JP2010088342A5 - - Google Patents

Claims (5)

A method of using a single nucleotide polymorphism (SNP) marker for the development of hypertension comprising:
The SNP markers related to the onset of hypertension are the A / G polymorphism SNP (rs number: rs3767489) in the RGS2 gene, the C / A polymorphism SNP (rs number: rs4961) in the ADD1 gene, and the A / G polymorphism SNP in the CACNA2D2 gene ( rs number: rs2236957) and at least two SNPs selected from the group consisting of C / T polymorphic SNPs in the CAT gene (rs number: rs769214),
A preparation step of preparing a test sample, seen containing a typing step of typing said at least two SNPs for the test sample, and a determination step of determining the risk of developing hypertension based on the result of the typing process,
In the determination step, the SNP risk polymorphism of the RGS2 gene is AA type, the SNP risk polymorphism of the ADD1 gene is AA type, the SNP risk polymorphism of the CACNA2D2 gene is AA type, and the CAT A method of using an SNP marker for the development of hypertension , comprising determining that the risk polymorphism of a gene SNP is a TT type and a TC type, and that the risk of developing hypertension increases as the number of the risk polymorphism increases . It is a SNP marker used for the usage method of the SNP marker regarding the onset of hypertension of Claim 1, Comprising: A / G polymorphism SNP (rs number: rs3766789) in RGS2 gene, C / A polymorphism SNP (rs number) in ADD1 gene : Rs4961), A / G polymorphic SNP in the CACNA2D2 gene (rs number: rs2236957), and C / T polymorphic SNP in the CAT gene (rs number: rs769214). marker.   A kit for examining the risk of developing hypertension, comprising an A / G polymorphism SNP in RGS2 gene (rs number: rs3767489), a C / A polymorphism SNP in ADD1 gene (rs number: rs4961), and an A / G in CACNA2D2 gene To type SNPs of SNP markers related to hypertension comprising at least two selected from the group consisting of a polymorphic SNP (rs number: rs2236957) and a C / T polymorphic SNP (rs number: rs769214) in the CAT gene A hypertension risk test kit comprising at least one of a polynucleotide, a primer, a probe, and a DNA microarray. In addition, the instructions include a risk polymorphism of the RGS2 gene SNP (rs number: rs3767489) type AA, and a risk polymorphism of the ADD1 gene SNP (rs number: rs4961) type AA. The risk polymorphism of the SAC (rs number: rs2236957) of the CACNA2D2 gene is AA type, and the risk polymorphism of the SNP (rs number: rs769214) of the CAT gene is TT type and TC type. The hypertension risk test kit according to claim 3 , wherein the risk of developing hypertension increases as the number increases. A method of using a single nucleotide polymorphism (SNP) marker for the development of hypertension comprising:
The SNP marker related to the development of hypertension is a SNP showing linkage disequilibrium with the A / G polymorphism SNP (rs number: rs3767489) in the RGS2 gene, and a linkage disequilibrium with C / A polymorphism SNP (rs number: rs4961) in the ADD1 gene. SNP showing A, G polymorphism SNP (rs number: rs2236957) in CACNA2D2 gene and linkage disequilibrium with SNP showing C / T polymorphism SNP (rs number: rs769214) in CAT gene Consisting of at least two SNPs selected from the group consisting of SNPs;
A preparation step of preparing a test sample, seen containing a typing step of typing said at least two SNPs for the test sample, and a determination step of determining the risk of developing hypertension based on the result of the typing process,
In the determination step, the SNP risk polymorphism of the RGS2 gene is AA type, the SNP risk polymorphism of the ADD1 gene is AA type, the SNP risk polymorphism of the CACNA2D2 gene is AA type, and the CAT Use of a SNP marker for the development of hypertension , comprising determining that the risk polymorphism of a gene SNP is TT type and TC type, and that the risk of developing hypertension increases as the number of polymorphisms linked to the risk polymorphism increases Method.