JP2011015862A - Method of discriminating sagging degree of skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a discriminating technique for easily and objectively estimating "the sagging degree of the skin" based on the correlation with skin functions such as the state of the tension and flexibility of the skin, and a technique of discriminating a skin sagging degree-improving effect by a cosmetic or an operation or the like using the discriminating technique.SOLUTION: The discriminating method is the method of discriminating the sagging degree of the skin, and the sagging degree of the skin defined as a visual and morphological skin sagging amount supported by a skin viscoelastic characteristics is estimated on the basis of the correlation of the sagging amount of the skin and the propagation time of shock waves.

Description

  The present invention relates to a method for discriminating the degree of skin talmi and a method for discriminating the effect of improving the degree of skin talmi by using cosmetics, massage, aesthetics and the like.

  Differentiation of skin condition is indispensable for accurately selecting cosmetics and accurately treating the skin, and various techniques for differentiation of skin conditions including questionnaires have been developed. . Among such discrimination methods, skin sagging, which is one of the aging phenomena, is the biggest concern for women over the middle age, and a method for distinguishing sagging skin easily and accurately, such skin Evaluation on the effects of cosmetics and treatments that can improve the condition was an important issue.

Under such circumstances, technologies for evaluating skin talmi from two aspects of skin functionality such as “skin elasticity and flexibility” and visual and morphological aspects have been researched and developed, respectively. As a technique focusing on functionality, for example, development of a skin viscoelasticity measuring instrument of a cutometer ^R manufactured by Courage + Khazaka (see Non-Patent Document 1) has been reported. In recent years, a shock wave measuring device (Reviscometer ^R manufactured by Courage + Khazaka Co.) that measures the shock wave transmitted to the skin, which can evaluate the state and direction of skin elasticity and flexibility, has been developed. Age-related changes in skin viscoelastic anisotropy of women (see Non-Patent Document 2), differences between regions related to skin hardness (see Non-Patent Document 3), and correlation with the feeling of tension (see Patent Document 2) It has been revealed. Moreover, the skin improvement effect by an active ingredient is also evaluated using these, The skin tightening effect (for example, refer patent documents 3 and 4) and the skin viscoelasticity fall inhibitory effect (for example refer patent document 5) are also disclosed. Has been.

  On the other hand, the development of technology for quantifying skin sagging with a focus on visual and morphological aspects has also been made, starting with expert judgments using reference pictures and judgments using moire images, and more objectively and quantitatively, supine position An apparatus for measuring the amount of sagging skin (see Patent Document 1) using the difference in the amount of displacement of the facial skin due to the difference in the gravity direction between the sitting position and the sitting position as an index is disclosed. Furthermore, a technique is also disclosed in which a non-contact type three-dimensional shape measuring apparatus is used to measure and evaluate the amount of change in the three-dimensional shape of the face before and after treatment and during daily fluctuations (see Patent Document 6).

  Such technological advancement has certainly improved the objectivity and accuracy of the amount of sagging skin, but the skin that governs the skin sagging and the flexibility and firmness of the skin. The relationship with the functionality of is still unknown. If the sagging of the skin based on the skin function of the present invention can be clarified (hereinafter defined as “the degree of skin talmi”), the active ingredient that can improve the skin function and the “degree of skin talmi” such as treatment are more objective. In addition, it is expected that it can be evaluated with high accuracy. Thus, a simple and objective technique capable of estimating “skin tarmi” based on skin function has been highly desired.

Japanese Patent Laid-Open No. 10-043141 JP 2004-160020 A JP 2006-232838 A JP 2008-533202 A JP 2009-007336 A JP 2004-113527 A Motoji Takahashi, FRAGRANCE JOURNAL 12:34, 1990 Keiichi Hamada, 51st SCCJ Research Discussion Meeting, 226 Tomomi Mori, Tokyo Institute of Technology Kurokawa Laboratory 2006 mid-term presentation

The present invention has been made under such circumstances, and easily and objectively estimates the “degree of skin itch” based on the correlation with skin functions such as the state of skin elasticity and flexibility. It is an object of the present invention to provide a technique for distinguishing the effect of improving the degree of sagging of the skin by cosmetics, treatment, and the like using the discrimination technique.

In view of such a situation, the present inventors have made extensive research efforts to find a technique for simply and objectively estimating the “degree of skin talmi”, and as a result, the sagging of the skin and the propagation time of the shock wave Based on the correlation, it has been found that the “degree of skin talmi” can be easily and objectively estimated, and the present invention has been completed. That is, this invention relates to the technique shown below.
(1) A method for discriminating the degree of skin talmi, which comprises estimating the degree of skin talmi using the propagation time of shock waves as an index.
(2) The skin tarmi according to (1) is characterized in that the discrimination of the degree of skin tarmi estimates the degree of skin tarmi based on the correlation between the amount of sagging skin and the propagation time of shock waves. Degree discrimination method.
(3) The average propagation time within the range of 110 ° to 170 ° or 290 ° to 340 ° with respect to the non-gravity direction in the standing posture with the propagation time of the shock wave centered on the measurement site on the skin surface (1) or (2), the method for distinguishing the degree of sagging of the skin according to (1).

  According to the present invention, it is possible to provide a technique capable of simply and objectively estimating the degree of skin talmi.

(1) Discrimination Method of Skin Talmi Degree of the Present Invention The discrimination method of skin tarmi degree of the present invention is characterized by estimating the degree of skin tarmi using the propagation time of shock waves. In order to perform the discrimination, a relationship between the amount of sagging skin and the propagation time of the shock wave is clarified, and a regression equation or the like indicating the relationship is prepared and used for discrimination. The details are as follows.

(2) Visual and morphological measurement of skin sagging amount The mechanism of skin sagging is not well understood, but changes in skin, muscle and subcutaneous fat with aging and its balance with aging are not well understood. It is thought that the influence of the collapse, the change of the dermis of the skin maintaining the strength of elasticity and flexibility, the influence of gravity, etc. are involved. As described above, the amount of sagging skin can be quantified visually and morphologically. For example, visual or photographic evaluation, moire measurement, skin sagging amount measuring device, or three-dimensional measuring device can be used. The “sagging amount of skin” can be measured. The three-dimensional measuring device is commercially available as a non-contact type three-dimensional shape measuring device, and uses it to measure various postures and three-dimensional coordinates of the face over time, and the displacement is expressed as a numerical value (mm or cm ³ ). Available. As such an apparatus, for example, a three-dimensional measuring device such as “Danae-R Range Finder” manufactured by NEC Engineering Co., Ltd. or “VIVID Series” manufactured by Konica Minolta Co., Ltd. can be preferably exemplified. The skin sag measuring device measures the distance between the reference point of the skin and the measurement point to be sagged, and the displacement of the distance between the sitting position and the supine position is defined as the amount of sagging due to gravity (mm). Defined and available as a number. This apparatus is a simple method that can be measured only with a measure and a digital camera, and can be measured with higher accuracy by combining with an image analysis apparatus.

(3) Measuring method of shock wave propagation time showing skin functional characteristics Examples of skin functional characteristics include skin viscoelasticity measuring device and shock wave measuring device, more preferably a shock wave measuring device for measuring shock waves transmitted to the skin, Specifically, Courage + Khazaka Co. Ribisukometa (Reviscometer ^R) can be suitably exemplified. This apparatus can measure the propagation time (unit: arbitrary value, hereinafter abbreviated as RRT) of a shock wave between two sensors (Emitter / Receiver) at the probe tip (see FIG. 1). Actually, attachments are attached to the target region in increments of 10 °, and 0 to 350 ° are measured, and 36 pieces of RRT data can be obtained (see FIGS. 2 and 3). It is known that the RRT thus obtained reflects elasticity or elasticity, and that the elasticity is low when the RRT is large.

(4) Correlation between skin sagging and shock wave propagation time Visual and morphological skin as described above for sites suitable for observing sagging skin, such as the cheeks and jaws If the measurement of the amount of sagging and the measurement of the shock wave propagation time indicating skin function characteristics are performed on a sufficient number of subjects and a significant and high correlation is shown between the two measurement indices, It can be seen that the morphological skin sagging amount reflects viscoelastic skin functions such as RRT. In other words, it can be said that it is possible to estimate the “degree of skin talmi” using RRT or the like. Specifically, by creating regression equations that show the relationship between the two, it is possible to estimate “the degree of skin talmi”, which is defined as the amount of visual and morphological skin sagging supported by skin functional characteristics. .

  The confirmation of the correlation and the creation of the regression equation can be executed using free software or commercially available multivariate analysis software, and examples thereof include SPSS series manufactured by SPSS and JMP manufactured by SAS.

Thus, if the measurement of the amount of sagging of the skin visually and morphologically and the measurement of the shock wave propagation time etc. showing the skin function characteristics, and showing a significant and high correlation between both measurement indices, It is possible to estimate “skin degree of skin”, which is defined as visual and morphological skin sagging backed by skin functional characteristics. Therefore, the index of the skin function characteristic is not limited to the shock wave propagation time (RRT), and is not particularly limited as long as it is a skin rheology characteristic measuring instrument capable of measuring an index satisfying the above correlation. Can be used without receiving. The Such devices, for example, Wave cyber Co. Vesmeter ^R, Courage + Khazaka Co. cute meter ^R and Skin-Elastometer ^R, Paula Co. skin Rejiriometa or AXIOM Co. Venustron series like.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to these examples.

<Relationship between skin sagging amount and shock wave propagation time>
<Method>
For 58 volunteers in their 20s to 70s, RRT is a viscometer (Reviscometer RRVM600), and skin sagging is measured using an image analyzer and the skin sagging measuring device described above, after 2 hours of face washing. Measurement was performed under conditions and sites as shown in FIG. The correlation between the obtained RRT (arbitrary value) and the amount of sag (mm) was analyzed, and the results are shown in Table 1.
<Result>
From Table 1, it is shown that the RRT, which is the shock wave propagation time, and the amount of sagging skin have a significant and high correlation (p <0.05) at the RRT angles of 110 to 170 ° and 290 to 340 ° in the cheek. I understand.

<Differential discrimination of skin tarmi>
In Example 1, the average value for each individual RRT in the range of 110-170 ° RRT showing a significant correlation (defined as an angle-dependent skin elasticity index: the larger the value, the lower the elasticity) is calculated. Then, correlation analysis and regression analysis were performed on the angle-dependent skin elasticity index and the amount of sagging skin (see FIG. 6). As shown in the results of FIG. 6, a significant positive correlation (r = 0.368, p <0.01) can be confirmed. It can be seen that by using the obtained regression analysis formula, it is possible to discriminate the “degree of skin talmi”, which is defined as the amount of sagging of the visual morphological skin, which is supported by the skin viscoelastic characteristics meant by RRT.

<Relationship between daily fluctuation of skin sagging and propagation time of shock wave>
Using the “Danae-R Range Finder” manufactured by NEC Engineering, targeting 24 of the volunteers in Example 1, the three-dimensional shape of the face was measured in the sitting position at 10 am and 5 pm. The difference was calculated. At 5:00 pm, a positive difference (swelling) in the normal direction was observed from the cheek to the chin (0.85 mm ± 0.40 mm, p <0.001), indicating diurnal variation in skin sagging due to gravity. . As a result of analyzing the correlation with RRT (min) in the same manner as in Example 1 by using the positive difference in the normal direction in the cheek of FIG. 5 as the amount of sagging skin (mm), a significant and high correlation (r = 0.568, p <0.01) was confirmed. From this, it can be seen that the “degree of skin talmi”, which is defined as the amount of sagging of the visual morphological skin, which is supported by the skin viscoelastic characteristics meant by RRT, can be identified.

<Test example>
38 volunteers in their 30s and 50s were divided into two groups, and the effect of improving skin viscoelasticity by cosmetics was examined by a double blind method. In one of the two groups, a cosmetic containing a mugwort extract ^*, which is expected to improve skin viscoelasticity, and a cosmetic containing no mugwort extract are used for 6 months, and the same method as in Example 1 is used. Before and after use, RRT (min), angle-dependent skin elasticity index and sagging amount (mm) were measured. The results of analysis by t-test are shown in FIGS. The angle-dependent skin elasticity index and sagging amount (mm) related to “degree of skin talmi” showed a significant difference in the index depending on the presence or absence of mugwort extract ^* , indicating a tendency to improve skin viscoelasticity. From this, it is understood that the index of “degree of skin talmi” is effective.
^* Plant extracts of plants belonging to the genus Artemisia

  According to the present invention, it is possible to provide a technique capable of simply and objectively estimating the degree of skin talmi supported by the skin function, and distinguishing the effect of improving the degree of skin talmi by cosmetics, active ingredients, various treatments, etc. Can do.

It is a figure which shows the probe principle of a riviscometer. It is a figure which shows the skin measurement using the attachment of a riviscometer. It is a figure (example) which shows the output result of RRT when 0-360 degrees is measured by a riviscometer. It is a figure which shows the principle of the measuring method of the face in a skin sagging amount measuring apparatus. It is a figure which shows the measuring method of the face by a riviscometer. It is a figure which shows the correlation with an angle dependence skin elasticity index and skin sagging amount. It is a figure which shows the improvement result of RRT in a skin viscoelasticity improvement test. It is a figure which shows the result of the amount of sagging (mm) in a skin viscoelasticity improvement test.

Claims (3)

A method for discriminating the degree of skin italian, characterized by estimating the degree of skin italian using the propagation time of shock waves as an index. 2. The degree of the degree of skin talmi according to claim 1, wherein the discrimination of the degree of skin talmi is based on a correlation between the degree of skin talmi and a propagation time of a shock wave. Identification method. The propagation time of the shock wave is an average value of the propagation time in the range of 110 ° to 170 ° or 290 ° to 340 ° with respect to the non-gravity direction in the standing posture with the measurement site on the skin surface as the center. The method for discriminating the degree of sagging of the skin according to claim 1 or 2, characterized in that:

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