JP2011067265A - Prefilled syringe and composite prefilled syringe - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a prefilled syringe and a composite prefilled syringe, capable of independently storing and preserving contents safely and securely without requiring a complicated mechanism for preserving the contents, and capable of sufficiently mixing the contents within the syringe and discharging the mixture easily and smoothly with excellent reliability. <P>SOLUTION: The prefilled syringe 10 includes a cylinder 11, a plunger 15, a discharge-side gasket 12c, an intermediate gasket 12b, a pressure-side space 13a, an intermediate space 13b, and the contents 18 included in the pressure-side space and/or intermediate space. The prefilled syringe 10 also includes a bypass 14b formed in the intermediate space and discharge-side space. Communication between the pressure-side space and intermediate space and communication between the intermediate space and discharge-side space are made via the bypass by pressing the plunger, so that the contents flowing into the discharge-side space are discharged to outside of the cylinder. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

The present invention relates to a prefilled syringe and a composite prefilled syringe that can individually accommodate a plurality of contents.
More specifically, the present invention does not require complicated mechanisms for separation, mixing, and ejection, and (1) each content can be stored and stored individually safely and securely during storage. (2) In use, the present invention relates to a prefilled syringe and a composite prefilled syringe that can sufficiently mix the contents in the syringe without taking out the contents outside the syringe, and that can easily and smoothly discharge the contents with good reliability. .

  Generally, compositions used by mixing multiple types of ingredients include dental materials, medical adhesives such as surgical adhesives, and other materials such as adhesives, sealing agents, and hair dyes. Are known. Such a viscous material is used in various applications after a chemical reaction (curing reaction or the like) is started by mixing a plurality of components. Therefore, depending on the case, it is necessary to perform a mixing operation using a kneading plate or a mixing container and a mixing tool such as a bar or a spatula immediately before use.

  In recent years, various manufacturers have commercialized mixing capsules having a separation chamber for storing a plurality of components separately and a stirring unit for mixing these components. Such a mixed capsule can store a plurality of components separately in each separation chamber during storage. In addition, when the user uses, for example, the partition between the separation chambers separating each component is broken, and the separation chamber is brought into a conductive state, so that each component is mixed and the target mixture is obtained. Can be prepared.

  In particular, in the dental field, such a mixed capsule is widely used, and during storage, the powder component and the liquid component are separately stored in a separation chamber, and during use, these components are usually mixed in a stirring unit. And the dental material is prepared. Further, for example, the completely mixed dental material is directly dispensed into a work area such as a dental caries via a discharge port formed integrally with the mixing capsule.

  For example, Patent Document 1 discloses a mixed capsule particularly for preparing dental materials. The mixing capsule includes a cartridge, a dispensing port, a piston movably disposed within the cartridge, a sealed main chamber for receiving a first component, and a second defined in the piston. An auxiliary chamber for receiving the components; at least one movable body; and a separator that partitions the auxiliary chamber from the main chamber and can be penetrated by the movable body.

  In addition, the movable body is disposed in the main chamber when the separator is closed, and during the dispensing operation, the movable body can move to the auxiliary chamber as a moving body so that the movable body can move to the auxiliary chamber. A movable body is designed.

US Patent Application Publication No. 2003/0136799

However, the conventional mixing capsule including the mixing capsule described in Patent Document 1 requires a complicated mechanism for separating each component, mixing the components, and discharging the mixture.
Therefore, as a result of intensive studies to solve the above problems, the present inventors have found that the conventional problems can be solved by a configuration and mechanism completely different from those of the conventional mixed capsules.

  That is, the present invention does not require a complicated mechanism for separation, mixing, and ejection, and (1) each content can be stored and stored individually safely and securely during storage, and (2) when used. The present invention provides a prefilled syringe and a composite prefilled syringe that can sufficiently mix the contents in the syringe without taking out the contents outside the syringe, and that can easily and smoothly discharge the contents with good reliability. This is the issue.

The prefilled syringe and the composite prefilled syringe according to the present invention are as follows.
The prefilled syringe of the present invention (prefilled syringe (1)) includes the following (1) to (9), and in at least one intermediate space, a bypass part for allowing conduction between the pressing side space and the intermediate space (A) is a prefilled syringe in which a bypass part (b) for enabling conduction between the intermediate space part and the discharge side space part is formed in the discharge side space part, and the plunger part is pressed By the operation, the intermediate gasket part positioned on the pressing side from the bypass part (a) moves to the discharge side, and the pressing side surface of the intermediate gasket part passes through the pressing side end of the bypass part (a). When the pressure side space portion and the intermediate space portion are in a conductive state via the bypass portion (a), the discharge side gasket portion moves to the discharge side and the pressure side surface of the discharge side gasket portion When passing through the pressing side end of the bypass part (b), the intermediate space part and the discharge side space part are brought into conduction via the bypass part (b), and further, the content that has flowed into the discharge side space part It is characterized in that the object is formed so as to be discharged to the outside of the cylindrical body through the discharge portion.

(1) Cylindrical body (2) provided with a discharge part having the most discharge side wall surface located on the most discharge side and a discharge port for discharging contents The plunger part (3) inserted into the cylinder In the body, the pressure side gasket part (4) located on the discharge side from the plunger part In the cylinder, the discharge side gasket part (5) located between the pressure side gasket part and the discharge part In the cylinder, the pressure side At least one intermediate gasket portion (6) located between the gasket portion and the discharge side gasket portion (6) in the cylinder, and a pressing side space portion (7) defined by the pressing side gasket portion and the intermediate gasket portion, Discharge side space part (8) defined by discharge side gasket part and discharge part Intermediate space part (9) Press side space part and / or intermediate space defined by intermediate gasket part and discharge side gasket part in cylinder Contents included in the department

  Further, the prefilled syringe (1) of the present invention has a plurality of intermediate space portions, and at least one of the plurality of intermediate space portions includes an intermediate space portion on the discharge side and an intermediate space portion on the pressing side. A bypass portion (a ′) is formed, and the intermediate gasket portion located on the pressing side of the intermediate space portion on the discharge side moves to the discharge side by the pressing operation of the plunger portion, When the surface on the pressing side of the intermediate gasket portion passes through the pressing side end of the bypass portion (a ′) of the intermediate space portion, the intermediate space portion on the discharge side passes through the bypass portion (a ′). It is preferable that the intermediate space on the pressing side is formed in a conductive state.

  In the prefilled syringe (1) of the present invention, the length of the bypass portion in the long axis direction is shorter than the length of the space portion in which the bypass portion is formed in the long axis direction. It is preferable that the thickness of the gasket portion located on the pressing side is longer than the thickness in the major axis direction.

Moreover, as for the prefilled syringe (1) of this invention, it is preferable that the shape of the said bypass part is groove shape.
Further, the prefilled syringe (1) of the present invention has one intermediate space part, and the intermediate space part contains a low-active substance or an inert substance as contents, and the pressing side space and the discharge side space part. The contents contain an active substance or have a plurality of intermediate spaces, and at least one of the plurality of intermediate spaces contains a low activity substance or an inert substance as contents. In addition, it is preferable that an active substance is contained as a content in the intermediate space part or the pressure side space part located on both sides of the intermediate space part containing the low activity substance or the inert substance.

  The prefilled syringe of the present invention (prefilled syringe (2)) includes a cylinder having a discharge part for discharging the contents, and a gasket that can slide in a liquid-tight or air-tight manner in the major axis direction of the cylinder part. And a plunger portion for pressing the gasket portion, wherein the cylindrical body is made of a flexible material, and the contents are sealed inside the cylindrical body. When the tube part is bent, the easily breakable ampoule breaks without breaking the tube part, and the contents are broken into the tube part from the breakable easily breakable ampoule. It is formed so that it can be leaked and can be discharged from the discharge portion to the outside of the cylinder body by a pressing operation of the plunger portion.

Moreover, it is preferable that the prefilled syringe (2) of the present invention further includes a solid content inside the cylindrical body.
Further, in the prefilled syringe (2) of the present invention, a filter for preventing the broken pieces of the easily destructible ampule from being discharged is installed on the discharge part side of the easily destructible ampule in the cylinder, It is preferable that a solid content is contained in a space defined by the filter and the discharge unit.

In the prefilled syringe (2) of the present invention, it is preferable that a filter for preventing the breakable pieces of the easily destructible ampule from discharging covers the easily destructible ampule.
In the prefilled syringe (2) of the present invention, the material of the easily destructible ampoule is preferably glass.

In the prefilled syringe (2) of the present invention, the material of the easily destructible ampoule is preferably breakable glass.
The composite prefilled syringe (prefilled syringe (3)) of the present invention includes an outer cylinder part (A) having the following (A1) to (A4) and an inner cylinder part (B) having the following (B1) to (B7). The pressing side gasket portion (a) and the inner cylinder portion (B) are sequentially inserted into the cylindrical body (a) toward the discharging portion (a), and the discharging portion (b) is the pressing side gasket. A bypass portion (b ₂ ) is formed through the portion (a) and enabling the pressure-side space portion (b) and the discharge-side space portion (b) to conduct in the discharge-side space portion (b). It is a composite prefilled syringe, and by the pressing operation of the plunger part,
When the discharge-side gasket portion (b) moves to the discharge side and the pressing-side surface of the discharge-side gasket portion (b) passes through the pressing-side end portion of the bypass portion (b ₂ ), the bypass portion ( b ₂ ), the discharge-side space (b) and the pressure-side space (b) are brought into conduction, and the content (b) flows into the discharge-side space (b). b) flows into the space part (a) via the discharge part (b), and the contents (a) together with the contents (b) are discharged outside the outer cylinder part via the discharge part (a). It is formed so that it can be performed.

(A1) Cylindrical body (a) provided with a discharge part (a) having the most discharge side wall surface (a) located on the most discharge side and the discharge port (a) for discharging the contents
(A2) Press side gasket part (a) located on the pressing side of the discharge part (a) in the cylindrical body (a)
(A3) In the cylindrical body (a), a space part (a) defined by the pressing side gasket part (a) and the discharge part (a)
(A4) Contents (a) contained in space (a)
(B1) Cylindrical body (b) having a discharge part (b) having the most discharge side wall surface (b) located on the most discharge side and the discharge port (b) for discharging the contents
(B2) Plunger part (b) inserted into the cylinder (b)
(B3) Press side gasket portion (b) located on the discharge side of the plunger portion (b) in the cylindrical body (b)
(B4) Discharge side gasket portion (b) located between the pressing side gasket portion (b) and the discharge portion (b) in the cylindrical body (b)
(B5) Press side space (b) defined by the press side gasket part (b) and the discharge side gasket part (b) in the cylindrical body (b).
(B6) The discharge side space (b) defined by the discharge side gasket part (b) and the discharge part (b) in the cylindrical body (b).
(B7) Contents (b) contained in the pressing side space (b)

Moreover, the composite prefilled syringe (prefilled syringe (3)) of the present invention includes an outer cylinder part (A) having the following (A1) to (A4) and an inner cylinder part (B) having the following (B1) to (B9). ), The pressure side gasket part (a) and the inner cylinder part (B) are inserted into the cylinder body (a) in this order toward the discharge part (a), and the discharge part (b) is pressed. A bypass portion (b ₁ ) for penetrating the side gasket portion (a) and enabling conduction between the pressing side space portion (b) and the intermediate space portion (b) in at least one intermediate space portion (b), In the discharge-side space portion (b), a composite prefilled syringe in which a bypass portion (b ₂ ) for enabling electrical connection between the intermediate space portion (b) and the discharge-side space portion (b) is formed. , pressed by a plunger portion (b), from the bypass section (b ₁₎ When the intermediate gasket portion located pressure side (b) is moved to the discharge side, the surface on the pressure side of the intermediate gasket (b) is passed through the pressing end of the bypass section (b _1), said bypass The intermediate space portion (b) and the pressing side space portion (b) are brought into conduction via the portion (b ₁ ), the discharge side gasket portion (b) moves to the discharge side, and the discharge side gasket portion (b) when the surface on the pressure side has passed the pressing end of the bypass section (b ₂₎ of the intermediate space via the bypass section (b ₂₎ (b) and the discharge-side space and (b) is The content (b) flows into the discharge side space (b) and the content (b) flows into the space (a) via the discharge unit (b). The contents (a) together with the object (b) can be discharged to the outside of the outer cylinder part via the discharge part (a). Characterized in that it is formed.

(A1) Cylindrical body (a) provided with a discharge part (a) having the most discharge side wall surface (a) located on the most discharge side and a discharge port for discharging the contents
(A2) Press side gasket part (a) located on the pressing side of the discharge part (a) in the cylindrical body (a)
(A3) In the cylindrical body (a), a space part (a) defined by the pressing side gasket part (a) and the discharge part (a)
(A4) Contents (a) contained in space (a)
(B1) Cylindrical body (b) provided with a discharge part (b) having the most discharge side wall surface (b) located on the most discharge side and a discharge port for discharging the contents
(B2) Plunger part (b) inserted into the cylinder (b)
(B3) In the cylinder (b), the pressing side gasket portion (b) located on the discharge side from the plunger portion (b)
(B4) Discharge side gasket portion (b) located between the pressure side gasket portion and the discharge portion in the cylindrical body (b)
(B5) Intermediate gasket portion (b) located between the pressing side gasket portion (b) and the discharge side gasket portion (b) in the cylindrical body (b).
(B6) In the cylindrical body (b), the pressure side space (b) defined by the pressure side gasket part (b) and the intermediate gasket part (b)
(B7) The discharge side space (b) defined by the discharge side gasket portion (b) and the discharge portion (b) in the cylindrical body (b).
(B8) An intermediate space portion (b) defined by the discharge side gasket portion (b) and the intermediate gasket portion (b) in the cylindrical body (b).
(B9) Contents (b) contained in the pressure side space (b) and / or the intermediate space (b)

Moreover, the prefilled syringe (3) of the present invention has a plurality of intermediate space portions (b), and at least one of the plurality of intermediate space portions (b) has an intermediate space portion on the discharge side ( b) and a bypass portion (b ₃ ) for enabling electrical connection between the pressing side intermediate space portion (b) and a pressing operation of the plunger portion to press the discharge side intermediate space portion (b). When the intermediate gasket portion (b) positioned on the side moves to the discharge side and the pressing side surface of the intermediate gasket portion passes the pressing side end of the bypass portion (b ₃ ) of the intermediate space portion The discharge-side intermediate space (b) and the pressure-side intermediate space (b) are preferably formed in a conductive state via the bypass (b ₃ ).

Moreover, as for the prefilled syringe (3) of this invention, the said space part (a) has the following (A5)-(A7), and the content (a) is contained in the following press side space part (a). , A bypass part (a) for enabling electrical connection between the pressing side space part (a) and the discharge side space part (a) is formed, the discharge side gasket part (a) moves to the discharge side, When the pressure side surface of the discharge side gasket portion (a) passes through the pressure side end portion of the bypass portion (a), the pressure side space portion (a) and the discharge side space portion (a) It is preferably formed so as to be able to be in a conductive state via the part (a).
(A5) Discharge side gasket portion (a) located between the pressing side gasket portion (a) and the discharge portion (a) in the cylindrical body (a)
(A6) In the cylindrical body (a), the pressure side space (a) defined by the pressure side gasket part (a) and the discharge side gasket part (a)
(A7) In the cylindrical body (a), the discharge part side space part (a) defined by the discharge side gasket part (a) and the discharge part (a)

  The prefilled syringe and the composite prefilled syringe of the present invention do not use a complicated and expensive mechanism, and (1) each content is individually and safely stored without being mixed with each other during storage. (2) When used, it is not necessary to take out the contents from the syringe, and the contents can be sufficiently mixed in the syringe. Furthermore, the contents can be easily and smoothly combined with good reliability. It can be discharged.

FIG. 1 is a cross-sectional view showing one embodiment of a prefilled syringe (prefilled syringe (1)) according to the present invention. FIG. 2 is a cross-sectional view showing an embodiment of the prefilled syringe (prefilled syringe (1)) according to the present invention. FIG. 3 is a cross-sectional view showing a groove-shaped bypass portion. FIG. 4 is a cross-sectional view showing one embodiment of the prefilled syringe (prefilled syringe (2)) according to the present invention. FIG. 5 is a cross-sectional view showing an embodiment of the prefilled syringe (prefilled syringe (2)) according to the present invention. FIG. 6 is a cross-sectional view showing one embodiment of a composite prefilled syringe (prefilled syringe (3)) according to the present invention. FIG. 7 is a cross-sectional view showing one embodiment of a composite prefilled syringe (prefilled syringe (3)) according to the present invention. FIG. 8 is a cross-sectional view showing an embodiment of a composite prefilled syringe (prefilled syringe (3)) according to the present invention.

The prefilled syringe and composite prefilled syringe according to the present invention will be specifically described below with reference to the drawings.
For convenience of explanation, the prefilled syringe and the composite prefilled syringe according to the present invention are roughly classified into prefilled syringes (1) to (3), which will be described separately.

[Prefilled syringe (1)]
It demonstrates concretely using FIGS. 1-2 by which the prefilled syringe (1) of this invention is illustrated.

  First, number 10 in FIG. 1 shows one mode of the prefilled syringe (1). The cylindrical body 11 constituting the prefilled syringe (1) 10 has the most discharge side wall surface and contents on the most discharge side of the discharge side 11b when 11a and 11b are respectively set to the pressing side and the discharge side in the long axis direction. And a discharge portion having a discharge port for discharging the liquid.

  The inner surface of the cylindrical body 11 is kept in a sealed state (liquid-tight state / air-tight state) with the gasket portions (press-side gasket portion 12a, intermediate gasket portion 12b, discharge-side gasket portion 12c) except for a bypass portion described later. It can slide smoothly. Therefore, it is preferable that the inner surface of the cylindrical body 11 has a shape that is parallel to the major axis direction and has no unevenness.

Moreover, it does not specifically limit as a material of the cylinder 11, For example, glass, Teflon (trademark), a polypropylene etc. are mentioned.
The discharge port 16 a of the discharge unit 16 has a function of discharging contents from the inside of the cylinder 11 to the outside of the cylinder 11. As long as it has such a function, the shape of the discharge port is not particularly limited, and can be appropriately changed according to the purpose of use and application.

  For example, the cross-sectional shape of the discharge port is preferably approximately circular, but may be wide. In order to further promote mixing and stirring of the contents in the discharge port, the discharge port may be provided with an uneven shape on its inner wall, or a maze-shaped route may be formed.

  In the prefilled syringe (1) 10 shown in FIG. 1, the discharge port 16a is fastened by the clasp 17. However, even if the discharge part and the cylinder are directly engaged without using the clasp. Alternatively, the cylindrical body and the discharge portion may be integrally formed. In the former case, as shown by the number 16b in FIG. 1, the surface on the pressing side of the clasp is the most discharge side wall surface.

  Reference numeral 15 denotes a plunger portion that is inserted into the cylinder on the pressing side 11 a of the cylinder 11. By the operation (pressing operation) of pressing the plunger portion 15 from the pressing side 11a to the discharge side 11b, the pressing side gasket portion 12a is moved from the pressing side 11a to the discharge side 11b, and the contents contained in each space portion are discharged to the discharge side. 11b, and finally discharged from the discharge portion 16 to the outside of the cylindrical body 11.

  In FIG. 1, the plunger portion 15 is illustrated as being connected to the pressing-side gasket portion 12a. The plunger portion preferably has such a configuration, but is not limited thereto. Is not to be done.

For example, the plunger portion may have a structure in which the pressing-side gasket portion and the plunger portion are not connected but are simply in contact with each other.
In addition, the pressing operation is usually an operation by manually pressing the plunger portion, but instead, an operation using fluid pressure or electromagnetic means may be used.

Reference numerals 12 a and 12 c in FIG. 1 indicate a pressing side gasket portion positioned on the pressing side 11 a of the cylindrical body 11 and a discharge side gasket portion positioned on the discharging side 11 b of the cylindrical body 11, respectively.
Reference number 12b indicates an intermediate gasket portion located between the pressing side gasket portion 12a and the discharge side gasket portion 12c.

  Further, in the cylindrical body 11, space portions (pressing side space portion 13 a, intermediate space portion 13 b, discharge side space portion 13) demarcated (partitioned) by the gaskets at both ends or by the discharge side gasket and the discharge portion. ′) Is included.

  Reference number 13a indicates a pressing side space portion, and is a space portion defined by the pressing side gasket portion 12a and the intermediate gasket portion 12b in the cylinder. Reference numeral 13b denotes an intermediate space portion, which is a space portion defined by the intermediate gasket portion 12b and the discharge side gasket portion 12c in the cylinder.

  The prefilled syringe (1) may have a single intermediate gasket portion 12b and a single intermediate space portion 13b as shown in FIG. 1, or a plurality of prefilled syringes (1) as shown in FIG. You may have intermediate gasket part 12b, 12b 'and several intermediate | middle space part 13b, 13b'. The number 13b in FIG. 2 is an intermediate space defined by the intermediate gaskets.

Further, reference numeral 13 ′ in FIG. 1 indicates a discharge side space portion, which is a space portion defined by the discharge side gasket portion 12c and the discharge portion 16 in the cylinder.
In the prefilled syringe (1) having a single intermediate space portion shown in FIG. 1, the pressing side space portion 13a and / or the intermediate space portion 13b contain contents.

  Similarly, in the prefilled syringe (1) having a plurality of intermediate space portions shown in FIG. 2, the pressing side space portion 13a and / or the intermediate space portions 13b and 13b ′ contain contents.

  Whether these spaces contain contents or no contents (that is, when the spaces are filled with air), these spaces are in a liquid-tight or air-tight state. Is held by. In addition, as will be described later, as long as the pressure side surface of the gasket portion does not pass through the pressure side end portion of the bypass portion, the contents of each space portion are mixed together, or the contents leak out of the cylindrical body, Or the foreign material from the outside of a cylinder does not mix.

  Further, as shown in FIG. 1B, by pressing the plunger portion 15, the gasket portions 12 a to 12 c and the space portions 13 a to 13 b can be moved to the discharge side 11 b to arbitrary positions. . Conversely, by stopping the pressing operation, the gasket portions 12a to 12c and the space portions 13a to 13b and 13 'can be stopped at arbitrary positions.

  Also, until the pressing side surface of each gasket passes the pressing side end of the bypass portion by the pressing operation, the rate of movement of each gasket portion may be the same or different. .

The rate of movement of each gasket part can be adjusted, for example, by selecting the material of each gasket part or adjusting the pressure of the contents contained in each space part.
Moreover, in each gasket part shown by numbering 12a-c of FIG. 1, although a substantially flat surface is illustrated as a shape of the surface of a press side and / or the surface of a discharge side, a concave surface or a convex surface may be sufficient. .

  The shape of the gasket part is preferably a substantially cylindrical or disk-shaped plug or piston having a plurality of ring-shaped convex portions. With such a shape, the frictional force generated when the gasket portion slides is reduced, and the portion where the gasket portion is in close contact with the inner wall of the cylinder is divided. Or airtight state can be stably maintained.

  The material of the gasket portion is not particularly limited as long as it is a material that can slide and stop while maintaining a liquid-tight or air-tight state in a space defined between the gasket portions in the cylinder. Examples of such materials include natural rubber, synthetic rubber, mixed rubber of natural rubber and synthetic rubber, Teflon (registered trademark), silicone rubber, and the like.

  The volume of each space portion is set according to the type and amount of the contents to be stored and filled, but is set larger than the amount of the contents, and after the contents are stored and filled in the space portion, In the remaining space, an inert gas such as nitrogen gas or argon gas or a fluid having low reactivity with respect to the contents (low reactive gas, low reactive liquid) may be enclosed. .

In addition, the volume of the discharge side space and the length in the long axis direction (indicated by L ₂ ′ in FIG. 1) take into account the total amount of contents contained in the pressure side space and / or the intermediate space. Are adjusted accordingly.

  Although not shown in FIG. 1, the discharge port 16a of the discharge unit 16 is sealed with a cap or the like before use (before pressing operation) in order to prevent foreign matters such as microorganisms and dust from the outside of the cylinder. It is preferable to keep it.

  A number 14a in FIG. 1 indicates a bypass portion (bypass portion (a)) for enabling electrical connection between the pressing side space portion 13a and the intermediate space portion 13b. Reference number 14b indicates a bypass portion (bypass portion (b)) for enabling electrical connection between the intermediate space portion 13b and the discharge-side space portion 13 ′.

  In the prefilled syringe (1) having a plurality of intermediate space portions shown in FIG. 2, the number 14a ′ is provided so that the discharge-side intermediate space portion 13b ′ and the press-side intermediate space portion 13b can be electrically connected. The bypass part (bypass part (a ')) is shown.

  In the prefilled syringe (1), when the plunger portion is pressed, the contents contained in the pressure side space portion and / or the intermediate space portion are discharged from the discharge portion to the outside of the cylindrical body through the following process. Is done. Hereinafter, this process will be described with reference to FIG.

First, by the pressing operation of the plunger portion 15, the intermediate gasket portion 12b located on the pressing side 11a from the bypass portion (a) 14a moves to the discharge side 11b. Then, the surface S ₁ on the pressure side of the intermediate gasket portion 12b has moved to the discharge side 11b is, when passing through the bypass section (a) 14a pressing end portion S ₂ of the bypass section (a) 14a Thus, the pressing side space portion 13a and the intermediate space portion 13b become conductive (FIG. 1B). That is, when the content is contained in the press side space 13a, the content flows from the press side space 13a to the intermediate space 13b.

Further, the discharge side gasket portion 12c moves to the discharge side 11b (FIG. 1C). When the pressure-side surface S ₁ ′ of the discharge-side gasket portion 12c passes through the pressure-side end S ₂ ′ of the bypass portion (b) 14b, the intermediate space portion 13b and the intermediate space portion 13b are interposed via the bypass portion (b) 14b. The discharge side space portion 13 ′ becomes conductive (FIG. 1D). That is, the contents contained in the pressing side space portion 13a and / or the intermediate space portion 13b flow into the discharge side space portion 13 ′ from the intermediate space portion 13b.

  Further, the contents flowing into the discharge side space portion 13 'are discharged from the discharge side space portion 13' to the outside of the cylindrical body 11 through the discharge portion 16 fixed by a clasp 17 or the like (FIG. 1 ( D) to (E)).

In the case where the surface S ₁ on the pressure side of the intermediate gasket portion 12b has passed the pressing end portion S ₂ of the bypass section (a) 14a, the contents (fluid) is the discharge side by bypassing the bypass section (a) 14a Therefore, the intermediate gasket portion 12b at this time is almost stopped (FIG. 1B). Furthermore, the surface S ₁ on the pressure side of the intermediate gasket portion 12b in the stop, in contact with the pressing-side gasket part 12a, starts to move again the intermediate gasket portion 12b of the stopped to the discharge side 11b (FIG. 1 (C) ).

Similarly, when the pressing-side surface S ₁ ′ of the discharge-side gasket portion 12c passes through the pressing-side end S ₂ ′ of the bypass portion (b) 14b, the contents (fluid) bypass the bypass portion (b) 14b. Then, since it moves to the discharge side space portion 13 ', the discharge side gasket portion 12c at this time is stopped (FIG. 1D). Further, when the pressing-side surface S ₁ ′ of the stopped discharge side gasket portion 12c contacts the intermediate gasket portion 12b, the stopped discharge side gasket portion 12c starts to move to the discharge side 11b again (FIG. 1 ( E)).

  Further, the prefilled syringe (1) shown in FIG. 2 has a plurality of intermediate space portions 13b and 13b ′, and each of the plurality of intermediate space portions 13b and 13b ′ has a bypass portion (a) 14a and a bypass portion ( a ') 14a' is formed.

  Here, the bypass part (a) 14a is a bypass part for electrically connecting the pressing side space part 13a and the intermediate space part 13b located on the pressing side 11a. On the other hand, the bypass portion (a ′) 14a ′ is a bypass portion for electrically connecting the intermediate space portion 13b located on the pressing side 11a and the intermediate space portion 13b ′ located on the discharge side 11b.

When the prefilled syringe (1) has such a configuration, the process from the pressing operation until the contents are discharged is illustrated in FIG.
First, by the pressing operation of the plunger portion 15, the pressing-side space portion 13 a and the intermediate space portion 13 b are in a conductive state via the bypass portion (a) 14 a in the same manner as the prefilled syringe (1) shown in FIG. 1. (FIGS. 2A to 2B). Further, the intermediate gasket portion 12b ′ moves to the discharge side, and the pressing-side surface S _{1 ″ of the} intermediate gasket portion 12b ′ passes through the pressing-side end S _{2 ″ of} the bypass portion (a ′) 14a ′. Then, the intermediate space portion 13b on the pressing side and the intermediate space portion 13b ′ on the discharge side become conductive through the bypass portion (a ′) 14a ′ (FIG. 2C).

  In addition, when the pressure side surfaces of the intermediate gasket portions 12b and 12b ′ and the discharge side gasket portion 12c pass through the press side end portions of the bypass portions 14a, 14a ′ and 14b, respectively, the fluid bypasses the bypass portion. In order to move to the discharge side, the intermediate gasket portions 12b and 12b ′ and the discharge side gasket portion 12c are stopped. Further, when the surface on the pressing side of the stopped gasket portion comes into contact with the gasket portion located on the pressing side of the gasket portion, the stopped gasket portion moves again to the discharge side. (FIGS. 2C to 2E).

The shape of the bypass part of the prefilled syringe (1) of the present invention is not particularly limited as long as the space part can be electrically connected by the movement of the gasket part by the pressing operation as described above.
Examples thereof include a tubular bypass structure formed inside or outside the cylinder wall, and a groove formed on the cylinder wall. Among these, it is preferable that the bypass portion has a groove shape in that the structure is simple, it is easy to create, and a failure is unlikely to occur.

  Further, from the viewpoint of easy formation, as shown by the number 34 in FIG. 3A, the bypass portion has a groove shape in which the groove width 34 ′ gradually decreases toward the outer periphery 31 of the cylindrical body. It is preferable to have. In addition, as indicated by numbering 34a and 34b in FIG. 3B, a plurality of grooves may be provided as bypass portions.

  The width 34 ′ of the groove as the bypass portion is not particularly limited as long as it is large enough not to interfere with the conduction of the contents and small enough not to hinder the movement of the gasket portion. Further, the depth 34 ″ of the groove as the bypass portion may be formed deep enough to prevent the contents from being conducted.

  For example, in the plane perpendicular to the long axis direction of the cylinder, the width of the inner surface of the cylinder is larger than the width of the groove when compared with the width of projection by parallel rays from any direction. When measured along the inner circumference 31 ′ of the inner surface of the part, it is preferably 0.2 to 10 mm, more preferably 0.5 to 6 mm, and further preferably 1 to 4 mm.

  Ratio of groove width to the area of this bypass part (maximum cross-sectional area of the bypass part) when the area when the part where the bypass part of the cylindrical body is formed is perpendicular to the major axis direction (Maximum cross-sectional area of the bypass portion / groove width) is preferably 0.01 to 2 mm, more preferably 0.05 to 1 mm, and still more preferably 0.1 to 0.5 mm. The ratio (maximum cross-sectional area of the bypass portion / groove width) is the same as the value indicating the average groove depth when the groove as the bypass portion has the maximum cross-sectional area.

  The groove as the bypass part may be formed by inserting a cutting tool into the inner surface of the cylindrical body and cutting it, or after cutting the cylindrical part into the length and width of the groove, a shallow member is inserted by the depth of the groove. They may be formed by joining them. Alternatively, the groove may be formed by injection molding using a split type insert, or gas pressure is applied to the inside of the cylinder or the mold is pressed against the part in a state where the groove is heated and softened. By doing so, the groove may be formed by inflating to the outside.

  In addition, when a bypass part such as a tubular bypass structure or a groove is formed using a polymer, an adhesive, or the like, and the contents are included in the space where the bypass part is formed, the contents and the polymer In some cases, contact with an adhesive or the like may cause a problem such as a chemical reaction or a change in characteristics. In this case, as shown in FIG. 1, the above-described problem can be avoided if the contents are stored in a space portion where the bypass portion is not formed in the space portion such as the pressing side space 13a.

As shown in FIGS. 1 and 2, the length of the bypass portion (bypass portions (a), (a ′), (b)) in the major axis direction (indicated by L ₁ and L ₁ ′ in FIG. 1). However, the length (indicated by L ₂ and L ₂ ′ in FIG. 1) of the space portion in which the bypass portion is formed is shorter, and the gasket portion is positioned on the pressing side of the bypass portion. Longer than the thickness in the major axis direction (indicated by L ₃ and L ₃ ′ in FIG. 1).

  When the pressure side surface of the discharge side gasket portion does not pass through the pressure side end portion of the bypass portion (b), the intermediate space portion and the discharge side space portion are not in a conductive state. Therefore, the contents can be freely stirred in the intermediate space without being exposed to the outside of the cylindrical body and discharged.

Further, the total thickness in the major axis direction of each gasket portion located on the pressing side of the bypass portion (FIG. 1: the sum of L ₃ and L ₄ or the sum of L ₃ ′, L ₃ and L ₄ ), Alternatively, the length of the bypass portion in the long axis direction (L _{1 in} FIG. 1) is larger than the thickness in the long axis direction of one gasket portion (FIG. 1: L ₃ ′, L ₃ or L ₄ ). , L ₁ ′) is preferably small. By comprising in this way, it can prevent that the contents flow backward from the space part located in the discharge side to the space part located in the press side.

For example, as shown in FIG. 1A, the length L ₁ in the major axis direction of the bypass portion (a) 14a is the length of each gasket portion 12a, 12b located on the pressing side of the bypass portion (a) 14a. It is smaller than the sum (L ₃ + L ₄ ) of the thicknesses L ₃ and L ₄ in the axial direction. By having such a configuration, as shown in FIG. 1D, during the pressing operation, the space portion (pressing side) positioned on the pressing side from the space portion (intermediate space portion 13b) positioned on the discharge side. The backflow of the contents to the space 13a) can be prevented.

In addition, as stirring operation, a prefilled syringe (1) may be shaken by hand and a cylinder may be shaken, and vibration may be added with an ultrasonic vibration apparatus.
Alternatively, by reverse operation to the pressing operation, that is, the operation of pulling back the plunger portion 15 from the discharge side 11b to the pressing side 11a, the contents are caused to flow back from the discharge side space portion to the pressing side space portion one or more times. The contents can be stirred.

  As described above, the prefilled syringe (1) of the present invention has the bypass part (b) 14b, so that when the contents are mixed, the discharge part 16 is closed and opened in order to degas and prevent the contents from leaking. The agitation operation of the contents can be performed safely.

The contents contained in the pressing side space part and / or the intermediate space part are specifically exemplified in [Contents applied to prefilled syringe] described later.
Further, in order to reliably prevent the contents contained in the cylinder from being exposed to the outside of the cylinder, in the prefilled syringe (1) having one intermediate space, a low activity substance or It is preferable that an inert substance is contained, and that the active substance is contained as a content in the pressing side space and the discharge side space.

  In addition, in the prefilled syringe (1) having a plurality of intermediate space portions, at least one of the plurality of intermediate space portions has a low content as the contents in order to further ensure the isolation between the contents. It is preferable that the active substance or the inert substance is contained, and the intermediate space part or the pressing side space part 13a located on both sides of the intermediate space part containing the low-active substance or the inert substance, and the active substance is contained as the contents. .

  In addition, in FIGS. 1-2, although the content is contained in the press side space part 13a, intermediate | middle space part 13b, 13b ', and the discharge side space part 13' has shown the aspect which does not contain a content, The discharge-side space may contain contents.

  In the aspect in which the contents are included in the discharge side space part, it is preferable that a cap or the like for preventing the contents from leaking out from the discharge part is installed. In particular, the content contained in the discharge side space is preferably a solid content such as powder, and more preferably insoluble in the content contained in the intermediate space and / or the pressure side space. Or it is a powder which is hardly soluble.

  A prefilled syringe provided with a plurality of syringes for storing contents has been conventionally known, but its structure / mechanism (for example, a configuration in which a plurality of syringes are arranged in parallel) is complicated. In manufacturing a syringe, complicated molding is required. On the other hand, as above-mentioned, the prefilled syringe (1) of this invention can exhibit the following effects by having a structure and mechanism different from the conventional prefilled syringe.

(1) At the time of storage, each content can be stored and stored individually safely and securely without mixing a plurality of contents.
(2) At the time of use, it is not necessary to take out each content from the syringe, each content can be sufficiently mixed in the syringe, and further, the content can be discharged easily and smoothly with good reliability.

[Prefilled syringe (2)]
The number 40 of FIG. 4 shows one mode of the prefilled syringe (2) of the present invention. A prefilled syringe (2) 40 shown in FIG. 4 is slidable in a liquid-tight or air-tight manner in a long axis direction of the cylinder 41 having a discharge port 46 for discharging the contents. A gasket portion 42a and a plunger portion 45 for pressing the gasket portion 42a. Moreover, the cylinder 41 is comprised from a flexible material, and has the easily destructible ampules 43a and 43b in which the contents were enclosed in the cylinder 41. Furthermore, as shown in FIG. 4B, when the tube portion 41 is bent, the easily breakable ampoules 43a and 43b break without breaking the tube portion 41. And as shown in FIG.4 (C), the content 43ab leaks into the cylinder 41 from this breakable easily destructible ampule 43a ', 43b'. At this time, the prefilled syringe (2) 40 is formed so that it can be discharged from the discharge port 46 to the outside of the cylindrical body 41 by a pressing operation of the plunger portion 45.

  In addition, although the aspect shown by FIG. 4 is an example which has two easily destructible ampules, according to the intended purpose etc. of the prefilled syringe (2) of this invention, increasing the number of easily destructible ampules, It may be reduced.

Furthermore, the content is not limited to the easily destructible ampule, but may be accommodated and filled in a cylindrical body outside the ampule, which may be any of gas, liquid, and solid.
In the major axis direction of the cylindrical body 41, when the numbering 41a and 41b are the pressing side and the discharge side, respectively, the plunger portion 45 is pressed from the pressing side 41a to the discharge side 41b (pressing operation), thereby being easily destructible. The gasket portion 42a positioned on the pressing side 41a with respect to the ampoule can slide in a liquid-tight or air-tight manner in the long axis direction (from the pressing side 41a to the discharge side 41b) in the cylinder.

  Since the cylinder 41 is made of a flexible material, the cylinder 41 is not broken even in a bending operation of the cylinder described later. Examples of the flexible material that is a material of such a cylinder include polypropylene.

  The material of the gasket portion is not particularly limited as long as it is a material that can slide and stop inside the cylinder in a liquid-tight or air-tight state. Examples of such materials include natural rubber, synthetic rubber, mixed rubber of natural rubber and synthetic rubber, Teflon (registered trademark), silicone rubber, and the like.

In FIG. 4, the shape of the pressure side surface and the discharge side surface of the gasket portion is substantially flat, but may be a concave surface or a convex surface.
In the prefilled syringe (2) 40 shown in FIG. 4, the discharge port 46 is fastened by a clasp 47, but even if the discharge port and the cylinder are directly engaged without using the clasp. The cylinder and the discharge port may be integrally formed.

  Moreover, the gasket part 42a shown in FIG. 4 and the plunger part 45 as a pressing means are connected, and although it is preferable that it is comprised in this way, it is not specifically limited. For example, the plunger part may not be connected to the gasket part but may be a structure in which the plunger part is simply in contact. In addition, the pressing operation is usually an operation by manually pressing the plunger portion, but instead, an operation using fluid pressure or electromagnetic means may be used.

  The shape of the discharge port is not particularly limited as long as the contents inside the cylinder can be discharged to the outside of the cylinder by a pressing operation, and can be appropriately changed according to the purpose of use and application. For example, the shape of the cross section of the discharge port is preferably approximately circular, but may be wide, or an uneven shape may be provided on the inner wall of the discharge port to further promote mixing and stirring of the contents. However, a labyrinth path may be formed.

  In addition, as shown in FIG. 4, it is preferable that the filter 42b for preventing that the fragment of an easily destructible ampule discharges is installed in the cylinder inner side (pressing part side) of a discharge outlet. The filter is not particularly limited as long as it can prevent the breakable pieces of the easily destructible ampoule from being discharged. For example, a glass filter, a product obtained by firmly pressing and compressing absorbent cotton or the like is preferable. By having the filter, it is possible to prevent a crushed piece of an easily destructible ampoule generated by a bending operation described later from being discharged out of the cylinder.

  Further, such a filter may be installed on the discharge port side of the easily destructible ampoule in the cylinder as shown by reference number 52b in FIG. The prefilled syringe (2) shown in FIG. 5A is defined by a filter 52b and a discharge part 46 ″ having a discharge side wall surface 46 ′ and a discharge port 46 for discharging contents on the discharge side. Solid content 58a is contained in the space 58.

  Moreover, as shown to number 52b 'of FIG. 5 (B), the filter for preventing that the fragment of a breakable ampoule discharges may coat | cover the easily breakable ampoule. In FIG. 5B, the filter 52b ′ is not fixed to the inner surface of the cylindrical portion by an adhesive or a fixing member, but may be temporarily fixed to the pressing side by these.

  Since the filter has a filter as shown in FIGS. 5A to 5B, it is insoluble or hardly soluble in other flowable contents contained in the easily destructible ampule or in the cylinder. Even if the contents are difficult to pass, the contents can be discharged without causing problems such as clogging of the filter.

  As shown in FIG. 5B, solid contents 58a ′ such as powder may be stored in the easily destructible ampule and the inside 58 ′ of the cylinder outside the filter covering the ampule. Further, the easily breakable ampoule and the cylinder interior 58 ′ outside the filter covering the ampoule may be filled and filled with liquid and / or gas contents other than solid contents such as powder.

  In this case, in order to prevent contact between the inside of the cylinder and the outside of the cylinder, and to prevent leakage of liquid and / or gas contents, it is preferable that the discharge port is sealed by a sealing means. For example, as shown in FIG. 4, a cap 42 c for preventing leakage may be installed at the distal end portion on the ejection side of the ejection unit. The cap may be fitted or screwed to the discharge part, or a flip-up lid engaged with a hinge or an alternative form thereof, or an opening and a closing part can be selected in a revolver type. The clasp part which can be freely opened and closed may be used.

  In the prefilled syringe (2) of the present invention, as illustrated in FIG. 4, easily breakable ampoules 43a and 43b that can be broken by a bending operation are stored in the internal space 43 of the cylindrical portion 41. Yes.

  A number 41 ′ in FIG. 4B indicates a cylindrical body when the cylindrical body 41 in FIG. 4A is bent by, for example, human power (during a bending operation). Furthermore, reference numerals 43a ′ and 43b ′ in FIG. 4C indicate the easily destructible ampules 43a and 43b that are broken by the bending operation, respectively. As shown in FIGS. 4B to 4C, even when the operation (folding operation) of bending the prefilled syringe (2) is performed, the cylinder body 41 is made of a flexible material. , Not torn or cracked. On the other hand, because it is made of a material that can be broken, the easily destructible ampules 43a and 43b are broken as shown in FIG. 4C, and the content 43ab contained in the ampule is placed inside the cylinder. Leak.

  The material of the easily destructible ampule is not particularly limited as long as it is a breakable material as described above, and examples thereof include glass. A particularly preferable flexible material is a breakable glass such as borosilicate glass.

  Furthermore, the contents 43ab leaked from the easily destructible ampoules 43a and 43b are mixed as appropriate inside the cylinder, and by the pressing operation of the plunger part 45, the gasket part 42a moves from the pressing side 41a to the discharge side 41b, It is discharged to the outside of the cylinder through the discharge port 46.

The contents contained in the prefilled syringe (2) of the present invention are specifically exemplified in [Contents applied to a prefilled syringe] described later.
A prefilled syringe provided with a plurality of syringes for storing contents has been conventionally known, but its structure / mechanism (for example, a configuration in which a plurality of syringes are arranged in parallel) is complicated. In manufacturing a syringe, complicated molding is required. On the other hand, as above-mentioned, the prefilled syringe (2) of this invention can exhibit the following effects by having a structure and mechanism different from the conventional prefilled syringe.

(1) At the time of storage, each content can be stored and stored individually safely and securely without mixing a plurality of contents.
(2) At the time of use, it is not necessary to take out each content from the syringe, each content can be sufficiently mixed in the syringe, and further, the content can be discharged easily and smoothly with good reliability.

[Prefilled syringe (3)]
The prefilled syringe (3) of the present invention has a mode in which there are two spaces in the inner cylindrical portion (B) 610 as shown by a number 600 in FIG. 6 and a number 700 in FIG. It is roughly classified into an aspect having an aspect in which there are three or more space parts in the inner cylinder part (B) 610.

  As will be described later, both prefilled syringes (3) have structural differences in the gasket part and the space part of the inner cylinder part (B), and the other members and structures are common. Hereinafter, the prefilled syringe (3) of the present invention will be specifically described with reference to FIGS.

  Numbers 600 and 700 in FIGS. 6 to 7 show the composite prefilled syringe (prefilled syringe (3)) of the present invention. Numbering 620 indicates the outer cylinder part (A) constituting the prefilled syringe (3), and numbering 610 indicates the inner cylinder part (B).

6-7, the outer cylinder part (A) 620 has the following (A1)-(A4).
(A1) Cylindrical body (a) 621 provided with a discharge portion (a) 626 having an outermost discharge side wall surface (a) 626b located on the most discharge side and a discharge port (a) 626a for discharging contents.
(A2) Press side gasket part (a) 622a located on the press side of the discharge part (a) 626 in the cylindrical body (a) 621
(A3) A space portion (a) 623 defined by the pressing gasket portion (a) 622a and the discharge portion (a) 626 in the cylindrical body (a) 621.
(A4) Contents (a) 623 ′ included in the space (a) 623
The cylindrical body (a) 621 discharges the most discharge side wall surface 626b and the contents on the most discharge side of the discharge side 621b when the number 621a is the pressing side and the number 621b is the discharge side in the long axis direction. And a discharge portion 626 having a discharge port 626a.

  The shape of the discharge port of the discharge part (a) is not particularly limited, and can be appropriately changed according to the purpose of use and application. For example, the shape of the cross section of the discharge port is preferably approximately circular, but may be wide, and in order to further promote mixing and stirring of the contents in the discharge port, an uneven shape is formed on the inner wall of the discharge port. It may be provided or a maze-like route may be formed.

  6 to 7 indicate a pressing side gasket portion (a), and the numbering 623 indicates a space portion (a) defined by the discharge portion (a) 626 and the pressing side gasket portion (a) 622a. Is shown.

  In addition, as shown in FIGS. 6 to 7, in order to prevent foreign matter such as microorganisms and dust from the outside of the outer cylinder part (A) 620 and leakage of contents, discharge before use (before pressing operation) It is preferable that a cap 622b is installed at the discharge port 626a of the part (a) 626.

  The number 623 ′ indicates the content (a) included in the space (a) 623. The content (a) is not particularly limited, but is preferably a solid content such as powder. Also, the type of the content (a) is not particularly limited, but specifically, it will be described in detail in the section [Contents applied to prefilled syringe].

  6-7, in the cylinder (a) 621, the pressing side gasket part (a) 622a and the inner cylinder part (B) 610 are sequentially inserted toward the discharge part (a) 626. And the discharge part (b) 616 has penetrated the press side gasket part (a) 622a.

  The inner cylinder part (B) 610 of the prefilled syringe (3) 600 shown in FIG. 6 has the following (B1) to (B7). This inner cylinder part (B) 610 has a press side space part (b) 613 and a discharge side space part (b) 613 'as a space part.

(B1) Cylindrical body (b) 611 provided with a discharge part (b) 616 having the most discharge side wall surface (b) 616b located on the most discharge side and a discharge port (b) 616a for discharging contents.
(B2) Plunger part (b) 615 inserted into cylindrical body (b) 611
(B3) Press side gasket portion (b) 612a located on the discharge side of the plunger portion (b) 615 in the cylindrical body (b) 611
(B4) Discharge side gasket portion (b) 612c located between the pressure side gasket portion 612a and the discharge portion 616 in the cylindrical body (b) 611.
(B5) In the cylindrical body (b) 611, the pressure side space (b) 613 defined by the pressure side gasket part (b) 612a and the discharge side gasket part (b) 612c.
(B6) The discharge side space (b) 613 ′ defined by the discharge side gasket portion (b) 612c and the discharge portion (b) 616 in the cylinder (b) 611.
(B7) Contents (b) included in the pressure side space (b) 613
Moreover, the inner cylinder part (B) 610 of the prefilled syringe (3) 700 shown in FIG. 7 has the following (B1) to (B9). The inner cylinder part (B) 610 of this prefilled syringe (3) 700 has a press side space part (b) 713a, a discharge side space part (b) 713 ', and an intermediate space part (b) 713b as space parts.

(B1) Cylindrical body (a) 611 provided with a discharge part (a) 616 having the most discharge side wall surface (b) 616b located on the most discharge side and a discharge port (b) 616a for discharging contents.
(B2) Plunger part (b) 615 inserted into cylindrical body (b) 611
(B3) Press side gasket portion (b) 712a located on the discharge side with respect to the plunger portion (b) 615 in the cylindrical body (b) 611
(B4) Discharge side gasket portion (b) 712c located between the pressing side gasket portion 712a and the discharge portion 616 in the cylindrical body (b) 611
(B5) An intermediate gasket portion (b) 712b located between the pressing side gasket portion (b) 712a and the discharge side gasket portion (b) 712c in the cylindrical body (b) 611.
(B6) In the cylindrical body (b) 611, the pressing side space (b) 713a defined by the pressing side gasket (b) 712a and the intermediate gasket (b) 712b.
(B7) Discharge side space portion (b) 713 ′ defined by discharge side gasket portion (b) 712c and discharge portion (b) 616 in cylinder (b) 611
(B8) In the cylindrical body (b) 611, an intermediate space portion (b) 713b defined by the discharge side gasket portion (b) 712c and the intermediate gasket portion (b) 712b
(B9) Contents (b) contained in the pressure side space (b) 713a and / or the intermediate space (b) 713b

  The cylindrical body (b) 611 that constitutes the prefilled syringe (3) shown in FIGS. 6 to 7 has a long axis direction where the numbering 611a is the pressing side and the numbering 611b is the discharging side. A discharge part (b) 616 for discharging the contents from the inside of the inner cylinder (B) 610 to the space part (a) 623 is provided. The shape of the discharge port of the discharge portion (b) can be appropriately changed according to the purpose of use and application, as in the case of the above-described discharge portion (a). For example, the cross-sectional shape of the discharge port can be approximately circular or wide. For example, an uneven shape may be provided on the inner wall of the discharge port, or a labyrinth path may be formed in the discharge port.

Moreover, the prefilled syringe (3) illustrated by FIGS. 6-7 has the plunger part (b) 615 inserted by the cylinder (b) 611.
The plunger portions 615 illustrated in FIGS. 6 and 7 are respectively connected to pressing side gasket portions 612a and 712a described later. The plunger portion preferably has such a configuration, but is not limited thereto.

For example, the plunger portion may have a structure in which the pressing-side gasket portion and the plunger portion are not connected but are simply in contact with each other.
In addition, the pressing operation is usually an operation by manually pressing the plunger portion, but instead, an operation using fluid pressure or electromagnetic means may be used.

  The prefilled syringe shown in FIG. 6 is characterized in that the inner cylinder part (B) 610 has two space parts (pressing side space part and discharge side space part). Numbers 612a and 612c in FIG. 6 respectively indicate a pressing side gasket portion (b) positioned on the pressing side 611a of the cylindrical body (b) 611 and a discharge side gasket portion (b) positioned on the discharge side 611b. . Reference numeral 613 denotes a pressure side space (b) defined by the pressure side gasket portion (b) 612a and the discharge side gasket portion (b) 612c in the cylinder.

  Reference numeral 613 ′ indicates a discharge side space (b) defined by the discharge side gasket portion (b) 612c and the discharge portion (b) 616 in the cylinder. The pressing side space (b) 613 includes the contents (b).

In the prefilled syringe (3) 600 shown in FIG. 6, in the discharge side space (b) 613 ′, the pressing side space (b) 613 and the discharge side space (b) 613 ′ can be electrically connected. The bypass portion (b ₂ ) is formed (numbering 614b).

In the prefilled syringe (3) shown in FIG. 6, when the plunger portion 615 is pressed, the pressing side gasket portion 612a and the discharge side gasket portion 612c move to the discharge side in the cylinder. Then, the surface S ₁ on the pressure side of the discharge-side gasket part 612c 'is, the bypass section (b ₂₎ pressing end portion S ₂ of 614b' when passing through the through the bypass section (b ₂₎ 614b pressing The side space portion (b) 613 and the discharge side space portion (b) 613 ′ are brought into conduction. That is, the content (b) flows from the pressing side space (b) 613 into the discharge side space (b) 613 ′.

At this time, the contents (fluid) bypass the bypass part (b ₂ ) 614b and move to the discharge side space part (b) 613 ′, so that the discharge side gasket part (b) 612c is stopped. Further, when the discharge side gasket portion (b) 612c comes into contact with the pressing side gasket portion (b) 612a, the discharge side gasket portion (b) 612c moves to the discharge side again.

  The content (b) flowing into the discharge side space (b) 613 ′ flows into the space (a) 623 via the discharge portion (b) 616. Then, the content (a) 623 ′ is discharged together with the content (b) to the outside of the outer tube portion (A) 620 via the discharge portion (a) 626.

  The prefilled syringe (3) shown in FIG. 7 has at least three space portions (a press side space portion, a discharge side space portion, and a plurality of intermediate space portions) in the inner cylinder portion (B). Yes.

  Numbering numbers 712a, 712c, and 712b are respectively a pressing side gasket portion (b) positioned on the pressing side 611a of the cylindrical body (b) 611, a discharging side gasket portion (b) positioned on the discharging side, and a pressing side gasket portion ( The intermediate gasket part (b) located between b) and the discharge side gasket part (b) is shown.

  Reference numeral 713a indicates a pressing side space defined by the pressing side gasket portion (b) 712a and the intermediate gasket portion (b) 712b in the cylindrical body (b). Reference numeral 713 ′ indicates a discharge side space (b) defined by the discharge side gasket portion (b) 712c and the discharge portion (b) 616 in the cylinder. Further, reference numeral 713b indicates an intermediate space portion (b) defined by the intermediate gasket portion (b) 712b and the discharge side gasket portion (b) 712c.

In the prefilled syringe (3) as shown in FIG. 7, in at least one intermediate space portion (b), a bypass portion for enabling conduction between the pressing side space portion (b) and the intermediate space portion (b). (B ₁ ) is formed (numbering 614a in FIG. 7). Further, the prefilled syringe (3) is provided with a bypass portion (b ₂ ) for enabling electrical connection between the intermediate space portion (b) and the discharge side space portion (b) in the discharge side space portion (b). (Numbering 614b in FIG. 7).

In the prefilled syringe (3) 700 shown in FIG. 7, when the plunger portion 615 is pressed, the pressing side gasket portion (b) 712a and the intermediate gasket portion (b) 712b move to the discharge side in the cylinder. To do. Then, when the intermediate gasket (b) 712b presses the side surface of the (in FIG. 7 are denoted by S _1.) Is passing through the pressing end portion S ₂ of the bypass section (b _1), the bypass section (b ₁ ) The pressure side space (b) 713a and the intermediate space 713b are brought into conduction through 614a. That is, the content (b) flows from the pressing side space (b) 713a into the intermediate space (b) 713b. In addition, since the contents (fluid) bypass the bypass part (b ₁ ) 614a and move to the intermediate space part (b) 713b, the intermediate gasket part (b) 712b is stopped.

Furthermore, the surface S ₁ on the pressure side of the discharge-side gasket part 712c 'is, the bypass section (b ₂₎ pressing end portion S ₂ of 614b' when passing through the through the bypass section (b ₂₎ 614b intermediate The space portion 713b and the discharge side space portion 713 ′ are in a conductive state. Therefore, the content (b) flowing into the intermediate space portion (b) 713b flows from the intermediate space portion (b) 713b to the discharge side space portion (b) 713 ′ via the bypass portion (b ₂ ) 614b. . Then, the content (b) flows into the space (a) 623 from the discharge side space (b) 713 ′. Further, the content (a) 623 ′ together with the content (b) is discharged to the outside of the outer tube portion (A) 620 through the discharge portion (a) 626.

Moreover, although the prefilled syringe (3) as shown in FIG. 7 has one intermediate space part, the prefilled syringe (3) has a plurality of intermediate space parts (b), In at least one space portion of the intermediate space portion (b), a bypass portion (b ₃ ) for enabling electrical connection between the discharge-side intermediate space portion (b) and the pressing-side intermediate space portion (b) is provided. It may be formed. When having such a configuration, the intermediate gasket portion (b) located on the pressing side of the intermediate space portion (b) on the discharge side is moved to the discharge side by the pressing operation of the plunger portion, and the intermediate gasket portion pressing when the surface of the pressing side, passed through the pressing end of the bypass section of the intermediate space (b _3), through the bypass section (b _3), the intermediate space of the discharge side (b) The intermediate space (b) on the side is brought into conduction.

  In addition, in the prefilled syringe (3) shown in FIGS. 6 to 7, the inner surfaces of the cylindrical body (a) 621 and the cylindrical body (b) 611 are the gasket parts (FIG. 6: discharge side gasket part (a), discharge side Gasket part (b), pressure side gasket part (b), Fig. 7: discharge side gasket part (a), discharge side gasket part (b), pressure side gasket part (b), intermediate gasket part (b)) sealed It can slide smoothly while maintaining the state (liquid tight state / air tight state). That is, the inner surfaces of the cylindrical body (a) 621 and the cylindrical body (b) 611 are preferably parallel to the major axis direction and have a shape without unevenness, and the material is not particularly limited. , Glass, Teflon (registered trademark), polypropylene and the like.

  In the prefilled syringe (3) shown in FIGS. 6 to 7, the material of each gasket portion is slid in the cylinder in a liquid-tight or air-tight state in the cylinder (a) 611 or the cylinder (b) 621. The material is not particularly limited as long as the material can be moved and stopped. Examples of such materials include natural rubber, synthetic rubber, mixed rubber of natural rubber and synthetic rubber, Teflon (registered trademark), silicone rubber, and the like.

  The shape of the gasket portion is preferably a substantially cylindrical or substantially disc-shaped plug or piston having a plurality of ring-shaped convex portions. With such a shape, the frictional force is reduced when the gasket portion slides, and the portion where the gasket portion is in close contact with the cylindrical body wall is divided. An airtight state can be stably maintained.

  In each gasket part shown by FIGS. 6-7, although a substantially plane is illustrated as a shape of a pressure side surface and / or a discharge side surface, the pressure side surface and / or the discharge side surface of the gasket part The shape may be concave or convex.

  In the prefilled syringe (3) shown in FIGS. 6 to 7, the discharge port (a) 626a of the discharge unit (a) 626 and the discharge port (b) 616a of the discharge unit (b) 616 are attached to the clasps 627 and 617, respectively. However, the discharge part and the cylinder may be directly engaged without using a clasp, or the cylinder and the discharge part may be integrally formed. In the former case, as shown by the number 626b in FIGS. 6 to 7, the surface on the pressing side of the clasp is the most discharge side wall surface.

  Moreover, it does not specifically limit about the kind of content (a)-(b) in the prefilled syringe (3) shown by FIGS. 6-7, Specifically, it applies to the prefilled syringe mentioned later. Will be described in detail in the section “Contents”.

  In addition, in the prefilled syringe (3) shown in FIG. 7, when both the pressing side space (b) 713a and the intermediate space (b) 713b include the contents (b), the contents included in the respective spaces The thing may be the same or different.

  Although the shape of each bypass part in the prefilled syringe (3) shown in FIGS. 6 to 7 is not particularly limited, the bypass part of the prefilled syringe (3) is a space part due to the movement of the gasket part by the pressing operation as described above. There is no particular limitation as long as it can be conducted between the two. For example, a tubular structure formed inside or outside the cylindrical body, a groove formed on the cylindrical body wall, and the like can be given. Among these, it is preferable that the bypass portion has a groove shape in that the structure is simple, it is easy to create, and a failure is unlikely to occur.

  Further, in terms of easy formation, the bypass portion has a shape in which the groove width 34 ′ gradually decreases toward the outer periphery 31 of the cylinder, as indicated by reference numeral 34 in FIG. It is preferable. In addition, as shown by the numbers 34a and 34b in FIG. 3B, a plurality of grooves may be provided as the bypass portion. The groove width 34 ′ is not particularly limited as long as the groove width 34 ′ is large enough not to interfere with the conduction of the contents and small enough not to hinder the movement of the gasket portion. Further, the depth 34 ″ of the groove only needs to be formed deep enough to prevent the contents from being conducted.

  For example, in the plane perpendicular to the long axis direction of the cylinder, the width of the inner surface of the cylinder is larger than the width of the groove when compared with the width of projection by parallel rays from any direction. When measured along the inner circumference 31 ′ of the inner surface of the part, it is preferably 0.2 to 10 mm, more preferably 0.5 to 6 mm, and further preferably 1 to 4 mm.

  Ratio of groove width to the area of this bypass part (maximum cross-sectional area of the bypass part) when the area when the part where the bypass part of the cylindrical body is formed is perpendicular to the major axis direction (Maximum cross-sectional area of the bypass portion / groove width) is preferably 0.01 to 2 mm, more preferably 0.05 to 1 mm, and still more preferably 0.1 to 0.5 mm. The ratio (maximum cross-sectional area of the bypass portion / groove width) is the same as the value indicating the average groove depth when the groove as the bypass portion has the maximum cross-sectional area.

  The groove as the bypass part may be formed by inserting a cutting tool into the inner surface of the cylindrical body and cutting it, or after cutting the cylindrical part into the length and width of the groove, a shallow member is inserted by the depth of the groove. They may be formed by joining them. Or you may form a groove | channel using injection molding using a split type nest | insert. Alternatively, the groove may be formed by inflating to the outside by applying gas pressure to the inside of the cylinder or pressing a mold against the part in a state where the groove is heated and softened.

  In addition, when a bypass part such as a tubular structure or a groove is formed by using a polymer or an adhesive, the contents contained in the space where the bypass part is formed are in contact with the polymer or the adhesive. As a result, there may be a problem that the contents react with the polymer, the adhesive, or the like, or the characteristics change. In this case, if such contents are stored in a space portion where no bypass portion is formed in the space portion such as the pressure side spaces (b) 613 and 713a or the space portion (a) 623 in FIGS. The above problems can be avoided.

Further, the length (FIGS. 6 to 7: L ₁ , L ₁ ′) in the major axis direction of the bypass part (b ₁ ) and / or the bypass part (b ₂ ) is a space part in which the bypass part is formed. The length in the major axis direction (FIGS. 6 to 7: L ₂ , L ₂ ′) is shorter, and the thickness in the major axis direction of the gasket portion located on the pressing side of the bypass portion (FIGS. 6 to 7: L ₃ , preferably longer than L ₃ ′).

Also, the total thickness in the major axis direction of each gasket portion located on the pressing side of the bypass portion (FIG. 6: L ₃ + L ₄ , FIG. 7: L ₃ + L ₄ or L ₃ + L ₃ ′ + L ₄ ) or this Among these, the length in the major axis direction of the bypass portion is larger than the thickness in the major axis direction of one gasket portion (FIG. 6: L ₃ , L ₄ , 7: L ₃ , L ₃ ′, L ₄ ). 6 to 7: L ₁ and L ₁ ′) are preferably small. By comprising in this way, it can prevent that the contents flow backward from the space part located in the discharge side to the space part located in the press side.

  In addition, when the space portions are not in a conductive state, the contents are not exposed to the outside of the cylindrical body and are not discharged. Therefore, the contents can be freely stirred in the intermediate space. In the stirring operation, for example, the cylinder may be shaken by shaking, or vibration may be applied by an ultrasonic vibration device. Alternatively, by reverse operation to the pressing operation (operation to pull back the plunger portion from the discharge side to the pressing side), the contents are made to flow back one or more times from the space portion positioned on the discharge side to the space portion positioned on the pressing side. , Can stir the contents.

  As described above, the prefilled syringe (3) of the present invention has the bypass portion, so that the troublesome operation of opening and closing the discharge portion for degassing and preventing the content leakage is prevented when the contents are mixed. In addition, the stirring operation of the mixture can be performed safely.

  The volume of the space in which the contents are accommodated / filled is set according to the type and amount of the contents to be accommodated / filled, but is set larger than the amount of the contents. In the space remaining after filling and filling the space, an inert gas such as nitrogen gas or argon gas, or a gas (low reactivity gas) or liquid (low reactivity) with respect to the contents Reactive liquid) may be enclosed.

  In the prefilled syringe (3) which does not have the intermediate space (b) as shown in FIG. 6 in order to reliably prevent the contents contained in the cylinder from being exposed to the outside of the cylinder, Preferably, the part (b) contains a low-activity substance or an inert substance as the contents, and the discharge-side space part (b) contains an active substance as the contents.

  In order to further ensure the isolation between the contents, in the prefilled syringe (3) having a plurality of intermediate space portions (b) as shown in FIG. 7, at least one of the plurality of intermediate space portions. In the space portion, a low-active substance or an inert substance is contained as a content, and the intermediate space portion or the pressure side space portion located on both sides of the intermediate space portion containing the low-active substance or the inert material is used as a content. Preferably an active substance is included.

The content (a) contained in the space (a) is preferably a solid content such as a powder, more preferably a powder that is insoluble or hardly soluble in the content (b). is there.
Further, in the prefilled syringe (3) 800 as shown in FIG. 8, the space (a) has the following (A5) to (A7), and the content (a) 823 ′ has a pressing side space ( a) A bypass portion (a) 814b that is included in 823a and that enables electrical connection between the pressing side space portion (a) 823a and the discharge portion side space portion (a) 823b may be formed. In the case of such a configuration, the content (a) flows from the inner cylinder part 610 into the pressing side space part (a) 823a by the pressing operation of the plunger part 615. Further, the discharge side gasket portion (a) 822c moves to the discharge side, and the pressure side surface S _{1 ″ of the} discharge side gasket portion (a) 822a is the pressure side end portion S _{2 of the} bypass portion (a) 814b. When passing through ″, the pressing side space portion (a) 823a and the discharge side space portion (a) 823b are formed to be in a conductive state via the bypass portion (a) 814b. ing.

(A5) Discharge side gasket portion (a) 822c located between the pressure side gasket portion (a) 622a and the discharge portion (a) 626 in the cylindrical body (a) 621
(A6) Press side space (a) 823a defined by the press side gasket part (a) 622a and the discharge side gasket part (a) 822c in the cylindrical body (a) 621
(A7) In the cylindrical body (a) 621, the discharge portion side space portion (a) 823b defined by the discharge side gasket portion (a) 822c and the discharge portion (a) 626
Further, the prefilled syringe (3) of the present invention is provided with a discharge port (a discharge port (a) 626) (in order to prevent foreign matter from the outside of the cylindrical part (A) from entering the contents of the space (a). a) 626a may have a revolver type switching channel, a check valve, a filter, or the like.

  6-7, in order to prevent the content of the outer cylinder part (A) 620 from being discharged to the outside, a cap similar to the prefilled syringe (2) illustrated in FIGS. 4 and 5 is provided on the discharge part (a). Although it is attached to the discharge port (a), it should not be limited to this. For example, as shown in FIG. 8, a mechanism using a bypass portion 814b and a discharge side gasket portion (a) 822c similar to the bypass portion and gasket portion included in the inner cylinder (B) may be used.

  However, in that case, in the pressing process for mixing, the gasket portion on the outer cylinder side may move at an unexpected timing, and there is a possibility that the contents that are not sufficiently mixed are discharged to the outside. In order to prevent this, it is preferable to provide some stopper function such as making the movable resistance of the gasket portion on the outer cylinder side sufficiently larger than that of the other gasket portions.

  In addition, the volume of the space part (a) 623 of the outer cylinder can be freely adjusted by pushing and pulling the inner cylinder itself regardless of the pressing process on the inner cylinder side. Therefore, the space part (a) 623 of the outer cylinder does not need to have an empty volume corresponding to the pressing process, unlike the cylinder (A).

  Moreover, the discharge part (a) 626 may be much thicker than the aspect shown by FIGS. 6-7, and may be the magnitude | size about the internal diameter of the inner cylinder 610 substantially. In this case, there is almost no distinction between the discharge side space 613 ′ of the inner cylinder 610 and the discharge side space 623 of the outer cylinder 621, and the contents on the outer cylinder side are held across both spaces. An aspect may be sufficient.

Furthermore, in the example illustrated in FIG. 6, a cylindrical body having the same configuration as the prefilled syringe (1) illustrated in FIG. 1 is used as the inner cylindrical body (B), but is not limited thereto. Absent.
For example, you may employ | adopt the prefilled syringe (2) illustrated by FIG. 4 as an inner cylinder part (B). Moreover, you may employ | adopt the prefilled syringe (3) itself as an inner cylinder part (B). In this case, it is comprised from three cylinder parts as a whole.

  A prefilled syringe provided with a plurality of syringes for storing contents has been conventionally known, but its structure / mechanism (for example, a configuration in which a plurality of syringes are arranged in parallel) is complicated. In manufacturing a syringe, complicated molding is required. On the other hand, as above-mentioned, the prefilled syringe (3) of this invention can exhibit the following effects by having a structure and mechanism different from the conventional prefilled syringe.

(1) At the time of storage, each content can be stored and stored individually safely and securely without mixing a plurality of contents.
(2) At the time of use, it is not necessary to take out each content from the syringe, each content can be sufficiently mixed in the syringe, and further, the content can be discharged easily and smoothly with good reliability.

[Contents applied to prefilled syringe]
Kinds of contents contained in each space portion of the prefilled syringe or composite prefilled syringe of the present invention and combinations thereof are not particularly limited, but may be placed in a mixed state for a long time during storage. A combination of contents which is not preferable and is required to be mixed immediately before use is exemplified.

  Examples of combinations of contents include a medical composition for dental or surgical use that is used by mixing two or more kinds, a bioadhesive material, a curable composition, etc. used for the medical use. The adhesive composition is mentioned.

Hereinafter, a combination of compositions suitable as a medical adhesive composition for dental or surgical use will be described.
That is, an initiator and an adhesive composition using the initiator, having a good affinity for living tissue, and repairing adhesion of living tissue, such as adhesion repair of teeth and bone tissue, protection of soft tissue wounds or surgical treatment It is suitable for bonding and fixing.

  As such a composition, first, 100 parts by weight of at least one organoboron compound (A) selected from the group consisting of trialkylboron, alkoxyalkylboron, dialkylborane and partially oxidized trialkylboron, boiling point 50 A polymerization initiator composition comprising 5 to 40 parts by weight of an aprotic solvent (B) having a boiling point of 120 ° C. to 120 ° C. and 0.2 to 5 parts by weight of an alcohol (C) having a boiling point of 60 to 180 ° C. Illustrated. Secondly, it contains 30 to 100 parts by weight of the polymerizable monomer (a), 0 to 70 parts by weight of the (meth) acrylate polymer (b) and 1 to 20 parts by weight of the polymerization initiator composition (c). And the dental adhesive composition whose sum total of a polymerizable monomer (a) and a (meth) acrylate polymer (b) is 100 weight part is illustrated. According to this composition, an organoboron polymerization initiator composition excellent in safety against ignition, fluidity and polymerization activity can be obtained, and further, safety, operability, adhesion and economy can be obtained by using the composition. An excellent dental adhesive composition is obtained.

  The organoboron compound (A) used in the present composition is at least one organoboron compound selected from the group consisting of trialkylboron, alkoxyalkylboron, dialkylborane and partially oxidized trialkylboron. Species or two or more can be used together.

  Examples of the trialkyl boron include triethyl boron, tripropyl boron, triisopropyl boron, tributyl boron, tri-sec-butyl boron, triisobutyl boron, tripentyl boron, trihexyl boron, triheptyl boron, trioctyl boron, tricyclopentyl. Examples thereof include those having a linear, branched or cyclocyclic alkyl group having 2 to 8 carbon atoms, such as boron and tricyclohexyl boron. As described above, all three alkyl groups may be the same, or only two may be the same or different from three. In this case, for example, the above-described trialkylboron is present. These alkyl groups may be used in appropriate combination.

  Examples of the alkoxyalkylboron include monoalkoxydialkylboron such as butoxydibutylboron. As in this case, it is preferable that the alkyl part of the alkoxy group and the alkyl group are the same because the raw material is easily obtained, but it is not particularly limited. In addition, dialkoxy monoalkyl boron may be used. As the dialkylborane, for example, two alkyl groups such as dicyclohexylborane and diisoamylborane may be the same or different depending on the case. In addition, examples in which a boron atom forms a monocyclic structure or a bridge of a bicyclo structure, such as 9-borabicyclo [3.3.1] nonane, can be given.

  Examples of the partially oxidized trialkyl boron include the partial oxide of the trialkyl boron. Particularly preferred is partially oxidized tributyl boron. As the partially oxidized trialkyl boron, one obtained by adding 0.3 to 0.9 mol, more preferably 0.4 to 0.6 mol of oxygen to 1 mol of trialkyl boron is used.

  Among these organoboron compounds, particularly good results are obtained when tributyl boron or partially oxidized tributyl boron is used. The most preferred organoboron compound is partially oxidized tributyl boron. As described above, all three alkyl groups may be the same, or only two may be the same or different from three.

  As the aprotic solvent (B), a solvent having a boiling point of 50 ° C. to 120 ° C. at 1 atmosphere is preferably used. A more preferable boiling point is in the range of 60 ° C to 90 ° C. As the aprotic solvent (B), if the value falls below the lower limit of the above numerical range, the aprotic solvent (B) volatilizes and scatters during transportation and storage of the present polymerization initiator, and the blending ratio decreases and ignition occurs. It is not preferable because the effect of suppression is reduced, and if it exceeds the upper limit of the above numerical range, volatilization / scattering will be insufficient during use and remain in the cured composition, reducing the adhesive performance of the adhesive composition It is not preferable.

  As an aprotic solvent (B), there is no active hydrogen present in a hydroxy group or a mercapto group that reacts with the organic boron compound (A), and a uniform solution is formed with the organic boron compound (A). Preferred solvents are preferably used.

  Specific examples of the aprotic solvent (B) include, for example, hydrocarbons such as pentane, hexane, cyclohexane, heptane, benzene and toluene; halogenated hydrocarbons such as fluorobenzene, dichloroethane and so-called freon; diethyl ether, diisopropyl ether, Examples include ethers such as ethylene glycol dimethyl ether and tetrahydrofuran; ketones such as acetone, methyl ethyl ketone, and diethyl ketone; esters such as methyl acetate, ethyl acetate, and isopropyl acetate. Of these, alkanes, ethers and esters are preferred, and hexane, diisopropyl ether and ethyl acetate are particularly preferred. These aprotic solvents (B) may be used alone or in combination of two or more.

  The content of the aprotic solvent (B) in the present polymerization initiator composition needs to be 5 to 40 parts by weight, more preferably 10 to 30 parts by weight with respect to 100 parts by weight of the organoboron compound (A). The most preferred amount is 10 to 25 parts by weight. When the content of the aprotic solvent (B) is less than 5 parts by weight with respect to 100 parts by weight of the organoboron compound (A), a sufficient dilution effect cannot be obtained and an effect of suppressing heat generation (ignition) is obtained. I can't. Moreover, when content of aprotic solvent (B) exceeds 40 weight part with respect to 100 weight part of organoboron compounds (A), there exists a tendency for the polymerization ability of a polymerization initiator composition to fall.

  Surprisingly, the alcohol (C) in the initiator composition suppresses heat generation (ignition) without reducing the polymerization activity in the coexistence with the aprotic solvent (B) by adding a specific small amount. Is possible. As the alcohol (C), one having a boiling point of 60 ° C. to 180 ° C. at 1 atmosphere is used. A preferred boiling point is in the range of 60 to 120 ° C. When the alcohol (C) is below the lower limit of the above numerical range, the alcohol (C) volatilizes and scatters during transportation and storage of the polymerization initiator, and the blending ratio is reduced to reduce the effect of suppressing ignition. And when it exceeds the upper limit of the numerical range, the curing time of the adhesive composition becomes longer, which is not preferable because the adhesive performance is lowered.

  Specific examples of the alcohol (C) include, for example, methanol, ethanol, n-propanol or its isomer, n-butanol or its isomer, n-pentanol or its isomer, n-hexanol or its isomer, n- Peptanol or an isomer thereof may be mentioned. More preferred are alcohols having 4 or less carbon atoms, and among these, ethanol and n-propanol are particularly preferred. These alcohols (C) may be used alone or in combination of two or more.

  Content of alcohol (C) in this polymerization initiator composition needs to be 0.2-5 weight part with respect to 100 weight part of organoboron compounds (A), More preferably, it is 0.3-4. 5 parts by weight, most preferably 0.5-4 parts by weight. When the content of the alcohol (C) is less than 0.2 parts by weight with respect to 100 parts by weight of the organoboron compound (A), a sufficient effect of suppressing heat generation (ignition) cannot be obtained. Moreover, when content of alcohol (C) exceeds 5 weight part with respect to 100 weight part of organoboron compounds (A), there exists a tendency for the polymerization ability of a polymerization initiator composition to fall.

Furthermore, the dental adhesive composition using the said polymerization initiator composition is provided.
That is, according to the present composition, (a) the polymerizable monomer is preferably 30 to 100 parts by weight, more preferably 40 to 80 parts by weight, and (b) the (meth) acrylate polymer is 0 to 70 parts by weight. More preferably 10 to 60 parts by weight and (c) the polymerization initiator composition contains 1 to 20 parts by weight, more preferably 3 to 15 parts by weight, and the polymerizable monomers (a) and ( A dental or surgical adhesive composition in which the total of the (meth) acrylate polymer (b) is 100 parts by weight is provided. When the component (a) is below the lower limit of the numerical range, the operability of the composition is lowered, which is not preferable. Moreover, when the said (b) component exceeds the upper limit of the said numerical range, the operativity of a composition will fall and it is unpreferable. Furthermore, when the component (c) is below the lower limit of the numerical range, the curing time of the adhesive composition is undesirably long, and when the upper limit of the numerical range is exceeded, the curing time of the adhesive composition is excessively shortened, The operability is impaired, which is not preferable. The term “(meth) acrylate” means “acrylate and / or methacrylate”. In other cases (for example, “methyl (meth) acrylate” means “methyl acrylate and / or methyl methacrylate”). The same applies to This is an idiomatic expression in the art.

  In the present adhesive composition, as the polymerizable monomer (a), a known monofunctional monomer or polyfunctional monomer can be used without any limitation. (Meth) acrylate monomers are preferably used because of their relatively low irritation to the human body. Moreover, the polymerizable monomer which has an acidic group in a molecule | numerator is preferable as a component which gives the high adhesive force with respect to a tooth | gear especially. Therefore, a combination of (meth) acrylate and a polymerizable monomer having an acidic group is also preferably used.

  Examples of monofunctional (meth) acrylates include methyl (meth) acrylate, ethyl (meth) acrylate, propyl (meth) acrylate, butyl (meth) acrylate, hexyl (meth) acrylate, (meth) Alkyl (meth) acrylates such as 2-ethylhexyl acrylate, dodecyl (meth) acrylate, lauryl (meth) acrylate, cyclohexyl (meth) acrylate, benzyl (meth) acrylate, isobornyl (meth) acrylate; 2-hydroxyethyl (meth) acrylate, 2- or 3-hydroxypropyl (meth) acrylate, 4-hydroxybutyl (meth) acrylate, 5-hydroxypentyl (meth) acrylate, 6-hydroxyhexyl (meth) acrylate, 1, 2- or 1,3-dihydroxypro Hydroxyalkyl esters of (meth) acrylic acid such as rumono (meth) acrylate and erythritol mono (meth) acrylate; diethylene glycol mono (meth) acrylate, triethylene glycol mono (meth) acrylate, polyethylene glycol mono (meth) acrylate, polypropylene glycol Polyethylene glycol mono (meth) acrylates such as mono (meth) acrylate; ethylene glycol monomethyl ether (meth) acrylate, ethylene glycol monoethyl ether (meth) acrylate, diethylene glycol monomethyl ether (meth) acrylate, triethylene glycol monomethyl ether (meth) Acrylate, polyethylene glycol monomethyl ether (meth) acrylate, (Poly) glycol monoalkyl ether (meth) acrylates such as propylene glycol monoalkyl ether (meth) acrylate; fluoroalkyl esters of (meth) acrylic acid such as perfluorooctyl (meth) acrylate and hexafluorobutyl (meth) acrylate Silane compounds having a (meth) acryloxyalkyl group such as γ- (meth) acryloxypropyltrimethoxysilane, γ- (meth) acryloxypropyltri (trimethylsiloxy) silane; and tetrahydrofurfuryl (meth) acrylate (Meth) acrylates having a heterocyclic ring of

Examples of the polyfunctional (meth) acrylate include ethylene glycol di (meth) acrylate, propylene glycol di (meth) acrylate, butylene glycol di (meth) acrylate, neopentyl glycol di (meth) acrylate, and hexylene glycol. Poly (meth) acrylates of alkane polyols such as di (meth) acrylate, 2-hydroxypropyl di (meth) acrylate, trimethylolpropane tri (meth) acrylate, pentaerythritol tetra (meth) acrylate; diethylene glycol di (meth) acrylate, Triethylene glycol di (meth) acrylate, polyethylene glycol di (meth) acrylate, dipropylene glycol di (meth) acrylate, polypropylene glycol Di (meth) acrylate, dibutylene glycol di (meth) acrylate, polyoxyethylene alkane polyol poly (meth) acrylates such as dipentaerythritol hexa (meth) acrylate;
Following formula (1)

ここで、Ｒは水素原子またはメチル基であり、ｍおよびｎは同一もしくは異なり０〜１０の数であり、そしてＲ¹は

Here, R is a hydrogen atom or a methyl group, m and n are the same or different and have a number of 0 to 10, and R ¹ is

で表わされる脂肪族または芳香族のジ（メタ）アクリレート；
さらに、下記式（２）

An aliphatic or aromatic di (meth) acrylate represented by:
Further, the following formula (2)

ここで、Ｒは水素原子またはメチル基であり、ｎは０〜１０の数であり、そしてＲ¹は

Here, R is a hydrogen atom or a methyl group, n is a number from 0 to 10, and R ¹ is

で表わされる、分子内にヒドロキシル基を有する脂肪族または芳香族ジ（メタ）アクリレート；
および下記式（３）

An aliphatic or aromatic di (meth) acrylate having a hydroxyl group in the molecule represented by:
And the following formula (3)

ここで、Ｒは水素原子またはメチル基であり、そしてＲ¹は

Where R is a hydrogen atom or a methyl group, and R ¹ is

で表わされる分子中にウレタン結合を有する多官能（メタ）アクリレート
などを挙げることができる。

A polyfunctional (meth) acrylate having a urethane bond in the molecule represented by

  Among these, monofunctional (meth) acrylates include alkyl (meth) acrylates such as methyl (meth) acrylate and ethyl (meth) acrylate; 2-hydroxyethyl (meth) acrylate, 1,3- Hydroxyl-containing (meth) acrylates such as dihydroxypropyl mono (meth) acrylate and erythritol mono (meth) acrylate; ethylene glycol in the molecule such as triethylene glycol monomethyl ether (meth) acrylate and triethylene glycol mono (meth) acrylate A (meth) acrylate having a chain is particularly preferably used.

Examples of the polyfunctional (meth) acrylate include di (meth) acrylate having an ethylene glycol chain in the molecule such as triethylene glycol di (meth) acrylate and polyethylene glycol di (meth) acrylate, and 2-hydroxypropyl. Di (meth) acrylate,
The following formula (1) -a

（ここで、Ｒ、ｍおよびｎの定義は式（１）に同じである。）
で表わされる化合物、
下記式（２）−ａ

(Here, the definitions of R, m and n are the same as in formula (1).)
A compound represented by
Following formula (2) -a

（ここで、Ｒの定義は式（２）に同じである。）
で表わされる化合物、
下記式（３）−ａ

(Here, the definition of R is the same as in formula (2).)
A compound represented by
Following formula (3) -a

（ここで、Ｒの定義は式（３）に同じである。）
などが特に好ましく用いられる。これらは単独で、または２種類以上併用することができる。

(Here, the definition of R is the same as in formula (3).)
Etc. are particularly preferably used. These can be used alone or in combination of two or more.

Examples of the polymerizable monomer having an acidic group in the molecule include:
(Meth) acrylic acid and its anhydride, 1,4-di (meth) acryloxyethyl pyromellitic acid, 6- (meth) acryloxyethylnaphthalene-1,2,6-tricarboxylic acid, N- (meth) acryloyl -P-aminobenzoic acid, N- (meth) acryloyl-o-aminobenzoic acid, N- (meth) acryloyl-m-aminobenzoic acid, N- (meth) acryloyl-5-aminosalicylic acid, N- (meth) Acryloyl-4-aminosalicylic acid, 4- (meth) acryloxyethyl trimellitic acid and its anhydride, 4- (meth) acryloxybutyl trimellitic acid and its anhydride, 4- (meth) acryloxyhexyl trimellitic acid And its anhydride, 4- (meth) acryloxydecyl trimellitic acid and its anhydride, 2- (meth) acryloyl Xylbenzoic acid, 3- (meth) acryloyloxybenzoic acid, 4- (meth) acryloyloxybenzoic acid, β- (meth) acryloyloxyethyl hydrogen succinate, β- (meth) acryloyloxyethyl hydrogen maleate, a monomer containing a carboxylic acid group such as β- (meth) acryloyloxyethyl hydrogen phthalate, 11- (meth) acryloyloxy-1,1-undecanedicarboxylic acid, p-vinylbenzoic acid or an anhydride thereof;
Monomers containing phosphoric acid groups such as (2- (meth) acryloxyethyl) phosphoric acid, (2- (meth) acryloxyethylphenyl) phosphoric acid, 10- (meth) acryloxydecylphosphoric acid; and p- Mention may be made of monomers containing sulfonic acid groups such as styrenesulfonic acid and 2-acrylamido-2-methylpropanesulfonic acid.

  These acidic monomers can be used alone or in combination. The compounding amount of the polymerizable monomer containing an acidic group is preferably 2 to 20 parts by weight when the total polymerizable monomer (a) is 100 parts by weight.

  Examples of the (meth) acrylate polymer (b) contained in the adhesive composition include polymethyl (meth) acrylate, polyethyl (meth) acrylate, methyl (meth) acrylate / ethyl (meth) acrylate copolymer, methyl ( Non-crosslinkable polymers such as (meth) acrylate / butyl (meth) acrylate copolymer, methyl (meth) acrylate / styrene copolymer, methyl (meth) acrylate / ethylene glycol di (meth) acrylate copolymer, methyl (meth) And a crosslinkable polymer such as an acrylate / triethylene glycol di (meth) acrylate copolymer and a copolymer of methyl (meth) acrylate and a butadiene monomer. As the component (b), it is also possible to use inorganic particles obtained by coating a metal oxide or metal salt with these alkyl methacrylate polymers. Component (b) can also be used in combination with component (a) in advance. Particularly preferred is polymethyl (meth) acrylate, and the weight average molecular weight is preferably 10,000 to 1,000,000, more preferably 50,000 to 500,000, and even more preferably 100,000 to 350,000. The weight average molecular weight / number average molecular weight (Mw / Mn), which is an index of molecular weight distribution, is preferably 3.2 or less, more preferably 2.5 or less, and even more preferably 2.2 or less. is there. The particles are preferably spherical, and the particle diameter (measured with a laser diffraction scattering type particle size distribution analyzer LA-910 manufactured by HORIBA) is preferably 1 to 50 μm, more preferably 3 to 30 μm. More preferably, it is 5-20 micrometers. Outside of the above numerical range, etc., when mixed with a monomer, the viscosity rapidly increases and the pot life may be shortened, or it may be difficult to adjust the viscosity to be suitable for application. There is. In addition, the polymethyl methacrylate particle | grains which satisfy | fill the said conditions are obtained by the gamma ray irradiation of about 30-80 kGy to the pearl polymerization polymethylmethacrylate particle | grains of a weight average molecular weight 1 million-2 million.

An appropriate amount of a polymerization inhibitor such as inorganic and organic fillers; organic composite fillers; filler colorants; hydroquinones can be added to the adhesive composition as necessary.
Examples of inorganic fillers include metal oxide powders such as zirconium oxide, bismuth oxide, titanium oxide, zinc oxide, and aluminum oxide particles, metals such as calcium carbonate, bismuth carbonate, calcium phosphate, zirconium phosphate, and barium sulfate. Examples thereof include glass powders such as salt powder, silica glass, aluminum-containing glass, barium-containing glass, strontium-containing glass, and zirconium silicate glass, silver-releasing filler, and fluorine-releasing filler. These inorganic fillers can be used alone or in combination.

In order to obtain a strong bond between the inorganic filler and the resin, it is preferable to use an inorganic filler that has been subjected to a surface treatment such as silane treatment or polymer coating.
In order to improve the film thickness reduction and restoration effect of the adhesive composition, the average particle diameter of the particles is preferably in the range of 0.01 to 30 μm, and more preferably in the range of 0.05 to 25 μm. It is particularly preferable that

  It should be noted that the composition and blending of the dental adhesive and the polymerization initiator composition as described above are prescriptions, and mixing may cause a chemical reaction to produce a product different from the above. obtain. For example, an alcohol may react with a trialkyl boron that is an organic boron compound to produce an alkoxyalkyl boron.

  The adhesive composition is used for dentistry or surgery. In using this adhesive composition for dentistry, it is preferable to pre-treat the teeth. Examples of the pretreatment include an etching process of the adhesion surface with an acidic solution, a modification process of the adhesion surface with a primer, or an etching and modification process of the adhesion surface with a primer having etching ability. Examples of the acidic solution used for the etching treatment include a 5 to 60% by weight phosphoric acid aqueous solution and a 10% by weight citric acid and 3% by weight ferric chloride aqueous solution. Examples of the primer used for the modification treatment of the adhesive surface include an aqueous solution containing 20 to 50% by weight of 2-hydroxyethyl acrylate, 2-hydroxymethyl acrylate, and 1,3-dihydroxypropyl mono (meth) acrylate. Can do. In addition, as a primer having an etching ability used for the etching and modification treatment of the adhesive surface, for example, an organic acid (a concept including a monomer having an acidic group) and a decalcified tooth are modified, and the tooth An aqueous solution containing a component that promotes diffusion of the adhesive composition is preferably used. Examples of the component that promotes diffusion of the adhesive composition into the tooth include hydroxyl group-containing monomers such as alkylene glycol, polyalkylene glycol, 2-hydroxyethyl (meth) acrylate, and 1,3-dihydroxypropyl mono (meth) acrylate. Or a polyethylene glycol (meth) acrylate etc. can be mentioned.

  The composition (A) containing the organoboron compound is improved in stability by the aprotic solvent (B) or the alcohol (C), but still has high reaction activity, so an adhesive or the like is used. It is preferable to avoid storing the composition in the space where the bypass portion is disposed. Or it is preferable to accommodate in the intermediate | middle space part of the inner side pinched | interposed into the space part from both sides rather than the discharge side space part with high possibility of touching external air. In addition, the composition containing the (meth) acrylate polymer (b) is not insoluble in the polymerizable monomer (a) or the like, but the viscosity is remarkably increased, and the content with the increased viscosity is bypassed. It may be difficult to bypass the section. Therefore, in the case of the prefilled syringe (1), it is preferable to store in the discharge side space portion, and in the case of the prefilled syringe (3), the space portion (a).

  In the prefilled syringes (1) to (3), the plunger portion is pressed during transportation (prefilled syringe (1), (3)) and the breakable ampule (prefilled syringe (2) )) And the like, the contents may be mixed with each other or leakage from the discharge part may occur. In order to prevent such a situation, it is preferable to take measures such as sealing the discharge side or fixing the plunger portion with a fastener.

  According to the present invention, it is suitable for various uses such as medical applications. (1) When storing, each content can be stored and stored individually safely and reliably. (2) When using, each content is sufficiently stored in the syringe. Furthermore, it is possible to provide a prefilled syringe or a composite prefilled syringe that can be easily and smoothly discharged with good reliability.

10: Prefilled syringe (1)
11: cylinder 11a: pressure side 11b of cylinder: discharge side 12a of cylinder: pressure side gasket part 12b, 12b ': intermediate gasket part 12c: discharge side gasket part 13a: pressure side space part 13b, 13b': intermediate Space part 13 ': Discharge side space part 14a: Bypass part (a)
14a ': Bypass part (a')
14b: Bypass section (b)
15: Plunger portion 16: Discharge portion 16a: Discharge port 16b: Outmost discharge side wall surface 17: Clasp 18: Discharged contents 31: Tube outer peripheral surface 31 ': Inner periphery of the inner surface of the cylinder 33: Space portion 34 ': Groove width 34': Groove depth 34, 34a, 34b: Groove-shaped bypass section 40: Prefilled syringe (2)
41: cylinder 41a: cylinder pressing side 41b: cylinder discharge side 41 ': cylinder part 42a: gasket part 42b: filter 42c: leakage prevention cap 43: cylinder interior 43a, 43b: Easily destructible ampules 43a 'and 43b' including contents: fractured easily destructible ampules 43ab: contents leaked from fractured easily destructible ampules 45: plunger part 46: discharge part 47: clasp 52b, 52b ': Filter 58: Spaces 58a, 58a' defined by the filter and the discharge part: Contents (powder)
600: Prefilled syringe (3)
610: Inner cylinder (B)
611: cylinder (b)
611a: the pressing side 611b of the cylinder (b): the discharge side 612a of the cylinder (b): the pressing gasket part (b)
612c: Discharge side gasket part (b)
613: Pressing side space (b)
613 ′: discharge side space (b)
614a: Bypass section (b ₁ )
614b: Bypass section (b ₂ )
615: Plunger part 616: Discharge part (b)
616a: Discharge port (b)
616b: most discharge side wall surface (b)
617, 627: clasp 620: outer cylinder (A)
621: Tube (a)
621a: Pressing side 621b of cylinder (a): Discharge side 622a of cylinder (a): Pressing gasket part (a)
622b: Leakage prevention cap 623: Space (a)
623 ′: contents (a)
626: discharge part (a)
626a: discharge port (a)
626b: most discharge side wall surface (a)
700: Prefilled syringe (3)
712a: Pressing gasket part (b)
712b: Intermediate gasket part (b)
712c: Discharge side gasket part (b)
713a: Pressing side space (b)
713b: intermediate space (b)
713 ′: discharge side space (b)
800: Prefilled syringe (3)
822c: Discharge side gasket part (a)
823a: Pressing side space (a)
823b: discharge side space (a)
814b: Bypass section (a)
S ₁ , S ₁ ′, S _{1 ″} : Gasket pressing side surfaces S ₂ , S ₂ ′, S _{2 ″} : Bypass portion pressing side ends L ₁ , L ₁ ′: Bypass portion major axis direction L ₂ , L ₂ ′: lengths L ₃ , L ₃ ′, L ₄ in the major axis direction of the space where the bypass portion is formed: thickness in the major axis direction of the gasket portion

Claims (15)

The following (1) to (9) are provided,
In at least one intermediate space portion, a bypass portion (a) for allowing conduction between the pressing side space portion and the intermediate space portion is formed,
In the discharge side space portion, a prefilled syringe in which a bypass portion (b) for enabling conduction between the intermediate space portion and the discharge side space portion is formed,
By pressing the plunger,
When the intermediate gasket portion located on the pressing side from the bypass portion (a) moves to the discharge side, and the pressing-side surface of the intermediate gasket portion passes the pressing-side end portion of the bypass portion (a). , The pressure side space and the intermediate space through the bypass part (a) is in a conductive state,
When the discharge-side gasket portion moves to the discharge side and the pressing-side surface of the discharge-side gasket portion passes the pressing-side end portion of the bypass portion (b), an intermediate space is provided via the bypass portion (b). And the discharge side space are in a conductive state,
Furthermore, the prefilled syringe is formed so that the contents flowing into the discharge side space can be discharged to the outside of the cylindrical body through the discharge.
(1) Cylindrical body (2) provided with a discharge part having the most discharge side wall surface located on the most discharge side and a discharge port for discharging contents The plunger part (3) inserted into the cylinder In the body, the pressure side gasket part (4) located on the discharge side from the plunger part In the cylinder, the discharge side gasket part (5) located between the pressure side gasket part and the discharge part In the cylinder, the pressure side At least one intermediate gasket portion (6) located between the gasket portion and the discharge side gasket portion (6) in the cylinder, and a pressing side space portion (7) defined by the pressing side gasket portion and the intermediate gasket portion, Discharge side space part (8) defined by discharge side gasket part and discharge part Intermediate space part (9) Press side space part and / or intermediate space defined by intermediate gasket part and discharge side gasket part in cylinder Contents included in the department A bypass portion (a) having a plurality of intermediate space portions and enabling conduction between the discharge-side intermediate space portion and the pressure-side intermediate space portion in at least one of the plurality of intermediate space portions; ′) Is formed,
By pressing the plunger,
The intermediate gasket portion located on the pressure side of the intermediate space portion on the discharge side moves to the discharge side, and the surface on the pressure side of the intermediate gasket portion is the end portion on the pressure side of the bypass portion (a ′) of the intermediate space portion. The discharge-side intermediate space portion and the pressure-side intermediate space portion are formed in a conductive state via the bypass portion (a ′) when passing through the bypass portion (a ′). A prefilled syringe according to 1.   The length in the major axis direction of the bypass portion is shorter than the length in the major axis direction of the space portion in which the bypass portion is formed, and in the major axis direction of the gasket portion located on the pressing side of the bypass portion. The prefilled syringe according to claim 1 or 2, wherein the prefilled syringe is longer than the thickness.   The prefilled syringe according to any one of claims 1 to 3, wherein the bypass portion has a groove shape. Having one intermediate space part, the intermediate space part contains a low-active substance or an inert substance as contents, and the pressing side space and the discharge side space part contain active substances as contents,
It has a plurality of intermediate space portions, and at least one of the plurality of intermediate space portions includes a low activity substance or an inert substance as a content, and includes the low activity substance or the inert substance. The prefilled syringe according to any one of claims 1 to 4, wherein an active substance is contained as a content in the intermediate space part or the pressing side space part located on both sides of the intermediate space part. A cylinder having a discharge part for discharging contents, a gasket part that can be slid in a liquid-tight or air-tight manner in the longitudinal direction of the cylinder part, and a plunger part for pressing the gasket part A prefilled syringe having
The cylindrical body is made of a flexible material, and has an easily destructible ampule in which the contents are enclosed,
When the tubular part is bent, the easily breakable ampoule breaks without breaking the tubular part, and the contents can leak from the broken easily breakable ampoule into the tubular part. The prefilled syringe is formed so that it can be discharged from the discharge portion to the outside of the cylindrical body by the pressing operation.   The prefilled syringe according to claim 6, further comprising a solid content inside the cylindrical body.   A filter for preventing the breakable pieces of the easily destructible ampule from being discharged is installed in the cylinder on the discharge portion side of the easily destructible ampule, and in a space defined by the filter and the discharge portion. The prefilled syringe according to claim 6 or 7, wherein a solid content is contained.   The prefilled syringe according to any one of claims 6 to 8, wherein a filter for preventing the breakable pieces of the easily destructible ampule from discharging covers the easily destructible ampule.   The prefilled syringe according to any one of claims 6 to 9, wherein a material of the easily destructible ampule is glass.   The prefilled syringe according to claim 10, wherein the easily breakable ampoule is made of breakable glass. An outer cylinder part (A) having the following (A1) to (A4) and an inner cylinder part (B) having the following (B1) to (B7),
A pressing side gasket part (a) and the inner cylinder part (B) are sequentially inserted into the cylindrical body (a) toward the discharging part (a), and the discharging part (b) is connected to the pressing side gasket part (a). )
In the discharge-side space portion (b), a composite prefilled syringe in which a bypass portion (b ₂ ) for enabling electrical connection between the pressing-side space portion (b) and the discharge-side space portion (b) is formed. ,
By pressing the plunger,
When the discharge-side gasket portion (b) moves to the discharge side and the pressing-side surface of the discharge-side gasket portion (b) passes through the pressing-side end portion of the bypass portion (b ₂ ), the bypass portion ( b ₂ ), the discharge-side space portion (b) and the pressing-side space portion (b) become conductive,
The content (b) flows into the discharge side space (b), and further, the content (b) flows into the space (a) via the discharge portion (b), and the content (b). In addition, the composite prefilled syringe is formed so that the content (a) can be discharged to the outside of the outer tube portion through the discharge portion (a).
(A1) Cylindrical body (a) provided with a discharge part (a) having the most discharge side wall surface (a) located on the most discharge side and the discharge port (a) for discharging the contents
(A2) Press side gasket part (a) located on the pressing side of the discharge part (a) in the cylindrical body (a)
(A3) In the cylindrical body (a), a space part (a) defined by the pressing side gasket part (a) and the discharge part (a)
(A4) Contents (a) contained in space (a)
(B1) Cylindrical body (b) having a discharge part (b) having the most discharge side wall surface (b) located on the most discharge side and the discharge port (b) for discharging the contents
(B2) Plunger part (b) inserted into the cylinder (b)
(B3) Press side gasket portion (b) located on the discharge side of the plunger portion (b) in the cylindrical body (b)
(B4) Discharge side gasket portion (b) located between the pressing side gasket portion (b) and the discharge portion (b) in the cylindrical body (b)
(B5) Press side space (b) defined by the press side gasket part (b) and the discharge side gasket part (b) in the cylindrical body (b).
(B6) The discharge side space (b) defined by the discharge side gasket part (b) and the discharge part (b) in the cylindrical body (b).
(B7) Contents (b) contained in the pressing side space (b) An outer cylinder part (A) having the following (A1) to (A4) and an inner cylinder part (B) having the following (B1) to (B9),
A pressing side gasket part (a) and the inner cylinder part (B) are sequentially inserted into the cylindrical body (a) toward the discharging part (a), and the discharging part (b) is connected to the pressing side gasket part (a). )
In at least one intermediate space portion (b), a bypass portion (b ₁ ) for enabling conduction between the pressing side space portion (b) and the intermediate space portion (b),
In the discharge-side space portion (b), a composite prefilled syringe in which a bypass portion (b ₂ ) for enabling electrical connection between the intermediate space portion (b) and the discharge-side space portion (b) is formed. ,
By pressing the plunger part (b),
The intermediate gasket part (b) located on the pressing side from the bypass part (b ₁ ) moves to the discharge side, and the pressing side surface of the intermediate gasket part (b) is the pressing side end of the bypass part (b ₁ ). When passing through the part, the intermediate space part (b) and the pressing side space part (b) are in a conductive state through the bypass part (b ₁ ),
When the discharge-side gasket portion (b) moves to the discharge side and the pressing-side surface of the discharge-side gasket portion (b) passes through the pressing-side end portion of the bypass portion (b ₂ ), the bypass portion ( b ₂ ), the intermediate space portion (b) and the discharge side space portion (b) are in a conductive state,
The content (b) flows into the discharge side space (b), and further, the content (b) flows into the space (a) via the discharge portion (b), and the content (b). In addition, the composite prefilled syringe is formed so that the content (a) can be discharged to the outside of the outer tube portion through the discharge portion (a).
(A1) Cylindrical body (a) provided with a discharge part (a) having the most discharge side wall surface (a) located on the most discharge side and a discharge port for discharging the contents
(A2) Press side gasket part (a) located on the pressing side of the discharge part (a) in the cylindrical body (a)
(A3) In the cylindrical body (a), a space part (a) defined by the pressing side gasket part (a) and the discharge part (a)
(A4) Contents (a) contained in space (a)
(B1) Cylindrical body (b) provided with a discharge part (b) having the most discharge side wall surface (b) located on the most discharge side and a discharge port for discharging the contents
(B2) Plunger part (b) inserted into the cylinder (b)
(B3) In the cylinder (b), the pressing side gasket portion (b) located on the discharge side from the plunger portion (b)
(B4) Discharge side gasket portion (b) located between the pressure side gasket portion and the discharge portion in the cylindrical body (b)
(B5) Intermediate gasket portion (b) located between the pressing side gasket portion (b) and the discharge side gasket portion (b) in the cylindrical body (b).
(B6) In the cylindrical body (b), the pressure side space (b) defined by the pressure side gasket part (b) and the intermediate gasket part (b)
(B7) The discharge side space (b) defined by the discharge side gasket portion (b) and the discharge portion (b) in the cylindrical body (b).
(B8) An intermediate space portion (b) defined by the discharge side gasket portion (b) and the intermediate gasket portion (b) in the cylindrical body (b).
(B9) Contents (b) contained in the pressure side space (b) and / or the intermediate space (b) It has a plurality of intermediate space portions (b), and at least one of the plurality of intermediate space portions (b) includes a discharge-side intermediate space portion (b) and a pressure-side intermediate space portion (b). And a bypass portion (b ₃ ) for enabling conduction is formed,
By pressing the plunger,
The intermediate gasket portion (b) located on the pressing side of the intermediate space portion (b) on the discharge side moves to the discharge side, and the surface on the pressing side of the intermediate gasket portion is the bypass portion (b ₃ ) When passing through the pressing-side end, the discharge-side intermediate space (b) and the pressing-side intermediate space (b) are brought into conduction via the bypass portion (b ₃ ). The composite prefilled syringe according to claim 12 or 13, wherein the composite prefilled syringe is formed as described above. The space (a) has the following (A5) to (A7),
The content (a) is included in the following pressing side space (a),
A bypass portion (a) is formed to enable electrical connection between the pressing side space (a) and the discharge side space (a).
When the discharge-side gasket portion (a) moves to the discharge side and the pressing-side surface of the discharge-side gasket portion (a) passes through the pressing-side end portion of the bypass portion (a), the pressing-side space portion ( The a) and the discharge side space part (a) are formed so as to be in a conductive state via the bypass part (a). The composite prefilled syringe according to item.
(A5) Discharge side gasket portion (a) located between the pressing side gasket portion (a) and the discharge portion (a) in the cylindrical body (a)
(A6) In the cylindrical body (a), the pressure side space (a) defined by the pressure side gasket part (a) and the discharge side gasket part (a)
(A7) In the cylindrical body (a), the discharge part side space part (a) defined by the discharge side gasket part (a) and the discharge part (a)

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