JP2010126501A - Magnetism irradiation device, its manufacturing method and device for irradiating magnetism into living body, drug delivery system, tool retainer, and tool retaining method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a magnetism irradiation device having biocompatibility, long-period stability and high degree of design freedom. <P>SOLUTION: The magnetism irradiation device includes a magnet, a space and a sealed casing for holding the magnet in the space. The casing is made of materials that are biocompatible and are not biodegradable. Directivity may be given by applying a shield to a part of the magnet. Suitable materials for the casing include any one of titanium-based materials, ceramics, oxynium and ultrahigh-molecular-weight polyethylene or a combined material of these materials. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a magnetic irradiation apparatus and a manufacturing method thereof. The present invention also relates to an in-vivo magnetic irradiation device using a magnetic irradiation device, a jig fixing device, a jig fixing method, and a drug delivery system.

  Recent advances in medicine are remarkable and new treatment systems are being developed one after another. Among them, a new treatment system using magnetism is attracting attention.

  Patent Document 1 proposes a subject movement state detection system using magnetism. FIG. 11 shows a configuration diagram of a magnetic irradiation apparatus which is an in-subject introduction apparatus described in Patent Document 1. As shown in the figure, the magnetic irradiation apparatus 101 includes a permanent magnet 110, a biocompatible material 130, a shell 150, and a filling member 151. The shell 150 is formed of a flexible material (for example, soft gelatin or biodegradable polymer) that can be deformed by pressurization of a predetermined amount or more from the outside, and the shell 150 stays on the subject for a certain period of time. In such a case, it is configured to be decomposed in response to a body fluid secreted inside the subject. The permanent magnet 110 is coated with a biocompatible material 130. The filling member 151 is filled in the gap between the shell 150 and the permanent magnet 110.

  The magnetic irradiation apparatus 101 configured as described above is introduced from the mouth into the subject and moves inside the body (inside the body cavity) such as the stomach and the small intestine until it is naturally discharged from the living body of the subject. Then, position information is provided by the magnetic force generated from the magnetic irradiation device 101.

  When the magnetic irradiation apparatus 101 is not discharged outside the subject due to narrowing, narrowing, or blocking of the subject's tube, the shell 150 is decomposed by the body fluid as described above. As the filling member 151, a highly safe material is applied, and the permanent magnet 110 is covered with the biocompatible material 130, so that it is not necessary to take them out by laparotomy or the like. This makes it possible to obtain in advance information useful for determining whether or not the capsule endoscope can be safely used for a patient.

  Inventor Namiki recently proposed a strong magnet that can be used inside a living body and has high safety in Patent Document 2. In FIG. 12, the schematic block diagram of the magnetic irradiation apparatus 201 of patent document 2 is shown. The magnetic irradiation device 201 includes an Nd (neodymium) -Fe (iron) -B (boron) magnet 210, a covering member 250 covering the magnet 210, an exterior member 230, and the like.

The covering member 250 is configured by plating of pure gold or pure platinum, which is relatively high in biocompatibility and has excellent adhesion to the magnet surface and Ti (titanium) -based material. The exterior member 230 is configured by plating a Ti-based material such as Ti, TiN (titanium nitride), and TiC (titanium carbide) that has extremely high biocompatibility and excellent corrosion resistance. Thereby, the expression of carcinogenicity, metal allergy, etc. which have been caused by conventional Ni (nickel), Cu (copper) and the like can be prevented.
JP 2008-183451 A Registered Utility Model No. 3142031

  If long-term stability of the magnetic irradiation device can be realized, further application development can be expected in the development of a new treatment system using magnetism. In addition, it is ideal to provide a magnetic irradiation device with a high degree of design freedom in accordance with the treatment site and treatment needs.

  The present invention has been made in view of the above background, and an object of the present invention is to provide a magnetic irradiation device having both biocompatibility and long-term stability and high design flexibility.

  A magnetic irradiation apparatus according to the present invention includes a magnet and a casing that is sealed by accommodating the magnet in the gap, and the casing is biocompatible and biodegradable. It is composed of no material.

  In Patent Document 2, it is necessary to provide an electrode for energization on a part of the magnet in order to perform the plating process. Moreover, it was necessary to plate the magnet with pure gold or pure platinum, and further with a material excellent in biocompatibility. In the case of using expensive pure gold or pure platinum, high cost is inevitable. Moreover, when it coat | covers by a plating process, it cannot be said that there is long-term stability depending on a use.

  According to the magnetic irradiation apparatus of the present invention, by adopting a structure in which a magnet is accommodated and sealed in a casing made of a material that exhibits biocompatibility and does not exhibit biodegradability, the shape of the magnet is limited. Therefore, it is possible to freely design a casing having an exterior shape. As a result, the casing can be designed according to the application and required characteristics. Moreover, unlike the case where the magnet is plated, the material can be selected independently without considering the compatibility between the magnet and the casing. For this reason, it is easy to widen the range of material options and to provide higher functionality. Furthermore, long-term stability can be imparted by using a material that does not exhibit biodegradability. Thereby, long-term indwelling inside the living body becomes possible, and application development to various medical treatments becomes possible.

  The in-vivo magnetic irradiation apparatus according to the present invention is one in which the magnetic irradiation apparatus is installed in a subject.

  In the drug delivery system according to the present invention, the magnetic irradiation device is installed in an affected area, and a magnetic drug injected into a subject is accumulated in the affected area.

  The jig fixing device according to the present invention is fixed to a subject, a first jig fixing means provided with a first jig, and a second jig fixed provided with a second jig. And the first jig fixing means and the second jig fixing means are each provided with the magnetic irradiation device, and the first jig fixing means by the magnetic force of the magnetic irradiation device. The second jig fixing means is configured to be detachable from each other.

  In the jig fixing method according to the present invention, the first jig is installed, the first jig fixing means including the first magnetic irradiation device is fixed to the subject, and the second jig is installed. The second jig fixing means including the second magnetic irradiation apparatus is bonded to the first jig fixing means by the magnetic force of the first magnetic irradiation apparatus and the second magnetic irradiation apparatus, and the bonding is performed. The jig fixing method in which the first jig and the second jig jointly exert a predetermined function, wherein the first magnetic irradiation device and the second magnetic irradiation device are: The magnetic irradiation apparatus is used.

  The manufacturing method of the magnetic irradiation apparatus according to the first aspect of the present invention is composed of a material that is biocompatible and does not exhibit biodegradability, and encloses and seals a magnet in a casing having a void inside. Thereafter, the magnet is magnetized.

  The manufacturing method of the magnetic irradiation apparatus according to the second aspect of the present invention comprises a magnet that is made of a material that is biocompatible and does not exhibit biodegradability, and is magnetized in a casing having a void inside. Thereafter, the casing is sealed while sufficiently cooling.

  According to the present invention, there is an excellent effect that a magnetic irradiation device having both biocompatibility and long-term stability and having a high degree of design freedom can be provided. As a result, it can be expected to be applied to a wide range of applications such as the development of new treatment systems using magnetism.

  Hereinafter, an example of an embodiment to which the present invention is applied will be described. It goes without saying that other embodiments may also belong to the category of the present invention as long as they match the gist of the present invention. Moreover, the size and ratio of each member in the following drawings are examples, and are not limited to these.

[Embodiment 1]
FIG. 1 is a schematic perspective view showing the appearance of the magnetic irradiation apparatus according to the first embodiment, and FIG. 2 is an exploded perspective view of the magnetic irradiation apparatus according to the first embodiment. 3A shows a perspective view when the lid of the magnetic irradiation device 1 is removed, and FIG. 3B shows a top view thereof. FIG. 3C is a sectional view taken along the line IIIC-IIIC in FIG.

  As shown in FIGS. 1 to 3, the magnetic irradiation device 1 includes a magnet 10, a shield means 20, a housing part 30, a fixed part 31, an engaging part 32, a lid part 40, and the like. The magnet 10 and the shield means 20 function as the magnetic force generation means 2. In addition, the accommodating portion 30, the fixed portion 31, and the lid portion 40 function as the casing 3. The shield means 20 is composed of a magnetic shielding member. Thereby, directivity can be imparted to the magnetic lines of force of the magnet 10.

  In addition, as the magnetic force generation means 2, it is sufficient to have the magnet 10, and when it is not necessary to give directivity to the magnet 10, the shield means 20 may not be provided. Moreover, the casing 3 should just be a form which can accommodate the magnet 10 and can be sealed, and installation of the fixed part 31 is arbitrary. Moreover, you may make it equip the casing 3 with engagement parts, installation parts, etc., such as another jig | tool.

  The type and shape of the magnet 10 are not particularly limited. For example, an electromagnet, a superconducting magnet, or a permanent magnet can be used. It is preferable to use a permanent magnet from the viewpoint of miniaturization of the magnetic irradiation device and easy sealing. The type of the permanent magnet is not particularly limited, but examples thereof include ferrite, Ne—Fe—B alloy, and samarium-cobalt alloy. In the case where a strong magnetic force is required, a Ne—Fe—B alloy is preferable. The shape of the magnet 10 is not particularly limited as long as it can be accommodated in the casing 3 and sealed, but in the first embodiment, a cylindrical body is used as shown in FIG.

  As described above, the shield means 20 has a shield function for imparting directivity to the magnetic field generation direction of the magnet 10. The shield means 20 according to the first embodiment is configured by a yoke (a yoke). Of course, the material is not limited to this as long as it has a shielding function. In the first embodiment, the yoke serving as the shield means 20 is arranged so that a strong magnetic force is generated on the lower side (bottom surface 11) of the cylindrical body in FIG. 2 of the magnet 10 (Y direction in FIG. 2). The cylindrical body has a concave shape that covers the side surface 12 and the upper surface 13 of the magnet 10. By providing the shield means 20, the magnetic force from the lower surface 11 of FIG. 1 of the magnet 10 can be increased, and a significant attenuation of the magnetic force from the upper surface 12 of FIG. 1 can be realized.

  The casing 3 is made of a material that is biocompatible and does not exhibit biodegradability. As long as the material satisfies these conditions, the material is not particularly limited. For example, biocompatible Ti, titanium vanadium alloy (for example, Ti added with 6% aluminum, 4% vanadium), titanium niobium alloy ( Examples thereof include Ti-based materials such as Ti added with 6% aluminum and 7% niobium) and titanium-zirconium alloys. In addition, ceramics such as alumina, silicon nitride, silicon carbide, and zirconia can also be exemplified. Furthermore, oxynium converted into ceramic by heating the metal surface at a high temperature, ultrahigh molecular weight polyethylene (molecular weight of 1.5 million or more (more preferably 4.5 million or more)), and the like can be mentioned.

  When a titanium-based material is applied as the casing 3, the surface thereof is TiN (titanium nitride), TiC (titanium carbide), TiCN (titanium carbonitride), TiAlN (titanium nitride aluminum) or the like by a dry plating method such as ion plating. It is also possible to coat with. Thereby, advanced functions such as wear resistance, oxidation resistance, and corrosion resistance can be added. The casing 3 is not limited to what is comprised only from the same material, You may comprise from several materials. For producing the casing 3, for example, a known method such as cutting or injection molding can be applied.

  The material of the casing 3 is preferably a material having a high elastic modulus from the viewpoint of increasing the mechanical strength. Specifically, in the case of a non-resin, the Young's modulus (elastic modulus) is preferably 30 GPa or more, and more preferably 90 GPa or more. In the case of a resin, the initial flexural modulus (elastic modulus) is preferably 200 MPa or more, and more preferably 600 MPa or more.

  When a titanium-based material is used as the casing 3, when anodization is performed, the color of the exterior can be freely changed while maintaining biocompatibility by changing the thickness of the oxide film (titanium oxide). It is also possible to write letters and symbols by changing the color of part of the exterior by anodic oxidation. That is, it is possible to facilitate identification between a plurality of apparatuses by applying titanium coloring by anodic oxidation.

  Furthermore, when a titanium-based material is used on the surface of the casing 3, an antibacterial function and a self-cleaning function can be imparted. Specifically, when an oxide film formed on the surface of a titanium-based material is irradiated with ultraviolet rays or black light, the organic substance is decomposed by a photocatalytic action and exhibits a strong bactericidal action. At the same time, the water adhering to the device surface due to photohydrophilization spreads uniformly on the surface without forming water droplets, and even under the absence of a surface active agent such as a cleaning agent, it enters under the dirt adhering to the device surface and becomes dirty. Make it easier to drop. For this reason, when a titanium-based material is used on at least the surface of the casing 3, an excellent function is exhibited particularly for medical use.

  The casing 3 according to the first embodiment includes a housing part 30 for the magnet 10, a fixed part 31, and a lid part 40. The accommodating part 30 and the fixed part 31 are integrally formed. The accommodating part 30 and the cover part 40 are comprised separately, and are joined after accommodating the magnet 10. Thereby, the magnetism generating means 2 is sealed inside the casing 3. The accommodating portion 30 is formed with a substantially similar space that can accommodate the cylindrical magnetic generating means 2.

  The fixed portion 31 has a flat disk shape larger than the outer diameter of the accommodating portion 30, and is integrally formed on the bottom surface portion of the accommodating portion 30 so that the concentricity of both is substantially coincident. The fixed portion 31 is a portion that is fixed in contact with the subject or the test object, and includes a through hole 32 that is fixed to the subject as a fixing means. In the through-hole 32, for example, the affected part of the subject and a surgical thread or a surgical staple are fixed. Alternatively, the test object is fixed with bolts and nuts. The lid portion 40 is configured by a circular plate. The material of the accommodating part 30, the fixed part 31, and the cover part 40 may be the same or different as long as the material is highly biocompatible.

  In addition, the example of the fixed part 31 and the through-hole 32 which is a fixing means is an example, Comprising: The installation location in the casing 3, an installation shape, etc. are not limited to this. Further, as described above, the fixed portion 31 and the through hole 32 are not necessarily provided. In other words, when it is not necessary to fix the subject or the test object, the fixing portion 31 or the like need not be provided. Further, even when the casing 3 and the subject or the test object can be directly fixed with an adhesive material or an adhesive, it is not necessary to provide the fixing portion 31 or the like.

  The magnet 10 is sealed by the following procedure. That is, after the magnetic force generating means 2 constituted by the magnet 10 and the shielding means 20 is accommodated in the casing 3, the lid portion 40 is covered. Subsequently, the accommodating part 30 and the cover part 40 are joined by a well-known method. The joining method is not particularly limited as long as the magnetic force generating means 2 can be sealed, but a preferable example is a welding or adhesion method. Among these, in consideration of the continuity at the molecular level of the joining portion, it is more preferable to directly join by welding.

  Examples of the welding include fusion welding such as gas welding, arc welding, electroslag welding, electron beam welding, and laser beam welding. Also, pressure welding such as resistance welding, forging welding, friction welding, or explosion welding may be applied. Alternatively, brazing such as brazing or soldering may be used. Of these, arc welding is preferable in consideration of welding using a biocompatible metal as a base material.

  Examples of the arc welding include non-consumable electrode types such as TIG (Tungsten Inert Gas) welding and plasma welding, or consumable electrode types such as covered arc welding, submerged arc welding, MIG welding, carbon dioxide arc welding, and self-shielding welding. It is done. Among these, considering high-quality welding that is stable for a long time, the non-consumable electrode type is more preferable, and plasma welding is particularly preferable.

  The magnetizing method of the magnet 10 is not particularly limited, and a known method can be applied. For example, a static magnetic field and a pulse magnetic field can be mentioned. When sealing the magnetic force generating means 2 of the casing 3 under high temperature conditions such as welding, it is preferable to seal the non-magnetized magnet 10 to the casing 3 and magnetize the magnet 10 after sealing. This is to prevent the magnet 10 from being greatly damaged by being exposed to a high temperature and reaching the Curie temperature. However, if the cooling of the magnet 10 at the time of sealing accompanied by heating can be sufficiently performed by argon gas spraying or a heat radiating device, it is possible to land before the housing portion 30 and the lid portion 40 are joined.

  The magnetic irradiation apparatus 1 configured as described above generates a large magnetic field line in the lower direction in FIG. 1 as described above.

  Since the magnetic irradiation apparatus 1 according to the first embodiment is made of a material that exhibits biocompatibility and does not exhibit biodegradability, the magnetic irradiation apparatus 1 can be suitably applied to applications that contact or approach a living body. The applicable species are not limited, and a wide range of animals including mammals such as humans, monkeys, cows, sheep, goats, horses, pigs, rabbits, dogs, cats, mice, rats, guinea pigs, etc. Can be applied to. Moreover, it can also apply to a plant, microorganisms, etc., The range is not specifically limited.

  Moreover, it can be suitably used as an in-vivo magnetic irradiation device that is not only in contact with the outside of the living body (for example, skin) but is placed in the living body for a long period of time. When used in vivo, the indwelling site of the magnetic irradiation device is not particularly limited, but as an example, it is intravenous, intraparenchymal organ (for example, brain, eyes, thyroid gland, mammary gland, heart, lung, liver, pancreas, kidney, Adrenal gland, ovary, testis, etc.), intraluminal lumen (eg, esophagus, stomach, duodenum, jejunum, ileum, large intestine, gallbladder, ureter, intravesical, etc.), cerebrospinal cavity, intrathoracic cavity, intraperitoneal cavity , Intramuscular, intraarticular, subcutaneous, intradermal and the like.

  According to the first embodiment, by adopting a structure in which a magnet is accommodated and sealed in a casing made of a material that exhibits biocompatibility and does not exhibit biodegradability, the exterior is not restricted by the shape of the magnet. It becomes possible to design the casing which is a shape freely. As a result, the casing can be designed according to the application and required characteristics. For example, as in the first embodiment, it is possible to provide the casing 3 with a fixed portion with the subject or the test object.

  Moreover, unlike the case where the magnet is plated, the material can be selected independently without considering the compatibility between the magnet and the casing. For this reason, it is easy to widen the range of material options and to provide higher functionality. Furthermore, long-term stability can be imparted by using a material that does not exhibit biodegradability. Thereby, long-term indwelling inside the living body becomes possible, and application development to various medical treatments becomes possible.

  In the first embodiment, the shield means 20 is applied to impart directivity to the magnetic force, so that it has an excellent feature that a stronger magnetic force can be generated in a pinpoint manner.

[Embodiment 2]
Next, an application example of the magnetic irradiation apparatus of the first embodiment will be described. In the following description, the same elements as those in the above embodiment are denoted by the same reference numerals, and the description thereof is omitted as appropriate.

  The basic structure of the magnetic irradiation apparatus according to the second embodiment is the same as that of the first embodiment. The magnetic irradiation apparatus according to the second embodiment is applied to a drug delivery system.

  In FIG. 4, the schematic explanatory drawing of the drug delivery system which concerns on this Embodiment 2 is shown. The magnetic irradiation apparatus 1 is installed in a stomach 51 that is an affected part of the subject 50. As an installation method, for example, the stomach 51 and the engaging portion 32 of the fixing portion 31 (see FIG. 3A) are fixedly set with a surgical thread or a surgical stapler. Next, a magnetic drug 61 is injected into the blood by injection 60.

  The magnetic drug 61 injected into the blood is accumulated in the affected area by the magnetic force of the magnetic irradiation device 1. The drug 61 is composed of a target substance delivered to the affected area and a substance capable of magnetic induction. Examples of the substance capable of magnetic induction include magnetic nanoparticles. As the magnetic nanoparticles, for example, the technology disclosed in Japanese Patent No. 4183447, Japanese Patent Application Nos. 2008-243279 and 2008-243280 previously filed by Namiki et al. Of the present inventor can be suitably applied.

  The substance intended for magnetically induced delivery of magnetic nanoparticles is not particularly limited, and for example, nucleic acids (eg, DNA, RNA, or analogs or derivatives thereof (eg, peptide nucleic acids, phosphorothioate DNA, etc.) , Peptides, proteins, drugs (for example, anticancer agents, photosensitizers, contrast agents, etc.), sugars, complexes thereof, etc. The form of the nucleic acid is not particularly limited and may be a single strand or Double-stranded, linear or cyclic etc. are mentioned.

  When the substance to be delivered is a nucleic acid, a magnetic nanoparticle-nucleic acid complex is formed through an electrostatic interaction between a negatively charged nucleic acid and a cationic lipid constituting the magnetic nanoparticle. Delivery to the target by magnetic induction of the body is possible. However, if the target substance can be delivered, the method for binding the target substance to the magnetic nanoparticles can be used without any particular limitation.

  According to the drug delivery system according to the second embodiment, it is possible to directly and efficiently deliver and accumulate a drug to an affected area that is a lesion. For this reason, a dramatic improvement in the effect of treatment can be expected. In particular, since the magnetic irradiation apparatus 1 according to the second embodiment can provide directivity, it is possible to more efficiently and pinpointly treat the affected area. Moreover, since the magnetic irradiation apparatus 1 can be left in the living body for a long period of time, the magnetic irradiation apparatus 1 can be installed in the affected area over a period required for treatment. For this reason, a patient's burden can be reduced.

  In the second embodiment, an example in which the affected part is the stomach 51 has been described. However, the present invention is not limited to this, and can be applied to a wide range of places as described in the first embodiment. When the affected part is skin, the medicine may be applied to the contact surface of the magnetic irradiation device 1 with the skin and fixed with a bandage or the like.

  Moreover, the design of the shape of the casing 3 of the magnetic irradiation apparatus 1 can be changed at any time according to the size and shape of the affected part. When the size of the affected part is larger than that of the magnetic irradiation device 1, the size of the magnetic irradiation device 1 itself is increased, and for example, as shown in FIG. And may be adjusted to suit the area of the affected area. Further, the three casings in FIG. 5 may be integrated into one casing. In other words, a casing in which three separated recess-shaped accommodating portions are formed so that three magnets 10 can be accommodated in one casing may be used.

[Embodiment 3]
The basic structure of the magnetic irradiation apparatus according to the third embodiment is the same as that of the first embodiment. The magnetic irradiation apparatus according to the third embodiment is attached to a jig fixing device used for a surgical operation.

  A jig fixing device according to the third embodiment will be described with reference to schematic explanatory views of FIGS. The jig fixing device 5 includes plate-shaped first jig fixing means 70 and second jig fixing means 75 as shown in FIGS.

  As shown in FIG. 6, the first jig fixing means 70 is fixed to the four opening holes 71 into which the accommodating portion 30 of the magnetic irradiation apparatus 1A is fitted, the through holes 32 of the magnetic irradiation apparatus 1A, and the like. A through hole 72, an opening 73 for mounting the first jig, a through hole 74 for mounting an accessory of the first jig, and the like are provided. 6 and 7A, in the first jig fixing means 70, the accommodating portions 30 of the four magnetic irradiation devices 1A are inserted into the opening holes 71, and a titanium bolt 91 and titanium are provided. The through hole 32 of the magnetic irradiation apparatus 1 </ b> A and the through hole 72 of the first jig fixing means 70 are fixed by a nut 92.

  The opening 73 for mounting the first jig is installed at a substantially central position of the disk-shaped first jig fixing means 70 so as to penetrate the opening. An organ fixing balloon tube 81 (hereinafter also referred to as “balloon tube”), which is the first jig, is inserted into the opening 73 and fixed so that the tube does not move. The balloon tube 81 is attached with a balloon 82, a thin tube 83 with a backflow prevention valve that is directly connected to the balloon 82, and a backflow prevention valve 84.

  FIG. 7A shows the magnetic irradiation apparatus 1A and the organ fixing balloon tube 81 fixed to the first jig fixing means 70. FIG. When fixing this to a luminal organ such as the stomach, the balloon 82 is inflated with water after inserting the balloon tube 81 into the incision hole of the luminal organ (see FIG. 7B). Measures for preventing leakage of the luminal organ contents and for preventing the balloon tube 81 from coming off are taken.

  As shown in FIGS. 8A and 8B, the second jig fixing means 75 has four opening holes 71 into which the accommodating portion 30 of the magnetic irradiation apparatus 1B is fitted, and the through hole 32 of the magnetic irradiation apparatus 1B. A through hole 72 for fixing the second jig, an opening 76 for mounting the second jig, and the like are provided. Then, as shown in FIGS. 8A and 8B, the second jig fixing means 75 has four accommodating portions 30 of the magnetic irradiation device 1B inserted into the opening holes 71, and titanium bolts. The through hole 32 of the magnetic irradiation apparatus 1B and the through hole 72 of the second jig fixing means 75 are fixedly provided by 91 and a titanium nut 92.

  The opening 76 for mounting the second jig is installed at a substantially central position of the disk-shaped second jig fixing means 75 so as to penetrate the opening. A tube 80 as a second jig is inserted into the opening 76 and fixed so that the tube does not move.

  The first magnetic irradiation device 1A installed on the first jig fixing means 70 and the second magnetic irradiation device 1B installed on the second jig fixing means 75 have magnetic poles so that they are attracted to each other. It is composed of different things. Thus, the first magnetic fixing means 70 and the second magnetic fixing means 75 are joined by magnetic force.

  Next, a method for fixing the jig fixing device 5 to an organ will be described. First, an incision hole (not shown) penetrating from the outside of the stomach wall to the inside of the stomach wall is provided by surgery. Then, the balloon tube 81 and its accessories are inserted into the incision hole. Next, the first jig fixing means 70 is sewn with a surgical thread outside the stomach wall. Subsequently, in order to prevent the balloon tube 81 from coming off and to prevent leakage between the incision hole and the balloon tube, the balloon 82 is inflated by adding water to the balloon 82.

  Next, the first magnetic irradiation device 1 </ b> A installed in the first jig fixing means 70 and the first magnetic irradiation device 1 </ b> B installed in the second jig fixing means 75 use the magnetic force of the first magnetic irradiation apparatus 1 </ b> B. The fixing means 70 and the second magnetic fixing means 75 are joined. As the first magnetic fixing means 70 and the second magnetic fixing means 75 are joined, the tube 80 of the second jig fixing means 75 is connected to the backflow prevention valve inside the balloon tube 81 of the first jig fixing means 70. Press 84 down. As a result, the tube 80 and the balloon tube 81 are opened, and the internal organs can be drained.

  When the tube 80 is pulled strongly due to an accident or the like, the tube 80 itself is not fixed to the organ, so the first jig fixing means 70 and the second jig fixing means 75 can be connected without damaging the organ. It can be pulled apart against the magnetic force. Also, by separating these, the backflow prevention valve 84 inside the balloon tube 81 functions, and the leakage of liquid inside the organ can be prevented.

  According to the jig fixing means and the jig fixing method according to the third embodiment, the first jig fixing means and the second jig fixing means are joined by a magnetic force so that the attachment / detachment can be easily performed. Can do. In addition, a medical accident can be prevented by adopting a structure in which a predetermined function of the jig is exhibited by joining. Furthermore, as described above, since the method in which the tube is not directly fixed to the organ is employed, damage to the organ can be prevented when the tube is strongly pulled due to an accident or the like.

  In the third embodiment, an example in which the first and second jig fixing means 70 and 75 are integrated by fitting the magnetic irradiation devices 1A and 1B is described. The casing 3 itself of the apparatus 1 may have the shape of the first jig fixing means 70 and the second jig fixing means 75. In other words, in the casing, there may be provided a recess-shaped accommodating portion separated into four that can accommodate the four magnets 10, an opening 73 for mounting the jig, and the like.

  Moreover, the example of the jig | tool which concerns on this Embodiment 3 is an example, and it can apply also to fixation of the position of a surgical instrument, fixation of the drain used at the time of surgery, etc. Furthermore, it is applicable to fixation of dental materials (such as dentures). Further, conventionally, it has not been considered to use a neodymium magnet with low corrosion resistance having the strongest magnetic field among commercially available magnets in the stomach of a cow, but in the magnetic irradiation device 1 according to the present invention, It can also be used as a magnet in the cow's stomach.

<Example>
Hereinafter, the present invention will be described in more detail with reference to examples. Needless to say, the scope of the present invention is not limited to such examples.

Example 1
A magnetic irradiation apparatus 1a as shown in FIG. Specifically, an unmagnetized Ne—Fe—B magnet was used as the magnet 10a. The size of the magnet 10a was a disk shape having an outer diameter of 5 mm and a thickness of 2 mm. A magnetic stainless steel (SUS430) yoke was used as the shield means 20a. The size of the shield means 20a was a cylindrical body having a concave shape as shown in FIG. 10A having an outer diameter of 6.8 mm, an inner diameter of 5.2 mm, an outer height of 3 mm, and an inner height of 2 mm. And the magnetism generating means 2 was produced by mounting the non-magnetized magnet 10 a on the shield means 20.

  Next, a casing 3 having the dimensions shown in FIGS. 10B and 10C was produced using a pure Ti round bar. And after accommodating the magnetic generation means 2 in the inside of the casing 3, ie, the inside of the accommodating part 30a, the cover part 40a was covered.

  Subsequently, TIG welding was performed under an argon gas stream. The magnetism generating means 2a was completely sealed inside the pure Ti casing 3a produced by welding the lid portion 40a and the accommodating portion 30a using pure Ti as a filler material. Then, the magnet 10a was magnetized by irradiating a strong magnetic field from the outside of the casing 3a using a magnetizing power source and a magnetizing coil. Through the above-described steps and the like, the magnetic irradiation device 1a having extremely high safety and durability directivity was produced.

(Example 2)
Using a Gauss meter (GM-5005, manufactured by Electronic Magnetic Industry Co., Ltd.) equipped with a Hall probe (A-550, manufactured by Electronic Magnetic Industry Co., Ltd.), magnetic measurements of the three magnetic irradiation devices 1a were performed. As a result, the magnetism from the surface where the shield means 20a of the magnetic irradiation apparatus 1a is not mounted was 205.8 millitesla on average. On the other hand, the average magnetism from the opposite surface was 3.3 millitesla, and the average magnetism from the side surface of the magnet 10a was 3.1 millitesla. From the above results, it was confirmed that the magnetic irradiation apparatus 1a has a strong magnetic field directivity.

(Example 3)
The magnetic irradiation apparatus 1a produced in Example 1 was put in pure water, 0.9 weight percent physiological saline, or 20 weight percent physiological saline, and left in a constant temperature room at 37 degrees Celsius.

  After 14 days, the magnetic irradiation apparatus 1a was taken out from the temperature-controlled room and checked for corrosion. As a result, it was confirmed visually that there was no discoloration of pure water and physiological saline. It was also confirmed that there was no corrosion of the magnetic irradiation device 1a. Furthermore, it was confirmed that there was no weight change before and after being left.

Example 4
The skin of the rat (experimental animal) was incised after anesthesia treatment, the magnetic irradiation device 1a was inserted subcutaneously, and the skin was sutured. Follow-up was performed on the health of the rats for 14 days. Compared with the non-inserted rat (negative control group) of the magnetic irradiation apparatus 1a, no significant difference was observed in all searched items such as body weight, food intake, water consumption, and skin.

(Example 5)
A magnetism generating means was produced in the same manner as in the first embodiment except that a magnet that had been previously magnetized was used as the magnet housed in the casing 3. The same casing as in Example 1 was used. And after accommodating a magnetic generation means in a casing, the cover part was covered.

  Next, a heat radiating plate was brought into close contact with the titanium case portion, and TIG welding was performed under cooling with a sufficient argon gas flow. In the same manner as in Example 1, the magnetism generating means was completely sealed inside the pure Ti casing by welding the Ti lid and the Ti container. Through the above steps, a directional magnetic irradiation device with extremely high safety and durability was produced.

(Example 6)
Similarly to Example 2, the magnetic measurement of the magnetic irradiation apparatus manufactured in Example 5 was performed. As a result, the magnetism from the surface where the shield means of the magnetic irradiation device is not mounted was 203.5 millitesla on average. On the other hand, the average magnetism from the opposite surface was 3.1 millitesla, and the average magnetism from the side of the magnet was 3.3 millitesla. From the above results, it was confirmed that the magnetic irradiation device had a strong magnetic field directivity.

  Since the highly safe magnetic irradiation apparatus of the present invention can be placed in a living body, it can be suitably applied in a treatment system using magnetism. The magnetic field emitted from the magnetic irradiation device enables the magnetic nanoparticles to be efficiently and safely accumulated in the affected area, and thus can be used as a delivery system for various drugs such as genes, anticancer drugs, and photosensitive substances. Similarly, because it can safely irradiate a strong magnetic field, surgery, surgical procedures, dental procedures, dental materials, medical procedures, disease diagnosis, pharmaceutical manufacturing, veterinary medicine, animal husbandry, agriculture, fisheries, water treatment, It can be used in a wide range of fields such as food processing industry and industry.

FIG. 3 is a perspective view illustrating an appearance of the magnetic irradiation apparatus according to the first embodiment. 1 is an exploded perspective view of a magnetic irradiation apparatus according to Embodiment 1. FIG. (A) The perspective view of the magnetic irradiation apparatus of the state which removed the cover part. (B) Top view of the same. (C) IIIB-IIIB cutting part sectional drawing of FIG.3 (b). Explanatory drawing of the drug delivery system which concerns on Embodiment 2. FIG. FIG. 10 is a schematic top view showing a modification of the magnetic irradiation device used in the drug delivery system according to the second embodiment. The exploded view of the 1st jig fixing means of the jig fixing apparatus which concerns on Embodiment 3. FIG. (A) (b) Explanatory drawing of the 1st jig fixing means of the jig fixing apparatus which concerns on Embodiment 3. FIG. The exploded view of the 2nd jig fixing means of the jig fixing apparatus which concerns on Embodiment 3. FIG. (A) (b) Explanatory drawing which shows the example of mounting | wearing to the organ of the jig | tool fixing device concerning Embodiment 3. FIG. (A) Sectional drawing of the cutting part of the magnetic irradiation apparatus which concerns on Example 1. FIG. (B) (c) Explanatory drawing which shows the dimension of the casing which concerns on Example 1. FIG. Explanatory drawing of the magnetic irradiation apparatus of patent document 1. FIG. (A) The top view of the magnetic irradiation apparatus of patent document 2. FIG. (B) The perspective view.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Magnetic irradiation apparatus 2 Magnetic field line generation means 3 Casing 5 Jig fixing apparatus 10 Magnet 20 Shielding means 30 Storage part 31 Fixing part 32 Through hole 40 Lid part 70 First jig fixing means 71 Opening hole 72 Through hole 73 Opening part 74 Through hole 75 Second jig fixing means

Claims (14)

A magnet,
Including a gap, and a casing in which the magnet is accommodated and sealed in the gap,
The said casing is a magnetic irradiation apparatus comprised with the material which is biocompatible and does not show biodegradability.   The magnetic irradiation apparatus according to claim 1, wherein shielding means is applied to a part of the magnet so that the magnetic force generated from the magnet has directivity.   3. The magnetic irradiation apparatus according to claim 1, wherein the casing is made of any one of a titanium-based material, ceramic, oxynium, and ultra-high molecular polyethylene, or a combination thereof.   The magnetic irradiation apparatus according to claim 1, wherein at least a part of the surface of the casing is an anodized titanium-based material.   The magnetic irradiation apparatus according to claim 1, wherein an oxide film of a titanium-based material is formed on at least a part of the surface of the casing.   The magnetic irradiation apparatus according to any one of claims 1 to 5, wherein the casing is provided with a fixed portion with a subject or a test object.   The in-vivo magnetic irradiation apparatus which installs the magnetic irradiation apparatus of any one of Claims 1-6 inside a subject.   A drug delivery system in which the magnetic irradiation device according to any one of claims 1 to 6 is installed in an affected area, and a magnetic drug injected into a subject is accumulated in the affected area. A first jig fixing means fixed to the subject and provided with a first jig;
A second jig fixing means on which a second jig is installed,
The first jig fixing means and the second jig fixing means each include the magnetic irradiation device according to any one of claims 1 to 6,
A jig fixing device in which the first jig fixing means and the second jig fixing means are configured to be detachable from each other by the magnetic force of the magnetic irradiation device.   The first jig and the second jig jointly perform a predetermined function by joining the first jig fixing means and the second jig fixing means. The jig fixing device according to claim 9.   The jig according to claim 9 or 10, wherein the casing accommodates and seals the magnet and functions as the first jig fixing means and / or the second jig fixing means. Tool fixing device. A first jig is installed, and a first jig fixing means including a first magnetic irradiation device is fixed to the subject;
A second jig fixing means provided with a second jig and provided with a second magnetic irradiation apparatus is used as the first jig fixing means, and the first magnetic irradiation apparatus and the second magnetic irradiation apparatus are used. By the magnetic force of
A jig fixing method in which the first jig and the second jig jointly perform a predetermined function by the joining,
The jig fixing method according to claim 1, wherein the first magnetic irradiation device and the second magnetic irradiation device are the magnetic irradiation devices according to claim 1. Constructed from a material that is biocompatible and does not exhibit biodegradability, and accommodates a non-magnetized magnet in a casing having a gap inside, and seals it.
Then, the manufacturing method of the magnetic irradiation apparatus which magnetizes the said magnet. It is composed of a material that is biocompatible and does not exhibit biodegradability, and contains a magnet magnetized in a casing having a gap inside.
Then, the manufacturing method of the magnetic irradiation apparatus which performs the sealing process of the said casing, performing sufficient cooling.

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