JP2009501516A5 - - Google Patents
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- Publication number
- JP2009501516A5 JP2009501516A5 JP2008520763A JP2008520763A JP2009501516A5 JP 2009501516 A5 JP2009501516 A5 JP 2009501516A5 JP 2008520763 A JP2008520763 A JP 2008520763A JP 2008520763 A JP2008520763 A JP 2008520763A JP 2009501516 A5 JP2009501516 A5 JP 2009501516A5
- Authority
- JP
- Japan
- Prior art keywords
- kinase
- dye
- tyrosine
- unique
- kinase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000975 dye Substances 0.000 claims 23
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 16
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 229940043355 kinase inhibitor Drugs 0.000 claims 14
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 14
- 108091000080 Phosphotransferase Proteins 0.000 claims 10
- 102000020233 phosphotransferase Human genes 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 7
- 230000006698 induction Effects 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 6
- 239000012190 activator Substances 0.000 claims 4
- 239000007850 fluorescent dye Substances 0.000 claims 4
- DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 claims 4
- 150000003668 tyrosines Chemical class 0.000 claims 4
- 230000035578 autophosphorylation Effects 0.000 claims 3
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091008324 binding proteins Proteins 0.000 claims 2
- 239000013592 cell lysate Substances 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 235000003642 hunger Nutrition 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 230000037351 starvation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05015493 | 2005-07-16 | ||
| EP05015493.9 | 2005-07-16 | ||
| PCT/EP2006/006642 WO2007009613A1 (en) | 2005-07-16 | 2006-07-07 | Method for measuring tyrosine kinase phosphorylation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009501516A JP2009501516A (ja) | 2009-01-22 |
| JP2009501516A5 true JP2009501516A5 (enExample) | 2009-09-03 |
| JP5524481B2 JP5524481B2 (ja) | 2014-06-18 |
Family
ID=37434211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008520763A Expired - Fee Related JP5524481B2 (ja) | 2005-07-16 | 2006-07-07 | チロシンキナーゼリン酸化の測定方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7981633B2 (enExample) |
| EP (1) | EP1904842A1 (enExample) |
| JP (1) | JP5524481B2 (enExample) |
| AU (1) | AU2006272094B2 (enExample) |
| CA (1) | CA2615233C (enExample) |
| WO (1) | WO2007009613A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5392992B2 (ja) * | 2007-03-30 | 2014-01-22 | アズワン株式会社 | 自己リン酸化受容体のアゴニスト、アンタゴニストのスクリーニング方法、遺伝子組換え酵母 |
| CA2733672C (en) * | 2007-08-16 | 2018-09-11 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| US20100255514A1 (en) * | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| WO2009119502A1 (ja) * | 2008-03-28 | 2009-10-01 | シスメックス株式会社 | 腫瘍細胞の悪性度の評価方法 |
| EP2353003A4 (en) * | 2008-11-06 | 2012-05-30 | Ambit Biosciences Corp | BIOMARKER ASSAY OF TYROSINE KINASE 3 RELATED TO FMS PHOSPHORYLÉE |
| EP3126843A1 (en) * | 2014-03-31 | 2017-02-08 | Merck Patent GmbH | Method for detecting protein modifications using specific antibodies |
| CN113186296B (zh) * | 2021-07-01 | 2021-10-26 | 中国医学科学院肿瘤医院 | 黏着斑激酶剪接异构体及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355636B1 (en) * | 1999-04-21 | 2002-03-12 | American Cyanamid Company | Substituted 3-cyano-[1.7],[1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases |
| US20040229284A1 (en) * | 2003-02-19 | 2004-11-18 | The Regents Of The University Of California | Multiplex analysis of proteins |
| US7189694B2 (en) | 2003-04-18 | 2007-03-13 | University Of Florida Research Foundation, Inc. | Inhibitors of autophosphorylation protein kinases |
| EP1664716A4 (en) * | 2003-08-15 | 2008-08-13 | Smithkline Beecham Corp | CANCER BIOMARKERS |
| DE102005020754B3 (de) * | 2005-05-02 | 2007-01-11 | Altana Pharma Ag | Zelluläres Assayverfahren zur Identifizierung von PKCtheta-Inhibitoren |
| US20080026485A1 (en) * | 2006-04-18 | 2008-01-31 | Wolfgang Hueber | Antibody profiling for determination of patient responsiveness |
-
2006
- 2006-07-07 WO PCT/EP2006/006642 patent/WO2007009613A1/en not_active Ceased
- 2006-07-07 US US11/995,742 patent/US7981633B2/en not_active Expired - Fee Related
- 2006-07-07 CA CA2615233A patent/CA2615233C/en not_active Expired - Fee Related
- 2006-07-07 JP JP2008520763A patent/JP5524481B2/ja not_active Expired - Fee Related
- 2006-07-07 EP EP06776140A patent/EP1904842A1/en not_active Ceased
- 2006-07-07 AU AU2006272094A patent/AU2006272094B2/en not_active Ceased
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