JP2010240189A - Medicinal solution spraying device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To reliably administer a prescribed amount of a medicinal solution to a target region inside a living body by easily introducing the medicinal solution to the inside of the living body. <P>SOLUTION: A medicinal solution spraying device 1 for administering the medicinal solution D to a target region inside the living body by spraying includes a holding member 2 held while being positioned relative to the target region, a supply hole 25 provided on the holding member for introducing the medicinal solution from one end to the other end, a medicinal solution supply part 4 mounted on the supply hole and for supplying the medicinal solution to the supply hole, a spraying port 9 for spraying the medicinal solution supplied to the supply hole, a voltage applying part 5 for applying a voltage to the medicinal solution, a ground part 6 electrically connected to the voltage applying part, and an electrical conduction part which is electrically connected to the ground part, is provided at least on a part of an outer surface of the holding member, and has conductivity. The medicinal solution spraying device 1 for spraying the medicinal solution in the form of mists from the spraying port to the region inside the living body with a potential different from that of the medicinal solution at the spraying port while the medicinal solution is charged by the voltage applying part is provided. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a chemical liquid spraying apparatus for spraying a chemical liquid containing a drug on a predetermined site such as a subject.

Conventionally, a drug solution or the like has been administered to a predetermined site such as an affected part of a subject (living body).
For example, as shown in Patent Document 1, a catheter assembly including a catheter that delivers a drug solution to a target site in the body is known. As an urging mechanism in the catheter assembly, for example, a mechanism using a pressurized gas, vacuum, centripetal force, plunger, potential gradient or the like can be employed. When utilizing the potential gradient as the biasing mechanism, the catheter has a full length lumen, a proximal end containing an active electrode, a distal end containing a counter electrode and a nozzle, and a battery or pulse generator as a source of electrical energy. The structure which has a vessel etc. is taken. An active electrode and a counter electrode are connected to the electric energy source.
Then, the charged therapeutic agent moves due to the potential gradient between the two electrodes, and reaches the target site through the nozzle portion.

JP-T-2006-527023

  However, in the catheter assembly shown in Patent Document 1, since only a potential difference is provided between the proximal end electrode and the distal end electrode, the particulate therapeutic agent released from the nozzle portion is used. In this case, only gravity acts, and it is not affected by the potential gradient. For this reason, there has been a problem that administration of the chemical solution tends to be insufficient as a result of the fine particles of the administered chemical solution being likely to rise without adhering to a predetermined site.

  The present invention has been made in view of such problems, and it is possible to easily introduce a chemical solution into a living body and reliably administer a predetermined amount of the chemical solution to a predetermined site in the living body. Provided is a chemical spraying device that can be used.

In order to solve the above problems, the present invention proposes the following means.
The medicinal-solution spraying device of the present invention is a medicinal-solution spraying device for spraying and administering a medicinal solution to a target site inside a living body, and is held in a state of being positioned with respect to the target site, and the holding member A supply hole for guiding the chemical liquid from one end to the other end; a chemical supply section that is attached to the supply hole and supplies the chemical liquid to the supply hole; and the supply hole. A spray port for spraying the supplied chemical liquid, a voltage application section for applying a voltage to the chemical liquid, a ground section electrically connected to the voltage application section, and electrically connected to the ground section, at least An electrically conductive part having electrical conductivity provided on a part of the outer surface of the holding member, and the raw liquid different from the potential of the chemical liquid at the spray port in a state where the chemical liquid is charged by the voltage application part. Towards a part of the body It is characterized by spraying the serial spray nozzle in a mist form.

  According to this invention, when the holding member is held in a state of being positioned with respect to the target site inside the living body, at least the electric conduction portion provided on a part of the outer surface of the holding member is a part of the living body. Contact. At this time, since the living body and the voltage application unit are electrically connected via the electric conduction unit and the ground unit, the potential difference between the voltage application unit and the living body can be kept constant. For this reason, the chemical solution supplied by the chemical solution supply unit is guided to the spray port through the supply hole provided in the holding member in a state where a stable voltage is applied by the voltage application unit. Here, since the holding member is held in a state of being positioned inside the living body, the chemical liquid supplied by the chemical liquid supply unit is guided into the living body by passing through the supply hole. Moreover, since the chemical | medical solution in a spray port has a stable electric potential difference between the biological bodies, it is sprayed in the shape of a mist in the charged state, and adheres reliably to the site | part in a biological body as a fine particle of a chemical | medical solution. As a result, a chemical solution can be easily introduced into the living body and a predetermined amount of the chemical solution can be reliably administered to a predetermined site in the living body.

Further, the chemical spray apparatus includes a case body that accommodates at least a part of the chemical liquid supply unit and the voltage application unit, and the ground unit is disposed on the case body so as to contact the electric conduction unit. It is good to be.
According to this invention, the chemical solution supply part is attached to the supply hole provided in the holding member, and the ground part and the electric conduction part are electrically connected by bringing the ground part arranged in the case body into contact with the electric conduction part. Connected. Thereby, the potential difference between the voltage application unit and the inside of the living body can be kept constant.

In the chemical solution spraying apparatus, the chemical solution supply unit includes a tube body provided with the spray port at a distal end portion, and the case body is in contact with a peripheral portion of one opening of the supply hole. And having a restricting portion that restricts the length of insertion of the tube body into the supply hole, and the ground portion is formed when the restricting portion is brought into contact with a peripheral edge portion of the one opening. It is good also as arrange | positioning so that it may contact | abut an electric conduction part.
According to the present invention, when the tube body is inserted into the supply hole and the regulating portion of the case body is brought into contact with the peripheral edge portion of the one opening of the supply hole, the ground portion is in contact with the electric conduction portion, The length by which the tube body is inserted into the supply hole is restricted. Then, the spray port is positioned in the axial direction of the tube body with respect to the holding member.
Here, since the holding member is held in a state of being positioned with respect to the target site inside the living body, the spray port is also positioned with respect to the target site. For this reason, the position of the spray port can be stabilized inside the living body, and the potential difference between the voltage applying unit and the inside of the living body can be kept constant.

Further, in the chemical solution spraying apparatus, the chemical solution supply unit includes a tube body formed of an insulating material, the spray port being provided at a distal end portion, and the ground portion is disposed outside the tube body. A conductive layer provided on the surface and electrically connected to the voltage application unit; and when the tube body is inserted into the supply hole, the conductive layer slides on the inner peripheral surface of the supply hole. It is good also as being comprised so that it may contact | connect.
According to this invention, according to this invention, the tube body is inserted into the supply hole provided in the holding member, and the conductive layer provided on the outer surface of the tube body is slid on the inner peripheral surface of the supply hole. By making contact, electrical continuity between the ground portion and the electric conduction portion of the holding member can be obtained.

In the above chemical spraying device, the electric conduction portion may be a conductive material that forms the holding member.
According to the present invention, the holding member provided with the electric conduction portion can have a simple structure.

Further, in the above-described chemical spraying device, the holding member may be formed with an insertion hole through which the insertion portion of the endoscope is inserted to guide the insertion portion into the living body.
According to this invention, it is possible to perform the spraying of the chemical solution and the insertion of the endoscope into the living body while the holding member is held by the living body.

  According to the medicinal solution spraying apparatus of the present invention, a medicinal solution can be easily introduced into a living body, and a predetermined amount of medicinal solution can be reliably administered to a predetermined site in the living body.

It is sectional drawing of the test subject's head which shows the anesthetic administration position of the throat part for demonstrating the Example of this invention. It is sectional drawing when the chemical spraying apparatus of 1st Embodiment of this invention is applied to a mouth part. It is sectional drawing of the main-body part of the chemical | medical solution spraying apparatus. Fig.4 (a) is sectional drawing of the mouthpiece of the chemical | medical solution spraying apparatus, FIG.4 (b) is an A1 direction arrow directional view in Fig.4 (a). FIG. 5 (a) is an explanatory view schematically showing a spray state when the oral surface of the subject is 0V, and FIG. 5 (b) is a case where the subject is charged to the positive pole side as a comparative example. It is explanatory drawing which showed typically the spraying state of the anesthetic. Fig.6 (a) is sectional drawing when the chemical | medical solution spraying apparatus of 2nd Embodiment of this invention is applied to an opening | mouth part, FIG.6 (b) is A2 direction arrow line view in Fig.6 (a). It is sectional drawing when the chemical spraying apparatus of 3rd Embodiment of this invention is applied to a mouth part.

(First embodiment)
Hereinafter, a first embodiment of a chemical spraying apparatus according to the present invention will be described with reference to FIGS. 1 to 5.
This chemical solution spraying device is a device that atomizes a charged chemical solution (chemical solution) and sprays it on a predetermined site (target site) in a mouth portion of a subject (living body) such as an oral cavity, a nostril, or an ear canal.
The medicinal solution spray device of this embodiment is used to administer a medicinal solution when, for example, the tonsils, uvula, nasal cavity or ear canal are inflamed. In the following embodiments, an example will be described in which a liquid anesthetic is administered to the throat (predetermined site) in the oral cavity using a chemical spray apparatus, and then the throat is observed with an endoscope. In addition, as a chemical | medical solution (medicine) to be used, not only an anesthetic, but various chemical | medical agents are applicable if it is a chemical | medical agent which can be prepared as a chemical | medical solution like a therapeutic agent.

  As shown in FIG. 1, many parts that feel burdened by contact with the endoscope are concentrated in the back of the oral cavity, the range R1 of the throat T, and when the throat T is observed with the endoscope, It is desired to anesthetize this range R1 with an anesthetic.

As shown in FIG. 2, the chemical spraying device 1 includes a substantially cylindrical mouthpiece (holding member) 2 and a device main body 3 that is used by being attached to the mouthpiece 2. The mouthpiece 2 is configured to be held by biting with the upper and lower teeth H2 in the mouth portion H1. Thereby, the mouthpiece 2 is held in a state of being positioned with respect to a predetermined part (target part) in the living body.
As shown in FIG. 3, the apparatus main body 3 includes a chemical solution supply unit 4 that supplies the anesthetic D, a voltage application unit 5 that applies a voltage to the anesthetic D, and a main body that is electrically connected to the voltage application unit 5. Side contact (ground portion) 6. In the present embodiment, the apparatus main body 3 includes a substantially box-shaped case body 7 that houses a part of the chemical solution supply unit 4, the voltage application unit 5, and the main body side contact 6.

  The chemical solution supply unit 4 is connected to a spray nozzle (tube body) 10 in which a spray port (spray hole) 9 for spraying the anesthetic D in a mist form at the tip is formed, and a base end of the spray nozzle 10. And a syringe 11 filled with an anesthetic D. A circular tube-shaped voltage application electrode 12 is provided at the tip of the syringe 11.

The spray nozzle 10 is a tubular member made of, for example, a non-conductive material made of tetrafluoroethylene resin and having flexible flexibility and insulation. The spray port 9 is formed in a resin cap 13 that is provided by being bonded and fixed to the tip of the spray nozzle 10. The outer diameter of the resin cap 13 is set to be substantially the same as the outer diameter of the spray nozzle 10. In addition, the outer diameter, inner diameter, length of the spray nozzle 10, the inner diameter of the spray port 9, and the like are appropriately set according to the type of the chemical solution, the target site in the living body, and the like. In the present embodiment, the outer diameter, inner diameter, and length of the spray nozzle 10 are set to be 1 mm, 0.7 mm, and 100 mm, respectively, and the inner diameter of the spray port 9 is set to 0.1 mm.
The syringe 11 has a cylinder member 14 that is connected to the proximal end portion of the voltage application electrode 12 and that is filled with the anesthetic D, and a piston member 15 that is slidably inserted into the cylinder member 14.

The base end portion of the spray nozzle 10 is attached in the case body 7 through a hole 7 b formed in the side surface 7 a of the case body 7. The voltage application electrode 12 is detachable from an electrode contact member 20 described later.
The spray nozzle 10, the syringe 11, and the voltage application electrode 12 are detachably attached to the case body 7 through an opening (not shown) covered with a lid (not shown), and are used as disposable parts. Depending on the usage, it is discarded after use.
In the case body 7, a hole 7c is formed at a position facing the hole 7b, and the proximal end side of the piston member 15 is exposed from the hole 7c. For this reason, by pushing the piston member 15 into the cylinder member 14, the anesthetic D filled in the cylinder member 14 can be fed to the spray port 9 through the voltage application electrode 12 and the spray nozzle 10. It has become.
The spray nozzle 10 is inserted into a supply hole (described later) of the mouthpiece 2, and the apparatus body 3 is attached to the mouthpiece 2. At this time, the side surface 7a of the case body 7 constitutes a regulating portion that regulates the length of the spray nozzle 10 inserted through the supply hole by being brought into contact with the peripheral edge portion of one opening of the supply hole.

  The voltage application unit 5 switches the operation / stop state of the power source 18 such as a battery, the voltage generation circuit 19 that boosts the voltage of the power source 18, the electrode contact member 20, the voltage application electrode 12, and the voltage generation circuit 19. And a switch 21. The voltage generation circuit 19 is electrically connected to the power source 18, the electrode contact member 20, and the operation switch 21.

The voltage generation circuit 19 boosts the voltage of the power supply 18 from a high-voltage transformer (piezoelectric method or winding method) to generate a high voltage, for example, an applied voltage of about 5 kV, and the generated high voltage is applied to the electrode contact member 20. To the voltage application electrode 12.
The operation of the voltage generation circuit 19 is controlled by the operation switch 21 and the like, and generation of a high voltage is controlled. Further, the voltage generation circuit 19 may be provided with a switch for adjusting the magnitude of the voltage or changing the polarity.

The electrode contact member 20 has a tapered needle shape in the application direction in order to concentrate the application of a high voltage at the voltage application electrode 12. As the voltage application electrode 12, for example, a stainless steel electrode is preferably used. The electrode contact member 20 may be a general electric contactor gold-plated contact probe.
The main body side contact 6 is provided on the side surface 7 a of the case body 7 so as to be exposed to the outside of the case body 7, and is electrically connected to the negative side of the battery of the voltage generation circuit 19.

Further, for example, a high resistance circuit or an overcurrent detection circuit (not shown) is incorporated in the voltage generation circuit 19 as a high voltage safety measure. As a high resistance circuit, a high resistance for protection that prevents sparks and electric shock to the living body is arranged in series on the electrode contact member 20. The overcurrent detection circuit detects a current that flows when the voltage generation circuit 19 supplies a high voltage to the voltage application electrode 12, and when the current value exceeds a preset value, the voltage generation circuit 19 is stopped and the generation of the high voltage is stopped. In consideration of safety to the living body of the subject or the like, it is preferable that the set value in the overcurrent detection circuit is set to about 100 μA or less, or at least about 10 μA or less.
The high voltage safety measures need not be limited to the above. For example, the voltage generation circuit 19 may be provided with a detection sensor (not shown) that stops high voltage generation when the anesthetic D in the syringe 11 runs out. . In other words, the voltage generation circuit 19 may generate and supply a high voltage only when the anesthetic D is being fed to the spray nozzle 10.

  The voltage application electrode 12 is an electrode that applies a high voltage supplied from the voltage generation circuit 19 via the electrode contact member 20 to the anesthetic D in the spray nozzle 10. Specifically, the voltage application electrode 12 has a circular tube shape having an inner diameter substantially the same as the inner diameter of the spray nozzle 10, and a through hole 12 a for feeding the anesthetic D is formed therein. Thereby, the voltage application electrode 12 is comprised so that the anesthetic D may be contacted electrically. Further, each end of the voltage application electrode 12 is firmly joined to the distal end of the cylinder member 14 and the proximal end of the spray nozzle 10 by, for example, an adhesive (not shown) so as to ensure watertightness. As a material for forming the voltage application electrode 12, a conductive metal, a conductive resin, a resin on which a conductive film is formed, or the like can be used. For example, a corrosion-resistant stainless steel material can be preferably used. .

  The voltage application electrode 12 applies a high voltage to the anesthetic D near the spray port 9 through the anesthetic D in the spray nozzle 10 when the anesthetic D in the spray nozzle 10 contacts the through hole 12a. Thereby, the anesthetic D is sprayed from the spraying port 9 as charged and atomized fine particles (liquid fine particles). At that time, when the high voltage is positive polarity, the liquid fine particles are charged to positive polarity, and when the high voltage is negative polarity, the liquid fine particles are charged to negative polarity.

  As described above, the cylinder member 14 is filled with the anesthetic agent D, the voltage generation circuit 19 in the voltage application unit 5 generates a high voltage, and the voltage application electrode 20 applies the high voltage to the anesthetic agent D. Thereby, the anesthetic D to which a high voltage is applied is sprayed as charged liquid fine particles. Thus, the cylinder member 14 and the voltage application unit 5 are also a generation unit that generates charged liquid fine particles from the anesthetic D to which a high voltage is applied.

As shown in FIG. 4, the mouthpiece 2 has a mouthpiece body 2a having an elliptical shape extending in a direction orthogonal to the elliptical shape, and radial directions from both axial ends of the mouthpiece body 2a. It is comprised by the hook-shaped positioning part 2b, 2c each formed so that it might protrude outside.
The mouthpiece body 2a is inserted through the tube body 10 to guide the chemical flowing through the tube body from one opening 25a provided at one end to the other opening 25b provided at the other end. A supply hole 25 is formed. Further, in the present embodiment, as shown in FIG. 2, the mouthpiece 2 is formed with an insertion hole 26 that is inserted through the insertion portion E2 of the endoscope E1 and guides the insertion portion E2 into the oral cavity of the subject. Has been. When the insertion portion E2 of the endoscope E1 passes through the insertion hole 26, the insertion portion E2 is in sliding contact with the inner peripheral surface of the insertion hole 26 and is guided in a state along the inner peripheral surface of the insertion hole 26. It will be sent into the oral cavity.
Returning to FIG. 4, the supply hole 25 and the insertion hole 26 are respectively formed along the axis of the mouthpiece body 2 a. And as shown in FIG.4 (b), the opening of the insertion hole 26 which is a comparatively large hole is compared with the substantially center part in the side surface (one end part) by the side of the positioning part 2b of the mouthpiece main-body part 2a. An opening (one opening) 25a of the supply hole 25, which is a relatively small hole, is configured to be located in the periphery.
The inner diameter of the supply hole 25 is set to be substantially equal to the outer diameter of the spray nozzle 10. Thereby, the spray nozzle 10 is inserted through the supply hole 25 and attached.

  In the present embodiment, the entire mouthpiece 2 is formed of a conductive material, and the entire mouthpiece 2 is electrically connected to the mouth H1 when held in a hole such as the mouth H1 of a living body. It is formed by the electric conduction part which takes. When the side surface 7a of the case body 7 is brought into contact with the peripheral edge of the opening 25a of the supply hole 25, the main body side contact 6 is arranged so as to contact the side surface of the mouthpiece 2 on the positioning portion 2b side. Yes.

The mouthpiece 2 is rigid enough to withstand the bite of the subject's teeth H2, such as chemical-resistant stainless steel, titanium alloy, medical plastic (polysulfone, polymethylpentene, TPX, etc.), silver powder or carbon. It is formed of a resin material containing fibers and graphite.
Then, as shown in FIG. 2, the mouthpiece 2 is held in the mouth H <b> 1 of the subject, and the side surface 7 a of the case body 7 is opened in the supply hole 25 in a state where the spray nozzle 10 is inserted into the supply hole 25. An opening provided at the other end opposite to the opening 25a provided at one end of the supply hole 25 when the abutment is brought into contact with the peripheral edge of 25a (the other opening) It is arranged at the position 25b. Accordingly, the spray port 9 is positioned with respect to the mouthpiece 2 and the throat T in the oral cavity, and the spray port 9 is arranged at a position facing the throat T in the oral cavity.

Next, the usage method of the chemical | medical solution spraying apparatus 1 is demonstrated as mentioned above.
Before the use of the chemical spraying device 1 is started, the operation switch 21 is stopped.
First, a desired amount of anesthetic D is filled into the cylinder member 14 of the spray nozzle 10, the voltage application electrode 12, and the cylinder member 14, and the piston member 15 is attached to the cylinder member 14. Then, the spray nozzle 10, the voltage application electrode 12, and the syringe 11 are integrated, and a lid (not shown) is opened and attached to the case body 6 from an opening (not shown).
Next, the mouthpiece 2 is held in the mouth H1 of the subject. Then, the spray nozzle 10 is inserted into the supply hole 25, and the apparatus body 3 is mounted on the mouthpiece 2 with the side surface 7 a of the case body 7 being in contact with the peripheral edge of the opening 25 a of the supply hole 25. At this time, the main body side contact 6 abuts on the mouthpiece 2 and the spray port 9 is arranged at a position facing the throat T in the oral cavity.
When the main body side contact 6 abuts on the mouthpiece 2, the mouth H <b> 1 located in the vicinity of the oral cavity is electrically connected to the negative side of the battery of the voltage generation circuit 19 via the mouthpiece 2, and the voltage generation circuit 19. This is the same potential as the negative side.

Next, by pushing the piston member 15 into the cylinder member 14, the anesthetic D filled in the cylinder member 14 is supplied to the spray port 9 through the voltage application electrode 12 and the spray nozzle 10 and supplied. .
When the operation switch 21 is brought into an operating state when the piston member 15 is pushed in, the high voltage generated from the voltage generation circuit 19 is supplied to the voltage application electrode 12 through the electrode contact member 20. This high voltage is applied to the anesthetic D in the spray nozzle 10 by the voltage application electrode 12. That is, a high voltage is applied to the anesthetic agent D in the spray nozzle 10.

The anesthetic D at the spray port 9 forms an interface between the liquid and the gas with the outside air. When a voltage acts on this interface, the interface becomes unstable electrohydrodynamically due to the electrostatic force acting on the surface of the anesthetic D, and an unstable point is generated. The atomized liquid fine particles charged from this unstable point are sprayed. When a high voltage acts on the interface and the charge density at the interface at the spray port 9 reaches a critical value, a thin liquid thread is drawn from the surface of the anesthetic D, and the liquid thread expands and contracts further.
At this time, the anesthetic D is split from the thin liquid yarn as a large number of liquid fine particles from the tip of the liquid yarn. Further, when the value of the high voltage is increased, the interface in the thin liquid yarn becomes more unstable, and a large number of unstable points are generated simultaneously. From these unstable points, the anesthetic D is sprayed in large numbers from the spray port 9 as charged and completely atomized liquid fine particles.

Then, the anesthetic D to which a high voltage is applied is sprayed from the spray port 9 as atomized charged fine liquid particles and administered to the throat T in the oral cavity.
Note that the diameter of the liquid fine particles of the anesthetic D can be changed by changing the magnitude of the voltage applied by the voltage generation circuit 19.
Next, the insertion part E2 of the endoscope E1 is inserted through the insertion hole 26 of the mouthpiece 2, and the throat T in the oral cavity is observed.

Thus, according to the chemical spray apparatus 1 of the first embodiment of the present invention, when the apparatus main body 3 is attached to the mouthpiece 2 held in the mouth H1 of the subject, the main body side contact 6 and the mouthpiece 2 are connected. Thus, the mouth portion H1 located in the vicinity of the oral cavity to which the anesthetic D is administered is electrically connected to the negative side of the battery of the voltage generation circuit 19. For this reason, the potential difference between the voltage generation circuit 19 of the voltage application unit 5 and the oral cavity can be stabilized and kept constant, and the anesthetic D that is charged and sprayed by the voltage application unit 5 can be used as the anesthetic D and the oral cavity. Can be reliably attached to the throat T in the oral cavity.
Moreover, the mouth part H1 and the voltage application part 5 can be electrically connected easily and reliably only by hold | maintaining the mouthpiece 2 with which the apparatus main body 3 was mounted | worn in the mouth part H1.

Further, when the apparatus main body 3 is attached to the mouthpiece 2 by bringing the side surface 7a of the case body 7 into contact with the peripheral edge of the opening 25a of the supply hole 25, the main body side contact 6 contacts the mouthpiece 2, The spray nozzle 9 is positioned with respect to the mouthpiece 2 by restricting the length of the spray nozzle 10 inserted into the supply hole 25.
Since the mouthpiece 2 is held in the mouth portion H1 of a living body such as a subject, the position of the spray port 9 can be positioned with respect to the oral cavity. For this reason, by pushing the piston member 15 into the cylinder member 14 of the syringe 11, the anesthetic D can be sprayed with its position stabilized in the oral cavity.

More specifically, as shown in FIG. 2, when a high voltage is applied to the anesthetic D, a potential difference is generated between the anesthetic D at the spray port 9 and the throat T in the oral cavity. That is, the voltage generation circuit 19 generates a high voltage and applies a high voltage to the anesthetic D, thereby generating a potential difference between the anesthetic D in the spray port 9 and the throat T in the oral cavity. At this time, electric lines of force L are formed from the spray port 9 toward the throat T in the oral cavity.
The above-mentioned liquid fine particles that have been sprayed and charged follow the electric lines of force L from the spray port 9 and are portions having a different potential from the anesthetic D in the spray port 9 and are within the range where the electric lines of force L are formed. Is selectively administered toward the throat T in the oral cavity. At that time, the charged liquid fine particles adhere to the throat T in the oral cavity having a potential of 0V. That is, the anesthetic D is selectively administered as liquid fine particles only in the throat T of the oral cavity, which is a site having a different electric potential from the anesthetic D in the spray port 9, in other words, only in the target site.

FIG. 5A schematically shows the spray state when the negative side of the voltage generation circuit 19 of the chemical spray device 1 of the present embodiment is connected to the mouthpiece 2 and the oral cavity of the subject is 0 V, and FIG. As a comparative example, b) schematically shows a spray state when the negative side of the voltage generation circuit 19 is not connected to the mouthpiece 2 and the subject's oral cavity is charged to the positive side.
In both FIG. 5 (a) and FIG. 5 (b), a high voltage acts on the anesthetic D of the spray port 9, and many electric lines of force L are formed toward the oral cavity. However, as shown in FIG. 5B, if the oral cavity is not connected to the negative side of the voltage generation circuit 19, the spread of the electric lines of force L is weak. On the other hand, as shown in FIG. 5 (a), when the oral cavity is connected to the negative side of the voltage generation circuit 19, the electric field lines L spread widely, and the liquid fine particles of the charged anesthetic D are strongly attracted. A strong electrical attractive force can be generated.

The surface state of the living body is easily charged to either polarity depending on the charged state in the air or the material of the clothes being worn, and this affects the adhesion of the liquid fine particles of the charged anesthetic D. . In the present embodiment, it is possible to positively set the oral cavity to a potential of 0 V using the mouthpiece 2 that is the closest part to the oral cavity. Therefore, the anesthetic D can be reliably adhered to the oral cavity without being affected by the external environment described above.
In addition, the present embodiment can prevent a positive polarity side potential or a unipolar side potential due to the subject himself / herself receiving charged liquid fine particles, and can improve safety.

Further, by holding the mouthpiece 2 in the mouth H1 of the subject, the supply hole 25 defines the direction of the throat T (to define the direction of the throat T), so that the spray nozzle 10 to be inserted is The throat T can always be placed opposite to the throat T. That is, the anesthetic D can be easily introduced into the oral cavity of the subject by inserting the spray nozzle 10 into the supply hole 25 of the mouthpiece 2. Moreover, it is not necessary to care about the position of the spray nozzle 10 in the oral cavity, and variation in administration position can be suppressed.
Furthermore, in the present embodiment, the position of the mouth 9 of the spray nozzle 10 in the oral cavity can be defined by bringing the peripheral edge of the opening 25a of the supply hole 25 of the mouthpiece 2 into contact with the side surface 7a of the case body 7. . The position of the spray port 9 of the spray nozzle 10 is constant in the oral cavity, and the interval between the spray port 9 and the throat T to be administered is maintained constant. This contributes to making the formation shape (spread shape) of the electric lines of force L formed between the vicinity of the spray port 9 and the throat T close to a constant value, in other words, the electric force lines forming region in the throat T, in other words. Thus, the anesthetic administration region can be made a certain area.
Therefore, the anesthetic agent D can always be sprayed on the surface of a certain region aiming at the throat T, and the variation in the position to be administered by the operator can be reduced as much as possible. In other words, it can be sprayed to the same place every time, regardless of the operator, on the site where anesthesia is required.

  Thus, this embodiment has little dispersion | variation in the throat T in the oral cavity irrespective of gas pressure, and can always administer the anesthetic D stably. In the present embodiment, since the liquid fine particles are charged, the liquid fine particles can be reliably attached only to the throat T in the oral cavity without causing the liquid fine particles to rise. Thereby, this embodiment can administer the anesthetic D reliably to the throat part T which the insertion part E2 of the endoscope E1 contacts, reduces the burden given to a test subject, and observes the inside of a hole part with the endoscope E1. Can do.

In the present embodiment, the anesthetic D is not atomized in the cylinder member 14 or the spray nozzle 10, or the anesthetic D is atomized and is not supplied to the spray port 9. No gas pressure is used to administer D to the throat T.
That is, in this embodiment, the anesthetic D is filled in the spray nozzle 10, the anesthetic D is atomized at the spray port 9, and is administered to the throat T according to the electric lines of force L. Therefore, in this embodiment, the anesthetic agent D is not diffused and floated by the gas pressure, and the liquid dose of the anesthetic agent D adheres to the site to be anesthetized due to the electric strong adsorption action, and the amount to be administered decreases. Can be prevented. Moreover, this embodiment can also prevent that the anesthetic D hangs down from the spray port 9 and adheres to parts other than the throat T. Therefore, this embodiment can selectively administer the anesthetic D to the throat T in the oral cavity.

  Anesthetic D may contain components that solidify after drying. For example, in the principle of ultrasonic atomization used for nebulizers and the like, solidified substances obstruct the propagation of ultrasonic waves, so that atomization often stops. For the ultrasonic atomization principle, for example, a mesh having a hole diameter of several μm is used in order to refine the liquid fine particles. However, when the anesthetic containing the solidified component is atomized, the atomization stops when the mesh is clogged. However, since the present embodiment uses a high voltage without using ultrasonic waves or meshes, it is possible to easily spray completely atomized liquid fine particles that have been charged to some extent with a solid component of some size.

Moreover, the electrical conductivity of the anesthetic D is generally about 70 to 150 μS / cm, and the diameter of the liquid fine particles can be made variable by changing the magnitude of the applied voltage by the voltage generation circuit 19 which is a voltage generation unit. it can. For example, in this embodiment, the diameter of the liquid fine particles can be reduced by increasing the voltage applied by the voltage generation circuit 19.
Thereby, this embodiment can select the optimal diameter of the liquid fine particles. When administered to the throat T, a relatively large liquid particle diameter is considered desirable in order to reduce inflow into the lung. For example, the diameter of the spray port 9 is approximately 0.1 mm and the applied voltage is approximately +5 kV. In this case, liquid fine particles having a diameter of about 50 μm or more can be selectively administered to the throat T. If there is a concern about inflow into the lung, it is considered better not to generate a liquid particle size of 10 μm or less.

  In the present embodiment, it is needless to say that the dose of the anesthetic D per unit time can be increased by increasing the amount of the anesthetic D fed from the syringe 11.

  For example, when the liquid fine particles are not charged, the liquid fine particles are subjected to a force for maintaining a spherical shape by the surface tension of the liquid fine particles. This force becomes stronger as the diameter of the liquid fine particles is smaller. Therefore, if the liquid microparticles are not charged, the liquid microparticles are liable to cause a dry fog phenomenon that does not adhere to the surface of the throat T in the oral cavity, floats in the oral cavity, and is formed in the mouthpiece 2 together with the exhalation. It is discharged out of the living body through the hole. When anesthetic D is administered, the dose is an item that should be managed as accurately as possible. For this reason, in the present embodiment, the liquid fine particles are charged, overcome the exhalation, and are electrically and positively attached to the surface of the throat T. Thereby, this embodiment can selectively administer the anesthetic D to the throat T, and it is easy to manage the dose to the throat T.

Moreover, this embodiment can reduce the administration area of the anesthetic D by bringing the spray port 9 of the spray nozzle 10 close to the throat T, and the spray nozzle 9 is retracted along the insertion direction so that the spray port 9 is moved to the throat T. It is possible to increase the administration area of the anesthetic agent D by separating from the above.
Moreover, in this embodiment, even when two or more types of anesthetics D, a dye chemical solution, and the like are administered, the syringe 11 and various voltages filled with various chemical solutions while the mouthpiece 2 is held in the mouth H1. Only the application electrode 12 and the spray nozzle 10 can be exchanged, and a chemical solution such as a different anesthetic D can be selected and administered to the throat T.

Generally, an electrostatic spray nozzle used for painting or the like is made of metal, and the nozzle itself serves as a voltage application electrode to apply a voltage to the spray nozzle. In this embodiment, in order to apply to a living body, a spray nozzle 10 made of a non-conductive material is used instead of an electrostatic spray nozzle, and the voltage application electrode 12 and the spray port 9 of the spray nozzle 10 are placed at different positions. In spite of the arrangement, the charged fine liquid particles can be sprayed from the spray port 9 and the voltage applying electrode 12 can be kept away from the living body, and the voltage does not act on the living body, which is safe.
Moreover, since this embodiment uses an electric field for spraying from the spraying port 9, the power consumption of the power source 18 for adhering liquid fine particles can be reduced. Furthermore, the high voltage is not applied to the anesthetic D as a direct current component, but a plurality of short pulses are applied (for example, applied at a pulse width of 1 msec and 10 Hz), thereby further reducing power consumption in the power supply 18. Can be made.

(Second Embodiment)
Next, a second embodiment according to the present invention will be described. The same parts as those in the first embodiment are denoted by the same reference numerals, the description thereof will be omitted, and only different points will be described.
As shown in FIGS. 6A and 6B, in the chemical spraying device 31 of the present embodiment, the electric conduction portion 33 is provided on the outer surface of the positioning portion 2 b of the mouthpiece 32.
The electrical conductive portion 33 is set so as to contact, for example, the upper lip when the mouthpiece 32 is held by the mouth portion H1, and is formed of a conductive material such as a metal foil (stainless steel or titanium alloy). ing. The mouthpiece body 2a and the positioning parts 2b, 2c are integrally formed of medical plastic (polysulfone, polymethylpentene, TPX, etc.).

In the chemical spraying device 31 configured as described above, when the device main body 3 is attached to the mouthpiece 32, the main body side contact 6 is in electrical contact with the electric conduction portion 33, the oral inner surface is at 0V potential, and the anesthetic agent The liquid fine particles of D can be firmly adsorbed.
According to the chemical spraying device 31 of the present embodiment, the same effects as those of the above embodiment can be obtained, and the volume of the electric conduction portion 33 can be reduced and the size can be reduced. In other words, the shape of the electric conduction portion 33 is not limited as long as the mouth portion H1 and the main body side contact 6 are electrically connected, and the desired effect can be achieved.
The electrically conductive portion 33 may be formed not on a metal foil but on a part of or the entire surface of the mouthpiece main body portion 2a and the positioning portions 2b and 2c by a vacuum deposition method or a sputtering method.
Moreover, in the mouthpiece 32 of this embodiment, the electric conduction part 33 can be provided later on the outer surface of the positioning part 2b already formed.

(Third embodiment)
Next, a third embodiment according to the present invention will be described. The same parts as those of the above embodiment are denoted by the same reference numerals, the description thereof will be omitted, and only different points will be described.
As shown in FIG. 7, in the chemical spray apparatus 41 of the present embodiment, a conductive layer 44 is provided on the outer surface of the spray nozzle 10, and when the spray nozzle 10 is inserted through the supply hole 25, the conductive layer 44. Is configured to slidably contact the inner peripheral surface of the supply hole 25.
The spray nozzle 10 is made of, for example, a non-conductive material made of tetrafluoroethylene resin and has flexible flexibility and insulation, and the conductive layer 44 provided on the outer surface of the spray nozzle 10 is exposed. ing. The conductive layer 44 is electrically connected to the negative side of the battery of the voltage generation circuit 19.
Examples of such an insulating spray nozzle 10 having a conductive layer 44 on the outer surface include TOMBO (registered trademark) No. 9003-PFA-NE (trade name; manufactured by Nichias Corporation, Naflon (registered trademark) PFA-NE tube) and the like can be used.
In the present embodiment, the entire mouthpiece 2 is formed of a conductive material, and the entire mouthpiece 2 is electrically connected to the mouth H1 when held by the mouth H1 of the living body. It is an electric conduction part.
In the present embodiment, the inner diameter of the supply hole 25 is set to be substantially equal to the outer diameter of the conductive layer 44.

  According to the chemical spraying device 41 of the present embodiment, the same effects as in the above embodiment can be obtained. Further, by inserting the tube body 10 through the supply hole 25 formed in the mouthpiece 2, the conductive layer 44 provided on the outer surface of the spray nozzle 10 is slidably contacted with the inner peripheral surface of the supply hole 25, Electrical conduction between the voltage generating circuit 19 and the mouthpiece 2 can be established.

More specifically, the inner peripheral surface of the spray nozzle 10 is electrically insulated because the anesthetic agent D to which a high voltage is applied is fed. Since the conductive layer 44 is formed on the outer surface and is connected to the negative side of the battery of the voltage generation circuit 19, the contact with the supply hole 25 of the mouthpiece 2 formed of a conductive material is utilized. The surface in the oral cavity can be set to 0V.
Also in the present embodiment, a strong electrical adsorption action can be exhibited, and the liquid fine particles of the anesthetic agent D can be adhered to the surface in the oral cavity without being lifted up.

  In addition, depending on the material constituting the spray nozzle 10 due to application of a high voltage to the anesthetic, a charging phenomenon due to a polarization action may appear on the material surface of the spray nozzle 10. Due to this, the formation of electric lines of force L from the spray port 9 may be affected. In the present embodiment, the charged charges on the material surface of these spray nozzles 10 can also be returned to the negative side of the battery of the voltage generation circuit 19 using the conductive layer 44, so that a more stable and strong electric field line L can be obtained. And the liquid fine particles of the anesthetic D can be reliably attached to the living body surface in the oral cavity. Therefore, the anesthetic D can be reliably administered to the throat T, and the burden when the endoscope E1 is inserted can be reduced.

As mentioned above, although 1st Embodiment and 2nd Embodiment of this invention were explained in full detail with reference to drawings, the concrete structure is not restricted to this embodiment, The structure of the range which does not deviate from the summary of this invention Changes are also included.
For example, in the chemical spraying apparatus of the first to third embodiments, the anesthetic D is administered into the oral cavity while the mouthpiece is held in the mouth H1. However, a cylindrical holding member may be attached to the opening of the nostril, and the spray nozzle 10 may be inserted through a supply hole formed in the holding member. Alternatively, the holding member may be held in the ear hole and the spray nozzle 10 may be inserted.

Moreover, in the chemical | medical solution spraying apparatus of the said 1st Embodiment and 3rd Embodiment, although it decided to arrange the spraying opening 9 of the spraying nozzle 10 in the position of the other opening 25b of the hole 25 for supply, it replaces with this. The spray nozzle 10 has such a length that when the spray nozzle 10 is inserted through the supply hole 25, the spray port 9 protrudes to the throat T side in the oral cavity from the other opening 25 b of the supply hole 25. Also good. Further, in this case, with the spray nozzle 10 inserted through the supply hole 25, the side surface 7 a of the case body 7 is brought into contact with the peripheral edge of one opening 25 a of the supply hole 25, thereby May be configured to be positioned relative to the throat T in the oral cavity.
Further, in the chemical spraying apparatus of the first to third embodiments, the supply hole 25 and the insertion hole 26 may be communicated with each other in the mouthpiece body 2a. A supply hole 25 may be formed in part.

Moreover, in the chemical | medical solution spraying apparatus of the said 1st Embodiment and 3rd Embodiment, although the spray port 9 was attached to the front-end | tip part of the spray nozzle 10, it replaces with this and the other of the supply hole 25 is used. May be provided on the opening 25b side. Here, the tip of the spray nozzle 10 may be disposed inside the supply hole 25 without being projected from the supply hole 25 or connected to one opening 25 a of the supply hole 25. In this case, a chemical solution such as anesthetic D is sprayed from the other opening 25 b of the supply hole 25.
Further, in the chemical spraying apparatus of the first embodiment and the third embodiment, the insertion hole 26 is formed in the mouthpiece 2. However, when the anesthetic D is simply administered without being inserted through the insertion portion E2 of the endoscope E1, the insertion hole 26 may not be formed.
Moreover, the chemical | medical solution spraying apparatus of the said 1st Embodiment and 3rd Embodiment is good also as being applied to an animal as a biological body.

1, 31, 41 Chemical spraying device 2, 32 Mouthpiece (holding member)
3 Device body 4 Chemical solution supply unit 5 Voltage application unit 6 Body side contact (ground)
7a Side (Regulatory part)
9 Spray port (spray hole)
10 Spray nozzle (tube body)
11 Syringe 14 Cylinder member 15 Piston member 25 Supply hole 25a Opening (one opening)
26 Insertion hole 33 Electric conduction part 44 Conductive layer D Anesthetic (chemical)
E1 endoscope E2 insertion part H1 mouth

Claims (6)

A chemical spray apparatus for spraying and administering a chemical solution to a target site inside a living body,
A holding member held in a state of being positioned with respect to the target site;
A supply hole provided in the holding member, for guiding the chemical liquid from one end to the other end;
A chemical solution supply unit attached to the supply hole and supplying the chemical solution to the supply hole;
A spray port for spraying the chemical solution supplied to the supply hole;
A voltage application unit for applying a voltage to the chemical solution;
A ground part electrically connected to the voltage application part;
An electrically conductive part electrically connected to the ground part and having conductivity at least part of the outer surface of the holding member;
With
A chemical liquid spraying apparatus, wherein the chemical liquid is sprayed in a mist form from the spray port toward a portion in the living body that is different from the potential of the chemical liquid in the spray port in a state where the chemical solution is charged by the voltage application unit. In the chemical spray apparatus according to claim 1,
A case body that accommodates at least a part of the chemical solution supply unit and the voltage application unit,
The chemical spraying device according to claim 1, wherein the ground portion is disposed on the case body so as to contact the electric conduction portion. In the chemical spraying device according to claim 2,
The chemical solution supply unit has a tube body provided with the spray port at a tip part,
The case body has a restricting portion that restricts the length of the tube body inserted into the supply hole by contacting the peripheral edge of one opening of the supply hole,
The chemical spraying device according to claim 1, wherein the ground portion is disposed so as to contact the electric conduction portion when the regulating portion is brought into contact with a peripheral portion of the one opening. In the chemical spray apparatus according to claim 1,
The chemical solution supply unit has a tube body formed of an insulating material provided with the spray port at a distal end portion.
The ground part is provided on the outer surface of the tube body, and has a conductive layer electrically connected to the voltage application part,
The chemical spraying apparatus, wherein the conductive layer is configured to be in sliding contact with an inner peripheral surface of the supply hole when the tube body is inserted into the supply hole. In the chemical spraying device according to any one of claims 2 to 4,
The chemical spraying device according to claim 1, wherein the electrical conductive portion is a conductive material forming the holding member. In the chemical spraying device according to any one of claims 1 to 5,
An insertion hole for inserting an insertion portion of an endoscope and guiding the insertion portion into a living body is formed in the holding member.

Images