JP2009527311A5 - - Google Patents

Claims (22)

A composition comprising an injectable gel of injectable bioabsorbable polysaccharides selected from chitosan and chitosan derivatives and absorbable chitin and / or chitosan particles in suspension in said gel. The polysaccharide is, 3 0 to 95%, preferably 7 0 to 90%, more preferably 7 Five et 8 5%, even more preferably 8 0 to 8 5% and most preferably The composition according to claim 1, wherein is selected from chitosan and derivatives thereof having a degree of deacetylation of about 85%.   The composition of claim 1 or 2, wherein the injectable bioabsorbable polysaccharide is succinochitosan glutamate. 0.1 or et 2 0% w / w, preferably 1 to 10% w / w, chitosan or its derivatives and more preferably from 1 5% w / w, as an injectable bioresorbable polysaccharide The composition according to any one of claims 1 to 3, comprising.   The composition according to any one of claims 1 to 4, wherein the polysaccharide is a chitosan or chitosan derivative derived from a plant.   The composition according to any one of claims 1 to 5, wherein the polysaccharide is chitosan or a chitosan derivative derived from an animal. The chitosan down also properly before Symbol injectable bioresorbable polysaccharide and / or the particles derived from chitosan chitin GMP-grade, composition according to any one of claims 1 to 6. The amount of absorbent particles in said composition, during the total weight sac Chi 0.1 or al 1 0% of the composition, preferably between 1, 4, and 5%, more preferably 1 or et 2 8. A composition according to any one of claims 1 to 7 having a weight between%.   9. A composition according to any one of claims 1 to 8, wherein the absorbent particles consist essentially of chitin.   The composition according to any one of claims 1 to 9, wherein the absorbent particles are microspheres. It said absorbent particles 3 or al 1 50 [mu] m, preferably have an average diameter of from 5 40 [mu] m, the composition according to any one of claims 1 10.   12. A composition according to any one of the preceding claims, wherein the composition is essentially free of any additional formulation modifiers.   13. A composition according to any one of claims 1 to 12, wherein the absorbent particles have a bioabsorption time of 1 to 6 months.   14. The composition according to any one of claims 1 to 13, wherein the concentration of the composition is equivalent to the concentration of the particles. Chitosan having a degree of deacetylation of 70 to 90% is dissolved, followed by continuous addition and neutralization of glutamic acid and succinic anhydride, chitin and / or performed before or after the addition of glutamic acid and / or in the final step 15. A method for producing a composition according to any one of claims 1 to 14, comprising the stirring addition of particles comprising chitosan and an optional sterilization step.   A medical device comprising the composition according to any one of claims 1 to 14.   The medical device of claim 16, wherein the composition is ready for use in a sterile syringe.   15. A method of aesthetic treatment wherein the composition according to any one of claims 1 to 14 is injected via a subcutaneous or intradermal route to fill any facial or body cavity of a human or animal. .   19. A method according to claim 18, wherein the cavity to be filled is a cavity in the skin area resulting from wrinkles, fine lines, skin depression, acne scars or other wounds.   20. A method according to claim 18 or 19, wherein multiple consecutive injections are made.   21. A method according to any one of claims 18 to 20, wherein the cavity is the result of lipoatrophy.   21. A method according to any one of claims 18 to 20, wherein the treatment is to fill a gingival depression.