JP2009196958A - Soft capsule highly containing powder and its manufacturing method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To solve such a problem that when powder is contained 60% or more as a content, a soft capsule form has not been produced by a conventional manufacturing method. <P>SOLUTION: The soft capsule highly containing powder is the one where the content of the soft capsule is composed of a powder and an oil and fat-based substance, and the weight of the powder is 60-99.9% against the total weight of the content. For example, the soft capsule can be manufactured by utilizing a rotary method equipped with rotary molds 8, supplying the powder in a solid form 3' into a pocket 9 of the one mold 8 by pushing it onto a film sheet 5' from above before the pockets 9 are faced each other, and filling and supplying the oil and fat-based substance 4 between the two film sheets 5', 5' within the faced pockets 9, 9. Because the powder in a solid form 3' is covered with the oil and fat-based substance 4, the content of the soft capsule can be similarly handled as the content for the conventional soft capsule. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to capsules used in pharmaceuticals, foods, and the like, and more particularly to a soft capsule of a type in which a capsule content containing a high amount of powder in an oily base is encapsulated by a film.

Capsules are broadly divided into hard capsules and soft capsules, and any type has been used. However, as the name implies, soft capsules are flexible and difficult to break, and they absorb moisture. It is widely used because it can be stably protected from chemical changes such as oxidation.
However, when manufacturing a soft capsule, the coating sheet is usually removed by using the rotary method in which the mold is rotated and using the viscosity of the contents filled between the two coating sheets. Three-dimensionally molded along the pocket shape by spreading it.
Therefore, the content of the soft capsule is required to have a viscosity that can spread the film sheet as evenly as possible.
Therefore, when the substance to be encapsulated is in powder form, it is used as a suspension suspended in a suitable oil-based base material, and the relative weight of the powder in the total content is considerably suppressed. It was.

For the above reasons, when it is desired to increase the amount of the powder, it is usually provided as a hard capsule or a tablet obtained by pressing and solidifying the powder.
However, in the case of hard capsules, the contents are easily subjected to chemical changes such as moisture absorption and oxidation through a gap formed between the cap and the body, and are difficult to take orally.
In the case of tablets, it is indispensable to add a certain amount of excipient to solidify the powder, and cracks and corners are relatively easy to occur. Moreover, since the surface of the contents is exposed, it is not only susceptible to various chemical changes such as moisture absorption and oxidation, but the bitterness and odor unpleasantness derived from the contents is not alleviated when taken orally.

  In order to eliminate the above disadvantages, film-coated tablets and sugar-coated tablets covering the surface of various hard capsules and tablets have been proposed, but special equipment and materials necessary for coating, relatively advanced Coating technology and tablet processing technology are burdened and increase manufacturing costs.

Registered Utility Model No. 3131717 JP 2004-250336 A

In view of the above, an object is to provide a new and useful form of soft capsules in which the relative content of powder can be dramatically increased as compared with the prior art.
It is another object of the present invention to provide a method for producing the above-described soft capsule.

As a result of earnest research, the present inventors have
(1) What can be the contents of a soft capsule is not limited as long as the two coating sheets are spread outwardly in the pocket of the mold, and can completely enter the expanded space. Even if there is a core, if it is completely covered with an oil-based substrate, it can be handled as the contents of a soft capsule as before,
(2) The pressure required for solidifying the powder is sufficient by pressure molding, and it is not necessary to add excipients,
I found a soft capsule as a content of what was solidified powder and covered with an oil-based base material,
The inventors have succeeded in dramatically increasing the content of powder as an active ingredient, and have completed the present invention shown below.

The invention of claim 1 is characterized in that the content of the soft capsule is composed of a powder and an oil-based substrate, and the weight of the powder is 60 to 99.9% with respect to the total weight of the content. Soft capsule.
The invention according to claim 2 is the soft powder high-content capsule according to claim 1, characterized in that the content of the soft capsule does not contain a viscosity modifier that does not become an active ingredient.
Invention of Claim 3 is comprised by the layer containing the lipid which becomes solid when the part which contacts the inside of a capsule membrane | film | coat is 40 degrees C or less, The powder height described in Claim 1 or 2 characterized by the above-mentioned Contains soft capsules.
The invention according to claim 4 is characterized in that the capsule film is formed by joining two film sheets, and the joined part does not protrude, and the soft capsule with high powder content according to any one of claims 1 to 3 It is.

The invention of claim 5 is a method for producing the powder-rich soft capsule according to any one of claims 1 to 4 by sealing and punching two coating sheets and filling the contents, It is a method for producing a soft capsule containing a high amount of powder, characterized in that it is composed of a solid material obtained by pressure-molding a powder and an oil-based base material covering the solid material.
The invention of claim 6 utilizes a rotary method in which the mold is a rotary type, and pushes and supplies the powder solids into the pocket of one mold from the top of the coating sheet before the pocket directly faces, 6. The method for producing a soft capsule with a high content of powder according to claim 5, wherein filling and feeding are performed between two coated sheets in a facing pocket.

In the soft capsule of the present invention, the powder content is dramatically increased as compared with the conventional soft capsule.
And the above-mentioned soft capsule can be manufactured using the rotary type soft capsule manufacturing apparatus conventionally used conventionally.

Hereinafter, the soft capsules with high powder content of the present invention will be described in detail based on the embodiments shown in the accompanying drawings.
(Soft capsule shape and structure)
The shape is not particularly limited, but when it is manufactured using a rotary soft capsule manufacturing apparatus, it depends on the shape of a mold pocket provided therein.
1 and 2 are cross-sectional views of a soft capsule 1 according to an embodiment of the present invention. The soft capsule 1 includes a content 2 and a capsule film 5 covering the content 2. The capsule coating 5 is formed into a three-dimensional shape by joining and punching two coating sheets S described later, and a joining portion 6 having a slightly recessed boundary is formed.
The film of the dried capsule is thickest in the vicinity of the joint portion 6 and is thinnest in the middle portion, but most of the thickness dimension (d1) of any portion is in the range of 0.05 to 5.00 mm. It is settled.

(Structure of contents)
The contents 2 are composed of a powder 3 and an oil base 4.
As shown in FIG. 1, the oil base 4 is relatively preferentially present on the capsule film 5 side, and the powder 3 is relatively preferentially present on the center side, as shown in FIG. In some cases, a layer of the oil-based base material 4 is formed on the side in contact with the capsule film 5.
The material of the powder 3 is not limited to those conventionally used as the contents of soft capsules, and can be used in materials that have conventionally been selected in the form of hard capsules or tablets.

  Moreover, in the case of the fat-type base material 4 containing the lipid which becomes a solid at 40 ° C. or lower, it can be used as long as it is heated at the time of filling and supplying a liquid having an appropriate fluidity. When the above-mentioned oil is used, it is as shown in FIG. On the other hand, in the case of using an oil-based base material containing a lipid that becomes solid when the temperature is 40 ° C. or lower, the soft capsule is solidified by a temperature drop after the production of the soft capsule. Therefore, as shown in FIG. Immediately below the capsule film 5 is a solid lipid layer, that is, a hydrophobic layer 4 ′. Therefore, by using fat, it is possible to effectively prevent the moisture of the capsule film 5 from moving into the capsule, so that it is particularly useful when the powder has high water absorption.

  The weight ratio of the powder 3 and the fat-based base material 4 can be set in a range of 99.9 to 60: 1 to 40, but the lower limit value of the powder 3 is to clarify the distinction from the conventional soft capsules. The amount of soft capsules that have been provided so far cannot be included.

As a material of the capsule film 5, glycerin, PVA or the like is added to gelatin as a plasticizer, but is not limited thereto. Alginic acid, HMC (hydroxymethylcellulose), HPMC (hydroxypropylmethylcellulose), gellan gum, curdlan, etc., and these oxidized and alkalized thickening polysaccharides can also be used.
Furthermore, it is also possible to include coloring agents such as natural pigments, food pigments, chemically synthesized pigments, titanium dioxide, and Ca compounds as film components.

(Manufacturing equipment)
A rotary soft capsule manufacturing apparatus conventionally used for soft capsule manufacturing can be used.
FIG. 3 is a schematic view of an example of the manufacturing apparatus 7. A plurality of pockets 9, 9 defining a capsule shape are formed on the outer peripheral surfaces of a pair of molds 8, 8 that are arranged opposite to each other and rotate in reverse. . Reference numeral 10 denotes a segment. The supply path 11 extends vertically through the segment 10, and its lower end faces between the pair of molds 8 and 8. Further, the segment 10 is provided with a heater 12 for heating.
Reference numeral 13 denotes a liquid supply path for the oil base 4, one end of which is connected to a liquid tank (not shown) and the other end is connected to the supply path 11. A supply pump 14 is provided in the middle of the liquid supply path 13, and the supply amount of the liquid is determined by the operating state of the supply pump 14.

In order to successfully manufacture the soft capsule 1 of the present invention, the manufacturing apparatus 7 having the above structure is provided with the following.
Reference numeral 15 denotes a conveyance path, and the conveyance path 15 is constituted by a vibration feeder. The conveyance path 15 is inclined and its lower end is horizontal. A drop hole 16 is formed in the horizontal portion. The drop hole 16 is designed more fully than the powder solid 3 '. Below the drop hole 16, the uppermost pocket 9 of the right mold 8 faces.
Reference numeral 17 denotes a pushing instrument. A shaft 18 of the pushing instrument 17 can be moved back and forth in the vertical direction. A contact piece 19 is attached to the lower end of the shaft 18. It is designed to be sufficiently smaller than the drop hole 16 of the conveyance path 15. The pushing device 17 is disposed on the right side of the segment 10, and when the shaft 18 is retracted, the contact piece 19 is waiting on the drop hole 16 of the conveyance path 15, and when the shaft 18 is advanced, the contact piece 19 is in contact. The piece 19 penetrates the drop hole 16 of the conveyance path 15 and enters the pocket 9 of the mold 8.

(Manufacturing method using manufacturing apparatus 7)
As shown in FIG. 3, two coating sheets 5 ′ and 5 ′ are supplied onto rotating molds 8 and 8 from the upper left and right sides.
At the same time, the powder solid 3 'is also sequentially conveyed on the conveyance path 15. And as shown in FIG. 4 (1), it falls on the film sheet 5 'on the right side from the dropping hole 16. FIG. Further, as shown in FIG. 4 (2), when the shaft 18 of the pushing instrument 17 is advanced, the powder solid material 3 ′ is pushed by the abutting piece 19 into the pocket 9 of the mold 8. 'Push from above. Thereafter, the right coating sheet 5 ′ and the left coating sheet 5 ′ are heated appropriately with respect to the segment 10, and the two coating sheets 5 ′ and 5 ′ are moved downward by rotating the molds 8 and 8. Then, the pockets 9 and 9 are brought into contact with each other at the directly facing positions, joined and punched by the action of heat and pressure. At the same time, the oil base 4 is filled and supplied at a predetermined timing by the operation of the supply pump 14 between the two coating sheets 5 ′ and 5 ′, and the coating sheets 5 ′ and 5 ′ are spread outward. As a result, a soft capsule having the shape of the pockets 9 and 9 is obtained. That is, it becomes a soft capsule in which the oil base 4 is present between the coating sheet 5 ′ and the powder solid 3 ′.

  Moreover, since the oil-based base material 4 exists between the coating sheets 5 ′ and 5 ′ and the powder solid 3 ′, the obtained soft capsule 1 has a slightly joined portion 6 as shown in FIG. Even if it dents, it does not protrude into an unpleasant convex shape.

[Sample preparation]
(Sample 1)
The coating solution was prepared by blending gelatin (coating substrate component): 100 parts by weight and water: 90 parts by weight and stirring for 60 minutes while vacuum degassing under heating at 65 ° C. In particular, no plasticizer was used. The powdered solid was prepared by blending chondroitin sulfate and blueberry powder in a weight ratio of 20: 1, mixing for 60 minutes in a V-type mixer, and then adding an ellipse having a major axis of 12 × minor axis of 6 × thickness of 3.5 mm. A pressure-molded product was prepared.
After completing the preparation of the coating liquid and the powdered solid, soft capsules were manufactured using the manufacturing apparatus 7 shown in FIG. MCT was used as the oil-based substrate, and 2 parts by weight was filled with respect to 100 parts by weight of the powder solid.
The size of the obtained soft capsule was 13 × 7 mm, the film weight immediately after molding was 130 mg, the content weight was 200 mg, and the total capsule weight was 330 mg.

(Sample 2)
The coating solution is blended at a ratio of gelatin (coating substrate component): 90 parts by weight, pullulan (coating substrate component): 15 parts by weight, water: 90 parts by weight, while vacuum degassing under heating at 65 ° C. What was prepared by stirring for 60 minutes was prepared. In particular, no plasticizer was used. The powdered solid was prepared by blending chitosan and blueberry powder in a weight ratio of 20: 3, mixing for 60 minutes in a V-type mixer, and adding to an ellipse having a major axis of 12 × minor axis of 6 × thickness of 3.5 mm. A pressure-molded product was prepared.
After the preparation of the coating solution and contents, soft capsules were manufactured using the manufacturing apparatus 7 shown in FIG. MCT was used as the fat-and-oil base, and 5 parts by weight was filled with respect to 100 parts by weight of the powder solid.
The size of the obtained soft capsule was 13 × 7 mm, the film weight immediately after molding was 160 mg, the content weight was 250 mg, and the total capsule weight was 410 mg.

(Sample 3)
The coating solution is blended at a ratio of gelatin (coating substrate component): 100 parts by weight, glycerin (plasticizer): 30 parts by weight, water: 90 parts by weight, and heated for 60 minutes while being vacuum degassed under heating at 65 ° C. What was prepared by stirring was prepared. The powdered solid was prepared by blending chondroitin sulfate and blueberry powder in a weight ratio of 20: 1 and mixing for 60 minutes in a V-type mixer, then into an ellipse having a major axis of 12 × minor axis of 6 × thickness of 3.5 mm. A pressure-molded product was prepared.
After the preparation of the coating solution and contents, soft capsules were manufactured using the manufacturing apparatus 7 shown in FIG. MCT was used as the oil-based substrate, and 10 parts by weight was filled with respect to 100 parts by weight of the powder solid.
The size of the obtained soft capsule was 13 × 7 mm, the film weight immediately after molding was 130 mg, the content weight was 220 mg, and the total capsule weight was 350 mg.

(Control 1)
The coating solution is blended at a ratio of gelatin (coating substrate component): 100 parts by weight, glycerin (plasticizer): 30 parts by weight, water: 90 parts by weight, and heated for 60 minutes while being vacuum degassed under heating at 65 ° C. What was prepared by stirring was prepared. The contents were prepared by blending chondroitin sulfate, blueberry powder, MCT and glycerin fatty acid ester in a weight ratio of 18: 2: 10: 5.
After the preparation of the film and contents, soft capsules were manufactured using a conventional rotary soft capsule manufacturing apparatus.
The size of the soft capsule was 13 × 7 mm, the film weight immediately after filling was 110 mg, the content weight was 200 mg, and the total capsule weight was 310 mg.

(Control product 2)
The coating solution is blended at a ratio of gelatin (coating substrate component): 100 parts by weight, glycerin (plasticizer): 30 parts by weight, water: 90 parts by weight, and heated for 60 minutes while being vacuum degassed under heating at 65 ° C. What was prepared by stirring was prepared. The contents were prepared by mixing chondroitin sulfate, blueberry powder, MCT and glycerin fatty acid ester in a weight ratio of 18: 2: 4: 2.
After the preparation of the film and contents, we tried to manufacture soft capsules using a conventional rotary soft capsule manufacturing device. However, the fluidity of the inner solution required in a filling pump called a medicine pump is known. Therefore, the inner solution pushed out from the pump was clogged in the resin tube, and the contents could not be filled.
The size of the soft capsule was 13 × 7 mm, the film weight immediately after filling was 110 mg, the content weight was 200 mg, and the total capsule weight was assumed to be around 310 mg.

Each of the obtained specimens and the capsules of the control product 1 were similarly dried until the moisture content of the capsule film was 10 ± 1% to obtain a finished product.
The weight ratio and yield of the powder and oil of the contents of the capsules of the obtained specimens and the control product 1 were as follows.

[Evaluation]
<Capsule high temperature test>
In order to confirm the occurrence of leakage and adhesion of the solution in the capsule by storing it at a high temperature, it was tested according to the following procedure.
(1) Twenty capsules were placed in a No. 6 glass bottle, sealed, and stored at + 40 ° C.
(2) After 14 days (2 W), 28 days (4 W), 56 days (8 W), and 112 days (16 W), the states were observed.
The results were as follows.

[Evaluation]
<Capsule content liquid leakage comparison test-heat and cold resistance test>
In order to confirm the occurrence of leakage of the solution in the capsule by repeating the expansion and contraction of the capsule film due to a rapid temperature change by storing in a high temperature or cold place, the following method was used for testing.
(1) Samples of 20 capsules were placed in a No. 6 glass bottle, sealed, and stored at −20 ° C. for 24 hours and then at + 40 ° C. for 24 hours.
(2) The above was made into 1 cycle, this was implemented 3 cycles, and the leakage of the fat-type base material which is a content liquid was observed.
The results were as follows.

［評価］

[Evaluation]

<Capsule disintegration test>
In order to confirm the disintegration property of the capsule of the present invention, a disintegration test was conducted by the following method.
Six capsules of the present invention (samples 1 to 6) were put in a test machine, immersed in purified water maintained at 37 ° C., moved up and down, and the time until the capsule opened was measured. The content of this test conforms to the Japanese Pharmacopoeia (15th revision) disintegration test method. The measurement was performed 6 times, 6 capsules at a time, and the average value was obtained. The results are shown in Table 4. As a control product, the conventional gelatin capsules were similarly measured for the opening time, and the results are also shown in Table 4.
The results were as follows.

<Capsule impact test>
In order to confirm the occurrence of leakage of the content liquid by repeatedly applying vibration and shock to the capsule, the following procedure was used for testing.
(1) Each specimen was placed in a No. 6 glass bottle with 10 capsules and dried under reduced pressure for 24 hours in a desiccator to prepare the dried state of the capsules.
(2) After drying, the No. 6 glass bottle was sealed and oscillated for 120 seconds at a cycle of 5 times / second with a vertical amplitude of 10 cm.
(3) The above was made into 1 cycle, this was implemented 5 cycles, and the leakage of the content liquid was observed.
The results were as follows.

From the results of the above-described capsule stability test, capsule severe test, and capsule disintegration test, the soft capsule of the present invention has a high powder content of 60% or more with respect to the oil content. It was demonstrated that there was no particular effect on yield and disintegration.
Furthermore, when the oil content in the contents is low, the plasticizer in the film can be reduced from the usual amount, and the strength of the soft capsule film can be set low. The reason for this is that the content is so solid that it is difficult for the content to expand or contract even if the temperature changes, preventing cracking due to liquid leakage from the film adhesive or impact from the external pressure of the capsule. be able to. As a result, it has been proved that the adhesion of the capsule film, which is a drawback of the soft capsule which has been a problem in the past, can be improved.

[Sample preparation]
(Sample 4)
The coating solution is blended at a ratio of gelatin (coating substrate component): 100 parts by weight, glycerin (plasticizer): 30 parts by weight, water: 90 parts by weight, and heated for 60 minutes while being vacuum degassed under heating at 65 ° C. What was prepared by stirring was prepared. The powder solid was prepared by blending dry vitamin A powder (containing 6% vitamin A fatty acid ester), maltitol and sucrose fatty acid ester in a weight ratio of 1: 20: 2, and mixing for 60 minutes in a V-type mixer. Then, what was press-molded into an ellipse having a major axis of 12 × minor axis of 6 × thickness of 3.5 mm was prepared.
After the preparation of the coating solution and contents, soft capsules were manufactured using the manufacturing apparatus 7 shown in FIG. MCT was used as the oil-based substrate, and 2 parts by weight was filled with respect to 100 parts by weight of the powder solid.
The size of the obtained soft capsule was 13 × 7 mm, the film weight immediately after molding was 130 mg, the content weight was 210 mg, and the total capsule weight was 340 mg.

(Sample 5)
The coating solution is blended at a ratio of gelatin (coating substrate component): 100 parts by weight, glycerin (plasticizer): 30 parts by weight, water: 90 parts by weight, and heated for 60 minutes while being vacuum degassed under heating at 65 ° C. What was prepared by stirring was prepared. The powder solid was prepared by blending dry vitamin A powder (containing 6% vitamin A fatty acid ester), maltitol and sucrose fatty acid ester in a weight ratio of 1: 20: 2, and mixing for 60 minutes in a V-type mixer. Thereafter, an ellipse having a major axis of 12 × minor axis of 6 × thickness of 3.5 mm was prepared by pressure molding.
After the preparation of the coating solution and contents, soft capsules were manufactured using the manufacturing apparatus 7 shown in FIG. Beeswax was used as the fat and oil base, and 10 parts by weight was filled per 100 parts by weight of the powdered solid.
The size of the obtained soft capsule was 13 × 7 mm, the coating weight immediately after molding was 130 mg, the content weight was 218 mg, and the total capsule weight was 348 mg.

(Control 3)
Dry vitamin A powder (containing 6% vitamin A fatty acid ester), maltitol and sucrose fatty acid ester are mixed at a weight ratio of 1: 20: 2, mixed for 60 minutes in a V-type mixer, and then vertically An uncoated tablet was manufactured by press-molding into a circle having 8 × width 8 × height 4 mm and a total weight of 200 mg.
(Control 4)
Dry vitamin A powder (containing 6% vitamin A fatty acid ester), maltitol and sucrose fatty acid ester are mixed at a weight ratio of 1: 20: 2, mixed for 60 minutes in a V-type mixer, and then vertically It was press-molded into a circle of 8 × 8 × 4 mm in height and a total weight of 200 mg to obtain a powder solid.
After uniformly coating 3 mg of shellac on the surface of the solid material, the composition of granulated sugar: eggshell Ca: HPMC: Ca carbonate: gum arabic: gelatin is prepared in a ratio of 70: 20: 4: 4: 1: 1 by a conventional method. A sugar-coated layer was formed to produce a sugar-coated tablet.
The size of the resulting sugar-coated tablets was 9.5 × 6.5 mm, and the total weight was 400 mg.

[Evaluation]
<Oxidation comparison test of contents>
In order to confirm the residual amount of the vitamin A fatty acid ester as the contents of the specimen 4, the specimen 5, the control product 3, and the control product 4 stored at room temperature, the test was performed according to the following procedure. Vitamin A fatty acid esters are easy to oxidize in the air, so they were used as indicators of the degree of oxidation of the contents.
(1) Each specimen was placed in a No. 6 glass bottle with 20 capsules, sealed, shielded with aluminum foil so as not to be affected by light, and stored at room temperature.
(2) After 14 days (2 W), 28 days (4 W), 56 days (8 W), and 112 days (16 W), retanol extracted from the content of hexane was extracted using an ultraviolet-visible spectrophotometer. Thus, the residual amount of retinal was measured.
The results were as follows.

  From the results of the oxidation comparison test of the above contents, the soft capsule of the present invention has an antioxidant effect due to the presence of the oil layer inside the capsule film, and when the oil amount is relatively large, the antioxidant effect Has been demonstrated to have a long and stable persistence, and when a solid lipid layer is formed inside the film, further antioxidant effect has been demonstrated.

In the case of health foods, it is required that the amount of active ingredients per unit volume be as large as possible while simultaneously protecting the active ingredients from oxidation. This is because if the amount of powder that can be encapsulated in one capsule increases, the number of capsules taken orally can be reduced, and it can be safely provided to consumers.
On the other hand, the soft capsule of the present invention can dramatically increase the amount of powder that can be encapsulated in one capsule as compared with the conventional capsule, and the powder is an oil-based substrate layer, usually an oil layer, inside the capsule film. It is difficult to oxidize air because it is surrounded by. Furthermore, since the oil-based base material is contained inside the capsule film, when the powder is fat-soluble, the absorbability in the body can be improved compared to tablets and sugar-coated tablets.
Therefore, the soft capsule of the present invention can contribute particularly to an increase in demand for health foods.

It is sectional drawing of the 1st soft capsule which concerns on embodiment of this invention. It is sectional drawing of the 2nd soft capsule which concerns on embodiment of this invention. It is the schematic of the manufacturing apparatus of the soft capsule which concerns on embodiment of this invention. It is explanatory drawing of the one part process by the manufacturing apparatus of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Soft capsule 2 Contents 3 Powder 3 'Powder solid body 4 Oil base material 4' Hydrophobic layer 5 Capsule film 5 'Film sheet 6 Joining part 7 Soft capsule manufacturing apparatus 8 Mold 9 Pocket 10 Segment 11 Supply path 12 Heater 13 Liquid supply path 14 Supply pump 15 Transport path 16 Drop hole 17 Pushing tool 18 Shaft 19 Contact piece

Claims (6)

  A soft capsule containing a high amount of powder, characterized in that the content of the soft capsule is composed of a powder and an oil-based substrate, and the weight of the powder is 60 to 99.9% of the total weight of the content.   The soft capsule content-enriched soft capsule according to claim 1, wherein the content of the soft capsule does not contain a viscosity modifier that does not become an active ingredient.   3. The soft powder-rich capsule according to claim 1, wherein the capsule skin is composed of a layer containing a lipid that becomes a solid when the portion in contact with the inside of the capsule film is 40 ° C. or lower.   The capsule high-content soft capsule according to any one of claims 1 to 3, wherein a capsule film is formed by bonding two film sheets, and a bonded part does not protrude.   A method for producing a soft capsule with high powder content according to any one of claims 1 to 4 by sealing and punching two film sheets and filling the contents, wherein the powder is pressure-molded as the contents What is comprised of the solid substance which becomes and the fat-type base material which covers it is used, The manufacturing method of the powder high content soft capsule characterized by the above-mentioned.   Using a rotary method where the mold is rotating, powder solids are pushed into the pocket of one mold from the top of the film sheet before the pocket is directly facing the pocket, and the powder in the pocket facing the oil-based substrate is then fed. 6. The method for producing a soft capsule with high powder content according to claim 5, wherein filling and feeding are performed between the two coated sheets.

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