JP2010155827A5 - - Google Patents
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- Publication number
- JP2010155827A5 JP2010155827A5 JP2009275269A JP2009275269A JP2010155827A5 JP 2010155827 A5 JP2010155827 A5 JP 2010155827A5 JP 2009275269 A JP2009275269 A JP 2009275269A JP 2009275269 A JP2009275269 A JP 2009275269A JP 2010155827 A5 JP2010155827 A5 JP 2010155827A5
- Authority
- JP
- Japan
- Prior art keywords
- substituent
- alkyl group
- group
- compound
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 125000001424 substituent group Chemical group 0.000 claims 21
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- FGRBYDKOBBBPOI-UHFFFAOYSA-N 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one Chemical compound O=C1c2ccccc2S(=O)(=O)c2ccc(cc12)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 FGRBYDKOBBBPOI-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 229940123730 Orexin receptor antagonist Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 108050000742 Orexin Receptor Proteins 0.000 claims 1
- 102000008834 Orexin receptor Human genes 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- -1 phenyl 4-[(4-fluorophenyl) sulfonyl] -1-oxa-4,8-diazaspiro [4.5] decane-8-carboxylate Chemical compound 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009275269A JP2010155827A (ja) | 2008-12-04 | 2009-12-03 | スピロ環化合物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008310301 | 2008-12-04 | ||
JP2009275269A JP2010155827A (ja) | 2008-12-04 | 2009-12-03 | スピロ環化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010155827A JP2010155827A (ja) | 2010-07-15 |
JP2010155827A5 true JP2010155827A5 (US07981874-20110719-C00313.png) | 2013-01-17 |
Family
ID=42574021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009275269A Ceased JP2010155827A (ja) | 2008-12-04 | 2009-12-03 | スピロ環化合物 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2010155827A (US07981874-20110719-C00313.png) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7106659B2 (ja) | 2018-02-13 | 2022-07-26 | 上海 インスティテュート オブ オーガニック ケミストリー、チャイニーズ アカデミー オブ サイエンシーズ | インドール-2、3-ジオキシゲナーゼ阻害剤としてのスピロ化合物 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2506266C2 (ru) * | 2009-01-26 | 2014-02-10 | Израэл Инститьют Фо Байолоджикал Рисерч | Бициклические гетероциклические спиросоединения |
EP2811997B1 (en) | 2012-02-07 | 2018-04-11 | Eolas Therapeutics Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
EP3026054B1 (en) | 2013-07-23 | 2019-03-06 | Eisai R&D Management Co., Ltd. | Hetero-condensed ring compound |
TW201613864A (en) * | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
US10221170B2 (en) | 2014-08-13 | 2019-03-05 | Eolas Therapeutics, Inc. | Difluoropyrrolidines as orexin receptor modulators |
HUE059280T2 (hu) | 2016-02-12 | 2022-11-28 | Astrazeneca Ab | Halogén-szubsztituált piperidinek mint orexin receptor modulátorok |
CN105859726B (zh) * | 2016-05-18 | 2018-07-13 | 南京富润凯德生物医药有限公司 | 一种嘧啶并环中选择性脱卤素的方法 |
MX2022006422A (es) * | 2019-11-27 | 2022-08-25 | Sumitomo Pharma Co Ltd | Derivado de cicloalquilurea. |
WO2022250108A1 (ja) * | 2021-05-26 | 2022-12-01 | 住友ファーマ株式会社 | フェニルウレア誘導体 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1812768A1 (de) * | 1967-12-11 | 1969-07-03 | Yoshitomi Pharmaceutical | Neue Benzodioxanderivate |
AU2006282955A1 (en) * | 2005-08-26 | 2007-03-01 | Merck & Co., Inc. | Diazaspirodecane orexin receptor antagonists |
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2009
- 2009-12-03 JP JP2009275269A patent/JP2010155827A/ja not_active Ceased
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7106659B2 (ja) | 2018-02-13 | 2022-07-26 | 上海 インスティテュート オブ オーガニック ケミストリー、チャイニーズ アカデミー オブ サイエンシーズ | インドール-2、3-ジオキシゲナーゼ阻害剤としてのスピロ化合物 |