JP2010531295A5

JP2010531295A5 -

Info

Publication number: JP2010531295A5
Application number: JP2010503277A
Authority: JP
Filing date: 2008-04-14
Publication date: 2010-11-04

Claims

Reaction chamber;
One or more flow channels connected to the reaction chamber;
One or more vents connected to the top of the reaction chamber , the vent configured to allow unrestricted solvent evaporation from the reaction chamber ; and performing flow control to and from the reaction chamber One or more integral valves for
A microfluidic chip for radiosynthesis of radiolabeled compounds.

The chip according to claim 1, wherein the reaction chamber is located inside a reactor part and a lid part of the chip fitted with pressure.

The chip according to claim 2, wherein at least a part of the lid is transparent.

The chip of claim 1 comprising a replaceable component and machined using computer numerical control (CNC) technology.

The chip according to claim 1, wherein the reactor has a cylindrical shape having an aspect ratio of 1: 1.

The chip according to claim 1, which has a hexagonal shape.

Said reaction chamber Ri name further comprises a heater for heating, the heater according to claim 1 that is connected to the chip through an opening in the bottom surface of said chip chip.

The chip according to claim 7 , wherein the heater is separated from the side wall of the opening by a gap.

The chip of claim 7 , wherein the heater is separated from the reaction chamber by a 250 micron portion.

The chip of claim 9 , wherein the portion comprises a doped DCPD material.

Chip of claim 1 wherein the reaction chamber is one having a capacity of cylindrical及beauty 6 0μL.

The tip of claim 1 , wherein one or more syringes are used to deliver at least one fluid or gas to the tip.

Further modified to communicate with a network of fluid and gas delivery and removal, the network modified to work with at least one of prefilled individual vials and prepackaged cartridges, and the cartridge The tip of claim 1, wherein the tip contains a pre-weighed amount of reagent sufficient for a single use with the tip.

A microfluidic chip configured to allow unlimited solvent evaporation from the reaction chamber ;
A reagent source in fluid communication with the chip and containing at least one reagent;
Fluid delivery and removal network;
A controller modified to control the operation of the network; and a local radiation shield for shielding one or more radiation-critical components of the device;
Portable device for automated radiosynthesis of radiolabeled compounds.

15. The device of claim 14 , further comprising a camera for monitoring the reaction chamber, the temperature monitoring further comprising a feedback loop driven by a machine vision system for analyzing reactions in real time .

The device of claim 14 , wherein the controller comprises a programmable logic controller and a user interface.

The device of claim 16 , wherein the user interface is configured to perform at least one of manual operation and automatic operation of the device.

15. The device of claim 14, further comprising a radiation shield that allows a user to access the reagent without being exposed to radiation.

The device of claim 14, further comprising a complementary portable “plug-in” bottle for transferring radioactive material to or from the device without the user being exposed to radiation.

Reaction chamber;
One or more flow channels connected to the reaction chamber;
One or more vents connected to the top of the reaction chamber, the vent configured to allow unlimited solvent evaporation from the reaction chamber; and
One or more integrated valves for performing flow control into and out of the reaction chamber;
The integral valve is configured to receive one or more plunger assemblies that allow priming of reagents outside the reaction chamber;
The valve is a dumbbell-type plunger that allows reagent priming;
A microfluidic chip for radiosynthesis of radiolabeled compounds.

21. The microfluidic chip according to claim 20, wherein the valve plunger comprises a Teflon chip.

21. The microfluidic chip of claim 20, wherein the valve is a vent valve having an O-ring that provides sealing and allows a large channel cross-sectional area.

21. The microfluidic chip of claim 20, wherein the valve is configured to perform a reaction at a high pressure greater than 300 psi.

Introducing one or more reagents into the microfluidic chip;
Where the chip is
A reaction chamber;
One or more flow channels connected to the reaction chamber;
One or more vents connected to the reaction chamber, the vent configured to allow unlimited solvent evaporation from the reaction chamber ;
One or more integrated valves for controlling the flow into and out of the reaction chamber,
Treating said reagent to produce a radiolabeled compound; and collecting said radiolabeled compound;
A method for radiosynthesis of radiolabeled compounds.

25. The method of claim 24, wherein radiosynthesis of the radiolabeled compound is performed in batch mode using a microfluidic chip.

The method of claim 24, wherein the introduction of the reagent comprises a self-metering of the reagent.

25. The method of claim 24, wherein the process steps of radiosynthesis of the radiolabeled compound further comprise mixing and heating reagents and exchanging solvents.

27. The method of claim 26, wherein heating the reagent comprises overheating the contents of the reaction chamber by closing the vent and heating the reaction chamber with a heater.

29. The method of claim 28, comprising pressurizing the reaction chamber prior to applying the heater.

28. The method of claim 27, wherein heating and boiling of the reagent facilitates mixing of the reagent.

25. The method of claim 24, further comprising effective evaporation of the solvent, resulting in a product residue without a subsequent drying step.

25. The method of claim 24, wherein the solvent is evaporated below its boiling point without applying a vacuum.

A method for concentrating F-18 requiring a microfluidic off-chip having a microliter scale ion exchange bed capacity, wherein the microfluidic chip is the chip of claim 1.

34. The method of claim 33, wherein the capture and release of the fluoride (F-18) solution occurs in the opposite direction.

35. A method according to claim 33 or 34, wherein the fluoride release is divided into small fractions.

Dilute H with 2 mL fluoride ₂₂ ¹⁸¹⁸ Only 5 μL of K captured from O ₂₂ CO _3Three 36. The method of claim 35, wherein the method is transferred to a solution.

34. The method of claim 33, wherein a capture and release system is incorporated to efficiently transport [F-18] fluoride ions from the microscopic environment to the macroscopic environment with an efficiency greater than 99%.

38. The method of claim 37, comprising using an integrated device comprising the chip of claim 1, wherein the device is integrated with an ion exchange column.

40. The method of claim 38, wherein all steps of radiosynthesis are performed automatically starting from the target water and producing an injectable radiopharmaceutical.