JP2010022775A - Stimulus suitability analyzer and program - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a stimulus suitability analyzer and a program which can objectively and adequately determine, evaluate and display the suitability of stimulus applied to a human body by measuring the state of oxygen exchange in the brain. <P>SOLUTION: The stimulus suitability analyzer A includes a probe 1 for heads, a main unit 2 to which optical information detected by the probe 1 for heads is inputted and which performs calculation, control or storing, an input part 3, a display part 4, a printing part 5 and a communication part 6. A control part 10 of the main unit 2 has a calculating part 12 which measures the amount of each of changes in concentration of oxidized hemoglobin and reduced hemoglobin by subjecting the light volume detected by the probe 1 for heads to arithmetic processing by near-infrared spectroscopy, a determination part 13 which determines the suitability of the stimulus for the human body on the basis of the amount of each of changes in concentration of the oxidized hemoglobin and reduced hemoglobin which is measured before and after application of stimulus to the human body, and an evaluation part 14 which evaluates a stimulus applying means on the basis of the result of determination by the determination part 13. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention includes, for example, oral appliances, oral stimulators, mouthpieces, dentures, toothbrushes and other intraoral inserts, contact lenses, glasses, shoes, underwear, belts, exercise equipment and other human body attachments, injection, anesthesia, The present invention relates to a stimulus suitability analysis apparatus and program for judging, evaluating and displaying the suitability of stimuli to a human body given by various stimulus applying means such as gum, perfume (aroma oil), smell, music, lighting equipment, etc. Stimulus compatibility analysis device that takes into account that the oxygen consumption increases or the brain activity adjustment function by activation and sedation works with the change of neural activity according to the predetermined function and role in the brain And the program.

  Conventionally, Hideki Sugawara, one of the present inventor and the present applicant, presses a pot in the mouth or a forehead joint part, etc. to give stimulation to the mouth, thereby stiff shoulders, joint range of motion expansion, correction of facial distortion And the like have been proposed (see Patent Document 1, Patent Document 2, and Patent Document 3).

  In addition to the above mouth stimulators, mouthpieces, dentures, toothbrushes and other mouth-mounted inserts, contact lenses, eyeglasses, shoes, underwear, belts, exercise equipment and other human body-mounted items, injection, anesthesia, gum, perfume (aroma The human body is also stimulated by various stimulus applying means such as oil), odor, music, and lighting equipment (hereinafter referred to as Conventional Example 1).

  In addition, as conventional techniques for analyzing the brain reaction of the human body, for example, a biological input device using an optical biometric method (see Patent Document 4), a fragrance determination method using an electroencephalogram, and a fragrance determination apparatus (see Patent Document 5) ), A technology such as a biological information automatic identification device (see Patent Document 6) that automatically identifies emotions from the brain has been proposed. Moreover, the technique of the evaluation method (refer patent document 7) of the ophthalmic composition which evaluates ophthalmic products from a brain is proposed.

  All of these techniques analyze brain responses based on changes in brain electrical activity and brain hemoglobin (hereinafter referred to as Conventional Example 2).

By the way, the brain works by stimulating the human body, taking some action, performing tasks, and resting and sleeping. Happens.
Regarding the invention relating to this brain classification address, Toshinori Kato, one of the present inventors and the present applicant, has already filed an application (see Japanese Patent Application No. 2006-194357).

  Here, the address for brain classification (the inventor and the applicant refer to the address as the brain address (registered trademark)) refers to a change in nerve activity according to a predetermined function and role in the brain. It is a number assigned separately for each part considering the increase in oxygen consumption and the function of regulating brain activity by activation and sedation.

Regarding the point that oxygen consumption is increased and activated in each part in the brain, and the function of regulating brain activity by activation and sedation is performed, for example, the present inventors and the present applicant Various parameters derived from the relationship between the amount of change in oxidized hemoglobin and the amount of change in reduced hemoglobin (for example, Patent Document 8 and Patent Document 9) proposed by Toshinori Kato who is one person It is known that recognition can be performed based on the degree of oxygen exchange (k angle), oxygen exchange ratio (k ratio)), hemoglobin exchange amount (L value), a trajectory on a two-dimensional or three-dimensional diagram, and the like.
JP 2003-164507 A Japanese Patent No. 3202980 Japanese Patent No. 3199236 Japanese Patent No. 3543453 JP 2002-282231 A Japanese Patent No. 2766456 JP 2005-319053 A Japanese Patent No. 4031438 International Publication No. 2006/009178

Conventional Example 1 has the following problems.
(1) For the human body, for example, stimulation by mouth stimulators, belt tightening, eyeglass compatibility, mouthpiece discomfort, damage during dental treatment, presence or absence of anesthetic effect, discomfort in the oral cavity after dental treatment , Discomfort and discomfort caused by pain from vaccination, discomfort to smell, comfort, comfortable volume such as music, visual glare with lighting equipment, touch of underwear, feeling of wearing shoes, etc. are exactly the same Even if it is a material, a product, or an attachment, there are many different things such as different impressions, feels, and pain levels depending on the individual.
It is difficult for others to understand and solve the situation of each individual person as much as the person himself.

  It was possible to listen to his claim carefully.

  (2) The fact that jigs installed in the oral cavity give a sense of incongruity, pain, or concern about the effects of the jigs, other than the method of knowing them through their own complaints after wearing them. Could not be judged objectively.

  In addition, the jig could not be adjusted by quantitatively judging discomfort, comfort and discomfort. To that end, everything has been done with the appeal of the wearing side and the skill of the wearing side.

  Conventionally, for example, the evaluation was psychologically based on the SD method in only 5 levels from 1 to 5 or 10 levels from 1 to 10, and lacked objectivity.

  Even when using NIRS (Near-Infrared Spectroscopy), the degree of change varies from person to person and the measurement area is not constant.

  (3) The effect of the wearing tool and the foreign object sensation may become apparent later over time. In such a case, after a few days, the mounting of the mounting tool had to be adjusted again, which was troublesome.

  (4) Even with the same type of wearing equipment, there are individual differences, and each time it was necessary to listen carefully to the individual's declaration and judge and adjust it.

  In such a case, the relationship between the person's complaint and the wearing device is not necessarily in a corresponding relationship. In such a case, it could happen that it didn't work because of too much complaint.

  (5) There was no intraoral device that intentionally activated and sedated the brain. As a result, even if it was acting on the brain, it was unimaginable.

(6) There was no device that could divide the action on the right and left brains, not the action on the whole brain, and effectively activate, relax, and soothe local brain address.
(7) Since the relevance to the action on brain classification addresses such as appliances, food, gum, mouthpieces, toothbrushes, and gum massages to be installed in the oral cavity was unknown, it was intentionally and effectively selected In particular, the local action of the brain could not be controlled.

  For this reason, it was not possible to accurately create a device having an effect on the physiological mechanism of the brain.

  (8) By activating and relaxing the brain as hypoxia, hyperoxygenation at the brain division address, or increase or decrease of blood flow, increase or decrease of blood volume, There was no brace that could control the brain address.

  (9) In brain rehabilitation, a brain disorder may be selectively activated or sedated depending on the patient, even though there are a wide variety of impaired brain classification addresses. It wasn't done. For this reason, the brain rehabilitation was poor in the selectivity of the brain classification address.

  Conventional Example 2 has the following problems.

  (10) Even if optical measurement from the brain is used, only changes such as increase and decrease in oxidized hemoglobin and reduced (deoxidized) hemoglobin can be obtained. In conventional optical measurement analysis, the characterization is ambiguous. It was. As a result, even if these changes were monitored, it was far from being able to immediately judge emotional changes, psychological states, stress states, pain, relaxation, etc. from the data.

(11) Although various parts of the brain, that is, brain classification addresses, share the functions, it is difficult to analyze the functional characteristics of the brain classification addresses, which are brain parts, only with the electroencephalogram. In addition, the meaning of alpha waves and theta waves was difficult.
The present invention has been made to solve the above-mentioned problems, and by measuring the oxygen exchange state of the brain, it is possible to objectively and accurately determine, evaluate, and display the suitability of a stimulus given to the human body. It is an object of the present invention to provide a possible stimulus compatibility analysis apparatus and program.

The stimulus suitability analysis apparatus of the present invention is a stimulus suitability analysis apparatus for analyzing suitability of a stimulus given to a human body by a stimulus applying means.
A light irradiation means for irradiating a predetermined part of the human brain with light;
Light detecting means for detecting light emitted from the human body;
Calculating means for measuring the amount of change in concentration of each of oxidized hemoglobin and reduced hemoglobin by performing a calculation process in the near-infrared spectroscopy on the amount of light detected by the light detection means;
Display means for displaying results measured by the calculation means over time;
Determination means for determining suitability of the stimulus to the human body based on a change that occurs in each measured amount of change in the concentration of oxidized hemoglobin and reduced hemoglobin before and after giving a stimulus to the human body,
Evaluation means for evaluating the stimulus applying means based on a determination result by the determination means;
It is characterized by having.

The calculation means calculates a parameter derived from the relationship between the measured concentration changes of oxidized hemoglobin and reduced hemoglobin, and the determination means calculates the stimulus based on the change in the calculated parameter. It is also possible to determine the suitability of the human body.
The display means converts the first coordinate indicating the relationship between the concentration change amount of the oxidized hemoglobin and the concentration change amount of the reduced hemoglobin and / or the first coordinate by inclining by 45 degrees to change the oxygen saturation level. An oxygen exchange coordinate including a second coordinate indicating the relationship between the change amount and the concentration change amount of total hemoglobin may be displayed.
The display means may display the measurement vector from the origin to the measurement point while displaying the event on the oxygen exchange coordinate by dividing the event into 8 equal parts every 45 degrees.
The parameter may be an oxygen exchange degree (k angle) defined by an angle between a measurement vector from an origin to a measurement point and an axis of change of the oxygen saturation in the oxygen exchange coordinates. .
The parameter may be an oxygen exchange amount (L value) defined by a distance of a measurement vector from an origin to a measurement point.
The determination unit may determine suitability of the stimulus to the human body based on a change in an event where the measurement vector is located before and after applying a stimulus to the human body.
The light irradiating means irradiates light to a plurality of brain classification address parts, the light detection means detects light emitted for each part of the brain classification address, and the calculation means includes the brain Measure the concentration variation of oxidized hemoglobin and reduced hemoglobin for each part of the classification address, and add, subtract, integrate or divide the combined vector created for each part of the brain classification address Vector synthesis means for creating may be provided, and the display means may display the created synthesized vector.

The vector synthesizing means of the calculating means includes a left brain synthesized vector obtained by adding a measurement vector created for each part of the brain classification address of each left brain, and a part of the brain classification address of each right brain A right brain composite vector obtained by adding the measurement vectors created every time may be created.
The vector synthesizing unit of the calculating unit may create a synthesized vector obtained by adding or subtracting the left brain synthesized vector and the right brain synthesized vector.

The stimulus applying means may apply a stimulus to the human body through one of sight, smell, taste, hearing, touch, somatic sensation, movement, or a combination thereof.
In order to stimulate the left and right brains separately, the stimulus applying means covers one ear, one eye, closes one nasal cavity, smells it, right and left eyeballs, nose, ears, hands, feet, body The human body may be stimulated through either the left or right of the trunk, hearing, or touch, or a combination thereof.
The stimulus applying means may be configured such that the oxygen consumption increases or a brain activity adjusting function by activation and sedation functions at a specific brain section address.
The stimulus applying means may be an intraoral mounting device having a lip mounting part to be mounted on the lips and a palate mounting part integrally provided at the base end of the lip mounting part and mounted to the palate.
The stimulus applying means may be a pressurizing device that pressurizes the extremities of a human body and adjusts the stimulus to the left and right brains.
The evaluation unit may create training information for performing training using the stimulus applying unit based on a determination result by the determination unit.

The program of the present invention is a program for analyzing the suitability of a stimulus applied to a human body by a stimulus applying means, and is detected by a light detecting means for irradiating a predetermined part of the human brain and detecting light emitted from the human body. The amount of light emitted is subjected to calculation processing in near-infrared spectroscopy, thereby measuring the concentration variation of each of oxidized hemoglobin and reduced hemoglobin, and the measured results are displayed over time on the display. And a process for determining the suitability of the stimulus to the human body based on changes occurring in the measured concentration change amounts of the oxidized hemoglobin and reduced hemoglobin before and after applying the stimulus to the human body. And a process of evaluating the stimulus applying means based on the determination result.
A process for calculating a parameter derived from the relationship between the measured concentrations of oxidized hemoglobin and reduced hemoglobin, and the suitability of the stimulus to the human body is determined based on the change in the calculated parameter. Processing may be executed by a computer.

According to the present invention, the following excellent effects can be obtained.
(1) The human brain is active by consuming oxygen, and the consumed oxygen is quickly supplied from the artery to the capillaries. According to the present invention, it is possible to objectively and accurately determine, evaluate, and display the suitability of the stimulus given to the human body that has been conventionally regarded as the subjectivity of each individual person by measuring the oxygen exchange state of the brain. It becomes possible to do.
(2) Since it is possible to objectively and accurately understand and evaluate various stimuli caused by intraoral wearing devices, glasses, perfumes, etc., the material for the stimulus imparting means so as to provide a more comfortable sensation for each person. And the shape can be adjusted and selected.

(3) Since it is possible to reduce the burden on the brain by utilizing stimulus applying means such as an intraoral wearing device, it becomes possible to control the relaxation and activation of the brain.
(4) Since the oxygen exchange coordinates and measurement vector can be displayed on the display unit, monitoring can be visually judged at a glance even if the state of pleasant discomfort and discomfort to the stimulus is a plurality of channels (measurement points). By doing so, it is possible to quantitatively determine pleasure, discomfort, and discomfort.
(5) Because it is possible to know the shape of the mounting jig and the effect of the mounting site on the brain classification address, it is possible to selectively activate the brain classification address and control attention such as studying. Become.

(6) It can be seen that the increase / decrease in blood pressure due to increased blood cells and the increase / decrease in oxygen consumption due to increase / decrease in neuronal activity are mathematically regulated in the same equation by the oxygen exchange wave equation,
From the method of displaying the trajectory of the oxygen exchange coordinates, the blood pressure and the activation state of nerve cells can be determined at a glance.
(7) From the quadrant interpretation based on the oxygen exchange coordinates, changes in cell activity and blood pressure can be quantitatively determined as measurement vectors.
(8) The suitability of the stimulus can be comprehensively determined by calculating and synthesizing the sum, difference, product, and divisor of the measurement vectors at a plurality of brain section addresses.

(9) By changing the shape of the intraoral device and the mounting stimulation site in the oral cavity, it is possible to adjust and select the appropriate shape and mounting site while watching the action on the brain classification address in real time on the display unit. .
(10) By separately stimulating the right and left brains, the left and right brains can be distinguished and trained.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
(Configuration of stimulus compatibility analyzer)
FIG. 1 is a block diagram illustrating a configuration of a stimulus suitability analysis apparatus according to an exemplary embodiment of the present invention.

  A stimulus suitability analysis apparatus according to an embodiment of the present invention is an apparatus that analyzes suitability of a stimulus given to a human body by measuring the oxygen exchange state of a subject's brain using near infrared spectroscopy. is there.

Stimulus imparting means for stimulating the human body of the subject gives stimulation to the human body through one of the five human senses of sight, olfaction, taste, hearing, touch, somatosensory, movement, or any combination thereof. Is.
In addition, it is desirable that the stimulus applying means is configured to increase the oxygen consumption or to adjust the brain activity by activation and sedation at a specific brain section address.

  Here, the case where the stimulus is given to the human body by the stimulus imparting means is not limited to the case where the stimulus is intentionally given to the human body like a mouth stimulator, and the result is that the stimulus is given to the human body without intention. It is also included. In the embodiment of the present invention, an intraoral wearing device K is used as an example of the stimulus applying means (see FIG. 2).

  As shown in FIG. 1, a stimulus suitability analyzer A according to an embodiment of the present invention inputs a plurality of head probes 1 and light information detected by the head probes 1, and calculates and controls them. Alternatively, it includes a main body 2 that performs storage, an input unit 3, a display unit 4, a printing unit 5, and a communication unit 6.

  Each head probe 1 interacts with the human body, such as a light emitting element 1a (light emitting diode) that irradiates light to a measurement region (tissue) of the human head, and transmitted light, reflected light, or scattered light from the measurement region. It is comprised with the light receiving element 1b (photodiode) which light-receives after having performed.

  The main body 2 includes a light amount adjusting unit 7 that adjusts the amount of light emitted from the light emitting element 1a, a signal amplifying unit 8 that can amplify a signal from the light receiving element 1b, and an A / A that digitizes the output of the signal amplifying unit 8. D conversion unit 9, control unit 10 that executes predetermined calculation processing based on control processing of each unit and output of A / D conversion unit 9, output of A / D conversion unit 9, control data or calculation of each unit And a storage unit 11 used for storing results and the like.

The control unit 10 performs a calculation process in the near-infrared spectroscopy on the amount of light detected by the head probe 1, thereby calculating a concentration change amount of each of oxidized hemoglobin and reduced hemoglobin; A determination unit 13 for determining the suitability of the stimulus to the human body based on changes in the respective concentration change amounts of oxidized hemoglobin and reduced hemoglobin measured before and after giving a stimulus to the human body, and a determination unit And an evaluation unit 14 that evaluates the stimulus applying means based on the determination result by 13.
The input unit 3 inputs various data such as the subject's profile information and physical information (for example, age, sex, height, weight, dominant hand), and is a keyboard, a numeric keypad, a mouse, or the like.
The display unit 4 is a display for displaying various data.
The printing unit 5 is a printer or the like that prints various data.
The communication unit 6 transmits and receives various data for connecting to a communication network such as the Internet (a data transfer network based on TCP / IP (Transmission Control Protocol / Internet Protocol)) and a LAN (Local Area Network). Modem, terminal adapter, router, DSU (Digital Service Unit), etc.

(Oral appliance)
2A to 2D are plan views illustrating an example of an intraoral wearing device.
The intraoral wearing device K (K1) is made of, for example, an elastic synthetic resin such as silicon, and as shown in FIG. 2A, the upper lip mounting portion 15 to be mounted on the upper lip and the upper lip mounting portion 15 And a palate mounting portion 16 that is mounted on the palate, and is mounted so that the front upper teeth are sandwiched between the upper lip mounting portion 15 and the palate mounting portion 16. A pair of projecting portions 15 a and 15 b are formed at the tip of the upper lip mounting portion 15 with a space left and right.
In addition, as shown in FIG. 2B, an intraoral wearing device K2 in which a part of the upper lip mounting part 15 and a part of the palate mounting part 16 are cut may be used.

  In the upper and lower jaws of the human body, the upper jaw is fixed to the maxilla, whereas the lower jaw has a function of intentionally biting and closing, and the action of the intraoral wearing device K on the brain is different. . Since innervation is divided between the right and left sides of the oral cavity, the effects on the brain are also different.

  Therefore, in order to distinguish the left and right effects of the upper lip mounting portion 15, for example, the intraoral mounting device K3 (see FIG. 2C) with the left projection 15b cut or the intraoral mounting device K4 with the right projection 15a cut ( 2D) may be used.

  In addition, you may use the intraoral mounting device formed exclusively for front tooth mounting, the intraoral mounting device formed only for back tooth mounting, etc.

(Attached part)
FIGS. 3A to 3D are explanatory views schematically showing a state in which the intraoral mounting devices K1 to K4 are respectively mounted on the central portion (median) of the upper jaw T1.

  FIG. 4A is an explanatory diagram schematically showing a state in which the intraoral wearing device K3 is attached to the back part of the right upper jaw T1, and FIG. 4B is a back part of the left upper jaw T1. Explanatory drawing which shows the state with which it was mounted | worn schematically, (C) is explanatory drawing which shows the state with which the intraoral mounting | wearing apparatus K3 was mounted | worn in the site | part of the left lower jaw T2, and (D) is intraoral mounting It is explanatory drawing which shows the state which mounted | wore the back part of the right lower jaw T2 with the instrument K4 roughly.

  FIG. 5 is an explanatory view schematically showing a state in which the intraoral wearing device K1 is attached to the central portion (midline) of the lower jaw T2.

(Measurement site)
6 is an explanatory diagram in which a brain classification address is attached to a two-dimensional view of the brain viewed from directly above, and FIG. 7A is an explanatory diagram in which a brain classification address is attached to a three-dimensional diagram of the left brain viewed from the front side. (B) is explanatory drawing which attached the address for brain division to the three-dimensional figure which looked at the right brain from the front side.

  The brain works by stimulating the human body, taking some action, performing tasks, resting and sleeping, and activating and sedating nerve activity at each brain segment address. . Regarding the invention relating to this brain classification address, Toshinori Kato, one of the present inventors and the present applicant, has already filed an application (see Japanese Patent Application No. 2006-194357).

  Here, the address for brain classification (the inventor and the applicant refer to the address as the brain address (registered trademark)) refers to a change in nerve activity according to a predetermined function and role in the brain. It is a number assigned separately for each part considering the increase in oxygen consumption and the function of regulating brain activity by activation and sedation.

  The measurement site irradiated with light from the light emitting element 1a of the head probe 1 is the brain segment address shown in the frame of FIG. 7A, and is the Broadman 6 field, 4 field, 11 in the frontal lobe. It corresponds to the field, 10 fields, 46 fields, 45 fields, 44 fields, and 6 fields.

  The brain classification address No. 4 is a motor area and issues a command to move the body in each part. Brain classification address 6 is also called the pre-exercise cortex and is thought to be related to exercise planning and planning. The brain classification address 10 is an area related to thinking.

The brain classification addresses 46, 45, 44, and 6 in the left brain are areas related to language, and the contralateral brain classification addresses are areas related to non-language tasks such as graphic operations. It is.
In particular, the brain classification addresses 10, 11, and 9 are areas that vary sensitively to changes in emotion, emotion, pain, pain, and emotion.

  Therefore, it is preferable to install a plurality of head probes 1 so as to include the frontal lobe, in particular, the brain section addresses 10, 11, and 9.

(Calculation of changes in concentration of oxidized hemoglobin and reduced hemoglobin)
The light emitting element 1a of the head probe 1 is prepared in two types, one that emits light with a wavelength of 730 nm and one that emits light with a wavelength of 850 nm. These are arranged alternately, for example, in the column direction. However, when considering other patterns, the arrangement should be such that the amount of received light can be measured in a balanced manner in consideration of the attenuation depending on the wavelength in the tissue. is important. All the light emitting elements 1a are connected to the light amount adjusting unit 7 of the main body 2, and the light emission amount can be adjusted as a whole or independently.

  On the other hand, all the light receiving elements 1b are connected to the signal amplifying section of the main body 2, and the light receiving signals output from the respective light receiving elements 1b are output to the signal amplifying section 8 where they are amplified. The amplified received light signal is digitized by the A / D converter 9 and output to the controller 10.

  The control unit 10 performs noise removal processing by applying digital data input from the A / D conversion unit 7 to a low-pass filter, and then stores the processing data (hereinafter referred to as “light reception amount”) in the storage unit 11 in a time table. Remember.

Moreover, the control part 10 performs the arithmetic processing demonstrated below based on the obtained received light quantity. First, the absorbance at a wavelength of 730 nm (OD ₇₃₀ ) is calculated from (Equation 1), the absorbance at a wavelength of 850 nm (O.D. ₈₅₀ ) is calculated from (Equation 2), and the calculation results are calculated in a timetable manner. Is stored in the storage unit 11.

O.D. ₇₃₀ = log ₁₀ (I _{0 730} / I ₇₃₀ ) (Formula 1)
OD = ₈₅₀ = log ₁₀ (I ₀₈₅₀ / I ₈₅₀ ) (Formula 2)
I _{0 730} : Light emission amount at a wavelength of ₇₃₀ nm I ₇₃₀ : Light emission amount at a wavelength of ₇₃₀ nm I _{0 850} : Light emission amount at a wavelength of 850 nm I ₈₅₀ : Light reception amount at a wavelength of 850 nm Here, the concentration change amount of oxidized hemoglobin and the concentration of reduced hemoglobin It is known from known theory that there is a relationship of (Equation 3) and (Equation 4) between the change amount and the absorbance change amount.

ΔO.D. ₇₃₀ = a ₁ Δ [HbO ₂ ] + a ₁ 'Δ [Hb] (Formula 3)
ΔO.D. ₈₅₀ = a ₂ Δ [HbO ₂ ] + a ₂ 'Δ [Hb] (Formula 4)
ΔO.D. ₇₃₀ : Change in absorbance at a wavelength of ₇₃₀ nm ΔOD. ₈₅₀ : Change in absorbance at a wavelength of 850 nm Δ [HbO ₂ ]: Change in concentration of oxidized hemoglobin Δ [Hb]: Change in concentration of reduced hemoglobin a ₁ , a ₁ ′, a ₂ , a ₂ ′: Absorbance coefficient Accordingly, (Expression 5) and (Expression 6) are obtained from this known simultaneous equation.

Δ [HbO ₂ ] = a {ΔO.D. ₇₃₀ − (a ₁ ′ / a ₂ ′) ΔO.D. ₈₅₀ } (Expression 5)
Δ [Hb] = a (a ₂ / a ₂ ′) {(a ₁ / a ₂ ) ΔO.D. ₈₅₀ −ΔO.D. ₇₃₀ } (Expression 6)
a = a ₂ ′ / (a ₁ a ₂ ′ −a ₁ ′ a ₂ ) ≈1 (1 or its neighboring value)

Therefore, after obtaining the absorbance change amount (ΔOD. ₇₃₀ ) at a wavelength of ₇₃₀ nm and the absorbance change amount (ΔO.D. ₈₅₀ ) at a wavelength of 850 nm, the concentration change amount (Δ [HbO ₂ ]) of oxidized hemoglobin is obtained. Then, the concentration change amount (Δ [Hb]) of reduced hemoglobin is calculated according to (Expression 5) and according to (Expression 6), and the calculation result is stored in the storage unit 11 in a timetable manner.
Note that the amount of change in total hemoglobin concentration (Δ [total-Hb]) is expressed by (Expression 7).

Δ [total-Hb] = Δ [HbO ₂ ] + Δ [Hb] (Expression 7)
The concentration change amount (Δ [ScO ₂ ]) of the oxygen saturation is expressed by (Expression 8).

Δ [ScO ₂ ] = Δ [HbO ₂ ] −Δ [Hb] (Equation 8)

(Oxygen exchange orthogonal vector and oxygen exchange matrix)
FIGS. 8A and 8B are explanatory diagrams showing definitions of an oxygen exchange orthogonal vector and an oxygen exchange matrix.
The diamagnetic oxidized hemoglobin and the paramagnetic reduced (deoxidized) hemoglobin differ in physical properties as a magnetic material. These two hemoglobins also change the wave nature due to the change in magnetism depending on the presence or absence of binding to oxygen molecules. Total hemoglobin is given by the addition of oxidized hemoglobin and reduced hemoglobin.
When the change in total hemoglobin (tHb) is treated as a vector, it is represented by the vector component of the change in oxidized hemoglobin and the change in reduced hemoglobin. The oxidized hemoglobin vector [HbO ₂ ] and the reduced hemoglobin vector [Hb] can be regarded as orthogonal vectors.
The vector orthogonal to the total hemoglobin vector is the oxygen saturation vector [ScO ₂ ], which is expressed by subtracting the [Hb] vector from the [HbO ₂ ] vector (see FIG. 8A).

From the relationship shown in FIG. 8A, it can be seen that the [HbO ₂ ] vector and the [Hb] vector are orthogonal vectors and column vectors. The [tHb] vector and the [ScO ₂ ] vector are orthogonal vectors and column vectors (see FIG. 8B).

The vectors consisting of the four axes [ScO ₂ ], [tHb], [Hb], and [HbO ₂ ] take positive and negative values, respectively. Therefore, by dividing the positive and negative vectors, eight oxygen exchange orthogonal vectors In combination, coordinates on the oxygen exchange plane (referred to as oxygen exchange coordinates in this specification) can be determined.

(About oxygen exchange coordinates)
FIG. 9 is an explanatory diagram for explaining oxygen exchange coordinates.
As shown in FIG. 9, in the oxygen exchange coordinates, the change amount Δ [HbO ₂ ] of oxidized hemoglobin is set on the X axis (horizontal axis), and the change amount Δ [Hb] of reduced hemoglobin is set on the Y axis (vertical axis). a first polar (orthogonal coordinates), a first polar rotated 45 degrees, X 'axis (DerutaSc0 ₂ axes) oxygen saturation variation in capillary [ScO _2], Y' axis (? THb The second polar coordinates (orthogonal coordinates) with the axis) as the concentration change [tHb] of total hemoglobin. Note that a time axis may be added to the above two-dimensional coordinates and displayed in three-dimensional coordinates.

  Moreover, as shown in FIG. 9, in the oxygen exchange coordinates, the event can be divided into 8 equal parts every 45 degrees (quadrant I to quadrant VIII).

Here, when the vector direction is [ScO ₂ ]> 0, which separates quadrant I and quadrant VIII, oxygen metabolism decreases in the cell, and the amount of consumption is less than that of supplied oxygen. In the state where the oxygen concentration is increasing, it is determined that the cell activity of the brain classification address at the measurement site is decreased or decreased.

On the other hand, when the vector direction is [ScO ₂ ] <0, which separates quadrant IV and quadrant V, oxygen metabolism is increased in the cell, and the amount of consumption is larger than the supplied oxygen. In the state where the concentration is lowered, it is determined that the cell activity of the brain classification address at the measurement site is increased, increased or decreased.

  When the vector direction divides quadrant II and quadrant III [tHb]> 0, there is no change in the level of cell activity, but there is an increase in red blood cells in the capillaries, and for the brain segmentation of the measurement site The local blood pressure at the address rises and is determined to be in a stress (tension) state.

  On the other hand, when the vector direction divides quadrant VI and quadrant VII [tHb] <0, there is no change in the level of cell activity, but there is no change in the level of red blood cells in the capillaries. The local blood pressure at the sorting address decreases, and it is determined to be in a relaxed state.

Thus, the meaning of each of the eight quadrants from quadrant I to quadrant VIII, that is, the quadrant effect, is defined as follows by combining the four vector directions of [ScO ₂ ] and [tHb].

  In quadrant I, the relationship of decreased cell activity> increased blood pressure> 0 holds.

  In quadrant II, the relationship of increased blood pressure> reduced cell activity> 0 holds.

  In quadrant III, the relationship of increased blood pressure> increased cell activity> 0 holds.

  In quadrant IV, the relationship of increased cell activity> increased blood pressure> 0 holds.

  In quadrant V, the relationship of increased cell activity> decreased blood pressure> 0 holds.

  In quadrant VI, the relationship of decreased blood pressure> increased cell activity> 0 holds.

  In quadrant VII, the relationship of decreased blood pressure> reduced cell activity> 0 holds.

In quadrant VIII, the relationship of decreased cell activity> reduced blood pressure> 0 holds.
Thus, the quadrant of the oxygen exchange coordinate can be used as a reference for immediately determining a phenomenon in which brain cell activity is regulated by oxygen consumption, oxygen supply, and increase or decrease in local cerebral blood pressure. Thereby, the determination unit 13 can objectively and accurately determine the suitability of the stimulus to the human body based on the change in the event where the measurement point is located before and after applying the stimulus to the human body. .

10 to 13 are explanatory diagrams showing the compatibility between the time series data of [Hb] and [HbO ₂ ] and the time series data of [ScO ₂ ] and [tHb] corresponding to each quadrant change. is there.
As can be seen from FIGS. 10 to 13, the time series data of [Hb] and [HbO ₂ ] and the time series data of [ScO ₂ ] and [tHb] are at first glance replaced as fluctuations in eight quadrants. be able to.

FIG. 14 is a schematic diagram for explaining the blood cell fluctuation in the capillary blood vessels and the activity of the nerve cells. As shown in FIG. 14, at an arbitrary point 0 of the capillary blood vessel, oxygen molecules are moved in the direction perpendicular to the increase / decrease direction of the [tHb] vector even in the actual anatomy. That is, oxygen exchange is performed in the direction of 90 degrees in the direction of blood cell progression. Therefore, the [ScO ₂ ] vector representing the oxygen exchange and the [tHb] vector are orthogonal to each other.

  As blood velocity increases, red blood cells increase, capillary blood pressure increases, and the [tHb] vector becomes positive. When blood velocity decreases, red blood cells decrease, intracapillary blood pressure decreases, and the [tHb] vector becomes negative.

  When nerve cell activity increases, oxygen transfer vectors from the capillaries to the cells are generated. On the other hand, when nerve cell activity decreases, oxygen is not taken up by the cells, and a passing vector is generated toward the vein side.

  In this way, it can be seen that the increase or decrease in blood pressure due to increase in blood cells and the increase or decrease in oxygen consumption due to increase or decrease in neuronal activity are mathematically regulated in the same equation by the oxygen exchange wave equation. From the display of the locus on the coordinates, the blood pressure and the activation state of the nerve cell can be determined at a glance.

(Calculation of parameters)
The calculation unit 12 can calculate a parameter derived from the relationship between the measured concentration changes of oxidized hemoglobin and reduced hemoglobin.
The determination unit 13 can determine the suitability of the stimulus to the human body based on the change in the parameter calculated by the calculation unit 12.

As the parameter, for example, the oxygen exchange degree (k angle) and the oxygen exchange amount (L value) used in the biological function diagnostic apparatus proposed by the present inventor and one of the present applicants, Toshinori Kato are used (Patent Literature). 8 and Patent Document 9).
It is also possible to use other parameters.
FIG. 15 is an explanatory diagram for explaining the oxygen exchange degree (k angle) and the oxygen exchange amount (L value).

(About the degree of oxygen exchange (k angle))
As shown in FIG. 15, the degree of oxygen exchange (k angle) is the right angle of 45 degrees around the origin, with the change amount of oxidized Hb as the X axis and the change amount of reduced Hb as the Y axis. The measurement vector A1 from the measurement origin to the measurement point and the X ′ axis in the polar coordinates where the oxygen saturation change amount is the X ′ axis and the total Hb change amount is the Y ′ axis. The angle between them.
FIG. 16 is a graph schematically showing the relationship between capillaries and veins and the degree of oxygen exchange. As shown in FIG. 16, the capillary blood vessel has a high degree of oxygen exchange (k angle), and the vein has a low k angle. Therefore, it is possible to extract capillary dominant data having a high k angle.

The passing vector on the oxygen exchange coordinate can be defined as the oxygen exchange degree 0, and the oxygen transfer vector as the oxygen exchange degree π or -π. Depending on the degree of increase / decrease of red blood cells in the [ScO ₂ ] vector, the value of the degree of oxygen exchange can take an analog value.
Since oxygen exchange does not occur in the artery and vein, the degree of oxygen exchange is zero. The change in the degree of oxygen exchange accurately measures the oxygen exchange in the capillaries.

(Oxygen exchange amount (L value, scalar))
As shown in FIG. 15, the oxygen exchange amount (L value) refers to the distance of the measurement vector A1 from the measurement origin to the measurement point.

  The magnitude of the L value represents the strength of the effect in the quadrant. When a specific stimulus is not given, the oxygen exchange amount L value is small.

The L value representing the wave amplitude in the wave function ψ is also expressed as a scalar composed of the [HbO ₂ ] vector and the [Hb] vector. Alternatively, it is expressed as a scalar composed of a [tHb] vector and a [ScO ₂ ] vector. Depending on the time from the start of stimulation to the brain, when the degree of oxygen exchange is high in the capillary phase, an increase in the amount of hemoglobin exchange means a strong FORCE effect. On the other hand, an increase in the amount of hemoglobin exchange at a low oxygen exchange degree shows a Watering effect (see Patent Document 8 and Patent Document 9 for a description of the FORCE effect and the Watering effect).

(Example of determination using L value)
FIGS. 17A to 17C are graphs for explaining the case where the determination unit 13 determines the suitability of the stimulation by the intraoral-mounted device K for the human body using the L value.
The calculation unit 12 determines the influence of wearing / inserting from the average L value (L0 value) at rest shown in FIG. 17 (A) and the average L value (La value) during wearing shown in FIGS. 17 (B) and (C). The value HE ratio (HE ratio = La / L0) is calculated.

  The determination unit 13 determines that the insertion / mounting effect is large when the calculated HE ratio ≧ 1 (see FIG. 17C), and determines that the insertion / mounting effect is small when the HE ratio <1. (See FIG. 17B).

If you want to set the level so that you do not feel uncomfortable, adjust the HE ratio to be 1 or less.
As described above, the determination unit 13 quantitatively compares the resting state and the wearing state using the calculated L value, to the presence or absence of wearing of the jig, to the frontal lobe brain classification address. Can be determined.

  18 to 20 (A) are graphs showing time-series changes in Hb change before and during wearing the intraoral wearing device K, and FIGS. 18 to 20 (B) correspond to oxygen exchange coordinates. It is the graph displayed on. In addition, in the graph of FIGS. 18-20A, the time-sequential change until 200 seconds after mounting | wearing of the intraoral mounting | wearing apparatus K is displayed with time.

  In FIG. 18, the change at rest fluctuates and fluctuates in the range surrounded by ○, but even if it is worn, it stays within ○ without departing from the range of ○. "Type" pattern.

  For the subject having this pattern, the determination unit 13 determines that the subject is worn in a natural state without any sense of incongruity.

In addition, if this pattern is recognized even when a strong pain stimulus is applied, it indicates that the influence of pain does not affect the corresponding brain classification address.
In FIG. 19, the change due to wearing has a large L value, and movement to quadrants VII and VIII is recognized, which is a “relaxation reaction type” pattern.
For the subject having this pattern, the determination unit 13 determines that the subject is in a comfortable and relaxed state.

  In FIG. 20, the change due to wearing has a large L value and movement to quadrants II and III is recognized, which is a pattern of “tension response type”.

  For the subject with this pattern, the determination unit 13 determines that there is pain or discomfort.

  In addition, the determination unit 13 can also determine that the activation of the brain section address has increased as the K angle increases.

  As described above, since the above three reaction types can be easily determined by using the oxygen exchange coordinates, the degree of relaxation and tension are optimized while observing the movement on the oxygen exchange coordinates displayed on the display unit 4. The stimulus applying means (for example, the intraoral wearing device K) can be adjusted as follows.

  Moreover, the determination part 13 can also determine immediately whether the test subject is accustomed to the stimulus by the stimulus applying means by confirming that the transition to the no-response pattern shown in FIG.

(Display of oxygen exchange coordinates and measurement vector)
21A to 21C are examples in which measurement results at a plurality of brain section addresses are displayed as oxygen exchange coordinates and measurement vectors. FIG. 21D is a measurement vector of (A) to (C). This is an example in which a combined vector obtained by adding is displayed.

  The calculation unit 12 includes a synthetic vector creation unit that creates a composite vector obtained by adding, subtracting, integrating, or dividing a plurality of measurement vectors created for each part of the brain classification address, and the display unit 4 is created A composite vector can be displayed.

  Even if different reactions occur at a plurality of measurement sites, the trend of the entire brain can be immediately determined by using a combined (summation) vector obtained by adding the measurement vectors.

  That is, since a plurality of brain section addresses are linked to each other while performing different brain reactions, it may be insufficient to evaluate individual brain section addresses alone.

  Therefore, as a method of comprehensively evaluating cerebral physiological phenomena that are linked to each other while different brain reactions occur in different brain classification addresses, which is the sum of the measurement vectors of the multiple brain classification addresses? It can be determined by indicating the quadrant.

  For example, if the sum of the vectors from address 9 to address 11 indicates quadrant IV or quadrant V, it can be seen that, as a whole, oxygen consumption increases and cell activity is thriving.

  On the other hand, if quadrant VII or quadrant VIII is shown, even if there is partial cell activity, it is understood that the cell activity is in a relaxed state as a whole. Alternatively, it can be determined that some of the addresses for brain classification were in the cell active state while the cell activity was lowered as a whole.

  FIG. 22A is an example in which the measurement results at a plurality of brain segment addresses in the left brain are displayed with oxygen exchange coordinates and measurement vectors, and FIG. 22B shows the measurement results at a plurality of brain segment addresses in the right brain. It is an example displayed with exchange coordinates and a measurement vector, (C) is an example displaying a combined vector obtained by adding the measured vector of (A), and (D) is a combined vector obtained by adding the measured vector of (C). Is an example.

  As shown in FIGS. 2 (C) and 2 (D), when the left and right asymmetric intraoral wearing devices K3 and K4 are inserted into the subject's mouth, as shown in FIGS. 22 (C) and 22 (D), It can be seen that the composite vector indicates different directions and causes different actions. In this way, it is possible to determine that the action on the left brain and the right brain is different by displaying the composite vector for each of the left and right brain division addresses.

  That is, the human brain is divided into a right brain and a left brain, the functions of the left brain are mainly responsible for language functions, and the functions of the right brain are mainly responsible for non-language functions. .

  It is possible to easily compare the brain activity states of the right brain and the left brain by summing the vectors of the right brain and the left brain.

  For example, in FIG. 22, it is impossible to determine which quadrant is dominant unless the sum is obtained (see FIGS. 22A and 22B). However, by summing up, the left brain is determined to be quadrant II (see FIG. 22C) and the right brain is determined to be quadrant VIII (see FIG. 22D), so that the state of brain activity in the left and right brains is completely different. You can see that it was different. That is, the determination unit 13 determines that the right brain is in a state in which the cell activity is gradually decreasing while the blood pressure of the left brain is increased.

  FIG. 23A is an example in which a composite vector obtained by adding measurement vectors at a plurality of brain segment addresses in the left brain is displayed, and FIG. 23B is a composition obtained by adding measurement vectors at a plurality of brain segment addresses in the right brain. (C) is an example of displaying a vector obtained by adding the combined vector of (A) and the combined vector of (B), and (D) is an example of (B) from the combined vector of (A). This is an example of displaying a vector obtained by subtracting the combined vector of

By taking the sum or difference of the left and right brain addresses, it is possible to determine the trend of the entire brain or the difference in action on the left and right brains.
In other words, the state of the entire brain can be determined by taking the sum of the vectors of the right and left brain brain classification addresses.

For example, as shown in FIG. 23C, the sum of the vectors of the right brain and the left brain shows quadrant I.
From this, the cell activity of the brain classification address at the measurement site is reduced in a state where the oxygen metabolism in the cell is reduced, the consumption is less than the supplied oxygen, and the oxygen concentration in the capillary is increased. Is determined to be decreased or decreased.

  On the other hand, by taking the vector difference between the right brain and the left brain address for brain classification, the comparison between the left brain and the right brain is quantitatively determined by the vector amount and the quadrant. For example, as shown in FIG. 23 (D), the vector difference between the right brain and left brain segmentation addresses indicates quadrant VII. In quadrant VII, the relationship between the blood pressure at the brain section address> the decrease in the cell activity at the brain section address> 0 holds, so the difference in blood pressure at the brain section address is much greater than the difference in cell activity between the left and right brains. It can be determined that it is strong.

  FIG. 24 (A) is an example displayed with the oxygen exchange coordinates and the measurement vector measured before the subject wears and adjusts the intraoral wearing device K, and (B) shows the oxygen exchange measured after the adjustment. It is an example displayed with coordinates and measurement vectors.

  As shown in FIG. 24 (A), since the subject was in pain when wearing the intraoral wearing device K, the measurement vector indicated quadrant II, but by adjusting the shape, material, etc., FIG. As shown in B), it can be seen that the L value and the K angle have decreased and moved to quadrant VIII.

  As described above, the jig can be adjusted in real time so as to give an optimal stimulus to each subject while observing the movement of the measurement vector locus of the oxygen exchange coordinates on the display unit 4.

FIG. 25 (A) is an example displayed with the oxygen exchange coordinates and measurement vector measured when the subject lifts the 7 kg dumbbell without wearing the intraoral wearing device K, and (B) shows the subject's oral cavity. It is an example displayed with the oxygen exchange coordinates and measurement vector measured when the 7 kg dumbbell is lifted after mounting the internal mounting device K, and (C) is the difference between the measurement vector of (A) and the measurement vector of (B). It is the example which displayed the vector which shows.
As shown in FIG. 25A, in the dumbbell exercise without wearing the intraoral wearing device K, quadrant III was shown.

  However, as shown in FIG. 25 (B), it can be seen that the L value and the k angle are decreased and moved to the quadrant II by the mounting of the intraoral mounting device K.

  As shown in FIG. 25C, when the difference between the measurement vectors before and after the intraoral wearing device K is installed, quadrant VII is shown, and the intraoral wearing device K reduces the burden on the brain and relaxes. We can see that we were able to create

  In addition, according to the present invention, intraoral stimulators, mouthpieces, dentures, toothbrushes and other intraoral inserts, contact lenses, glasses, shoes, underwear, belts, exercise equipment and other human body attachments, injection, anesthesia, gum, The human body through one of the five senses of sight, smell, taste, hearing, touch, somatic sensation, movement, or a combination thereof, by means of applying stimuli such as perfume (aroma oil), smell, music, lighting equipment, etc. It is possible to determine and display the suitability of various stimuli applied to the.

(About the Evaluation Department)
The evaluation unit 14 is based on the determination result of the suitability of the stimulus by the determination unit 13, whether the stimulus applying means is optimal, whether the shape or material should be adjusted, or changed to another stimulus applying means Can be created and displayed on the display unit 4.

  The evaluation unit 14 can also create training information for performing training using the stimulus applying unit based on the determination result of the suitability of the stimulus by the determination unit 13 and display the training information on the display unit 4. The training information is, for example, advice information such as a specific method and schedule for performing training using the intraoral-mounted device K.

(Effect of training using intraoral appliances)
Based on the analysis result by the stimulus suitability analysis apparatus of the present invention, training is performed using the intraoral-mounted device K as the stimulus applying means, thereby providing the following effects.
(1) Recognize effects used at rest and effects used during activities.
(2) When resting, sleepy or dull, it is possible to recover energy by increasing fresh blood to the anterior cortex. As a preparatory exercise that uses the superfrontal area intensively before studying or starting work, it can be preliminarily activated with an oral appliance instead of thinking.

(3) It is possible to soothe brain sorting addresses that have been overused and tired.
(4) Even without a conversation that can be stimulated and trained by selectively stimulating the brain division address where brain metabolism is reduced due to cerebral infarction, frontal lobe blurring, aphasia, etc. Rehabilitation of sorting addresses can be promoted.

(5) In patients with cerebral infarction, the disorder varies depending on the brain classification address, such as a right brain disorder and a left brain disorder. It can act on these parts.
(6) When carrying a heavy load at the time of activity, it is possible to reduce the additional oxygen consumption at the address for the motor system brain classification, thus saving energy at the motor system address. As a result, the brain is less tired than when it is not worn. The mobility of movement of limbs can be improved.
(7) It is possible to stimulate a part related to the balance and positional relationship of the trunk.
(8) When thinking or being nervous, the resulting blood flow and blood volume in the frontal lobe are likely to increase, but by using the intraoral device K, the brain section address is sedated, Can alleviate the burden.
That is, there are effects such as reducing the oxygen load on the brain, making the body easier to move, having a heavier thing, and accelerating the recovery effect of the brain.

(program)
FIG. 26 is a block diagram showing the configuration of another embodiment of the present invention. As shown in FIG. 26, another embodiment of the present invention controls the stimulus suitability analysis apparatus A according to the embodiment of the present invention, and performs the processing performed by the stimulus suitability analysis apparatus A described above as a computer. It relates to the program 17 to be executed. The program 17 may be recorded on a recording medium such as a magnetic disk, a CD-ROM, or a semiconductor memory, or may be downloaded via a communication network.

(Pressure device)
FIG. 27A is a block diagram showing an example in which a stimulus suitability analyzer according to an embodiment of the present invention is connected to a pressurizing device for applying a stimulus to the brain, and FIG. It is a graph which shows the result of having measured the amount of change of each Hb for every channel (a number shows a channel) at the time of pressurizing the right arm with an apparatus.

  As shown in FIG. 27 (A), the pressurizing device 18 as a stimulus applying means for applying a stimulus to the brain may be connected to the stimulus suitability analyzing device A according to the embodiment of the present invention. Good. The pressurizing device 18 is a device that pressurizes the extremities of a human body and adjusts stimulation to the left and right brains. For example, a manchette similar to a sphygmomanometer is wound around the arm and pressed.

By pressing the arm muscles with the pressurizing device 18, the brain on the opposite side of the arm can be hypoxic. That is, by controlling the compression pressure from the peripheral nerve, the presence / absence and extent of the FORCE effect occurring in the center can be displayed, and the function of the cerebrovascular state can be determined.
For example, FIG. 27B is a graph showing the results of measuring the amount of change in each Hb for each channel (the number indicates the channel) when the right arm is pressurized by the pressure device.
As shown in FIG. 27B, it can be seen that hypoxia occurs in the left brain.

(Effect of the present invention)
According to the stimulus compatibility analysis apparatus A and the program 17 according to the present invention, the following effects can be obtained.
(1) It is possible to objectively and accurately determine whether or not there is an effect of causing a sense of incongruity, pain, or concern by stimulation of a jig or the like attached to the oral cavity.
Furthermore, the jig can be adjusted or selected by quantitatively determining a sense of discomfort, comfort or discomfort. Thereby, the wearing side and the wearing side can be determined by a common quantitative standard.

  (2) Even with the same type of wearing device, individual differences can be determined from the person's brain information and used.

(3) It is possible to provide a stimulus applying means for activating and sedating the brain.
(4) By attaching to the left and right of the frontal lobe, it is not an action that affects the entire brain, but the adjustment of the device that can effectively activate, relax, and soothe local brain segment addresses Is possible.
(5) Devices such as appliances, foods, gums, mouthpieces, toothbrushes, gum massages, etc. to be worn in the oral cavity can be selected intentionally and effectively from the local action of the brain according to the purpose. .

(6) It is possible to accurately create a device that has an effect on the physiological mechanism of the brain.
(7) Stimulation imparting means such as an intraoral device K that can control hypoxia, hyperoxygenation, increase or decrease in blood flow, increase or decrease in blood volume, and activation and relaxation of the brain from the brain section address. Can be provided.
(8) In the brain rehabilitation, the brain section address can be selectively activated or sedated by the stimulus applying means such as the intraoral wearing device K.

  Although the brain tissue in the address for cerebral infarction that has become a focal point of cerebral infarction has been destroyed, blood circulation is not sufficient in the surrounding cerebral address, so through a stimulus applying means such as an intraoral wearing device K Can stimulate the brain section address around the cerebral infarction.

  It has been reported that language function is localized in the human left brain with a probability of nearly 90%.

A cerebral infarction does not necessarily damage the left brain. In this case, the function recovery training of the contralateral right brain can be appropriately promoted by the stimulus applying means such as the intraoral wearing device K.
(9) The stimulus applying means such as the intraoral wearing device K can be adjusted by the display unit while monitoring the influence of the left and right sides of the brain.
(10) When measurement is simultaneously performed on a plurality of channels, it is possible to select and determine which channel value is valid, and at the same time, it is possible to simultaneously grasp the trend of the entire measurement region.
(11) The action time on the brain can be changed by measuring the part of the address for brain division and changing the usage time. In addition, the activation time and rest time can be controlled.

  The present invention is not limited to the above-described embodiments, and various modifications can be made within the scope of the technical matters described in the claims.

  The present invention includes, for example, oral appliances, oral stimulators, mouthpieces, dentures, toothbrushes and other intraoral inserts, contact lenses, glasses, shoes, underwear, belts, exercise equipment and other human body attachments, injection, anesthesia, It is used to determine / evaluate and display the adaptability of stimuli to the human body given by various stimulating means such as gum, perfume (aroma oil), smell, music, lighting equipment and the like.

It is a block diagram which shows the structure of the stimulus compatibility analysis apparatus which concerns on the example of embodiment of this invention. (A)-(D) are top views which show an example of an intraoral mounting device. (A)-(D) is explanatory drawing which shows roughly the state which each mounted | wore intraoral mounting apparatus K1-K4 to the site | part of the center part (midline) of the upper jaw. (A) is explanatory drawing which shows the state which mounted | wore the back part of an upper right jaw with the intraoral mounting device K3 schematically, (B) is the state which mounted | wore the back part of the left upper jaw with the intraoral mounting device K4. (C) is an explanatory view schematically showing a state in which the intraoral mounting device K3 is mounted on the back part of the left lower jaw, and (D) is an explanatory diagram schematically showing the intraoral mounting device K4 in the right lower jaw. It is explanatory drawing which shows the state mounted | worn in the site | part of the back of FIG. It is explanatory drawing which shows schematically the state which mounted | wore the intraoral mounting | wearing instrument K1 in the site | part of the center part (midline) of the lower jaw. It is explanatory drawing which attached the address for brain division to the two-dimensional figure which looked at the brain from right above. (A) is an explanatory diagram in which a brain classification address is attached to a three-dimensional view of the left brain viewed from the front side, and (B) is an explanatory diagram in which a brain classification address is attached to a three-dimensional diagram of the right brain viewed from the front side. (A) And (B) is explanatory drawing which shows the definition of an oxygen exchange orthogonal vector and an oxygen exchange matrix. It is explanatory drawing for demonstrating an oxygen exchange coordinate. Corresponding to each quadrant change is an explanatory view showing a compatibility with the time series data of [Hb] and [HbO _2] and time-series data of [ScO _2] and [tHb]. Corresponding to each quadrant change is an explanatory view showing a compatibility with the time series data of [Hb] and [HbO _2] and time-series data of [ScO _2] and [tHb]. Corresponding to each quadrant change is an explanatory view showing a compatibility with the time series data of [Hb] and [HbO _2] and time-series data of [ScO _2] and [tHb]. Corresponding to each quadrant change is an explanatory view showing a compatibility with the time series data of [Hb] and [HbO _2] and time-series data of [ScO _2] and [tHb]. It is a schematic diagram for demonstrating the blood cell fluctuation | variation in a capillary blood vessel, and the activity of a nerve cell. It is explanatory drawing for demonstrating an oxygen exchange degree (k angle) and oxygen exchange amount (L value). 3 is a graph schematically showing the relationship between capillaries and veins and the degree of oxygen exchange. (A)-(C) are the graphs for demonstrating the case where the determination part 13 determines the adaptability with respect to the human body of the irritation | stimulation by the intraoral mounting device K using L value. (A) is a graph which shows the time-sequential change of Hb change before mounting | wearing with the intraoral mounting | wearing apparatus K, and (B) is the graph displayed on the oxygen exchange coordinate corresponding to it. (A) is a graph which shows the time-sequential change of Hb change before mounting | wearing with the intraoral mounting | wearing apparatus K, and (B) is the graph displayed on the oxygen exchange coordinate corresponding to it. (A) is a graph which shows the time-sequential change of Hb change before mounting | wearing with the intraoral mounting | wearing apparatus K, and (B) is the graph displayed on the oxygen exchange coordinate corresponding to it. (A)-(C) is an example which displayed the measurement result in the address for several brain divisions by the oxygen exchange coordinate and the measurement vector, (D) adds the measurement vector of (A)-(C). This is an example in which the synthesized vector is displayed. (A) is an example in which the measurement results at a plurality of brain segment addresses in the left brain are displayed in oxygen exchange coordinates and measurement vectors, and (B) is the measurement result at a plurality of brain segment addresses in the right brain. (C) is an example of displaying a combined vector obtained by adding the measurement vector of (A), and (D) is a combined vector obtained by adding the measured vector of (C). This is an example. (A) is an example of displaying a combined vector obtained by adding measurement vectors at a plurality of brain section addresses in the left brain, and (B) is a combined vector obtained by adding measurement vectors at a plurality of brain section addresses in the right brain. (C) is an example of displaying a vector obtained by adding the combined vector of (A) and the combined vector of (B), and (D) is a combined vector of (A) and (B). It is the example which displayed the vector which subtracted the vector. (A) is an example displayed with the oxygen exchange coordinates and measurement vector measured before the subject wears and adjusts the intraoral wearing device K, and (B) is the oxygen exchange coordinates measured after the adjustment and It is an example displayed with a measurement vector. (A) is an example displayed with the oxygen exchange coordinates and measurement vector measured when the subject lifts the 7 kg dumbbell without wearing the intraoral wearing device K, and (B) is the subject wearing the oral cavity. It is an example displayed with oxygen exchange coordinates and a measurement vector measured when a 7 kg dumbbell is lifted after the appliance K is mounted, and (C) shows the difference between the measurement vector of (A) and the measurement vector of (B). This is an example of displaying a vector. It is a block diagram which shows the structure of the other embodiment of this invention. (A) is a block diagram showing an example in which a stimulus compatibility analyzer according to an embodiment of the present invention and a pressurizing device for applying a stimulus to the brain are connected; It is a graph which shows the result of having measured the amount of change of each Hb for every channel (a number shows a channel) at the time of pressurizing a right arm.

Explanation of symbols

A: Stimulus compatibility analysis device K: Intraoral wearing instrument 1: Head probe 1a: Light emitting element 1b: Light receiving element 2: Main body 3: Input part 4: Display part 5: Printing part 6: Communication part 7: Light quantity adjustment Unit 8: signal amplification unit 9: A / D conversion unit 10: control unit 11: storage unit 12: calculation unit 13: determination unit 14: evaluation unit 15: upper lip mounting unit 16: palate mounting unit 17: program 18: pressurization apparatus

Claims (18)

In a stimulus suitability analysis apparatus that analyzes suitability of a stimulus given to a human body by a stimulus applying means,
A light irradiation means for irradiating a predetermined part of the human brain with light;
Light detecting means for detecting light emitted from the human body;
Calculating means for measuring the amount of change in concentration of each of oxidized hemoglobin and reduced hemoglobin by performing a calculation process in the near-infrared spectroscopy on the amount of light detected by the light detection means;
Display means for displaying results measured by the calculation means over time;
Determination means for determining suitability of the stimulus to the human body based on a change that occurs in each measured amount of change in the concentration of oxidized hemoglobin and reduced hemoglobin before and after giving a stimulus to the human body,
Evaluation means for evaluating the stimulus applying means based on a determination result by the determination means;
A stimulus suitability analyzing apparatus characterized by comprising:   The calculation means calculates a parameter derived from the relationship between the measured concentration changes of oxidized hemoglobin and reduced hemoglobin, and the determination means calculates the stimulus based on the change in the calculated parameter. The stimulus suitability analysis apparatus according to claim 1, wherein suitability for the human body is determined.   The display means converts the first coordinate indicating the relationship between the concentration change amount of the oxidized hemoglobin and the concentration change amount of the reduced hemoglobin and / or the first coordinate by inclining by 45 degrees to change the oxygen saturation level. 3. The stimulus compatibility analysis apparatus according to claim 1, wherein oxygen exchange coordinates including a second coordinate indicating a relationship between the change amount and the concentration change amount of total hemoglobin are displayed.   4. The stimulus adaptation according to claim 3, wherein the display unit displays the measurement vector from the origin to the measurement point on the oxygen exchange coordinates by dividing the event into 8 equal parts every 45 degrees. Sex analysis device.   The parameter is an oxygen exchange degree (k angle) defined by an angle between a measurement vector from an origin to a measurement point and an axis of change of the oxygen saturation in the oxygen exchange coordinates. 5. The stimulus compatibility analysis apparatus according to claim 4, wherein   6. The stimulation suitability analysis apparatus according to claim 4, wherein the parameter is an oxygen exchange amount (L value) defined by a distance of a measurement vector from an origin to a measurement point.   The determination means determines suitability of the stimulus to the human body based on a change in an event in which the measurement vector is located before and after applying a stimulus to the human body. The stimulus compatibility analysis device according to any one of the above. The light irradiating means irradiates light to each of a plurality of brain section addresses,
The light detection means detects light emitted for each part of the brain section address,
The calculating means measures the concentration change amount of each of oxidized hemoglobin and reduced hemoglobin for each part of the brain section address, and adds, subtracts a measurement vector created for each part of the brain section address, A vector synthesis means for creating a synthesized vector obtained by integration or division;
The stimulus compatibility analysis apparatus according to any one of claims 4 to 7, wherein the display unit displays the created composite vector.   The vector synthesizing means of the calculating means includes a left brain synthesized vector obtained by adding a measurement vector created for each part of the brain classification address of each left brain, and a part of the brain classification address of each right brain 9. The stimulus suitability analysis apparatus according to claim 8, wherein a right brain composite vector obtained by adding the measurement vectors created every time is created.   10. The stimulus suitability analysis apparatus according to claim 9, wherein the vector synthesis means of the calculation means creates a synthesized vector obtained by adding or subtracting the left brain synthesized vector and the right brain synthesized vector.   11. The stimulus applying means according to claim 1, wherein the stimulus applying means gives a stimulus to the human body through one of sight, smell, taste, hearing, touch, somatosensory, movement, or a combination thereof. Stimulus suitability analysis device according to item.   2. The stimulus applying means applies a stimulus to a human body through left and right eyeballs, nose, ear, hand, foot, trunk, hearing, touch, left and right, or a combination thereof. The stimulation suitability analysis apparatus according to any one of Items 11 to 11.   The stimulating means is configured to increase the oxygen consumption at a specific brain classification address, or to function to adjust brain activity by activation and sedation. The stimulus suitability analysis apparatus according to any one of claims 1 to 12.   The stimulus applying means is an intraoral mounting device having a lip mounting part to be mounted on a lip and a palate mounting part integrally provided at a proximal end of the lip mounting part and mounted to a palate. The stimulation suitability analysis apparatus according to any one of claims 1 to 13.   The stimulus adaptation according to any one of claims 1 to 13, wherein the stimulus applying means is a pressurizing device that pressurizes the extremities of a human body and adjusts the stimulus to the left and right brains. Sex analysis device.   The said evaluation means produces the training information for performing training using the said stimulus provision means based on the determination result by the said determination means, The any one of Claims 1 thru | or 15 characterized by the above-mentioned. Stimulus compatibility analysis device. In a program for analyzing the suitability of a stimulus given to a human body by a stimulus applying means,
Oxygenated hemoglobin and reduction are performed by applying light to a predetermined part of the human brain and detecting the amount of light detected by the light detection means for detecting the light emitted from the human body. A process for measuring the concentration variation of each type hemoglobin,
A process of displaying the measured result on the display unit over time;
A process for determining suitability of the stimulus to the human body based on a change that occurs in each measured concentration change amount of the oxidized hemoglobin and reduced hemoglobin before and after giving a stimulus to the human body;
A process of evaluating the stimulus applying means based on the determination result;
A program that causes a computer to execute.   A process for calculating a parameter derived from the relationship between the measured concentrations of oxidized hemoglobin and reduced hemoglobin, and the suitability of the stimulus to the human body is determined based on the change in the calculated parameter. The program according to claim 17, which causes a computer to execute the processing.

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