JP2009529356A - 組織接着剤およびシーラント、ならびにそれらの使用方法 - Google Patents
組織接着剤およびシーラント、ならびにそれらの使用方法 Download PDFInfo
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- JP2009529356A JP2009529356A JP2008557362A JP2008557362A JP2009529356A JP 2009529356 A JP2009529356 A JP 2009529356A JP 2008557362 A JP2008557362 A JP 2008557362A JP 2008557362 A JP2008557362 A JP 2008557362A JP 2009529356 A JP2009529356 A JP 2009529356A
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- avidin
- biotin
- biocompatible
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- 150000003904 phospholipids Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
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- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
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- 239000012268 protein inhibitor Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
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- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
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- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 description 1
- LMEWRZSPCQHBOB-UHFFFAOYSA-M silver;2-hydroxypropanoate Chemical compound [Ag+].CC(O)C([O-])=O LMEWRZSPCQHBOB-UHFFFAOYSA-M 0.000 description 1
- CLDWGXZGFUNWKB-UHFFFAOYSA-M silver;benzoate Chemical compound [Ag+].[O-]C(=O)C1=CC=CC=C1 CLDWGXZGFUNWKB-UHFFFAOYSA-M 0.000 description 1
- MNMYRUHURLPFQW-UHFFFAOYSA-M silver;dodecanoate Chemical compound [Ag+].CCCCCCCCCCCC([O-])=O MNMYRUHURLPFQW-UHFFFAOYSA-M 0.000 description 1
- LTYHQUJGIQUHMS-UHFFFAOYSA-M silver;hexadecanoate Chemical compound [Ag+].CCCCCCCCCCCCCCCC([O-])=O LTYHQUJGIQUHMS-UHFFFAOYSA-M 0.000 description 1
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- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
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- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
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- 229960003500 triclosan Drugs 0.000 description 1
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J189/00—Adhesives based on proteins; Adhesives based on derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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|---|---|---|---|
| US77729706P | 2006-02-28 | 2006-02-28 | |
| PCT/US2007/005235 WO2007100882A2 (en) | 2006-02-28 | 2007-02-28 | Tissue adhesives and sealants and methods for their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009529356A true JP2009529356A (ja) | 2009-08-20 |
| JP2009529356A5 JP2009529356A5 (https=) | 2011-03-10 |
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| JP2008557362A Pending JP2009529356A (ja) | 2006-02-28 | 2007-02-28 | 組織接着剤およびシーラント、ならびにそれらの使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7858079B2 (https=) |
| EP (2) | EP3050578B1 (https=) |
| JP (1) | JP2009529356A (https=) |
| AU (1) | AU2007221051B2 (https=) |
| CA (1) | CA2638038A1 (https=) |
| WO (1) | WO2007100882A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012064126A3 (ko) * | 2010-11-10 | 2012-07-19 | 주식회사 바이오리더스 | 의료용 접착제 조성물 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835513B2 (en) * | 2006-02-28 | 2014-09-16 | Covidien Lp | Drug delivery devices |
| US8349349B2 (en) * | 2006-02-28 | 2013-01-08 | Covidien Lp | Tissue adhesives and sealants and method for their use |
| EP3050578B1 (en) * | 2006-02-28 | 2020-08-05 | Covidien LP | Tissue adhesive and sealants and methods for their use |
| US20110243913A1 (en) * | 2010-04-06 | 2011-10-06 | Orthovita, Inc. | Biomaterial Compositions and Methods of Use |
| US10182973B2 (en) | 2010-11-10 | 2019-01-22 | Stryker European Holdings I, Llc | Polymeric bone foam composition and method |
| KR101297815B1 (ko) | 2010-11-18 | 2013-09-03 | 충남대학교산학협력단 | 폴리감마글루탐산과 광학영상다이의 복합체를 함유하는 센티넬 림프노드 감지용 광학영상 프로브 |
| KR101398214B1 (ko) | 2011-04-06 | 2014-05-23 | 주식회사 바이오리더스 | 음이온성 고분자와 양이온성 고분자 이온복합체 기반 고감도 자기공명영상 나노조영제 및 이의 제조방법 |
| CA2793349A1 (en) * | 2011-11-18 | 2013-05-18 | Covidien Lp | Novel drug delivery devices |
| US9161756B2 (en) | 2012-03-16 | 2015-10-20 | Covidien Lp | Closure tape dispenser |
| US9572580B2 (en) | 2012-03-16 | 2017-02-21 | Covidien Lp | Closure tape dispenser |
| US11357542B2 (en) | 2019-06-21 | 2022-06-14 | Covidien Lp | Valve assembly and retainer for surgical access assembly |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000502883A (ja) * | 1995-11-09 | 2000-03-14 | ブリストル−マイヤーズ スクイブ カンパニー | 安定なアビジン組成物及びその使用方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3009032C2 (de) | 1980-03-08 | 1983-11-24 | B.A.T. Cigaretten-Fabriken Gmbh, 2000 Hamburg | Verfahren zur Herstellung von Aromastoffen für Rauchprodukte |
| AT366916B (de) | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| US4361055A (en) | 1980-05-19 | 1982-11-30 | Juris Murnieks | Torque converter |
| US4978336A (en) | 1987-09-29 | 1990-12-18 | Hemaedics, Inc. | Biological syringe system |
| US4874368A (en) | 1988-07-25 | 1989-10-17 | Micromedics, Inc. | Fibrin glue delivery system |
| US4979942A (en) * | 1989-10-16 | 1990-12-25 | Johnson & Johnson Medical, Inc. | Two component syringe delivery system |
| US5368563A (en) * | 1991-12-18 | 1994-11-29 | Micromedics, Inc. | Sprayer assembly for physiologic glue |
| US5482698A (en) * | 1993-04-22 | 1996-01-09 | Immunomedics, Inc. | Detection and therapy of lesions with biotin/avidin polymer conjugates |
| US6306454B1 (en) | 1994-10-17 | 2001-10-23 | Baxter International Inc. | Method for producing improved medical devices and devices so produced |
| US6638508B2 (en) | 1995-12-21 | 2003-10-28 | Yeda Research And Development Co., Ltd. | Modified avidin-type molecules as targeting agents for the liver and cells of the reticuloendothelial system |
| US6121027A (en) * | 1997-08-15 | 2000-09-19 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
| US6884842B2 (en) * | 1997-10-14 | 2005-04-26 | Alnis Biosciences, Inc. | Molecular compounds having complementary surfaces to targets |
| AU745893B2 (en) * | 1997-12-19 | 2002-04-11 | United States Surgical Corporation | Two component dispenser system |
| US6632922B1 (en) * | 1998-03-19 | 2003-10-14 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
| US6333051B1 (en) * | 1998-09-03 | 2001-12-25 | Supratek Pharma, Inc. | Nanogel networks and biological agent compositions thereof |
| AU1174900A (en) | 1998-11-10 | 2000-05-29 | Yeda Research And Development Co. Ltd. | Avidin derivatives and uses thereof |
| ATE419528T1 (de) * | 1999-04-28 | 2009-01-15 | Eidgenoess Tech Hochschule | Polyionische beschichtungen für analytische und sensor-vorrichtungen |
| AU6372900A (en) | 1999-07-22 | 2001-02-13 | Pericor Science, Inc. | Linkage of agents to tissue |
| AU2001270231A1 (en) * | 2000-06-28 | 2002-01-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Localized delivery to a target surface |
| US6544543B1 (en) * | 2000-12-27 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Periodic constriction of vessels to treat ischemic tissue |
| GB0115320D0 (en) | 2001-06-22 | 2001-08-15 | Univ Nottingham | Matrix |
| US6844028B2 (en) * | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
| WO2003046144A2 (en) * | 2001-11-26 | 2003-06-05 | Molecular Reflections, Inc. | Microscale immobilization of molecules using a hydrogel and methods of use thereof |
| US7550444B2 (en) * | 2004-03-26 | 2009-06-23 | Surmodics, Inc. | Composition and method for preparing biocompatible surfaces |
| US7553810B2 (en) * | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
| EP1856179B1 (en) | 2004-12-10 | 2013-05-15 | Kala Pharmaceuticals, Inc. | Functionalized poly (ether-anhydride) block copolymers |
| US8349349B2 (en) | 2006-02-28 | 2013-01-08 | Covidien Lp | Tissue adhesives and sealants and method for their use |
| EP3050578B1 (en) | 2006-02-28 | 2020-08-05 | Covidien LP | Tissue adhesive and sealants and methods for their use |
| US8293486B2 (en) | 2009-07-21 | 2012-10-23 | Trustees Of Tufts College | Functionalization of silk material by avidin-biotin interaction |
-
2007
- 2007-02-28 EP EP16159311.6A patent/EP3050578B1/en not_active Ceased
- 2007-02-28 WO PCT/US2007/005235 patent/WO2007100882A2/en not_active Ceased
- 2007-02-28 EP EP07751965.0A patent/EP1993588B1/en not_active Not-in-force
- 2007-02-28 US US11/712,333 patent/US7858079B2/en not_active Expired - Fee Related
- 2007-02-28 AU AU2007221051A patent/AU2007221051B2/en not_active Ceased
- 2007-02-28 CA CA002638038A patent/CA2638038A1/en not_active Abandoned
- 2007-02-28 JP JP2008557362A patent/JP2009529356A/ja active Pending
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2010
- 2010-11-23 US US12/952,520 patent/US8753619B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000502883A (ja) * | 1995-11-09 | 2000-03-14 | ブリストル−マイヤーズ スクイブ カンパニー | 安定なアビジン組成物及びその使用方法 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6012037269; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ４２, 2001, １５６３-１５６５ * |
| JPN6012037270; Ｌａｎｇｍｕｉｒ １８, 2002, ２２０-２３０ * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012064126A3 (ko) * | 2010-11-10 | 2012-07-19 | 주식회사 바이오리더스 | 의료용 접착제 조성물 |
| KR101200960B1 (ko) | 2010-11-10 | 2012-12-18 | 주식회사 바이오리더스 | 의료용 접착제 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3050578B1 (en) | 2020-08-05 |
| EP3050578A1 (en) | 2016-08-03 |
| US8753619B2 (en) | 2014-06-17 |
| WO2007100882A2 (en) | 2007-09-07 |
| AU2007221051A1 (en) | 2007-09-07 |
| EP1993588A4 (en) | 2012-09-26 |
| EP1993588A2 (en) | 2008-11-26 |
| WO2007100882A3 (en) | 2009-04-16 |
| US20110062046A1 (en) | 2011-03-17 |
| AU2007221051B2 (en) | 2012-11-08 |
| EP1993588B1 (en) | 2016-04-13 |
| US20070202075A1 (en) | 2007-08-30 |
| US7858079B2 (en) | 2010-12-28 |
| CA2638038A1 (en) | 2007-09-07 |
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