JP2011098889A - Eosinophil activation inhibitor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a preparation for mitigating allergic symptoms by inhibiting the activation of an eosinophil which allows allergy to get worse. <P>SOLUTION: An eosinophil activation inhibitor having bee pollen as an active ingredient is very effective to solve the problem, and the eosinophil activation inhibitor can be used for allergic diseases including pollinosis. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an eosinophil activation inhibitor containing a pollen load mainly composed of pollen.

In recent years, there has been a rapid increase in the number of patients complaining of so-called hay fever symptoms such as allergic conjunctivitis and allergic rhinitis (nasal discharge, nasal congestion, sneezing) due to pollen allergies such as cedar and camellia. Pollen allergy is caused by exogenous factors, ie, pollen invasion, which releases chemical transmitters such as histamine and leukotrienes and various enzymes from mast cells and basophils, and manifests symptoms particularly in the nose and eyes.
Treatment measures for hay fever include prevention by physically preventing contact with cedar pollen, etc. by wearing glasses and a mask, prophylactic treatment with antiallergic agents, symptomatic treatment with antihistamines and steroids, desensitization Therapy is performed.

However, in order to avoid pollen such as cedar and camellia, a method of wearing a hay fever mask or glasses when going out involves some kind of pain and inconvenience. Furthermore, pollen scattering and floating invades not only outdoors but also indoors. This is because pollen such as cedar and camellia is brought indoors due to ventilation and attachment to hair, clothes or laundry. Therefore, there is a high possibility of contact with pollen indoors and outdoors when pollen such as cedar and camellia is scattered. To prevent physical contact with pollen, strictly speaking, not only when going out, Although it is necessary to wear a mask and glasses all day regardless of whether inside or outside, in daily life, contact with pollen such as cedar and camellia cannot be completely prevented.
The mechanism of action of allergy development has been studied for many years, and it has been found that eosinophils, a type of white blood cell, are involved in allergic reactions.
These eosinophils are present in blood and have granules containing a strongly basic cytotoxic protein in their cells. And when this eosinophil causes allergic reaction or inflammatory reaction, it migrates and infiltrates from the blood to the site, then releases the granule by stimulation, and it is considered that the allergic reaction or the like progresses or worsens. Activation of these eosinophils has been shown to exacerbate allergies.

  An object of the present invention is to obtain a preparation that alleviates allergic symptoms by suppressing activation of eosinophils that exacerbate allergies.

As a result of intensive studies, the present inventors have found that a pollen load has an action of suppressing the activation of eosinophils and can obtain a preparation that alleviates allergic symptoms.
The pollen load is pollen collected by bees and contains nectar, saliva, etc. in addition to pollen. No component effective for inhibiting eosinophil activation has been identified, and it has not been identified whether the effective component is a single component or a complex component.
This can be used as it is or mixed with other raw materials, and the preparation can be selected in any form such as granules, tablets, capsules and pastes.
Moreover, you may mix | blend these in foodstuffs.

This time, the inventors experimented with pollen cargo from the Extremadura region of Spain. Most of the pollen collected is cistus, a plant belonging to the genus Godiaoi.
The analysis results of this pollen load are shown in Tables 1 to 4. These tests were performed using the general method for food analysis.

  Various raw materials including the above-mentioned pollen load were filled in capsules (No. 1 from Pullulan) in the blending amounts shown in Table 5, and the effectiveness evaluation test was performed. The placebo used dextrin instead of the pollen load in Table 5.

Twelve people with hay fever were randomly divided into two groups, one group taking capsules filled with pollen, and the other group taking 4 capsules of placebo daily.
Blood was collected before taking the test product, and the number of eosinophils in the blood was measured.
Blood was collected in the same manner during and after intake of the test product, and the number of eosinophils was measured. About pollen scattering amount, pollen scattering near Ise city using Mie University School of Medicine otolaryngology homepage, Mie pollen information (URL: http://www.medic.mie-u.ac.jp/kafun/) Quoted quantity. In addition, a questionnaire survey was conducted at the end of the study to confirm whether symptoms had improved compared to last year.
(The test was conducted from January 2009 to May 2009.)
The results are shown in Tables 6 and 7.

In 2009, the amount of pollen scattering was higher in the suburbs of Ise City than last year, and in the placebo group, there were four people who had worse symptoms than last year. Four people were found to be highly effective against hay fever. This shows that pollen loading suppresses eosinophil activation as shown in Table 5.
It was found that pollen cargo can be used as an eosinophil activation inhibitor or a food for suppressing eosinophil activation.

Claims (3)

  Eosinophil activation inhibitor containing pollen cargo as an active ingredient   2. The eosinophil activation inhibitor according to claim 1, wherein the pollen load is a pollen load mainly composed of pollen of a plant belonging to the genus Godiaoi.   Food for inhibiting eosinophil activation containing pollen cargo as an active ingredient