JP2011147611A - Method and device for analyzing anterior ocular tomographic image - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To enable an inspector to easily determine an opening degree of a corner using information on a V-shape line based on a setting-completing signal. <P>SOLUTION: The method for analyzing an anterior ocular tomographic image for analyzing the anterior ocular tomographic image including the corner area of the eye to be inspected includes: a step for displaying the anterior ocular image on a monitor; a reference-line-setting step for setting a reference line contacting with inner faces of a anterior ocular tomographic image cornea and sclera displayed on the monitor and displaying the same on the monitor; a referring-point setting step for setting a reference point where the vertical line to the reference line and an iris front face cross each other; an auxiliary-line displaying step for setting an auxiliary line which passes through the reference point, extends in a direction toward a corner bottom and crosses the reference line, displaying the V-shape line comprising the reference line and the auxiliary line on the monitor, and turning the auxiliary line around the reference point according to an operation signal form an operation input means; and a step for calculating the opening degree of the anterior ocular corner of the eye to be inspected by using the information on the V-shape line based on the setting completing signal. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a method for analyzing an anterior segment cross-sectional image.

  As a method of obtaining an anterior segment cross-sectional image including the corner area of the subject's eye and grasping the width of the corner, the examiner uses a graphic display while looking at the anterior segment sectional image displayed on the monitor. A technique for calculating the degree of opening of a corner by performing each input operation is known.

Yuki Takahashi, “Corner”, Ophthalmological Practice, Eye Biometry, Bunkodo, January 19, 2009, p.132-p139

  However, in the case of the conventional method, it is not easy to determine the angle of the anterior chamber angle formed by the cornea back surface and the iris front surface. In particular, depending on the device for taking a cross-sectional image of the anterior segment (for example, when the wavelength used by the optical coherence tomography is short), it may be difficult to see the image near the corner base. Was not easy.

  In view of the above problems, it is an object of the present invention to provide an anterior ocular segment image analysis method and an anterior ocular segment image analysis apparatus in which an examiner can easily determine the degree of opening of a corner.

  In order to solve the above problems, the present invention is characterized by having the following configuration.

(1) In the anterior ocular segment image analysis method for analyzing the anterior ocular segment image including the corner area of the eye to be examined,
Displaying an anterior segment cross-sectional image on a monitor;
A reference line setting step of setting a reference line in contact with the inner surface of the anterior segment cross-sectional image cornea and sclera displayed on the monitor and displaying on the monitor;
A reference point setting step for setting a reference point at which the perpendicular to the reference line and the iris front intersect,
An auxiliary line passing through the reference point and extending toward the even angle bottom direction is set as an auxiliary line intersecting with the reference line, and a V-shaped line composed of the reference line and the auxiliary line is displayed on the monitor and operated. An auxiliary line display step of turning the auxiliary line around the reference point according to an operation signal from the input means;
Calculating the degree of opening of the anterior chamber corner of the eye to be examined using the V-shaped information based on a setting completion signal;
It is characterized by having.
(2) The anterior segment cross-sectional image analysis method according to (1) is characterized by performing division in order in the order of a reference line setting step, a reference point setting step, and an auxiliary line display step.
(3) The anterior segment cross-sectional image analysis method of (2)
The reference line setting step includes a step of setting a reference point on the inner surface of the cornea and sclera on the monitor, a step of setting a corneal reference point that is a predetermined distance away from the reference point along the cornea back surface, and the reference point And a step of setting a line connecting the corneal reference point as a reference line.
(4) In the anterior segment cross-sectional image analysis method of (3),
In the auxiliary line display step, the auxiliary line is turned in response to a drag operation on the auxiliary line.
(5) An anterior ocular segment cross-sectional image acquisition unit for obtaining an anterior ocular segment tomographic image, a storage unit for storing the anterior ocular segment cross-sectional image acquired by the anterior ocular segment cross-sectional image acquisition unit, and an anterior ocular segment cross-sectional image are displayed. A monitor, an operation input unit for performing each setting using the anterior segment cross-sectional image displayed on the display unit, an anterior segment cross section based on the stored anterior segment cross-sectional image and the setting result by the input unit In an anterior segment cross-sectional image analysis device having an arithmetic processing unit for performing analysis processing for analyzing an image,
The analysis process is
Displaying an anterior segment cross-sectional image on a monitor;
A reference line setting step of setting a reference line in contact with the inner surface of the anterior segment cross-sectional image cornea and sclera displayed on the monitor and displaying on the monitor;
A reference point setting step for setting a reference point at which the perpendicular to the reference line and the iris front intersect,
An auxiliary line passing through the reference point and extending toward the even angle bottom direction is set as an auxiliary line intersecting with the reference line, and a V-shaped line composed of the reference line and the auxiliary line is displayed on the monitor and operated. An auxiliary line display step of turning the auxiliary line around the reference point according to an operation signal from the input means;
Calculating the degree of opening of the anterior chamber corner of the eye to be examined using the V-shaped information based on a setting completion signal;
It is characterized by having.

  According to the present invention, the examiner can easily determine the degree of opening of the corner.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a block diagram illustrating the configuration of the anterior segment cross-sectional image analysis apparatus according to the present embodiment.

  An anterior segment cross-sectional image analysis apparatus 1 for analyzing the anterior segment cross-sectional image acquired by the anterior segment cross-sectional image apparatus 10 includes a CPU (arithmetic processing unit) 70, a mouse (operation input unit) 76, and a memory. (Storage unit) 72 and a monitor 75, and each unit is electrically connected to the CPU 70 via a bus or the like.

  The CPU 70 analyzes the anterior ocular segment image based on the anterior ocular segment image analysis program stored in the memory 72. By executing this program on a computer, the anterior segment cross-sectional image analysis apparatus 1 can be used. The CPU 70 performs an analysis process for analyzing the anterior segment cross-sectional image stored in the memory 72 and the setting result by the mouse 76. Further, the CPU 70 controls the display screen of the monitor 75 according to the anterior segment cross-sectional image analysis program.

  The mouse 76 in this embodiment includes a sensor for detecting a movement signal when the body of the mouse 76 is two-dimensionally moved by the examiner's hand, and a left and right for detecting that the mouse 76 is pressed by the examiner's hand. Two mouse buttons and a wheel mechanism that is rotatable in the front-rear direction are provided between the two left and right mouse buttons. The mouse 76 is used as an operation input unit for performing each setting using the anterior segment cross-sectional image. As the CPU 70, mouse 76, memory 72, and monitor 75, an arithmetic processing unit, an input unit, a storage unit, and a display unit of a commercially available PC (personal computer) are used, and an analysis program is installed on the commercially available PC. Also good.

  Note that an anterior ocular segment image capturing device 10 for capturing an anterior ocular segment cross-sectional image of an eye to be examined is connected to the anterior ocular segment image analyzing apparatus 1. In the present embodiment, an optical coherence tomography (OCT) is used as the imaging apparatus 10.

<Analysis of anterior segment cross-sectional image including corner area>
Hereinafter, an analysis method when an anterior ocular segment tomographic image (anterior ocular segment cross-sectional image) including a corner area of the eye to be examined is obtained by the above apparatus will be described. FIG. 2 is a diagram showing a specific example in the case of quantitative analysis of the corner area of the eye to be examined. First, the examiner operates the mouse 76 to start an analysis program, and obtains image data of an anterior segment tomographic image stored in the memory 72. Then, the anterior segment tomographic image At is displayed on the monitor 75.

  The analysis program sets a reference line (for example, a reference straight line SL) in which the anterior segment cross-sectional image is displayed on the monitor 75 and the anterior segment cross-sectional image displayed on the monitor 75 is in contact with the cornea and the inner surface of the sclera. A reference line setting step to be displayed on the monitor 75, a reference point setting step for setting a reference point (eg, reference point R2) where a perpendicular to the reference line and the iris front intersect, and an auxiliary line passing through the reference point (eg, an auxiliary line) An auxiliary line that extends toward the base of the even angle and intersects with the reference line, displays a V-shaped line composed of the reference line and the auxiliary line on the monitor 75, and operation input means (for example, mouse 76) ), The auxiliary line display step for turning the auxiliary line around the reference point according to the operation signal from the control signal, and the opening degree of the anterior chamber angle of the eye to be examined using the V-shaped information based on the setting completion signal. A calculating step; A.

  A specific procedure will be described below. In the following description, a case will be described in which the reference line setting step, the reference point setting step, and the auxiliary line display step are sequentially divided.

  The reference line setting step includes a step of setting a reference point S on the inner surfaces of the cornea and sclera on the monitor 75, a step of setting a corneal reference point R1 that is a predetermined distance away from the reference point S along the cornea back surface, Setting a line connecting the point S and the cornea reference point R1 as a reference line (reference line SL).

  First, the examiner operates the mouse 76 to set the reference point S for quantitative analysis in the image At displayed on the monitor 75 (see FIG. 2A). The examiner moves the cursor 100 on the monitor 75, aligns the dot display at the tip of the cursor 100 with a reference region (for example, scleral cape) on the image, and performs a click operation.

  When the setting completion signal is input in this way, the CPU 70 displays the reference point S at the designated position and also displays the circle C1 and the circle C2 centered on the reference point S (FIG. 2B). reference). The circle C1 corresponds to a circle having a radius of 500 μm on the image, and the circle C2 corresponds to a circle having a radius of 750 μm on the image. When the tip of the cursor 100 is placed on the circumferences of the circles C1 and C2, a point is displayed at a designated position. When the reference point S is a scleral cape, the positions 500 μm and 750 μm away from the scleral cape are said to be suitable for evaluating the degree of opening of the corners.

  The examiner operates the mouse 76 to set a reference point R1 that is a predetermined distance (eg, 500 μm, 750 μm) away from the reference point S along the back surface of the cornea. Here, the examiner aligns the tip of the cursor 100 with the intersection of the circle C1 or the circle C2 and the back of the cornea and performs a click operation. In this case, the examiner can arbitrarily select which one of the circle C1 and the circle C2 is used.

  Here, when the setting completion signal is input, the CPU 70 displays the reference point R1 at the designated position, the reference line SL connecting the reference point S and the reference point R1, and the reference point S with respect to the reference line SL. The vertical line P1 from the vertical line and the vertical line P2 from the reference point R1 are displayed (see FIG. 2C). When the tip of the cursor 100 is placed on the vertical line P1 or the vertical line P2, a point is displayed at a designated position.

  Next, the process proceeds to a reference point setting step. The examiner operates the mouse 76 to set a reference point (iris reference point) R2 where the perpendicular line P1 (or perpendicular line P2) and the iris front surface intersect (see FIG. 2C). Here, the examiner aligns the tip of the cursor 100 with the intersection of the perpendicular line P1 or perpendicular line P2 and the front of the iris, and performs a click operation. In this case, which of the perpendicular line P1 and the perpendicular line P2 is used can be arbitrarily selected by the examiner.

  Next, the process proceeds to an auxiliary line display step. When the setting completion signal is input, the CPU 70 displays the reference point R2 at the designated position (see FIG. 2D). Further, the CPU 70 intersects a reference straight line (displayed as a line segment in FIG. 2D) SL connecting the reference point S and the reference point R1, and an arbitrary point on the reference straight line SL through the reference point R2. The auxiliary line AL is displayed on the monitor 75, and these are displayed so as to draw a V-shape. When the auxiliary line AL is designated by the cursor 100 and a drag operation is performed, the auxiliary line AL is displayed by turning around the reference point R2 (see the arrow in FIG. 2D). Further, the angle of the auxiliary line AL with respect to the reference straight line SL is calculated as needed, and the angle display is changed according to the turning of the auxiliary line AL.

  The examiner operates the mouse 76 to associate the cross-sectional image with the V-shaped line (see FIG. 2D). Here, the examiner drags the auxiliary line AL to adjust the angle of the auxiliary line AL with respect to the reference straight line SL.

  In this case, the examiner obtains a desired positional relationship while confirming the positional relationship between the portion where the corneal back surface and the iris front surface clearly appear on the image, and the reference straight line SL and the V-shaped straight line by the auxiliary line AL. Adjust the angle of the auxiliary line AL. Thereafter, the examiner moves the cursor 100 to the FINIG display below the image At and performs a click operation.

Here, when the setting completion signal is input, the CPU 70 calculates various parameters related to the opening degree of the corner, and displays the calculation result on the monitor 75 (see FIG. 2F). In addition, AOD (angle opening distance) 500 is the distance (unit: μm) between two points: a point 500 μm away from the sclera along the back of the cornea and a point where a straight line drawn perpendicularly intersects the front of the iris. Represents. ACA (anterior chamber angle) represents the angle (unit: degree) of the angle formed by the points at both ends of the AOD 500 and the angle recess. TISA (trabecular iris space area) 500 represents the area (unit: mm ² ) of AOD 500, a straight line drawn parallel to AOD from the sclera cape, the cornea back surface, and the portion surrounded by the iris front surface (hatched portion).

  With the above configuration, the examiner can manually adjust the angle of the anterior chamber corner by associating the V-shaped display by the reference line SL and the auxiliary line AL with the cornea back surface and the iris front surface on the image. Settings can be made smoothly. In particular, when the image near the corner bottom is difficult to see, the V-shaped display using the reference straight line SL and the auxiliary line AL makes it easy for the examiner to associate the difficult-to-see part on the back of the cornea with the front of the iris and the part that appears clearly. Thus, the manual setting of the anterior chamber corner angle can be performed smoothly.

  As for the V-shaped straight line by the reference straight line SL and the auxiliary line AL, the V-shaped straight line is formed on the screen in a state where at least one of the reference straight line SL and the auxiliary line AL is extended in the peripheral direction. Also good.

  In the above description, the auxiliary line AL is moved by a drag operation. However, the present invention is not limited to this. For example, when the tip of the cursor 100 is placed on the reference straight line SL, a point is displayed at the designated tip position, and in conjunction with the movement of the cursor 100 on the reference straight line SL, the point and the reference point R2 are displayed. The auxiliary line AL to be connected may be displayed by turning around the reference point R2. In this case, the reference straight line SL is preferably extended in the peripheral direction.

  Further, the CPU 70 may display the reference straight line SL and the auxiliary line AL so that the colors thereof are different, or display the reference straight line SL and the auxiliary line AL so that the line types (eg, solid line and dotted line) are different. May be.

  In the above description, the setting operation of the examiner is facilitated by dividing a plurality of setting steps, which are preconditions for performing the corner analysis, so that they can be set in order.

  Further, the present invention provides a trapezoid (hatched portion) including a reference straight line SL, a perpendicular line P1, a perpendicular line P2, and an intersection R2 between the perpendicular line P1 and the iris front surface, and a line segment L3 composed of the intersection point R3 between the perpendicular line P2 and the iris front surface. The present invention can be applied even in the case where the points are set by moving the respective vertices of the trapezoid by a drag operation by displaying them on the monitor 75 in advance (see FIG. 3). In this case, in the same manner as described above, a V-shaped straight line composed of an extension line of the reference straight line SL and an auxiliary line AL by an extension line of the line segment L is displayed, and the auxiliary to the reference straight line SL according to the movement of each vertex. The angle of the line AL is adjusted.

  The setting of the reference line in contact with the inner surface of the anterior segment cross-sectional image cornea and sclera is not limited to a straight line, and a curve along the inner surface of the anterior segment cross-sectional image cornea and sclera may be set. Good. In this case, a V-shaped line composed of a reference curve and an auxiliary line is displayed on the monitor.

  The reference line setting step is set by an operator's manual operation. However, the reference line may be set by detecting the inner surface of the cornea and sclera on the image by image processing. Good. Alternatively, only the reference point may be set manually. Similarly, in the reference point setting step, the iris front point on the image may be detected by image processing to set the iris reference point.

  In the above configuration, the anterior segment cross-sectional image acquired by the optical coherence tomography (OCT) is analyzed. However, a Scheimpflug camera may be used. Further, the present invention is not limited to the optical method, and the present invention can be applied to the case of analyzing an anterior segment cross-sectional image acquired by an ultrasonic diagnostic apparatus.

It is a block diagram explaining the structure of the anterior segment cross-sectional image analysis apparatus which concerns on this embodiment. It is a figure which shows the specific example in the case of carrying out the quantitative analysis of the corner area | region of the eye to be examined. It is a figure shown about the example of a change of this embodiment.

10 anterior segment cross-sectional imaging device 70 CPU
72 Memory (storage unit)
75 Monitor 76 Mouse SL Standard straight line R2 Reference point AL Auxiliary line

Claims (5)

In the anterior ocular segment image analysis method for analyzing the anterior ocular segment image including the corner area of the eye to be examined,
Displaying an anterior segment cross-sectional image on a monitor;
A reference line setting step of setting a reference line in contact with the inner surface of the anterior segment cross-sectional image cornea and sclera displayed on the monitor and displaying on the monitor;
A reference point setting step for setting a reference point at which the perpendicular to the reference line and the iris front intersect,
An auxiliary line passing through the reference point and extending toward the even angle bottom direction is set as an auxiliary line intersecting with the reference line, and a V-shaped line composed of the reference line and the auxiliary line is displayed on the monitor and operated. An auxiliary line display step of turning the auxiliary line around the reference point according to an operation signal from the input means;
Calculating the degree of opening of the anterior chamber corner of the eye to be examined using the V-shaped information based on a setting completion signal;
An anterior segment cross-sectional image analysis method characterized by comprising:   The anterior segment cross-sectional image analysis method according to claim 1, wherein the anterior segment cross-sectional image analysis method is performed by sequentially dividing the reference line setting step, the reference point setting step, and the auxiliary line display step. The anterior segment cross-sectional image analysis method of claim 2 comprises:
The reference line setting step includes a step of setting a reference point on the inner surface of the cornea and sclera on the monitor, a step of setting a corneal reference point that is a predetermined distance away from the reference point along the cornea back surface, and the reference point An anterior ocular segment image analysis method comprising: setting a line connecting the corneal reference points as a reference line. In the anterior segment cross-sectional image analysis method according to claim 3,
In the auxiliary line display step, the auxiliary line is rotated in response to a drag operation on the auxiliary line. An anterior ocular segment cross-sectional image obtaining means for obtaining an anterior ocular segment tomographic image, a storage unit for storing the anterior ocular segment cross-sectional image obtained by the anterior ocular segment cross-sectional image obtaining unit, a monitor for displaying the anterior ocular segment cross-sectional image, An operation input unit for performing each setting using the anterior segment cross-sectional image displayed on the display unit, and the anterior segment cross-sectional image is analyzed based on the stored anterior segment cross-sectional image and the setting result by the input unit In an anterior segment cross-sectional image analysis apparatus having an arithmetic processing unit for performing analysis processing
The analysis process is
Displaying an anterior segment cross-sectional image on a monitor;
A reference line setting step of setting a reference line in contact with the inner surface of the anterior segment cross-sectional image cornea and sclera displayed on the monitor and displaying on the monitor;
A reference point setting step for setting a reference point at which the perpendicular to the reference line and the iris front intersect,
An auxiliary line passing through the reference point and extending toward the even angle bottom direction is set as an auxiliary line intersecting with the reference line, and a V-shaped line composed of the reference line and the auxiliary line is displayed on the monitor and operated. An auxiliary line display step of turning the auxiliary line around the reference point according to an operation signal from the input means;
Calculating the degree of opening of the anterior chamber corner of the eye to be examined using the V-shaped information based on a setting completion signal;
An anterior ocular segment image analysis device characterized by comprising:

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