JP2009131451A - Medical administration container for maggot or egg of fly and spacer used for the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical administration container for maggots or eggs of flies maintaining the high survival rate of medical maggots even when the inside of the administration container is excessively wetted or excessively dried in addition, and expecting an excellent MDT effect, to provide a spacer used for the same, and to relatively inexpensively provide the medical administration container for maggot or eggs of flies and the spacer used for the same. <P>SOLUTION: An administration bag 1 is configured by putting the spacer 2 of a frame body and the appropriate amount of the maggots M in an activity space 3 secured inside the spacer 2 in a bag body comprising mesh cloths 10A and 10B and sealing them. The spacer 2 is constituted of a material containing sodium polyacrylate and its thickness direction height is made larger than the size of mature maggots. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a fly larvae or egg medical administration container and spacer used in MDT for treating refractory wounds and the like, and more particularly to a technique for adjusting the wet state inside the administration container.

In recent years, so-called Maggot Therapy Therapy (MDT), which treats intractable wounds, wounds and the like using medical fly larvae (Maggot), is becoming widely known.
In MDT, medical fly larvae bred without pathogenic bacteria (for example, the larvae of the fly fly Lucilia sericata; hereinafter simply referred to as “larvae”) are placed in the affected area with an appropriate number of heads. Each larva senses the necrotic tissue in the affected area, discharges a secreted fluid containing protein melting enzyme, selectively melts only the necrotic tissue on the wound surface, and absorbs and removes the melt. Larval secretions have bactericidal action against pathogenic bacteria such as drug-resistant bacteria. Thereby, for example, even if the affected part is not largely excised by surgery, the remaining healthy living tissue can be fully utilized, and a healing effect that promptly promotes granulation tissue can be expected (Non-Patent Document 1). .

Moreover, according to MDT, since the economical burden by conventional treatments such as surgery can be reduced, there is also a merit that treatment costs can be drastically reduced (Non-patent Document 2).
There are several methods for performing MDT, in addition to placing or inserting larvae directly into the affected area. Among these, there is a method of storing medical flies in the oviposition period in an administration container (administration bag) using a bag having a porous surface, and placing it in contact with the affected area (Patent Document 1).

Fig.6 (a) is a figure which shows the structure of the conventional administration bag 1x. FIG. 6B is a cross-sectional view of the administration bag 1x viewed from the direction of the arrow XX ′ in FIG.
The administration bag 1x shown in FIG. 6 (a) has mesh cloths 10A and 10B knitted with synthetic fibers (40 mm long x 60 mm wide x 200 μm thick as examples of each size) facing each other and sealed around the three sides of each other. In the bag-shaped bag body formed with the portion 11, a spacer S made of a resin material (a cube of 10 mm on a side × 10 mm in width × 5 mm in height as an example of size) and a medical fly in the oviposition period (explained in the figure) The hatched larvae M are shown in the above and are housed and sealed internally. The gap between the synthetic fibers of the mesh cloths 10A and 10B is set to an appropriate size, and when the larva M secretes the secretion into the affected area through the gap, the larva M can absorb the melt of the necrotic tissue in the affected area caused by the secretion. It is like that.

When carrying out MDT, gauze or the like is wound and fixed while bringing the administration bag 1x into contact with the affected area. According to this method, a plurality of larvae M can be easily handled by placing them in the administration bag 1x, and there is no risk that the larvae M will escape.
Japanese Patent No. 3709518 Sherman, Ronald A. et al. (2002). Wound Repair and Regeneration 10 (4), 208-214 Wayman, J.M. Walker, A .; , Sowinski, A .; & Walker, M.M. A. (2000). British Journal of Surgery 87 (4), 490-516

However, the conventional administration bag has the following problems.
In general, the wet state of the affected area varies depending on the condition of the patient, and the state of the specific affected area may vary depending on various factors. For this reason, in the administration bag, larvae that are indirectly in contact with the affected part through the porous surface are easily affected by the wet state, and may not be able to survive stably over a long period of time.

For example, if the affected area is in a dry state or if the moisture in the affected area continues to evaporate from the fiber gaps of the mesh cloth 10A, 10B due to the influence of the patient's body temperature or environmental humidity as shown in FIG. The larva M cannot acquire water necessary for survival.
Further, in such a state, the secretion of the larva M is absorbed by the fibers of the mesh cloth 10B and does not reach the affected area, and conversely, the melted necrotic tissue of the affected area is absorbed by the fibers of the mesh cloth 10B and dissipated. There is also a possibility that the larva M will die due to lack of nutrition. In order to prevent this problem, it may be possible to hydrate the administration bag 1x with physiological saline or the like in advance. However, it is necessary to repeat the operation over the administration period of the administration bag 1x, and it is necessary for doctors and nurses. Work burden increases.

  On the other hand, when the affected area is excessively wet, as shown in FIG. 6 (b), the administration bag 1x is filled with water through the fibers of the mesh cloth 10B. For this reason, there is no activity space in which the larvae M can move around in the administration bag 1x, and the larvae M may be drowned. In addition, if the affected area is excessively wet, the melt produced by the secretion of the larvae M may be dissipated in the infiltrated water, and the larvae M may not be absorbed well and may be debilitated.

In addition, when the affected part is excessively wet, the moisture of the affected part spreads around the administration bag 1x, and there is a problem of hygiene such as adhering to gauze, clothing, and bedding.
Regarding each of the above problems, there is another problem that makes it difficult to predict a change in the wet state of the affected area. Therefore, even if the wet state of the affected area changes between management by a doctor or nurse, it is necessary to maintain the sufficient effect of MDT while properly allowing the larva M to survive in the administration bag.

Although the administration bag 1x in FIG. 6 contains a spacer S having a predetermined size and shape, it is still insufficient as a function for properly protecting the larva M when an external pressure is applied to the administration bag 1x. It is. Therefore, there is also a need to more reliably increase the survival rate of larvae in the administration bag over the period of MDT.
When performing MDT in this way, there are still some problems to be solved regarding the medical administration container for fly larvae or eggs and the spacer used therefor.

The present invention has been made in view of the above problems. As a first object, even when the inside of the administration container can be excessively wetted, the inside of the administration container is maintained in an appropriate wet state. Provided are a medical administration container for fly larvae or eggs, which can maintain a high survival rate of medical fly larvae and can be expected to have a good MDT effect, and a spacer used therefor.
As a second purpose, in addition to the above purpose, even if the inside of the administration container can be excessively dried, the high survival rate of medical fly larvae can be maintained by keeping the inside of the administration container in an appropriate moist state. Provided are a medical administration container for fly larvae or eggs, which can be expected to have a good MDT effect, and a spacer used therefor.

  As a third object, in addition to the above-mentioned objects, a medical administration container for fly larvae or eggs and a spacer used therefor are provided at a relatively low cost.

  In order to solve the above-described problems, the present invention provides a medical administration container for fly larvae or eggs in which a spacer is housed in a bag-shaped bag body, and the surface of the bag body in contact with the affected area is porous. The spacer is configured to include a frame body or a plate body having a corrugated cross-sectional shape, or a plurality of pieces arranged apart from each other, and at least a part of the spacer exhibits water absorption or additionally drainage. It is assumed that a fly larva activity space exists on the inside of the frame body or the surface of the plate body having a corrugated cross-sectional shape, or at least the space surrounded by the plurality of pieces.

Here, the frame may have a flat outer shape.
Further, the spacer may be made of a material containing at least one of sodium acrylate, vinyl alcohol, and isopropyl acrylamide with respect to the base.
Each of the plurality of pieces may be fixed to the bag body.

  Furthermore, the bag body can be configured by mesh cloth on both the one surface that contacts the affected part and the other surface. Alternatively, the bag body may be configured such that one surface in contact with the affected part is configured with a mesh cloth and the other surface is configured with a nonwoven fabric. When adopting any one of these configurations, in the internal space of the bag-shaped bag body, contact between one surface of the bag body and the other surface is avoided by the intervention of a spacer housed in the bag body. It can also be configured.

Further, the present invention is a medical administration container spacer for fly larvae or eggs, comprising a frame or a plate having a corrugated cross-sectional shape, or a plurality of pieces arranged apart from each other, and In addition, at least a part of the material is formed of a material that absorbs water or has drainage in addition to this.
Here, the frame may have a flat outer shape.

Moreover, it can also be set as the structure where the active space of the larva of a medical fly exists in the surface of the internal space of the said frame or the plate body which has a waveform cross-sectional shape.
The spacer can be made of a material containing at least one of sodium acrylate, vinyl alcohol, and isopropylacrylamide with respect to the substrate.

According to the fly larvae or egg medical administration container of the present invention having the above-described configuration and the spacer used therefor, since the spacer is made of a material that absorbs water, the wet state inside the administration container can be reduced. It can be maintained moderately, and the effect of improving the survival rate of larvae is exhibited.
That is, when the affected area is excessively wet or the environmental humidity is high, the spacer absorbs excessive moisture even if excessive moisture enters the administration container. Thereby, it can be avoided that the activity space of the larvae in the administration container is filled with water, and the death of the larvae can be prevented. Furthermore, since the water absorption of the spacer can reduce excessive wetting in the affected area, the healing effect is promoted, and a hygiene effect that prevents contamination of the environment such as gauze, clothing, and bedding around the administration container can be expected. Is.

  Furthermore, when the affected area is excessively dry or the environmental humidity is low, the material of the spacer exhibits water absorption and drainage (a material that absorbs water when there is a lot of water and drains when there is little water) ), The moisture once absorbed by the spacer is diffused to the surroundings, and the humidity in the administration container is kept moderate. Thereby, in addition to replenishing the larvae with water necessary for survival, the administration container itself is also maintained at an appropriate humidity. Therefore, when the larva secretes the secretion in MDT, the secretion is suppressed from being absorbed into the bag body on the porous surface, and the necrotic tissue melt of the affected area also reaches the larva appropriately. As a result, an appropriate effect of MDT can be obtained, and larvae can be prevented from debilitating due to lack of nutrition.

In the present invention, it is also possible to include a base material in the spacer. In this case, a spacer having a certain mechanical strength can be realized. For this reason, even when an external pressure is applied along the height direction of the spacer, the larvae's active space is well maintained by the spacer, so that the larvae can be effectively prevented from being killed by the external pressure.
In addition, if the spacer in the present invention is made of a material containing at least one of sodium acrylate, vinyl alcohol, and isopropyl acrylamide, which is a known material as a material that exhibits water absorption and drainage, the present invention can be realized at a relatively low cost. This is a very significant advantage in implementing MDT.

  As described above, since the present invention synergistically exhibits the effect of appropriately controlling the humidity inside the administration container and also prevents the larvae from being killed, it is extremely excellent in increasing the survival rate of the larvae in MDT. Usefulness can be expected.

Each embodiment and each modification of the present invention will be described below, but the present invention is naturally not limited to these embodiments, and can be modified as appropriate without departing from the technical scope of the present invention. Can be implemented.
In FIGS. 1, 2 and 4, the fiber gaps are roughly shown for clarity of illustration of the internal structure of the administration bag 1, but in reality, the eyes are fine on the order of several hundred μm.

<Embodiment 1>
FIG. 1 (a) is a diagram showing a configuration of a medical fly larva administration bag 1 (hereinafter simply referred to as "administration bag 1") in Embodiment 1 of the present invention. FIG.1 (b) is sectional drawing seen from the XX 'arrow direction of the administration bag 1 in Fig.1 (a).
The administration bag 1 shown in FIG. 1 (a) has a frame-like spacer 2 on a bag-shaped bag body in which mesh cloths 10A and 10B are opposed to each other and three sides of each other are sealed with a sealing portion 11. The bag body is internally sealed after an appropriate amount of larvae M is placed in the activity space 3 secured inside the spacer 2.

  The mesh cloths 10A and 10B are woven mesh-structured porous sheets in which synthetic fibers such as nylon and polyester having an average fiber diameter of several tens of μm are knitted so that the fiber gap is about 114 μm. As an example of the outer dimensions of the mesh cloths 10A and 10B, the size can be 40 mm in length, 60 mm in width, and 200 μm in thickness. In addition, as an example of the vertical and horizontal sizes, any of 25 mm long × 50 mm wide, 50 mm long × 70 mm wide, and 60 mm long × 130 mm wide can be exemplified. The mesh cloths 10A and 10B exhibit porosity on the surfaces due to the fiber gaps. As a result, the moisture in the affected area is conducted to the larva M side in the bag 1, and the melt generated by the secretion fluid released from the larva M melts the affected tissue again to form the larva M in the administration bag 1. It has come to reach.

In addition, although each material of mesh cloth 10A, 10B is not limited to the above, when implementing MDT, it is necessary to satisfy the following requirements.
a. Less skin irritation.
b. The larvae M having a body length of 1 mm cannot pass through and have excellent liquid permeability.
c. It has a strength that is not broken by larvae M matured to 1 cm in length.

d. It has the flexibility to adhere to uneven affected areas.
e. Can be sterilized in an autoclave.
f. It can be sealed by thermocompression bonding.
It is preferable that the mesh cloths 10A and 10B are made of nylon or polyester because both the requirements a and cf are satisfied. The requirement b is adjusted according to the roughness of the fiber gap (mesh). According to experiments, when the larvae M are about 1 mm in size, it is confirmed that the fibers escape to the outside when the fiber gap is about 211 μm. On the other hand, it has also been confirmed that this problem does not occur when the fiber gap is 114 μm. Therefore, an appropriate fiber gap can be exemplified by around 114 μm. In addition, the fiber gap can be freely adjusted according to the size of the larvae M to be used. However, when the range is approximately 90 μm or more and 114 μm or less, the larvae M in any growth state are less likely to escape to the outside, and It is considered preferable because the larva M can absorb the lysate of the necrotic tissue in the affected area through the fiber gap.

  The spacer 2 is a frame having a rectangular flat plate-like outer shape, and an example of the size in the outer shape is 35 mm long × 45 mm wide × 5 mm high. Moreover, the size example of the activity space 3 ensured inside the spacer 2 is 25 mm long × 35 mm wide × 5 mm high. The size of the active space 3 can be secured widely, for example, by increasing the outer shape while maintaining the width of the frame of the spacer 2. The activity space 3 is a main living space for the larvae M in the administration bag 1. In consideration of the fact that the larvae M can act well, it is desirable to devise measures such as making the height h (see FIG. 4) of the activity space 3 higher than its maximum growth size (maximum thickness).

As a reference, the final body length of the larvae M of the flyfly is generally 11 to 12 mm and the maximum thickness (diameter) is about 3 mm, but there are also larvae that have a maximum body length of 13 mm and a maximum thickness (diameter) of about 4 mm.
In addition, the spacer 2 can be made thin, but in this case, protrusions (not shown) protruding in the direction of height h are separately provided at the four corners of the top surface 20 and the like, whereby the thickness of the administration bag 1 itself. It is preferable to devise measures to increase the survival rate of the larvae M by ensuring the above. It is also desirable that a part of the top surface 20 is thermocompression bonded to the mesh cloth 10A so that the spacer 2 is not displaced in the administration bag 1 due to vibration or the like.

The main feature of the spacer 2 here is a material in which a polymer having moisture conditioning properties (both water absorption and drainage properties) is dispersed in a polymer substrate.
Examples of the polymer substrate include polyester polyol, but the present invention is not limited thereto. In addition, specifically, polyether polyol, polyether ester polyol, polyester amide polyol, acrylic polyol, polyurethane polyol, epoxy polyol, epoxy-modified polyol, polyhydroxyalkane, oil-modified polyol, castor oil, or main chain is C One or more of a polyol comprising a -C bond, an etherified product obtained by partially blocking the hydroxyl group of the polyol with an alcohol or a carboxylic acid, and an esterified product can be used.

The polymer substrate is used for imparting appropriate mechanical strength to the spacer 2 and preventing excessive expansion of the humidity-adjusting polymer during water absorption.
On the other hand, sodium polyacrylate (PA) can be used as the humidity control polymer. In addition, a water-soluble vinyl monomer or a polymer obtained by crosslinking a water-soluble vinyl monomer polymer with a crosslinking agent can be exemplified. Examples of the water-soluble vinyl monomer include hydrophilic properties such as at least one carboxylic acid (salt) group, sulfonic acid (salt) group, phosphoric acid (salt) group, hydroxyl group, amide group, amino group, and quaternary ammonium base. And a polymerizable monomer having a group.

Here, examples of the vinyl monomer that becomes water-soluble by hydrolysis include monomers having at least one hydrolyzable group (such as an ester group, a nitrile group, and an amide group).
Examples of the monomer having an ester group include lower alkyl (C1-C3) esters of monoethylenically unsaturated carboxylic acid [for example, methyl (meth) acrylate, ethyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, etc.] And esters of monoethylenically unsaturated alcohols [for example, vinyl acetate, (meth) allyl acetate, etc.]. Examples of the monomer having a nitrile group include (meth) acrylonitrile.

Of these, water-soluble vinyl monomers are preferred. More preferred are monomers having a carboxylic acid (salt) group and a sulfonic acid (salt) group, and particularly preferred are acrylic acid and / or acrylate as in the case of PA. These polymerizable monomers may be used alone or in combination of two or more if necessary.
The spacer 2 is not limited to a method obtained by injection molding the organic material into a mold. For example, a knitted fabric or a nonwoven fabric (felt structure) can be produced by spinning with the organic material, and the resultant synthetic fiber can be laminated with a predetermined thickness. Use of the synthetic fiber is preferable because the surface area of the humidity-adjusting polymer that is in contact with the outside air is remarkably increased, and good air circulation is ensured in the gap between the fibers. As a result, the spacer 2 can be expected to have both good water absorption and drainage effects and high immediate effect.

The implementation steps of MDT using the administration bag 1 having the above configuration can be exemplified as follows.
1. Mesh cloths 10A and 10B that have been autoclaved at an appropriate temperature and pressure in advance are prepared, and the bag body is prepared by sealing the periphery of each other.
2. A sterilized spacer 2 and a suitable number of larvae M are placed in the bag body. The larva M is a medical product that has been hatched and grown in a predetermined biotope that is consistently managed. The number of larvae M is a standard of 5 to 10 per 1 cm ² of the affected area.

3. Thereafter, the administration bag 1 is obtained by internally sealing the bag body.
4). When the affected part is in a dry state, the mesh cloths 10A and 10B of the administration bag 1 are previously moistened with physiological saline or the like. Then, in order to arrange the administration bag 1 so that the protein-containing material (the patient's necrotic tissue) is in contact with the surface of the mesh cloth 10B, the mesh cloth 10B is brought into contact with the affected area, and gauze or the like is wound around the affected area to administer the administration bag 1. To fix. At this time, the number of turns of the gauze, the winding strength, etc. are adjusted so that the larva M can breathe in the open air.

In the administration bag 1 arranged in this way, each larva M in the activity space 3 secretes a secretion solution containing a protein melting enzyme to the necrotic tissue in the affected area via the surface of the mesh cloth 10B. The resulting melt of necrotic tissue is again absorbed through the mesh cloth 10B. By this cycle, the larva M survives in the administration bag 1 for a certain period.
The administration bag 1 is normally replaced every 48 to 72 hours. The old administration bag 1 after replacement is properly disposed as medical waste. When this administration cycle is repeated 2 to 6 times, normally, the necrotic tissue in the affected area is almost removed, and the secretory fluid produced by the larva M promotes the healing of the affected area.

Applicable diseases for MDT include diabetic ulcers and gangrene, leg ulcers (ischemic diseases, congestive diseases, neurological diseases, etc.), wounds (bed sores), refractory infection wounds (MRSA, MDRP infection, etc.), etc. Intractable wounds (postoperative wounds, trauma, burns, etc.) can be mentioned.
According to the administration bag 1 of the first embodiment based on the above configuration and method of use, the spacer 2 appropriately maintains the wet state in the administration bag 1, so that the effect of increasing the survival rate of the larvae M is exhibited.

  That is, since the spacer 2 contains sodium polyacrylate (PA) exhibiting water absorption and water release characteristics, even if the affected area is in an excessively wet state or is affected by the environmental humidity, Even when excessive moisture permeates into the spacer 2, the spacer 2 appropriately absorbs the excessive moisture (FIG. 4). As a result, the activity space 3 in the administration bag 1 is not filled with water, and the risk of the larva M dying is drastically reduced. In addition, the activity space 3 for the larva M to move around and grow is secured well. The In addition, since the spacer 2 has an action of eliminating excessive wetting in the affected area, it promotes a healing effect and can prevent contamination of the gauze, clothing, bedding, etc. around the administration bag 1 and is high in terms of hygiene. The effect is demonstrated.

  On the other hand, when the wet state of the affected part dries, the moisture contained in the sodium polyacrylate is released to the surroundings, and the humidity in the bag 1 is kept moderate (FIG. 4). Due to this effect, moisture necessary for survival is supplied to the larvae M, and the mesh cloths 10A and 10B are also kept at an appropriate humidity. Therefore, even if the larva M secretes the secretion, it is suppressed from being absorbed by the fibers of the mesh cloths 10A and 10B, and the melt of the necrotic tissue in the affected area also reaches the larva M appropriately with the same effect. Therefore, there is no shortage of nutrients for the larvae M. In addition, since the secretion of the larva M sufficiently reaches the affected area immediately below the spacer 2 and the melt of the necrotic tissue of the affected area also reaches the larva M, the effect of MDT can be achieved by using the spacer 2. There are very few problems that cause variations.

  Further, as shown in FIG. 1B, the spacer 2 has a sufficient height h, and a polymer substrate is included as a material, so that it has an appropriate strength. For this reason, even if pressure is applied to the spacer 2 from the height direction from the outside, the spacer 2 is not crushed and the shape is appropriately maintained. Therefore, since the active space 3 surrounded by the spacer 2 is also well maintained, the problem that the larva M is killed by pressure from the outside can be avoided.

In the present invention, since each of the above effects is exhibited synergistically, the wet state in the administration bag 1 is kept stable, and the survival rate of the larvae M is increased over a long period of time. Furthermore, since any of the administration bags 1 described above can be made of a known material, it has an advantage that it can be realized at a relatively low cost.
In addition, although the administration bag 1 exhibits moderate sustained release regarding water | moisture content, a water | moisture content can also be included in the spacer 4 before or during implementation of MDT. In this way, since the water in the spacer 4 is effectively released into the administration bag 1 and the affected part, when the affected part is excessively dried and the state can be continued, A good effect of MDT can be expected. In addition, since sodium polyacrylate releases the moisture once sucked in (usually has the property of releasing moisture for about a month at room temperature), it is not necessary to replenish the spacer 4 frequently. Handling is also very easy.

Further, as the material of the spacer 2, it is possible to use a material that exhibits only water absorption (silica gel or the like) in addition to the above-described humidity-controlling polymer. However, when a hydrate is formed by water absorption, it may be accompanied by fever, but care must be taken so that the larvae M are not adversely affected by this.
Hereinafter, other embodiments will be described focusing on differences from the embodiments.

<Embodiment 2>
FIG. 2A is a diagram showing a configuration of the administration bag 1a of the second embodiment. FIG. 2B is a cross-sectional view seen from the direction of arrows XX ′ in FIG.
The administration bag 1a differs from the administration bag 1 in that a large-sized spacer 2a that covers almost the entire internal volume of the bag body is accommodated in the bag body, whereby an annular peripheral space 3A is formed along the outer edge of the spacer 2a in the bag body. Is formed, and the close contact between the mesh cloths 10A and 10B in the internal space of the bag body is avoided.

  That is, according to the administration bag 1a, the same effects as those of the first embodiment are obtained at the time of use. Further, by adopting the large spacer 2a, as shown in FIG. 2 (b), the mesh cloths 10A and 10B are stretched from the outer edge of the spacer 2a to the sealing portion 11 and are substantially inside the bag body. A peripheral space 3A having a triangular cross-sectional shape is formed, and adhesion between the mesh cloths 10A and 10B is prevented. With this device, even when the affected part is in an excessively wet state, the mesh bag 10A, 10B around the spacer 2a sticks to each other and the internal space of the bag main body is lost in the administration bag 1a due to the intervention of the spacer 2a. Therefore, as shown in FIG. 7A, the larva M enters the internal space and is prevented from suffocating between the mesh cloths 10A and 10B. Therefore, according to the second embodiment, the survival rate of the larvae M can be further increased, and an excellent MDT effect can be expected.

<Embodiments 3 and 4>
FIG. 3A is a cross-sectional view showing a configuration of the administration bag 1b of the third embodiment. The administration bag 1b is characterized in that a spacer 2b made of a plate having a zigzag corrugated cross-sectional shape is used in place of the spacer 20.
FIG. 3B is a cross-sectional view showing the configuration of the administration bag 1c of the fourth embodiment. The administration bag 1c is characterized in that it uses a spacer 2c made of a plate having a wavy cross-sectional shape meandering in a rectangular shape.

  In any of the administration bags 1c and 1d having the above-described configuration, the same effects as those of the first embodiment are exhibited when the MDT is performed. In addition to this, by adopting the spacers 2b and 2c, a plurality of groove-like activity spaces 3 are abundantly secured on the respective main surfaces. The larva M works well in the administration bags 1b and 1c while moving along the longitudinal direction of the groove in the active space 3 existing on both sides of the spacers 2b and 2c and moving to the adjacent groove. can do.

In addition, in the administration bags 1b and 1c, like 1a, the size of the spacers 2b and 2c may be set larger than the internal space of the bag body, and a device may be devised to secure the peripheral space 3A.
<Embodiment 5>
The fifth embodiment of the present invention will be described focusing on differences from the first embodiment.

FIG. 4A is a diagram showing a configuration of the administration bag 1d of the fifth embodiment. FIG. 4B is a cross-sectional view seen from the direction of arrows XX ′ in FIG.
A feature of the administration bag 1d is that a spherical spacer 2d with a total of eight spacers is put into a bag body made of mesh cloths 10A and 10B, and a plurality (in this case, a total of eight) are provided along the periphery of the sealing portion 11 and predetermined. The point is that they are spaced apart from each other. Each spherical spacer 2d is in the form of a bead having a diameter of 5 mm, and each is made of the same material as that of the spacer 2, and a part of each outer surface is fixed at the thermocompression bonding portion 32 of the mesh cloth 10A, 10B. The fixing using the thermocompression bonding prevents the larvae M from being pinched between the spherical spacers 2d and killed by pressure. The spacer of the present invention is not limited to one member, and may be constituted by a combination of such a plurality of pieces (here, the spherical spacer 2d).

In the administration bag 1d, the inner space 3 surrounded by the spherical spacers 2d and the periphery 21 of the spherical spacer 2d are active spaces for the larvae M.
Even in the administration bag 2a having such a configuration, since the spherical spacer 2d exhibits water absorption and sustained release of moisture, the affected area is excessively wet or dry, or the environmental humidity varies. Even if it exists, the inside of a bag is adjusted appropriately like Embodiment 1, and the effect of a favorable MDT is show | played.

In addition, when pressure is applied from the outside along the thickness direction of the administration bag 1d, a total of eight spherical spacers 2d are subjected to stress in the diameter direction and slightly bent as shown in FIG. 4 (b). As a result, the pressure is alleviated to reach the entire administration bag 1d. Thereby, the larva M in the activity spaces 3 and 21 can survive well without crushing.
Furthermore, if the spherical spacer 2d is used, it is not necessary to set the spacer size finely according to the size of the administration bag. That is, if the size of the administration bag is large, a relatively large number of sphere spacers are used. If the size is small, the number of the sphere spacers is reduced, and the living space 3, 21 can be appropriately secured inside the bag body. is there.

<About variations of spacers>
FIGS. 5A to 5E are diagrams showing various modifications of the spacer in the present invention.
A feature of the spacer 2e shown in FIG. 5 (a) is that ribs 23 and 24 are arranged in a lattice shape inside a rectangular frame 22 similar to the spacer 2 described above. Thereby, in the spacer 2e, the activity space 3a-3d divided into four is ensured. The spacer 2e is used in place of the spacer 2 and is housed in the administration bag 1 having the same configuration as in the first embodiment.

If the spacer 2e having the above configuration is used in the administration bag of the present invention, the same effects as those of the first embodiment can be obtained, and the presence of the ribs 23 and 24 can be used to twist the main surface of the spacer 2e. The strength can be further increased. For this reason, the survival rate of the larva M introduced into each of the activity spaces 3a to 3d is further increased.
Furthermore, in the spacer 2e, the larvae M can be dispersed and arranged in each of the activity spaces 3a to 3d, so that the larvae M are prevented from being unevenly distributed to the affected area, and appropriate MDT can be performed.

In addition, since the mass of the spacer is increased as compared with the spacer 2, it is possible to make the water-absorbing polymer abundantly contained in that amount, and a higher-capacity humidity adjustment effect can be expected in the administration bag 1. ing.
In FIG. 5A, the two ribs 23 and 24 are provided. However, the number of ribs provided on the spacer is not limited to this and may be two or more.

The outer shape of the spacer is not limited to a rectangular shape, and may be a spacer 2f in which ribs 26 and 27 are arranged on an elliptical or circular frame 25 as shown in FIG. In this case, the same effect as the spacer 2e is obtained.
The outer shape of the spacer is not limited to 2e or 2f, but may be a polygonal shape. Furthermore, the number of spacers is not limited to one, and two or more spacers may be arranged in the administration bag. However, it should be noted that in any case, an activity space necessary for the survival of the larvae M should be secured.

  Furthermore, as shown in FIG. 5C, a spacer 2g in which triangular reinforcing portions 28 are disposed at the four corners of a rectangular frame can be used. According to this configuration, in addition to the effects of the first embodiment, the active activity of the larvae M is secured in the relatively wide activity space 3i, and the deformation of the spacer 2g is more reliably prevented by the reinforcing portion 28. The larva M can be reliably protected. In addition, the shape of the reinforcement part 28 is not limited to a triangular shape, For example, another polygonal shape may be sufficient.

  Here, the spacer structure does not need to be formed as an integral member. As shown in FIG. 5D, for example, four-piece spacer members 29A to 29D made of a plate-like body having a ginkgo-shaped main surface are symmetrical to each other. The spacer 2h may be configured. The spacer members 29A to 29D are fixed to the mesh cloths 10A and 10B by thermocompression bonding so as not to be displaced. Also in the spacer 2h having this configuration, the active space 3j is secured by being surrounded by the four pieces of spacer members 29A to 29D, and the same effect as in the first or second embodiment is exhibited.

In addition, the number of pieces of a spacer member should just be two or more. In the case of two, the structure which arrange | positioned the spacer member of the plate-shaped body which has a U-shaped main surface mutually opposed can be illustrated.
A spacer 2 i shown in FIG. 5E is a rectangular plate-shaped body 30 having a columnar support 31 disposed at the center of the lower main surface thereof. As a result, the periphery of the support 31 in the vicinity immediately below the plate-like body 30 becomes the active space 3k of the larva M. The other main surface of the support 31 is disposed so as to contact the surface of the mesh cloth 10B of the administration bag 1.

  According to the spacer 2i having such a configuration, the same effects as those of the first or second embodiment can be obtained, and the plate-like body 30 is widely arranged along the surface of the mesh cloth 10A. The active space 3k is effectively protected from the outside by the plate 30. In addition, the presence of the plate-like body 30 also has an effect of making the larvae M not easily visible from the mesh cloth 10A side, so that it can be said that there is an advantage in application to patients who have mental resistance to the implementation of MDT. This visual effect can be further enhanced by combining with a coloring treatment of a porous sheet or mesh cloth described later.

In addition, the support body 31 is not limited to one, and for example, a total of four support bodies 31 may be provided at four corners of the plate-like body 30. In this case, each column may be a prism as well as a cylinder, and the spherical spacer 2d of the fifth embodiment can be used.
<Performance confirmation experiment>
(Examination of water absorption capacity of spacer material)
Various materials were compared for the performance of the spacer material used in the administration bag of the present invention.

As an experimental method, first, spacers made of materials having the following configurations were prepared as Comparative Examples 1 and 2 and Example 1. The spacers have a rectangular surface for the purpose of facilitating comparison.
Comparative Example 1: Spacer made of a sponge-like PVA material. The size was 10 mm long × 10 mm wide × 10 mm high, and the same configuration as the spacer S was adopted.

Comparative Example 2: A spacer formed by wrapping PA in a cotton pulp outer package. The size was 10 mm long × 10 mm wide × 3 mm thick.
Example 1 A spacer composed of a non-woven fabric of fibers obtained by mixing a polymer material with a base material and PA. The size was 10 mm long × 10 mm wide × 1 mm thick.
About each said spacer, the weight before and behind water absorption at the time of being immersed in water each separately, and the shape change visually were confirmed.

  The experimental results obtained at this time are shown in Table 1 below.

当該実験結果では、比較例２で吸水量が最も高いことが分かったが、吸水後にスペーサーの周囲からＰＡの水和物である含水ゲルが大量に漏出するのが確認された。これは、吸水したＰＡが急激に体積膨張し、綿状パルプの外装体を押しのけて外部に漏れ出た結果であると考えられる。従って、このような比較例２のスペーサーをそのまま用いれば、投与バッグ内で発生した含水ゲルが幼虫Ｍを圧死又は窒息死させるおそれが高いため、実用的ではないと思われる。

In the experimental results, it was found that the amount of water absorption was the highest in Comparative Example 2, but it was confirmed that a large amount of water-containing gel, which is a hydrate of PA, leaked from the periphery of the spacer after water absorption. This is considered to be a result of the sudden volume expansion of the absorbed PA, and the leakage of the cotton-like pulp exterior to the outside. Therefore, if such a spacer of Comparative Example 2 is used as it is, there is a high possibility that the hydrated gel generated in the administration bag will cause the larvae M to be crushed or suffocated to death, which is not practical.

  On the other hand, it was confirmed that Comparative Example 1 composed of sponge-like PVA had substantially the same water absorption as Example 1. Moreover, in Example 1, PA which is a component which exhibits the same water absorbency as Comparative Example 2 is included, and this demonstrates water absorption comparable to that of Comparative Example 1, but it is excessive as in Comparative Example 2. It was confirmed that there was no water absorption and no leakage of the hydrogel occurred. This is because the non-woven fiber constituting the spacer of Example 1 is not PA itself, but PA is dispersed in the base polymer material, and the amount of PA used per unit volume is small and water is absorbed. This is probably because the volume expansion of PA was physically suppressed by the polymer structure of the substrate, and a water-containing action exceeding a certain level was avoided. In addition, although not confirmed in this experiment, the spacer of Example 1 has a sufficient effect of gradually releasing moisture from PA once absorbed due to the suppression effect by the polymer of the substrate. It is thought that there is.

  From the above results, it was confirmed that the spacer of Example 1 using a mixed material of PA and substrate had the highest utility. Further, from the results of Comparative Example 1, it was found that a certain practical water absorption effect can be expected even with a spacer using a sponge-like PVA material. Therefore, it is considered that good effects can be expected even when PVA is used instead of PA in the configuration of Example 1.

(Examination of effectiveness of spacer of the present invention)
Next, the various spacers used in the administration bag were actually used, and their effectiveness was examined.
The specific examination method was as follows.
a. In order to prepare the larva M, the hatched larva M was grown on a pork liver for 2 days until the body length became 3 to 4 mm.

b. Two nylon mesh cloths (fiber gap; length 189 μm × width 175 μm) were overlapped, and the periphery of each side was welded with a heat sealer to prepare four envelope-type bag bodies 30 mm long × 40 mm wide. Using these, two bag bodies were prepared for each of the following four types of bags.
Bag A; Spacer not used Bag B; Use a spacer consisting of one sheet of Comparative Example 1 Bag C; Use a spacer formed by laminating 10 sheets of Example 1 Bag D; From one sheet of Comparative Example 2 C. Next, assuming the normal affected area in a relatively dry state and the affected area in a wet state with a large amount of exudate, the following two types of experimental beds (N bed and W bed) were prepared.

N (Normal) floor; assuming a normal affected area, 10 g of a thawed fresh pig liver was placed in an aluminum foil case.
W (Wet) floor: Assuming a wet affected area, 10 g of a thawed fresh pig liver was placed in an aluminum foil case, and 2.5 ml of physiological saline was further poured.
d. Thirty larvae M were put into each bag body prepared in b and sealed with a heat sealer to obtain two bags A to D, respectively. Bags A to D were respectively placed on the N-bed and W-bed levers prepared in c and grown for 3 days under conditions of 26 ± 1 ° C. The effect of the spacer was confirmed by the number of surviving larvae M and the length.

  The experimental results at this time are shown in Table 2 below. In Table 2, A to D indicate the type of each bag, and the following N or W indicates that they are arranged on the N floor and the W floor, respectively.

まず、スペーサーを用いない投与バッグでは、Ａ-Ｎ、Ａ-Ｗの結果が示すように、いずれも幼虫Ｍが全て死滅した。投与バッグを目視で確認したところ、バッグ本体の上下のメッシュクロスが浸出液で密着し、その間に幼虫Ｍが挟まれて溺死していた。

First, as shown by the results of A-N and A-W, all of the larvae M were killed in the administration bag without using a spacer. When the administration bag was visually confirmed, the upper and lower mesh cloths of the bag body were in close contact with the leachate, and the larvae M were sandwiched between them and were drowned.

  In B-N and B-W, the survival rate of the larvae M was not high, and in B-W, all the larvae M were killed. Moreover, only 10 animals survived in BN. In the BN administration bag, the upper and lower mesh cloths are not attached in the vicinity of the spacer, and the larvae M in the vicinity are alive, but as shown in FIG. At the periphery of the distant mesh cloth, the exudate was filled, and the larvae M were drowned in the area. Such moribund death of the larvae M is expected to become prominent when, for example, the size of the spacer is smaller than that of the bag body.

  According to another experiment of the present inventor, even in the configuration like the bag B, as shown in FIG. 7 (b), the spacer to be inserted into the bag body is a cube, and the size is the inside of the bag body. By making it large relative to the space (for example, large enough to reach more than half of the internal space of the bag body), it is possible to prevent the upper and lower mesh cloths from sticking to each other with the leachate, and to ensure a good living space for the larva M Has been confirmed.

  In the experimental results of DN and D-W, the water absorption was the highest, but the spacer rapidly expanded in volume with the water absorption, and the PA gel-like hydrate diffused and filled inside the bag. For this reason, there was no active space inside the bag, and the larvae M were killed in any bag. The spacer used for the bag D was the thinnest among the spacers used in the experiment, but the volume expanded most rapidly among them. From this result, it was found that the spacer in the bag D is not suitable for practical use.

On the other hand, in the administration bag C using the spacer of Example 1, the larvae M were all killed in C-W, but the survival of 28 larvae M was confirmed in CN. In this experiment, it is considered that the formation of a space around the spacer was effective.
In this case, in order to make a comparison based on the material of the spacer, cubic spacers were used in C-N and C-W. Here, since the good survival of the larvae M was confirmed in CN as described above, if the spacer having the shape shown in Embodiments 1 to 5 is produced using the material of the spacer, the affected area becomes wet. Even if it exists, it is thought that the larva M can be made to survive well in the activity space.

From the above experimental results, the superiority of the present invention could be confirmed.
<Variation of water-absorbing polymer>
In each of the above-described embodiments and modifications, the configuration using sodium polyacrylate (PA) or the like as the moisture-adjusting polymer is shown, but the present invention is not limited to this, and various water-absorbing polymers are structured. Can be used in combination. For example, it is also possible to use a configuration in which a water-soluble polymer is separately introduced into a three-dimensional structure skeleton made of sodium polyacrylate. As the water-soluble polymer, polyisopropylacrylamide (PNIPAM) can be used in addition to polyvinyl alcohol (PVA).

  According to such a structure using a water-absorbing polymer, compared to the case of using sodium polyacrylate alone, the effect as a humidity control material in which absorbed moisture is diffused to the surroundings relatively early is improved. Can do. That is, when water is taken into the sodium polyacrylate skeleton, the water-soluble polymer swells and a small water mass is generated in the skeleton. Since this water mass is sufficiently smaller than each side of the skeleton, it easily evaporates thereafter.

  Therefore, an administration bag having a spacer using this humidity control material can positively absorb excess water quickly, while also having an effect of quickly diffusing absorbed and removed water to the surroundings as water vapor. Accordingly, there is an advantage that an environment suitable for long-term survival of the larvae M is easily formed without excessively absorbing the moisture in the administration bag and causing the wet state to be dry at once.

<Other matters>
The larvae M in the present invention are not limited to the white fly, but a wide variety of fly larvae such as the family Diptera, Muscidae, Muscidae, and Drosophila can be used.
In each embodiment and each modified example, a spacer containing a humidity-controlling polymer is shown. However, when the administration bag is used for a long time in a dry environment, sufficient release of moisture can be achieved with only the spacer. May be difficult. In this case, a known moisturizing agent having hydrophilicity and cold keeping properties such as polyethylene glycol (PEG) may be provided inside the administration bag together with a spacer.

  In addition, the bag body in the present invention is not limited to the configuration using the mesh cloths 10A and 10B, and at least the surface that contacts the affected part may be the mesh cloth 10A and the other surface may be the nonwoven fabric. Furthermore, you may use porous sheets other than a mesh cloth for the structure of the bag main body with a porous surface. For example, a sheet made of a film made of nylon, polypropylene or the like and having a large number of holes in the film can be exemplified.

Here, by using the above-mentioned non-woven fabric or coloring a part or more of the porous sheet or mesh cloth with a dark color, the larvae M inside the administration bag 1 can be made invisible easily from the outside, and the visual Can be expected to be effective. Such a device is effective for patients who have a mental resistance to MDT.
Furthermore, the administration container of the present invention is not limited to an administration bag formed by laminating a porous sheet or mesh cloth. For example, a resin plate having a porous surface may be laminated with a frame interposed therebetween. Good.

  In the above-described embodiment, the configuration in which the larva M is put in the administration bag is illustrated, but the present invention is not limited to this, and the flies in the oviposition period (fly eggs) can also be put in the administration bag. In this case, eggs are hatched in advance before use, and after the larvae M are grown to an appropriate growth period, the administration bag is used.

  INDUSTRIAL APPLICABILITY The present invention can be used as a means for appropriately administering medical fly larvae to affected areas in MDT, which is part of intractable wound treatment.

3 is a diagram showing a configuration of an administration bag in the first embodiment. FIG. 6 is a diagram showing a configuration of an administration bag according to Embodiment 2. FIG. It is a figure which shows the structure of each administration bag in Embodiment 3 and 4. FIG. It is a figure which shows the structure of the administration bag in Embodiment 5. FIG. It is a figure which shows the various modifications of a spacer. It is a figure which shows the structure of the conventional administration bag. It is a figure for demonstrating the effect of the spacer in an administration bag.

Explanation of symbols

M Larva 1, 1a-1d, 1x Medical fly larvae administration bag 2, 2a-2i Spacer 3, 3a-3k, 21 Activity space 3A Peripheral space 10A, 10B Mesh cloth 11 Sealing portion 20 Top surface 22, 25 Frame body 23, 24, 26, 27 Rib 28 Reinforcement part 29A-29D Spacer member 30 Plate body 31 Support body 32 Thermocompression bonding part

Claims (11)

A medical administration container for fly larvae or eggs in which a spacer is housed in a bag-shaped bag body,
The surface of the bag body that contacts the affected area is porous,
The spacer is configured to include a frame body or a plate body having a corrugated cross-sectional shape, or a plurality of pieces arranged apart from each other, and at least a part of the spacer exhibits water absorption or in addition to water drainage. Composed of materials,
The fly larvae or egg is characterized in that there is a fly larvae activity space inside the frame or the surface of the plate having a corrugated cross-sectional shape, or at least a space surrounded by the plurality of pieces. Medical dosing container. The medical administration container for fly larvae or eggs according to claim 1, wherein the frame has a flat outer shape. The said spacer is comprised with the material in which at least any one of sodium acrylate, vinyl alcohol, and isopropyl acrylamide was contained with respect to the base | substrate. The fly larva or egg of Claim 1 or 2 characterized by the above-mentioned. Medical dosing container. Each of the plurality of pieces is fixed to the bag body. The medical administration container for fly larvae or eggs according to any one of claims 1 to 3. The medical bag flies larvae or egg according to any one of claims 1 to 4, wherein the bag body has a mesh cloth on one surface contacting the affected part and the other surface. Dosing container. 5. The fly larva or egg according to claim 1, wherein one surface of the bag main body that is in contact with the affected part is made of a mesh cloth, and the other surface is made of a nonwoven fabric. Medical dosing container. In the internal space of the bag-shaped bag body, the contact between one surface of the bag body and the other surface is avoided by the intervention of a spacer housed in the bag body. Item 7. A medical administration container for fly larvae or eggs according to Item 5 or 6. A spacer for a medical administration container for fly larvae or eggs,
It is configured to include a frame or a plate having a corrugated cross-sectional shape, or a plurality of pieces that are spaced apart from each other, and at least a part of the frame is formed of a material that absorbs water or, in addition to this, exhibits drainage. A spacer for a medical administration container for fly larvae or eggs. The spacer for a medical administration container for fly larvae or eggs according to claim 8, wherein the frame has a flat outer shape. The medical fly larvae or egg medical use according to claim 8 or 9, wherein an active space for medical fly larvae exists on the inside of the frame or on the surface of a plate having a corrugated cross-sectional shape. Spacer for administration container. The fly larva according to any one of claims 8 to 10, wherein the spacer is made of a material containing at least one of sodium acrylate, vinyl alcohol, and isopropyl acrylamide with respect to the substrate. Or a spacer for a medical administration container for eggs.

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