JP2010501624A - 新規なピペリジン誘導体及びモノアミン神経伝達物質再取込み阻害剤としてのその使用 - Google Patents
新規なピペリジン誘導体及びモノアミン神経伝達物質再取込み阻害剤としてのその使用 Download PDFInfo
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- JP2010501624A JP2010501624A JP2009526087A JP2009526087A JP2010501624A JP 2010501624 A JP2010501624 A JP 2010501624A JP 2009526087 A JP2009526087 A JP 2009526087A JP 2009526087 A JP2009526087 A JP 2009526087A JP 2010501624 A JP2010501624 A JP 2010501624A
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- Prior art keywords
- disorder
- piperidine
- dichloro
- pain
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-M mandelate Chemical compound [O-]C(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-M 0.000 description 1
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- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
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- 235000021096 natural sweeteners Nutrition 0.000 description 1
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- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
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- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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Landscapes
- Health & Medical Sciences (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
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- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200601118 | 2006-08-30 | ||
| US82413806P | 2006-08-31 | 2006-08-31 | |
| PCT/EP2007/058951 WO2008025777A1 (en) | 2006-08-30 | 2007-08-29 | Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010501624A true JP2010501624A (ja) | 2010-01-21 |
| JP2010501624A5 JP2010501624A5 (enExample) | 2010-10-07 |
Family
ID=43607851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009526087A Abandoned JP2010501624A (ja) | 2006-08-30 | 2007-08-29 | 新規なピペリジン誘導体及びモノアミン神経伝達物質再取込み阻害剤としてのその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110046179A1 (enExample) |
| EP (1) | EP2059506A1 (enExample) |
| JP (1) | JP2010501624A (enExample) |
| WO (1) | WO2008025777A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106187999A (zh) * | 2015-05-04 | 2016-12-07 | 复旦大学 | 取代哌啶类化合物及其制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| CA2502704A1 (en) * | 2002-11-01 | 2004-05-13 | Neurosearch A/S | Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1761493A2 (en) * | 2004-06-18 | 2007-03-14 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
-
2007
- 2007-08-29 EP EP07802968A patent/EP2059506A1/en not_active Withdrawn
- 2007-08-29 US US12/377,830 patent/US20110046179A1/en not_active Abandoned
- 2007-08-29 WO PCT/EP2007/058951 patent/WO2008025777A1/en not_active Ceased
- 2007-08-29 JP JP2009526087A patent/JP2010501624A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110046179A1 (en) | 2011-02-24 |
| EP2059506A1 (en) | 2009-05-20 |
| WO2008025777A1 (en) | 2008-03-06 |
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