JP2009159984A - Agent for food and drink for elevation of body temperature - Google Patents

Agent for food and drink for elevation of body temperature Download PDF

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JP2009159984A
JP2009159984A JP2009097182A JP2009097182A JP2009159984A JP 2009159984 A JP2009159984 A JP 2009159984A JP 2009097182 A JP2009097182 A JP 2009097182A JP 2009097182 A JP2009097182 A JP 2009097182A JP 2009159984 A JP2009159984 A JP 2009159984A
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body temperature
tyrosine
agent
food
amino acid
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JP4829322B2 (en
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Hajime Sumio
肇 角尾
Katsuyuki Uchida
勝幸 内田
Takae Wakabayashi
孝枝 若林
Yasuko Sawai
保子 澤井
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Meiji Dairies Corp
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Meiji Milk Products Co Ltd
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition having activity for elevating body temperature, exhibiting the effects rapidly, continuing the activity thereafter and having excellent palatability. <P>SOLUTION: The agent for a food and drink for the elevation of the body temperature contains only tyrosine as an amino acid as an active ingredient, or contains only the tyrosine, aspartic acid, glutamic acid and alanine (four kinds of amino acids) as active ingredients. The agent is provided by the affirmation of the activity for elevating the body temperature, possessed by the tyrosine, and the effects of elevating the body temperature, burning the body fat by the activation of metabolic action thereby, reducing the accumulation of the body fat and ameliorating cold constitution are exhibited by the administration of the agent. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

本発明は、体温を上昇させるのに有効な飲食品用の剤に関するものであり、更に詳細には、本発明の剤は、特定のアミノ酸、特にチロシンを有効成分として含有するものであって、すぐれた生理作用、特に、すぐれた体温上昇作用を有する。また、本発明に係る剤は、体温上昇作用により体内の代謝を促進することから、基礎代謝の改善、さらには体脂肪蓄積の低下、冷え性の改善、寒冷地に冷めた身体を温める手段としても有効である。   The present invention relates to an agent for foods and drinks effective for increasing body temperature, and more specifically, the agent of the present invention contains a specific amino acid, particularly tyrosine as an active ingredient, It has excellent physiological action, particularly excellent body temperature raising action. In addition, since the agent according to the present invention promotes metabolism in the body by increasing body temperature, it improves basal metabolism, further reduces body fat accumulation, improves coldness, and as a means of warming a body cooled in a cold region. It is valid.

従来、辛味香辛料成分のエネルギー代謝を促進する作用に着目したものとして、カプサイシン類を有効成分とする飲料(例えば、特許文献1参照)などが知られている。   Conventionally, beverages that contain capsaicins as active ingredients (for example, see Patent Document 1) are known as those that focus on the action of promoting energy metabolism of spicy spice ingredients.

特開2000−189121号公報JP 2000-189121 A

体温上昇効果があるといわれるカプサイシン類は唐辛子に含まれる辛味成分である。多量のカプサイシン類を加えると辛みを強く感じるため、添加する量に制限があった。また、身体を温めるには温かい飲食物を摂取し体内に熱を取り込む方法も考えられるが、これでは効果も一過性である。そこで、エネルギー代謝改善作用を有する組成物としては、速やかに効果が得られ、その後も作用が継続すること、経口摂取する場合には、嗜好性にも優れることなどが求められる。   Capsaicins, which are said to have an effect of increasing body temperature, are pungent components contained in chili peppers. When a large amount of capsaicin was added, the amount of addition was limited because it felt strongly hot. Moreover, in order to warm a body, the method of ingesting heat food and taking heat into a body can also be considered, but this is also a temporary effect. Therefore, a composition having an action for improving energy metabolism is required to have an effect quickly, to continue its action thereafter, and to have excellent palatability when taken orally.

上記目的を達成するため、本発明者らは、各方面から検討の結果、多数のアミノ酸組成物に着目した。アミノ酸の種類、その組合せ、配合量を変えて、非常に数多くのアミノ酸組成物を調製し、これらのアミノ酸組成物について、それらの生理作用をつぶさに検討した。その結果、基礎体温を上昇させ、その作用が長時間持続する特定組成のアミノ酸組成物をはじめて見出し、これらのアミノ酸群組成物について更に検討の結果、チロシンを高度に含有する組成物ほど体温上昇性が高いことをはじめて見出した。   In order to achieve the above object, the present inventors have focused on a large number of amino acid compositions as a result of examinations from various directions. Numerous amino acid compositions were prepared by changing the types of amino acids, combinations thereof, and blending amounts, and the physiological effects of these amino acid compositions were thoroughly examined. As a result, we first discovered amino acid compositions with a specific composition that raises basal body temperature and the action lasts for a long time, and as a result of further study on these amino acid group compositions, the higher the composition of tyrosine, the higher the body temperature. I found out for the first time that it is high.

そこで本発明者らは、このチロシンに着目して研究を行った結果、これを体温上昇アミノ酸と同定し、チロシンについて、本アミノ酸のみの体温上昇作用をin vivo試験によって確認し、更に研究の結果、遂に本発明の完成に至ったものである。
更にまた、本発明者らは、上記研究の課程において、チロシンにアスパラギン酸、グルタミン酸、アラニンを併用したところ、これら4種のアミノ酸のみによるすぐれた体温上昇効果が奏されることもはじめて確認し、更に研究の結果、遂に本発明の完成に至ったものである。
Therefore, the present inventors conducted research while paying attention to this tyrosine, and as a result, identified this as an amino acid that increases body temperature, and confirmed the effect of tyrosine alone on the increase in body temperature by in vivo testing. Finally, the present invention has been completed.
Furthermore, the present inventors have confirmed for the first time that, in the course of the above research, when aspartic acid, glutamic acid, and alanine are used in combination with tyrosine, an excellent effect of raising body temperature by only these four amino acids is achieved. As a result of further research, the present invention has finally been completed.

すなわち、本発明の実施形態は次のとおりである。
(1)アミノ酸としてチロシンのみを有効成分として含有すること、を特徴とする体温上昇飲食品用の剤(体温上昇性アミノ酸含有飲食品用の剤)。
(2)アミノ酸として、チロシン、アスパラギン酸、グルタミン酸、アラニンの4種アミノ酸のみを有効成分として含有すること、を特徴とする体温上昇飲食品用の剤(体温上昇性アミノ酸含有飲食品用の剤)。
(3)チロシンを200ml当り25mg以上、好ましくは200mg以上、更に好ましくは270mg以上含有すること、を特徴とする(1)又は(2)に記載の剤。
(4)チロシンを該アミノ酸群中45(重量)%以上、好ましくは50(重量)%以上含有すること、を特徴とする(2)又は(3)に記載の剤。
(5)(1)〜(4)のいずれか1つに記載の有効成分と飲食品用に常用される添加料のみからなること、を特徴とする体温上昇飲食品用の剤(体温上昇性アミノ酸含有飲食品用の剤)。
(6)(1)〜(4)のいずれか1つに記載の剤を含有すること、を特徴とする体温上昇飲食品(体温上昇性アミノ酸含有飲食品)。
That is, the embodiment of the present invention is as follows.
(1) An agent for increasing body temperature food / beverage products, comprising only tyrosine as an active ingredient as an amino acid (agent for food / beverage products containing body temperature increasing amino acids).
(2) As an amino acid, it contains only four kinds of amino acids tyrosine, aspartic acid, glutamic acid, and alanine as active ingredients, and an agent for body temperature rising food or drink (agent for body temperature raising amino acid-containing food or beverage) .
(3) The agent according to (1) or (2), wherein tyrosine is contained in an amount of 25 mg or more per 200 ml, preferably 200 mg or more, more preferably 270 mg or more.
(4) The agent according to (2) or (3), wherein tyrosine is contained in the amino acid group in an amount of 45 (wt)% or more, preferably 50 (wt)% or more.
(5) An agent for increasing body temperature food and drink, comprising only the active ingredient according to any one of (1) to (4) and an additive commonly used for food and drink (body temperature increasing property) Agents for amino acid-containing foods and drinks).
(6) A body temperature-elevating food or drink (containing a body temperature-elevating amino acid-containing food or drink), comprising the agent according to any one of (1) to (4).

本発明者らによって、特定のアミノ酸群からなる有効成分に、すぐれた体温上昇作用を有するという新規用途が見出され、その本体がチロシンであることもはじめて明らかにされた。チロシンのみからなる、又は、チロシンを含有してなる本件発明に係る体温上昇飲食用の剤は、これを投与することで、日常生活での体温の上昇から消費エネルギーが上昇し、基礎代謝が高くなるという著効を奏する。また基礎体温の上昇、体脂肪蓄積の低下や冷え性の改善等にも有効であり、低毒性であるため、長期間摂取することが可能である。   The present inventors have found a novel use that an active ingredient comprising a specific amino acid group has an excellent effect of raising body temperature, and it has been revealed for the first time that its main body is tyrosine. The agent for eating and drinking a body temperature increase according to the present invention consisting only of tyrosine or containing tyrosine increases the energy consumption due to the increase in body temperature in daily life, and the basal metabolism is high. Has the remarkable effect of becoming. It is also effective for raising basal body temperature, reducing body fat accumulation, improving coldness, etc., and has low toxicity and can be taken for a long time.

チロシンを各用量でラットに投与した場合の最高基礎体温上昇度の平均を示すグラフである。It is a graph which shows the average of the highest basal body temperature rise degree when tyrosine is administered to a rat at each dose. 同じく、各経過時間における基礎体温上昇温度の平均を示すグラフである。Similarly, it is a graph which shows the average of the basal body temperature rise temperature in each elapsed time. 同じく、各経過時間における基礎体温の平均を示すグラフである。Similarly, it is a graph which shows the average of the basal body temperature in each elapsed time. 本発明に係るアミノ酸組成物(4種アミノ酸)をラットに投与した場合の最高基礎体温上昇度の平均を示すグラフである。It is a graph which shows the average of the highest basal body temperature rise degree at the time of administering the amino acid composition (4 types of amino acids) which concerns on this invention to a rat. 同じく、各経過時間における基礎体温上昇温度の平均を示すグラフである。Similarly, it is a graph which shows the average of the basal body temperature rise temperature in each elapsed time.

以下、本発明について詳細に説明する。   Hereinafter, the present invention will be described in detail.

本発明は、体温上昇アミノ酸の本体がチロシンであることをはじめてつきとめたものであって、本発明に係る剤の有効成分はチロシンであることを特徴とするものであり、チロシンとしては、それ単独で独立して分離ないし取り出したものであって、ひとつの化合物として単離されたものをいい、市販品も適宜使用可能である。また、チロシン(1種アミノ酸)を含む上記した4種のアミノ酸(4種アミノ酸)もすぐれた体温上昇作用を有し、本発明に係る剤の有効成分として使用可能である。なお、チロシンのほか各種アミノ酸は、天然物(発酵によるものも含む)及び合成品のいずれも使用可能であるが、後者の場合、D型よりもL型が好ましいがラセミ体も使用可能である。   The present invention has been found for the first time that the body of the amino acid for raising body temperature is tyrosine, and the active ingredient of the agent according to the present invention is tyrosine, and tyrosine alone In this case, the product is isolated or taken out independently and isolated as a single compound, and a commercially available product can be used as appropriate. In addition, the above four amino acids (four amino acids) including tyrosine (one amino acid) also have an excellent body temperature raising action and can be used as an active ingredient of the agent according to the present invention. In addition to tyrosine, various amino acids, both natural products (including fermented ones) and synthetic products, can be used. In the latter case, the L form is preferred over the D form, but the racemic form can also be used. .

したがって、本発明に係るアミノ酸として「チロシンのみ」を有効成分とする剤においては、有効成分はチロシンのみであって、有効成分としてチロシンのほかに他のアミノ酸、ペプチド、食品その他の体温上昇成分の併用を指すものではない。4種アミノ酸の場合も同様である。   Therefore, in the agent having “tyrosine only” as the active ingredient as the amino acid according to the present invention, the active ingredient is only tyrosine, and in addition to tyrosine, other amino acids, peptides, foods and other body temperature raising components It does not indicate combined use. The same applies to the case of four amino acids.

本発明に係る剤は、チロシンのみ、あるいはチロシン、アスパラギン酸、グルタミン酸、アラニンのアミノ酸4種のみを有効成分とするものであるが、本発明に係る剤の有効成分としては、次の態様1、2が挙げられる。   The agent according to the present invention contains tyrosine alone or only four amino acids of tyrosine, aspartic acid, glutamic acid, and alanine as active ingredients. The active ingredient of the agent according to the present invention includes the following aspects 1, 2 is mentioned.

(態様)
(1)1種アミノ酸:チロシン
(2)4種アミノ酸:チロシン+(アスパラギン酸、グルタミン酸、アラニン)
(Aspect)
(1) 1 amino acid: tyrosine (2) 4 amino acids: tyrosine + (aspartic acid, glutamic acid, alanine)

上記した4種アミノ酸(態様2)の場合において、各アミノ酸の配合割合(重量%)は、例えば次のようにすることができる。
チロシン:40〜65(好適域45〜60)
アスパラギン酸:0.1〜10(好適域0.5〜5)
グルタミン酸:10〜35(好適域15〜30)
アラニン:10〜40(好適域15〜35)
(もちろん、上記配合は1例として示したものであって、上記配合において、チロシン含量を更に高めることも可能である。)
In the case of the above-mentioned four kinds of amino acids (Aspect 2), the blending ratio (% by weight) of each amino acid can be set as follows, for example.
Tyrosine: 40-65 (preferable range 45-60)
Aspartic acid: 0.1 to 10 (preferable range 0.5 to 5)
Glutamic acid: 10 to 35 (preferable range 15 to 30)
Alanine: 10-40 (preferable range 15-35)
(Of course, the above formulation is shown as an example, and the tyrosine content can be further increased in the above formulation.)

本発明に係る剤は、チロシンを有効成分とするものであるが、チロシンは単独でもよいし他のアミノ酸と共存してアミノ酸群(4種アミノ酸)を構成していてもよく、その場合、各アミノ酸は、それぞれ特定の組成割合で含有されることが好適であって、以下に示される。   The agent according to the present invention contains tyrosine as an active ingredient, but tyrosine may be used alone or together with other amino acids to constitute an amino acid group (four kinds of amino acids). Each amino acid is preferably contained in a specific composition ratio, and is shown below.

すなわち、各アミノ酸が、チロシン0.5〜15モル以上、アスパラギン酸0.02〜0.4モル、グルタミン酸0.3〜7モル、アラニン0.7〜14モルの割合で含むことが好ましい。   That is, it is preferable that each amino acid contains tyrosine 0.5 to 15 mol or more, aspartic acid 0.02 to 0.4 mol, glutamic acid 0.3 to 7 mol, and alanine 0.7 to 14 mol.

本発明に係る剤の有効成分を構成するチロシンを含むアミノ酸群(4種アミノ酸(4AA))の具体例を下記表1に示す。   Specific examples of amino acid groups (4 amino acids (4AA)) containing tyrosine that constitute the active ingredient of the agent according to the present invention are shown in Table 1 below.

Figure 2009159984
Figure 2009159984

本発明に係る体温上昇飲食品用の剤は、アミノ酸としてチロシンのみ又はチロシンを含む4種アミノ酸群のみを含有成分又は有効成分とするものであり、本有効成分のみをそのまま混合してあるいは混合することなく、粉末状や水溶液状にして経口摂取してもよいが、含有又は有効成分は液状であっても、固状であっても、味がよくなく、又飲み込みにくいなどの場合にあっては、含有又は有効成分と飲食品用に常用される添加料を用いて、味をよくして飲みやすくしたり、全体をビスケット状にして食べやすくしたりするのがよい。例えば、ドリンク剤は、含有又は有効成分水性液にクエン酸などの酸味料や砂糖などの甘味料を添加してのみやすくすることができる。又、粉末混合状態の有効成分に精製澱粉などを加え、混合し、焼き上げて、ビスケット状とすれば、おいしく食べることができるようになる。   The agent for increasing body temperature food / beverage products according to the present invention contains only tyrosine as an amino acid or only four kinds of amino acids containing tyrosine as a component or active ingredient, and the active ingredient alone is mixed or mixed as it is. It may be taken orally in powder or aqueous solution, but the contained or active ingredient may be liquid, solid, tasteless, and difficult to swallow. It is preferable to improve the taste and make it easy to drink, or to make it easy to eat in the form of biscuits, using contained or active ingredients and additives commonly used for food and drink. For example, the drink can be made easy only by adding an acidulant such as citric acid or a sweetener such as sugar to the contained or active ingredient aqueous liquid. Moreover, if refined starch etc. are added to the active ingredient of a powder mixed state, and it mixes and baked, and it becomes a biscuit shape, it will be able to eat deliciously.

本発明に係る体温上昇飲食品用の剤は、既述したように、粉末状のままで摂取しても、あるいは水に溶解して水溶液等として摂取しても良い。   As described above, the agent for increasing body temperature food or drink according to the present invention may be ingested as a powder, or may be dissolved in water and ingested as an aqueous solution or the like.

上述のように飲みやすくし、食べやすくして摂取する以外に、賦形剤、希釈剤と共に混合し、散剤、顆粒剤、錠剤、カプセル剤、トローチ剤等として用いてもよい。但し固体散剤や錠剤では吸収に時間を要することがあるため、有効成分自体の経口投与が望ましい。この場合には、適切な添加剤、例えば塩化ナトリウムのような塩類、pH調節剤、キレート剤と共に前述した溶液として投与しても良い。   In addition to making it easy to drink and easy to eat as described above, it may be mixed with excipients and diluents and used as powders, granules, tablets, capsules, troches and the like. However, since solid powders and tablets may take time to absorb, oral administration of the active ingredient itself is desirable. In this case, it may be administered as a solution described above together with a suitable additive, for example, a salt such as sodium chloride, a pH adjusting agent, and a chelating agent.

摂取時期にも格別の制限はなく、任意の時期に摂取すればよく、例えばドリンク剤(清涼飲料、粉末飲料、乳酸菌飲料、ドリンクヨーグルト、乳酸飲料等の飲食品タイプ等を含む)として摂取すると好適である。ドリンク剤の場合、有効成分としてチロシンを、ドリンク剤200ml当り、25mg以上、好ましくは250mg以上、更に好ましくは2.5g以上含有するように製剤するのが好適である。   There is no particular restriction on the intake time, and it can be taken at any time. It is. In the case of a drink, it is preferable to formulate tyrosine as an active ingredient in an amount of 25 mg or more, preferably 250 mg or more, more preferably 2.5 g or more per 200 ml of drink.

本発明の体温上昇飲食品用の剤の投与量は広範囲に設定でき、有効成分量として通常1回に0.1〜5gを経口投与する。溶液として投与又は摂取する場合には、0.05〜10重量%程度の溶液として1回に10〜1000ml、好ましくは1〜4重量%として1回に100〜500ml投与又は摂取する。   The dosage of the agent for increasing body temperature food / beverage products of the present invention can be set in a wide range, and 0.1 to 5 g is usually orally administered at a time as an active ingredient amount. When administered or ingested as a solution, it is administered or ingested as a solution of about 0.05 to 10% by weight, 10 to 1000 ml at a time, preferably 1 to 4% by weight, or 100 to 500 ml at a time.

後述する実施例から明らかなように、本発明に係る体温上昇飲食品用の剤は、すぐれた基礎体温上昇作用を有し、これと共に、基礎代謝を高くし、日常生活での消費エネルギーを上昇させることから、体脂肪の燃焼が図られ、その結果、体脂肪蓄積の低下や冷え性の改善にも有効である。   As will be apparent from the examples described later, the agent for increasing body temperature food and drink according to the present invention has an excellent basal body temperature increasing action, and at the same time, increases basal metabolism and increases energy consumption in daily life. Therefore, body fat can be burned, and as a result, it is also effective in reducing body fat accumulation and improving coldness.

本発明に係る体温上昇飲食品用の剤は、極めて有効な体温上昇作用を有し、その使用にあたっては、粉末のまま使用するほか、前述の通り溶液、特に水溶液として使用しても良く、この場合には本発明の組成物をそのまま水に溶解して溶液を調製しても、あるいは個々のアミノ酸を別個に水に溶解して溶液中で前述の組成を実現しても良い。
以下、本発明の実施例について述べる。
The agent for increasing body temperature food or drink according to the present invention has a very effective body temperature increasing action, and in use thereof, in addition to being used as a powder, it may be used as a solution, particularly as an aqueous solution as described above. In some cases, the composition of the present invention may be dissolved in water as it is to prepare a solution, or individual amino acids may be dissolved separately in water to achieve the above-described composition in the solution.
Examples of the present invention will be described below.

(1)方法
8〜10週齢のSD系雄性ラットを6匹1群として6群用意し、一夜絶食した後、実験に使用した。なお、群分けは、使用日当日の体重によって行った。
(1) Method Six groups of 8 to 10-week-old SD male rats were prepared as a group, and after fasting overnight, they were used for experiments. The grouping was performed according to the body weight on the day of use.

(2)被験物質
被験物質としては、4種アミノ酸(チロシン、アスパラギン酸、グルタミン酸、アラニン)及び1種アミノ酸(チロシン)を使用した。配合割合は表1に示したとおりであるが、4種アミノ酸の配合については、配合割合を次の表2のように決定し、1種アミノ酸(チロシン)については、4種アミノ酸の配合割合に基づいて決定した。なお、アミノ酸は、いずれも和光純薬工業(株)より入手した。
(2) Test substance Four kinds of amino acids (tyrosine, aspartic acid, glutamic acid, alanine) and one kind of amino acid (tyrosine) were used as test substances. The blending ratio is as shown in Table 1, but for the blending of four amino acids, the blending ratio is determined as shown in Table 2 below, and for one amino acid (tyrosine), the blending ratio of the four amino acids is set. Decided on the basis. All amino acids were obtained from Wako Pure Chemical Industries.

Figure 2009159984
Figure 2009159984

(3)投与量
1群をコントロール(注射用水)とした。2群に対しては、4種アミノ酸を0.5g/体重100gあたり(5g/kg)を1回経口投与した。3〜5群は1種アミノ酸投与群とし、3群に対してはチロシンを0.25g/体重100gあたり(2.5g/kg)、同じく4群に対してはチロシンを0.125g/体重100gあたり(1.25g/kg)、同じく5群に対してはチロシンを0.0625g/体重100gあたり(0.625g/kg)の各用量で1回経口投与した。なお、3〜5群についてはコントロール(注射用水)をもう1群用意し、試験を行った。
(3) Dose One group was used as a control (water for injection). For group 2, four amino acids were orally administered once per 0.5 g / 100 g body weight (5 g / kg). Groups 3 to 5 are groups administered with one amino acid, tyrosine is 0.25 g / 100 g body weight (2.5 g / kg) for group 3, and tyrosine is 0.125 g / 100 g body weight for group 4. Per group (1.25 g / kg), and for 5 groups, tyrosine was orally administered once at each dose of 0.0625 g / 100 g body weight (0.625 g / kg). For groups 3 to 5, another group of controls (water for injection) was prepared and tested.

なお、被験物質アミノ酸は生理食塩水に懸濁し、コントロールには生理食塩液(光製薬(株)、日本薬局方生理食塩液、Lot.9911HC)のみを投与した。   The test substance amino acid was suspended in physiological saline, and only physiological saline (Hikari Pharmaceutical Co., Ltd., Japanese Pharmacopoeia physiological saline, Lot. 9911HC) was administered as a control.

(4)体温測定
動物はボールマンケージに入れ保定し、体温測定用のプローブは肛門から直腸に挿入し固定した。10〜15分おきに計測し、体温が安定したら被験物質を投与し摂取0分の際の温度を基準とし、のち10分おきに90分後まで体温を測定した。各群ごとに結果より平均を取りその値をグラフに示した。また、個体ごとの上昇体温の最高値を群ごとに平均し、各群間での差を示した。
(4) Body temperature measurement The animal was placed in a Ballman cage and held, and a probe for body temperature measurement was inserted into the rectum from the anus and fixed. Measurements were taken every 10-15 minutes, and when the body temperature was stabilized, the test substance was administered, and the body temperature was measured every 10 minutes until 90 minutes later, based on the temperature at the time of ingestion 0 minutes. The average was taken from the results for each group and the value was shown in the graph. Moreover, the highest value of the rising body temperature for every individual was averaged for every group, and the difference between each group was shown.

すなわち、1種アミノ酸(チロシン)の各投与量における最高体温上昇度の平均を図1に示し、各経過時間における体温上昇温度の平均及び体温の平均を、それぞれ、図2及び図3に示した。   That is, the average of the maximum body temperature rise at each dose of one amino acid (tyrosine) is shown in FIG. 1, and the average of the body temperature rise temperature and the average of the body temperature at each elapsed time are shown in FIG. 2 and FIG. 3, respectively. .

また、4種アミノ酸については、最高体温上昇度の平均を図4に示し、各経過時間における体温上昇温度の平均を図5に示した。   Moreover, about 4 types of amino acids, the average of the maximum body temperature rise degree was shown in FIG. 4, and the average of the body temperature rise temperature in each elapsed time was shown in FIG.

(5)結果及び考察
上記結果から明らかなように、対照群の温度は時間経過とともにやや上昇した。被験物質投与群(チロシン1種投与群)では、ほぼ用量依存的な体温上昇を示し、T−検定、F−検定の結果、対照群に比して2群(4種アミノ酸)で有意な差が認められた。
(5) Results and Discussion As is clear from the above results, the temperature of the control group slightly increased with time. In the test substance-administered group (group of 1 tyrosine group), there was an almost dose-dependent increase in body temperature, and as a result of T-test and F-test, a significant difference was found in 2 groups (4 amino acids) compared to the control group. Was recognized.

チロシン 2.6kg、クエン酸 1kg、ショ糖 2kg、トレハロース 1kg、香料 1kg、水 92.4kgを加熱溶解混合し、体温上昇性アミノ酸含有液を製造した。これを一回分200mlづつビン詰め、殺菌し、体温上昇性アミノ酸含有ドリンク剤とした。   2.6 kg of tyrosine, 1 kg of citric acid, 2 kg of sucrose, 1 kg of trehalose, 1 kg of fragrance, 92.4 kg of water were heated and dissolved and mixed to produce a body temperature-raising amino acid-containing solution. This was bottled in 200 ml portions, sterilized, and used as a drink containing amino acid containing a temperature-enhancing amino acid.

チロシン 1.3kg、アスパラギン酸 0.03kg、グルタミン酸 0.58kg、アラニン0.67kg、クエン酸 1kg、ショ糖 2kg、トレハロース 1kg、香料 1kg、水 92.42kgを加熱溶解混合し、体温上昇性アミノ酸含有液を製造した。これを一回分200mlづつビン詰め、殺菌し、体温上昇性アミノ酸含有ドリンク剤とした。   1.3 kg of tyrosine, 0.03 kg of aspartic acid, 0.58 kg of glutamic acid, 0.67 kg of alanine, 1 kg of citric acid, 2 kg of sucrose, 1 kg of trehalose, 1 kg of fragrance and 92.42 kg of water are mixed by heating. A liquid was produced. This was bottled in 200 ml portions, sterilized, and used as a drink containing amino acid containing a temperature-enhancing amino acid.

Claims (6)

アミノ酸としてチロシンのみを有効成分として含有すること、を特徴とする体温上昇飲食品用の剤。   An agent for foods and drinks for raising body temperature, characterized by containing only tyrosine as an active ingredient as an amino acid. アミノ酸として、チロシン、アスパラギン酸、グルタミン酸、アラニンの4種アミノ酸のみを有効成分として含有すること、を特徴とする体温上昇飲食品用の剤。   An agent for increasing body temperature food or drink characterized by containing, as amino acids, only four kinds of amino acids tyrosine, aspartic acid, glutamic acid, and alanine as active ingredients. チロシンを200ml当り25mg以上含有すること、を特徴とする請求項1又は2に記載の剤。   The agent according to claim 1 or 2, which contains 25 mg or more of tyrosine per 200 ml. チロシンを該アミノ酸群中45(重量)%以上含有すること、を特徴とする請求項2又は3に記載の剤。   The agent according to claim 2 or 3, wherein tyrosine is contained in the amino acid group in an amount of 45% (by weight) or more. 請求項1〜4のいずれか1項に記載の有効成分と飲食品用に常用される添加料のみからなること、を特徴とする体温上昇飲食品用の剤。   The agent for body temperature rise food-drinks characterized by consisting only of the active ingredient of any one of Claims 1-4, and the additive normally used for food-drinks. 請求項1〜4のいずれか1項に記載の剤を含有すること、を特徴とする体温上昇飲食品。   A body temperature increasing food or drink comprising the agent according to any one of claims 1 to 4.
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JP2021096760A (en) * 2019-12-19 2021-06-24 株式会社キムラタン Watching system, watching device, watching method, and watching program
JPWO2020045612A1 (en) * 2018-08-31 2021-08-12 味の素株式会社 Intermittent endurance improver or blood pH raiser

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WO2001093696A1 (en) * 2000-06-02 2001-12-13 Ikeda Food Research Co., Ltd. PROCESS FOR PRODUCING FERMENTED FOODS RICH IN η-AMINOBUTYRIC ACID AND FREE AMINO ACIDS
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JPS6410950A (en) * 1987-07-02 1989-01-13 Sanwa Kagaku Kenkyusho Co Elimination of taste and odor of substance rich in amino acid
JP2000270841A (en) * 1999-03-29 2000-10-03 Gunze Ltd Production of amino acid-rich ang-khak
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JPWO2020045612A1 (en) * 2018-08-31 2021-08-12 味の素株式会社 Intermittent endurance improver or blood pH raiser
JP7264169B2 (en) 2018-08-31 2023-04-25 味の素株式会社 Intermittent endurance improver or blood pH raiser
JP2021096760A (en) * 2019-12-19 2021-06-24 株式会社キムラタン Watching system, watching device, watching method, and watching program

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