JP2011036416A - Method for evaluation of biological cell function, measuring instrument, computer, computer program, recording medium, and cellular phone - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for evaluating a biological cell function which simply evaluates a pathosis simply from the condition of a patient who has not become ill yet. <P>SOLUTION: The method for evaluation is characterized in that: the pulse of the patient is measured; the temperature of the patient is measured at the same time when with the pulse is measured; the value given by dividing the pulse by the temperature is obtained; and the pathosis is evaluated from the condition of the patient who has not become ill yet on the basis of the value. The patient measures by himself or herself the pulse and the temperature using a measuring instrument, detects myocardial infarction and/or cerebral infarction which are ischemic change in the patient's body and infection and/or an autoimmune disease which are inflammatory reaction in the patient's body, and transmits alarm information to the patient. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a biological cell function evaluation method for simply evaluating a pathological state from a non-disease state in a subject.

Human beings and other organisms start with a single cell, increase the number of cells to become an organization, and grow as a living individual. Cells, which are the basis of biological activities, carry out various biochemical reactions using nutrients (carbohydrates, lipids, proteins, vitamins, minerals, etc.) supplied from the outside.
Carbohydrates and proteins are high molecular compounds, and in order to decompose (digest) and absorb them, unique enzyme proteins are required. This enzyme protein may require minerals such as iron and magnesium, and often requires vitamins as an auxiliary role.

  Carbohydrates are broken down into glucose by amylase. This glucose is finally converted from glucose into ATP, which is an energy storage compound, by intracellular substrates and mitochondria. This ATP is used for various cellular activities, but part of it is an energy source for protein degradation to amino acids and protein synthesis that matches amino acids with the human body. Newly synthesized proteins are used for enzymes, cellular components, muscles, skin, bones, etc.

Lipids are also used to form cell membranes. The inside and outside of the cell are partitioned by the lipid bilayer membrane, and the cell as a closed space is constructed. Proteins are incorporated between the lipid bilayers, and the functions of cell membranes such as mass transport and information transmission are enhanced.
Life activities are carried out on the basis of cells, and the integrated body of tissues and living bodies performs activities every day. Based on substances taken from outside the body, metabolites increase in the blood in the process of metabolizing various nutrients in cells of each organ. Metabolites are processed in organs such as the liver and excreted as waste products in the liver and kidneys.

  When living tissue activity is normal, the concentration of metabolites in the blood is within the reference range. Furthermore, with the aging of cells, enzymes in the cytoplasm from old cells that have been destroyed during cell remodeling are always released into the blood in a certain amount. By measuring the concentration of chemical substances in the blood, enzyme activity of enzyme proteins, and the like, the state of biological activity can be grasped. In order to maintain the life of living cells, an automatic regulation function called homeostasis works, and the concentration and enzyme activity of each biochemical substance are adjusted to a certain reference range.

  Blood tests and the like performed at medical sites are performed to detect such changes in biochemical reactions. Furthermore, when changes in the organ level occur, an attempt is made to capture changes in the living body by using an electrocardiogram, an X-ray photograph, CT, MRI or PET. By combining various tests, efforts are made to grasp the status of abnormal situations that have occurred in the living body and to investigate the cause and lead to treatment. Modern medicine has been developed based on this methodology.

However, in some cases, these examinations can be performed at home, but in most cases they are basically limited to medical facilities.
Currently, there are contradictions in various medical systems in Japan, and medical collapse has become serious. Hospital closures are steadily increasing due to a shortage of doctors. While medical costs have soared, an increasing number of people are unable to visit medical institutions due to the economic recession. In the future, as the aging society expands, the collapse of the medical field entails the danger of reducing the quality of medical care.

In addition, hypertension, diabetes, hyperlipidemia, etc., which have been called adult diseases and lifestyle-related diseases for a long time, have continued to increase. Since last year, the aim is to change the public awareness with the catchphrase of metabolic syndrome. During this time, more than 10 years have passed, but the incidence of cerebral infarction and myocardial infarction is still increasing.
After cerebral infarction and myocardial infarction have developed, it is fundamental to visit hospitals of a certain scale, including emergency hospitals. At this stage, it is often the case that a large amount of medical expenses are generated in a short period of time compared to the medical expenses until then. In order to avoid such a situation, medical examinations are conducted in advance, but it is not an approach that can cope with changes in the acute phase.

In this situation, it is necessary to establish a method that can detect signs of abnormalities in the simplest possible way just before any severe acute state is reached.
Therefore, conventionally, a measuring instrument is inserted into the ear, and the light obtained by irradiating the skin of the ear hole with light having a different wavelength is detected and processed to measure a biological signal such as pulse, body temperature, respiratory rate, etc. And a method have been proposed in US Pat.

JP 2004-329928 A

However, the above-described conventional example of Patent Document 1 does not simply evaluate the pathological state from the non-disease state in the subject.
Then, an object of this invention is to provide the evaluation method of the biological cell function which evaluates a pathological state simply from the non-disease state in a test subject.

  The biological cell function evaluation method of the present invention for solving the above problems is to measure a subject's pulse, measure the subject's body temperature simultaneously with the pulse, determine a value obtained by dividing the pulse by the body temperature, The morbid state is evaluated from the non-disease state in the subject by the value.

  According to the present invention, a morbid state is easily evaluated from an unaffected state in a subject.

It is a time-dependent change figure of the test subject's pulse in embodiment of this invention. It is a time-dependent change figure of the test subject's body temperature in embodiment of this invention. It is a time-dependent change figure of the value which remove | divided the pulse of the test subject in embodiment of this invention by the body temperature. It is a correlation figure of the value which remove | divided the pulse of the test subject in embodiment of this invention by body temperature, and body temperature. It is a block diagram of embodiment of this invention.

Embodiments of the present invention will be described below with reference to the accompanying drawings.
In the case of a test by a subject before performing a test at a medical institution, it is necessary to extract information from a living body without using special test equipment and test technology. In a method of obtaining biological information without visiting a medical institution, vital signs such as blood pressure correspond to the biological information, and vital signs provide basic information such as vital signs among the biological information.

  When a human performs daily activities, the living body transmits the first biological information from the cranial nerve to the whole body, and each organ performs its own function while receiving the information. For example, information from the cranial nerves is sent to the heart, and it becomes the heartbeat to produce blood flow. The vital sign associated with the heartbeat is “heart rate”, and in the periphery, it becomes “pulse” as the arterial beat. Furthermore, this blood flow from the heart creates pressure on the arterial wall and is measured in the form of “blood pressure”.

In addition, the activity of taking in oxygen necessary for the vital activity of cells is performed by respiration. The first organ of this breath is the lung, and the vital sign associated with the lung is "respiration rate".
Nutrients such as glucose transported to each organ and cell along the bloodstream are burnt (metabolized) using oxygen transported from the lungs to the organ and cell through the bloodstream to generate energy ATP.
At this time, ATP is used as an energy source for the vital activity of cells, and part of it is released as heat to the outside of the living body. This heat is detected as “body temperature”.

  The above “heart rate” or “pulse”, “blood pressure”, “respiration rate”, and “body temperature” are measured as basic vital signs during daily medical care. Measurement of these vital signs does not place a heavy burden on the subject, and at present, sufficiently accurate information can be obtained even with a simple measuring instrument. This simple measuring device is also commercially available as an electronic blood pressure monitor, an electronic thermometer, and the like. If these are used, each person's vital sign can be measured outside a medical institution. Moreover, if it records on a paper medium, a personal computer, etc. for every measurement, a temporal change can be left.

However, it is difficult to detect a sign of a serious illness by evaluating the vital signs measured so far. In other words, there is a limit to the information content of raw data as it is as vital sign data. Therefore, a new evaluation item was created by using a part of vital signs that have been measured.
This new evaluation item is a value obtained by dividing the pulse rate of the subject by the body temperature (Body Temperature) measured simultaneously. The pulse is the same as the heart rate, which is the heartbeat, and is controlled by the autonomic nerve.

Autonomic nerves include sympathetic nerves and parasympathetic nerves, and these two nerves control tension and relaxation. However, heart rate (pulse) is also affected by the hypothalamus and amygdala, which are the upper centers of the autonomic nerve. In particular, the amygdala is a center that catches various emotions, and it is the point that heart rate (pulse) changes due to changes in emotions. Furthermore, it has been revealed that the amygdala reacts sensitively to lactic acid generated in the living body.
In intracellular cellular substrates, lactic acid is synthesized from glucose via pyruvic acid in a glycolytic system. Lactic acid is synthesized from pyruvic acid when there is not enough oxygen present. The case where oxygen is deficient in a living body is when an inflammatory reaction occurs other than during intense physiological exercise.

In order to maintain homeostasis even in a normal state in a living body, various chemical reactions are performed dynamically, and lactic acid production varies. For this reason, even in a normal physiological state, the heart rate (pulse rate) varies according to the variation in the lactic acid level. However, when the tissues and cells maintain normal homeostasis, the heart rate (pulse) varies within a certain reference range.
In the case of an inflammatory reaction in which the lactic acid level increases, the heart rate (pulse) may consequently increase beyond the reference value. There are two main types of inflammatory reaction at this time.
The first reaction is an inflammatory reaction accompanied by an increase in body temperature such as an infectious disease or an autoimmune disease, and is often accompanied by fever.
The second reaction is a case where an ischemic change of a cell such as myocardial infarction or cerebral infarction occurs due to an inflammatory reaction other than an infection.

In order to distinguish the change in heart rate (pulse) between the first reaction and the second reaction, the heart rate (pulse) change and the presence or absence of fever associated with the reaction are confirmed.
Therefore, in the embodiment of the present invention, the pulse of the subject is measured. Furthermore, the body temperature of the subject is measured simultaneously with this pulse. Next, a value obtained by dividing the pulse by the body temperature is obtained as a new index, and the morbid state is evaluated from the non-disease state in the subject using this value.

  Furthermore, as shown in FIGS. 3 and 4, the embodiment of the present invention has an outlier 10 in which the value obtained by dividing the pulse by the body temperature deviates from the reference range, and a change point 11 that captures a situation in which the value gradually changes. Then, when the time series changes from the outlier 10 to the detection of the change point 11, the pathological state is evaluated from the non-disease state in the subject by the cumulative risk level that integrates the repeated risk levels.

1, 2, and 3 are plots of changes in pulse values, body temperature changes, and changes in values obtained by dividing the pulse by body temperature over time.
Furthermore, a correlation diagram of values obtained by dividing body temperature and pulse by body temperature is shown in FIG. When the temperature is over 37 ° C., the value obtained by dividing the pulse by the body temperature increases as the body temperature rises. FIG. 4 (above 37 ° C.) Show.
On the other hand, in the second reaction, the value obtained by dividing the pulse by the body temperature does not increase significantly in FIG. 4 (37 ° C. or lower). When the lactic acid level increases without a large increase in body temperature, oxygen deficiency in the cells, that is, ischemic changes such as myocardial infarction and cerebral infarction have occurred.
When the first reaction or the second reaction is detected, the first reaction and the second reaction are distinguished by changes in body temperature, alarm information as biological information is transmitted to the subject, and the onset of ischemic disease is detected. Foresee.

FIG. 5 shows an overall configuration diagram of an apparatus in the biological cell function evaluation method according to the embodiment of the present invention.
The measuring device 1a is a device that measures the pulse of the subject 1 and measures the body temperature of the subject 1 simultaneously with the pulse. The mobile phone 3 transmits the pulse and body temperature measured by the measuring instrument 1a to the computer 4. The computer 4 obtains a value obtained by dividing the pulse by the body temperature, and evaluates a morbid state from an unaffected state in the subject 1 based on the value. The computer program 4 a is recorded on a recording medium 4 b that is a hard disk of the computer 4 and controls the operation of the computer 4. The recording medium on which the computer program is recorded includes any recording medium such as a CD-ROM, the CD-ROM is inserted into the drive 4c, and the computer program 4a is installed and recorded on the recording medium 4b which is a hard disk. The

  Further, as shown in FIG. 5, the subject 1 himself / herself measures the pulse and body temperature using the measuring device 1a. A myocardial infarction and / or cerebral infarction that is an ischemic change in the body of the subject 1 is detected. In some cases, an infectious disease and / or an autoimmune disease that is an inflammatory reaction in the body of the subject 1 may be detected. When an ischemic change and / or an inflammatory reaction is detected, alarm information 5 is transmitted to the subject 1 as shown in FIG.

  The pulse 1 and the body temperature 2 which are vital signs information of the subject 1 are measured by the subject 1 himself with the measuring device 1a, periodically sampled through the mobile phone 3, and stored as time series data in the computer 4 of the medical institution or the inspection institution. To do. Each time the pulse and body temperature are sent to the computer 4 over time, a value obtained by dividing the pulse by the body temperature is calculated and added to the time series data. In the process, when the value obtained by dividing the pulse by the body temperature deviates from the constant reference range and becomes the outlier 10 shown in FIG. 3, some abnormality is caught. However, at that time, as shown in FIG. 4, it is necessary to distinguish whether there is an increase in body temperature or not. The outlier 10 is transmitted to the subject 1 as alarm information 5.

Further, not a sudden change such as an outlier 10, but a situation where a change is gradually occurring is detected as a change point 11 from an appropriate stage and an alarm is sounded. First, an abnormality is detected with an outlier 10, but if the outlier 10 is not so large, there is a risk of neglecting it. The change point 11 is important for detecting such a gentle change. This change point 11 is also transmitted to the subject 1 as alarm information 5.
If a continuous change is gradually shown while showing an intermittent change of the outlier 10 several times, an abnormality can be detected by detecting the change point 11.

Further, when the time series changes from the outlier 10 to the detection of the change point 11, the evaluation value such as the integrated risk is transmitted to the subject 1 as the alarm information 5 while integrating the repeated risks.
In addition, these data are periodically transmitted to the subject 1 as a report 6 with points to be noted.

1 Subject 1a Measuring instrument 2 Pulse / Body temperature 3 Mobile phone
4 Computer 4a Computer program 4b Recording medium 4c Drive 5 Alarm information 6 Report
10 Outlier 11 Change point

Claims (11)

Measure the subject's pulse,
Measure the subject's temperature at the same time as the pulse,
Find the pulse divided by the body temperature,
A method for evaluating a biological cell function, wherein a pathological state is evaluated from an unaffected state in the subject based on the value. An outlier that deviates from the reference range, and
Change points to capture the situation that is gradually changing,
The pathological state of the subject is evaluated from an unaffected state based on an accumulated risk level that accumulates repeated risk levels when the time series changes from the outlier to the detection of the change point. 2. The method for evaluating a biological cell function according to 1.   The method for evaluating a biological cell function according to claim 1, wherein the subject himself / herself measures the pulse and the body temperature using a measuring instrument.   4. The method for evaluating biological cell function according to claim 1, wherein myocardial infarction and / or cerebral infarction, which is an ischemic change in the body of the subject, is detected.   4. The method for evaluating a biological cell function according to claim 1, wherein an infectious disease and / or an autoimmune disease which is an inflammatory reaction in the body of the subject is detected.   6. The biological cell function evaluation method according to claim 4, wherein alarm information is transmitted to the subject when the ischemic change and / or inflammatory reaction is detected. The biological cell function evaluation method according to any one of claims 1 to 6,
A measuring instrument that measures the pulse of the subject and measures the temperature of the subject simultaneously with the pulse. The biological cell function evaluation method according to any one of claims 1 to 6,
A computer which calculates | requires the value which remove | divided the said pulse by the said body temperature, and evaluates a pathological state from the non-disease state in the said test subject by the said value.   A computer program for controlling the operation of the computer according to claim 8.   A recording medium for recording the computer program according to claim 9. A mobile phone that transmits the pulse and the body temperature measured by the measuring device according to claim 7 to the computer according to claim 8.

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