JP2009226042A - Body fluid sampling device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To airtightly and less-invasively sample a body fluid concerning a body fluid sampling device for sampling the body fluid by obtaining a very small opening formed by inserting a needle into the surface of a living body or irradiating laser light, etc. <P>SOLUTION: A hat shape support member 20 incorporating a mobile member 50 is made to adhere onto the surface of the living body, and a laser irradiator 30 is mounted on the member 20. The very small opening is formed in a state where the through-hole 53 of the mobile member 50 is made to face a laser light source 31 by a moving means 60. Then, the moving means 60 is operated, while keeping the support member 20 as it is, thereby sucking out the body fluid effused by a pump to a measurement device in a state where the suction chamber 54 of the mobile member 50 is made to face the very small opening. Consequently, processing from the formation of the very small opening to the sampling of the body fluid is performed by a series of operations without removing a device, and the suction chamber 54 is arranged at the very small opening without a deviation, so that a work is airtightly performed. Besides, the suction chamber 54 is independently arranged from the through-hole 53, so that the suction chamber 54 is made to have the minimum capacity so as to less-invasively perform sampling. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a bodily fluid collection device that collects bodily fluids such as cell interstitial fluid and blood by perforating micro openings on the surface of a living body with laser light or the like.

  The most common method for collecting body fluid from a living body is to collect blood with an injection needle. However, there are problems such as anxiety and pain of the patient, and infection by bacteria attached to the injection needle. In addition, for example, in order to see the progress after the operation, it is necessary to puncture the body with an injection needle every time when collecting continuously, as in the case of monitoring the glucose concentration (blood glucose level) every 30 minutes or every hour. Yes, the skin became stiff and the burden on the patient was excessive.

  Therefore, in order to reduce such a burden, a method of collecting cell interstitial fluid instead of blood has attracted attention in recent years. This is a minute opening that does not reach the dermis layer through which blood vessels pass, but the interstitial fluid that exudes from there is almost the same component as blood except that there are no blood cells. This is because it is an alternative to a blood test, and there is no (less) pain during perforation.

  Patent Document 1 proposes a tissue interface device that covers a minute opening formed on the surface of a living body with a separate device, sucks body fluid from the opening portion on the bottom surface, and performs various measurements with a sensor provided on the orifice portion. Has been. However, in this prior art, the device for perforating the microscopic aperture and the device for sucking the body fluid are separate from each other, and therefore there is a problem that measurement cannot be performed unless the device is accurately positioned with respect to the microscopic aperture created. is there. Also, the work is complicated.

  Therefore, in order to solve such a problem, in Patent Document 2, an alignment device serving as a base member is positioned at a desired position on the surface of a living body, and a perforation device and a sensor device are replaced and attached to the alignment device. This improves the reliability of continuous monitoring.

On the other hand, in Patent Document 3, an exchange chip having a pair of enzyme electrodes is arranged at the bottom around an opening, and a living body surface is irradiated with laser light from a laser source provided at the top through the opening. There has been proposed a biological measurement apparatus that detects the glucose concentration of body fluid that has oozed out from the minute opening using the enzyme electrode.
Special table 2003-514244 gazette Special table 2003-501222 gazette JP 2003-265444 A

  In the prior art of Patent Document 2, as with the prior art of Patent Document 1, the perforation device is removed, and the sensor device is attached to perform sampling. There is a problem of deterioration.

  The conventional technique of Patent Document 3 has a problem that the volume of the suction chamber is large and a large force is required when sucking the body fluid, so that the work cannot be performed with minimal invasiveness.

  An object of the present invention is to provide a bodily fluid collecting device capable of collecting bodily fluids from a perforated micro opening in an airtight and minimally invasive manner.

  The bodily fluid collection device of the present invention is a bodily fluid collection device that collects bodily fluid by drilling, for example, by irradiating the surface of a living body with laser light, and collecting the bodily fluid. A support member that is installed in close contact with the surface of the living body with the bottom open, and the device or energy source is mounted on the top surface; and a device or energy that is housed in the support member and forms the micro-openings. A moving member in which a path that can pass through and a suction chamber that covers the minute opening are arranged in parallel with the surface of the living body, a suction unit that is connected to the suction chamber and sucks a body fluid, and the movement It is characterized in that the member is provided with proximity and separation displacement with respect to the living body surface and moving means for displacing the member substantially parallel to the living body surface in the support member.

  According to the above configuration, when the body surface is collected by piercing the surface of the living body with a needle or irradiating a laser beam to collect a body fluid, the bottom surface is opened like a cap and has a flange, etc. In addition, a support member serving as a base member can be installed in close contact with the surface of the living body, and an energy source such as an instrument or laser source for forming the minute opening on the top surface is mounted. In addition, a moving member is provided in the support member, and the moving member can be displaced in the support member in the vicinity of and away from the living body surface and substantially parallel to the living body surface by the moving means. The moving member includes a path through which an instrument (such as the needle) or energy (such as the laser beam) for forming the minute opening can pass and a suction chamber that covers the minute opening. While being arranged in parallel with the surface, a suction means for sucking the exuded body fluid is connected to the suction chamber.

  Therefore, the user first forms the minute opening in a state where the path of the moving member faces the instrument or the energy source, and the moving member is once lifted (separated) from the living body surface without changing the supporting member. Moved substantially parallel to the surface, lowered (closed) with the suction chamber facing the formed micro-opening to bring the moving member into close contact with the surface of the living body, and the suction means creates a negative pressure in the suction chamber, The exuded body fluid is supplied to the measuring device or soaked into the test paper to enable measurement with a separate measuring device.

  As a result, it is possible to perform a series of operations from removing the microscopic opening to collecting the body fluid without removing the device, and without shifting the suction chamber that requires precise positioning with respect to the perforated microscopic opening. In addition to being able to be installed, the work can be performed in an airtight manner, so that it is possible to prevent infection and bacteria quality deterioration due to bacteria entering from the outside during the work. In addition, since the suction chamber and the path are formed separately, the suction chamber can be set to a minimum volume, and a necessary amount of body fluid can be collected in a short time with a weak suction force. Body fluid can be collected in a minimally invasive manner without damaging the device, and the body fluid collecting device can be miniaturized in combination with making the instrument or the energy source for forming the microscopic opening detachable. .

  In the bodily fluid sampling device of the present invention, a laser light source is used as an energy source for forming the minute opening.

  According to said structure, there is less pain compared with a needle | hook, and it is hygienic.

  Furthermore, in the body fluid sampling device of the present invention, an absorber that generates heat by absorbing the laser light is provided at the end of the path of the moving member.

  According to the above configuration, when forming the minute opening on the surface of the living body, the laser light is absorbed by the absorber even if it is not directly absorbed by the surface of the living body. Can be formed.

  Therefore, a laser light source can be arbitrarily selected, a minute opening having a required size and depth can be created with a minimum power, and the laser light source can be miniaturized.

  In the bodily fluid sampling device of the present invention, an optical member that shifts the optical path from the center of the path is provided between the laser light source and the path of the moving member, and the optical member is configured to change the incident optical axis. It further comprises a rotating means for rotating about the rotation center.

  According to said structure, when using a laser light source as an energy source which forms the said micro opening, an optical member, such as a prism, is interposed between this laser light source and the said path | route of the said moving member, and an optical path is said A plurality of the minute apertures can be formed by shifting the optical member from the center of the path and rotating the optical member about the incident optical axis with the rotation means.

  Therefore, more body fluid can be collected in the same time, or the same amount of body fluid can be collected in a shorter time.

  Furthermore, in the body fluid sampling device of the present invention, the laser light source can be removed from the support member, and positioning means for mutual positioning is provided between the laser light source and the support member, and the laser light source On the side, a locking mechanism is provided that prohibits the emission of the laser beam when positioning is not performed.

  According to the above configuration, the laser light source can be removed from the support member, so that the troublesomeness can be eliminated when the laser light source is collected for a long time, and the laser light source is shared by a plurality of patients. Can be possible. And even if it can be removed in this way, a minute opening can be formed accurately at a predetermined position by providing positioning means for positioning each other. Further, a locking mechanism is provided on the laser light source side, and if the locking mechanism is not positioned by the positioning means, the laser beam is prohibited from being emitted, so that the leakage of the laser beam can be prevented and safety can be prevented. Can be improved.

  In the bodily fluid collection device of the present invention, the suction chamber is formed in a dome shape, and a suction port to the suction means is provided at the top.

  According to the above configuration, since the suction chamber is formed in a dome shape, the surface of the living body is slightly raised along the inner surface by the suction action of the suction means, and the suction port provided at the top and the micro opening The distance gets closer.

  Therefore, the body fluid can be sucked up efficiently.

  Furthermore, the bodily fluid collecting device of the present invention is characterized in that a resin stopper capable of being pierced is installed in a part of a conduit from the suction chamber to the suction means.

  According to the above configuration, the pipe between the suction chamber and the suction means is provided with a pierceable resin stopper, and the body fluid can be sucked into another pipe by piercing it with an injection needle. it can.

  Therefore, it can be used for a detection device that cannot place the collected body fluid near the patient or a detection device that cannot be incorporated in the body fluid collection device.

  As described above, the bodily fluid collecting device of the present invention forms a microscopic opening by puncturing a needle on the surface of a living body or irradiating a laser beam, etc., and the bottom is opened like a cap when collecting bodily fluids. In addition, a tool or a laser source that can be installed in close contact with the surface of the living body by having a flange or the like, a support member serving as a base member is installed in close contact with the surface of the living body, and the micro opening is formed on the top surface thereof. In addition to mounting an energy source, a moving member is provided in the support member, and the moving member can be displaced close to and away from the living body surface and substantially parallel to the living body surface by the moving means. And a path through which an instrument (such as the needle) or energy (such as the laser beam) for forming the minute opening can pass through the moving member; With a suction chamber covering the mouth should be located side by side substantially parallel to the said living body surface, wherein the suction chamber is kept connected to a suction means for sucking a body fluid exuding.

  Therefore, the user first forms the minute opening in a state where the path of the moving member faces the instrument or the energy source, and the moving member is temporarily lifted (separated) from the surface of the living body while the supporting member remains as it is. The moving member is moved substantially parallel to the surface of the living body, lowered (approached) in a state where the suction chamber faces the formed minute opening to bring the moving member into close contact with the surface of the living body, and the suction means creates a negative pressure in the suction chamber. Then, the exuded body fluid is supplied to the measuring device or soaked into the test paper to enable measurement with a separately installed measuring device. As a result, it is possible to perform a series of operations from removing the microscopic opening to collecting the body fluid without removing the device, and without shifting the suction chamber that requires precise positioning with respect to the perforated microscopic opening. In addition to being able to be installed, the work can be performed in an airtight manner, so that it is possible to prevent infection and bacteria quality deterioration due to bacteria entering from the outside during the work. In addition, since the suction chamber and the path are formed separately, the suction chamber can be set to a minimum volume, and a necessary amount of body fluid can be collected in a short time with a weak suction force. Body fluid can be collected in a minimally invasive manner without damaging the device, and the body fluid collecting device can be miniaturized in combination with making the instrument or the energy source for forming the microscopic opening detachable. .

[Embodiment 1]
1 and 2 are perspective views showing the structure of body fluid sampling devices 1 and 11 according to an embodiment of the present invention. The body fluid sampling device 1 in FIG. 1 is generally formed in a cap shape, has a flange 21, has a bottom surface open, and a support member 20 that is a base member that is closely attached to the surface of a living body, and a minute opening is formed. A laser irradiation device 30 mounted on the cap-shaped top surface 22 of the support member 20, a moving member 50 housed in the support member 20, and the support member 50. In the member 20, it is comprised including the moving means 60 which moves to near and away from the living body surface, and approximately parallel to the living body surface, and a pump (not shown) which is a sucking means for sucking the exuded body fluid. The other bodily fluid collecting device 11 shown in FIG. 2 uses only the perforation device 40 which is an instrument for forming a microscopic opening instead of the laser irradiation device 30, and the remaining configuration is the same as that of the bodily fluid collecting device 1. It is the same.

  3 is a perspective view of the support member 20, FIG. 4 is a perspective view of the moving member 50, FIG. 5 is a perspective view showing a state in which they are assembled, and FIGS. It is sectional drawing for demonstrating operation | movement in the state attached. The support member 20 is generally formed in the cap shape, and includes a main body 25 having the flange 21, a side wall 23, and a top plate 24, and a plurality of positioning pins 26 erected on the top surface 22. And a magnet 27 attached to the back surface of the top plate 24. The body 25 is made of resin, and the side wall 23 has an outer diameter of about 3.5 cm. The top plate 24 has an opening 28 with a diameter of about 5 mm that is shifted from the center of the circle. Yes. When the laser irradiation device 30 is used, the opening 28 may be closed with a plate transparent to the laser light. The positioning pin 26 protrudes from the top surface 22 by about 1 mm. An adhesive tape for fixing the support member 20 to the biological surface is provided on the back surface of the flange 21. Furthermore, the side wall 23 is formed with an operation hole 29 having a shape as described later.

  On the other hand, the moving member 50 includes a resin-made disc-shaped main body 51 provided with the moving means 60 projecting radially outward from one side surface thereof. Since the main body 51 is housed in the support member 20, the main body 51 is formed to have a thickness of about 1 cm and a diameter of about 3 cm, and is shifted from the center corresponding to the opening 28 and has a circular shape of about 5 mm in diameter. Thus, a through hole 53 serving as a path through which an instrument for forming the minute opening or energy can pass is formed, and the minute opening is covered at a position shifted in the circumferential direction from the through hole 53. A suction chamber 54 is formed. When the laser irradiation device 30 is used, the through-hole 53 may also be closed with a plate transparent to laser light.

  Further, when the laser irradiation device 30 is used in the moving member 50, the exit of the through hole 53 that can be in close contact with the surface of the living body has high absorption characteristics of laser light such as carbon black, Absorber 55 made of a material capable of perforating the minute openings is adhered to living body surface (keratin layer) 2 by absorbing and generating heat. Here, when creating the microscopic aperture 3 on the biological surface 2 using the laser light, the microscopic aperture 3 is directly created using the laser light absorbed by the biological surface 2, and the absorber 55 as described above. It is considered that the minute opening 3 is created by the heat generation. When the absorber 55 is used, the absorption wavelength of the absorber 55 is largely shifted from the absorption wavelength of the living body, so that the surface of the living body is not damaged even if the laser beam is accidentally emitted, and safety is improved. Can do. Further, by using the absorber 55, the laser light source 31 can be arbitrarily selected, and the minute opening 3 having a required size and depth can be created with a minimum power. Can be reduced in size.

  The suction chamber 54 is formed in a narrow space recessed in a dome shape having a diameter of about 4 mm and a depth of about 2 mm. As shown in an enlarged view in FIG. 8, the top 54 a has a diameter and a height of about 2 mm. A cylindrical suction port 56 is provided, and the suction port 56 is connected to the moving means 60 formed of a pipe joint by a pipe line 57 having an outer diameter of 3 mm and an inner diameter of about 1 mm. The moving means 60 is connected to a tube to the pump, measuring instrument or sample collector. The main body 51 is made of a hard resin, but a part of the conduit 57 is a resin plug 58 that can be perforated by using a soft resin. In the suction port 56, there are provided a pair of electrodes 59 that react only with a specific component such as an enzyme electrode and cause a current to flow between the electrodes. The current generated between the electrodes 59 is installed outside. Can be detected by the signal detection device.

  The moving member 50 configured as described above is inserted into the operation hole 29 with the moving means 60 attached, and then the main body 51 is fitted into the support member 20 or the moving means 60 is inserted. After the main body 51 is fitted into the support member 20 in a state where it is removed, the moving means 60 is screwed into the main body 51 from the operation hole 29, so that the movement member 50 is within the support member 20 within the range of the operation hole 29. Both can be integrated with each other. The members 50 and 20 integrated in this way are referred to as a composite unit. Note that the center of the moving member 50 may be pivotally supported by the support member 20 with a pin so that the moving member 50 rotates smoothly, or the suction port may be provided on the side opposite to the moving means 60 for operation. Another moving means 60 connected to a dummy or another suction port not connected to 56 may be provided.

  On the other hand, the laser irradiation device 30 generally includes a laser light source 31 that is an energy source for forming the minute opening 3 on the living body surface 2, an optical system 32 that is appropriately provided, and a drive circuit 33 that drives the laser light source 31. Are housed in a housing 34 in which both ends of the cylinder are closed by end plates. A positioning recess 36 into which the positioning pin 26 is fitted is formed on the bottom surface 35 of the housing 34, and a magnet 37 that is attracted to the magnet 27 is provided. In addition, an opening 38 that faces the opening 28 is formed in the bottom surface 35. Similarly to the opening 28, the opening 38 may be closed by a member that is transparent to laser light.

  The laser light source 31 is a laser capable of pulse oscillation, and the drive circuit 33 oscillates the laser light source 31 in order to reduce the burden on the patient and performs high-power laser irradiation in a short time. Then, the minute opening 3 that does not reach the dermis layer 4 is formed on the living body surface 2. However, it is only necessary to obtain a sufficient output so that the microscopic aperture 3 can be formed on the living body surface 2, and it is not necessary to use a laser having a higher output than necessary. As long as the above conditions are satisfied, the laser used may be any type such as a multimode laser or a single mode laser. By using this laser light source 31, there is less pain and hygiene than a perforation apparatus 40 using a needle 41 described later.

  In the present embodiment, as shown in FIG. 9, the optical system 32 has a lens 32a for condensing the laser light from the laser light source 31 on the surface of the absorber 55 or the living body surface 2 and its optical axis 32b. Is provided with a rotating plate 32c which is an optical member for shifting the center of the moving member 50 from the center of the through hole 53. The rotating plate 32c made of flat glass or the like is provided to be inclined with respect to the optical axis 32b. The rotating plate 32c is rotated about the optical axis 32b, and the laser beam is emitted in pulses. Thus, a plurality of minute openings 3 can be formed on the living body surface 2. The positioning pin 26 and the positioning recess 36 or the magnets 27 and 37 that form a pair serving as a lock mechanism also have a function as a proximity switch. When the two are separated from each other, the drive circuit 33 operates as a laser light source. 31 is prohibited (locked).

  On the other hand, the punching device 40 generally includes a needle 41 which is an instrument for forming the microscopic opening 3 on the living body surface 2 and a drive mechanism 42 which can drive the needle 41 up and down. Both ends are housed in a housing 44 that is closed with an end plate. Similar to the case 34, a positioning recess 46 into which the positioning pin 26 is fitted is formed on the bottom surface 45 of the case 44, and a magnet 47 that is attracted to the magnet 27 is provided. In addition, an opening 48 is formed in the bottom surface 45 so as to face the opening 28 and in which the needle 41 appears and disappears. Also in this punching device 40, when the needle 41 is electrically driven up and down by the drive mechanism 42, the drive circuit responds to the output of the positioning pin 26 and the positioning recess 36 or the magnets 27 and 47, and supports it. When not mounted on the member 20, the needle 41 may be locked so as not to protrude.

  In the body fluid collection devices 1 and 11 configured as described above, a body fluid collection procedure will be described below. First, by pressing the bottom surface of the composite unit against the biological surface 2, the composite unit is fixed to the biological surface 2 with an adhesive tape attached to the back surface of the flange 21. The adhesive force of the adhesive tape may be an adhesive force that does not peel the composite unit from the biological surface 2 even if a certain amount of force is applied. When the adhesive strength is insufficient, the tape is fixed from above the flange 21 with a medical tape or the like, or the adhesive tape is not provided on the back surface of the flange 21 and is fixed only with the medical tape. For example, the mounting of the composite unit is optional.

  Next, the laser irradiation device 30 or the punching device 40 is mounted on the top surface 22 of the support member 20 so that the positioning pins 26 fit into the positioning recesses 36 and 46, and the magnets 37 and 47 and the magnet It is fixed by adsorption with 27. Accordingly, the openings 38 and 48 of the laser irradiation device 30 or the punching device 40 communicate with the opening 28 of the support member 20. Next, the moving means 60 is operated so as to be at the opening position of the operation hole 29, and the through hole 53 communicates with the openings 28; 38, 48.

  Here, as shown in FIG. 3, the operation hole 29 has a first drooping portion 29 a that extends in the axial direction in the cylindrical side wall 23 and extends horizontally from the upper end thereof. ) Moving part 29b extending in the direction, a second hanging part 29c hanging from the end of the moving part 29b (extending in the axial direction), and a horizontal (circumferential) direction extending from the lower end of the second hanging part 29c. And a lock portion 29d having a suction position to be described later.

  When the moving means 60 is moved to the second drooping portion 29c, the moving means 60 falls to the bottom of the second drooping portion 29c due to the weight of the moving member 50. In this state, the moving means 60 is locked. When it is moved in the circumferential direction up to 29d, the moving member 50 comes into close contact with the living body surface 2 and reaches the perforating position. In this way, a plurality of the micro openings 3 are drilled in the living body surface 2 in a state where the moving member 50 is locked.

  Subsequently, when the moving means 60 is lifted, the moving member 50 is separated from the living body surface 2, and when the moving means 60 is moved in the circumferential direction, the moving means 60 passes through the moving portion 29b. When moving to the first drooping portion 29a and descending, the moving member 50 comes into close contact with the living body surface 2 again, and as shown in FIG. 7, it becomes a suction position where the suction chamber 54 covers the minute opening 3. In this way, the moving member 50 can be moved without damaging the biological surface 2. In addition, by applying a lubricant to the gap between the outer peripheral surface of the moving member 50 and the inner peripheral surface of the support member 20, the sliding of the movement is improved, and the sealing performance is improved by filling the gap. it can.

  Thereafter, when a tube to the pump, measuring device, sample collection device or the like is connected to the moving means 60 serving as a pipe joint, the body fluid is prevented from being lifted from the living body surface 2 by the negative pressure. The glucose concentration is measured by the electrode 59 and the like. At this time, due to the negative pressure in the suction chamber 54, the living body surface 2 rises slightly as shown in FIG. 8, and the suction port 56 and the minute opening 3 provided in the top 54a of the suction chamber 54 formed in a dome shape. Thus, the body fluid can be efficiently sucked into the suction port 56. After sucking a predetermined amount of body fluid, the pump is automatically or manually stopped. Note that after the micro-opening 3 is drilled, the laser irradiation device 30 and the drilling device 40 that are only attracted to the support member 20 by the magnets 37, 47; 27 may be removed.

  In addition to the equipment connected to the moving means 60, separately, an injection needle and a sensor are inserted into the stopper 58 in a state filled with body fluid from the suction chamber 54 to the suction port 56 and the conduit 57. Body fluids can be collected. Thereby, it can utilize also for the detection apparatus which cannot put the extract | collected bodily fluid near a patient, or the detection apparatus which cannot be integrated in a composite unit. After the body fluid is collected by the above operation, the composite unit is removed from the biological surface 2 and appropriately disposed.

  As described above, the body fluid sampling devices 1 and 11 according to the present invention form the minute opening 3 in a state where the moving member 50 is located at the perforated position, and operate the moving means 60 while the support member 20 remains as it is. The moving member 50 is once lifted (separated) from the living body surface 2 and moved substantially parallel to the living body surface 2, and the moving member 50 is lowered (closed) with the suction chamber 54 facing the formed minute opening 3. 50 is brought into close contact with the living body surface 2, and the suction chamber 54 is made negative pressure by suction means such as a pump, and the exuded body fluid is supplied to the measuring device, or is soaked into the test paper and separately installed. Can be performed in a series of operations without removing the device from the formation of the microscopic aperture 3 to the collection of the body fluid, and precise positioning is required for the microscopic aperture 3 that has been perforated. Slipping suction chamber 54 It is possible to Ku installation, since perform the work in an air-tight, it is possible to prevent quality deterioration of the infection and the body fluid with bacteria or the like intruding from the outside during operation. Further, since the suction chamber 54 and the through-hole 53 are formed separately, the suction chamber 54 can be made a minimum volume, and a necessary amount of body fluid can be collected in a short time with a weak suction force. It is possible to collect body fluid in a minimally invasive manner without causing pain and burden, and to make the laser irradiation device 30 and the perforation device 40 for forming the minute opening 3 freely detachable, and to collect the body fluid 1 and 11 can be reduced in size.

  Further, when the laser light source 31 is used as an energy source for forming the minute opening 3, the optical axis 32 b is shifted from the center of the through hole 53 between the laser light source 31 and the through hole 53 of the moving member 50. The rotating plate 32c is interposed, and the rotating plate 32c is rotated around the optical axis 32b by the rotating means to form a plurality of the micro openings 3, so that more body fluid can be collected in the same time, or the same amount Body fluid can be collected in a shorter time.

  Furthermore, since the laser irradiation device 30 and the perforation device 40 can be removed from the support member 20, it is possible to eliminate complications when sampling over a long period of time, and the laser can be used by a plurality of patients. The irradiation device 30 and the punching device 40 can be shared. And even if it can be removed in this way, a positioning pin 26 and positioning recesses 36 and 46 for mutual positioning are provided between them, and in the case of the laser irradiation device 30, the drive circuit 33 is positioned. If not performed, oscillation of the laser light source 31 is prohibited (locked), so that leakage of laser light can be prevented and safety can be improved.

[Embodiment 2]
FIG. 10 is a perspective view showing the structure of the moving member 50 ′ in the body fluid sampling device according to another embodiment of the present invention. The moving member 50 ′ is similar to the moving member 50 shown in FIG. 4 described above, and corresponding portions are denoted by the same reference numerals and description thereof is omitted. It should be noted that in the moving member 50 ′, a plurality of suction chambers 54 ′ are formed in the main body 51 ′. Although all the suction chambers 54 ′ communicate with the moving means 60, which is a pipe joint, in the suction chamber that does not face the minute opening 3, body fluid does not exude even if suction is performed. Absent. The corresponding support member is formed with a plurality of the second hanging parts 29c and a plurality of lock parts 29d connected to the second hanging parts 29c from the long moving part 29b.

  With this configuration, when it is necessary to collect body fluid from the same patient every predetermined time, the suction chamber 54 can be renewed every time, and precise and hygienic measurement can be performed.

[Embodiment 3]
11 to 13 are perspective views showing a structure of a composite unit in a body fluid sampling device according to still another embodiment of the present invention, FIG. 11 is a perspective view of a support member 20 '', and FIG. FIG. 13 is a perspective view showing a state in which they are assembled, and is similar to FIGS. 3 to 5 described above. It should be noted that while the moving members 50 and 50 ′ were rotationally moved in the above-described composite unit, the moving member 50 ″ of the composite unit moved linearly. For this reason, the main body 51 '' of the moving member 50 '' is formed in a rectangular plate shape, and the support member 20 '' is also formed in a box shape correspondingly. As described above, the shapes of the moving members 50, 50 ′, 50 ″ may be appropriately selected in accordance with the size and number of the suction chambers 54 to be formed. In addition to the manual type, the mechanical type using the elasticity of a spring or the electric type using the rotation of a motor may be used.

It is a perspective view which shows the structure of the bodily fluid sampling device which concerns on one Embodiment of this invention. It is a perspective view which shows the structure of the bodily fluid sampling device which concerns on one Embodiment of this invention. It is a perspective view of the support member in the body fluid sampling device. It is a perspective view of the moving member in the body fluid sampling device. It is a perspective view which shows the state which assembled | attached the member of FIG. 3 and FIG. It is sectional drawing for demonstrating the operation | movement in the state of the said FIG. It is sectional drawing for demonstrating the operation | movement in the state of the said FIG. It is sectional drawing which expands and shows the said moving member. It is sectional drawing which shows typically the structure of the laser irradiation apparatus used for the bodily fluid collection | recovery apparatus shown in FIG. It is a perspective view which shows the structure of the moving member in the bodily fluid sampling device which concerns on other forms of implementation of this invention. It is a perspective view of the supporting member in the bodily fluid sampling device concerning the further other form of implementation of the present invention. It is a perspective view of the moving member in the bodily fluid sampling device concerning the further other form of implementation of the present invention. It is a perspective view which shows the state which assembled | attached the member of FIG. 11 and FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1,11 Body fluid sampling device 2 Living body surface 3 Micro opening 4 Dermal layer 20, 20 '' Support member 21 Flange 22 Top surface 23 Side wall 24 Top plate 25, 51, 51 'Main body 26 Positioning pins 27, 37, 47 Magnet 28, 38, 48 Opening 29 Operation hole 30 Laser irradiation device 31 Laser light source 32 Optical system 32a Lens 32c Rotating plate 33 Drive circuit 34, 44 Housing 36, 46 Positioning recess 40 Punch device 41 Needle 42 Drive mechanism 50, 50 ', 50 '' Moving member 53 Through hole 54, 54 'Suction chamber 55 Absorber 56 Suction port 57 Pipe line 58 Plug 59 Electrode 60 Moving means

Claims (7)

In a bodily fluid collection device that forms a microscopic opening on the surface of a living body and collects bodily fluids,
An instrument or energy source for forming the micro-aperture;
A support member on which the bottom surface is opened and is closely attached to the surface of the living body, and the instrument or energy source is mounted on the top surface;
A movement accommodated in the support member, and a path through which an instrument or energy for forming the micro-openings can pass and a suction chamber covering the micro-openings are installed in parallel with the surface of the living body. Members,
A suction means connected to the suction chamber for sucking a body fluid;
A bodily fluid sampling apparatus comprising: a moving means for moving the moving member toward and away from the surface of the living body and moving substantially parallel to the surface of the living body within the support member.   The body fluid sampling device according to claim 1, wherein a laser light source is used as an energy source for forming the minute opening.   The body fluid sampling device according to claim 2, wherein an absorber that generates heat by absorbing the laser light is provided at an end of the path of the moving member.   An optical member for shifting the optical path from the center of the path is provided between the laser light source and the path of the moving member, and a rotating means for rotating the optical member about the incident optical axis as a rotation center is further provided. The body fluid collecting device according to claim 2, further comprising a body fluid collecting device.   The laser light source is removable from the support member, and positioning means for mutual positioning is provided between the laser light source and the support member. On the laser light source side, if positioning is not performed, The body fluid sampling device according to any one of claims 2 to 4, further comprising a lock mechanism that prohibits the emission of laser light.   The body fluid sampling device according to any one of claims 1 to 5, wherein the suction chamber is formed in a dome shape, and a suction port to the suction means is provided at a top portion thereof.   The bodily fluid collection device according to any one of claims 1 to 6, wherein a resin stopper capable of being pierced is installed in a part of a pipe line from the suction chamber to the suction means.

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