JP2009157028A - Cytoscopy education support system, central device, terminal unit and computer program - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cytoscopy education support system capable of improving the cell classification ability of a tester who performs cytoscopy, without having an instructor spend much time teaching, a central device, a terminal unit and a computer program. <P>SOLUTION: In the plurality of terminal units, a cell image identified by identification information is displayed, and the input of the classification information of the displayed cell image is received. The received classification information and the identification information of the corresponding cell image are transmitted to the central device. The central device receives the identification information and the classification information from many terminal units, sums up the two or more pieces of received classification information for each identification information, and generates and stores summed-up result information. The user of the terminal unit acquires the summed-up result information at various timings, compares the information with own classification information and refers to the information. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a cell test education support system, a central device, a terminal device, and a computer program that enable an inspector performing a cell test to improve classification counting technology.

  When examining blood cells, tissue cells used in pathological examinations, etc., the so-called `` microscopic examination '' is performed in which a smear prepared by placing the cells to be examined on a preparation is visually inspected with a microscope. Is well done. In microscopic examination, for example, when examining blood cells through a dedicated classification counter equipped with a keyboard in which cell classification item names are assigned to each key while looking through the smear with a microscope, Perform a classification count of white blood cells present in the region. When morphological abnormalities such as red blood cells and platelets and cells (white blood cells) that are difficult to judge classification items are found during the classification count, the target cells are imaged with a video camera or the like equipped with a microscope.

  The captured cell image is stored in the database of the image filing system in association with the attribute information to be examined, for example, the chart number. After the inspection is completed, the result of classification count is printed, and the stored cell image is printed as necessary to obtain the inspection result.

  However, in the above-described method, since the smear is looked into with a microscope and visually inspected, the inspector needs to perform inspection at the place where the microscope is installed. For this reason, there is a problem that the inspector is restricted by location.

  Therefore, in order to eliminate such a place restriction, for example, in Patent Document 1, a virtual slide in which a sample for pathological cytodiagnosis is imaged by a video camera or the like provided in a microscope is created, and a cell image in the virtual slide is created. A technique for performing a classification count operation is disclosed. In Patent Document 1, it is possible to observe a virtual slide with a computer in which a predetermined program is installed by distributing the virtual slide via the Internet. Therefore, the inspector does not need to perform the inspection at the place where the microscope is installed, and can execute the inspection using the virtual slide without being restricted by the location.

For example, Patent Document 2 discloses a technique in which cell images to be classified and counted are specified in advance, and cell images to be targeted are sequentially selected by a predetermined key operation. Thereby, the classification count operation can be performed for each selected cell image.
JP-A-2005-283418 JP 2006-105695 A

  In medical institutions nationwide, the number of staff in the testing department tends to be reduced, so if a staff in charge of cytology is newly assigned, the know-how of cytology can be transferred to the new staff There was a limit to the number of staff themselves. In addition, even when there are staff members, there is a problem that it is difficult to devote time to staff training because it is necessary to perform inspection work with a small number of people.

 Patent Document 1 describes that an inspecting doctor instructs an inspection engineer based on a virtual slide classification count result received via a network. Patent Document 2 describes that the instructor confirms the result of the classifier counting by the instructor using the virtual slide. However, even when the techniques described in Patent Documents 1 and 2 are used, it is still necessary for the instructor to take time to instruct the instructor, and the above problem that the instructor is insufficient It does not solve.

  The present invention has been made in view of such circumstances, and a cell inspection education support system that can improve the cell classification ability of an inspector who performs a cell inspection without taking much time for instruction by the instructor. An object is to provide a central device, a terminal device, and a computer program.

  In order to achieve the above object, the cytological test education support system according to the first aspect of the present invention is connected so that data communication can be performed between a plurality of terminal devices and a central device that collects classification information received by the plurality of terminal devices. In the cell examination education support system, the terminal device displays cell image display means for displaying a cell image identified by the identification information, and inputs classification information of the cell image displayed by the cell image display means. Classification information reception means for receiving, classification information transmission means for transmitting the received classification information and the corresponding identification information of the cell image to the central device, the central device comprising the identification information and the classification information A classification information receiving unit that receives the classification information, and a classification information totaling unit that generates the totaling result information by totaling the plurality of received classification information for each identification information. Characterized in that it obtain.

  Further, in the cell examination education support system according to the second invention, in the first invention, the cell image display means corresponds to identification information for identifying each cell image and position information indicating a position of each cell image on the image. The attached cell image information, and the terminal device receives a selection of a predetermined cell image, a position information acquisition unit that acquires the position information of the cell image that has received the selection, and the acquisition Identification information specifying means for specifying identification information of the cell image based on the positional information, and the classification information receiving means receives the classification information of the cell image corresponding to the specified identification information. And

  Further, in the cell examination education support system according to the third invention, in the first or second invention, the cell image display means displays the cell image and another cell image existing within a predetermined range around the cell image. It is characterized by displaying a specimen image including it.

  Next, in order to achieve the above object, the central device according to the fourth aspect of the present invention is a central device connected so as to be able to perform data communication with a plurality of terminal devices. Classification information receiving means for receiving information and identification information for identifying the cell image corresponding to the classification information, and a classification for generating aggregate result information by totaling the plurality of received classification information for each identification information And an information counting means.

  Next, in order to achieve the above object, a terminal device according to a fifth aspect of the present invention is a cell image that displays a cell image identified by identification information in a terminal device connected so as to be capable of data communication with a central device. Display means, classification information receiving means for receiving input of classification information of the cell image displayed by the cell image display means, and aggregation result information obtained by aggregating a plurality of the classification information for each identification information in the central device And a totaling result information display unit capable of displaying and outputting the totaling result information received together with the classification information.

  In the terminal device according to a sixth aspect based on the fifth aspect, the cell image display means is associated with identification information for identifying each cell image and position information indicating the position of each cell image on the image. Cell image selection means for displaying selected cell image information, position information acquisition means for acquiring position information of the cell image that has received the selection, and the position information acquisition means based on the acquired position information An identification information specifying unit that specifies identification information of the cell image, wherein the classification information receiving unit receives the classification information of the cell image corresponding to the specified identification information.

  In the terminal device according to a seventh aspect based on the sixth aspect, the cell image display means displays a sample image including the cell image and another cell image existing within a predetermined range around the cell image. It is characterized by that.

  The terminal device according to an eighth invention is characterized in that, in the sixth or seventh invention, the tabulation result information display means displays and outputs the tabulation result information corresponding to the selected cell image.

  The terminal device according to a ninth aspect of the invention is the terminal device according to the eighth aspect of the invention, further comprising: an extracting unit that extracts an item including the received classification information from the received totaling result information, and the totaling result information display unit Is characterized in that the format for displaying and outputting items corresponding to the classification information extracted by the extracting means is changed.

  Next, in order to achieve the above object, a computer program according to a tenth aspect of the present invention is a computer program that can be executed by a central device that is connected to be capable of data communication with a plurality of terminal devices. A classification information receiving means for receiving the classification information of the cell image received by the terminal device and the identification information for identifying the cell image corresponding to the classification information, and the received plurality of classification information It is made to function as a classification information totaling means which totals every identification information and produces | generates total result information.

  Next, in order to achieve the above object, a computer program according to an eleventh aspect of the present invention is a computer program that can be executed by a terminal device connected so as to be able to perform data communication with a central device. A cell image display means for displaying a cell image identified by the identification information, a classification information reception means for receiving input of classification information of the cell image displayed by the cell image display means, and a plurality of the classifications in the central device A totaling result information receiving unit that receives totaling result information obtained by totaling information for each identification information, and a totaling result information display unit that can display and output the received totaling result information together with the classification information. It is characterized by.

  Next, in order to achieve the above object, a terminal device according to a twelfth aspect of the present invention includes a cell image display unit that displays a cell image identified by identification information, and a cell image display unit that displays the cell image displayed by the cell image display unit. Classification information reception means for receiving input of one classification information, aggregation result information storage means for storing aggregation result information generated by aggregating a plurality of second classification information for each identification information, and the received first And a totaling result information display means capable of displaying and outputting both the classification information and the stored totaling result information.

  Next, in order to achieve the above object, a computer program according to a thirteenth aspect of the present invention is a computer program that can be executed by a terminal device, wherein the terminal device displays a cell image that is identified by identification information. Display means, classification information receiving means for receiving input of the first classification information of the cell image displayed by the cell image display means, and a counting result generated by counting a plurality of second classification information for each identification information And a totaling result information storage unit for storing information, and a totaling result information display unit capable of displaying and outputting both the received first classification information and the stored totaling result information. .

  In the first invention, the fourth invention, and the tenth invention, the central device receives the identification information of the cell image and the classification information for the received cell information, and aggregates the received plurality of classification information for each identification information. Generate information. As a result, inspectors or students who are inexperienced in testing ability can improve the inspection technology without receiving guidance from the instructor by comparing this total result information with their classification information. It becomes possible. Furthermore, if the cells that are subject to aggregation are cells that can be judged even by an expert, it is possible to determine which one by referring to the aggregation result information obtained based on a lot of classification information. It becomes possible to support the final decision on whether to classify cells.

  Here, “cell image” means an image showing one cell to be classified. “Identification information” means identification information such as an ID for distinguishing cell images. “Category information” means information related to a classification category, a classification item, and the like for a predetermined cell image. “Aggregation result information” refers to information on the number of times, frequency, etc., classified for each classification item, etc., by summarizing the classification information input by a plurality of examiners for each identification information for identifying cell images. Means the information compiled as

  In 5th invention and 11th invention, a terminal device displays the cell image identified by identification information, and receives the input of the classification information of the displayed cell image. Aggregation result information obtained by aggregating a plurality of classification information for each identification information is received from the central apparatus, and the received aggregation result information is displayed and output together with the classification information. As a result, inspectors or students who are inexperienced in testing ability can improve the inspection technology without receiving guidance from the instructor by comparing this total result information with their classification information. It becomes possible. Furthermore, if the cells that are subject to aggregation are cells that can be judged even by an expert, it is possible to determine which one by referring to the aggregation result information obtained based on a lot of classification information. It becomes possible to support the final decision on whether to classify cells.

  In the second invention and the sixth invention, the terminal device displays identification information for identifying each cell image and cell image information associated with position information indicating the position of each cell image on the image. Then, selection of a predetermined cell image is received, and position information of the cell image that has received the selection is acquired. Based on the acquired position information, identification information of the cell image is specified, and classification information of the cell image corresponding to the specified identification information is received. Thereby, even when a plurality of cell images are displayed on one screen, classification information can be input by selecting a cell image to be classified. “Position information” means position information on a cell image, for example, a coordinate value. “Cell image information” means an aggregate of image data related to a plurality of cell images, which is image data associated with at least identification information related to a cell count to be classified and position information.

  In the third and seventh inventions, the terminal device displays a sample image including a cell image and other cell images existing within a predetermined range around the cell image. When a cell image is classified, it is often affected by the state of cells existing around the target cell image, and the cell image and a predetermined range around the cell image (in a range narrower than the entire virtual slide). Yes, for example, by displaying a specimen image including other cell images existing on one screen), it is possible to confirm a comprehensive judgment result. The “specimen image” means an image within a predetermined range including a cell image to be classified and a cell image existing around the cell image.

  In the eighth invention, the terminal device displays and outputs the total result information corresponding to the selected cell image. As a result, it is possible to easily confirm to which cell image the displayed and totaled result information is the information.

  In the ninth invention, the terminal device extracts an item including the received classification information from the received aggregation result information, and changes the format for displaying and outputting the extracted item. As a result, the inspector can easily visually compare the results classified by himself / herself with the results classified by a plurality of inspectors, and whether his / her judgment is consistent with many other inspectors. It becomes possible to confirm.

  In the twelfth and thirteenth inventions, the cell image identified by the identification information is displayed, and the input of the first classification information of the displayed cell image is accepted. By storing the aggregation result information generated by aggregating a plurality of second classification information for each identification information, and displaying and outputting both the received first classification information and the stored aggregation result information, For inspectors or students who are inexperienced in testing ability, it is possible to improve the inspection technology without receiving guidance from the instructor by comparing this tabulated result information with their own classification information. . Furthermore, if the cells that are subject to aggregation are cells that can be judged even by an expert, it is possible to determine which one by referring to the aggregation result information obtained based on a lot of classification information. It becomes possible to support the final decision on whether to classify cells.

  In the embodiment described later, the cell image display means is the process of step S302, step S702 and step S1601 of the CPU 21 of the terminal device 2, and the classification information reception means is the process of step S303, step S706 and step S1602 of the CPU 21. The process corresponds to the classification information transmitting means, which corresponds to the processes of step S304 and step S707 of the CPU 21, respectively. On the other hand, the classification information receiving means corresponds to the processing of steps S305 and S708 of the CPU 31 of the central apparatus 3, and the classification information aggregation means corresponds to the processing of steps S306 and S709 of the CPU 31, respectively.

  The cell image selection means corresponds to the process of step S703 of the CPU 21, the position information acquisition means corresponds to the process of step S704 of the CPU 21, and the identification information specifying means corresponds to the process of step S705 of the CPU 21. Further, the totaling result information receiving unit corresponds to the processing of step S1002 of the CPU 21 of the terminal device 2, and the totaling result information display unit corresponds to the processing of step 1003 and step S1604 of the CPU 21, respectively.

  According to the above configuration, inspectors or students who are inexperienced in testing ability can improve the inspection technology without receiving guidance from the leader by comparing this total result information with their classification information. It becomes possible to plan. Furthermore, if the cells that are subject to aggregation are cells that can be judged even by an expert, it is possible to determine which one by referring to the aggregation result information obtained based on a lot of classification information. It becomes possible to support the final decision on whether to classify cells.

  Hereinafter, a cytological test education support system according to an embodiment of the present invention will be described in detail based on the drawings, taking as an example the case of executing a blood morphology survey.

(Embodiment 1)
FIG. 1 is a block diagram showing a configuration of a cell test education support system according to Embodiment 1 of the present invention. As shown in FIG. 1, the cytological test education support system according to the first embodiment includes a central device 3 and a plurality of terminal devices 2, 2,... Via a network 1 represented by the Internet. It is connected so that it can send and receive data.

  The central device 3 includes at least a CPU (central processing unit) 31, a ROM 32, a RAM 33, a storage device 34, an input device 35, a display device 36, an auxiliary storage device 37, a communication device 38, and an internal bus 39 for connecting the hardware described above. It consists of The CPU 31 is connected to the above-described hardware units of the central device 3 via the internal bus 39, controls the operation of the above-described hardware units, and follows the computer program 100 stored in the storage device 34. Perform various software functions. The RAM 33 is configured by an SRAM, a flash memory, and the like. The load module is expanded when the computer program 100 is executed, and temporary data generated when the computer program 100 is executed is stored. Of course, the computer program 100 may be stored in the ROM 32 in advance.

  The storage device 34 is configured by a built-in fixed storage device (hard disk) or the like. The computer program 100 stored in the storage device 34 is downloaded by the auxiliary storage device 37 from a portable recording medium 90 such as a DVD or CD-ROM in which information such as programs and data is recorded, and from the storage device 34 at the time of execution. The data is loaded into the RAM 33 and executed. Of course, a computer program downloaded from an external computer via the communication device 38 may be used.

  In addition, the storage device 34 includes a totaling result information storage unit 341. The tabulation result information storage unit 341 tabulates the results classified by the surveyor executing the survey in the plurality of terminal devices 2, 2,... For each cell identification information, and associates the results with the cell image identification information. And remember.

  The communication device 38 is connected to an internal bus 39, and is connected to an external network 1 such as the Internet, a LAN, or a WAN, so that data can be transmitted / received to / from an external computer or the like. That is, the storage device 34 described above is not limited to the configuration built in the central device 3, and may be an external recording medium such as an external storage connected via the communication device 38.

  The input device 35 is a data input medium such as a keyboard and a mouse. The display device 36 is a display device such as a CRT monitor or LCD.

  In the first embodiment, a computer provided with a display device capable of displaying a cell image (specimen image) as the terminal device 2 will be described as an example. FIG. 2 is a block diagram showing a configuration of the terminal device 2 used in the cell test education support system according to Embodiment 1 of the present invention. As shown in FIG. 2, the terminal device 2 includes at least a CPU (Central Processing Unit) 21, a RAM 22, a storage device 23, an input device 24, a display device 25, an output device 26, a communication device 27, an auxiliary storage device 28, and the above-described device. The internal bus 29 is connected to the hardware. The CPU 21 is connected to the above-described hardware units of the terminal device 2 via the internal bus 29, controls the operation of the above-described hardware units, and follows the computer program 101 stored in the storage device 23. Perform various software functions. The RAM 22 includes an SRAM, a flash memory, and the like. The load module is expanded when the computer program 101 is executed, and stores temporary data generated when the computer program 101 is executed.

  The storage device 23 is configured by a built-in fixed storage device (hard disk) or the like. The computer program 101 stored in the storage device 23 is downloaded by the auxiliary storage device 28 from a portable recording medium 91 such as a DVD or CD-ROM in which information such as programs and data is recorded, and from the storage device 23 at the time of execution. The program is expanded into the RAM 22 and executed. Of course, a computer program downloaded from an external computer via the communication device 27 may be used.

  The storage device 23 includes a classification information storage unit 231. The classification information storage unit 231 stores the result of classification by the surveyor executing the survey in the terminal device 2 in association with the identification information of the cell image.

  The input device 24 is a data input medium such as a keyboard and a mouse. The display device 25 is a display device such as a CRT monitor or LCD, and displays information related to the result determination graphically. The output device 26 is a printing device such as a laser printer or an inkjet printer.

  Processing procedures in the terminal device 2 and the central device 3 in the cytological test education support system having the above-described configuration will be described. FIG. 3 is a flowchart showing the processing procedure of the CPU 21 of the terminal device 2 and the CPU 31 of the central device 3 used in the cytological test education support system according to Embodiment 1 of the present invention.

  In FIG. 3, the CPU 21 of the terminal device 2 receives the display data related to the cell image from the central device 3 (step S301), and displays the received display data related to the cell image on the display device 25 (step S302). “Display data relating to cell images” includes cell image data which is image data and at least identification information for identifying cell images. The identification information includes ID information for identifying a cell image to be classified and counted, and a cell identification number assigned with a serial number starting from the upper left corner of the entire specimen image including the cell image and other cell images existing around it The information is not particularly limited as long as the information can distinguish the cell image. Further, the display data relating to the cell image is not limited to being received via the network 1, and data distributed via a portable recording medium such as a CD or a DVD may be used.

  Note that the image displayed on the display device 25 of the terminal device 2 is displayed as a sample image including a cell image of a cell to be classified and a cell image of another cell existing within a predetermined range around the cell image. It is preferable to do. This is because, in the cell ecology survey, the judgment of classification items often varies depending on the situation of cells around the cells to be classified and counted.

  The CPU 21 of the terminal device 2 accepts input of cell image classification information (step S303). The method for selecting the cell image is not limited to the method for selecting with the input device 24 such as a mouse. For example, a method of changing a cell image to be selected by providing a cell identification number as identification information and providing a button for operating the cell identification number may be used.

  The classification information is information related to classification categories and classification items for a predetermined cell image, and the classification counting process is to identify each classification category and classification item to which each cell image corresponds. The process of counting the number of cells belonging to a classification item or the like. The surveyor inputs its own classification judgment for the given cell image, for example, via the input device 24.

  The received classification information is preferably stored in the classification information storage unit 231 of the storage device 23 in association with the identification information of the cell image. This is because it can be easily compared with the total result information (details will be described later) received from the central device 3.

  FIG. 4 is an exemplary diagram of a data configuration stored in the classification information storage unit 231. In the example of FIG. 4, the cell identification number is used as the identification information of the cell image to be classified and the classification item name received from the surveyor is stored for each cell identification number.

  Returning to FIG. 3, the CPU 21 of the terminal device 2 transmits the received classification information and the identification information of the corresponding cell image to the central device 3 together with the surveyor identification information for identifying the surveyor (step S304). In this way, a plurality of surveyors execute the classification counting process for the same virtual slide, and the determination results are collected in the central device 3. The surveyer identification information is not particularly limited as long as it is information that can identify the surveyor. For example, it may be account information of the surveyor who logs in to the terminal device 2 or the terminal of the terminal device 2. ID may be sufficient.

  The CPU 31 of the central device 3 receives the identification information and the classification information from the terminal device 2 together with the surveyor identification information (step S305), and aggregates the received plurality of classification information for each identification information to generate the total result information ( Step S306). Here, the total result information is information about the number of times, the frequency, etc. classified into the classification items, for each classification information, etc., by adding the classification information input by a plurality of surveyors for each identification information for identifying cell images. It means the information compiled as.

  The central device 3 stores the generated total result information in the total result information storage unit 341 of the storage device 34 (step S307). By providing the counting result information storage unit 341, the classification information received from the plurality of terminal devices 2 can be reflected in the counting result information in substantially real time, and the validity of own judgment can be improved based on the latest situation. Judgment can be made.

  FIG. 5 is an exemplary diagram of a data configuration stored in the total result information storage unit 341. In the example of FIG. 5, the cell identification number is used as the identification information of the cell image that is the target of the classification count. For each cell identification number, the cumulative value of the frequency distribution of the classified classification items is stored.

  As the total result information storage unit 341, the cumulative value of the frequency distribution may be stored as in the example of FIG. 5, or may be stored as a result of calculating the classification frequency. FIG. 6 is an exemplary diagram of a data configuration when the classification frequency is stored in the total result information storage unit 341.

  In the example of FIG. 6 as well, the cell identification number is used as the identification information of the cell image that is the target of the classification count. Then, the ratio of the classified classification items is calculated and stored for each cell identification number. By transmitting to the terminal device 2 in such an organized state, the processing load on the terminal device 2 can be reduced, and comparison with the classification item name input by the surveyor can be easily performed. .

  In this way, the results of classification work performed by many examiners on the same cell image can be aggregated. It is possible to support making a final decision with reference to the classification information. In addition, for an unskilled person, a student, or the like, the judgment of an expert can be referred to based on the total result information, and the inspection technique can be improved by comparing the information with his / her classification information.

  Note that, as in the above-described example, the present invention is not limited to accepting the classification information by associating the cell image with the identification information and displaying the image one by one, and displaying the data of the entire virtual slide as the cell image information. Classification information may be accepted. FIG. 7 is a flowchart showing processing procedures of the CPU 21 of the terminal device 2 and the CPU 31 of the central device 3 when receiving cell image information.

  In FIG. 7, the CPU 21 of the terminal device 2 receives the cell image information from the central device 3 (step S701), and displays the received cell image information on the display device 25 (step S702). “Cell image information” is a collection of image data related to a plurality of cell images, which is image data associated with at least identification information related to a cell image to be classified and position information. As the identification information, it is possible to distinguish cell images such as ID information for identifying a cell image to be classified and counted, an identification number assigned a serial number starting from the upper left corner of the entire virtual slide including the cell image, and the like. If it is information, it will not specifically limit. The cell image information is not limited to being received via the network 1, and data distributed via a portable recording medium such as a CD or a DVD may be used.

  The position information is information indicating in which position of the virtual slide the cell image data that is image data exists. For example, create a virtual slide in which a cytodiagnosis sample is imaged with a video camera equipped with a microscope, etc., and represent the coordinate value with the upper left corner of the virtual slide as the origin, the right direction as the x axis, and the lower direction as the y axis Can do. FIG. 8 is an exemplary diagram schematically showing a method for specifying position information.

From the origin O at the upper left corner, a coordinate axis is defined with the x axis having the right direction as the positive direction and the y axis having the lower direction as the positive direction so as to include the cell existence area 81 of the virtual slide. Then, the coordinate value P (x _p , y _p ) of the upper left corner of the image area 82 displayed on the display device 25 of the terminal device 2 is acquired from the screen scroll information. On the other hand, the coordinate value Q (x _q , y _q ) on the display screen at the center of the cell image region 83 to be classified and counted is acquired via the input device 24 such as a mouse. In this way, the coordinate value Q indicating the center of the cell image region 83 can be obtained as Q (x _p + x _q , y _p + y _q ) which is an absolute coordinate value indicating the position in the entire virtual slide. . Then, by specifying the sizes of the cell image region 83 in the x-axis direction and the y-axis direction, the absolute coordinate values on the virtual slide of the cell image region 83 selected on the screen can be obtained.

  The identification information and the position information are stored in the storage device 34 of the central device 3 for each cell image when creating a virtual slide. For example, the absolute coordinate value of the center of the cell image region 83 is stored as the position information in association with the identification information of the cell image. FIG. 9 is an exemplary diagram of a data configuration stored in the storage device 34.

  As shown in FIG. 9, for each cell identification number for identifying a cell image, the center coordinate value of the cell image region 83 and the sizes in the x-axis direction and the y-axis direction are stored together with the cell image data name to be displayed. deep. When the cell image displayed on the screen is selected via the input device 24 such as a mouse, the coordinate value of the center of the cell image region 83 including the cell image to be classified and counted is the coordinate on the screen. Get as value. Based on the absolute coordinate value of the upper left corner of the image area 82 corresponding to the displayed screen and the coordinate value of the center of the acquired cell image area 83, the center coordinate value of the selected cell image area 83 is calculated. By querying the storage device 34, the cell identification number of the selected cell image can be specified.

  In addition, in the image displayed on the display device 25 of the terminal device 2, a cell image of a cell to be classified and another cell image existing within a predetermined range around the cell image are displayed as a sample image. It is preferable to do. This is because, in the cell ecology survey, the judgment of classification items often varies depending on the situation of cells around the cells to be classified and counted.

  Returning to FIG. 7, the CPU 21 of the terminal device 2 accepts selection of a predetermined cell image from the displayed cell images (step S703), and acquires position information of the selected cell image (step S704). . Specifically, the position information of the selected cell image is calculated by clicking the cell image in the image with the input device 24 such as a mouse and executing the above-described calculation. The CPU 21 specifies identification information from the received cell image information based on the calculated position information (step S705), and accepts input of cell image classification information (step S706). The method for selecting the cell image is not limited to the method for selecting with the input device 24 such as a mouse. For example, a method of changing a cell image to be selected by providing a cell identification number as identification information and providing a button for operating the cell identification number may be used.

  The received classification information is preferably stored in the classification information storage unit 231 of the storage device 23 in association with the identification information of the cell image. This is because it can be easily compared with the total result information received from the central device 3. Since the data configuration stored in the classification information storage unit 231 is the same as that shown in FIG. 5, a detailed description thereof will be omitted. Note that an absolute coordinate value indicating the center of the cell image region 83 may be stored in association with the position information of the cell image. This is to improve the response by reducing the number of databases to be referred to.

  Returning to FIG. 7, the CPU 21 of the terminal device 2 transmits the received classification information and identification information of the corresponding cell image to the central device 3 together with the surveyor identification information for identifying the surveyor (step S707). In this way, a plurality of surveyors execute the classification counting process for the same virtual slide, and the determination results are collected in the central device 3. The surveyer identification information is not particularly limited as long as it is information that can identify the surveyor. For example, it may be account information of the surveyor who logs in to the terminal device 2 or the terminal of the terminal device 2. ID may be sufficient.

  The CPU 31 of the central device 3 receives the identification information and the classification information from the terminal device 2 together with the surveyor identification information (step S708), and aggregates the received plurality of classification information for each identification information to generate the aggregation result information ( Step S709). The central device 3 stores the generated total result information in the total result information storage unit 341 of the storage device 34 (step S710). By providing the counting result information storage unit 341, the classification information received from the plurality of terminal devices 2 can be reflected in the counting result information in substantially real time, and the validity of own judgment can be improved based on the latest situation. Judgment can be made. Since the data configuration stored in the total result information storage unit 341 is the same as that shown in FIGS. 5 and 6, detailed description thereof is omitted.

  The surveyor can determine whether or not his / her judgment is appropriate by comparing the total result information stored in the total result information storage unit 341 with the result of his / her classification. FIG. 10 is a flowchart showing a display processing procedure of the total result information of the CPU 31 of the central device 3 and the CPU 21 of the terminal device 2 according to Embodiment 1 of the present invention.

  In FIG. 10, each time the CPU 31 of the central device 3 receives the classification information from the terminal device 2, the CPU 31 of the central device 3 transmits the stored total result information to the terminal device 2 (step S <b> 1001). The CPU 21 of the terminal device 2 receives the aggregation result information (step S1002), and displays and outputs the received aggregation result information to the display device 25 together with the stored classification information (step S1003).

  FIG. 11 is an exemplary view of a display screen on the display device 25. In FIG. 11, an image area that is a part of the virtual slide is displayed on the screen, and the cell image 111 that has been selected via the input device 24 such as a mouse is displayed. A cell region 112 including the cell image 111 is displayed, and the classification result for the cell region 112 is displayed in the classification input display region 113. On the other hand, as the count result information, the number of times the cell image is classified and counted for each classification item and the overall frequency are displayed in the count result display area 114. Thereby, it is possible to easily confirm whether or not the classification item name classified by the surveyor itself is consistent with many other surveyors.

  Further, the CPU 21 may extract items including the received classification information from the received total result information. For example, in the example of FIG. 11, the classification item name “Myelo” classified by the surveyor is extracted. Then, a format for displaying and outputting the classification item name “Myelo” corresponding to the extracted classification information as the aggregation result information, for example, a display color, a display font, and the like is changed.

  Specifically, other classification item names “Promyelo” and “Meta” that do not match the classification item name classified by the surveyor are displayed in “black” including the frequency and frequency, whereas the classification item name The name “Myelo” is displayed in “red” including the frequency and frequency. By doing this, it is possible to check at a glance where the survey and its classification result belong in the total result information, for example, whether it was the most frequent item, whether it was the most frequent item, etc. It becomes possible.

  In the embodiment described above, when the total result information is displayed on the display device 25 of the terminal device 2, the total result information corresponding to the identification information of the target cell image is displayed every time the classification information is received. Of course, at the time when the classification count processing is completed for all the cell images to be classified and included in the virtual slide, the total result information may be displayed. FIG. 12 is a flowchart illustrating a processing procedure of the CPU 21 of the terminal device 2 when confirming the completion of the classification count process.

  In FIG. 12, the processes after steps S701, S702, and S707 in FIG. When cell image information is displayed (step S702), the CPU 21 of the terminal device 2 accepts selection of a predetermined cell image from the displayed cell images (step S1201), and the position of the selected cell image. Information is acquired (step S1202). Specifically, the position information of the selected cell image is calculated by clicking the cell image in the image with the input device 24 such as a mouse and executing the above-described calculation. The CPU 21 identifies identification information from the received cell image information based on the calculated position information (step S1203), and accepts input of cell image classification information (step S1204).

  The CPU 21 determines whether or not the classification information received this time has already been received (step S1205). Specifically, the determination can be made based on whether or not the information is stored in the classification information storage unit 231. When the CPU 21 determines that it has not received yet, that is, it has not been stored in the classification information storage unit 231 (step S1205: NO), the CPU 21 stores the received classification information and identification information in the classification information storage unit 231 ( Step S1206).

  When the CPU 21 determines that it has been received, that is, stored in the classification information storage unit 231 (step S1205: YES), the CPU 21 skips step S1206 and has received classification information for all identification information. Is determined (step S1207). Specifically, the identification information stored in the classification information storage unit 231 is compared with the identification information included in the cell image information.

  When the CPU 21 determines that there is identification information for which classification information has not been received yet (step S1207: NO), the CPU 21 receives selection of the next cell image (step S1208), returns the processing to step S1202, and described above. Repeat the process. When the CPU 21 determines that the classification information has been received for all the identification information (step S1207: YES), the CPU 21 advances the process to step S707.

  By doing in this way, when the input of the classification information for all the cell images subject to classification counting in the virtual slide is completed, the total result information is generated in the central device 3, and all the cell images are related. The aggregation result information can be received by the terminal device 2. In the terminal device 2, for example, by displaying the count result information in the same order as in FIG. 11 in order from the smallest cell identification number, whether the classification items classified by the surveyor itself are consistent with many other surveyors. It can be easily confirmed whether or not.

  The aggregation result information may be switched between classification levels in a plurality of hierarchies. For example, when conducting a white blood cell survey, it is not always the case that the image can be clearly displayed so that it can be classified into 'Blast (blast)', 'Myelo (myelocyte)', etc. A case where only the system 'etc. can be classified is also assumed. FIG. 13 is an exemplary diagram of classification items at the time of white blood cell classification counting. As shown in FIG. 13, classification counting may be executed in two layers, a major classification and a minor classification, according to the classification details.

  Of course, at first, the aggregation result information in the hierarchy that is the highest concept may be displayed, and the aggregation result information in the hierarchy that is the lower concept may be sequentially displayed. By doing in this way, the count result in the lowest hierarchy can be surely displayed, and it can be applied to the quality determination of the cell image as a whole.

  Even if the classification information is not input, only the total result information may be acquired and displayed. FIG. 14 is a flowchart illustrating a processing procedure of the CPU 21 of the terminal device 2 when no classification information is input.

  In FIG. 14, the processing after steps S701, S702 and S706 in FIG. 7 or the processing after step S1204 in FIG. When cell image information is displayed (step S702), the CPU 21 of the terminal device 2 accepts selection of a predetermined cell image from the displayed cell images (step S1401), and the position of the selected cell image. Information is acquired (step S1402). Specifically, the position information of the selected cell image is calculated by clicking the cell image in the image with the input device 24 such as a mouse and executing the above-described calculation. Based on the calculated position information, the CPU 21 specifies identification information from the received cell image information (step S1403), and determines whether or not request information for requesting the central apparatus 3 to transmit the total result information has been received. (Step S1404).

  The request information includes at least information indicating a transmission request for totaling result information and information for identifying the terminal device 2. In this case, the central apparatus 3 transmits count result information regarding all cell images included in the virtual slide. Further, the identification information specified in step S1403 may be included in the request information. In this case, only the aggregation result information corresponding to the identified identification information is transmitted from the central apparatus 3.

  If the CPU 21 determines that the request information has not been received (step S1404: NO), the CPU 21 proceeds to step S706 or step S1204 to execute the same processing as in FIG. 7 and FIG. Execute. When the CPU 21 determines that the request information has been received (step S1404: YES), the CPU 21 transmits the received request information to the central device 3 (step S1405), and the process proceeds to step S1002 in FIG. Execute.

  By doing this, even if the classification information is not entered, the surveyor can know the classification count result of other surveyors, and the examiner or student who classifies the cell for the first time and what form You can learn whether it is classified as a cell. And when another cell image is selected, it is also easy to accept classification information.

(Embodiment 2)
FIG. 15 is a block diagram showing a configuration of terminal apparatus 2 according to Embodiment 2 of the present invention. Unlike Embodiment 1, it is not premised on being connected with other computers such as other terminal devices 2, 2,...

  As shown in FIG. 15, the terminal device 2 includes at least a CPU (Central Processing Unit) 21, a RAM 22, a storage device 23, an input device 24, a display device 25, an output device 26, a communication device 27, an auxiliary storage device 28, and the above-described device. The internal bus 29 is connected to the hardware. The CPU 21 is connected to the above-described hardware units of the terminal device 2 via the internal bus 29, controls the operation of the above-described hardware units, and follows the computer program 102 stored in the storage device 23. Perform various software functions. The RAM 22 includes an SRAM, a flash memory, and the like. The load module is expanded when the computer program 102 is executed, and temporary data generated when the computer program 102 is executed is stored.

  The storage device 23 is configured by a built-in fixed storage device (hard disk) or the like. The computer program 102 stored in the storage device 23 is downloaded by the auxiliary storage device 28 from a portable recording medium 92 such as a DVD or CD-ROM in which information such as programs and data is recorded, and from the storage device 23 at the time of execution. The program is expanded into the RAM 22 and executed. Of course, a computer program downloaded from an external computer via the communication device 27 may be used.

  The storage device 23 includes a classification information storage unit 231 and a totaling result information storage unit 232. The classification information storage unit 231 stores the result of classification by the surveyor executing the survey in the terminal device 2 in association with the identification information of the cell image. The tabulation result information storage unit 232 tabulates the classification information (second classification information) indicating the result of the classification performed by the surveyor executing the survey in the plurality of terminal devices 2, 2,. The total result information generated in this manner is stored in association with the identification information of the cell image. The total result information is downloaded from the recorded portable recording medium 92 such as a DVD or CD-ROM by the auxiliary storage device 28. It may be downloaded from another computer via the communication device 27.

  The input device 24 is a data input medium such as a keyboard and a mouse. The display device 25 is a display device such as a CRT monitor or LCD, and displays information related to the result determination graphically. The output device 26 is a printing device such as a laser printer or an inkjet printer.

  A processing procedure in the terminal device 2 configured as described above will be described. FIG. 16 is a flowchart showing a processing procedure of the CPU 21 of the terminal device 2 according to Embodiment 2 of the present invention.

  In FIG. 16, the CPU 21 of the terminal device 2 displays the display data related to the cell image stored in advance in the storage device 23 on the display device 25 (step S1601). “Display data relating to cell images” includes cell image data which is image data and at least identification information for identifying cell images. The identification information includes ID information for identifying a cell image to be classified and counted, and a cell identification number assigned with a serial number starting from the upper left corner of the entire specimen image including the cell image and other cell images existing around it The information is not particularly limited as long as the information can distinguish the cell image. Further, the display data related to the cell image is not limited to being received from another computer via the network 1, but may be data distributed via a portable recording medium such as a CD or DVD. good.

  Note that the image displayed on the display device 25 of the terminal device 2 is displayed as a sample image including a cell image of a cell to be classified and a cell image of another cell existing within a predetermined range around the cell image. It is preferable to do. This is because, in the cell ecology survey, the judgment of classification items often varies depending on the situation of cells around the cells to be classified and counted.

  The CPU 21 of the terminal device 2 receives input of cell image classification information (first classification information) (step S1602). The method for selecting the cell image is not limited to the method for selecting with the input device 24 such as a mouse. For example, a method of changing a cell image to be selected by providing a cell identification number as identification information and providing a button for operating the cell identification number may be used.

  The classification information is information related to classification categories and classification items for a predetermined cell image, and the classification counting process is to identify each classification category and classification item to which each cell image corresponds. The process of counting the number of cells belonging to a classification item or the like. The surveyor inputs his / her classification judgment for the given cell image, for example, via the input device 24.

  The received classification information is stored in the classification information storage unit 231 of the storage device 23 in association with the identification information of the cell image. This is because the total result information stored in the total result information storage unit 232 of the storage device 23 can be easily compared. Since the data structure of the classification information stored in the classification information storage unit 231 and the data structure of the aggregation result information stored in the aggregation result information storage unit 232 are the same as those in the first embodiment, detailed description thereof is omitted. .

  The CPU 21 reads out the total result information from the total result information storage unit 232 and the classification information from the classification information storage unit 231 (step S1603), and displays and outputs the read out total result information and classification information to the display device 25 (step S1603). S1604).

  As described above, it is not limited to accepting classification information by associating cell images with identification information and displaying the images one by one. It goes without saying that classification information may be received as image information.

  As described above, according to the second embodiment, classification information (first classification information) that is input as a result of the aggregate result information distributed on the portable recording medium 92 or downloaded via the network 1. By displaying and outputting together with this, for inspectors or students who are inexperienced in testing ability, this inspection result information can be compared with their own classification information to improve inspection techniques without receiving guidance from the instructor. Can be achieved. Furthermore, if the cells that are subject to aggregation are cells that can be judged even by an expert, it is possible to determine which one by referring to the aggregation result information obtained based on a lot of classification information. It becomes possible to support the final decision on whether to classify cells.

  In addition, about the display method of total result information, it is not limited to the display method shown in Embodiment 1 and 2 mentioned above. For example, when displaying the total result information, a plurality of cell images classified as the same classification item by the surveyor may be displayed in a list for the classification item name having the largest number of responses. FIG. 17 is an exemplary diagram showing an image image when cell images are displayed as a thumbnail list.

  As illustrated in FIGS. 17A to 17F, by displaying only the cell images that the surveyor determines to be the classification item Blast, it is possible to learn the systematic determination criteria by itself.

  As shown in FIG. 17, the correct classification item name may be set in advance by a skilled person for the cell image to be classified and counted. In this case, when displaying a list of cell images, The correct classification item name may be displayed at the same time. Thereby, the surveyor can confirm at a glance whether or not his / her classification result is correct.

  Further, when the classification information is received for all the cell images to be subjected to the classification counting process, the classification item name inputted for each cell image and the correct classification item name in the display format similar to FIG. Etc. may be displayed side by side. In this case, it is determined whether or not the input classification item name matches the classification item name stored in advance as a correct answer. If there is a match, the matching classification item name is displayed in another display format, for example, a classification. By changing the color of the item name and displaying it, it is possible to make it easier to confirm the survey result of the surveyor.

  Furthermore, various variations can be set for the order of displaying the list, the pattern, and the like. For example, the surveyor himself / herself inputs the category item names displayed together, the category item names stored as correct answers are displayed together, the category item names with the most correct answers are displayed in descending order, and the most answers For example, the images are displayed in the order of the cell images that are scattered.

  Further, when the cell images displayed in a list are selected via the input device 24 such as a mouse, the surrounding cell images are scrolled by scrolling the screen so that the position of the cell image on the virtual slide becomes the center of the screen. It is preferable to display it together. This is because the situation of surrounding cell images can be confirmed at the same time, and the surveyer becomes a material for considering why it is determined that the classification item name is indicated by the total result information.

  In the example of FIG. 11, the sample image that is a part of the virtual slide, the classification item name classified by the surveyor, the classification count value as the total result information, and the like are displayed on different display areas (windows). However, when the target cell image is selected, it may be displayed in the peripheral region of the selected cell image.

  In addition, Embodiment 1 and 2 mentioned above can be changed in the range which does not deviate from the meaning of this invention, and is used not only for the blood ecology survey but for the examination accompanying various cell diagnosis, for example, pathological examination. Needless to say, education for inspectors such as tissue cell examinations can also be supported. In the first and second embodiments described above, the classification information and identification information for generating the aggregation result information are transmitted via the network. However, the central device is used by using a portable recording medium such as a CD or a DVD. Data may be input to 3.

It is a block diagram which shows the structure of the cell test | inspection education assistance system which concerns on Embodiment 1 of this invention. It is a block diagram which shows the structure of the terminal device used with the cell test | inspection education support system which concerns on Embodiment 1 of this invention. It is a flowchart which shows the process sequence of CPU of a terminal device and CPU of a central apparatus used with the cell test | inspection education support system which concerns on Embodiment 1 of this invention. It is an illustration figure of the data structure memorize | stored in a classification information storage part. It is an illustration figure of the data structure memorize | stored in a total result information storage part. It is an illustration figure of a data structure in case a classification frequency is memorize | stored in a total result information storage part. It is a flowchart which shows the process sequence of CPU of a terminal device in the case of receiving cell image information, and CPU of a central apparatus. It is an illustration figure showing the specific method of position information typically. It is an illustration figure of the data structure memorize | stored in a memory | storage device. It is an illustration figure showing the specific method of position information typically. It is a flowchart which shows the display processing procedure of the total result information of CPU of a central apparatus and CPU of a terminal device which concerns on Embodiment 1 of this invention. It is an illustration figure of the display screen in a display apparatus. It is a flowchart which shows the process sequence of CPU of a terminal device in the case of confirming completion of a classification count process. It is an illustration figure of the classification item at the time of the white blood cell classification count. It is a flowchart which shows the process sequence of CPU of a terminal device when classification information is not input. It is a block diagram which shows the structure of the terminal device which concerns on Embodiment 2 of this invention. It is a flowchart which shows the process sequence of CPU of the terminal device which concerns on Embodiment 2 of this invention. It is an illustration figure which shows the image image at the time of displaying a list of cell images like a thumbnail.

Explanation of symbols

1 Network Network 2 Terminal Device 3 Central Device 21, 31 CPU
22, 33 RAM
23, 34 Storage device 24, 35 Input device 25, 36 Display device 26 Output device 27, 38 Communication device 29, 39 Internal bus 32 ROM
28, 37 Auxiliary storage device 90, 91, 92 Portable recording medium 100, 101, 102 Computer program 231 Classification information storage unit 232, 341 Total result information storage unit

Claims (13)

A plurality of terminal devices;
In the cell test education support system connected so that data communication is possible with a central device that collects classification information received by the plurality of terminal devices,
The terminal device
Cell image display means for displaying a cell image identified by the identification information;
Classification information receiving means for receiving input of classification information of the cell image displayed by the cell image display means;
Classification information transmission means for transmitting the received classification information and the identification information of the corresponding cell image to the central device,
The central device is
Classification information receiving means for receiving the identification information and the classification information;
A cell test education support system, comprising: a classification information totaling unit that aggregates a plurality of received classification information for each identification information to generate totalization result information. The cell image display means displays identification information for identifying each cell image and cell image information associated with position information indicating the position of each cell image on the image,
The terminal device
Cell image selection means for accepting selection of a predetermined cell image;
Position information acquisition means for acquiring position information of the cell image that has received a selection;
Identification information specifying means for specifying identification information of the cell image based on the acquired position information,
The cell classification education support system according to claim 1, wherein the classification information receiving unit receives the classification information of the cell image corresponding to the identified identification information.   The cell examination education support according to claim 1 or 2, wherein the cell image display means displays a specimen image including the cell image and another cell image existing within a predetermined range around the cell image. system. In a central device connected to be able to perform data communication with a plurality of terminal devices,
Classification information receiving means for receiving the classification information of the cell image received by the terminal device and identification information for identifying the cell image corresponding to the classification information;
A central apparatus, comprising: a classification information aggregation unit that aggregates a plurality of received classification information for each identification information to generate aggregation result information. In a terminal device connected to be able to perform data communication with a central device,
Cell image display means for displaying a cell image identified by the identification information;
Classification information receiving means for receiving input of classification information of the cell image displayed by the cell image display means;
Aggregation result information receiving means for receiving aggregation result information obtained by aggregating a plurality of the classification information for each identification information in the central device;
A terminal device comprising: a totaling result information display unit capable of displaying and outputting the received totaling result information together with the classification information. The cell image display means displays identification information for identifying each cell image and cell image information associated with position information indicating the position of each cell image on the image,
Cell image selection means for accepting selection of a predetermined cell image;
Position information acquisition means for acquiring position information of the cell image that has received a selection;
Identification information specifying means for specifying identification information of the cell image based on the acquired position information,
The terminal device according to claim 5, wherein the classification information receiving unit receives the classification information of a cell image corresponding to the identified identification information.   7. The terminal device according to claim 6, wherein the cell image display means displays a specimen image including the cell image and another cell image existing within a predetermined range around the cell image.   The terminal device according to claim 6 or 7, wherein the tabulation result information display means displays and outputs tabulation result information corresponding to the selected cell image. Of the received counting result information, comprising an extracting means for extracting an item including the received classification information,
9. The terminal apparatus according to claim 8, wherein the tabulation result information display means changes a format for displaying and outputting items corresponding to the classification information extracted by the extraction means. In a computer program that can be executed by a central device connected to be capable of data communication with a plurality of terminal devices,
The central device,
Classification information receiving means for receiving the classification information of the cell image received by the terminal device and identification information for identifying the cell image corresponding to the classification information, and the received plurality of classification information for each identification information A computer program which functions as a classification information totaling means for generating totalized result information. In a computer program that can be executed by a terminal device that is connected to be capable of data communication with a central device,
The terminal device;
Cell image display means for displaying a cell image identified by the identification information;
Classification information receiving means for receiving input of classification information of the cell image displayed by the cell image display means;
Aggregation result information receiving means for receiving aggregation result information obtained by aggregating a plurality of classification information for each identification information in the central device, and the received aggregation result information can be displayed and output together with the classification information A computer program which functions as a totaling result information display means. Cell image display means for displaying a cell image identified by the identification information;
Classification information receiving means for receiving input of first classification information of the cell image displayed by the cell image display means;
Totaling result information storage means for storing totaling result information generated by totaling a plurality of second classification information for each identification information;
A terminal device comprising: total result information display means capable of displaying and outputting both the received first classification information and the stored total result information. In a computer program that can be executed by a terminal device,
The terminal device;
Cell image display means for displaying a cell image identified by the identification information;
Classification information receiving means for receiving input of first classification information of the cell image displayed by the cell image display means;
The total result information storage means for storing the total result information generated by totaling a plurality of second classification information for each identification information, and the received first classification information and the stored total result information A computer program which functions as a totaling result information display means capable of displaying and outputting.

Images