted with ethyl acetate. The extracted organic layer was washed with a saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium chloride solution, dried using sodium sulfate, filtered with a cotton plug, and the filtrate was concentrated with a rotary evaporator to obtain a crude product. . Although the obtained crude product was purified by column chromatography (hexane / ethyl acetate = 10/1), 3,4-ethylenedioxythiophene as the thiophene compound represented by the chemical formula 4 can be obtained. There wasn't.
・比較例３
アルゴン気流下で、５０ｍＬ二口ナス型フラスコに、Ｎ−クロロスクシンイミド（ＮＣＳ）２．４９ｇ（１８．８ｍｍｏｌ）を入れ、十分に乾燥した後、塩化硫黄１．６９ｇ（１２．５ｍｍｏｌ）を加え、更に溶媒として１，２−ジクロロエタン１０ｍＬを加えて、加熱還流下に２４時間攪拌した。反応系の温度を室温に戻し、２，３−ジメチル−２，３−ジメトキシ−ジオキサン１．７２ｇ（１０．０ｍｍｏｌ）を、溶媒としてヘキサン５．０ｍＬを用いて加え、更に酢酸ナトリウム１．９７ｇ（２４．０ｍｍｏｌ）を加えて、加熱還流下に２０時間攪拌した。撹拌を止め、酢酸エチルを加えて抽出し、抽出分のセライトろ過を行い、ろ液を熱をかけずにロータリーエバポレーターで濃縮し、粗生成物を得た。得られた粗生成物を１５．２４ｋＰａ、１００℃で減圧蒸留することにより一度精製し、更に薄層クロマトグラフィー（ヘキサン／酢酸エチル＝１０／１）で精製して、化４で示されるチオフェン化合物として３，４−エチレンジオキシチオフェン０．０２８ｇ（０．２ｍｍｏｌ、収率２％）を得た。
Comparative example 3
Under a stream of argon, N-chlorosuccinimide (NCS) 2.49 g (18.8 mmol) was put into a 50 mL two-necked eggplant-shaped flask, and after sufficiently drying, 1.69 g (12.5 mmol) of sulfur chloride was added, Further, 10 mL of 1,2-dichloroethane was added as a solvent, and the mixture was stirred for 24 hours while heating under reflux. The temperature of the reaction system was returned to room temperature, 1.72 g (10.0 mmol) of 2,3-dimethyl-2,3-dimethoxy-dioxane was added using 5.0 mL of hexane as a solvent, and 1.97 g of sodium acetate ( 24.0 mmol) was added, and the mixture was stirred for 20 hours with heating under reflux. Stirring was stopped, ethyl acetate was added for extraction, celite filtration was performed on the extract, and the filtrate was concentrated with a rotary evaporator without applying heat to obtain a crude product. The obtained crude product was purified once by distillation under reduced pressure at 15.24 kPa and 100 ° C., and further purified by thin layer chromatography (hexane / ethyl acetate = 10/1) to obtain a thiophene compound represented by Chemical formula 4 As a result, 0.028 g (0.2 mmol, yield 2%) of 3,4-ethylenedioxythiophene was obtained.
以上の各例の内容及び原料として用いたジアセタール化合物から求めた収率を表１にまとめて示した。 The contents of the above examples and the yields obtained from the diacetal compounds used as raw materials are summarized in Table 1.
表１の結果からも明らかなように、本発明によると、機能性材料等を製造する際の原料として有用なチオフェン化合物を簡便に且つ収率良く得ることができる。 As is clear from the results in Table 1, according to the present invention, a thiophene compound useful as a raw material for producing a functional material or the like can be obtained simply and with a high yield.
Claims (3)
Ｘ，Ｙ：水素原子、炭素数１〜１２のアルキル基、炭素数１〜１２のアルコキシ基、トリフルオロメタンスルホニル基、トルエンスルホニル基、フッ素原子、塩素原子、臭素原子又はヨウ素原子
Ｒ１，Ｒ２，Ｒ３：炭素数１〜１２のアルキル基
Ａ：多価アルコールから２個の水酸基を除いた残基） In the presence of a transition metal catalyst, sulfur is reacted with a diacetal compound represented by chemical formula 1 or chemical formula 2 below to obtain a thiophene compound represented by chemical formula 3 or chemical formula 4 below. Method.
X, Y: hydrogen atom, alkyl group having 1 to 12 carbon atoms, alkoxy group having 1 to 12 carbon atoms, trifluoromethanesulfonyl group, toluenesulfonyl group, fluorine atom, chlorine atom, bromine atom or iodine atom R 1 , R 2 , R 3 : an alkyl group having 1 to 12 carbon atoms A: a residue obtained by removing two hydroxyl groups from a polyhydric alcohol)
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| CN113173908A (en) * | 2021-04-27 | 2021-07-27 | 江西师范大学 | Preparation method of thiophene compound |
| CN113173908B (en) * | 2021-04-27 | 2022-05-27 | 江西师范大学 | Preparation method of thiophene compound |
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