JP2009545609A5 - - Google Patents
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- Publication number
- JP2009545609A5 JP2009545609A5 JP2009522936A JP2009522936A JP2009545609A5 JP 2009545609 A5 JP2009545609 A5 JP 2009545609A5 JP 2009522936 A JP2009522936 A JP 2009522936A JP 2009522936 A JP2009522936 A JP 2009522936A JP 2009545609 A5 JP2009545609 A5 JP 2009545609A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- agonist
- chemotherapeutic agent
- tumor
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 39
- 239000002246 antineoplastic agent Substances 0.000 claims description 33
- 239000000556 agonist Substances 0.000 claims description 31
- 206010028980 Neoplasm Diseases 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 17
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 13
- 229960004679 Doxorubicin Drugs 0.000 claims description 13
- VSJKWCGYPAHWDS-FQEVSTJZSA-N Camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 10
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 10
- DXPHNGAMYPPTBJ-TZMIJSMNSA-N Irl 1620 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(C)C)C1=CN=CN1 DXPHNGAMYPPTBJ-TZMIJSMNSA-N 0.000 claims description 10
- 229960001592 Paclitaxel Drugs 0.000 claims description 10
- 229930003347 taxol Natural products 0.000 claims description 10
- 125000000998 L-alanino group Chemical group [H]N([*])[C@](C([H])([H])[H])([H])C(=O)O[H] 0.000 claims description 9
- GHASVSINZRGABV-UHFFFAOYSA-N 5-flurouricil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 8
- 229960002949 Fluorouracil Drugs 0.000 claims description 8
- 229940009456 Adriamycin Drugs 0.000 claims description 5
- 229960004562 Carboplatin Drugs 0.000 claims description 5
- OLESAACUTLOWQZ-UHFFFAOYSA-L Carboplatin Chemical compound O=C1O[Pt]([N]([H])([H])[H])([N]([H])([H])[H])OC(=O)C11CCC1 OLESAACUTLOWQZ-UHFFFAOYSA-L 0.000 claims description 5
- STQGQHZAVUOBTE-VGBVRHCVSA-N DAUNOMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims description 5
- 229960000975 Daunorubicin Drugs 0.000 claims description 5
- 102000003996 Interferon beta Human genes 0.000 claims description 5
- 108090000467 Interferon beta Proteins 0.000 claims description 5
- 102000006992 Interferon-alpha Human genes 0.000 claims description 5
- 108010047761 Interferon-alpha Proteins 0.000 claims description 5
- 102000008070 Interferon-gamma Human genes 0.000 claims description 5
- 108010074328 Interferon-gamma Proteins 0.000 claims description 5
- 102000000588 Interleukin-2 Human genes 0.000 claims description 5
- 108010002350 Interleukin-2 Proteins 0.000 claims description 5
- UWKQSNNFCGGAFS-XIFFEERXSA-N Irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 5
- 101700082307 SRTX Proteins 0.000 claims description 5
- UCFGDBYHRUNTLO-QHCPKHFHSA-N Topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims description 5
- 230000036770 blood supply Effects 0.000 claims description 5
- 229960004316 cisplatin Drugs 0.000 claims description 5
- 229940044627 gamma-interferon Drugs 0.000 claims description 5
- 229960004768 irinotecan Drugs 0.000 claims description 5
- 229960000303 topotecan Drugs 0.000 claims description 5
- LXZZYRPGZAFOLE-UHFFFAOYSA-L transplatin Chemical compound [H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H] LXZZYRPGZAFOLE-UHFFFAOYSA-L 0.000 claims description 5
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N Docetaxel Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 4
- 108050009340 Endothelin Proteins 0.000 claims description 4
- 102000002045 Endothelin Human genes 0.000 claims description 4
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N Endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 229960003668 docetaxel Drugs 0.000 claims description 4
- 210000000481 Breast Anatomy 0.000 claims description 2
- 208000000409 Breast Neoplasms Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 210000001072 Colon Anatomy 0.000 claims description 2
- 206010019695 Hepatic neoplasm Diseases 0.000 claims description 2
- 208000007766 Kaposi Sarcoma Diseases 0.000 claims description 2
- 206010025650 Malignant melanoma Diseases 0.000 claims description 2
- 206010027191 Meningioma Diseases 0.000 claims description 2
- 208000002163 Phyllodes Tumor Diseases 0.000 claims description 2
- 206010071776 Phyllodes tumour Diseases 0.000 claims description 2
- 210000002307 Prostate Anatomy 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 230000002611 ovarian Effects 0.000 claims description 2
- KIYSPBOGUDIMPC-SCGUGKIPSA-N 4-Ala-endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)OC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)[C@@H](C)CC)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)OC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](C)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCSC)C(C)C)C1C=NC=N1 KIYSPBOGUDIMPC-SCGUGKIPSA-N 0.000 description 1
- -1 docetacel Chemical compound 0.000 description 1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/461,961 US20070032422A1 (en) | 2002-10-24 | 2006-08-02 | Methods, compositions and articles of manufacture for contributing to the treatment of cancers |
PCT/US2007/074036 WO2008016793A2 (en) | 2006-08-02 | 2007-07-20 | Methods, compositions and articles of manufacture for contributing to the treatment of cancers |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009545609A JP2009545609A (ja) | 2009-12-24 |
JP2009545609A5 true JP2009545609A5 (zh) | 2011-07-28 |
Family
ID=38752363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009522936A Pending JP2009545609A (ja) | 2006-08-02 | 2007-07-20 | 癌の治療に寄与する方法、組成物および製造物品 |
Country Status (18)
Country | Link |
---|---|
US (4) | US20070032422A1 (zh) |
EP (2) | EP2450037A1 (zh) |
JP (1) | JP2009545609A (zh) |
KR (1) | KR101507178B1 (zh) |
CN (1) | CN101522186B (zh) |
AR (1) | AR062177A1 (zh) |
BR (1) | BRPI0715521A2 (zh) |
CA (1) | CA2658340C (zh) |
DK (1) | DK2046323T3 (zh) |
ES (1) | ES2402232T3 (zh) |
HK (1) | HK1129601A1 (zh) |
IL (1) | IL196825A (zh) |
MX (1) | MX2009001233A (zh) |
NO (1) | NO20090915L (zh) |
RU (1) | RU2407527C2 (zh) |
TW (1) | TWI469776B (zh) |
WO (1) | WO2008016793A2 (zh) |
ZA (1) | ZA200900017B (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070032422A1 (en) | 2002-10-24 | 2007-02-08 | Spectrum Pharmaceuticals, Inc. | Methods, compositions and articles of manufacture for contributing to the treatment of cancers |
US8026216B2 (en) | 2002-10-24 | 2011-09-27 | Spectrum Pharmaceuticals, Inc. | Methods and compositions for contributing to the treatment of cancers |
EP2059254B1 (en) | 2006-08-31 | 2015-04-08 | Spectrum Pharmaceuticals, Inc. | Sensitization of tumor cells to radiation therapy through the administration of endothelin agonists |
WO2009026282A2 (en) * | 2007-08-21 | 2009-02-26 | Midwestern University | Compositions for the treatment of stroke or cerebrovascular accidents with an endothelin b receptor agonist |
US9308235B2 (en) * | 2012-05-09 | 2016-04-12 | Spectrum Pharmaceuticals, Inc. | Treatment of primary and metastatic carcinoma |
CN109069472B (zh) * | 2016-05-06 | 2022-01-04 | 一般财团法人生物动力学研究所 | 含有高分子化药物的医药组合物 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5550110A (en) | 1992-04-22 | 1996-08-27 | Warner-Lambert Company | Endothelin Antagonists II |
CA2135151A1 (en) | 1993-11-08 | 1995-05-09 | Mitsuhiro Wakimasu | Cyclic hexapeptides, their production and use |
US5811416A (en) | 1994-06-06 | 1998-09-22 | Board Of Regents The University Of Texas System | Endothelin antagonist and/or endothelin synthase inhibitor in combination with a progestin, an estrogen, a cyclooxygenase inhibitor, or a nitric acid donor or substrate |
US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
CN1160115C (zh) | 1994-12-12 | 2004-08-04 | 奥默罗斯公司 | 用于抑制疼痛,炎症和痉挛的冲洗液和方法 |
US6251861B1 (en) | 1996-06-27 | 2001-06-26 | Takeda Chemical Industries, Ltd. | Treatment of cerebral infarction using cyclic hexapeptides |
EP0950418A2 (en) | 1998-04-14 | 1999-10-20 | Takeda Chemical Industries, Ltd. | Composition for preventing or treating ischemic disease |
YU22401A (sh) | 1998-09-25 | 2004-03-12 | Warner-Lambert Company | Kombinacija acetildinalina sa gemcitabinom, capecitabinom i cisplatinom |
US7566452B1 (en) | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
US6545048B1 (en) | 1999-06-29 | 2003-04-08 | California Institute Of Technology | Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity |
US6635677B2 (en) | 1999-08-13 | 2003-10-21 | Case Western Reserve University | Methoxyamine combinations in the treatment of cancer |
MXPA02010764A (es) | 2000-05-31 | 2003-03-10 | Warner Lambert Co | Combinaciones de un antagonista del receptor endotelina y un compuesto antiepileptico que tiene propiedades para aliviar el dolor o analgesico. |
WO2002049630A2 (en) | 2000-12-21 | 2002-06-27 | Bristol-Myers Squibb Company | Method for preventing or treating pain by administering an endothelin antagonist |
AU2002355266A1 (en) | 2001-07-23 | 2003-02-17 | Brigham And Women's Hospital, Inc. | Analgesic methods using endothelin receptor ligands |
US7973064B2 (en) | 2001-11-27 | 2011-07-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for potentiating an opiate analgesic |
US20030229004A1 (en) | 2002-03-20 | 2003-12-11 | Pangene Corporation | Modulation of tumor cells using BER inhibitors in combination with a sensitizing agent and DSBR inhibitors |
US8026216B2 (en) | 2002-10-24 | 2011-09-27 | Spectrum Pharmaceuticals, Inc. | Methods and compositions for contributing to the treatment of cancers |
US20070032422A1 (en) | 2002-10-24 | 2007-02-08 | Spectrum Pharmaceuticals, Inc. | Methods, compositions and articles of manufacture for contributing to the treatment of cancers |
US8217010B2 (en) | 2002-10-24 | 2012-07-10 | The Board Of Trustees Of The University Of Illinois | Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors |
CN1729012B (zh) * | 2002-10-24 | 2013-05-22 | 伊利诺伊大学评议会 | 治疗实体瘤的组合物 |
WO2006057988A2 (en) | 2004-11-22 | 2006-06-01 | The Board Of Trustees Of The University Of Illinois | Use of endothelin etb receptor agonists and eta receptor antagonists in tumor imaging |
WO2006091767A2 (en) * | 2005-02-22 | 2006-08-31 | Spectrum Pharmaceuticals, Inc. | Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors |
EP2059254B1 (en) | 2006-08-31 | 2015-04-08 | Spectrum Pharmaceuticals, Inc. | Sensitization of tumor cells to radiation therapy through the administration of endothelin agonists |
-
2006
- 2006-08-02 US US11/461,961 patent/US20070032422A1/en not_active Abandoned
-
2007
- 2007-07-20 ES ES07799742T patent/ES2402232T3/es active Active
- 2007-07-20 CN CN2007800288089A patent/CN101522186B/zh not_active Expired - Fee Related
- 2007-07-20 MX MX2009001233A patent/MX2009001233A/es active IP Right Grant
- 2007-07-20 EP EP12153542A patent/EP2450037A1/en not_active Withdrawn
- 2007-07-20 KR KR1020097001590A patent/KR101507178B1/ko active IP Right Grant
- 2007-07-20 WO PCT/US2007/074036 patent/WO2008016793A2/en active Application Filing
- 2007-07-20 EP EP07799742A patent/EP2046323B1/en active Active
- 2007-07-20 DK DK07799742.7T patent/DK2046323T3/da active
- 2007-07-20 CA CA2658340A patent/CA2658340C/en active Active
- 2007-07-20 JP JP2009522936A patent/JP2009545609A/ja active Pending
- 2007-07-20 BR BRPI0715521-2A patent/BRPI0715521A2/pt not_active IP Right Cessation
- 2007-07-20 RU RU2009107085/14A patent/RU2407527C2/ru not_active IP Right Cessation
- 2007-08-01 TW TW96128166A patent/TWI469776B/zh active
- 2007-08-01 AR ARP070103398A patent/AR062177A1/es not_active Application Discontinuation
-
2009
- 2009-01-05 ZA ZA200900017A patent/ZA200900017B/xx unknown
- 2009-02-01 IL IL196825A patent/IL196825A/en not_active IP Right Cessation
- 2009-02-20 US US12/390,376 patent/US8030278B2/en not_active Expired - Lifetime
- 2009-02-27 NO NO20090915A patent/NO20090915L/no not_active Application Discontinuation
- 2009-10-09 HK HK09109362.2A patent/HK1129601A1/xx unknown
-
2011
- 2011-08-29 US US13/220,358 patent/US8440620B2/en not_active Expired - Lifetime
-
2012
- 2012-12-11 US US13/711,519 patent/US8729023B2/en not_active Expired - Lifetime
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