JP2010208896A5 - - Google Patents
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- JP2010208896A5 JP2010208896A5 JP2009057161A JP2009057161A JP2010208896A5 JP 2010208896 A5 JP2010208896 A5 JP 2010208896A5 JP 2009057161 A JP2009057161 A JP 2009057161A JP 2009057161 A JP2009057161 A JP 2009057161A JP 2010208896 A5 JP2010208896 A5 JP 2010208896A5
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本発明の板状ＨＡｐ単結晶の製造方法において、前記酸性水溶液中のＣａ２＋イオンの濃度を０．００２５〜０．０１００ｍｏｌ・ｄｍ−３の範囲とし、ＰＯ４ ３−イオンの濃度を０．００１５〜０．００６０ｍｏｌ・ｄｍ−３の範囲とし、尿素の濃度を０．５〜２．０ｍｏｌ・ｄｍ−３の範囲とし、ウレアーゼの濃度を前記尿素１当量に対して０．２倍当量から３倍当量の範囲とすることが好ましい。 In the method for producing a plate-like HAp single crystal of the present invention, the concentration of Ca 2+ ions in the acidic aqueous solution is in the range of 0.0025 to 0.0100 mol · dm −3 , and the concentration of PO 4 3- ions is 0.0015. The range of ˜0.0060 mol · dm −3 , the concentration of urea in the range of 0.5 to 2.0 mol · dm −3 , and the urease concentration from 0.2 to 3 times the equivalent of 1 urea. It is preferable to be in the range of equivalents.
前記工程（１）において、酸性水溶液の調製は、Ｃａ化合物（Ｃａ ２＋ イオン）とＰ化合物（ＰＯ ４ ３− イオン）とをＨＡｐの合成に好適なモル比（例えば、Ｃａ／Ｐ＝１．６７）となるように秤量、採取し、尿素と共に精製水に加えて混合し、この水中に硝酸や塩酸などの無機酸、あるいは酢酸、クエン酸、乳酸などの有機酸を加え、ｐＨを酸性側にしてＣａ化合物、Ｐ化合物及び尿素を溶解させ、その後、適当量のウレアーゼを加えて調製することが好ましい。 In the step (1), the acidic aqueous solution is prepared by mixing a Ca compound (Ca 2+ ion) and a P compound (PO 4 3- ion) in a molar ratio suitable for the synthesis of HAp (for example, Ca / P = 1.67). ) And weighed and collected with urea and mixed with purified water and mixed with inorganic acid such as nitric acid and hydrochloric acid, or organic acid such as acetic acid, citric acid and lactic acid in this water to make the pH acidic. It is preferable to prepare by dissolving Ca compound, P compound and urea, and then adding an appropriate amount of urease.
図５には水熱処理後のＮｏ．１〜Ｎｏ．４の界面の析出物のＳＥＭ画像を示す。Ｃａ２＋，ＰＯ４ ３−濃度が低い場合（Ｎｏ．１，Ｎｏ．２）生成物の形態が処理前と比べて多少崩れるが、板状である（ａ軸配向）ことが確認できた。また、Ｃａ２＋，ＰＯ４ ３−濃度が高い場合（Ｎｏ．３，Ｎｏ．４）、生成物は板状のものではなく、短冊状の形態（ｃ軸配向）となった。ＳＥＭにより観察された生成物の特異的な配向性は、図４のＸＲＤの結果と一致している。 FIG. 5 shows No. after hydrothermal treatment. 1-No. The SEM image of the deposit of the interface of 4 is shown. When the Ca 2+ and PO 4 3− concentrations were low (No. 1, No. 2), the form of the product was slightly collapsed compared with that before the treatment, but it was confirmed that it was plate-like (a-axis orientation). Further, when Ca 2+, is PO 4 3- concentration is high (No.3, No.4), the product is not plate-shaped, has a rectangular form (c-axis orientation). Specific orientation of the products observed by SEM is consistent with the results of XRD of Figure 4.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009057161A JP5467432B2 (en) | 2009-03-10 | 2009-03-10 | Method for producing plate-like hydroxyapatite single crystal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009057161A JP5467432B2 (en) | 2009-03-10 | 2009-03-10 | Method for producing plate-like hydroxyapatite single crystal |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010208896A JP2010208896A (en) | 2010-09-24 |
| JP2010208896A5 true JP2010208896A5 (en) | 2012-03-29 |
| JP5467432B2 JP5467432B2 (en) | 2014-04-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009057161A Expired - Fee Related JP5467432B2 (en) | 2009-03-10 | 2009-03-10 | Method for producing plate-like hydroxyapatite single crystal |
Country Status (1)
| Country | Link |
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| JP (1) | JP5467432B2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105000540B (en) * | 2015-06-14 | 2019-01-15 | 青岛科技大学 | A kind of preparation method of overlength hydroxyapatite micro-/ nano band |
| JP7137816B2 (en) * | 2017-04-27 | 2022-09-15 | 国立研究開発法人産業技術総合研究所 | Adsorbent that selectively adsorbs substances with basic sites |
| EP4212478A1 (en) | 2018-12-27 | 2023-07-19 | Shiraishi Kogyo Kaisha, Ltd. | Method for producing hydroxyapatite particles |
| WO2020138500A1 (en) | 2018-12-27 | 2020-07-02 | サンスター スイス エスエー | Composition for oral cavity |
| CN109809809A (en) * | 2019-03-07 | 2019-05-28 | 华南理工大学 | A kind of construction method of the hexagonal prisms microarray of hydroxyapatite scaffold apparent height orientation |
| CN114057173B (en) * | 2021-09-13 | 2023-12-15 | 曲阜师范大学 | Method for synthesizing hydroxyapatite with large specific surface area by using seed crystal |
| CN115227719B (en) * | 2022-07-18 | 2024-06-21 | 西南交通大学 | Calcium-phosphorus nanoenzyme with excellent peroxidase activity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4870294B2 (en) * | 2001-09-28 | 2012-02-08 | 守 相澤 | Method for producing plate-like hydroxyapatite particles |
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- 2009-03-10 JP JP2009057161A patent/JP5467432B2/en not_active Expired - Fee Related
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