JP2011045473A5 - - Google Patents
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- JP2011045473A5 JP2011045473A5 JP2009195275A JP2009195275A JP2011045473A5 JP 2011045473 A5 JP2011045473 A5 JP 2011045473A5 JP 2009195275 A JP2009195275 A JP 2009195275A JP 2009195275 A JP2009195275 A JP 2009195275A JP 2011045473 A5 JP2011045473 A5 JP 2011045473A5
- Authority
- JP
- Japan
- Prior art keywords
- calcium
- mixture
- powder
- group
- phosphoric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 14
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 11
- 239000000843 powder Substances 0.000 claims 7
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 5
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium monoxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 4
- 238000001816 cooling Methods 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- JHLNERQLKQQLRZ-UHFFFAOYSA-N Calcium silicate Chemical compound [Ca+2].[Ca+2].[O-][Si]([O-])([O-])[O-] JHLNERQLKQQLRZ-UHFFFAOYSA-N 0.000 claims 3
- 108010010803 Gelatin Proteins 0.000 claims 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L cacl2 Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 3
- 239000001110 calcium chloride Substances 0.000 claims 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims 3
- 159000000007 calcium salts Chemical class 0.000 claims 3
- 239000000378 calcium silicate Substances 0.000 claims 3
- 229910052918 calcium silicate Inorganic materials 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 239000008273 gelatin Substances 0.000 claims 3
- 229920000159 gelatin Polymers 0.000 claims 3
- 235000019322 gelatine Nutrition 0.000 claims 3
- 235000011852 gelatine desserts Nutrition 0.000 claims 3
- 238000000227 grinding Methods 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 3
- VSGNNIFQASZAOI-UHFFFAOYSA-L Calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L Calcium hydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims 2
- 239000002639 bone cement Substances 0.000 claims 2
- 239000001639 calcium acetate Substances 0.000 claims 2
- 229960005147 calcium acetate Drugs 0.000 claims 2
- 235000011092 calcium acetate Nutrition 0.000 claims 2
- 239000000920 calcium hydroxide Substances 0.000 claims 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims 2
- 239000000292 calcium oxide Substances 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 150000003377 silicon compounds Chemical class 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 238000003980 solgel method Methods 0.000 claims 2
- QORWJWZARLRLPR-UHFFFAOYSA-H Tricalcium phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L phosphate Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims 1
- 229940085991 phosphate ion Drugs 0.000 claims 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- JXJTWJYTKGINRZ-UHFFFAOYSA-J silicon(4+);tetraacetate Chemical compound [Si+4].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O JXJTWJYTKGINRZ-UHFFFAOYSA-J 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- YZVRVDPMGYFCGL-UHFFFAOYSA-N triacetyloxysilyl acetate Chemical compound CC(=O)O[Si](OC(C)=O)(OC(C)=O)OC(C)=O YZVRVDPMGYFCGL-UHFFFAOYSA-N 0.000 claims 1
Claims (10)
（ａ）カルシウム塩をケイ素化合物と混合する工程であって、前記カルシウム塩が、酸化カルシウム、水酸化カルシウム、酢酸カルシウム、および塩化カルシウムからなる群より選択され、前記ケイ素化合物が、二酸化ケイ素および四酢酸ケイ素からなる群より選択されるものである工程；
（ｂ）工程（ａ）の混合物をゾルゲル法で処理する工程；
（ｃ）工程（ｂ）の混合物を加熱する工程；
（ｄ）工程（ｃ）の混合物に、塑性を増すために、総質量に対して２〜３０質量％の範囲でゼラチンを添加する工程；
（ｅ）工程（ｄ）の混合物を粉末に粉砕する工程；および
（ｆ）前記粉末を水またはリン酸溶液に添加する工程、
を有してなる方法。 A method for producing a calcium silicate bone cement containing a polymer,
(A) a step of mixing a calcium salt with a silicon compound , wherein the calcium salt is selected from the group consisting of calcium oxide, calcium hydroxide, calcium acetate and calcium chloride; A step selected from the group consisting of silicon acetate ;
(B) treating the mixture with a sol-gel method step (a);
(C) heating the mixture of step (b);
(D) the mixture of step (c), in order to increase the plasticity, adding gelatin in the range of 2 to 30% by weight relative to the total weight;
(E) a step of grinding the mixture of step (d) in powder; and (f) adding pre-Symbol powder in water or phosphoric acid solution,
A method comprising :
（ｉ）前記工程（ａ）からの混合物を、エタノールおよび硝酸からなる群より選択される希釈溶媒と１〜１２時間に亘り混合し、
（ｉｉ）前記混合物を１〜７日間に亘り２０〜１００℃の温度に配置し、
（ｉｉｉ）前記混合物を−４０〜１５０℃で乾燥させる、
各工程を含むことを特徴とする請求項１または２記載の方法。 The sol-gel method is
(I) mixing the mixture from step (a) with a diluent solvent selected from the group consisting of ethanol and nitric acid for 1-12 hours;
(Ii) placing the mixture at a temperature of 20-100 ° C. for 1-7 days;
(Iii) drying the mixture at −40 to 150 ° C .;
The method according to claim 1 or 2 , comprising each step.
（ｉ）前記工程（ｂ）からの混合物を１〜４０℃／分の速度で７００〜１３００℃に加熱し、
（ｉｉ）前記混合物を７００〜１３００℃の定温範囲に維持し、
（ｉｉｉ）前記混合物を、空冷、水冷または高速冷却技法によって室温まで冷却して、ケイ酸カルシウム粉末を得る、
各工程を含むことを特徴とする請求項１から３いずれか１項記載の方法。 The heating step is
(I) heating the mixture from step (b) to 700-1300 ° C at a rate of 1-40 ° C / min;
(Ii) maintaining the mixture in a constant temperature range of 700-1300 ° C;
(Iii) cooling the mixture to room temperature by air cooling, water cooling or fast cooling techniques to obtain a calcium silicate powder;
3 any one method according to claim 1, characterized in that it comprises the steps.
（ｉ）前記ゼラチンを含有する前記ケイ酸カルシウム粉末をアルコールと混合し、
（ｉｉ）前記粉末をボールミル粉砕機で０．５〜３日間に亘り粉砕し、
（ｉｉｉ）前記粉末を−４０〜６０℃で乾燥させる、
各工程を含むことを特徴とする請求項１から４いずれか１項記載の方法。 The grinding step
(I) mixing the calcium silicate powder containing the gelatin with alcohol;
(Ii) grinding the powder with a ball mill for 0.5 to 3 days;
(Iii) drying the powder at −40-60 ° C.,
4 any one method according to claim 1, characterized in that it comprises the steps.
（ａ）酸化カルシウム、水酸化カルシウム、酢酸カルシウム、および塩化カルシウムからなる群より選択されるカルシウム塩、
（ｂ）二酸化ケイ素および四酢酸ケイ素からなる群より選択されるケイ素化合物、
（ｃ）総質量に対して２〜３０質量％の範囲のゼラチン、および
（ｄ）薬理学的に許容される溶液、
を含むことを特徴とする組成物。 A composition for a calcium phosphate bone cement containing a polymer comprising:
(A) a calcium salt selected from the group consisting of calcium oxide, calcium hydroxide, calcium acetate, and calcium chloride ;
(B) a silicon compound selected from the group consisting of silicon dioxide and silicon tetraacetate ,
(C) gelatin in the range of 2-30% by weight relative to the total weight , and (d) a pharmacologically acceptable solution,
Composition characterized in including things.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009195275A JP5210266B2 (en) | 2009-08-26 | 2009-08-26 | Calcium silicate composite cement and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009195275A JP5210266B2 (en) | 2009-08-26 | 2009-08-26 | Calcium silicate composite cement and preparation method thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011045473A JP2011045473A (en) | 2011-03-10 |
| JP2011045473A5 true JP2011045473A5 (en) | 2012-01-26 |
| JP5210266B2 JP5210266B2 (en) | 2013-06-12 |
Family
ID=43832413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009195275A Active JP5210266B2 (en) | 2009-08-26 | 2009-08-26 | Calcium silicate composite cement and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5210266B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6432983B2 (en) * | 2015-03-31 | 2018-12-05 | 株式会社松風 | Medical and dental curable composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07112023A (en) * | 1993-10-20 | 1995-05-02 | Matsumoto Shika Univ | Osteogenesis material |
| US20020037258A1 (en) * | 1999-08-05 | 2002-03-28 | Gregory P. Dodd | Dental composition for the mineral occlusion of dentinal tubules in sensitive teeth |
| ATE295744T1 (en) * | 2002-07-11 | 2005-06-15 | Biomet Deutschland Gmbh | METHOD FOR PRODUCING POROUS CALCIUM PHOSPHATE CHIPS AND GRANULES FROM GELATIN PROCESSING |
| GB0717516D0 (en) * | 2007-09-07 | 2007-10-17 | Imp Innovations Ltd | Bioactive nanocomposite material |
-
2009
- 2009-08-26 JP JP2009195275A patent/JP5210266B2/en active Active
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