JP2010057677A - Biological data processing apparatus, biological data processing method and biological data processing program - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biological data processing apparatus enhancing the reliability, efficiency and safety of an ischemic heart disease by an exercise tolerance test, a biological data processing method and a biological data processing program. <P>SOLUTION: The biological data processing apparatus 100 sets the completion time of loading as the starting point, allows an ST level trend graph before a predetermined time with respect to the completion time of loading to linearly approximate to calculate a straight line and its inclination α and visualizes the calculated straight line and the inclination α in a real time. Concretely, in an exercise loading electrocardiographic system 10, a judge result is displayed on a screen in a real time to be reported. Further, a degree of stricture using only an elapse time and an ST level is illustrated and numeralized in a real time. Furthermore, the judge results in a plurality of electrocardiographic inductions are illustrated and quantified using the inclination. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a biological information processing apparatus, a biological information processing method, and a biological information processing program that display an electrocardiogram measured in an exercise load test.

As an electrocardiogram analysis method for analyzing an electrocardiogram measured in a treadmill exercise load test, for example, there is one described in Patent Document 1. In this method (hereinafter referred to as “Bi-Angle evaluation method”), an ST level of an electrocardiogram is measured every 15 seconds in a treadmill exercise load test, and the measurement result is used as the X axis and the ST level measurement value is expressed as Y level. Plot on the coordinate plane as the axis, find the angle θE between the line connecting the plot point at the end of load and the fifth plot point before the end of load and the X axis, and the plot point at the end of load and after the end of load The angle θR between the line connecting the fifth plot point and the Y axis is obtained, and the product of the two angles θE and θR is calculated (hereinafter, this calculated value is referred to as “Bi-Angle Score”). Diagnosis of ischemic heart disease based on the size of Angle Score.
JP-A-2005-103224

  However, in the above conventional electrocardiogram analysis apparatus, compared with other evaluation methods (for example, ST / HR Slope method, etc.) used before by the Bi-Angle evaluation method, ischemic heart disease. Although it has been described that diagnostic accuracy has been improved, since judgment results are not provided in a timely manner during electrocardiogram analysis, not only low-skilled users but also highly-skilled users can suffer from heart disease. There were certain limits to improving the reliability and efficiency of diagnosis.

  The present invention has been made in view of the above points, and is a biological information processing apparatus, a biological information processing method, and a biological information processing capable of improving the reliability, efficiency, and safety of ischemic heart disease by an exercise load test. The purpose is to provide a program.

  The biological information processing apparatus according to the present invention includes an electrocardiogram measuring unit that measures a plurality of lead electrocardiograms of a subject, and a time axis direction of an ST level of an electrocardiogram waveform that is measured while the subject is loaded with exercise. ST level trend graph visualization means for visualizing changes in ST level in real time as an ST level trend graph, and a straight line obtained by approximating the ST level trend graph a predetermined time before the end of load with a straight line starting from the end of load And the inclination α of the calculated straight line and the inclination α visualization means for visualizing the inclination α in real time.

  The biological information processing method of the present invention includes a step of measuring a plurality of lead electrocardiograms of a subject, a test subject being loaded with exercise, and an ST level change of the ST level of the electrocardiogram waveform measured during the load. Step of visualizing the ST level trend graph in real time, and calculating the straight line and its slope α by linearly approximating the ST level trend graph a predetermined time before the end of the load, starting from the end of the load, Visualizing the calculated straight line and its slope α in real time, calculating a straight line and its slope β by linearly approximating the ST level trend graph after a predetermined time has elapsed since the end of the load, and calculating the straight line And visualizing its slope β.

  From another point of view, the present invention relates to a step of measuring a plurality of lead electrocardiograms of a subject, a test subject being loaded with exercise, and an ST level change of the ST level of the electrocardiogram waveform measured during the load. Step of visualizing the ST level trend graph in real time, and calculating the straight line and its slope α by linearly approximating the ST level trend graph a predetermined time before the end of the load, starting from the end of the load, Visualizing the calculated straight line and its slope α in real time, calculating a straight line and its slope β by linearly approximating the ST level trend graph after a predetermined time has elapsed since the end of the load, and calculating the straight line And a biological information processing program for causing a computer to execute the step of visualizing the inclination β.

  ADVANTAGE OF THE INVENTION According to this invention, the reliability, efficiency, and safety | security of ischemic heart disease by an exercise load test can be improved.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

  FIG. 1 is an external view of an exercise electrocardiogram inspection system according to an embodiment of the present invention. The biological information processing apparatus of the present embodiment is an example applied to an electrocardiogram analysis apparatus that performs a treadmill exercise load electrocardiogram examination.

  In FIG. 1, the exercise load electrocardiogram inspection system 10 includes a biological information processing apparatus 100 and a treadmill 20 as a loading apparatus, and the biological information processing apparatus 100 and the treadmill 20 are connected online by a dedicated cable 30. The

  The biological information processing apparatus 100 includes a biological information processing apparatus main body 100a, a display 40 including an LCD (Liquid Crystal Display), an operation unit 50 including a keyboard and a mouse, a printer 60, and a sphygmomanometer 70. Is done.

  The treadmill 20 monitors the subject with an electrocardiogram, gradually applies an exercise load by walking on the running belt 20a, and confirms changes in the electrocardiogram before and after the load to detect ischemic heart disease (angina , An exercise load device used for examination for determining the presence or absence of myocardial infarction.

  The display 40 displays test information such as an electrocardiogram waveform, a heart rate, a blood pressure value, and an ST level trend on the screen.

  The operation unit 50 is input and set by a doctor or the like for performing an exercise electrocardiogram using a keyboard or a mouse. For example, a doctor inputs an ST level (Bi-Angle evaluation method) trend graph display request command using a keyboard, a mouse, or the like.

  The printer 60 outputs test information such as an electrocardiogram waveform, a heart rate, a blood pressure value, and an ST level trend displayed on the display 40 as a Bi-Angle evaluation report 70A.

  The Bi-Angle evaluation report 70A can display all report items from the doctor to the subject such as findings and waveforms on the display surface (printable surface) of one report sheet.

  The biological information processing apparatus 100 is a PC (Personal Computer) terminal device, and can be typically realized by a general-purpose computer such as a desktop PC.

  FIG. 2 is a block diagram illustrating a configuration of the biological information processing apparatus 100.

  2, the biological information processing apparatus 100 includes a control unit 101, a display interface (hereinafter abbreviated as “I / F”) 102, a printer I / F 103, an electrocardiograph I / F 104, a sphygmomanometer I / F 105, and an input device. An I / F 106 and a storage unit 107 are included. The biological information processing apparatus 100 includes a display 120, a printer 130, and an electrocardiograph via a display I / F 102, a printer I / F 103, an electrocardiograph I / F 104, a sphygmomanometer I / F 105, and an input device I / F 106, respectively. 140, a blood pressure monitor 150, a mouse 161 of a pointing device, and a keyboard 162 are connected.

  The control unit 101 serving as an ST level trend graph visualization means, an inclination α visualization means, an inclination β visualization means, and an inclination product visualization means of the present invention stores a CPU and an electrocardiogram analysis program executed by the CPU. It consists of. The control unit 101 executes the electrocardiogram analysis program to realize a function in the biological information processing apparatus 100 to execute each step in a Bi-Angle evaluation report creation process described later. Each control function of the control unit 101 will be described later.

  The display I / F 102 is an I / F that connects the display 120 and the biological information processing apparatus 100 in a communicable manner. The display 120 has a display screen such as an LCD (Liquid Crystal Display) liquid crystal display, for example, and is connected to the biological information processing apparatus 100 via a connector (not shown).

  The printer I / F 103 is an I / F that connects the printer 130 and the biological information processing apparatus 100 in a communicable manner. The printer 130 has a paper feed mechanism that feeds printing paper and a printing mechanism such as a thermal head type, a laser type, and an ink type that prints on the fed printing paper. Connected to the information processing apparatus 100.

  The electrocardiograph I / F 104 communicatively connects the electrocardiograph 140 that acquires a standard 12-lead electrocardiogram from the subject by the limb electrocardiogram electrode unit 141 and the chest electrocardiogram electrode unit 142 and the biological information processing apparatus 100. Data that is exchanged between the electrocardiograph 140 and the biological information processing apparatus 100 passes through the electrocardiograph I / F 104. Details of the electrocardiograph 140 will be described later.

  The sphygmomanometer I / F 105 is an I / F that communicatively connects a sphygmomanometer 150 that measures blood pressure non-invasively from a subject using an oscillometric method and the biological information processing apparatus 100. Data exchanged with the information processing apparatus 100 passes through the sphygmomanometer I / F 105. The sphygmomanometer 150 detects the pulse wave at the attachment site using the cuff 151 attached to the limb of the subject, for example, the upper arm, and changes the volume of the blood vessel when the force with which the cuff 151 compresses the blood vessel is equal to the average blood pressure. Measure blood pressure by taking advantage of the maximum. Specifically, the sphygmomanometer 150 supplies air to the cuff 151 to compress and drive the attachment site, and then detects the pressure of the cuff 151 while evacuating the pulse wave until the compression force falls below the minimum blood pressure. Acquire the pressure signal superimposed. Then, the pulse wave signal is separated from the pressure signal using a filter, and it is determined that the pressure value of the cuff is equal to the average blood pressure when the maximum amplitude is observed throughout the entire section of the separated pulse wave signal.

  The input device I / F 106 is an interface connected via a USB (Universal Serial BUS) cable as a general-purpose interface, for example. USB is a standard standardized by USB-IF (USB Implementers Forum), and is a serial bus interface that connects the biological information processing apparatus 100 to peripheral devices such as a mouse 161 and a keyboard 162 that is a dedicated key panel.

  The storage unit 107 includes a storage device such as a hard disk drive or a semiconductor storage device. The storage unit 107 stores data input from the control unit 101 as needed. The storage unit 107 stores in advance various data used for drawing a Bi-Angle evaluation report.

[Input Control of Control Unit 101]
The control unit 101 mainly has a CPU, interprets a doctor's input using the mouse 161 or the keyboard 162 as a command by executing an ST level (Bi-Angle evaluation method) trend graph display program, and instructs by the command. Execute the specified process. In this embodiment, only the mouse 161 and the keyboard 162 are illustrated as input devices. However, other input devices such as a touch panel and a pen tablet can be substituted or used together as necessary.

  Here, examples of the input command include the following.

-Import request: Request to import data from the electrocardiograph 140-Display request: Request to display the Bi-Angle evaluation report on the screen of the display 120-Print request: Bi-Angle evaluation on recording paper by the printer 130 Request to print report-Request for analysis: Request to execute analysis function In these commands, patient specifying data (for example, name, identification number, etc.) for specifying a patient is shown as necessary. Therefore, when the doctor uses the mouse 161 or the keyboard 162 to instruct the desired process and the patient to be processed, the control unit 101 displays the patient specifying data of the patient on the screen of the display 120. The process is executed.

  If the desired processing is the display of the Bi-Angle evaluation report on the screen of the display 120 or the printing of the Bi-Angle evaluation report on the recording paper by the printer 130, the doctor can display the Bi-Angle evaluation report or An item to be printed can also be designated, and the control unit 101 also indicates the designated item in the generated display request or print request. Examples of items that can be designated as display items or print items include the following.

First synthetic electrocardiogram: A scalar electrocardiogram showing each waveform of lead I, lead II, lead III, lead aVR, lead aVL and lead aVF is a front view vector ECG (hereinafter simply referred to as “front view”). Electrocardiogram arranged around • Second synthetic electrocardiogram: Horizontal electrocardiogram (hereinafter simply referred to as a horizontal electrocardiogram) showing a scalar electrocardiogram showing each waveform of leads V1, V2, V3, V4, V5 and V6. Electrocardiogram placed around ("Horizontal Plane")-12-lead ECG analysis result-Vector ECG analysis result-Rhythm-guided waveform-3D vector ECG: A vector showing a vector loop viewed from any specified viewpoint or viewing direction ECG ・ Patient data Among the above items, for example, the first and second synthetic ECGs should be automatically displayed as default even if not specified by the doctor. Or shown in the print request, the other items are shown in the display request or print request only when it is specified by the input operation of the physician. Note that the default of the specified item can be changed as appropriate.

[Output Control of Control Unit 101]
The control unit 101 executes a Bi-Angle evaluation method program to display a Bi-Angle evaluation report on the display 120 based on the calculated Bi-Angle evaluation report data, and to cause the printer 130 to print the function. Is realized. Specifically, when the display request is input together with the Bi-Angle evaluation report data, the control unit 101 causes the display 120 to display the electrocardiogram report on the screen, and requests the print with the Bi-Angle evaluation report data. Is input, the printer 130 is made to print the Bi-Angle evaluation report on the recording paper.

  Thereby, drawing of the Bi-Angle evaluation report including the ST level (Bi-Angle evaluation method) is realized.

[Control of medical measuring device of control unit 101]
The control unit 101 is exchanged between a storage device such as a RAM or a ROM for storing a program for controlling communication with various medical measurement devices, a CPU for executing the control program, and a medical measurement device in communication. It mainly has a buffer for temporarily storing data. Various medical measurement devices are connected to the biological information processing apparatus 100 via connectors (not shown) and I / Fs. In the present embodiment, an electrocardiograph 140 and a sphygmomanometer 150 are connected to the biological information processing apparatus 100. The control unit 101 realizes the following functions by executing the control program. That is, the control unit 101 receives an input of a command (import request) requesting to import 12-lead ECG data from the electrocardiograph 140 and transmits it to the electrocardiograph 140. Then, the control unit 101 receives patient data and 12-lead ECG data specified in the import request transmitted from the electrocardiograph 140 in response to the import request. Similarly, the control unit 101 receives an input of a command (import request) for requesting blood pressure import from the sphygmomanometer 150 and transmits it to the sphygmomanometer 150. Then, the control unit 101 receives the blood pressure data of the patient specified in the import request transmitted from the sphygmomanometer 150 in response to the import request. In this way, data import from the electrocardiograph 140 and the sphygmomanometer 150 is realized. The imported data may include attribute data and analysis results by the electrocardiograph 140 in addition to patient data, 12-lead ECG data, and blood pressure data.

  Here, patient data is data for specifying individual patients such as names and identification numbers. The 12-lead ECG data is data including the measurement result of the standard 12-lead method, and is generated by the electrocardiograph 140. Specifically, the electrocardiograph 140 includes an limb electrocardiogram electrode portion 141 having a plurality of electrocardiogram electrodes to be worn on the patient's limbs during electrocardiogram measurement, and a plurality of electrocardiogram electrodes to be worn on the patient's chest during electrocardiogram measurement. Using the electrocardiogram electrode part 142 for the chest with the standard 12 lead method, lead I, lead II, lead III, aVR lead, aVL lead, aVF lead, V1 lead, V2 lead, V3 lead, V4 lead, V5 lead And V6 induction can be measured. In the present embodiment, electrocardiograms of leads II, III, aVF, V4, and V5 among standard 12 lead methods are measured, and digital data representing these measurement results is generated as lead measurement electrocardiogram data. The electrocardiograph 140 stores the generated 12-lead electrocardiogram data in association with patient data in a storage device (not shown) in the electrocardiograph 140.

  The electrocardiograph 140 also stores data associated with individual patients such as age, height, weight, etc. (hereinafter referred to as “attribute data”) in a storage device in the electrocardiograph 140 in association with the patient data. be able to. Further, when the electrocardiograph 140 has an analysis function, the generated 12-lead electrocardiogram data can be analyzed, and the analysis result can also be stored in a storage device in the electrocardiograph 140 in association with the patient data. When the electrocardiograph 140 has a built-in display device or printing device, the electrocardiograph 140 causes the built-in printing device to display a scalar electrocardiogram based on the generated 12-lead electrocardiogram data. In addition, the analysis results can be displayed or printed together with or separately from the scalar electrocardiogram.

  With the various functions of the electrocardiograph 140, the control unit 101 needs attribute data and / or analysis results associated with the patient data together with the patient data of the designated patient and the 12-lead ECG data. Accordingly, it can be received from the electrocardiograph 140.

  When the control unit 101 has a function of detecting the connection between the electrocardiograph 140 and the biological information processing apparatus 100, the control unit 101 voluntarily issues an import request when detecting this connection. May be sent to. Alternatively, the electrocardiograph 140 may start transmitting 12-lead ECG data without transmitting an import request from the control unit 101 to the electrocardiograph 140.

  Further, when an analysis request is input via the input device I / F 106, the control unit 101 stores the 12-lead electrocardiogram data and Bi-angle evaluation report data of the patient specified by the patient specifying data in the analysis request. And the electrocardiogram analysis is performed on the read data, and the result of this analysis processing is stored in the storage unit 107 in association with the patient data.

  In addition, when a display request is input via the input device I / F 106, the control unit 101 stores the 12-lead ECG data and Bi-Angle evaluation report data of the patient specified by the patient specifying data in the display request. Read from. Then, the control unit 101 generates digital data representing the Bi-Angle evaluation report (hereinafter referred to as “Bi-Angle evaluation report data”) based on the read Bi-Angle evaluation report data and 12-lead ECG data. The Bi-Angle evaluation report data includes data about the item specified in the display request. For example, when only the first and second composite electrocardiograms are designated as display items in the display request, the control unit 101 determines the first and second from the 12-lead electrocardiogram data and Bi-Angle evaluation report data of the designated patient. Bi-angle is generated by generating data of the composite electrocardiogram and further editing the data of the first and second composite electrocardiograms so that the first and second composite electrocardiograms are displayed on the screen according to a predetermined format. Generate evaluation report data. The control unit 101 outputs the generated Bi-Angle evaluation report data to the display I / F 102 together with the display request, and the display 120 displays the display request and the generated Bi-Angle evaluation report data.

  In addition, when a print request is input via the input device I / F 106, the control unit 101 stores the 12-lead ECG data and Bi-Angle evaluation report data of the patient specified by the patient specifying data in the print request 107 Read from. And the control part 101 produces | generates Bi-Angle evaluation report data based on the read Bi-Angle evaluation report data and 12-lead ECG data. For example, when only the first and second composite electrocardiograms are specified as print items in the print request, the control unit 101 determines the first and second from the 12-lead electrocardiogram data and the Bi-Angle evaluation report data of the specified patient. By generating data of the composite electrocardiogram and further editing the data of the first and second composite electrocardiograms so that the first and second composite electrocardiograms are printed on a recording sheet according to a predetermined format, Bi- Angle evaluation report data is generated. The control unit 101 outputs the generated Bi-Angle evaluation report data to the printer I / F 103 together with the print request, and the printer 130 prints the print request and the generated Bi-Angle evaluation report data.

  The configuration of the biological information processing apparatus 100 has been described above. In the present embodiment, biological information processing apparatus 100 and electrocardiograph 140 are independent of each other, but they may be integrated.

  Hereinafter, the operation of the biological information processing apparatus 100 configured as described above will be described.

[Operation flow]
First, the operation flow of the biological information processing apparatus 100 and the functions of the biological information processing apparatus 100 will be described.

  1. When there is a suspicion of coronary artery stenosis for a heart disease patient, an exercise electrocardiogram is performed by the biological information processing apparatus 100.

  2. The exercise electrocardiogram inspection by the biological information processing apparatus 100 is classified at rest, during loading, and after loading, and the patient's electrocardiogram and blood pressure are recorded in the load electrocardiogram apparatus as needed.

  During the examination, the biological information processing apparatus 100 displays and reports report examination information such as an electrocardiogram waveform, heart rate, blood pressure value, ST level (Bi-Angle evaluation method) trend graph.

  During the load, the running belt 20a of the treadmill 20 as a loading device moves, and the patient walks or runs for about 10 minutes.

  During the load, the biological information processing apparatus 100 controls the speed and gradient (tilt) of the treadmill 20.

  3. In the ST level (Bi-Angle evaluation method) trend graph during the load, the doctor determines the stop of the load from the straight line and angle indicating the degree of stenosis.

  4). The doctor monitors test information such as an electrocardiogram waveform, a heart rate, a blood pressure value, and an ST level (Bi-Angle evaluation method) trend graph displayed on the screen even after loading for a predetermined (for example, 6 minutes) or more.

  5. The test is terminated after the patient recovers.

  6). After completion of the examination, the biological information processing apparatus 100 displays the examination result (determination of coronary artery stenosis) on a screen and outputs a report, and saves the examination data in an external storage (for example, a hard disk drive) of the biological information processing apparatus 100.

  7). If the determination of coronary stenosis is positive, it is predicted that there is a stenotic lesion in the coronary artery, and cardiac catheterization is performed and coronary angioplasty is performed.

  Here, the biological information processing apparatus 100 is characterized in that the coronary artery stenosis is determined from the relationship between the elapsed time and the ST level by the Bi-Angle evaluation method.

  That is, the above 3. In the load test, it is used to determine the load stop by the Bi-Angle evaluation method of the ST level trend.

  In addition, the above 4. After the load test, the coronary artery stenosis is determined by the ST level trend Bi-Angle evaluation method.

  The operation flow of the biological information processing apparatus 100 has been described above.

[Operation during load test]
Next, the operation during the load test will be described.

  3 and 4 are diagrams showing a display screen of the display 120. FIG. 3 shows the configuration of the load test screen, and FIG. 4 shows the screen during the load test.

  In FIG. 3, the display screen 200 has selection information 211, 212 and a test mode protocol ID number 220 in the upper part of the load test screen 200 </ b> A, and measurement value information 230, average waveforms 241, 242, and current waveform 250 in the middle part. The rhythm waveform 260 and the operation button 270 are provided in the lower stage.

  The selection information 211, 212 is information on the electrocardiogram data selected by the doctor, for example, ST level trend graph, II lead, III lead, aVF lead, V4 lead, and V5 lead waveform.

  The test mode protocol ID number 220 includes a patient's name, ID, examination doctor name, data management information button, and the like.

  The measurement value information 230 includes a stage, a heart rate (bbm), a blood pressure (mmHg), a DP (× 100), and the like.

  The average waveforms 241 and 242 are electrocardiograms of leads II, III, aVF, V4 or V5.

  The current waveform 250 is an electrocardiogram current waveform, and the rhythm waveform 260 is an electrocardiogram heartbeat waveform.

  The operation buttons 270 are various operation buttons including a measurement guide selection button.

  In the load test screen 200A, the selection information 211 and the selection information 212 are juxtaposed on the upper left and right, the average waveforms 241 and 242 and the current waveform 250 are juxtaposed on the middle left and right, and the horizontal lower side of the average waveforms 241 and 242 and the current waveform 250 By arranging the horizontally long rhythm waveform 260 in the part, it is possible to make the report matter fit on one sheet of paper and make it easy to see.

  FIG. 5 is a diagram showing a selection information window opened on the load test screen. This selection information window is opened by right-clicking the mouse 161 with selection information 211 or selection information 212 on the load test screen 200A of FIG.

  As shown in FIG. 5, the selection information window 280 includes a heart rate, blood pressure + DP, VPC, load, average, ST level + ST slope, ST slope (start) + (end), ST integral, ST index, R wave height. , Zone (heart rate + ST level), zone (ST slope + ST level), and ST level (Bi-Angle). In FIG. 5, the ST level (Bi-Angle) is a selection target and is in an active state.

  (1) Right-click the selection information 211 or the selection information 212 with the mouse 161 on the load test screen 200A shown in FIG.

  (2) A selection information window 280 shown in FIG. 5 is displayed.

  (3) From the selection information window 280, select [ST level (Bi-Angle)]. An ST level (Bi-Angle evaluation method) trend graph is displayed in the selection information 211 or the selection information 212 on the load test screen 200A.

  FIG. 4 shows an actual load test screen 200B. The ST level (Bi-Angle evaluation method) trend graph is displayed in the selection information 211 on the load test screen 200B of FIG. 4, and the selection information 212 includes II lead, III lead, and aVF lead among standard 12 lead ECGs. , V4 lead and V5 lead waveforms are displayed. Also, the load test screen 200B of FIG. 4 displays average waveforms 241, 242, current waveform 250, and rhythm waveform 260, as well as test mode protocol ID number 220, measured value information 230, and operation. An example of button 270 is displayed.

  (4) End the load test.

  When the “stop key” on the keyboard 162 or the dedicated key panel is pressed, the load is terminated and the state transitions to recovery.

  Next, the ST level (Bi-Angle evaluation method) trend graph display operation during the load test will be described.

  The biological information processing apparatus 100 displays an ST level (Bi-Angle evaluation method) trend graph during the load test and after the end of the load test described later.

  Here, the ST level (Bi-Angle evaluation method) trend graph during the load test will be described.

  (1) As shown in the selection information 211 of FIG. 4, during the load test, a trend graph of “elapsed time” on the horizontal axis and “ST level” on the vertical axis is displayed.

  (2) ST level (Bi-Angle evaluation method) The ST level at 15-second intervals is plotted on the trend graph.

  (3) After the ST level has changed by 0.1 mV (relative value) or more, the ST level point 90 seconds before (6 points before) and 75 seconds before (5 points before) the latest ST level point is connected by a straight line.

  (4) Display the horizontal axis and the angle (α) of the straight line.

  (5) When the voltage changes by 0.1 mV (relative value) or more, the current average waveform is displayed in a conspicuous color (for example, red).

  (6) The load test is terminated at the discretion of the doctor or engineer depending on the value of the angle (α).

  (7) Even at the time of recovery, the ST level at 15-second intervals is plotted on the ST level (Bi-Angle evaluation method) trend graph.

  (8) At the time of recovery, the ST level point 75 seconds later (after 5 points) from the ST level point at the end of load is connected by a straight line.

  (9) During recovery, the angle (β) between the vertical axis and the straight line is displayed.

  On the load test screen, a plurality of waveforms including ST level (Bi-Angle evaluation method) trend graphs are displayed in real time, that is, substantially simultaneously with the measurement of biological information. More specifically, as soon as the electrocardiogram signal and the pulse wave signal are supplied from the electrocardiograph 140 to the control unit 101 via the electrocardiograph I / F 104, the control unit 101 determines that the control unit 101 is based on the supplied information. Display waveform data for displaying the obtained waveform on the screen is generated and supplied to the display 120 via the display I / F 102. When the display waveform data is supplied, the display 120 displays it on the screen immediately. Thereby, the doctor can visually recognize the ST level (Bi-Angle evaluation method) trend graph in real time. In this case, a straight line indicating the degree of stenosis and its angle (α) are displayed on the display 120 in real time. From the medical point of view that when the stenosis is present, the ST level suddenly drops before the end of the load, and the recovery of the ST level is slow after the end of the load, the ST level suddenly drops before the end of the load. For example, when the angle (α) is steep, an instruction to stop the exercise load can be immediately executed.

  The above is the operation during the load test of the biological information processing apparatus 100.

[Operation after inspection result]
Next, the operation after the inspection result will be described.

  6 and 7 are diagrams showing the display screen of the display 120. FIG. 6 shows the configuration of the inspection result screen, and FIG. 7 shows the Bi-Angle inspection result screen. The same components as those in the load test screens of FIGS. 3 and 4 are denoted by the same reference numerals.

  In FIG. 6, the display screen 200 has various trends 310 and a test mode protocol ID number 220 in the upper part, and measurement value information 230, an inspection result summary 320, and a screen button 330 in the middle part. In the lower stage, a rhythm waveform 260 and operation buttons 270 are provided.

  The various trends 310 are heart rate, ST index, blood pressure + DP, R wave height, VPC zone (heart rate-ST level), load amount zone (ST slope-ST level), average, RR trend, ST level + ST slope, ST slope start + ST slope end and ST integral. Various trends 310 are displayed by the following operations. That is, the ID information input window is opened and a comment input wait state is entered. When the window is closed, various trends 310 can be confirmed as in the basic screen.

  The test mode protocol ID number 220 displays a test mode, a protocol, and an ID number.

  The measurement value information 230 continues to display the heartbeat and blink the heart mark.

  The test result summary 320 displays a list of test result summaries such as test result information, heart rate-STL trend, and MAX-ST corresponding to each button operation of the screen button 330.

The screen button 330 displays the next screen button in a portion below the load amount.
・ Over lead: The over lead screen is displayed.
・ Individual report: Select and output individual reports instead of those set.
Result summary: A result summary is displayed in the area of the inspection result summary 320. FIG. 6 is a screen displayed by the screen button of the result summary. During display, make it a light character and disable it (mask).
Load analysis: The load analysis result is displayed in the area of the inspection result summary 320.
RR analysis: The RR analysis result is displayed in the area of the inspection result summary 320.
Bi-Angle: The Bi-Angle evaluation result is displayed in the area of the inspection result summary 320. The screen displayed by the Bi-Angle screen button will be described later with reference to FIG.
Vector: A vector electrocardiogram is displayed in the area of the test result summary 320.

  As shown in FIG. 7, on the Bi-Angle test result screen 200 </ b> D, various trends 310 display a load zone (ST slope-ST level) 311 for measurement guidance and a heart rate 312. Further, in the area of the inspection result summary 320, measurement guidance Bi-Angle evaluation results 321 and 322 are displayed. In FIG. 7, the Bi-Angle evaluation result 321a and ST level 321b of II induction, and the Bi-Angle evaluation result 322a and ST level 322b of V5 induction are displayed.

  In the case of FIG. 7, the numerical value (α × β) of the Bi-Angle evaluation result 321a of the II induction is 2175, which is higher than the determination value (1500) of the suspicion of stenosis. In order to call attention, the ST level 321b displays 2175 exceeding the judgment value (1500) with a red level meter. On the other hand, the numerical value (α × β) of the V5 lead Bi-Angle evaluation result 322a is 1170 which is lower than the determination value (1500) of suspicion of stenosis, and the ST level 322b displays 1170 with a blue level meter.

  FIG. 8 is a diagram showing a measurement guide selection window opened on the inspection result screen. The measurement guidance selection window is opened by right-clicking each guidance button on the inspection result screen 200C of FIG.

  As shown in FIG. 8, the measurement guidance selection window includes guidance II, guidance III, aVF guidance, V4 guidance, and V5 guidance. In FIG. 8, the V5 lead is a selection target and is in an active state. Initial values are II induction and V5 induction.

  (1) Right-click the selection information 211 or the selection information 212 with the mouse 161 on the load test screen 200A shown in FIG.

  (2) A selection information window 280 shown in FIG. 5 is displayed.

  (3) From the selection information window 280, select [ST level (Bi-Angle)]. An ST level (Bi-Angle evaluation method) trend graph is displayed in the selection information 211 or the selection information 212 on the load test screen 200A.

  FIG. 4 shows an actual load test screen 200B. The ST level (Bi-Angle evaluation method) trend graph is displayed in the selection information 211 on the load test screen 200B of FIG. 4, and the selection information 212 includes II lead, III lead, and aVF lead among standard 12 lead ECGs. , V4 lead and V5 lead waveforms are displayed. Also, the load test screen 200B of FIG. 4 displays average waveforms 241, 242, current waveform 250, and rhythm waveform 260, as well as test mode protocol ID number 220, measured value information 230, and operation. An example of button 270 is displayed.

  (4) End the load test.

  When the “stop key” on the keyboard 162 or the dedicated key panel is pressed, the load is terminated and the state transitions to recovery.

  Next, the ST level (Bi-Angle evaluation method) trend graph display operation after the inspection result will be described.

  The biological information processing apparatus 100 displays an ST level (Bi-Angle evaluation method) trend graph during the above-described load test (FIGS. 3 to 5) and after the end of the load test. The display of the ST level (Bi-Angle evaluation method) trend graph after the inspection result is as follows.

  (1) As shown in the load amount zone (ST slope-ST level) 311 in FIG. 7, after the load test is finished, on the inspection result screen 200C, the trend of “elapsed time” on the horizontal axis and “ST level” on the vertical axis Display the graph.

  (2) The start of the ST level trend is displayed from 0′00 during loading.

  (3) The ST level point at the end of load is the origin.

  (4) The ST level point 5 points before the load end (75 seconds before) is connected and displayed with a straight line (A).

  (5) The origin and the ST level point 5 points after the end of load (75 seconds later) are connected and displayed with a straight line (B).

  (6) The angle (α) between the horizontal axis and the straight line (A) is displayed.

  (7) The angle (β) between the vertical axis and the straight line (B) is displayed.

  (8) Judgment of coronary artery stenosis is performed with values of α, β, and α × β.

  (9) The scale of the level meter is “0 to 6000”. Numbers are displayed as 0.1500, 3000, and 6000.

(10) The determination is “none”, “suspect”, “presence”, and “determination impossible”.
-Judgment ranges are "determination not possible: HR <120 and STL> -0.1 mV", "negative: 0 ≦ α × β <500”, “false positive: 500 ≦ α × β <1500”, “positive: 1500 ≦ α × β ”.

  (11) The determination range will be described later with reference to FIG. For example, the determination range is “undecidable: HR <120 and STL> −0.1 mV”, “negative: 0 ≦ α × β <500”, “false positive: 500 ≦ α × β <1500”, “Positive: 1500 ≦ α × β”.

  (12) A numerical value (α × β) is displayed on the level meter.

  (13) As shown in the ST levels 321b and 322b in FIG. 7, the color of the level meter is determined as “Yes: Red”, “Suspect: Yellow”, and “No: White”.

  (14) The level meter is not displayed when “determination is impossible”.

  (15) “(α × β) 1500” should be clearly understood.

  (16) The ST level is displayed as an absolute value.

  (17) Display the HR and ST levels at the end of control and load.

  The above is the operation after the end of the load test of the biological information processing apparatus 100.

  FIG. 9 is a flowchart showing the ST level (Bi-Angle evaluation method) of the biological information processing apparatus 100. In the figure, S indicates each step of the flow.

  When there is a suspicion of coronary artery stenosis for a heart disease patient, the doctor activates the exercise electrocardiogram system 10 to perform the exercise electrocardiogram. The doctor inputs an ST level (Bi-Angle evaluation method) trend graph display request command using the mouse 161 or the keyboard 162.

  In step S <b> 10, the biological information processing apparatus 100 displays a load test screen on the display 120. For example, as shown in the load test screen 200B of FIG. 4, the selection information 211 displays an ST level (Bi-Angle evaluation method) trend graph, and the selection information 212 includes II guidance, III guidance, aVF guidance, Displays V4 and V5 induction waveforms. In addition, average waveforms 241, 242, current waveform 250, and rhythm waveform 260 are displayed.

  In step S20, the biological information processing apparatus 100 performs various settings / selections. A doctor or the like uses the keyboard 162 or the mouse 161 to select settings for conducting the exercise electrocardiogram examination and measurement guidance.

  In step S30, the biological information processing apparatus 100 acquires the electrocardiogram and blood pressure data of the patient to be analyzed. The exercise electrocardiogram is classified at rest, during loading, and after loading. The biological information processing apparatus 100 performs electrocardiogram data (standard 12 leads obtained from the subject) of the patient at rest, during loading, and after loading. Data indicating the waveform of the electrocardiogram) is acquired from the electrocardiograph 140 via the electrocardiograph I / F 104, and blood pressure data of the patient is acquired from the sphygmomanometer 150 via the sphygmomanometer I / F 105.

  In step S40, the biological information processing apparatus 100 determines whether the exercise electrocardiogram is resting, during loading, or after loading.

  When the exercise electrocardiogram test is resting, the biological information processing apparatus 100 displays test information such as an electrocardiogram, a heart rate, a blood pressure value, and an ST level trend on the screen and prints a report in step S50. Proceed to step S90.

  If the exercise electrocardiogram is being loaded, the biological information processing apparatus 100 operates the traveling belt 20a of the treadmill 20 in step S60 and proceeds to step S70. The biological information processing apparatus 100 controls the speed and gradient (tilt) of the treadmill 20 during loading. The treadmill 20 operates the traveling belt 20a at an appropriate speed and gradient (inclination) under the control of the biological information processing apparatus 100. The patient walks or runs on the running belt 20a of the treadmill 20 for about 10 minutes.

  In step S <b> 70, the biological information processing apparatus 100 displays test information such as an electrocardiogram, heart rate, blood pressure value, and ST level trend on the screen and prints a report during the load, and proceeds to step S <b> 90.

  After the load test of the exercise electrocardiogram test, in step S80, the biological information processing apparatus 100 displays test information such as an electrocardiogram, heart rate, blood pressure value, and ST level trend on the screen after the load test, and prints a report. Then, the process proceeds to step S90.

  In step S90, it is determined whether or not there is a doctor stop instruction by operating the keyboard 162 and the mouse 161.

  If there is no stop instruction from the doctor, the biological information processing apparatus 100 determines whether or not load test data has been acquired in step S100. If load test data has not been acquired, the process returns to step S40 until the load test data is acquired.

  If load test data is acquired in step S100 or if there is a doctor stop instruction in step S90, the process proceeds to step S110. In step S110, analysis is performed based on the product of angles at the ST level, the ST change value, and the heart rate at the end of the load. In step S110, the product of the angle at the acquired ST level, the ST change value, and the heart rate at the end of the load are analyzed, and as a result, findings of coronary artery stenosis are derived. The analyzed data is stored in the storage unit 107 in association with the patient data. In this manner, the control unit 101 of the biological information processing apparatus 100 creates or updates an electrocardiogram database and an ST level (Bi-Angle evaluation method) trend graph for the patient.

  In step S120, the inspection result is displayed on the display screen 200 of the display 120, the Bi-Angle evaluation report 70A (FIG. 1) is printed by the printer 130, and this flow is finished. The findings shown in the findings data, the overview map shown in the Bi-Angle evaluation report 70A, and the ST level (Bi-Angle evaluation method) trend graph are drawn at predetermined positions on the screen or report sheet, respectively. .

  As described above, the Bi-Angle evaluation report 70A is created.

  FIG. 10 is a flowchart showing analysis of Bi-Angle evaluation, and is a detailed flow of step S110 of FIG.

  In step S210, measurement guidance setting is performed.

  In step S220, sampling data is acquired.

  In step S230, a trend graph is created.

  In step S240, analysis is performed.

  In step S250, determination output is performed and the process returns to step S110 in FIG.

  In the above processing flow, each step can be changed and deleted, another step can be added, and the order of the steps can be changed as appropriate.

  Also on the post-load test screen, a plurality of waveforms including ST level (Bi-Angle evaluation method) trend graphs are displayed in real time, that is, substantially simultaneously with the measurement of biological information, as in the case of the on-load screen. The doctor can visually recognize the ST level (Bi-Angle evaluation method) trend graph in real time. In this case, a straight line indicating the degree of stenosis and its angle (β) are displayed on the display 120 in real time. When there is a stenosis, the doctor can visually and immediately know the numerical value that emphasizes the feature that the ST level drops suddenly before the end of the load and the recovery of the ST level is slow after the end of the load by the product of the angle. it can.

  Next, measurement specifications will be described.

  FIG. 11 is a diagram for explaining an ST level (Bi-Angle evaluation method) trend graph. The horizontal axis shows the elapsed time from the end of the load to the end of the load, and the vertical axis shows the ST level value of the ST level point with the end of the load as the origin. The ST level value is folded at the ST level point on the horizontal axis to take an absolute value and has angles α and β.

(1) Measurement guidance
Measure II, III, aVF, V4 and V5 induction. Initial values are II induction and V5 induction.

(2) Sampling data As shown in FIG. 11, ST level values (absolute values) at intervals of 15 seconds are used. The average value excluding the maximum value and the minimum value of the data for 15 seconds is used. A circle indicates a plotted ST level value.

(3) Trend graph After the load test is completed, create a trend graph with “elapsed time” on the horizontal axis and “ST level” on the vertical axis. The scale ratio between the elapsed time and the ST level is 1 (2 min): 1 (0.1 mV).

(4) Angle Reference As shown in FIG. 11, the ST level point at the end of load is set as the origin.

  Draw a straight line (A) between the origin and the ST level point 5 points before the load end (about 75 seconds before).

  Draw a straight line (B) between the origin and the ST level point 5 points after the end of load (about 75 seconds later).

  Let α be the angle between the horizontal axis and the straight line (A).

  Let β be the angle between the vertical axis and the straight line (B).

(5) Judgment of coronary artery stenosis Judgment of coronary artery stenosis is performed with the value of α × β.

  If “α × β ≧ 1500”, there is stenosis.

  When “α × β <1500”, there is no stenosis.

(6) Output judgment The higher numerical value (α × β) is adopted in the specified guidance.

  FIG. 12 is a table showing determination of ST level (Bi-Angle evaluation method) trend graph.

  In the present embodiment, coronary artery stenosis is determined based on the product (α × β) of ST level STL (mV), heart rate HR (rpm), and ST level trend graph of changes during load and recovery. .

  In FIG. 12, when the ST level STL of the change during loading and during recovery is larger than a predetermined level (here, -0.1 mV), the product (α × β) of the ST level trend graph is not added to the determination parameter. Then, it is determined whether or not coronary artery stenosis can be determined / no coronary artery stenosis by comparing a predetermined value (here, 120 rpm) of the heart rate HR. That is, when STL> −0.1 and HR <120, it is determined that coronary artery stenosis cannot be determined, and when STL> −0.1 and HR ≧ 120, it is determined that there is no coronary artery stenosis. Even if STL> −0.1, the product (α × β) of the ST level trend graph angle may be used for the determination. As described above, when STL> −0.1, it is determined that the coronary artery stenosis is not present / cannot be determined without adding the product (α × β) of the ST level trend graph to the determination parameter.

  When ST level STL of change during load and recovery is −0.1 mV or less, comparison of heart rate HR with 120 rpm and comparison of predetermined value of product (α × β) of ST level trend graph angle To determine coronary stenosis. In the case of HR <120, when the product (α × β) of the ST level trend graph is 0 ≦ α × β <500 and 500 ≦ α × β <1500, it is determined that coronary artery stenosis is suspected. In the case of HR <120, it is determined that coronary artery stenosis is present when the product (α × β) of the ST level trend graph angle is 1500 ≦ α × β. Thus, when STL ≦ −0.1 and HR <120, it is determined that the coronary artery stenosis is suspected / coronary artery stenosis is present.

  When the ST level STL of the change during loading and recovery is −0.1 mV or less and HR ≧ 120, the product of the ST level trend graph angle (α × β) is 0 ≦ α × β <500 It is determined that there is no coronary stenosis. When 500 ≦ α × β <1500, it is determined that the coronary artery stenosis is suspected. Further, when 1500 ≦ α × β, it is determined that coronary artery stenosis is present. As described above, when STL ≦ −0.1 and HR ≧ 120, the coronary artery stenosis is determined according to the product of the angles of the ST level trend graph (α × β). If there is coronary artery stenosis, it branches into three.

  In the present embodiment, coronary artery stenosis is determined based on the product (α × β) of ST level STL (mV), heart rate HR (rpm), and ST level trend graph of changes during load and recovery. . The product of angles of the ST level trend graph (α × β) is an important parameter in determining coronary artery stenosis. However, it has been found that a highly accurate determination can be made when the ST level STL and the heart rate HR of the change during load and during recovery are combined, instead of using this alone. For example, only the product of the angle of the ST level trend graph (α × β), when 1500 ≦ α × β, there was coronary artery stenosis, and otherwise, only suspicion of coronary artery stenosis could be determined. On the other hand, in the present embodiment, by comparing the ST level STL of the change during the load and at the time of recovery together with the heart rate HR, not only the suspected coronary artery stenosis / the presence of coronary artery stenosis but also the absence of coronary artery stenosis / coronary artery Suspicion of stenosis / presence of coronary artery stenosis is now possible.

  13 and 14 are diagrams illustrating output examples of the Bi-Angle evaluation report. FIG. 13 (a) shows the trend graph of the II level ST, FIG. 13 (b) shows the ST level, FIG. 13 (c) shows the ST level before and after the end of the load, the angles α, β, and the product (Bi−). (Angle Score) and a level meter are shown respectively. 14A shows a trend graph of the ST level of V5 induction, FIG. 14B shows the ST level, FIG. 14C shows the ST level, angles α, β, and product (Bi−) before and after the end of the load. (Angle Score) and a level meter are shown respectively.

  FIG. 13 and FIG. 14 are Bi-Angle evaluation reports of II lead and V5 lead of the same patient. The resting heart rate (bbm), blood pressure (mmHg), and DP (× 100) are obtained as 70, 134/77, and 150, respectively, and the heart rate (bbm), blood pressure (mmHg), DP ( X100) were obtained as 125, 154/99, and 150, respectively.

  As shown in FIGS. 13 (a) and 13 (c), this patient has an ST level of -0.20 mV at the end of load in induction II. According to the ST level (Bi-Angle evaluation method) trend graph determination table of FIG. 12, HR ≧ 120 is applied at ST level STL ≦ −0.1 mV, and the product (α × β) of the ST level trend graph angle is 2175 corresponds to 1500 ≦ α × β. Therefore, it is determined that there is coronary artery stenosis.

  On the other hand, as shown in FIGS. 14A and 14C, in the V5 induction, the ST level at the end of the load is −0.06 mV. According to the ST level (Bi-Angle evaluation method) trend graph determination table of FIG. 12, HR ≧ 120 is applied at ST level STL> −0.1 mV. The product (α × β) of the angle of the trend graph is 1170, which is smaller than the determination value (1500), but the product of the angle graph (α × β) of the ST level trend graph in this case is arbitrary. If 1170 of the product (α × β) of the ST level trend graph is not applied, it is determined that there is no coronary stenosis in the V5 lead.

  As described above, when different determination results are obtained in the determination of coronary artery stenosis between leads II and V5, the determination result of lead II, which is a worse determination result, is adopted, and it is determined that coronary artery stenosis is present.

  As described above, according to the present embodiment, the biological information processing apparatus 100 starts from the end of load and linearly approximates the ST level trend graph for a predetermined time before the end of load to obtain a straight line and its inclination α. The calculated straight line and its inclination α are visualized in real time. Specifically, in the exercise electrocardiogram inspection system 10, the determination result is displayed on a screen and a report is output in real time. Further, the degree of stenosis using only the elapsed time and the ST level is shown and digitized in real time. Furthermore, in the determination results in a plurality of electrocardiogram inductions, the angle was used for illustration and quantification. Thereby, the doctor can visually recognize the ST level (Bi-Angle evaluation method) trend graph in real time. A straight line indicating the degree of stenosis and its angle (α) are displayed on the display 120 in real time. The doctor can immediately execute an instruction to stop the exercise load when the ST level suddenly drops before the end of the load, that is, when the straight line and its angle (α) are steep.

  In this embodiment, the ST level trend graph after a predetermined time has elapsed from the end of the load is linearly approximated to calculate a straight line and its slope β, and the calculated straight line and its slope β are visualized and calculated. Since the product of the slope α and the slope β is visualized together with the predetermined determination value, a straight line indicating the degree of stenosis together with the angle (α) and the angle (β) are displayed on the display 120 in real time. When there is a stenosis, the doctor can visually and immediately know the numerical value that emphasizes the feature that the ST level drops suddenly before the end of the load and the recovery of the ST level is slow after the end of the load by the product of the angle. it can.

  Therefore, since the determination result is provided in a timely and easy-to-understand manner during electrocardiogram analysis, not only highly skilled users but also less skilled users can trust ischemic heart disease through exercise testing. Efficiency and efficiency can be improved. In particular, from the straight line and angle indicating the degree of stenosis, it is possible to immediately stop the load according to the doctor's findings, and it is possible to improve safety as well as reliability.

  The above description is an illustration of a preferred embodiment of the present invention, and the scope of the present invention is not limited to this. The above description of the configuration and operation of the device is an example, and various modifications and additions to these examples are possible within the scope of the present invention.

  For example, in this embodiment, stenosis is determined from the product of the angle at ST level, the change value, and the heart rate at the end of the load 75 seconds before the end of the load, at the end of the load, and 75 seconds after the end of the load. Moreover, although the ST level at intervals of 15 seconds is plotted, these measurement conditions and measurement intervals are arbitrary. However, since the ST level value varies for each heartbeat, it is preferable to use an average value excluding the maximum value and the minimum value of data for 15 seconds.

  In this embodiment, the names biological information processing apparatus, exercise electrocardiogram inspection system, and biological information processing method are used for convenience of explanation, and an electrocardiogram analysis apparatus, a heart disease determination apparatus, and a coronary artery stenosis determination. Of course, it may be a method or the like.

  Furthermore, each part which comprises the said biological information processing apparatus and the biological information processing method, for example, the kind of treadmill exercise | movement load, the number, the connection method, etc. may be what kind.

  The biological information processing apparatus and the biological information processing method described above are also realized by a program for causing the biological information processing method to function. This program is stored in a computer-readable recording medium.

1 is an external view of an exercise electrocardiogram inspection system according to an embodiment of the present invention. The block diagram which shows the structure of the biological information processing apparatus which concerns on this Embodiment The figure which shows the structure of the load test screen of the display of the biological information processing apparatus which concerns on this Embodiment. The figure which shows the screen during the load test of the display of the biological information processing apparatus which concerns on this Embodiment The figure which shows the selection information window opened by the load test screen of the biological information processing apparatus which concerns on this Embodiment The figure which shows the structure of the test | inspection result screen of the display of the biological information processing apparatus which concerns on this Embodiment. The figure which shows the Bi-Angle test result screen of the display of the biological information processing apparatus which concerns on this Embodiment. The figure which shows the measurement guidance selection window opened by the test result screen of the biological information processing apparatus which concerns on this Embodiment The flowchart which shows ST level (Bi-Angle evaluation method) of the biological information processing apparatus which concerns on this Embodiment The flowchart which shows the analysis of Bi-Angle evaluation of the biological information processing apparatus which concerns on this Embodiment The figure explaining the ST level (Bi-Angle evaluation method) trend graph of the biological information processing apparatus according to the present embodiment The figure which shows the determination of the ST level (Bi-Angle evaluation method) trend graph of the biological information processing apparatus which concerns on this Embodiment as a table | surface. The figure which shows the output example of the Bi-Angle evaluation report of the biological information processing apparatus which concerns on this Embodiment The figure which shows the output example of the Bi-Angle evaluation report of the biological information processing apparatus which concerns on this Embodiment

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Exercise load electrocardiogram inspection system 20 Treadmill 20a Running belt 30 Dedicated cable 40,120 Display 50 Operation part 60,130 Printer 70,150 Blood pressure monitor 100 Biological information processing apparatus 101 Control part 102 Display I / F
103 Printer I / F
104 ECG I / F
105 Sphygmomanometer I / F
106 Input device I / F
107 Storage Unit 140 Electrocardiograph 141 Electrocardiogram Electrode Unit for Limb 142 Electrocardiogram Electrode Unit for Chest 151 Cuff 161 Mouse 162 Keyboard

Claims (10)

An electrocardiogram measuring means for measuring an electrocardiogram of a plurality of leads of the subject;
An ST level trend graph visualization means for applying an exercise to a subject and visualizing in real time the ST level trend graph of the ST level of the electrocardiogram waveform measured during the load;
Starting from the end of the load, calculating the straight line and its slope α by linearly approximating the ST level trend graph a predetermined time before the end of the load, and the slope for visualizing the calculated straight line and its slope α in real time α visualization means,
A biological information processing apparatus comprising:   A straight line and its slope β are calculated by linearly approximating the ST level trend graph after a predetermined time has elapsed from the end of load, starting from the end of the load, and a slope β for visualizing the calculated straight line and its slope β. The biological information processing apparatus according to claim 1, further comprising a visualization unit.   The biological information processing apparatus according to claim 2, further comprising an inclination product visualization unit that visualizes a product of the calculated inclination α and inclination β together with a predetermined determination value. A heart rate acquisition means for acquiring the heart rate of the subject from the measured electrocardiogram waveform;
3. The biological information processing apparatus according to claim 2, wherein the inclination product visualization means visualizes the acquired heart rate of the subject together with the calculated product of the inclination α and the inclination β. Exercise load means for applying exercise to the subject;
The biological information processing apparatus according to claim 1, further comprising stop instruction means for receiving an instruction to stop exercise load from the exercise load means.   The biological information processing apparatus according to claim 1, wherein the inclination α visualization unit displays the calculated straight line and the inclination α on a screen.   The biological information processing apparatus according to claim 1, wherein the inclination α visualization unit prints the calculated straight line and the inclination α on a document. Measuring a plurality of lead electrocardiograms of the subject;
Applying an exercise to the subject and visualizing in real time the ST level trend graph of the ST level of the ECG waveform measured during the load;
A step of linearly approximating the ST level trend graph at a predetermined time before the end of load, calculating a straight line and its inclination α, starting from the end of load, and visualizing the calculated straight line and its inclination α in real time When,
A step of linearly approximating the ST level trend graph after a lapse of a predetermined time from the end of the load to calculate a straight line and its inclination β, and visualizing the calculated straight line and its inclination β. Biological information processing method.   The biological information processing method according to claim 8, further comprising a step of visualizing a product of the calculated inclination α and inclination β together with a predetermined determination value. Measuring a plurality of lead electrocardiograms of the subject;
Applying an exercise to the subject and visualizing in real time the ST level trend graph of the ST level of the ECG waveform measured during the load;
A step of linearly approximating the ST level trend graph at a predetermined time before the end of load, calculating a straight line and its inclination α, starting from the end of load, and visualizing the calculated straight line and its inclination α in real time When,
For causing the computer to execute a step of calculating a straight line and its slope β by linearly approximating the ST level trend graph after a predetermined time has elapsed from the end of the load, and visualizing the calculated straight line and its slope β. Biological information processing program.