JP2009504793A5 - - Google Patents

Info

Publication number

JP2009504793A5

JP2009504793A5 JP2008527372A JP2008527372A JP2009504793A5 JP 2009504793 A5 JP2009504793 A5 JP 2009504793A5 JP 2008527372 A JP2008527372 A JP 2008527372A JP 2008527372 A JP2008527372 A JP 2008527372A JP 2009504793 A5 JP2009504793 A5 JP 2009504793A5

Authority

JP

Japan

Prior art keywords

formula

phenyl

compound

azabicyclo

hex

Prior art date

2006-08-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 33
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 17
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 14
• 125000000217 alkyl group Chemical group 0.000 claims 10
• 229910052739 hydrogen Inorganic materials 0.000 claims 10
• 239000001257 hydrogen Substances 0.000 claims 10
• 150000002431 hydrogen Chemical class 0.000 claims 8
• 150000003839 salts Chemical class 0.000 claims 6
• 239000011780 sodium chloride Substances 0.000 claims 6
• 125000006239 protecting group Chemical group 0.000 claims 5
• 125000003545 alkoxy group Chemical group 0.000 claims 4
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 4
• 125000001424 substituent group Chemical group 0.000 claims 4
• HNEGJTWNOOWEMH-UHFFFAOYSA-N 1-fluoropropane Chemical group [CH2]CCF HNEGJTWNOOWEMH-UHFFFAOYSA-N 0.000 claims 2
• 206010036596 Premature ejaculation Diseases 0.000 claims 2
• 206010061920 Psychotic disease Diseases 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 229960003638 dopamine Drugs 0.000 claims 2
• 229910052736 halogen Inorganic materials 0.000 claims 2
• 150000002367 halogens Chemical class 0.000 claims 2
• VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
• 230000003647 oxidation Effects 0.000 claims 2
• 238000007254 oxidation reaction Methods 0.000 claims 2
• 201000000980 schizophrenia Diseases 0.000 claims 2
• 201000009031 substance-related disease Diseases 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 125000004434 sulfur atoms Chemical group 0.000 claims 2
• -1 2-propen-1-yl Chemical group 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 150000001408 amides Chemical class 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000005843 halogen group Chemical group 0.000 claims 1
• 239000008079 hexane Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 230000001105 regulatory Effects 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1