JP2009180545A - Biosensor correction chip and biosensor system - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biosensor correction chip capable of automatically and certainly discriminating whether the chip inserted in a measuring instrument is a biosensor chip or the biosensor correction chip, and a biosensor system. <P>SOLUTION: The voltage level appearing in the first terminal (d) of a plurality of the terminals of a connector electrode 6 when a connection electrode 16 is inserted in the insertion part 5 of the measuring instrument 2 to be connected to the connector electrode 6 is differentiated from that in the case where the biosensor chip 1 is inserted to discriminate between the biosensor chip 1 and the biosensor correction chip 14. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a plurality of connection terminals for digital signal output that can be inserted into an insertion part of a measuring instrument for measuring a biosensor chip and connectable to a connector electrode provided in the insertion part of the measuring instrument, and a biosensor The present invention relates to a biosensor correction chip and a biosensor system comprising storage means for storing different data for each chip production lot.

  Conventionally, research on bioelectronics in which biological functions are applied to the electronics field has been progressing. The biosensor chip in the bioelectronics field is a device that uses an excellent molecular identification function of a living body, and is promising in the future as it can measure a chemical substance quickly and easily.

  Such a biosensor chip is applied as a sensor for measuring a small amount of sample. For example, the biosensor chip is used for a home health check (self-care) for self-management and prevention of diabetes by measuring a blood glucose level and a urine sugar level, or industrially. Is widely used in applications such as sampling quality inspection of products on the production line.

  As a biosensor system using the biosensor chip, for example, there is a quantitative analysis device described in Patent Document 1. This quantitative analyzer has a configuration that allows a disposable sensor (biosensor chip) to be connected to a measurement circuit via a connector terminal. After the connector terminal is connected, a switch is turned on and the battery as a power source is disposable via an operational amplifier. A voltage can be applied to the sensor (biosensor chip).

In this disposable sensor (biosensor chip), a difference (measurement error) may occur in the measurement result of biological information based on variations in internal resistance or the like in the reaction part. For this reason, the measurement error is automatically detected by inserting a biosensor correction chip having a different resistance value into the measuring instrument for each use such as adjustment mode switching, machine difference correction / calibration, and unit switching. A method for correcting the noise is described in Patent Document 1.
Japanese Patent Publication No. 8-20412

  However, the conventional biosensor correction chip has a resistance with a different value for each application described above, and when the biosensor correction chip is inserted, the current value corresponding to the resistance value is detected on the measuring instrument side. , Correction of measured values, identification / selection of calibration curve, presence / absence of device abnormality based on concentration value, change of concentration unit, etc., but it is extremely troublesome to connect a biosensor correction chip for each application to a measuring instrument. Work is required.

  In addition, since each correction resistance value is a fixed value, it cannot flexibly cope with changes in the surrounding environment such as temperature and changes over time, and the measurement error cannot be corrected at the shipping stage. Further, it is necessary to prepare separate biosensor correction chips having resistances having different resistance values for each application such as adjustment mode switching, machine difference correction / calibration, and unit switching.

  Furthermore, since each biosensor correction chip corrects a measurement value based on a difference in resistance value (or current value), it becomes impossible to distinguish between a used biosensor chip and a correction chip. For example, there may be a case where the correction process using the used biosensor chip is erroneously executed by the control unit.

  The present invention has been made paying attention to the conventional problems as described above, and can be inserted into an insertion portion of a measuring instrument for measuring a biosensor chip, and a connector electrode provided at the inserting portion of the measuring instrument. A biosensor chip that can be automatically and reliably discriminated from a biosensor chip, and has a plurality of connection terminals for digital signal output that can be connected to the memory and storage means for storing different data for each production lot of biosensor chips. An object is to obtain a sensor correction chip and a biosensor system.

In order to achieve the above object, the biosensor correction chip according to the present invention can be inserted into an insertion part of a measuring instrument for measuring the biosensor chip, and has a plurality of terminals provided in the insertion part of the measuring instrument. A connection electrode for digital signal output having a plurality of terminals connectable to the connector electrode;
Storage means for storing different data for each production lot of the biosensor chip,
The data read from the storage means is configured to be transmitted to the measuring device via the connection electrode and the connector electrode,
When the connection electrode is connected to the connector electrode by inserting into the insertion portion of the measuring instrument, the voltage level appearing at the first terminal among the plurality of terminals of the connector electrode is different from the case where the biosensor chip is inserted. Therefore, the biosensor chip can be distinguished from the biosensor chip.

  In addition, when the terminal of the connection electrode of the biosensor chip connected to the first terminal of the connector electrode is open, a pull-down resistor is connected to the terminal of the connection electrode connected to the first terminal of the connector electrode. Are preferably connected.

  In addition, when the terminal of the connection electrode of the biosensor chip connected to the second terminal of the connector electrode is at the ground potential, the terminal of the connection electrode connected to the second terminal of the connector electrode is used for pull-down. A resistor is preferably connected.

  The data is calibration curve data for correcting a calibration curve, and the calibration curve data preferably includes a plurality of coefficients to be substituted into the calibration curve calculation formula.

  The storage means preferably stores lot management data.

Preferably, the storage means is a rewritable nonvolatile memory, particularly an I ² CEEPROM provided with ^two signal lines for serial clock and serial data.

In addition, the biosensor system according to the present invention can be inserted into an insertion portion of a measuring instrument for measuring a biosensor chip, and can be connected to a connector electrode having a plurality of terminals provided in the insertion portion of the measuring instrument. A biosensor correction chip comprising a connection electrode for digital signal output having a plurality of terminals, and storage means for storing different data for each production lot of the biosensor chip;
When the biosensor correction chip is inserted into the insertion portion and the connection electrode is connected to the connector electrode, the voltage level appearing at the first terminal among the plurality of terminals of the connector electrode is inserted into the biosensor chip. And a measuring instrument provided with a chip discriminating means for discriminating the type of the chip depending on the case.

  The biosensor correction chip includes a connection electrode connected to the first terminal of the connector electrode when the connection terminal of the biosensor chip connected to the first terminal of the connector electrode is open. It is preferable that a pull-down resistor is connected to the terminal.

  The biosensor correction chip includes a second connector electrode when the connection electrode terminal of the biosensor chip connected to the second terminal among the plurality of terminals of the connector electrode is at a ground potential. It is preferable to provide a pull-down resistor at the terminal of the connection electrode connected to the terminal.

  According to the biosensor correction chip and the biosensor system of the present invention, it is possible to automatically detect the insertion of the chip, and to automatically determine whether the inserted chip is a biosensor chip or a biosensor correction chip. And surely.

Hereinafter, a biosensor correction chip and a biosensor system according to an embodiment of the present invention will be described with reference to the drawings.
In the present embodiment, blood is taken as an example of a biological material (sample) supplied to the biosensor chip, and a biosensor system that measures a blood glucose level in the blood will be described as an example.

FIG. 1 is a circuit diagram showing a measuring instrument connected to the biosensor correction chip according to the present embodiment, FIG. 2 is a circuit diagram showing the measuring instrument in a state where the biosensor chip is connected to the measuring instrument, and FIG. It is a timing chart of the voltage and current waveform of each part.
A biosensor system using the biosensor chip 1 will be described with reference to FIGS. 2 and 3. This biosensor system includes a biosensor chip 1, a biosensor correction chip 14, and a measuring instrument 2 that measures biological information of a biological material supplied to the biochip sensor 1.

Among these, the biosensor chip 1 includes a reaction unit 4 that is provided so as to be connected to connection electrodes (hereinafter referred to as connection electrodes) 3 as a plurality of sensor electrodes and to which a biological substance is supplied (dropped). Yes. The connection electrode 3 includes five terminals a to e.
For example, the reaction unit 4 is configured for blood sugar level reaction, and is formed of a mixture of an oxidoreductase and an electron conductor (mediator), for example, a mixture of glucose oxidase and potassium ferricyanide.

The measuring instrument 2 includes a connector electrode 6 and a control unit 7. Among these, the connector electrode 6 includes five terminals a to e.
The control unit 7 includes an analog / digital conversion circuit (hereinafter referred to as ADC) 9, a biological information measurement circuit 10, a memory 11, a chip determination unit 12, and a digital / analog conversion circuit (hereinafter referred to as DAC) 13. The chip discriminating means 12 is the biosensor chip 1 that is inserted into the insertion portion 5 (connected to the connector electrode 6) according to whether the chip discriminating signal described later is high level or low level, or the biosensor correction chip 14 described later. It is discriminate | determining whether it is.

  The ADC 9 is provided with a bypass circuit and a switch (both not shown) for directly connecting the connector electrode 6 and the biological information measuring circuit 10. In addition, the biological information measurement circuit 10 functions to raise the voltage applied to the reaction unit 4 to a predetermined level through the DAC 13 by inserting the biosensor chip 1 into the insertion unit 5.

  When blood is supplied to the reaction unit 4, the biological information measurement circuit 10 applies a voltage applied to the reaction unit 4 for a predetermined time at a level equal to or lower than the oxidation-reduction potential (for example, 0.33 V when the reaction material is potassium ferricyanide). Function to maintain. As a result, the generation of charges by the enzymatic reaction of the blood is promoted.

  Further, the biological information measuring circuit 10 functions to measure the reaction current value due to the charge discharge of the reaction unit 4 within the predetermined time after the applied voltage of the predetermined level is raised again within the set time.

  The DAC 13 can continuously generate an applied voltage having a variable level of 0 V or higher, and functions to arbitrarily set a predetermined level of voltage in the reaction unit 4 via the connection electrode 3 and the connector electrode 6.

Therefore, in this embodiment, as shown in FIG. 3, the predetermined time including the time of dropping the blood from the insertion timing t1 to the insertion portion 5 of the biosensor chip 1 and the period including the time from t3 to t4 are predetermined high. Can be set to voltage. Further, the period including the time from t2 to t3 can be set to a voltage equal to or lower than the oxidation-reduction potential.
The memory 11 stores information obtained from the biosensor correction chip 14.

Next, the operation of this measuring device will be described with reference to the timing chart of FIG.
First, at the start of measurement of a biological substance such as blood, an applied voltage is output from the DAC 13 of the control unit 7, and the biosensor chip 1 is inserted into the insertion unit 5 of the measuring device 2.
At this time, the applied voltage is applied to the reaction unit 4 via the connection electrode 3 and the connector electrode 6.

  Therefore, a current flows through the reaction unit 4 by this applied voltage, and this current is input to the biological information measurement circuit 10 of the control unit 7 via the ADC 9 at t1 in FIG.

  After inserting the biosensor chip 1 into the insertion portion 5 in this way, at time t2 after a predetermined time has elapsed, a biological substance, here blood, is supplied (dropped) onto the reaction portion 4. The reaction current flowing through the reaction unit 4 due to the dripping of blood rises instantaneously as shown in FIG. The controller 7 recognizes this drop of blood based on the pulsed current that rises instantaneously.

  Subsequently, the control unit 7 applies a voltage equal to or lower than the redox potential from the DAC 13 to the reaction unit 4 via the connection electrode 3 and the connector electrode 6. The control unit 7 maintains the low voltage applied to the reaction unit 4 for a preset standing period (until t3), and accumulates charges generated by a chemical (enzyme) reaction of blood in the reaction unit 4 during this period.

  Next, the control unit 7 applies the voltage of the predetermined level from the DAC 13 to both ends of the reaction unit 4 again at t3 when the leaving period from t2 elapses. As a result, a reaction current as shown in FIG. 3B is released to the reaction unit 4 in accordance with the resistance value change based on the enzyme reaction. A voltage corresponding to the reaction current value is applied to the control unit 7 as described above.

  The reaction current sharply rises to a predetermined high level when an applied voltage is applied, and then gradually decreases according to a discharge time constant of the charge in the reaction section 4. Therefore, the reaction current value is sampled at a predetermined timing t4 near the end of the gradual decrease operation of the reaction current.

Then, using a calibration curve showing the relationship between the current value and the blood glucose level, the blood glucose level is calculated from the collected reaction current value.
For example, the calculation is performed using the following calibration curve calculation formula.
(Formula 1)
When I <G,
Y = (A1−B1 × T) × I ² + (C1−D1 × T) × I + (E1−F1 × T)
(Formula 2)
When I ≧ G
Y = (A2−B2 × T) × I ² + (C2−D2 × T) × I + (E2−F2 × T)

Here, Y is blood glucose level, I is reaction current value, T is measurement environment temperature, G is calibration curve selection threshold, A1 to F1 are calibration curve counts when I <G, and A2 to F2 are I ≧ G It is the count of the calibration curve.
By the way, the biosensor chip 1 has different values (calibration curve data) of A1 to F1, A2 to F2, and G in the above formulas 1 and 2 for each production lot. It is stored in the EEPROM 15 of the chip 14.

  In this embodiment, before the measurement by the biosensor chip 1, the biosensor correction chip 14 is connected and the calibration curve data of the production lot to which the biosensor chip 1 belongs is transmitted to the measuring device 2 in advance. Thereby, the blood glucose level can be calculated using the calibration curve data corresponding to the production lot of the biosensor chip 1 in the calibration curve calculation formula (the formula 1 or the formula 2).

  The biosensor correction chip 14 is an example of a rewritable nonvolatile memory and has an electrically rewritable EEPROM 15 as storage means. The EEPROM 15 stores the calibration curve data (A1 to F1, A1 to F1, G). In addition to (value), the lot management data includes the lot number of the biosensor chip, the date of manufacture, the number of biosensor chips in the production lot, the lot number of the biosensor correction chip, and the like. Data is also transmitted as a digital signal to the control unit 7 together with the calibration curve data.

The biosensor correction chip 14 includes a connection electrode 16 for digital signal output that can be connected to the connector electrode 6 of the measuring instrument 2.
Further, as described above, the control unit 7 is provided with the memory 11. The memory 11 stores calibration curve data corresponding to the production lot transmitted from the biosensor correction chip 14.

  The biosensor correction chip 14 provided with the EEPROM 15 has different information for each production lot of the biosensor chip 1 as described above. Therefore, when biometric information is measured using the biosensor chip 1, the biosensor correction chip 14 prepared in advance for the biosensor chip 1 of the same production lot is inserted in the insertion unit 5 in advance, and the EEPROM 15 is previously stored. The stored information is input to the measuring device 2.

  The biological information measurement circuit 10 reads calibration curve data in the memory 11. Thereafter, the reaction current value obtained from the biosensor chip 1 inserted in place of the biosensor correction chip 14 is used as a calibration curve calculation formula (formula 1) of calibration curve data corresponding to the manufacturing lot of the biosensor chip 1 or The blood glucose level is calculated using (Equation 2).

  As a result, the biological information measurement circuit 10 outputs and displays an accurate blood glucose level (biological information value) without causing an error in the output of the biosensor chip 1 for each manufacturing lot.

  The lot management data stored in the EEPROM 15 in advance, for example, information such as the lot number of the biosensor chip 1, the date of manufacture, the number of biosensor chips 1 of the manufacturing lot, the lot number of the biosensor correction chip, etc. At the same time, it is transmitted to the measuring instrument 2 and stored in the memory 11.

  By using such lot management data, for example, it can be determined whether or not all the biosensor chips 1 of the same production lot as the biosensor correction chip have been used. Alternatively, it is possible to determine whether or not the date of manufacture of the biosensor chip 1 has expired.

  The measuring device 2 can be configured to be connectable to a server or the like via a PC or a network. By using the measuring instrument 2 configured as described above, a new production lot data is acquired via a PC or a network, and the calibration stored in the EEPROM 15 which is a rewritable storage means of the biosensor correction chip 14. Information such as line data can be easily rewritten to data of a new production lot.

  Next, a biosensor chip and a biosensor system according to an embodiment of the present invention will be described with reference to the drawings. 4 is a circuit diagram of a biosensor chip, FIG. 5 is a circuit diagram of a biosensor correction chip, FIG. 6 is a circuit diagram of an input / output unit of the measuring instrument, and FIG. 7 is a voltage waveform when a chip inserted into the measuring instrument is identified. FIG.

  As shown in FIG. 4, the biosensor chip 1 has a connection electrode 3 and a reaction part 4, and the connection electrode 3 has terminals a to e. Terminals a and b are connected to each other and further connected to the reaction unit 4. Terminals c, d, and e are all open.

  As shown in FIG. 5, the biosensor correction chip 14 has an EEPROM 15 and a connection terminal 16 as storage means. The connector electrode 6 includes terminals a to e, and these sizes and numbers correspond to the terminals a to e of the connection terminal 16.

  The EEPROM 15 has a power supply (Vcc) terminal, a serial clock (SCL) terminal, and a serial data (SDA) terminal, and the power supply terminal is connected to the terminal c of the connection electrode 16. The serial clock terminal is connected to the terminal b (second terminal) of the connection electrode 16 through the inductance L1. The serial data terminal is connected to the terminal (first terminal) d of the connection electrode 16 via the inductance L2.

  The terminal a of the connection electrode 16 is grounded, and a resistor (for example, 10 kΩ) R1 is connected between the terminal a and the terminal b. The terminal d of the connection electrode 16 is grounded via a resistor (for example, 10 kΩ) R2. The terminal e of the connection electrode 16 is in an open state. The EEPROM 15 is connected with a diode D and a capacitor C for stabilizing the power supply voltage.

FIG. 6 shows a circuit configuration of an input / output unit (chip insertion detection unit) in the measuring instrument 2. The terminal a of the connector electrode 6 constituting the input / output unit is grounded, and the terminal b is connected to a serial clock signal (SCL) output, a chip detection input TB0, and a chip detection voltage output P1 including a resistor R3.
The terminal c of the connector electrode 6 is connected to the power source Vcc. The terminal d of the connector electrode 6 is connected to the power supply (Vcc) side via a resistor R4 (for example, 100 kΩ), and via a resistor R5 and a P3 that serves as a serial data signal (SDA) input and a chip discrimination signal. Each is connected to a pull-up signal output P2. A terminal e of the connection electrode 16 is connected to an amplifier A that amplifies the measurement current.

  Next, a method of discriminating between the biosensor chip 1 and the biosensor correction chip 14 in the measuring instrument 2 will be described according to the timing chart of each part of the circuit shown in FIG. Note that a predetermined voltage (for example, 3.3 V) is applied to the chip detection voltage output P1 in the input / output unit (chip insertion detection unit) in the measuring instrument 2 (FIG. 7A). TB0 is kept at a predetermined high potential.

  Here, the biosensor chip 1 is inserted into the insertion portion 5 of the measuring instrument 2, and the connection electrode 3 of the biosensor chip 1 as shown in FIG. 4 is connected to the connector electrode 6 of the measuring instrument 2 as shown in FIG. Connect to. As a result, the potential of the chip detection input TB0 is pulled to the ground potential side via the terminals a and b of the electrodes 3 and 6 and becomes a low level (FIG. 7B). Thereby, it is detected by the chip | tip discrimination | determination means 12 of the measuring device 2 that the chip | tip (either the biosensor chip | tip 1 or the biosensor correction | amendment chip | tip 14) was inserted.

  Further, since the terminals c and d of the connection electrode 3 are in an open state, the chip discrimination signal P3 connected to the power source Vcc of the measuring instrument 2 via the resistor R4 is at the same level as Vcc. That is, as shown in FIG. 7E, when the biosensor chip 1 is connected, if Vcc is high level, the chip discrimination signal P3 becomes high level LV1, and the chip inserted by the chip discrimination means 12 Is determined to be the biosensor chip 1.

  On the other hand, when the biosensor correction chip 14 is connected to the measuring instrument instead of the biosensor chip 1, the chip detection input TB0 is grounded via the resistor R1, and the potential of the chip detection input TB0 is as shown in FIG. As shown in 7 (b), the low level is maintained. Thereby, it is detected by the chip | tip discrimination | determination means 12 of the measuring device 2 that the chip | tip (either the biosensor chip | tip 1 or the biosensor correction | amendment chip | tip 14) was inserted. Then, as shown in FIG. 7C, the operating power is applied to the EEPROM 15 from the power source Vcc through each terminal c of the connector electrode 6 and the connection electrode 16.

  The chip discrimination signal P3 is connected to the power source Vcc via the pull-up resistor R4. A pull-up signal output P2 is connected to the chip discrimination signal P3 via a resistor R5. Accordingly, when the connection electrode 16 is connected to the connector electrode 6, the potential of the chip discrimination signal P3 is as shown in FIG. 7 (e) by the pull-down resistor R2 connected to each terminal d of the electrodes 6 and 16. In addition, the voltage drops to LV2 of about 1/10 level.

  In addition, after the chip is determined as described above, serial data (SDA) is transmitted and received between the biosensor correction chip 14 and the measuring instrument 2. When data is transmitted from the measuring instrument 2 to the biosensor correction chip 14 (during transmission), P2 is set to a low level as shown in FIG. 7D, and serial data (from P3 as shown in FIG. SDA) is transmitted to the biosensor correction chip 14. When the measuring instrument 2 receives data from the biosensor correction chip 14 (during reception), P2 is set to the high level as shown in FIG. 7D, and P3 is set as shown in FIG. 7E. Serial data (SDA) is received from the biosensor correction chip 14.

As described above, according to the embodiment of the present invention, either the connection electrode 3 on the biosensor chip 1 side or the connection electrode 16 on the biosensor correction chip 14 is connected to the connector electrode 6 of the measuring instrument 2. Since the potential of the chip detection input TB0 is lowered, by detecting this potential, it is possible to detect and display on the measuring instrument 2 side that these connections have been made.
Furthermore, when the connection electrode 3 on the biosensor chip 1 side is connected to the connector electrode 6 of the measuring instrument 2, the potential of the chip discrimination signal P3 does not change, but the connection electrode 16 on the biosensor correction chip 14 side is connected. In this case, the type of the chip connected to the measuring instrument 2 can be determined by decreasing the potential of the chip determination signal P3.

The measuring instrument 2 and the biosensor correction chip 14 can exchange digital signals by using two signal lines for SCL (serial clock) and SDA (serial data) by the I ² C communication method. The number of signal pins excluding the power supply pins and the ground pins on the biosensor correction chip 14 side connecting them can be reduced, and high-speed serial communication is possible.

  As described above in detail, according to the biosensor correction chip 14 and the biosensor system according to the present embodiment, the blood glucose level measured by the biosensor chip 1 is accurately measured based on the difference in the calibration curve for each production lot. The biosensor correction chip 14 can automatically detect the insertion of the biosensor correction chip and automatically and reliably determine whether the inserted chip is a biosensor chip or a biosensor correction chip. it can.

It is a circuit diagram which shows the measuring device equipped with the biosensor correction chip concerning this embodiment. It is a circuit diagram which shows the measuring device equipped with the biosensor chip in this embodiment. 3 is a timing chart of current and voltage in each part of the biological information measurement circuit shown in FIG. 1. It is a circuit diagram which shows the biosensor chip in this embodiment. It is a circuit diagram which shows the biosensor correction | amendment chip | tip which concerns on this embodiment. It is a circuit diagram which shows the input / output part of the measuring device in this embodiment. It is a wave form diagram of the voltage in each part of the input-output part in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Biosensor chip 2 Measuring device 3 Connection electrode 4 Reaction part 5 Insertion part 6 Connector electrode 7 Control part 9 Analog / digital conversion circuit (ADC)
DESCRIPTION OF SYMBOLS 10 Biological information measurement circuit 11 Memory 12 Chip discrimination means 13 Digital / analog conversion circuit (DAC)
14 Biosensor correction chip 15 EEPROM (memory means)
16 Connection terminal

Claims (10)

Connection for digital signal output having a plurality of terminals connectable to a connector electrode having a plurality of terminals provided in the insertion section of the measuring instrument, which can be inserted into the inserting section of the measuring instrument for measuring the biosensor chip Electrodes,
Storage means for storing different data for each production lot of the biosensor chip,
The data read from the storage means is configured to be transmitted to the measuring device via the connection electrode and the connector electrode,
When the connection electrode is connected to the connector electrode by inserting into the insertion portion of the measuring instrument, the voltage level appearing at the first terminal among the plurality of terminals of the connector electrode is different from the case where the biosensor chip is inserted. The biosensor correction chip is configured to be distinguishable from the biosensor chip.   When the terminal of the connection electrode of the biosensor chip connected to the first terminal of the connector electrode is open, a pull-down resistor is connected to the terminal of the connection electrode connected to the first terminal of the connector electrode The biosensor correction chip according to claim 1, wherein:   When the terminal of the connection electrode of the biosensor chip connected to the second terminal of the connector electrode is at a ground potential, a pull-down resistor is connected to the terminal of the connection electrode connected to the second terminal of the connector electrode. The biosensor correction chip according to claim 1, wherein the biosensor correction chip is connected.   The bio data according to any one of claims 1 to 3, wherein the data is calibration curve data for correcting a calibration curve, and the calibration curve data includes a plurality of coefficients to be substituted into a calibration curve calculation formula. Sensor correction chip.   The biosensor correction chip according to claim 1, wherein lot management data is stored in the storage unit.   The biosensor correction chip according to claim 1, wherein the storage unit is a rewritable nonvolatile memory. 7. The biosensor correction chip according to claim 6, wherein the storage means is an I2CEEPROM provided with ^two signal lines for a serial clock and serial data. Connection for digital signal output having a plurality of terminals connectable to a connector electrode having a plurality of terminals provided in the insertion section of the measuring instrument, which can be inserted into the inserting section of the measuring instrument for measuring the biosensor chip A biosensor correction chip comprising an electrode and storage means for storing different data for each production lot of the biosensor chip;
When the biosensor correction chip is inserted into the insertion portion and the connection electrode is connected to the connector electrode, the voltage level appearing at the first terminal among the plurality of terminals of the connector electrode is inserted into the biosensor chip. A biosensor system comprising: a measuring device including a chip discriminating unit that discriminates the type of the chip depending on the case.   In the biosensor correction chip, when the connection terminal of the biosensor chip connected to the first terminal of the connector electrode is open, the terminal of the connection electrode connected to the first terminal of the connector electrode The biosensor system according to claim 8, wherein a pull-down resistor is connected.   In the biosensor correction chip, when the terminal of the connection electrode of the biosensor chip connected to the second terminal among the plurality of terminals of the connector electrode is at the ground potential, the second terminal of the connector electrode The biosensor system according to claim 8 or 9, wherein a pull-down resistor is provided at a terminal of the connection electrode connected to the terminal.

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