JP2011068630A - Composition used for preventing and treating periodontal disease - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a drug which destructs biofilms formed by periodontal disease-related bacteria, kills periodontal disease bacteria, and controls the formation of the biofilms. <P>SOLUTION: The effective component of the composition for the oral cavity which destructs biofilms, kills periodontal disease bacteria, and controls the formation of biofilms is a highly alkaline solution having a pH of ≥12 obtained by preparing a 0.1-0.2% aqueous solution of calcined shell calcium. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

The present invention relates to a composition for oral cavity that is excellent in periodontitis and halitosis suppression effects and is effective in preventing or treating periodontal disease, and further in preventing or suppressing halitosis.

Periodontal disease is a disease in which bacteria collectively called “periodontal disease bacteria” are infected in the oral cavity, forming a structure called dental plaque (plaque) and causing inflammation. The substance of dental plaque is a biofilm made up of various substances (proteins, polysaccharides, etc.) secreted by bacteria outside the cell, and the bacteria in this are protected from phagocytic cells and antibodies, and also have toxins inside. It is known to exhibit behavior such as release and destruction of periodontal tissue. Periodontal disease is not caused by one type of bacteria but is caused by multiple infections of multiple types of bacteria. Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, etc. are known as the main bacterial species . Eikenella corrodens is also known as a periodontal disease-related bacterium that proliferates in an opportunistic manner.

For prevention of periodontal disease, it is most important to prevent oral bacteria from forming dental plaque with daily tooth brushing. Will be formed. The biofilm causing periodontal disease mainly affects the surface of the teeth or roots, and the gums face this biofilm and cause symptoms such as swelling.

Drugs that reduce gum swelling are only treatments to relieve symptoms and not a fundamental treatment to remove the cause. Even if an antibiotic (suppuration) is used, it is difficult for the drug to penetrate into the biofilm, so a concentration 100 to 500 times higher than that used for a single bacterium is required. This will cause stronger side effects on the body. At present, many commercially available dentifrices and those used in dental treatment include deleterious substances, and even if periodontal disease bacteria can be sterilized, the influence on the living body is ignored. Moreover, although medicines by Chinese medicine such as catechin can be expected to eliminate bacteria in the oral cavity but cannot penetrate into the biofilm, it is not necessary to completely sterilize the periodontal disease bacteria in the biofilm.

Moreover, even if the dental plaque is removed at the dental clinic, it is only temporary and a dental plaque is formed again for those who cannot fully brush their teeth. These reasons are the major factors that make it difficult to prevent and treat periodontal disease.

Therefore, it has been desired to develop a therapeutic agent for periodontal disease prevention or periodontal disease that can be easily used by individuals, can sterilize periodontal bacteria in a biofilm, and is safe for the living body.

Patent No. 3284402 Composition for preventing or treating periodontal disease JP 2003-519167 A Method and Composition for Inhibiting Adhesion by Microorganisms Use of olive oil in the preparation of oral hygiene products to remove or reduce plaque and / or bacteria caused by bacteria in the oral cavity Composition containing JP 2005-533864 lactoferrin JP-A 2000-256155 Oral composition Japanese Patent Publication No. 7-25670 anti-periodontal disease agent Japanese Patent Publication No. 8-13738 plaque remover and calculus deposition inhibitor WO2003 / 094878 gallocatechin gallate-containing composition Composition for inhibiting adhesion of periodontal disease-causing bacteria JP-A-6-56687 plaque remover and calculus deposition inhibitor JP 2004-315414 calculus formation inhibitor Azakami H. et al. et al. 2006. Biosci. Biotechnol. Biochem. 70: 441-446. Rezai-Zadeh K.M. et al. 2005. J. et al. Neurosci. 25 (38): 8807-14. Yamada M. et al. et al. 2002. J. et al. Med. Microbiol. 51 (12): 1080-89. Djordjevic D.D. et al. 2002. Appl. Environ. Microbiol. 68: 2950-58. DENTAL TODAY Academic Form 2000.4.1: No. 1Comparing the permeability of various calcium hydroxide agents

In view of the above situation, the present inventor has developed a drug that more effectively suppresses periodontal disease in the human oral cavity, a plurality of periodontal pathogens are involved in the initial stage of biofilm formation, and then biofilm It was speculated that major periodontal bacteria such as Streptococcus mutans and Porphyromonas gingivalis propagated under the condition protected by, and formed strong plaque and tartar.

Therefore, the present inventors first examined a drug that destroys a biofilm.

As a result, it has been surprisingly found that an aqueous solution of calcined shell calcium such as scallop has an effect of destroying biofilm cells in the oral cavity, and the present invention has been completed.

Therefore, the present invention comprises the following aspects.
(1) The first aspect of the present invention is a biofilm destruction and activity inhibitor containing calcined shell calcium as an active ingredient.
(2) The second aspect of the present invention is a biofilm production inhibitor in the oral cavity containing the biofilm destruction and activity inhibitor as described in the first aspect as active ingredients.
(3) A third aspect of the present invention is a dental agent containing the biofilm formation inhibitor according to the second aspect as an active ingredient.
(4) A fourth aspect of the present invention is a therapeutic and preventive agent for periodontal disease comprising the biofilm activity inhibitor described in the first aspect or the second aspect as an active ingredient.

By utilizing the present invention, it becomes possible to destroy and effectively sterilize a biofilm that is an aggregate of a plurality of periodontal disease bacteria, and thus easily suppress the growth of other periodontal disease bacteria. Can prevent dental plaque causing periodontal disease and bad breath.

The greatest point of the present invention is to inhibit the activity of dental plaque, so that shell calcined calcium has a specific effect, specifically, by destroying and sterilizing biofilm cells in the oral cavity, It exists in the point which discovered that the formation was suppressed.

Shell-calcined calcium is well known for safety to living bodies, such as being commonly used as a food additive.

Calcium hydroxide has been widely used in endodontic therapy, and in applications such as apexification, it has been attracting attention because permeation into the periapical tissue may be related to the therapeutic effect. Yes.

It is also known that calcined shell calcium is a highly alkaline solution with a pH of 12 or more when made into a 0.1% aqueous solution and has a bactericidal effect against many bacteria such as Escherichia coli, Salmonella and ringworm.

Moreover, by making the shell calcined calcium into a 0.1 to 0.2% aqueous solution, it becomes highly alkaline with a pH of 12 or more, and the biofilm mainly composed of protein is destroyed.

However, despite these effects, the calcined shell calcium was rarely used for periodontal disease prevention and periodontal disease treatment.
Therefore, the specific action and effect of the calcined shell calcium has not been known at all.

The feature of the present invention is to destroy biofilms and kill periodontal bacteria by using calcined calcium shell as an active ingredient.

Examples of the present invention are shown below, but the present invention is not limited to the examples.

An aqueous solution containing 0.1 to 0.2% of calcined calcium such as scallops in a glass is prepared.

Gently gargle for about 1 minute with the calcium aqueous solution made in the above manner in the mouth.

While soaking the toothbrush in the aqueous calcium solution in the cup, brush the teeth with a focus on the boundary between the teeth and the gums. The tooth brushing time at this time is preferably 3 minutes or more.

Gargle with the aqueous calcium solution in the cup while brushing your teeth.

After finishing brushing with a toothbrush, use an interdental brush to brush between the teeth.

Finally, use a toothbrush to polish the tongue, which is the biggest cause of bad breath, without damaging the tongue.

Tap water into the cup, gargle multiple times to wash away the aqueous calcium solution in the oral cavity, and return the oral pH to neutral.

The biofilm inhibitor provided by the present invention is capable of effectively destroying and suppressing biofilms, and today, the importance of preventing periodontal disease and treating bad breath is recognized in the oral hygiene industry and the like. It is possible to use.

Furthermore, by using the biofilm inhibitor provided by the present invention in the field of dentistry, biofilms that cause periodontal diseases can be more effectively destroyed, and patients suffering from many bad breath and periodontal diseases It becomes possible to save.

Claims (3)

A composition for oral cavity that destroys a biofilm, comprising a highly alkaline solution having a pH of 12 or more obtained by making calcined shell calcium into a 0.1 to 0.2% aqueous solution. An oral cavity composition containing a highly alkaline solution having a pH of 12 or more obtained by making calcined shell calcium into an aqueous solution of 0.1 to 0.2% and suppressing biofilm formation. An oral composition comprising a highly alkaline solution having a pH of 12 or more obtained by making calcined shell calcium into a 0.1 to 0.2% aqueous solution, wherein the oral bacteria are sterilized or sterilized.