JP2009519235A - Dentifrice composition comprising a binder system comprising a hydrophilic clay material - Google Patents

Abstract

  A dentifrice composition having a viscosity of from about 10,000 Pa to about 450,000 Pa comprises: (a) a binder system comprising natural rubbers derived from a hydrophilic clay material, a modified cellulose polymer, a carboxyvinyl polymer and an anionic polymer; b) comprising an effective amount of an oral care active and (c) a polar solvent carrier.

Description

  The present invention relates to a dentifrice composition comprising a binder system comprising a hydrophilic clay material and provides high stability for a wide range of formulations.

  Dentifrice compositions such as toothpastes are routinely used by consumers as part of an oral care hygiene regimen. It is well known that oral care products can provide consumers with both therapeutic and cosmetic health benefits. Therapeutic benefits include, but are not limited to, caries prevention, gingivitis prevention and hypersensitivity modulation. Cosmetic benefits include adjustment of plaque and tartar prescriptions, removal and prevention of tooth stains, tooth whitening, respiratory freshening and mouthfeel aesthetics such as fresh or slippery sensations. It is not limited to these.

  The use of abrasives such as silica has long been considered important to provide the above therapeutic and cosmetic benefits of dentifrice compositions. Abrasives add physical wear between the toothbrush and teeth to clean plaque, stains and tartar, while at the same time building the rheology and structure of the dentifrice to maintain the thermal stability of the overall formulation.

  At the same time, however, the use of high levels of abrasives can have a negative impact on the overall formulation. For example, the cost of silica itself is expensive. Furthermore, silica adsorbs the components of typical dentifrice compositions such as active agent agents, flavors and foaming agents, so the concentration of these components is adjusted to allow for loss due to silica. There must be. Furthermore, certain active agent agents such as cetylpyridinium chloride are poorly compatible with silica and therefore cannot be included in dentifrice compositions despite their well-known effects. In another aspect, the general consumer concept is that if the teeth are brushed too hard, the abrasive may attack the enamel.

  Based on the above, there is a need for a dentifrice composition that can still provide the benefits of conventional dentifrice compositions with little or no abrasive. Specifically, there is a need for a dentifrice composition that is thermally stable over a wide range of formulations and can provide the same cleaning benefits to the market.

The present invention
(A)
i) hydrophilic clay material,
ii) modified cellulose polymer,
a binder system having a viscosity of from about 10,000 Pa to about 450,000 Pa comprising iii) carboxyvinyl polymer and iv) natural rubbers derived from anionic polymers;
(B) an effective amount of an oral care active substance;
(C) A dentifrice composition comprising a polar solvent carrier.

  The present invention is further directed to a method of cleaning teeth without an abrasive.

  These and other features, aspects and advantages of the present invention will become apparent to those skilled in the art upon reading the disclosure herein together with the appended claims.

  The following list is a definition of terms used herein.

  “Including” means that other steps and other components that do not affect the final result can be added. This term encompasses the terms “consisting of” and “consisting essentially of”.

  Unless otherwise stated, all percentages are by weight of the entire composition.

  All cited references are incorporated herein by reference in their entirety. Citation of any reference is not an admission regarding a limitation on the usefulness of the claimed invention as prior art.

  Unless otherwise stated, all ratios are weight ratios.

  The present invention is described in detail as follows with respect to its product and process aspects.

a) Binder System The composition of the present invention comprises a binder system that swells or thickens in the presence of a polar solvent and provides a safe and aesthetically pleasing base for oral care use. The binder system includes natural rubbers derived from hydrophilic clay materials, modified cellulose polymers, carboxyvinyl polymers and anionic polymers, each of which is described in detail below. The combination of the four specific binder materials provides a suitable rheology for the dentifrice composition at a relatively low amount of each binder, and thus at a low cost, while also including various oral care actives. Surprisingly, the present binder system provides a dentifrice composition that uses an abrasive at a low level, such as less than about 10% by weight of the composition, and is stable even when substantially no abrasive is used. Found to provide. The binder system, in the typical toothpaste form, is from about 10,000 Pa to about 450,000 Pa, preferably from about 10,000 Pa to about 250,000 Pa, as measured with a B-type viscometer with a TE spindle. Provides a suitable viscosity.

  The amount of each of the four binders is selected based on the desired rheology and aesthetic characteristics. The total binder system is preferably from about 0.1% to about 10% of the total composition, more preferably from about 0.1% to about 5%, and even more preferably from about 0.1% to about 3%. .

ai) Hydrophilic clay material The composition of the present invention comprises a hydrophilic clay material. The hydrophilic clay material preferably comprises from about 0.01% to about 5%, more preferably from about 0.01% to about 4% by weight of the total composition.

  Hydrophilic clay materials useful herein include natural and synthetic layered silicate minerals, fumed silicas, thickened precipitated silicas and mixtures thereof. Layered silicate minerals may be naturally occurring or synthesized and have magnesium substituted with specific parts of the mineral. Fumed silicas are those that have a particle size of less than about 5 μm, typically about 1 nanometer to about 1 μm, with very little or no polishing function. The thickened precipitated silica is one having a DOA value of at least about 150 mL / 100 g, preferably at least about 250 mL / 100 g, and a particle size of about 1 μm to about 50 μm. Thickened precipitated silica can be distinguished from abrasive silica materials by its high oil absorption as defined by the DOA value. Such characteristics provide thickening.

  Commercially available hydrophilic clay materials useful herein include synthetic layered silicates under the trade name LAPONITE series available from Rockwood Additives Limited and Southern Clay Company. Magnesium, fumed silica having an average particle size of about 12 nanometers according to the aerosol series AEROSOL and CAB-O-SIL available from Cabot & Degussa Corporation J. et al. M.M. Amorphous precipitated silica with the trade name ZEODENT 165 from Huber Company and SYLOX 15 from Grace Davision and the trade name TIXOSIL from Rhodia Precipitated silica is mentioned.

a-ii) Modified Cellulose Polymer The composition of the present invention comprises a modified cellulose polymer. The modified cellulose polymer is preferably comprised of about 0.01% to about 5%, more preferably about 0.01% to about 4.5% by weight of the total composition.

  The modified cellulose polymers herein are useful binder materials for building a continuous structure in the composition. Modified cellulose polymers useful herein include sodium carboxymethylcellulose, polyvinylpyrrolidone, hydroxyethylpropylcellulose, hydroxybutylmethylcellulose, hydroxypropylmethylcellulose and hydroxyethylcellulose. Particularly useful commercially available materials include sodium carboxymethylcellulose from the brand names BLANOSE, OPTICEL 100 and AQUALON series from Hercules; the brand name Kurcel from Hercules (Hercules) KLUCEL) series hydroxyethylpropylcellulose, YIXING CITY No. Hydroxylmethylcellulose according to the trade name TF-E25 from 8 chemical plants and the trade name BENECEL series from Hercules.

a-iii) Carboxyvinyl Polymer The composition of the present invention comprises a carboxyvinyl polymer. The carboxyvinyl polymer preferably comprises about 0.01% to about 5%, more preferably about 0.01% to about 3% by weight of the total composition.

  As used herein, carboxyvinyl polymer is a useful binder material for making a three-dimensional structure in combination with the hydrophilic clay material disclosed above. Carboxyvinyl polymers useful herein include: Carbopol 956, 934, 940, 941, 1342, ETD2020, ULTRAZ 10 ", etc. Carbopol from Noveon Inc. (CARBOPOL) series (or CARBOMER) by CARBOPOL 934, 940, 974P from BF Goodrich and SYNTHALEN K available from 3V Company Things.

a-iv) Natural rubber-derived anionic polymers The composition of the present invention comprises natural rubber-derived anionic polymers. Natural rubber derived anionic polymers are preferably comprised of from about 0.01% to about 5%, more preferably from about 0.01% to about 3% by weight of the total composition.

  As used herein, anionic polymers derived from natural gum are binder materials useful for effectively adding viscosity. Natural rubbers derived from anionic polymers useful herein include carrageenan, xanthan gum, gellan gum, and locust bean gum. Particularly useful commercially available materials include the brand name KELDENT series available from CP Kelco and the xanthan gum from Rhodia under the trade name Rhodicare; the trade name from CP Kelco Gellan gum according to the KELCOGEL series; and locust bean gum under the trade name GELLOID LB from FMC BioPolymer.

a-v) Other Binders Also used herein, starch and carrageenan are useful as binder materials. Carrageenans are trade names from FMC Biopolymer (BioPolymer) and VISCARI series and GELCARIN series, trade names from Meyhall AG, MEYPRO-SOL series and CP Kelco. Under the trade names GENUVISCO series, GENU series and GENUTINE series.

b) Oral Care Active Substance The composition of the present invention comprises an oral care active substance that provides the intended therapeutic oral care benefit. Oral care actives useful herein include anticalculus agents, tin ion sources, fluoride ion sources, whitening agents, antibacterial agents, anti-plaque agents, anti-inflammatory agents, nutrients, Antioxidants, antiviral drugs, analgesics and anesthetics, zinc-containing layered materials and mixtures thereof.

b-1) Anticalculus Agents Oral care agents useful herein include anticalculus agents, which in one embodiment are from about 0.05% to about 50% by weight of the oral care composition. In another embodiment, from about 0.05% to about 25% by weight. Anticalculus agents include polyphosphates (including pyrophosphates) and salts thereof; polyaminopropane sulfonic acid (AMPS) and salts thereof; polyolefin sulfonates and salts thereof; polyvinyl phosphates and salts thereof; polyolefin phosphates Diphosphonates and salts thereof; phosphonoalkanecarboxylic acids and salts thereof; polyphosphonates and salts thereof; polyvinyl phosphonates and salts thereof; polyolefin phosphonates and salts thereof; polypeptides; As well as selected from the group consisting of these mixtures. In one embodiment, the salts are alkali metal salts. Polyphosphates are generally used as fully or partially neutralized water soluble alkali metal salts, such as potassium, sodium, ammonium and mixtures thereof. Inorganic polyphosphate salts include alkali metal (eg, sodium) tripolyphosphate, tetrapolyphosphate, dialkyl metal diacid (eg, disodium), trialkyl metal monoacid (eg, trisodium), potassium hydrogen phosphate, phosphorus Examples include sodium oxyhydrogen and alkali metal (eg, sodium) hexametaphosphate, and mixtures thereof. Polyphosphates larger than tetrapolyphosphate usually occur as amorphous glassy materials. In one embodiment, the polyphosphates are those manufactured by FMC Corporation, Sodaphos (n≈6), Hexaphos (n≈13) and Glass H (n≈ 21, sodium hexametaphosphate) and mixtures thereof. Pyrophosphate salts useful in the present invention include alkali metal pyrophosphates, di-, tri- and mono-potassium or sodium pyrophosphates, dialkali metal pyrophosphate salts, tetraalkali metal pyrophosphate salts, and mixtures thereof. It is done. In one embodiment, the pyrophosphate salt is trisodium pyrophosphate, disodium dihydrogen pyrophosphate (Na ₂ H ₂ P ₂ O ₇ ), dipotassium pyrophosphate, tetrasodium pyrophosphate (Na ₄ P ₂ O ₇ ), Selected from the group consisting of tetrapotassium pyrophosphate (K ₄ P ₂ O ₇ ), and mixtures thereof. Polyolefin sulfonates include those in which the olefin group contains 2 or more carbon atoms and salts thereof. Polyolefin phosphonates include those where the olefin group contains 2 or more carbon atoms. Polyvinyl phosphonates include polyvinyl phosphonic acid. Diphosphonates and their salts include azocycloalkane-2,2-diphosphonic acids and their salts, ions of azocycloalkane-2,2-diphosphonic acids and their salts, azacyclohexane-2,2- Diphosphonic acid, azacyclopentane-2,2-diphosphonic acid, N-methyl-azacyclopentane-2,3-diphosphonic acid, EHDP (ethane-1-hydroxy-1,1-diphosphonic acid), AHP (azacycloheptane) -2,2-diphosphonic acid), ethane-1-amino-1,1-diphosphonate, dichloromethane-diphosphonate and the like. Examples of the phosphonoalkanecarboxylic acid or alkali metal salts thereof include PPTA (phosphonopropane tricarboxylic acid) and PBTA (phosphonobutane-1,2,4-tricarboxylic acid) as acids or alkali metal salts, respectively. Polyolefin phosphates include those in which the olefin group contains two or more carbon atoms. Other useful materials include, for example, polyacrylates, maleic anhydride or acid copolymers and methyl vinyl ethers (eg, Gantrez) as described in US Pat. No. 4,627,977, and For example, polyaminopropane sulfonic acid (AMPS), zinc citrate trihydrate, polyphosphates (eg, tripolyphosphate; hexametaphosphate), diphosphonic acid esters (eg, EHDP, AHP), polypeptides (polyaspartic acid) And polyglutamic acid) and mixtures thereof, in addition, oral care compositions are described in US Pat. Nos. 6,682,722 and 6,589,512, and US patent applications. 10 / 424,640 and 10 / 430,617 Polymer carriers such as those can be included.

b-2) Tin ion source The oral care agent useful herein includes a tin ion source. Tin ions may be provided from stannous fluoride and / or other tin salts. Stannous fluoride has been found to be useful for gingivitis, plaque, reduced sensitivity, and improved breath benefits. The tin ions provided in the oral composition provide efficacy to the subject using the composition. Efficacy can include benefits other than reducing gingivitis, but efficacy is defined as the amount of significant reduction in in situ plaque metabolism. Formulations that provide such efficacy are typically provided by stannous fluoride and / or other tin salts, ranging from about 3,000 ppm to about 15,000 ppm tin ions throughout the composition. Includes tin concentration. Tin less than about 3,000 ppm is not sufficient for tin. Tin ions are present in an amount from about 4,000 ppm to about 12,000 ppm, and in one embodiment from about 5,000 ppm to about 10,000 ppm. Other tin salts include stannous acetate, stannous gluconate, stannous oxalate, stannous malonate, stannous citrate, stannous ethylene glycoloxide, stannous formate, stannous sulfate Organic stannous carboxylic acids such as stannous, stannous lactate, stannous tartrate and the like. Other tin ion sources include stannous chlorides, stannous bromides, stannous iodide, and tin halides such as stannous chloride dihydride. In one embodiment, the tin ion source is stannous fluoride, and in another embodiment, stannous chloride dihydrate. The combined tin salts may be present in an amount from about 0.001% to about 11% by weight of the composition. The tin salt is about 0.01% to about 7% by weight of the composition in one embodiment, about 0.1% to about 5% by weight in another embodiment, about 1.% by weight in another embodiment. It may be present in an amount of 5% to about 3% by weight.

b-3) Fluoride Ion Source Useful oral care agents herein include a fluoride ion source and provide an anti-caries effect. Included in these materials are soluble alkali metal fluoride salts, such as inorganic fluoride salts such as sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium hexafluorosilicate. Alkali metal fluorides such as sodium fluoride, sodium monofluorophosphate, sodium hexafluorosilicate and mixtures thereof are preferred.

  The amount of fluorine donor salt is generally present in the oral composition at a concentration of about 0.0 to about 3.0% by weight. Any suitable minimum amount of such salts may be used, but sufficient fluoride salt is used to release about 50 ppm to about 3500 ppm, preferably about 300 ppm to about 2,000 ppm fluoride ions. Is preferred.

b-4) Whitening Agent The oral care agent useful herein includes a whitening agent. Suitable active substances for whitening are alkali metal and alkaline earth metal peroxides, metal chlorites, perborates including mono- and tetrahydrates, perphosphates, percarbonate Selected from the group consisting of salts, peroxy acids, ammonium persulfate, potassium persulfate, alkali metal persulfates such as sodium persulfate and lithium persulfate, and mixtures thereof. Suitable peroxide compounds include hydrogen peroxide, urea peroxide, calcium peroxide, carbamide peroxide, magnesium peroxide, zinc peroxide, strontium peroxide, and mixtures thereof. In one embodiment, the peroxide compound is carbamide peroxide. Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite. Additional whitening actives may be hypochlorite and chlorine dioxide. In one embodiment, the chlorite is sodium chlorite. In another embodiment, the percarbonate is sodium percarbonate. In one embodiment, the persulfates are oxones. The concentration of these materials depends on the available oxygen or chlorine, respectively, that the molecule can provide to bleach the stain. In one embodiment, the whitening agent is from about 0.01% to about 40% by weight of the composition, in another embodiment from about 0.1% to about 20%, in another embodiment about 0%. It may be present at a concentration of from 5 wt% to about 10 wt%, in another embodiment from about 4 wt% to about 7 wt%.

b-5) Antibacterial agents The oral care agents useful herein include other antibacterial agents. Examples of the agent include 5-chloro-2- (2,4-dichlorophenoxy) -phenol, usually called triclosan; 8-hydroxyquinoline and its salts; copper chloride (II), copper sulfate (II), copper acetate (II ), Copper (II) fluoride and copper (II) hydroxide, including but not limited to copper II compounds; including those disclosed in US Pat. No. 4,994,262 including monopotassium magnesium phthalate Phthalic acid and salts thereof, including but not limited to: chlorhexidine; alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domifene bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); N-tetradecyl chloride -4-ethylpyridinium (TDEPC); octenidine (octe) iodine; sulfanilamides; bisbiguanides; phenols; delmopinol, octapinol and other piperidino derivatives; niacin formulations; zinc or tin ions such as zinc oxide, zinc lactate and zinc citrate Nystatin; grapefruit extract; apple extract; thyme oil; thymol; And fragrance oils containing thymol, geraniol, carvacrol, citral, hinokitiol, eucalyptol, catechol (particularly 4-allylcatechol) and mixtures thereof; Examples include, but are not limited to, methyl lithylate; hydrogen peroxide; metal salts of chlorous acid; and mixtures of all of the above. The antimicrobial component may be present from about 0.001% to about 20% by weight of the composition.

b-6) Anti-plaque Agents Oral care agents useful herein include other anti-plaque agents such as dimethyl isosorbide, copper salts, strontium salts, magnesium salts or dimethicone copolyol. The dimethicone copolyol is selected from C12 to C20 alkyl dimethicone copolyols and mixtures thereof. In one embodiment, the dimethicone copolyol is a cetyl dimethicone copolyol marketed under the trade name Abil EM90. The dimethicone copolyol in one embodiment is about 0.001% to about 25% by weight of the composition, in another embodiment about 0.01% to about 5%, in another embodiment about It can be present at a concentration of 0.1% to about 1.5% by weight.

b-7) Anti-inflammatory agents The oral care agents useful herein include anti-inflammatory agents. Such agents may include, but are not limited to, non-steroidal anti-inflammatory drugs oxicams, salicylates, propionic acids, acetic acids and phenamates. Such NSAIDs include ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, diclofenac, etodolac, indomethacin, sulindac, tolmetine, ketoprofen, fenoprofen, piroxicam, nabumetone, aspirin, diflunisal, meclofenamic acid, mefenamic acid , Oxyphenbutazone, phenylbutazone, and acetaminophen. The use of NSAIDs such as ketorolac is claimed in US Pat. No. 5,626,838. What is disclosed there is a method for preventing and / or treating primary and recurrent squamous cell carcinoma of the oral cavity or oropharynx by local administration of an effective amount of NSAID to the oral cavity or oropharynx. Suitable steroidal anti-inflammatory agents include corticosteroids such as fluccinolone and hydrocortisone.

b-8) Nutrients Oral care agents useful herein include nutrients that improve oral conditions. Nutrients include minerals, vitamins, oral nutritional supplements, enteral nutritional supplements, and mixtures thereof. Useful minerals include calcium, phosphorus, zinc, manganese, potassium, and mixtures thereof. Vitamins can be included with minerals or can be used separately. Suitable vitamins include vitamins C and D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids, and mixtures thereof. Oral supplements include amino acids, lipophilic substances, fish oils, and mixtures thereof. Amino acids include, but are not limited to, L-tryptophan, L-lysine, methionine, threonine, levocarnitine or L-carnitine and mixtures thereof. Lipophilic substances include, but are not limited to, choline, inositol, betaine, linoleic acid, linolenic acid, and mixtures thereof. Fish oil contains large amounts of omega-3 (N-3) polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid. Enteral nutritional supplements include, but are not limited to, protein products, glucose polymers, corn oil, safflower oil, and medium chain triglycerides. Minerals, vitamins, oral and enteral nutritional supplements, Drug Facts and Comparisons (loose leaf drug information service), St. Louis, Missouri ), Wolters Kluer Company (Copyright) 1997, pages 3-17 and 54-57.

b-9) Antioxidants The oral care agents useful herein include antioxidants. Antioxidants are disclosed in text by Cadenas and Packer et al., The Handbook of Antioxidants (Copyright) 1996 by Marcel Dekker, Inc. . Antioxidants useful in the present invention include vitamin E, ascorbic acid, uric acid, carotenoids, vitamin A, flavonoids and polyphenols, herbal antioxidants, melatonin, aminoindoles, lipoic acids and mixtures thereof. However, it is not limited to them.

b-10) Antiviral drugs Useful oral care agents herein include antiviral drugs used to treat viral infections. Examples of the antiviral drugs include phosphonoformic acid; cyosine derivatives; purine analogs such as adenosine, guanosine and inosine analogs; pyrimidine bases such as cytidine and thymidine; amantadine; rimantadine HCl Ribavirin; zanamivir; oseltamivir phosphate; trifluridine: heterocyclic dye Louis; acyclovir; famciclovir; valacyclovir; cidofovir; ganciclovir; levimisole ); Idoxuridine; lipophilic β-ketones; and thiosemicarbazones, but are not limited to. These antiviral drugs are drug Facts and Comparisons (loose leaf drug information service), St. Louis, Missouri, Wolters Kluer Company (Copyright) 2001, pages 1400-1423 (b) and Kirk-Othmer, Encyclopedia of Chemical Technology, 4th edition, Volume 3, Wiley-Interscience Publisher (Wiley-Interscience Publishers) (1992), pages 576-607.

b-11) Analgesics and Anesthetics Useful oral care agents herein include analgesics or desensitizers. An analgesic is an agent that relieves pain by acting centrally to raise the threshold of pain without disturbing consciousness or changing other sensory aspects. Such agents include: Strontium chloride; Potassium nitrate; Sodium fluoride; Sodium nitrate; Acetanilide; Phenacetin; Acertophan; Thiorphan; Spiradoline; Aspirin; Codeine; Thebaine; Oxymorphone; phenazosin; fentanyl; buprenorphine; butaphanol; nalbuphine; pentazocine; natural herbs such as gallic; asalum; cubine; galanga; scutaria; Is not limited. Anesthetics or topical analgesics such as acetaminophen, sodium salicylate, trolamine salicylate, lidocaine and benzocaine may also be present. These analgesic active agents are described by Kirk-Othmer, Encyclopedia of Chemical Technology, 4th edition, Volume 2, Wiley-Interscience Publishers (1992). ), Pages 729-737.

b-12) Zinc-Containing Layered Material The oral care agents useful herein are zinc-containing layered materials that have effective antibacterial and anti-gingivitis benefits due to high zinc reaction activity. In particular, these zinc-containing layered materials useful herein are those having a relative zinc reaction activity of greater than about 25% and have an average particle size of less than about 20 microns and a high surface area. In one preferred embodiment, the zinc-containing layered material herein is incorporated into a composition containing an anionic surfactant as discussed below.

  Zinc reaction activity is a measure of the chemical availability of zinc ions. Soluble zinc salts that do not complex with other species in solution, by definition, have a relative zinc reaction activity of 100%. When zinc salts in a somewhat soluble form are used and / or incorporated into the matrix with potential complexants, the zinc reaction activity generally decreases well below the defined 100% maximum. To do. Highly reactive zinc is maintained by selection of an effective zinc-containing layered material or by generating an effective zinc-containing layered material in situ by known methods.

  The zinc reaction activity is evaluated by combining a diluted zinc-containing solution or dispersion and the metal chromium dye xylenol orange (XO) and measuring the degree of color change under specific conditions. The magnitude of color formation is proportional to the concentration of zinc with high reaction activity. The developed procedure has been optimized for aqueous surfactant formulations, but can be applied to other physical product forms as well.

  A spectrophotometer is used to quantify the color change at 572 nm, the wavelength of the optimal color change for XO. The spectrophotometer utilizes a product control close to the composition of the test product, except for the potentially reactive form of zinc, and sets the absorbance at 572 nm to zero. Controls and test products are then treated similarly as follows. Dispense 50 μL of the product sample into a jar, add 95 mL of degassed distilled water and stir. Pipette 5 mL of 23 mg / mL xylenol orange stock solution at pH 5.0 and consider this time as zero. The pH is then adjusted to 5.50 ± 0.01 using dilute HCl or NaOH. After 10.0 minutes, a portion of the sample is filtered (0.45 μ) and the absorbance is measured at 572 nm. The measured absorbance is then compared to a separately measured control to determine relative zinc reaction activity (0-100%). A 100% reaction activity control is prepared in a matrix similar to the test product, except for the use of soluble zinc material (eg, zinc sulfate) incorporated at equal concentrations on a zinc basis. The absorbance of the 100% reaction activity control is measured as measured above for the test substance. The relative zinc reaction activity is preferably greater than about 15%, more preferably greater than about 20%, and even more preferably greater than about 25%.

Using this method, the following examples show a material (basic carbonic acid) that has an intrinsically high reaction activity in an anionic surfactant system compared to a material with a low intrinsic reaction activity (ZnO). Zinc) is demonstrated.

  Zinc-containing layered structures have crystal growth that occurs primarily in two dimensions. It is customary for the layer structure not only to have all atoms incorporated into a well-defined layer, but also to have ions or molecules between the layers, called gallery ions ( AF Wells, “Structural Inorganic Chemistry”, Clarendon Press, 1975). The zinc-containing layered material (ZLM) may have zinc incorporated into the layer and / or may be a component of gallery ions.

  Many ZLMs occur naturally as minerals. Common examples include hydrozinc ore (zinc carbonate hydroxide), basic zinc carbonate, hydrozinc copper ore (zinc carbonate carbonate), zinc peacock stone (zinc carbonate copper), and many Related minerals. Natural ZLM can also be generated, where anionic layer species such as clay-type minerals (eg phyllosilicates) contain ion exchanged zinc gallery ions. All of these natural materials can also be obtained synthetically or can be generated in situ in the composition or during the manufacturing process.

  Another common type of ZLM, which is often synthetic but not necessarily synthetic, is a double layered hydroxide, generally of the formula [M2 + 1−xM3 + x (OH) 2] x + Am−x / m · nH20 And some or all of the divalent ions (M2 +) are represented by zinc ions (EL. Crepaldi, PC. Pava, J. Toronto, JB. Valim). , J. Colloid Interfac. Sci. 2002, 248, 429-42).

  Still other types of ZLM, referred to as hydroxy double salts, can be prepared (H. Morioka, H., H. Tagaya, H., M. Karasu, M., J. Am. Kadokawa, J, K. Chiba, K, Inorganic Chemistry (Inorg. Chem.), 1999, 38, 4211-6). Inorganic chemistry (Inorg. Chem.), 1999, 38, 4211-6). The hydroxy double salt has the general formula [M2 + 1−xM2 + 1 + x (OH) 3 (1-y)] + An− (1 = 3y) / n · nH20 (wherein the two metal ions may be different and they are the same When expressed in zinc, the formula can be expressed as [Zn1 + x (OH) 2] 2x + 2xA-.nH20). This latter formula (where x = 0.4) represents general substances such as hydroxy zinc chloride and hydroxy zinc nitrate. These are also related to hydrozincite, where the divalent anion replaces the monovalent anion. These materials can also be generated in the composition in situ or during the manufacturing process.

  These types of ZLM represent a relatively general example of the general category, but are not intended to be a limitation on a wider range of materials that meet this definition.

  Commercial sources of basic zinc carbonate include: Zinc Carbonate Basic (Cater Chemicals: Bensenville, Ill., USA), Zinc Carbonate (Shepherd Chemicals): Norwood, Ohio, Zinc Carbonate (CPS Union Corp .: New York, NY), Zinc Carbonate (Elementis Pigments: Durham, UK), and Zinc Carbonate AC (Bruggemann Chemical: Newtown Square, Pennsylvania, USA).

  Basic zinc carbonate is also sometimes referred to commercially as “zinc carbonate” or “zinc carbonate base” or “hydroxy zinc carbonate”, but is a synthetic class consisting of materials similar to naturally occurring hydrozincite. is there. The ideal stoichiometry is represented by Zn5 (OH) 6 (CO3) 2, but the actual stoichiometric ratio may vary slightly and other impurities may be incorporated into the crystal lattice. .

c) Polar Solvent Carrier The composition of the present invention comprises a polar solvent carrier to provide the essential ingredients and impart suitable rheology to the binder system. The polar solvent also serves as a solvent for incorporating the water soluble oral care active and other components.

  The polar solvent comprises about 1% to about 95%, preferably about 30% to about 70% by weight of the total composition.

  Polar solvents useful herein include water, polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, hexylene glycol, propanediol, ethylene glycol, diethylene glycol, dipropylene glycol, diglycerin, Sorbitol and other saccharides in liquid form at ambient temperature. Also useful herein are water soluble alkoxylated nonionic polymers such as polyethylene glycol.

  In one preferred embodiment, the composition can include a relatively high level of water to provide a cost effective product. In such preferred embodiments, the water is comprised of about 30% to about 95%, more preferably about 50% to about 70% of the total composition.

  Commercially available polar solvents herein include glycerin available from Asahi Denka; propylene glycol having the trade name LEXOL PG-865 / 855 available from Inolex; obtained from BASF Possible 1,2-propylene glycol USP; 1,3-butylene glycol available from Daisel Kagaku Kogyo; dipropylene glycol with the same trade name available from BASF; Solvay GmbH Diglycerin with the trade name DIGLYCEROL available from; polyethylene glycol with the trade name PEG300 available from Doe Chemical Company; and Khalista (Liuzhou) Chemical Industries (Ch sorbitol 70% solution available from emical Industries, Ltd.).

Abrasives The compositions of the present invention are low level or substantially free of abrasives, preferably from 0% to about 10% abrasives.

  In one preferred embodiment, the composition is substantially free of abrasive. That is, the composition of the present invention does not have an intentionally contained abrasive. Surprisingly, embodiments of the present composition without abrasives are conventional dentifrice compositions including those typically due to the use of abrasives such as cleaning, stain removal, plaque removal, tartar removal and the like. Found that can provide the benefits. The absence of abrasives accommodates the inclusion of certain active agents such as cetylpyridinium chloride, otherwise it is poorly compatible with abrasives such as silica and therefore cannot be included in dentifrice compositions. Furthermore, since there is no abrasive, various aesthetics of toothpaste products can be pursued. For example, a composition having a transparent appearance can be produced.

  An abrasive within the context of the present composition is defined as a material having a DOA value of about 150 mL / 100 g or less, preferably about 100 mL / 100 g or less and a particle size of about 5 μm to about 50 μm. The abrasive herein is distinguishable from those materials useful herein as binders.

  As abrasives in this specification, inorganic minerals such as silica gels and precipitates; aluminas; hydrated alumina; calcium carbonate; titanium dioxide: talc, calcium dioxide; calcium carbonate; and fine particle condensation products of urea and formaldehyde These resinous abrasives can be mentioned.

Phytic Acid Compound The composition of the present invention may further comprise a phytic acid compound in an amount that provides effective cleaning for the teeth. Phytic acid, also known as myo-inositol hexaphosphate or inositol hexaphosphoric acid, is a natural form of biodegradable chelating agent in liquid form with chelating performance comparable to that of EDTA. Plant origins from which phytic acid compounds can be found include cereal grains, legumes, nut oil seeds, pollen, spores and organic soils.

  The phytic acid compound herein may be phytic acid itself and / or its orally acceptable salts, including but not limited to alkali metal salts and alkaline earth metal salts. Useful phytate salts include sodium phytate, potassium phytate, magnesium phytate, calcium phytate, tin phytate, zinc phytate, copper phytate, iron phytate and mixtures thereof.

  Surprisingly, the phytic acid compound provides a good cleansing effect that is not noticeable to consumers in compositions that do not have this low abrasive or abrasive, and this polar solvent carrier as well as a wide range of oral care It has been found that it is compatible with the active substance component. Without being bound by theory, it appears that phytic acid compounds provide unique good cleansing due to their liquid form by flowing between the teeth. Such a flow would provide cleaning in a sense different from a solid abrasive. Furthermore, phytic acid compounds appear to provide a clear and anticalculus effect that protects tooth enamel from acid dissolution.

  Commercially available phytic acid compounds useful herein include phytic acid available from Sichuan Chengdu Yason, Shikishima Starch Manufacturing Company and Nibbio. Examples include solutions, sodium phytate, magnesium phytate, calcium phytate, and tin phytate.

Additional Components The composition of the present invention may contain other additional components, which may be selected by those skilled in the art depending on the desired properties of the final product, which makes the composition more cosmetic or aesthetic. It is suitable for making the composition acceptable and providing the benefits of additional use to the composition. These additional components are each typically used at a concentration of about 5% or less by weight of the composition.

  Surfactants may be incorporated into the components of the present invention as ingredients to help adequate dispersion of the dentifrice throughout the oral cavity and improve cosmetic acceptability and foamability when applied to the oral cavity. . Surfactants that can be included in the composition include anionic, nonionic or amphoteric compounds, with anionic compounds being preferred.

  Suitable examples of anionic surfactants include higher alkyl sulfates such as potassium lauryl sulfate or sodium lauryl sulfate, and higher fatty acid monoglyceride monohydrates such as salts of monosulfated monoglycerides of hydrogenated coconut oil fatty acids, which are preferred Sulfates, alkyl sulfonates such as sodium dodecylbenzenesulfonate, higher fat sulfoacetates, and higher fatty acid esters of 1,2 dihydroxypropane sulfonate.

  Examples of amphoteric surfactants are alkylated betaine products such as cocamidopropyl betaine with the trade name TEGO Betaine ZF from Goldschmidt Chemical Corp.

  Examples of water-soluble nonionic surfactants are condensation of ethylene oxide with various hydrogen-containing compounds that are easy to react with it and have a long hydrophobic chain (eg, an aliphatic chain of about 12-20 carbon atoms). Products, such as Pluronic materials such as Pluronic F127, which condensation products contain fatty acids, fatty alcohols, fatty acid amides and other fatty acid moieties and propylene oxide and polypropylene oxides. It contains a hydrophilic polyoxyethylene moiety such as a poly (ethylene oxide) condensation product.

  The surfactant can be present in the composition at a concentration of about 0.5 to about 10.0% by weight, preferably about 1 to about 2% by weight.

  Other ingredients that may be incorporated into the dentifrice constituents of the present invention include pigments, dyes, flavors and sweeteners. For example, strip products are obtained according to the invention, in which a contrasting colorant is incorporated into each of the components used in the practice of the invention, where the colorant is used in the proposed amount. It is harmless pharmacologically and physiologically. Colorants used in the present invention include both pigments and dyes.

  Useful pigments for the present invention include harmless titanium dioxide and chromium oxide green, ultramarine blue and pink, water-insoluble inorganic pigments such as ferric trioxide, FD & C green # 1 lake, FD & C blue # 2 lake, Water-insoluble dye lakes prepared by extending calcium or aluminum salts of FD & C dyes such as FD & C R & D # 30 lake, FD & C # 5 yellow and FD & C yellow # 15 lake onto aluminum. The concentration of the dye in the composition is about 3% by weight or less. The pigments herein are distinguished from abrasives and the pigments herein have a particle size in the range of 100 to about 1,000 microns, preferably about 250 to about 500 microns, so that the composition is substantially There is no abrasive material. When present, pigments are included in the composition at about 0.5 wt% to about 3 wt%.

  Any suitable flavoring or sweetening material may be incorporated into the components of the present invention. Examples of suitable flavor components are flavor oils such as spearmint, peppermint, winter green oil, sassafras, cloves, sage, eucalyptus, marjoram, cinnamon oil, lemon, orange and methyl salicylate. Suitable sweetening agents include sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, perillartine and sodium saccharin. Both flavor and sweeteners may suitably comprise from 0.01% to 5% by weight or more of the preparation.

  Buffering agents such as monosodium phosphate and trisodium phosphate, enzyme inhibitors, plant extracts, natural herbal extracts and others may be included.

The following dentifrice composition is formed by the following components using the preparation methods described herein.

Definition of components
^* 1 Sodium fluoride: NaF, available from Jinan Chemical Industry Co. Ltd.
^* 2 Sorbitol (70% solution): 70% sorbitol solution, available from Khalista (Liuzhou) Chemical Industries, Ltd.
^* 3 Glycerin 99.5%: Available from Glycerin Asahidenka
^* 4 Polyethylene glycol: PEG-300, available from Doe Chemical Company
^* 5 Sodium lauryl sulfate (28% solution): SLSS, available from Rhodia Specialty Chemical Wuxi Co. Ltd.
^* 6 Sodium carboxymethyl cellulose: CMC, available from Sanhui Chemical Industry Co., Ltd., Zhangjiagang city
^* 7 Hydroxyethyl cellulose: available from NATROSOL Hercules
^* 8 Carbopol: Carbomer 956, available from Noveon, Inc.
^* 9 Xanthan gum: available from KELDENT, CP Kelco Inc.
^* 10 From the gellan gum-CP Kelco Inc. under the trade name KELCOGEL series
^* 11 Carrageenan: GELCALIN TP911 Available from FMC Corporation's Food Ingredients Division
^* 12 Synthetic layered magnesium silicate 0.2% fluoride: Laponite DF, available from Rockwood Additives Limited
^* 13 Synthetic layered magnesium silicate: Laponite D, available from Rockwood Additives Limited
^* 14 Amorphous precipitated silica: Zeodent 165; M.M. Available from Huber Company
^* 15 Fumed silica: available from Aerosol, Cabot & Degussa Corporation
^* 16 Precipitated silica-abrasive: Zeodent 119 and Zeodent 109 M.M. Available from Huber Company
^* 17 Mica, titanium dioxide coating: available from Rona
^* 18 Sodium hydroxide solution (50%): NaOH 50%, available from Guangzhou Chemical Company
^* 19 Tetrasodium pyrophosphate: Sodium pyrophosphate, tetra (anhydrous), available from Lianyungang Duoling Fine Chemical Co. Ltd.
^* 20 Sodium phosphate, monobasic, monohydrate: MSP, available from Jiangsu Chengxing Phosphate Chemical Co. Ltd
^* 21 Tribasic sodium phosphate: TSP, available from Jiangsu Jiangyin Phosph Chemicals
^* 22 Sodium phytate 20% solution: available from Sichuan Chengdu Yason
^* 23 Saccharin sodium: available from Suzhou Fine Chemical
^* 24 Stannous fluoride: SnF2, available from Hashimoto
^* 25 Cocamidopropyl betaine 30% solution: available from TEGO Betaine ZF Goldschmidt Chemical Corp.
^* 26 Triclosan: available from Ciba-Geigy Chemicals Ltd.
^* 27 Cetylpyridinium chloride: available from Cambrex company
^* 28 Zinc carbonate: available from Bruggemann Chemical
^* 29 Dimethylisosorbide: available from Arlasolve DMI Uniqema

Preparation Method The dentifrice compositions of Examples 1 to 10 can be prepared by any method known to those skilled in the art, and are preferably prepared as follows.

  First, a hydrophilic clay material (component Nos. 12 to 14) is dispersed in a portion of water in a container at room temperature, and mixed using a propeller mixer (Propeller Mixer) until homogeneous. In another major mix spot, sorbitol (component number 2), glycerin (component number 3), polyethylene glycol (component number 4), sodium hydroxide solution (component number 18), present in the composition Sometimes the dyes and pigments (component number 17) and the rest of the water are mixed together with the composition and at a high temperature and a rotational speed of 2.6 radians / second (25 rpm) to 3.7 radians / second (35 rpm) Mix together with a stirrer.

  Add all remaining components except the flavor and surfactant (component numbers 5 and 25) to the main mix spot. The pot is hermetically closed, a vacuum of about 13.3 kPa (100 mmHg) is created, and the homogenizer is rotated at a rotational speed of 251.3 radians / second (2400 rpm) to 366.5 radians / second (3500 rpm). The resulting mixture is further degassed.

  To this is added the mixture made in the first step. The resulting mixture is mixed and degassed. Finally, flavors and surfactants (component numbers 5 and 25) are added and the pot is again airtight and closed to finally homogenize from 2251.3 radians / second (2400 rpm) to 366.5 radians / Mix with a homogenizer rotating at a rotation speed of 2 seconds (3500 rpm) and degas.

  The resulting product is pumped out of the container and delivered to the primary packaging such as a laminate tube.

  The example compositions herein have many benefits that are suitable for dentifrice products. All compositions have a viscosity of 10,000-45,000 Pa and provide less wear on the tooth surface compared to toothpaste containing more than 10% abrasive and safer for tooth enamel It is. All compositions provide a soft mouth feel, easier dispersion, and improved penetration into the interdental area compared to toothpastes containing abrasives. All compositions are better perceivable by consumers compared to toothpastes containing the same level of abrasive and the same flavoring. Furthermore, all compositions can be manufactured at an economical cost. The compositions of Examples 1-2 provide anti-caries, anti-plaque, whitening, anti-calculus and anti-gingivitis effects. The compositions of Examples 3-5, 7, and 10 provide anti-caries, anti-plaque, whitening, and anti-calculus effects. The composition of Example 6 provides anti-caries, anti-plaque and whitening effects. The compositions of Examples 8-9 provide anti-caries, anti-plaque, whitening, anti-calculus and antibacterial effects.

  The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as “40 mm” is intended to mean “about 40 mm”.

  All documents cited in “Best Mode for Carrying Out the Invention” are incorporated herein by reference in the relevant part, but any citation of any document is prior art to the present invention. It should not be interpreted as acceptance. To the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of a term in a document incorporated by reference, the meaning or definition given to that term in this document applies And

  While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Accordingly, it is intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims (14)

(A)
i) hydrophilic clay material;
ii) modified cellulose polymers;
iii) a carboxyvinyl polymer; and iv) a binder system having a viscosity of about 10,000 Pa to about 450,000 Pa, comprising natural rubber-derived anionic polymers;
(B) an effective amount of an oral care active; and (c) a dentifrice composition comprising a polar solvent carrier.   The dentifrice composition of claim 1, wherein the composition comprises 0% to about 10% abrasive.   The dentifrice composition according to claim 1, further comprising a phytic acid compound.   The dentifrice composition according to claim 1, wherein the hydrophilic clay material is selected from the group consisting of natural and synthetic layered silicate minerals, fumed silicas, concentrated precipitated silica, and mixtures thereof.   The dentifrice composition according to claim 3, wherein the hydrophilic clay material is synthetic layered magnesium silicate. About 0.1% to about 10% of the binder system, the binder system comprising:
i) about 0.01% to about 5% of said hydrophilic clay material;
ii) about 0.01% to about 5% of the modified cellulose polymer;
The dentifrice composition of claim 1, comprising iii) about 0.01% to about 5% of said carboxyvinyl polymer; and iv) about 0.01% to about 5% of said natural rubber-derived anionic polymers. object.   The oral care active substance is an anticalculus agent, a tin ion source, a fluoride ion source, a whitening agent, an antibacterial agent, an anti-plaque agent, an anti-inflammatory agent, a nutrient, an antioxidant, The dentifrice composition of claim 1 selected from the group consisting of viral drugs, analgesics and anesthetics, zinc-containing layered materials, and mixtures thereof.   The dentifrice of claim 7, wherein the oral care active is selected from the group consisting of fluoride ion sources, tin ion sources, pyrophosphates, polyphosphates, hydrogen peroxide, triclosan, and mixtures thereof. Agent composition.   The dentifrice composition according to claim 7, wherein the oral care active substance is an anti-dental active substance selected from the group consisting of cetylpyridinium chloride, tin ion sources, and mixtures thereof.   The dentifrice composition of claim 7, wherein the oral care active is a zinc-containing layered material having a relative zinc response activity of greater than about 25%.   The zinc-containing layered material is basic zinc carbonate, zinc carbonate hydroxide, zinc carbonate hydroxide, hydrozinc copper ore, copper carbonate zinc hydroxide, zinc peacock stone, zinc ion-containing phyllosilicate, layered double hydroxide, hydroxyl The dentifrice composition according to claim 10, selected from the group consisting of double salts and mixtures thereof.   The dentifrice composition according to claim 11, wherein the zinc-containing layered material is basic zinc carbonate.   The dentifrice composition of claim 1, wherein the polar solvent carrier comprises from about 30% to about 95% water by weight of the total composition.   A method of cleaning teeth without the use of abrasives, comprising brushing teeth with the dentifrice composition of claim 1, wherein the composition is substantially free of abrasives.