JP2010058077A - Flask - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a flask capable of preventing a specimen from flowing out in case a gas contained in the specimen foams as a result of bumping in the process of vaporizing a solvent from the specimen, or in case microbubbles resulting from the specimen upon adding an emulsifier are accumulated therein. <P>SOLUTION: The flask 1 pertaining to a first embodiment is to be used in a rotary evaporator 30 by attaching it to a rotary holder 33 thereof. The flask 1 is constituted of a mouth 2 that communicates with the inner part of the flask 1 and the outside and is to be attached to the rotary holder 33, a storage section 3 continuing from the mouth 2 and having a bottom member of a diameter greater than that of the mouth 2, and a plurality of baffle plates 5 supported by the inner wall 3c of the storage section 3 and disposed in the direction of baffling the flow of bubbles resulting from the specimen upon vaporizing a solvent therefrom. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a flask used by being attached to a rotary holder of a rotary evaporator.

As a flask used by being attached to a rotary holder of a rotary evaporator, a flask (round bottom flask) as shown in Patent Document 1 is generally used. This flask is connected to the coupling of the holder of the rotary joint, and rotates in an inclined state in accordance with the rotation of the coupling.
When a solvent is vaporized from a sample with a rotary evaporator to which such a flask is attached, the following process is performed. First, a sample is introduced into the flask, and the inside of the flask is decompressed with a decompression device and heated with a heater. In this state, the flask is rotated for a predetermined time to evaporate the solvent from the sample. At this time, the vaporized solvent is sequentially liquefied and recovered by a cooling recovery device. In this way, a process for concentrating a desired component in the sample is performed.

  By the way, when using a rotary evaporator to evaporate a solvent from a sample under vacuum and heating, a so-called bumping in which gas contained in the sample suddenly foams may occur. In such a case, the sample flows back in the flask shown in Patent Document 1, and a part of the sample may flow out of the flask from the gas suction port of the decompression device or the mouth of the flask.

  In view of this, conventionally, attempts have been made to prevent bumping by devising treatment methods such as gradual decompression gradient in the flask or lowering the heating temperature of the flask. There was a problem that it took time and effort.

  In particular, when dispensing a radiopharmaceutical having a short half-life of about 10 to 110 minutes, it is necessary to perform the work remotely or automatically in a hot cell in order to prevent the radiation exposure of the worker, It is essential to process each process quickly.

  In addition, when dispensing a highly liposoluble sample with physiological saline or the like, it is necessary to add an emulsifier such as polysorbate-80 or polyethylene glycol to prevent the sample from adhering to the inner wall of the flask. However, if an emulsifier is added under vacuum or heating, the viscosity of the emulsifier causes the sample to become a large number of fine bubbles that are carried in the flow direction. In some cases, most of the sample was lost.

  In order to solve such a problem, the applicant of the present application is used in a dispensing device for manufacturing a radiopharmaceutical, and the inside of the partition is divided into two upper and lower chambers, and the partition wall is divided and supported by the central portion of the partition wall. And developed a flask having a cylindrical tube with a number of through holes. According to this flask, since the partition is provided in the flask, it is possible to prevent the solvent or the like from flowing out of the flask due to bumping. Moreover, gas and vapor | steam are discharged | emitted from the inside of a cylindrical pipe | tube by a cylindrical pipe | tube and many through-holes, In that case, the foam | bubble etc. in a cylindrical pipe | tube can be erase | eliminated and it can be made to flow down to a bottom part (refer patent document 2). More specifically, in the flask disclosed in Patent Document 2, a plurality of tube materials are inserted into a cylindrical tube, and a sample is introduced into the flask or a drug or the like is derived through the plurality of tube materials. be able to. In addition, a chemical | medical agent means what prepared the predetermined density | concentration by dissolving physiological saline etc. in the desired component which vaporized the solvent from the sample and dried.

  Next, the structure of the conventional flask attached to the conventional rotary evaporator shown in FIG. 9 will be described. The applicant of the present application has developed a rotary evaporator 100 in which dispensing and cleaning processes are automated as shown in FIG. 9, and a partition wall 115 that divides and partitions a flask 110 attached to the rotary evaporator 100 into two upper and lower chambers. In addition, a cylindrical tube 119 that penetrates the central portion of the partition wall 115 and is supported by the partition wall 115 is provided (see Patent Document 3 for details).

JP 2000-279703 A Japanese Patent No. 3513573 Japanese Patent Application No. 2007-258839

  However, since the inside of the flask is partitioned and divided into two upper and lower chambers by the partition wall, there is a drawback in that it is difficult to perform a cleaning operation and the like because it communicates only with the cylindrical tube arranged at the center. Furthermore, since vapor and bubbles come out only from the cylindrical tube and a large number of through holes, the flow velocity of that part becomes extremely fast, and the liquid generated from the bubbles that have entered the cylindrical tube or bubbles that have been extinguished in the cylindrical tube flows. There was a risk of being carried in the direction and escaping out of the flask through the mouth. The flask 110 disclosed in Patent Document 3 shown in FIG. 9 has the same problem.

  Moreover, since the flask disclosed in Patent Document 2 has a structure for use in a dispensing device for manufacturing a radiopharmaceutical that completely automates the dispensing process of a short half-life radiopharmaceutical, when used in a general rotary evaporator While effective in preventing loss of the sample due to bumping, there is a problem that it is difficult to introduce and lead out the sample from the mouth of the flask, and it is difficult to perform the washing operation, resulting in poor operability.

  That is, when using the flask disclosed in Patent Document 2 attached to a general rotary evaporator, it is necessary to manually introduce a sample or the like, but manually according to the opening of the cylindrical tube of the flask. It was difficult to introduce the sample. In addition, if it spills around the cylindrical tube and spreads on the partition wall, it is difficult to recover all and re-introduce it. Furthermore, when the medicine or the like is led out from the flask disclosed in Patent Document 2, it is difficult to manually collect the liquid in the flask because of the partition wall and the cylindrical tube. Thus, when the liquid residue in the flask increases, there is a problem that the cleaning efficiency to be performed thereafter decreases and the operability is inferior. In addition, liquid generated from a large amount of bubbles for the above-mentioned reasons or from the foam extinguished in the cylindrical tube may be transported to the mouth portion and flow out of the flask due to a fast outflow speed.

  The present invention has been made in view of the above-described problems. When bumping occurs and the gas contained in the sample is foamed, or when the sample is accumulated as fine bubbles due to the addition of an emulsifier, bubbles are generated. It is an object of the present invention to provide a flask that can prevent the converted sample from flowing out of the flask, has excellent operability, and can be applied to various types of rotary evaporators.

  The flask of the present invention that has solved the above problems is a flask that is used by being attached to a rotary holder of a rotary evaporator. The flask communicates the inside and the outside of the flask, and the mouth that is attached to the rotary holder; When having a bottomed housing part that is continuous from the mouth and has a diameter larger than the mouth part, and a baffle plate supported by the inner wall of the housing part, the baffle plate vaporizes the solvent from the sample. And a gap is formed between the baffle plate and the inner wall of the housing portion. Note that “bubbles” refer to bubbles when a sample is foamed due to bumping, or bubbles when the sample accumulates as fine bubbles due to the addition of an emulsifier.

  According to the flask of the present invention, since the baffle plate is provided in a direction that hinders the flow of bubbles generated from the sample in the container, the flask is attached to the rotary holder of the rotary evaporator, the sample is introduced from the mouth to the container, -When the solvent is vaporized from the sample under heating, bubbles generated from the sample and carried in the flow direction can be removed by a baffle plate to form a liquid, and then flow down to the bottom again. For this reason, it can prevent that a sample flows out of a flask through a mouth part, and can prevent loss of a sample.

  In addition, since a gap is formed between the baffle plate and the inner wall of the container, when introducing the sample, the mouth of the flask faces upward and the liquid introduced from the mouth is moved along the inner wall of the mouth and the container. Accordingly, the liquid can be made to flow down to the bottom, and thereby, the liquid can be easily introduced into the storage portion. Also, when the drug is derived, contrary to the case where the sample is introduced, the mouth of the flask is turned downward, and the liquid in the container is allowed to flow along the inner wall of the container and the mouth. The liquid can be easily led out. For this reason, the residue of the medicine after dispensing can be reduced. Furthermore, such a feature is not only advantageous for cleaning, but also makes it easier for a sample scattered on the inner wall portion of the housing portion due to bumping or a liquid generated from bubbles erased by the baffle plate to flow down to the bottom portion.

  In the flask of the present invention, it is preferable that a plurality of the baffle plates are arranged around the axis of the housing portion with a space therebetween.

  According to this, since the flow of steam and bubbles can be dispersed, the flow rate of steam and bubbles can be maintained gently. For this reason, it is possible to prevent the liquid generated from the foam generated from the sample or the foam erased by the baffle plate from flowing out of the flask from the mouth.

In the flask of the present invention, it is preferable that the baffle plates are arranged in a plurality of stages at intervals in the height direction of the housing portion.
According to this, by arranging a plurality of baffle plates at a predetermined interval in the height direction of the housing portion, the liquid splashed by bubbles or bumping can be more surely erased before reaching the mouth portion. Loss can be prevented more reliably.

  In the flask of the present invention, a plurality of the baffle plates are arranged with an interval in the axial center of the housing portion, and the plurality of baffle plates are arranged with a space in the height direction of the housing portion. It is preferable that the plurality of baffle plates on the upper stage and the plurality of baffle plates on the lower stage are arranged so as to be shifted from each other so as not to overlap each other in plan view.

  According to this, since the flow of vapor and bubbles can be further dispersed, it is possible to more reliably prevent the liquid scattered by bubbles and bumping from reaching the mouth and flowing out of the flask.

  The flask of the present invention has a recess formed by recessing the bottom portion outward at a position facing the mouth, and is supported by the inner wall of the storage section at a position facing the recess and the mouth. It is preferable that a cylindrical tube extending in the height direction of the housing portion is disposed and the baffle plate is attached to the outer peripheral surface of the cylindrical tube.

According to this, it can be applied to a rotary evaporator in which drug dispensing processing and cleaning processing are completely automated.
Here, in the rotary evaporator in which the drug dispensing process and the cleaning process are completely automated, as disclosed in Patent Document 2, a tube material is provided in the flask for introducing a sample into the container and for extracting the drug. Communicated. For example, if the flask can be varied between a tilted state and a vertical state, the sample is introduced into the container with the flask tilted, and after processing, the flask is placed in a vertical state and the drug is placed at the bottom. And can be led out with a tube material.

  According to the flask of the present invention, bubbles generated from the sample can be eliminated by the baffle plate attached to the outer peripheral surface of the cylindrical tube, and the sample scattered by bumping can flow down to the bottom. . Thereby, the foamed sample can be prevented from flowing out of the flask from the mouth portion of the flask, and sample loss can be prevented. In addition to this, since a recess is provided in the bottom, when applied to a rotary evaporator that fully automates the dispensing and cleaning of the drug, the drug flowing down to the bottom can be stored in the recess, and the tube material is By inserting the tip, it is possible to easily collect the drug accumulated in the recess from the tip of the tube material.

  For this reason, it is possible to improve the recovery efficiency of the medicine and improve the washing efficiency and washing accuracy when the flask is subsequently washed because the drug residue in the container can be reduced. it can. In addition, it is possible to easily collect the cleaning liquid after cleaning the inside of the housing part and the tube material.

  More preferably, the cylindrical tube has an opening end on the mouth side larger in diameter than an opening end on the recess side.

  According to this, in addition to the above-described operation, the opening on the mouth side of the cylindrical tube is formed to have a larger diameter than the opening on the concave side, so that the tube material can be easily communicated with the inside of the cylindrical tube. At the same time, since the opening on the concave portion side of the cylindrical tube has a smaller diameter than the opening on the concave portion side, the tip of the tube material communicating with the inside of the cylindrical tube can be easily guided to the concave portion.

  According to the flask of the present invention, a baffle plate for eliminating bubbles generated from the sample is provided in the container, so that gas contained in the sample is foamed by bumping, or fine bubbles are accumulated in the container by adding an emulsifier. Even when the sample is taken, the sample can be prevented from flowing out of the flask through the gas suction port or the mouth portion. Further, the liquid scattered by bumping can be applied to the baffle plate and flowed down to the bottom. Furthermore, since a gap is formed between the baffle plate and the inner wall portion of the housing portion, even when the liquid scatters to the vicinity of the mouth due to bumping, the liquid can flow down to the bottom portion along the inner wall portion. For this reason, loss of the sample in the step of vaporizing the solvent from the sample can be prevented. Moreover, it is excellent in operativity compared with the flask provided with the conventional baffle plate, and can be applied to various types of rotary evaporators.

  Next, the flask according to the first embodiment of the present invention will be described with reference to the drawings as appropriate. In the drawings to be referred to, FIG. 1 is a partially sectional perspective view showing a configuration of a flask according to a first embodiment of the present invention, FIG. 2A is a sectional view taken along line AA in FIG. 1 is a cross-sectional view taken along line BB in FIG. 1, and FIG. 3C is a cross-sectional view taken along line CC in FIG. In FIG. 1, in order to make the internal structure of the flask easy to see, a part of the external shape of the flask is shown in cross section.

  As shown in FIG. 1, the flask 1 according to the first embodiment has a mouth 2 that communicates the inside and the outside of the flask 1, and a bottomed base that is continuous from the mouth 2 and has a larger diameter than the mouth 2. And the baffle plate 5 supported by the inner wall portion 3c of the housing portion 3. The bottom part 3b of the accommodating part 3 is formed in a hemispherical shape in the first embodiment. The flask 1 according to the first embodiment is attached to the rotary holder 33 of the rotary evaporator 30 through the mouth portion 2 as described later. Below, the mouth part 2 side of the flask 1 is set as the upper side, and the bottom part 3b side is set as the lower side.

The baffle plate 5 is provided in a direction that obstructs the flow path of bubbles generated from the sample when the solvent is vaporized from the sample. In the first embodiment, the baffle plate 5 is provided in the horizontal direction with the flask 1 being vertical. ing. Further, the baffle plate 5 is supported by the inner wall portion 3 c of the housing portion 3 via the support member 7.
As shown in FIGS. 1 and 2 (a), the baffle plate 5 in the first embodiment is configured by three fan-shaped thin plate members opened at approximately 60 ° arranged at equal intervals in the circumferential direction. Yes.

  As shown in FIG. 2A, the baffle plate 5 is provided at a position that is higher than half of the height dimension from the upper end portion 3a to the bottom portion 3b of the accommodating portion 3 in this embodiment. Thereby, it becomes possible to process more samples efficiently.

  Further, the baffle plate 5 is formed to have a smaller diameter than the inner diameter of the accommodating portion 3. For example, it is preferable to form the baffle plate 5 so that the gap S1 between the outer peripheral surface of the baffle plate 5 and the inner wall portion 3c is 1.5 mm or more and 3.0 mm or less. If the gap S1 is smaller than 1.5 mm, the gap S1 between the outer peripheral surface of the baffle plate 5 and the inner wall 3c is too narrow, and the sample accumulates in the gap S1 due to the surface tension, and further bubbles are generated therefrom. It is because there is a possibility of doing. On the other hand, if the gap S3 is 3.0 mm or more, the gap S1 between the outer peripheral surface of the baffle plate 5 and the inner wall 3c is too wide, and bubbles pass through the gap S1 to reach the mouth portion 2, This is because the part 2 may flow out of the flask 1.

  As shown in FIG. 1 and FIG. 2A, in the first embodiment, the three baffle plates 5 configured in this way are arranged in two stages at intervals in the height direction of the accommodating portion 3. Has been. That is, the baffle plate 5 is positioned so that the upper three baffle plates 5 and the lower three baffle plates 5 do not substantially overlap in plan view, as shown in FIGS. They are staggered. As described above, the positions of the upper baffle plate 5 and the lower baffle plate 5 are shifted in the circumferential direction, whereby the flow of bubbles and steam can be dispersed. Note that the upper baffle plate 5 and the lower baffle plate 5 may have a portion that overlaps slightly.

  By arranging in this way, the bottom portion 3b side is not visible from the mouth portion 2 side of the flask 1, that is, the upper baffle plate 5 and the lower baffle plate 5 are arranged without gaps in the circumferential direction of the housing portion 3. Therefore, when the foam generated from the sample flows from the bottom 3b side toward the mouth 2 side, it is surely put on either the upper baffle plate 5 or the lower baffle plate 5 to be turned into a liquid, It can be made to flow down to the bottom 3b. For this reason, it is possible to prevent the sample from flowing out from the mouth portion 2.

  Further, the upper baffle plate 5 and the lower baffle plate 5 are respectively attached to the outer peripheral surface of the column 6 arranged along the central axis of the flask 11, and are arranged on the outer peripheral surfaces of the two upper baffle plates 5. The other end side of the support member 7 having one end side attached to the inner wall portion 3c of the accommodating portion 3 is attached by, for example, spot welding. In this way, the column 6 and the upper baffle plate 5 and the lower baffle plate 5 attached to the outer peripheral surface of the column 6 are supported by the inner wall portion 3 c of the housing portion 3 through the support member 7. The support member 7 may extend from the outer peripheral surface of the column 6 toward the inner wall portion 3 c of the housing portion 3. Moreover, the number of installation of the supporting member 7 can be changed suitably.

Next, an operation when the flask 1 according to the first embodiment configured as described above is used by being attached to a general rotary evaporator will be described with reference to FIG. FIG. 3 is a view showing a state in which the flask according to the first embodiment of the present invention is attached to a rotary evaporator. Below, the case where the dispensing process of a chemical | medical agent is performed as an example is demonstrated.
Here, the drug means a solution prepared by dissolving physiological saline or the like in a desired component obtained by evaporating a solvent from a sample and drying it to a predetermined concentration. Of course, the flask 1 can be used not only when a medicine is dispensed by a rotary evaporator, but also when different compounds are synthesized into another compound.

  The rotary evaporator 30 shown in FIG. 3 is appropriately made of a known material except that the flask is the flask 1 according to the first embodiment. Here, a configuration other than the flask 1 in the rotary evaporator 30 shown in FIG. 3 will be briefly described. As shown in FIG. 3, the rotary evaporator 30 is connected to a heater 32 for heating the flask 1, a motor (not shown), a rotary holder 33 for attaching the flask 1 and rotating it, and a rotary holder 33. 34 mainly includes a shaft member 35 that is supported by the motor 34, and a cooling and recovery device 36 that cools the vaporized solvent and liquefies and recovers it. The rotary evaporator 30 is connected to a decompression device (not shown) and a control device. A decompression device (not shown) is connected to the mouth portion 2 of the flask 1 so that the interior of the flask 1 is decompressed.

  Such a rotary evaporator 30 is operated to vaporize a solvent from the sample and concentrate a desired component in the sample. For example, in the conventional processing procedure, first, the flask 1 is supported on the installation base 34 by the shaft member 35 in a state where the flask 1 is inclined at 45 °, for example.

  Then, all the samples are introduced from the mouth portion 2 into the housing portion 3. Subsequently, while the pressure inside the flask 1 is reduced to a predetermined degree of vacuum with a pressure reducing device (not shown), the periphery of the bottom 3 b of the housing 3 is heated at, for example, 100 ° C. with the heater 32. At the same time, the rotary holder 33 rotates the flask 1 for a predetermined time to evaporate the solvent from the sample. At this time, the evaporated solvent is sequentially liquefied by the cooling recovery device 36 and recovered.

  According to this procedure, since all of the sample is introduced into the container 3 and then decompressed and heated, the gas contained in the sample can be sucked by the decompression device (not shown) before the sample is warmed. For this reason, since the quantity of the gas in the flask 1 can be decreased and generation | occurrence | production of a bubble can be suppressed, it is preferable.

  In the process of vaporizing the solvent from the sample in such a procedure, bubbles generated by foaming of the gas contained in the sample due to bumping move from the bottom 3b side of the container 3 toward the mouth 2 side which is the outlet side of the flow path. And flow. In the flask 1 according to the first embodiment, the baffle plates 15 are arranged in two stages at intervals in the height direction of the housing portion, and the upper baffle plate 5 and the lower baffle plate 5 are viewed in plan view. Since they are arranged so as not to overlap each other, the bubbles flowing from the bottom 3b toward the mouth 2 can be applied to either the upper baffle plate 5 or the lower baffle plate 5 to be erased. In addition, since bubbles and steam can be dispersed, the flow rate can be maintained gently.

  As a result, the foam becomes liquid and flows down to the bottom portion 3b through the inner wall portion 3c of the accommodating portion 3 by gravity, so that the sample can be prevented from flowing out of the flask 1 from the mouth portion 2. Further, even when fine bubbles are generated and accumulated due to the addition of the emulsifier, the sample can be removed from the mouth portion 2 because it can be applied to either the upper baffle plate 5 or the lower baffle plate 5 in the same manner. Outflow from the flask 1 can be prevented. In addition, since gaps are formed between the upper and lower baffle plates 5 and the inner wall portion 3c of the housing portion 3, even when the sample is scattered in the flask 1 due to bumping, the bottom portion 3b is transmitted along the inner wall portion 3c. Can flow down. For this reason, it is possible to prevent the sample from remaining in the flask 1.

  According to the flask 1 according to the first embodiment described above, the baffle plates 5 are arranged in two stages at an interval in the height direction of the accommodating portion 3, and further, the upper baffle plate 5 and the lower baffle plate Since the baffle plate 5 is arranged without any gap in the circumferential direction in the flask 1 by arranging so that it does not substantially overlap with 5 in plan view, the gas dissolved in the sample is foamed or the sample is fine by adding an emulsifier Even in the case of accumulation as bubbles, the bubbles can be made liquid by erasing them against the baffle plate 5 and flowing down to the bottom 3b by gravity. Further, even when the liquid splashes into the flask 1 due to bumping, the liquid can be applied to the baffle plate 5 and flowed down to the bottom 3b by gravity. For this reason, it is possible to prevent the sample from flowing out of the flask 1 from the mouth portion 2.

  Furthermore, according to the flask 1 according to the first embodiment, since a gap is formed between the baffle plate 5 and the inner wall portion 3c of the accommodating portion 3, when the sample is introduced, the mouth portion 2 of the flask 1 is turned upward. The liquid introduced from the mouth portion 2 can flow down to the bottom portion 3b along the inner wall 3c of the mouth portion 2 and the inner wall portion 3c of the housing portion 3, thereby facilitating the introduction of the liquid into the housing portion 3. Can do. Further, when the drug is derived, contrary to the case of introducing the sample, the mouth part 2 of the flask 1 faces downward, and the liquid in the storage part 3 flows down along the inner wall part 3 c and the inner wall of the mouth part 2. Thus, the liquid can be easily led out from the mouth portion 2. Further, even when the liquid scatters to the vicinity of the mouth portion 2 due to bumping, it can flow down to the bottom portion 3b through the inner wall portion 3c. For this reason, the residue of the chemical | medical agent after the sample in the flask 1 and dispensing can be decreased.

  Furthermore, according to the flask 1 according to the first embodiment, the loss of the sample can be prevented by a normal usage method, so that the heating temperature of the flask 1 is lowered to prevent bumping, or the reduced pressure gradient in the flask 1 It is no longer necessary to loosen. For this reason, the time for vaporizing the solvent from the sample can be shortened, and thereby the dispensing process can be speeded up.

  In the first embodiment, three baffle plates 5 are arranged around the axis of the housing portion 3. However, the present invention is not limited to this, and the number of baffle plates 5 can be set as appropriate.

Next, the flask 11 according to the second embodiment of the present invention will be described. FIG. 4 to be referred to is a partial cross-sectional perspective view of the flask according to the second embodiment of the present invention. In FIG. 4, in order to make the internal structure of the flask easy to see, a part of the external shape of the flask is shown in cross section.
5A is a sectional view taken along the line DD in FIG. 4, FIG. 5B is a sectional view taken along the line EE in FIG. 4, and FIG. 5C is a sectional view taken along the line FF in FIG.
In the flask 11 which concerns on 2nd embodiment, about the component which overlaps with the flask 1 which concerns on 1st embodiment, the same code | symbol is attached | subjected and the overlapping description is abbreviate | omitted.

  As shown in FIG.4 and FIG.5 (a), the flask 11 which concerns on 2nd embodiment is the opening part 2, the accommodating part 3, and the supporting member 7 which are the structures of the flask 1 which concern on 1st embodiment. In addition, the baffle plate 15, the concave portion 8, and the cylindrical tube 9 are mainly included. In the flask 11 according to the second embodiment, an introduction tube 46 (see FIG. 6) for introducing a sample and the like, and a drug obtained by concentrating the introduced sample and the like are derived. The lead-out tube 47 (see FIG. 6) is inserted. Details will be described later.

  In the housing part 3, a concave part 8 is formed at a position facing the mouth part 2 by further denting the bottom part 3 b to the outside of the flask 11. The recess 8 can be inserted with a leading end of a lead-out tube 47 (see FIG. 6) for leading out the medicine and the like. Further, the recess 8 has a formation dimension slightly larger than the formation dimension of the leading end of the lead-out tube 47 (see FIG. 6) so that the lead-out tube 47 (see FIG. 6) can be easily inserted. When the tip of FIG. 6) is arranged, it is preferably formed so as to have a slight gap around the tip of the outlet tube 47 (see FIG. 6).

  The cylindrical tube 9 is a hollow cylindrical member disposed in the vicinity of the mouth portion 2 of the housing portion 3 and coaxially with the mouth portion 2 and the recessed portion 8. The cylindrical tube 9 includes an upper opening end 9a (corresponding to an “opening end on the mouth side” in the claims) located on the mouth 2 side, a body portion 9b continuous with the upper opening end 9a, and a body It has a lower opening end 9c (corresponding to “opening end on the concave portion side” in the claims) that is continuous with the portion 9b and is located on the concave portion 8 side. The cylindrical tube 9 is formed to have a diameter increasing from the body portion 9b toward the upper opening end 9a, while being reduced in diameter toward the lower opening end 9c from the body portion 9b.

  With this configuration, the introduction tube 46 (see FIG. 6) and the lead-out tube 47 guided from the mouth portion 2 into the housing portion 3 can be easily guided from the upper opening end 9a having a large diameter to the inside thereof. At the same time, the leading end of the outlet tube 47 (see FIG. 6) that has passed through the body portion 9b can be easily guided to the concave portion 8 from the lower opening end 9c having a reduced diameter.

  Further, as shown in FIG. 5A, the cylindrical tube 9 is arranged so that the gap S2 between the upper opening end 9a of the cylindrical tube 9 and the inner wall portion 3c of the accommodating portion 3 is 1.5 mm or more and 3.0 mm or less. It is preferable. If the gap S2 is smaller than 1.5 mm, the gap between the upper opening end 9a and the inner wall portion 3c is too narrow, and the sample accumulates in the gap S2 due to surface tension, and further bubbles are generated therefrom. This is because there is a fear. On the other hand, if the gap S2 is larger than 3.0 mm, the gap S2 between the upper opening end 9a and the inner wall portion 3c is too wide, and bubbles pass through the gap S2 to reach the mouth portion 2 as it is. This is because there is a possibility that it will be leaked.

  The flask 11 according to the second embodiment includes three baffle plates 15 attached at equal intervals to the outer peripheral surface near the upper opening end 9 a of the body portion 9 b of the cylindrical tube 9, and the body portion 9 b of the cylindrical tube 9. And three baffle plates 15 attached at equal intervals to the outer peripheral surface near the lower opening end 9c. The baffle plate 15 is provided in a direction that obstructs the flow path of bubbles generated from the sample when the solvent is vaporized from the sample.

  Moreover, as shown in FIG.4 and FIG.5 (b), in the flask 11 which concerns on 2nd embodiment, one end side is attached to the inner wall part 3c of the accommodating part 3 in the outer peripheral surface of the upper three baffle plates 15 The other end sides of the support members 7 are attached by, for example, spot welding. In this way, the cylindrical tube 9 and the upper baffle plate 15 and the lower baffle plate 15 attached to the outer peripheral surface of the cylindrical tube 9 are supported by the inner wall portion 3 c of the housing portion 3 through the support member 7. Note that the support member 7 may extend from the outer peripheral surface of the cylindrical tube 9 toward the inner wall portion 3 c of the housing portion 3. Moreover, the number of installation of the supporting member 7 can be changed suitably.

  Here, as shown in FIGS. 5B and 5C, the upper baffle plate 15 and the lower baffle plate 15 are arranged so as to be shifted from each other so that they do not substantially overlap in a plan view. That is, when the upper baffle plate 15 and the lower baffle plate 15 are combined, there is no gap in the circumferential direction in the flask 11. Further, the upper baffle plate 15 and the lower baffle plate 15 are formed to have a smaller diameter than the inner diameter of the accommodating portion 3. The gap S3 between the upper baffle plate 15 and the lower baffle plate 15 and the inner wall 3c of the housing portion 3 is preferably 1.5 mm or more and 3.0 mm or less. Note that the upper baffle plate 15 and the lower baffle plate 15 may have a portion that overlaps slightly.

  The operation when the flask 11 according to the second embodiment configured as described above is attached to the rotary evaporator 40 and the solvent is vaporized from the sample will be described with reference to FIGS. FIG. 6 is a view showing a state in which the flask according to the second embodiment of the present invention is attached to the rotary evaporator, and FIGS. 7A and 7B are views for explaining the operation of the rotary evaporator shown in FIG. FIG.

  Here, the structure of the rotary evaporator 40 shown in FIG. 6 is demonstrated easily. A rotary evaporator 40 shown in FIG. 5 includes a heater 42, a rotary holder 43, a shaft member 45 that supports the rotary holder 43 on an installation base 44, an introduction tube 46 for introducing a sample or the like into the flask 11, A deriving tube 47 for deriving a drug obtained by concentrating the obtained sample or the like, a support member 48 for changing the rotary holder 43 between an inclined state and a vertical state, and a rotary holder The motor 49 for rotating 43 is mainly comprised. The heater 42 has an accommodation space that is slightly larger than the size of the outer peripheral surface around the bottom 3 b of the flask 11, and the flask 11 is disposed in this space. Further, the heater 42 is tilted together with the flask 11 when the flask 11 is tilted, and becomes vertical together with the flask 11 when the flask 11 is vertical.

  As the introduction tube 46 and the lead-out tube 47, for example, a known tube tube or a fluororesin tube can be used. In addition, the lead-out tube 47 is long enough to insert the tip into the recess 8.

  Such a rotary evaporator 40 is operated to perform a process of evaporating a solvent from the sample and concentrating a desired component in the sample. First, as shown in FIG. 7A, the shaft member 45 is rotated to bring the flask 11 into an inclined state, and the pressure inside the flask is reduced to a predetermined degree of vacuum with a pressure reducing device (not shown). All the samples are introduced into the accommodating portion 3 through the introduction tube 46 while rotating the flask 11 to rotate the flask 11. During this process, most of the gas dissolved in the sample is removed. Next, the flask 11 is heated by the heater 42 to evaporate the solvent, and a process of concentrating the desired components in the sample is performed.

  Since the flask 11 according to the second embodiment is arranged so that the upper three baffle plates 15 and the lower three baffle plates 15 do not substantially overlap in a plan view, Even when bubbles are generated from the sample, the bubble flowing from the bottom 3b side toward the mouth 2 side or the sample scattered by bumping is applied to either the upper baffle plate 15 or the lower baffle plate 15. It can be extinguished and made liquid to flow down to the bottom 3b. For this reason, loss of the sample due to the sample flowing out from the mouth portion 2 can be prevented.

  Next, the heater 42 is stopped and the solvent is completely evaporated by the remaining heat. Further, for example, physiological saline is introduced into the storage portion 3 through the introduction tube 46, and the flask 1 is rotated for a predetermined time to prepare the drug at a predetermined concentration. Subsequently, the rotation of the flask 11 is stopped, and the state in which the flask 11 is inclined by the shaft member 45 is changed to the vertical state as shown in FIG. Since the flask 11 according to the second embodiment has the concave portion 8 in the bottom portion 3 b, the medicine that has spread around the bottom portion 3 b of the storage portion 3 can be collected in the bottom portion 3 b and the concave portion 8. Further, since the tip of the outlet tube 47 is inserted into the recess 8, the medicine can be led out through the outlet tube 47 by feeding nitrogen gas into the flask 11. At this time, when the remaining amount of the medicine decreases, the medicine naturally flows down into the recess 8, so that almost all of the medicine in the container 3 can be derived.

  In addition, since the concave portion 8 and the cylindrical tube 9 are provided, the recovery efficiency of the medicine can be improved, so that the residual amount of the medicine in the storage portion 3 can be reduced. Thereby, the efficiency of the cleaning work performed after that can be improved. Therefore, when a plurality of medicines are continuously dispensed in one flask 11, cross contamination can be made difficult to occur.

  Next, the flask 21 which changed the baffle plate 15 of the flask 11 which concerns on 2nd embodiment of this invention into the baffle plate 25 is demonstrated, referring drawings. FIG. 8 to be referred to is a diagram showing a configuration of a modified example of the flask according to the second embodiment of the present invention, and (a) shows a baffle plate of the flask according to the second embodiment of FIG. The figure changed into the baffle plate which concerns on a modification, (b) is the figure which changed the baffle plate of the flask which concerns on 2nd embodiment of FIG.5 (b) into the baffle plate which concerns on a modification, (c) is a figure It is the figure which changed the baffle plate of the flask which concerns on 2nd embodiment of 5 (c) into the baffle plate which concerns on a modification.

  As shown in FIG. 8A, the baffle plate 25 according to the modification is formed by partially cutting the inner end side of the baffle plate 15, and is spaced from the outer peripheral surface near the upper opening end 9 a of the cylindrical tube 9. Three pieces are arranged at intervals, and three pieces are arranged at intervals on the outer peripheral surface of the cylindrical tube 9 near the lower opening end 9c. The upper and lower baffle plates 25 are respectively attached to the outer peripheral surface of the cylindrical tube 9 by support members 27b passed between the inner end side and the cylindrical tube 9. Further, the other end side of the support member 27 a whose one end side is connected to the inner wall portion 3 c of the housing portion 3 is connected to one of the upper baffle plates 25. Further, the upper baffle plate 25 and the lower baffle plate 25 are formed to have a smaller diameter than the inner diameter of the accommodating portion 3. The clearance S4 between the upper baffle plate 25 and the lower baffle plate 25 and the inner wall 3c of the housing portion 3 is preferably 1.5 mm or more and 3.0 mm or less.

  By comprising in this way, preparation of the flask 21 becomes easy. Further, since a gap is formed between the baffle plate 25 and the cylindrical tube 9, it is difficult for the liquid to remain on the baffle plate 25 as compared with the case where the baffle plate 25 and the cylindrical tube 9 are directly connected. That is, when the baffle plate 25 and the cylindrical tube 9 are directly connected, a liquid may adhere to the connection portion between the baffle plate 25 and the cylindrical tube 9 due to surface tension. Since a gap is formed between the plate 25 and the cylindrical tube 9, this can be made difficult to occur. For this reason, it is possible to prevent bubbles from being regenerated from the liquid remaining on the baffle plate 25.

  As mentioned above, although embodiment of this invention was described, this invention is not limited to above-described embodiment. For example, in each of the above-described embodiments and modifications, a plurality of fan-shaped thin plate members are arranged around the column or cylindrical tube at intervals to form the baffle plate 5, the baffle plate 15, and the baffle plate 25. Not limited.

  For example, the baffle plate may be a single disk slightly smaller than the inner diameter of the flask, a plurality of through holes may be formed on the surface, and the baffle plate may be arranged in two stages at intervals in the height direction of the housing portion. By adopting such a configuration, it is possible to easily introduce a sample or the like through a plurality of through-holes and lead out a drug or the like, and it is possible to gently maintain the flow rate of steam or bubbles. For this reason, it is possible to prevent the liquid generated from the bubbles or the bubbles erased by the baffle plate from flowing out of the flask from the mouth.

It is a partial cross section perspective view which shows the structure of the flask which concerns on 1st embodiment of this invention. (A) is the sectional view on the AA line of FIG. 1, (b) is the sectional view on the BB line of FIG. 1, (c) is the sectional view on the CC line of FIG. It is a figure which shows a mode that the flask which concerns on 1st embodiment of this invention was attached to the rotary evaporator. It is a partial cross section perspective view which shows the structure of the flask which concerns on 2nd embodiment of this invention. (A) is the DD sectional view taken on the line of FIG. 4, (b) is the EE sectional view taken on the line of FIG. 4, (c) is the FF sectional view taken on the line of FIG. It is a figure which shows a mode that the flask which concerns on 2nd embodiment of this invention was attached to the rotary evaporator. (A) And (b) is a figure which shows operation | movement of the rotary evaporator shown in FIG. It is a figure which shows the structure of the modification of the flask which concerns on 2nd embodiment of this invention, (a) is the baffle which concerns on the baffle which concerns on the modification of the baffle of the flask which concerns on 2nd embodiment of Fig.5 (a) FIG. 5B is a diagram in which the baffle plate of the flask according to the second embodiment in FIG. 5B is changed to a baffle plate according to a modification, and FIG. 5C is a diagram of FIG. It is the figure which changed the baffle plate of the flask which concerns on 2 embodiment into the baffle plate which concerns on a modification. It is a partial cross section perspective view which shows the structure of the conventional flask attached to the conventional rotary evaporator.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1, 11, 21 Flask 2 Mouth part 3 Accommodating part 3a Upper end part 3b Bottom part 3c Inner wall part 5, 15, 25 Baffle plate 6 Column 7, 27 Support member 8 Recessed part 9 Cylindrical tube 30, 40 Rotary evaporator 32, 42 Heater 33, 43 Rotary holder 34, 44 Installation base 35, 45 Shaft member 36 Cooling recovery unit 46 Introducing tube 47 Deriving tube 48 Supporting member 49 Motor

Claims (6)

A flask used by being attached to a rotary holder of a rotary evaporator,
Communicating the inside and the outside of the flask, and a mouth part attached to the rotary holder;
A bottomed housing portion that is continuous from the mouth and has a diameter larger than the mouth;
A baffle plate supported by the inner wall portion of the housing portion,
The baffle plate is provided in a direction that prevents the flow of bubbles generated from the sample when the solvent is vaporized from the sample,
A flask characterized in that a gap is formed between the baffle plate and the inner wall of the housing part. 2. The flask according to claim 1, wherein a plurality of the baffle plates are arranged at an interval with respect to an axis of the housing portion. The flask according to claim 1 or 2, wherein the baffle plates are arranged in a plurality of stages at intervals in the height direction of the housing portion. A plurality of the baffle plates are arranged with an interval in the axis of the accommodating portion,
The plurality of baffle plates are arranged in two stages at intervals in the height direction of the housing portion,
The flask according to claim 1, wherein the upper plurality of baffle plates and the lower plurality of baffle plates are arranged so as to be shifted from each other so as not to substantially overlap in a plan view. Forming a concave portion in which the bottom portion is recessed outward at a position facing the mouth portion;
A cylindrical tube supported by the inner wall portion of the housing portion and extending in the height direction of the housing portion is disposed between the concave portion of the housing portion and the mouth portion.
The flask according to any one of claims 1 to 4, wherein the baffle plate is attached to an outer peripheral surface of the cylindrical tube. The flask according to claim 5, wherein the cylindrical tube has an opening end on the mouth side larger in diameter than an opening end on the recess side.

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