JP2010000100A - Biooptical measuring apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an apparatus to measure the function of a salivary gland by biooptical measurement. <P>SOLUTION: The biooptical measuring instrument includes light measuring means to irradiate the vicinity of the salivary gland of a subject with light and receive reflected or transmitted light, signal processing means to draw a change in the salivary gland's function as a signal waveform of a blood substance concentration change when the light stimulates the subject on the basis of a measurement signal received by the light measuring means, and display means to display the result of processing of the signal processing means. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a device (biological light measurement device) that irradiates a human body with light, measures light reflected or scattered inside the human body close to the surface (hereinafter also referred to as biological light), and measures a biological function.

  A biological light measurement device is a device that detects light passing through a living body using visible to near-infrared light and non-invasively measures a biological function (for example, Patent Documents 1 and 2). In recent years, light is irradiated from multiple positions using optical fibers, the light intensity passing through the living body is measured at multiple detection points, and the light intensity information of a relatively wide area including these detection points is obtained to respond to brain activity. A biological light measurement device that displays a signal as a time waveform (time course) or a two-dimensional image has also been developed (for example, Patent Document 3).

  These biological light measurements are mainly based on the relationship between the relative changes in blood substances before and after the stimulus and the brain function (for example, giving a visual stimulus and knowing the brain activity of the visual cortex) It is generally used as a brain function measurement method. However, there are few devices that use the same technique to measure functional changes and physiological changes in organs other than the brain. When measuring salivary gland function, MRI, ultrasonic echo, and scintigraphy are used. Is difficult to monitor.

  In addition, changes in saliva secretion are also associated with changes in oral conditions (dry mouth, bad breath, ease of swallowing and chewing, speech), and mental conditions. When measuring the amount of saliva secretion, a method of chewing absorbent cotton and exhaling saliva for several minutes is taken, and it is difficult to measure in real time non-invasively.

JP 57-115232 A JP 63-275323 A Japanese Patent Laid-Open No. 9-98972

  Conventional biological light measurement devices are used as a brain function measurement method, and we have not attempted to measure functional changes or physiological changes in organs other than the brain, and it is unknown whether functional changes in organs other than the brain can be measured. there were. For clinical examination of functional changes in salivary glands, which are organs other than the brain, in general, MRI, ultrasound echo, and scintigraphy are used, but the measurement time is long, restrictive and invasive, and real-time The function change could not be monitored. Saliva has the effect of maintaining the oral environment in addition to the digestive action of food. For example, there are dirt cleaning action, speech and chewing smooth action, antibacterial action, pH maintenance action (preventing bacterial growth), and the like. Therefore, changes in the ability to secrete the salivary glands are also deeply related to bad breath, dental caries, swallowing and chewing, and speech activity. In order to measure the salivary secretion ability, it takes several minutes to several tens of minutes to spit out saliva and take out cotton by putting it in the oral cavity, but measure the salivary gland secretion ability in real time. I couldn't. Then, this invention makes it a subject to implement | achieve the biological light measuring device which can measure a salivary gland function.

  The biological optical measurement device of the present invention includes an optical measurement unit that irradiates light in the vicinity of the salivary gland from the temporal region to the lower jaw and receives reflected or transmitted light, and a measurement signal received by the optical measurement unit. And a signal processing means for rendering a blood substance concentration change accompanying a change in salivary gland function when the subject is stimulated as a signal waveform, and a display means for displaying a processing result of the signal processing means.

  When measuring functional changes in salivary glands, MRI, ultrasound echo, and scintigraphy are used. However, there are problems such as restraint and invasiveness, long measurement time, and inability to monitor functional changes in real time. was there. According to the present invention, the state of the salivary gland can be measured in real time in a non-invasive manner, with low restraint and in a short time by using the biological light measurement technique.

  First, the salivary glands will be described. FIG. 1 shows the position of the salivary glands. The salivary gland is composed of a major salivary gland and a minor salivary gland. The major salivary gland includes a parotid gland 1, a submandibular gland 2, and a sublingual gland 3. The largest parotid gland is a serous gland that is 5-6 cm long and 2-3 mm thick, located in front of the ear and at the tip of the cheekbone. The submandibular gland is a mixed gland of serous and mucous glands, about 5 cm long, located in the triangular part under the jaw. There are one sublingual gland, one on the left and one under the mucous membrane of the oral cavity, and the size is about 1-2 mm. The shape is tufted.

  The function of saliva production / secretion will be described. Saliva is generated from blood, converted into a component close to water by active transport, and secreted from the portion of the conduit that exits the tufted acinar. Therefore, in the region from the temporal region near the salivary gland to the lower jaw, when saliva generation / secretion occurs, oxygen consumption accompanying energy consumption occurs, and blood hemoglobin concentration changes.

  Next, the results of examining the relationship between salivary secretion and hemoglobin signal changes associated with changes in salivary gland function will be described. Secreted saliva was collected by cotton inserted between the back teeth and cheeks in the immediate vicinity of the parotid gland, and hemoglobin signal changes were measured in the region from the left and right head to the cheek and submandibular region. FIG. 2 shows changes in oxygenated hemoglobin signal at a typical reaction site when a taste stimulus in which a 1-molar sucrose solution is soaked in absorbent cotton is applied to the tongue for 1-2 seconds. Since saliva is secreted just by inserting cotton, after putting cotton into the oral cavity, the salivary gland reaction for 90 seconds is taken as the base-stimulated salivary secretion reaction (Fig. 2-a), and then in the next 90 seconds, Taste stimulation was presented and saliva stimulation response (Fig. 2-b) was measured. At the end, the cotton was taken out from the oral cavity, and the secretion amount was calculated from the change in the weight of the cotton. Irritation is presented for 1-2 seconds, 1) no irritation, 2) put a commercially available fast-dissolving film (grapefruit mint) on the tongue, 3) put absorbent cotton soaked with 1 molar sucrose on the tongue 4) Spraying a commercially available bad breath prevention spray (Cool Mint).

  FIG. 3 shows a correlation diagram between the peak value of the hemoglobin signal change due to the stimulus presentation and the saliva secretion amount. The amount of saliva secretion increased by the stimulation, and the peak value of the hemoglobin signal change was increased accordingly. It was shown that changes in salivary gland function can be measured by changes in hemoglobin signal. Further, the correlation coefficient r between the saliva secretion amount and the Hb signal was 0.79. From this relationship, it was found that the saliva secretion amount is in a linear relationship with the Hb signal (y (Hb signal) = 0.848 × (saliva secretion amount) +0.5442). Therefore, the saliva secretion amount can be calculated from a linear format with the Hb signal. Since the secretory volume of saliva can be measured using the biological light measuring device, real-time saliva volume measurement is possible.

  Moreover, as shown in FIG. 4, the saliva secretion amount and the hemoglobin signal change differed depending on the stimulus presentation method and the type of stimulus. It was shown that changes in salivary gland function depending on the type of stimulus presentation can be measured by changes in hemoglobin signal.

  Furthermore, as shown in FIG. 5, the reaction site of the hemoglobin signal change in response to the stimulus was remarkable in the upper cheek, the lower cheek, and the temple portion. Therefore, the salivary gland function can be measured by the biological light measuring device at each site. Moreover, since the submandibular line is in the vicinity of the lower jaw, the salivary gland function can be measured even if the lower jaw is measured.

  Furthermore, the living body optical measurement device of the present invention includes an optical measurement unit that can simultaneously measure any or all of the three salivary glands (parotid gland, submandibular gland, sublingual gland). Since the salivary gland is located from the auricle to the lower part of the jawbone and below the buttocks, this region is measured. Since salivary gland reaction due to taste stimulation was also observed in the temple portion of the temporal region above the auricle, a light measuring means may be provided in the temporal region.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
<Biometric measurement device for salivary gland measurement>
FIG. 6 is a block diagram showing the entirety of the biological light measurement device of the present invention. This biological light measurement device mainly includes an optical measurement unit 10, a signal processing unit 20, and a stimulus control device 30. The optical measuring unit applies the means of FIG. 17 as an example, but the means of FIGS. 18 and 19 may be used.

  The optical measurement unit 10 includes a light source unit 11 and a light detection unit 12. The light source unit 11 includes a light source such as a laser that generates light of a predetermined wavelength, a light modulation unit that modulates light generated by the light source into light of different frequencies corresponding to the number of measurement points, and modulated light. And the optical fiber 13 for guiding the subject from the head to the face or submandibular portion of the subject 40. The wavelength of light generated by the light source 11 is around 800 nm when the blood substance to be measured is hemoglobin (oxygenated hemoglobin and deoxygenated hemoglobin). Different wavelengths can be employed when the substances to be measured are different. In the present embodiment, a case where the blood substance is hemoglobin will be described.

  The measurement point in the biological light measurement is a point located approximately at the center between the light irradiation position and the light detection position, and the position and number are determined by the number and arrangement of the light irradiation position and the light detection position. Usually, a plurality of light irradiation positions and a plurality of light detection positions are alternately arranged at points on a matrix such as 3 × 3, 4 × 4, and the respective distances are appropriately separated (3 cm in the present invention). . In the case of a 3 × 3 matrix, the number of measurement points is 12. In the application of the present invention, the measurement point may be single or plural.

  The light detection unit 12 discriminates a light receiving element that receives light from the optical fiber 13 whose tip is located at a light detection position and the received light by modulation frequency or time division, and generates a hemoglobin change signal for each measurement point It consists of a detection circuit. It also includes a detection circuit equipped with spatially resolved spectroscopy that generates hemoglobin concentration using the intensity distribution with respect to the time when reflected light was detected by changing the distance between the two light receiving elements for one point of irradiated light. May be. In this case, the number of irradiation points can be two. An optical tomography method that constructs a tomographic image from transmitted light can also be used.

  The signal processing unit 20 is a hemoglobin signal processing unit 21 that performs time series processing (time course data creation) and imaging (signal waveform creation) of hemodynamic changes in the living body, and post-signal processing. Storage unit 22 for storing measurement data and display unit 23 for inputting subject information and displaying analysis data, and as an external device required for signal processing and analysis in hemoglobin signal processing unit 21 and display unit 23 An operation unit 24 such as a keyboard and a mouse for inputting various commands is provided. The data display unit 24 displays a GUI in conjunction with the operation unit 24 in addition to displaying the result image.

  Based on a command from the operation unit 24, the signal processing unit 20 inputs subject information, selects a measurement site, selects the number of times of measurement, selects a signal processing method, and displays a salivary gland function state of the subject. .

The stimulation control device 30 is a device that controls stimulation and instructions given to the subject 40, a storage unit 31 that stores stimulation images, sounds, sounds, language data, etc. as analog or digital data, A stimulus generating unit 32 such as a speaker or a PC screen for presenting sound / voice / language data to the subject, a control unit (not shown) for controlling the generation timing of the stimulus from the stimulus generating unit, and the like. Such a stimulus control device 30 may be provided as a part of the biological light measurement device, but can also be an independent device. In that case, information such as timing, time, and time when the stimulus is given is sent to the biological light measurement device (the signal processing unit 20 thereof). Alternatively, an instruction is sent from the biological light measurement device to the stimulus control device 30, and the specified stimulus of the image, sound, voice, and language data stored in the storage unit is generated at the specified timing and time according to the instruction. Also good.
<Measurement procedure GUI of biological light measurement device for salivary gland measurement>
Next, the operation of the biological light measurement device having such a configuration will be described. Note that the illustrated graphical user interface is merely an example, and the present invention is not limited to this form.

  FIG. 7 shows the flow of the measurement procedure. 8 to 15 show examples of a graphical user interface in the display unit 23.

  The subject or the measurer inputs subject information (FIG. 8). The subject information includes, for example, age, sex, meal time, presence / absence of stress, presence / absence of caries, and the like. This information is used to understand changes in the subject's salivary gland function. Information for understanding changes in other salivary gland functions can also be added. For example, the presence or absence of bad breath or the presence or absence of dry mouth. These pieces of information are displayed at the same time as the measurement results are displayed to promote understanding of the meaning of salivary gland function changes.

  Next, the measurement site is selected from the left and right of the temple portion, the upper cheek, the lower cheek, and the lower chin (FIG. 9). The right and left are selected because the salivary gland functions on both sides may be different, and it is generally known that the right and left salivary secretion ability differs depending on the salivary gland tumor or the like. Here, the measurement of the upper left and right cheeks and the lower cheek is selected. In addition, since salivation occurs only by stimulating the oral cavity, when measuring changes in salivary gland function for different stimuli, the base stimulus is selected and used to measure the response difference depending on the type of stimulus. be able to. For example, when examining saliva secretion for sugar water, drink water as a base stimulus for the first time, and drink sugar water for measurement from the second time.

  When measuring the pharynx, changes in muscle activity associated with swallowing may be used.

  Next, the number of measurements is selected (FIG. 10). The measurement is performed during a trial period in which the stimulus presentation time and the rest time are set as one set, and a hemoglobin change signal is obtained. Saliva production / secretion due to oral stimulation starts after a few seconds and peaks in a few minutes, so changes in blood substances in response to this stimulation are thought to occur in this order. Therefore, the resting time after the stimulus presentation is determined with approximately 90 seconds as a guide, but may be changed as necessary. The time to start-stimulation and the time to stimulation-end can be freely changed. This trial is performed once or a plurality of times, and the average processing, filtering processing, and baseline processing can be performed on the signal waveform obtained each time. Here, the number of measurements is one.

Next, the optical measurement unit 10 is attached to the subject, and after the attachment, the process proceeds to the start of measurement after confirming whether light irradiation-light detection is performed. From the start to the end of measurement, timing and instructions are given from the stimulus control device 30 (FIG. 11). In accordance with this signal, the subject arranges and waits for breathing during the rest period, and after 90 seconds, takes a sample prepared for oral stimulation (FIG. 12).
When the measurement is completed, it is selected whether to display the result as it is or to proceed to a detailed analysis process (FIG. 13). When “display the result as it is”, the display item of the measurement result is selected (FIG. 14). In the case of multipoint measurement, the waveform of the time-series change of the hemoglobin change signal can be displayed as an image. When performing a plurality of trials, an average added waveform and an average image can be drawn. Here, the waveform display is selected.

  When “detailed analysis processing” is selected, baseline correction, filter processing, and the like can be selected, and the results of these processing can be displayed (FIG. 14). Here, the baseline correction is selected, and the waveform change of the salivary gland function is displayed (FIG. 15).

It should be noted that 1. in “Selecting Display Items” shown in FIG. About a waveform, it is a graph as shown in FIG. In addition, 2. As for the image, it is a graph that expresses a small and large number of waveforms in color. 3. 3. Addition waveform, About an addition image, it is a graph which piled up the result measured many times. 5). The left / right difference index is a graph showing the left / right difference of the subject. In “Selection of processing item”, 1. Baseline correction is as described above. In addition, 2. The filter correction is a process for removing the influence of the heartbeat by removing a signal of 0.8 to 1 Hz from the obtained signal. 3. The saliva amount calculation is a process of calculating the total saliva amount by converting the obtained Hb amount into the saliva amount by the above-described linear format and integrating the amount. In addition, stimulation can use not only oral stimulation but also video, voice, smell, and the like.
<Probe for living body light measurement device for salivary gland measurement>
FIGS. 16-21 has shown the form of the Example of the optical measurement means which measures the change of the salivary gland function of the test subject 40 in the biological light measuring device of the salivary gland function of an Example.
<Probe holder for measuring salivary glands>
FIG. 16 is a block diagram showing the optical measuring means and the subject. The optical measurement unit 10 includes a light source unit 11 and a detection unit 12, and has a function of communicating with a signal processing unit (see FIG. 6-20) by wire or wirelessly (the signal processing unit is not shown). A probe holder that is attached to the lower jaw side where the submandibular gland is located and the buttocks where the sublingual gland is located from the front of the ear to the cheek where the parotid gland is located and guides the optical fiber 13 from the light source unit 10 and the detection unit 11 14 is provided. In FIG. 16, it is fixed with a hair band, but it may be a headphone type.
<Embodiment relating to light source unit and detection unit>
FIG. 17 shows an integrated optical measurement unit 52 in which the light source unit 50 and the detection unit 51 are a pair. The light source unit 50 and the detection unit 51 are thinned by being created by nanoprinting, and can be attached to the corresponding part using a seal or the like. The optical measurement unit 52 is attached to a dedicated frame 53, and the dedicated frame 53 has a function of communicating with a signal processing unit (see FIG. 6-20) by wire or wirelessly. Such a configuration having a dedicated frame for fixing the optical measurement means to the face portion and removing only the optical measurement portion facilitates hygiene management of the portion attached to the face portion.

  FIG. 18 shows a hand-held optical measurement unit 60 having the function of an optical measurement unit incorporating a light source unit and a detection unit. Such a hand-held optical measurement unit 60 is measured while being applied to the salivary gland region of the subject 40. Specifically, in FIG. 18-60, irradiation is performed on any or all of the temple, upper cheek, lower cheek. The reason why the lower part of the chin is not irradiated is that the chin connecting the lower part of the chin and other parts is hard to wear because the curve is tight. The substrate on which the light irradiation means and the light receiving means are mounted has a curved shape that follows the cheek shape of the subject. Alternatively, the optical measurement unit 60 may be equipped with a display unit 61 to display the results from the signal processing unit (see FIG. 6-20).

  Moreover, the optical measurement part 61 on hand can also be made into a telephone type. In this case, the substrate on which the light irradiating means and the light receiving means are mounted can be freely adjusted according to the curve of the facial part according to the curve of the salivary gland part from the temporal region to the lower jaw, like a folding phone. You can change the angle. The telephone-type optical measuring unit 62 may be equipped with a display unit 63 to display the result. With such a configuration, the subject himself / herself can stably hold the optical measurement unit, and the optical measurement unit can be applied to the measurement site. In addition, such a telephone-type optical measuring unit irradiates light to the lower jaw, the temple part, the upper cheek, the lower cheek, or all the parts.

  Furthermore, as another embodiment of the present invention, FIG. 19 shows a mouthpiece type optical measuring unit for irradiating light into the oral cavity. There are light source portions 70 at both ends of the mouthpiece, and the light source portion 70 can be fixed in the oral cavity by sandwiching the mouthpiece in the mouth. With this configuration, the measurement position is difficult to shift, and the reproducibility is high, so that even if exercise is performed while wearing, the effect is not shifted. Moreover, a detection part is arrange | positioned outside the oral cavity. In the embodiment of FIG. 19, the detection unit is a headphone type. Further, the positions of the irradiation unit and the detection unit may be reversed.

  Further, a light guide 80 for guiding the light source unit 82 may be used. If the light source part 82 is put in the oral cavity along this light guide 80, safety | security becomes high. As shown in FIG. 19, these detection units 71 and 81 perform measurement by hitting a part such as a cheek from outside the oral cavity. Although these detection parts 71 and 81 may be fixed like a hair band or a headphone, it is good also as a hand-held type | mold and telephone type | mold which has only a detection part by embodiment like FIG. In addition, the detection units 71 and 81 may be provided with a display unit, and the result from the signal processing unit (see FIG. 6-20) may be displayed. Further, the light source unit and the detection unit may be reversed, the detection unit may be provided in the oral cavity, and the light source unit may be provided outside the oral cavity for measurement. When the detection unit is provided in the oral cavity, the detection unit detects the irradiation light via the light guide.

  In another embodiment of the present invention, the optical measurement means or the detection unit provided outside the oral cavity is provided with a display means for displaying the processing result. As a result, the processing result can be displayed on the measured site.

  Further, in the biological light measurement device of the present invention, the blood substance corresponding to each salivary gland function change by changing the distance between at least two detection units with respect to one light source unit and utilizing spatially resolved spectroscopy Signal processing means for extracting the absolute value of the signal, and display means for displaying the processing result of the signal processing means.

  Further, the living body optical measurement device of the present invention includes a signal processing unit that forms a tomographic image of each salivary gland by using an optical tomography method, and a display unit that displays a processing result of the signal processing unit. Yes.

  Changes in salivary gland function, which has been difficult until now, can be measured non-invasively and with low restraint in a short time by the living body optical measurement device that measures the salivary gland function shown in the present embodiment. Can be observed in real time. From changes in salivary gland function, it is possible to know a decrease in salivary secretion ability and a change in oral condition, and it is effective in assisting discrimination of salivary gland tumors, dry mice, bad breath, reduced masticatory function, and ease of tooth decay. Moreover, the response difference by taste stimulation can be measured by utilization of base stimulation.

  It is well known that changes in salivary gland function also occur when recalling food and drink. Therefore, if the recall of food and drink is controlled by one's own intention, the measurement signal can be observed with this biological light measurement device. This can also be used for communication of patients such as amyotrophic lateral sclerosis without means of communication.

Diagram showing salivary gland location Diagram of measurement protocol for salivary secretion and hemoglobin signal change Correlation diagram of salivary gland secretion and hemoglobin signal change The figure which shows the difference of the saliva secretion quantity and the hemoglobin signal change with the stimulation method Diagram showing the reaction site of hemoglobin signal change due to salivary gland function change The block diagram which shows the apparatus structure of one Embodiment of this invention. The figure which shows the measurement flowchart of one Embodiment of this invention of this invention The figure which shows the example of a measurement graphical user interface display of this invention The figure which shows the example of a measurement graphical user interface display of this invention The figure which shows the example of a measurement graphical user interface display of this invention The figure which shows the example of a measurement graphical user interface display of this invention The figure which shows the example of a measurement graphical user interface display of this invention The figure which shows the example of a measurement graphical user interface display of this invention The figure which shows the example of a measurement graphical user interface display of this invention The figure which shows the example of a measurement graphical user interface display of this invention The block diagram which shows the apparatus structure of one Embodiment of this invention. The figure which shows the example of the probe holder of one Embodiment of this invention The figure which shows the example of a measurement interface of one Embodiment of this invention The figure which shows the example of a measurement interface of one Embodiment of this invention

Explanation of symbols

40 ... Subject, 10 ... Optical measurement unit, 11 ... Light source unit, 12 ... Photodetection unit, 13 ... Optical fiber, 14 ... Probe holder, 20 ... Signal processing unit, 21 ... Hemoglobin signal processing unit, 22 ... Storage unit, 23 ... Display unit, 24 ... Operation unit, 25 ... Operation display unit, 30 ... Stimulation control device, 31 ... Stimulation control storage unit, 32 ... Stimulus generation unit, 50 ... Light source unit, 51 ... Detection unit, 52 ... Light measurement unit, 53 ... Dedicated frame, 60 ... Optical measurement unit, 61 ... Display unit, 62 ... Optical measurement unit, 63 ... Display unit, 64 ... Optical measurement unit, 70 ... Light source unit, 71 ... Detection unit, 80 ... Light guide, 81 ... Detection unit, 82 ... Light source unit

Claims (8)

A light irradiating means for irradiating the subject with light to any part of the temple, upper cheek, lower cheek, lower chin, or all;
A light receiving means for receiving light emitted from the light irradiating means;
Based on a measurement signal calculated from the light received by the light receiving means, a signal processing means for calculating a change in blood substance concentration accompanying a change in salivary gland function when stimulating the subject as a signal waveform;
One set of the light irradiation means and the light receiving means are fixed, and the light irradiation means and the light receiving means are detachable dedicated frames;
A biological light measurement device comprising: display means for displaying a processing result of the signal processing means. The biological light measurement device according to claim 1,
The biological light measurement apparatus, wherein the signal processing means communicates wirelessly from the dedicated frame. A light irradiating means for irradiating the subject with light to any part of the temple, upper cheek, lower cheek, or all;
A light receiving means for receiving light emitted from the light irradiating means;
A substrate having a curved shape following the shape of the cheek of the subject on which the plurality of light irradiation means and the light receiving means are mounted;
A hand-held portion attached to the substrate;
Based on a measurement signal calculated from the light received by the light receiving means, a signal processing means for calculating a change in blood substance concentration accompanying a change in salivary gland function when stimulating the subject as a signal waveform;
A biological light measurement device comprising: display means for displaying a processing result of the signal processing means. A light irradiation means for irradiating the subject with any of the temple part, the upper cheek, the lower cheek, and the lower jaw part;
A light receiving means for receiving light emitted from the light irradiating means;
A plurality of light emitting means and a substrate on which the light receiving means is mounted;
Based on a measurement signal calculated from the light received by the light receiving means, a signal processing means for calculating a change in blood substance concentration accompanying a change in salivary gland function when stimulating the subject as a signal waveform;
Display means for displaying the processing result of the signal processing means,
The living body light measurement apparatus according to claim 1, wherein the angle of the substrate can be changed between the lower chin and other parts. Light irradiating means for irradiating the subject with light on the lower cheek;
A light receiving means for receiving light emitted from the light irradiating means;
A mouthpiece-type substrate on which the light irradiation means is mounted;
Based on a measurement signal calculated from the light received by the light receiving means, a signal processing means for calculating a change in blood substance concentration accompanying a change in salivary gland function when stimulating the subject as a signal waveform;
Display means for displaying the processing result of the signal processing means,
The living body light measuring apparatus, wherein the light receiving means is disposed outside the oral cavity of the subject. Light irradiating means for irradiating the subject with light on the lower cheek;
A light receiving means for receiving light emitted from the light irradiating means;
A mouthpiece-type substrate on which the light receiving means is mounted;
Based on a measurement signal calculated from the light received by the light receiving means, a signal processing means for calculating a change in blood substance concentration accompanying a change in salivary gland function when stimulating the subject as a signal waveform;
Display means for displaying the processing result of the signal processing means,
The biological light measurement device, wherein the light irradiation means is disposed outside the oral cavity of the subject. A light irradiating means for irradiating the subject with light to any part of the temple, upper cheek, lower cheek, lower chin, or all;
Receiving light emitted from the light irradiation means, and a light receiving means disposed outside the oral cavity of the subject;
Based on a measurement signal calculated from the light received by the light receiving means, a signal processing means for calculating a change in blood substance concentration accompanying a change in salivary gland function when stimulating the subject as a signal waveform;
Display means for displaying a processing result of the signal processing means;
A biological light measurement apparatus comprising: a light guide unit that guides light irradiated by the light irradiation unit to the parts of all subjects. The biological light measurement device according to any one of claims 1 to 7,
The biological light measuring apparatus, wherein the signal processing means further calculates a saliva secretion amount from the change in the blood substance concentration.

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