JP2010536876A5 - - Google Patents
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- JP2010536876A5 JP2010536876A5 JP2010522030A JP2010522030A JP2010536876A5 JP 2010536876 A5 JP2010536876 A5 JP 2010536876A5 JP 2010522030 A JP2010522030 A JP 2010522030A JP 2010522030 A JP2010522030 A JP 2010522030A JP 2010536876 A5 JP2010536876 A5 JP 2010536876A5
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- JP
- Japan
- Prior art keywords
- dihydro
- pyrrolo
- compound
- composition
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 —CH 2 -aryl Chemical group 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 201000011510 cancer Diseases 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 208000035475 disorder Diseases 0.000 claims description 9
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- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims description 8
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- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 4
- KYRVNWMVYQXFEU-UHFFFAOYSA-N Nocodazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=CS1 KYRVNWMVYQXFEU-UHFFFAOYSA-N 0.000 claims description 4
- 229930012538 Paclitaxel Natural products 0.000 claims description 4
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- XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 claims description 4
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- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims description 4
- 101150044616 araC gene Proteins 0.000 claims description 4
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
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- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 4
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- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 4
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 208000024207 chronic leukemia Diseases 0.000 claims description 2
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- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
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- 208000029824 high grade glioma Diseases 0.000 claims description 2
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- 208000032839 leukemia Diseases 0.000 claims description 2
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- 201000001441 melanoma Diseases 0.000 claims description 2
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- WQFNMMAWEXUDIB-UHFFFAOYSA-N n-(6-oxoheptyl)-5,6-dihydro-4h-pyrrolo[3,2,1-ij]quinoline-1-carboxamide Chemical compound C1CCC2=CC=CC3=C2N1C=C3C(=O)NCCCCCC(=O)C WQFNMMAWEXUDIB-UHFFFAOYSA-N 0.000 claims description 2
- XFHLLPYFEXLXMN-UHFFFAOYSA-N n-[7-(hydroxyamino)-7-oxoheptyl]-5,6-dihydro-4h-pyrrolo[3,2,1-ij]quinoline-1-carboxamide Chemical compound C1CCC2=CC=CC3=C2N1C=C3C(=O)NCCCCCCC(=O)NO XFHLLPYFEXLXMN-UHFFFAOYSA-N 0.000 claims description 2
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- SESSWCGDZHNKHR-UHFFFAOYSA-N n-benzyl-n-[7-(hydroxyamino)-7-oxoheptyl]-5,6-dihydro-4h-pyrrolo[3,2,1-ij]quinoline-1-carboxamide Chemical compound C=1N(C=23)CCCC3=CC=CC=2C=1C(=O)N(CCCCCCC(=O)NO)CC1=CC=CC=C1 SESSWCGDZHNKHR-UHFFFAOYSA-N 0.000 claims description 2
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|---|---|---|---|
| US96558407P | 2007-08-21 | 2007-08-21 | |
| PCT/US2008/073873 WO2009026446A2 (en) | 2007-08-21 | 2008-08-21 | Hdac inhibitors |
Publications (2)
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| JP2010536876A JP2010536876A (ja) | 2010-12-02 |
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| CN (1) | CN101835778A (cg-RX-API-DMAC7.html) |
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| WO2010023307A1 (en) | 2008-08-29 | 2010-03-04 | Topotarget A/S | Novel urea and thiourea derivatives |
| WO2011082266A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted heterocyclic compounds |
| US20110212969A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2011106627A1 (en) | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2013041407A1 (en) * | 2011-09-19 | 2013-03-28 | Cellzome Ag | Hydroxamic acids as hdac6 inhibitors |
| JP6272773B2 (ja) * | 2011-11-29 | 2018-01-31 | ナンジン アルゲン ファルマ カンパニー リミテッドＮａｎｊｉｎｇ Ａｌｌｇｅｎ Ｐｈａｒｍａ Ｃｏ． Ｌｔｄ． | Ｈｄａｃ６阻害剤・抗腫瘍剤用複素環アミド化合物 |
| EP2836484B1 (en) | 2012-04-10 | 2017-06-14 | Annji Pharmaceutical Co., Ltd. | Histone deacetylases (hdacs) inhibitors |
| US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| WO2014178606A1 (en) * | 2013-04-29 | 2014-11-06 | Chong Kun Dang Pharmaceutical Corp. | Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same |
| US11535598B2 (en) | 2017-05-16 | 2022-12-27 | Annji Pharmaceutical Co., Ltd. | Histone deacetylases (HDACs) inhibitors |
| CN113121527B (zh) * | 2019-12-31 | 2024-09-06 | 上海辉启生物医药科技有限公司 | 三环类化合物及其用途 |
| JP2023530788A (ja) | 2020-06-08 | 2023-07-19 | アンジー ファーマシューティカル カンパニー リミテッド | 選択的ｈｄａｃ６阻害剤として有用なキナゾリン誘導体 |
| CN119143740B (zh) * | 2024-08-15 | 2025-11-14 | 杭州科兴生物化工有限公司 | 一种苯并噻吩类衍生物及其制备方法与应用 |
Family Cites Families (4)
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| DE60115279T2 (de) * | 2000-09-29 | 2006-12-28 | Topotarget Uk Ltd., Abingdon | Carbaminsäurederivate enthaltend eine amidgruppe als hdac-inhibitoren |
| AR035417A1 (es) * | 2001-01-27 | 2004-05-26 | Hoffmann La Roche | Derivados triciclicos de lactama y sultama, procesos para su elaboracion, medicamentos que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos |
| WO2005007091A2 (en) * | 2003-07-07 | 2005-01-27 | Georgetown University | Histone deacetylase inhibitors and methods of use thereof |
| ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
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2008
- 2008-08-21 US US12/671,351 patent/US20100261710A1/en not_active Abandoned
- 2008-08-21 EP EP08827808A patent/EP2190845A2/en not_active Withdrawn
- 2008-08-21 WO PCT/US2008/073873 patent/WO2009026446A2/en not_active Ceased
- 2008-08-21 CA CA2695452A patent/CA2695452A1/en not_active Abandoned
- 2008-08-21 JP JP2010522030A patent/JP2010536876A/ja not_active Withdrawn
- 2008-08-21 CN CN200880112378A patent/CN101835778A/zh active Pending
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