JP2009051830A5 - - Google Patents
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- Publication number
- JP2009051830A5 JP2009051830A5 JP2008197142A JP2008197142A JP2009051830A5 JP 2009051830 A5 JP2009051830 A5 JP 2009051830A5 JP 2008197142 A JP2008197142 A JP 2008197142A JP 2008197142 A JP2008197142 A JP 2008197142A JP 2009051830 A5 JP2009051830 A5 JP 2009051830A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- oxo
- dihydro
- dimethyl
- benzoxazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000005843 halogen group Chemical group 0.000 claims 45
- 125000000217 alkyl group Chemical group 0.000 claims 37
- 125000003277 amino group Chemical group 0.000 claims 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 125000002252 acyl group Chemical group 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 8
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 claims 7
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000002950 monocyclic group Chemical group 0.000 claims 7
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 7
- 125000004434 sulfur atoms Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 6
- 230000000051 modifying Effects 0.000 claims 6
- 125000005041 acyloxyalkyl group Chemical group 0.000 claims 5
- 125000005085 alkoxycarbonylalkoxy group Chemical group 0.000 claims 5
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 5
- 150000001408 amides Chemical class 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- 125000004450 alkenylene group Chemical group 0.000 claims 3
- 125000004432 carbon atoms Chemical group C* 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
- -1 aminosulfonylamino group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000005842 heteroatoms Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 150000002829 nitrogen Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 claims 1
- MTXDGZHZKJMCIV-UHFFFAOYSA-N 4-(3-chloro-4-fluorophenyl)-N,2,2-trimethyl-3-oxo-1,4-benzoxazine-7-sulfonamide Chemical compound O=C1C(C)(C)OC2=CC(S(=O)(=O)NC)=CC=C2N1C1=CC=C(F)C(Cl)=C1 MTXDGZHZKJMCIV-UHFFFAOYSA-N 0.000 claims 1
- NGUIGDURHHXIBM-UHFFFAOYSA-N 4-(4-bromophenyl)-N,2,2-trimethyl-3-oxo-1,4-benzoxazine-7-sulfonamide Chemical compound O=C1C(C)(C)OC2=CC(S(=O)(=O)NC)=CC=C2N1C1=CC=C(Br)C=C1 NGUIGDURHHXIBM-UHFFFAOYSA-N 0.000 claims 1
- LDBSBZAUPYKLQE-UHFFFAOYSA-N 4-(4-chloro-2-methylphenyl)-N,2,2-trimethyl-3-oxo-1,4-benzoxazine-7-sulfonamide Chemical compound O=C1C(C)(C)OC2=CC(S(=O)(=O)NC)=CC=C2N1C1=CC=C(Cl)C=C1C LDBSBZAUPYKLQE-UHFFFAOYSA-N 0.000 claims 1
- HEIMKTFCDITCPS-UHFFFAOYSA-N 4-(4-chlorophenyl)-N,2,2-trimethyl-3-oxo-1,4-benzoxazine-7-sulfonamide Chemical compound O=C1C(C)(C)OC2=CC(S(=O)(=O)NC)=CC=C2N1C1=CC=C(Cl)C=C1 HEIMKTFCDITCPS-UHFFFAOYSA-N 0.000 claims 1
- RFLPVGAJJSHVIM-UHFFFAOYSA-N 4-(4-fluoro-3-methylphenyl)-N,2,2-trimethyl-3-oxo-1,4-benzoxazine-7-sulfonamide Chemical compound O=C1C(C)(C)OC2=CC(S(=O)(=O)NC)=CC=C2N1C1=CC=C(F)C(C)=C1 RFLPVGAJJSHVIM-UHFFFAOYSA-N 0.000 claims 1
- ZMAYBSHLWNBTPD-UHFFFAOYSA-N 4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-7-(sulfamoylamino)-1,4-benzoxazine Chemical compound O=C1C(C)(C)OC2=CC(NS(N)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1 ZMAYBSHLWNBTPD-UHFFFAOYSA-N 0.000 claims 1
- KOZIKNCMQPQBKI-UHFFFAOYSA-N 4-(4-fluorophenyl)-N,2,2-trimethyl-3-oxo-1,4-benzoxazine-7-sulfonamide Chemical compound O=C1C(C)(C)OC2=CC(S(=O)(=O)NC)=CC=C2N1C1=CC=C(F)C=C1 KOZIKNCMQPQBKI-UHFFFAOYSA-N 0.000 claims 1
- 201000004304 Addison's disease Diseases 0.000 claims 1
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims 1
- 206010002383 Angina pectoris Diseases 0.000 claims 1
- 206010003119 Arrhythmia Diseases 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- 206010007521 Cardiac arrhythmias Diseases 0.000 claims 1
- 206010007554 Cardiac failure Diseases 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 201000007397 Conn's syndrome Diseases 0.000 claims 1
- 206010011652 Cushing's syndrome Diseases 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010019280 Heart failure Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000010125 Myocardial Infarction Diseases 0.000 claims 1
- 208000009525 Myocarditis Diseases 0.000 claims 1
- ATYVOGGOOLHXQV-UHFFFAOYSA-N N-(2,2-dimethyl-3-oxo-4-phenyl-1,4-benzoxazin-7-yl)methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=CC=C1 ATYVOGGOOLHXQV-UHFFFAOYSA-N 0.000 claims 1
- YFJNRPGWZYLWKG-UHFFFAOYSA-N N-(2,2-dimethyl-3-oxo-4-thiophen-3-yl-1,4-benzoxazin-7-yl)methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C=1C=CSC=1 YFJNRPGWZYLWKG-UHFFFAOYSA-N 0.000 claims 1
- WQFRWOPCQHHOJK-UHFFFAOYSA-N N-(2,2-dimethyl-4-naphthalen-2-yl-3-oxo-1,4-benzoxazin-7-yl)methanesulfonamide Chemical compound C1=CC=CC2=CC(N3C4=CC=C(NS(C)(=O)=O)C=C4OC(C3=O)(C)C)=CC=C21 WQFRWOPCQHHOJK-UHFFFAOYSA-N 0.000 claims 1
- AGNBTCWQAAYCFE-UHFFFAOYSA-N N-(3-oxo-2,4-diphenyl-1,4-benzoxazin-7-yl)methanesulfonamide Chemical compound O1C2=CC(NS(=O)(=O)C)=CC=C2N(C=2C=CC=CC=2)C(=O)C1C1=CC=CC=C1 AGNBTCWQAAYCFE-UHFFFAOYSA-N 0.000 claims 1
- VWYTWYHSCSKCJR-UHFFFAOYSA-N N-(4-benzyl-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl)methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1CC1=CC=CC=C1 VWYTWYHSCSKCJR-UHFFFAOYSA-N 0.000 claims 1
- DQNPWLQDLZFGMB-UHFFFAOYSA-N N-(4-benzyl-3-oxo-1,4-benzoxazin-7-yl)methanesulfonamide Chemical compound O=C1COC2=CC(NS(=O)(=O)C)=CC=C2N1CC1=CC=CC=C1 DQNPWLQDLZFGMB-UHFFFAOYSA-N 0.000 claims 1
- MFKXDYSIJQRAKD-UHFFFAOYSA-N N-[1-(4-fluorophenyl)-3,3-dimethyl-2-oxo-4H-quinoxalin-6-yl]methanesulfonamide Chemical compound O=C1C(C)(C)NC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1 MFKXDYSIJQRAKD-UHFFFAOYSA-N 0.000 claims 1
- DSUOTTACZTWBSI-UHFFFAOYSA-N N-[2,2-diethyl-4-(4-fluorophenyl)-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(CC)(CC)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1 DSUOTTACZTWBSI-UHFFFAOYSA-N 0.000 claims 1
- CCQPXADXOVIECX-UHFFFAOYSA-N N-[2,2-dimethyl-3-oxo-4-(1-phenylethyl)-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C(C)C1=CC=CC=C1 CCQPXADXOVIECX-UHFFFAOYSA-N 0.000 claims 1
- VFMPVKRYUFGJGS-UHFFFAOYSA-N N-[2,2-dimethyl-3-oxo-4-(2,4,6-trifluorophenyl)-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=C(F)C=C(F)C=C1F VFMPVKRYUFGJGS-UHFFFAOYSA-N 0.000 claims 1
- RURJDZSTMFRFMH-UHFFFAOYSA-N N-[2,2-dimethyl-3-oxo-4-(2,4,6-trimethylphenyl)-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O RURJDZSTMFRFMH-UHFFFAOYSA-N 0.000 claims 1
- RGRKYLBLADQINI-UHFFFAOYSA-N N-[2,2-dimethyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=CC(C(F)(F)F)=C1 RGRKYLBLADQINI-UHFFFAOYSA-N 0.000 claims 1
- ZLISRXHFQCGAOK-UHFFFAOYSA-N N-[2,2-dimethyl-3-oxo-4-[5-(trifluoromethyl)pyridin-2-yl]-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(C(F)(F)F)C=N1 ZLISRXHFQCGAOK-UHFFFAOYSA-N 0.000 claims 1
- MTFCBFRLAKCSSS-UHFFFAOYSA-N N-[2,2-dimethyl-4-(3-methyl-5-nitropyridin-2-yl)-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC([N+]([O-])=O)=CN=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O MTFCBFRLAKCSSS-UHFFFAOYSA-N 0.000 claims 1
- VZZYNFHLRWKECI-UHFFFAOYSA-N N-[2,2-dimethyl-4-(4-methylphenyl)-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=CC(C)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O VZZYNFHLRWKECI-UHFFFAOYSA-N 0.000 claims 1
- DSGJRGUZJUNEMX-UHFFFAOYSA-N N-[2,2-dimethyl-4-[(3-methylphenyl)methyl]-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC=CC(CN2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 DSGJRGUZJUNEMX-UHFFFAOYSA-N 0.000 claims 1
- RPQGWOCDHUPBJW-UHFFFAOYSA-N N-[2,2-dimethyl-4-[2-methyl-3-(trifluoromethyl)phenyl]-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=CC=C(C(F)(F)F)C(C)=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O RPQGWOCDHUPBJW-UHFFFAOYSA-N 0.000 claims 1
- WIMXFTNASZVCGC-UHFFFAOYSA-N N-[2,2-dimethyl-4-[2-methyl-4-(trifluoromethyl)phenyl]-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(C(F)(F)F)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O WIMXFTNASZVCGC-UHFFFAOYSA-N 0.000 claims 1
- KEXIQLDXSCQIBH-UHFFFAOYSA-N N-[2,2-dimethyl-4-[2-methyl-5-(trifluoromethyl)phenyl]-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC=C(C(F)(F)F)C=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O KEXIQLDXSCQIBH-UHFFFAOYSA-N 0.000 claims 1
- SOVYPYPQPAHCPB-UHFFFAOYSA-N N-[2,2-dimethyl-4-[2-methyl-5-(trifluoromethyl)pyridin-3-yl]-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=NC=C(C(F)(F)F)C=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O SOVYPYPQPAHCPB-UHFFFAOYSA-N 0.000 claims 1
- ZFERBHYUQJXWNA-UHFFFAOYSA-N N-[2,2-dimethyl-4-[2-methyl-6-(trifluoromethyl)pyridin-3-yl]-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=NC(C(F)(F)F)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O ZFERBHYUQJXWNA-UHFFFAOYSA-N 0.000 claims 1
- FSEJZYCJWFTMKT-UHFFFAOYSA-N N-[2,2-dimethyl-4-[3-methyl-5-(trifluoromethyl)pyridin-2-yl]-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(C(F)(F)F)=CN=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O FSEJZYCJWFTMKT-UHFFFAOYSA-N 0.000 claims 1
- CKXFERIKNRZQDI-UHFFFAOYSA-N N-[2,2-dimethyl-4-[3-methyl-6-(trifluoromethyl)pyridin-2-yl]-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC=C(C(F)(F)F)N=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O CKXFERIKNRZQDI-UHFFFAOYSA-N 0.000 claims 1
- VZPXTTBDQSVIOH-UHFFFAOYSA-N N-[2-ethyl-4-(4-fluorophenyl)-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(CC)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1 VZPXTTBDQSVIOH-UHFFFAOYSA-N 0.000 claims 1
- NWGBZVWHKQRCLJ-UHFFFAOYSA-N N-[4-(1-benzofuran-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=CC=C2OC(N3C4=CC=C(NS(C)(=O)=O)C=C4OC(C3=O)(C)C)=CC2=C1 NWGBZVWHKQRCLJ-UHFFFAOYSA-N 0.000 claims 1
- ZUPAVTMPLLCWMF-UHFFFAOYSA-N N-[4-(1-benzothiophen-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=CC=C2SC(N3C4=CC=C(NS(C)(=O)=O)C=C4OC(C3=O)(C)C)=CC2=C1 ZUPAVTMPLLCWMF-UHFFFAOYSA-N 0.000 claims 1
- KDGHNRYGWHALJG-UHFFFAOYSA-N N-[4-(2,2-difluoro-1,3-benzodioxol-5-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C2OC(F)(F)OC2=CC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C2=O)(C)C)=C1 KDGHNRYGWHALJG-UHFFFAOYSA-N 0.000 claims 1
- OHHHZZASSVEOKO-UHFFFAOYSA-N N-[4-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C2OC(F)(F)OC2=CC(N2C3=C(F)C=C(NS(C)(=O)=O)C=C3OC(C2=O)(C)C)=C1 OHHHZZASSVEOKO-UHFFFAOYSA-N 0.000 claims 1
- HCZMMNCGZMTTPF-UHFFFAOYSA-N N-[4-(2,4-difluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1F HCZMMNCGZMTTPF-UHFFFAOYSA-N 0.000 claims 1
- KAKJTCAWZITCRW-UHFFFAOYSA-N N-[4-(2,4-dimethylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(C)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O KAKJTCAWZITCRW-UHFFFAOYSA-N 0.000 claims 1
- QEBANAIUHHBPKZ-UHFFFAOYSA-N N-[4-(2,6-dimethylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC=CC(C)=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O QEBANAIUHHBPKZ-UHFFFAOYSA-N 0.000 claims 1
- QBCTVTPLKYRFTB-UHFFFAOYSA-N N-[4-(2,6-dimethylpyridin-3-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=NC(C)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O QBCTVTPLKYRFTB-UHFFFAOYSA-N 0.000 claims 1
- YZHORZNFKHNXGP-UHFFFAOYSA-N N-[4-(2-chloro-4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1Cl YZHORZNFKHNXGP-UHFFFAOYSA-N 0.000 claims 1
- UZTWFWMQJKMFGG-UHFFFAOYSA-N N-[4-(3,4-dichlorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Cl)C(Cl)=C1 UZTWFWMQJKMFGG-UHFFFAOYSA-N 0.000 claims 1
- GDHKTMBRBGKYBF-UHFFFAOYSA-N N-[4-(3,4-difluoro-5-methoxyphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound FC1=C(F)C(OC)=CC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 GDHKTMBRBGKYBF-UHFFFAOYSA-N 0.000 claims 1
- MJQZMKFQPPIGOP-UHFFFAOYSA-N N-[4-(3,4-difluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C(F)=C1 MJQZMKFQPPIGOP-UHFFFAOYSA-N 0.000 claims 1
- BZRJGEVCVBMCKQ-UHFFFAOYSA-N N-[4-(3,4-difluorophenyl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(F)C(F)=C1 BZRJGEVCVBMCKQ-UHFFFAOYSA-N 0.000 claims 1
- RZXLCYBUVRBKQO-UHFFFAOYSA-N N-[4-(3,5-dichloropyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=NC=C(Cl)C=C1Cl RZXLCYBUVRBKQO-UHFFFAOYSA-N 0.000 claims 1
- OLNQRBMEQJZHEX-UHFFFAOYSA-N N-[4-(3-amino-4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C(N)=C1 OLNQRBMEQJZHEX-UHFFFAOYSA-N 0.000 claims 1
- NEOKGNXNEJFMED-UHFFFAOYSA-N N-[4-(3-chloro-2-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=C(Cl)C=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O NEOKGNXNEJFMED-UHFFFAOYSA-N 0.000 claims 1
- PUZREFPSLMBXJJ-UHFFFAOYSA-N N-[4-(3-chloro-4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C(Cl)=C1 PUZREFPSLMBXJJ-UHFFFAOYSA-N 0.000 claims 1
- YZDMNJNQEVMZOR-UHFFFAOYSA-N N-[4-(3-chloro-4-fluorophenyl)-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1COC2=CC(NS(=O)(=O)C)=CC=C2N1C1=CC=C(F)C(Cl)=C1 YZDMNJNQEVMZOR-UHFFFAOYSA-N 0.000 claims 1
- ZQTOBTSSFSJVGW-UHFFFAOYSA-N N-[4-(3-chloro-4-fluorophenyl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(F)C(Cl)=C1 ZQTOBTSSFSJVGW-UHFFFAOYSA-N 0.000 claims 1
- CUFZJIZVCUYWMA-UHFFFAOYSA-N N-[4-(3-chloro-4-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(Cl)C(C)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O CUFZJIZVCUYWMA-UHFFFAOYSA-N 0.000 claims 1
- YHCAOUGIXOEZHE-UHFFFAOYSA-N N-[4-(3-chlorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=CC(Cl)=C1 YHCAOUGIXOEZHE-UHFFFAOYSA-N 0.000 claims 1
- WZQDLLOYHQZDSZ-UHFFFAOYSA-N N-[4-(3-chlorophenyl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=CC(Cl)=C1 WZQDLLOYHQZDSZ-UHFFFAOYSA-N 0.000 claims 1
- OHYPCALFNZQIAU-UHFFFAOYSA-N N-[4-(3-fluoro-4-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(F)C(C)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O OHYPCALFNZQIAU-UHFFFAOYSA-N 0.000 claims 1
- SAPKVGPWRVZGST-UHFFFAOYSA-N N-[4-(4-bromo-2-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(Br)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O SAPKVGPWRVZGST-UHFFFAOYSA-N 0.000 claims 1
- VAYOPXFXNATCRB-UHFFFAOYSA-N N-[4-(4-bromo-3-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(Br)C(C)=CC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 VAYOPXFXNATCRB-UHFFFAOYSA-N 0.000 claims 1
- JMTWDECFVHTGCS-UHFFFAOYSA-N N-[4-(4-bromophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Br)C=C1 JMTWDECFVHTGCS-UHFFFAOYSA-N 0.000 claims 1
- ZYVJRBNHRSDWOT-UHFFFAOYSA-N N-[4-(4-chloro-2,6-dimethylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(Cl)=CC(C)=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O ZYVJRBNHRSDWOT-UHFFFAOYSA-N 0.000 claims 1
- ICCMXUAEXLQZMB-UHFFFAOYSA-N N-[4-(4-chloro-2-cyanophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Cl)C=C1C#N ICCMXUAEXLQZMB-UHFFFAOYSA-N 0.000 claims 1
- SVTXCXNRBLTGTJ-UHFFFAOYSA-N N-[4-(4-chloro-2-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Cl)C=C1F SVTXCXNRBLTGTJ-UHFFFAOYSA-N 0.000 claims 1
- UBPQFURJBJVCIB-UHFFFAOYSA-N N-[4-(4-chloro-2-fluorophenyl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(Cl)C=C1F UBPQFURJBJVCIB-UHFFFAOYSA-N 0.000 claims 1
- JEGBIILLTBMLOD-UHFFFAOYSA-N N-[4-(4-chloro-2-methoxy-5-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound COC1=CC(Cl)=C(C)C=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O JEGBIILLTBMLOD-UHFFFAOYSA-N 0.000 claims 1
- HYXYZRZUDVQKES-UHFFFAOYSA-N N-[4-(4-chloro-2-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(Cl)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O HYXYZRZUDVQKES-UHFFFAOYSA-N 0.000 claims 1
- DEDWQNYAFHYNMU-UHFFFAOYSA-N N-[4-(4-chloro-2-methylphenyl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(Cl)=CC=C1N1C2=C(F)C=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O DEDWQNYAFHYNMU-UHFFFAOYSA-N 0.000 claims 1
- BUHXPSJBBLSISZ-UHFFFAOYSA-N N-[4-(4-chloro-3-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Cl)C(F)=C1 BUHXPSJBBLSISZ-UHFFFAOYSA-N 0.000 claims 1
- DGYRXAKRFHFIEQ-UHFFFAOYSA-N N-[4-(4-chloro-3-methoxyphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(Cl)C(OC)=CC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 DGYRXAKRFHFIEQ-UHFFFAOYSA-N 0.000 claims 1
- UYRQOXKKTGTCJY-UHFFFAOYSA-N N-[4-(4-chloro-3-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(Cl)C(C)=CC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 UYRQOXKKTGTCJY-UHFFFAOYSA-N 0.000 claims 1
- BZJIWSMYBQWCIK-UHFFFAOYSA-N N-[4-(4-chlorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Cl)C=C1 BZJIWSMYBQWCIK-UHFFFAOYSA-N 0.000 claims 1
- AVYWHGPDVRHBOT-UHFFFAOYSA-N N-[4-(4-chlorophenyl)-3-oxo-2-phenyl-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O1C2=CC(NS(=O)(=O)C)=CC=C2N(C=2C=CC(Cl)=CC=2)C(=O)C1C1=CC=CC=C1 AVYWHGPDVRHBOT-UHFFFAOYSA-N 0.000 claims 1
- CKBPENISECEQLA-UHFFFAOYSA-N N-[4-(4-chlorophenyl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(Cl)C=C1 CKBPENISECEQLA-UHFFFAOYSA-N 0.000 claims 1
- MBRYVKYBJDKKFT-UHFFFAOYSA-N N-[4-(4-fluoro-2,3-dimethylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=C(F)C=CC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1C MBRYVKYBJDKKFT-UHFFFAOYSA-N 0.000 claims 1
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- GQRUOIYHWYBNGH-UHFFFAOYSA-N N-[4-(4-fluoro-2-methoxyphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound COC1=CC(F)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O GQRUOIYHWYBNGH-UHFFFAOYSA-N 0.000 claims 1
- LCTQKOFETXMWBW-UHFFFAOYSA-N N-[4-(4-fluoro-2-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(F)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O LCTQKOFETXMWBW-UHFFFAOYSA-N 0.000 claims 1
- IPAMUWRVCLNZQC-UHFFFAOYSA-N N-[4-(4-fluoro-3-methoxyphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(F)C(OC)=CC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 IPAMUWRVCLNZQC-UHFFFAOYSA-N 0.000 claims 1
- HXPOTUNYNZJYMY-UHFFFAOYSA-N N-[4-(4-fluoro-3-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(F)C(C)=CC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 HXPOTUNYNZJYMY-UHFFFAOYSA-N 0.000 claims 1
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- OENXFOMMTVWVMH-UHFFFAOYSA-N N-[4-(4-fluorophenyl)-2,2,6-trimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC=2C=C(NS(C)(=O)=O)C(C)=CC=2N1C1=CC=C(F)C=C1 OENXFOMMTVWVMH-UHFFFAOYSA-N 0.000 claims 1
- GQZGJKDFWXFXNR-UHFFFAOYSA-N N-[4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]ethanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(=O)(=O)CC)=CC=C2N1C1=CC=C(F)C=C1 GQZGJKDFWXFXNR-UHFFFAOYSA-N 0.000 claims 1
- AZNHWXAFPBYFGH-UHFFFAOYSA-N N-[4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1 AZNHWXAFPBYFGH-UHFFFAOYSA-N 0.000 claims 1
- JVEMUICGJFZBAS-UHFFFAOYSA-N N-[4-(4-fluorophenyl)-2,2-dimethyl-3-sulfanylidene-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound S=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1 JVEMUICGJFZBAS-UHFFFAOYSA-N 0.000 claims 1
- WPZPTJCDAZMPKJ-UHFFFAOYSA-N N-[4-(4-fluorophenyl)-2,2-dimethyl-3H-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C12=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)CN1C1=CC=C(F)C=C1 WPZPTJCDAZMPKJ-UHFFFAOYSA-N 0.000 claims 1
- RPRLNYNIMTUMNA-UHFFFAOYSA-N N-[4-(4-fluorophenyl)-2-methyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1 RPRLNYNIMTUMNA-UHFFFAOYSA-N 0.000 claims 1
- ROEPZBMDDYZAQO-UHFFFAOYSA-N N-[4-(4-fluorophenyl)-3-oxo-2-phenyl-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O1C2=CC(NS(=O)(=O)C)=CC=C2N(C=2C=CC(F)=CC=2)C(=O)C1C1=CC=CC=C1 ROEPZBMDDYZAQO-UHFFFAOYSA-N 0.000 claims 1
- UMCADXBBKQPBAP-UHFFFAOYSA-N N-[4-(4-fluorophenyl)-3-oxospiro[1,4-benzoxazine-2,1'-cyclobutane]-7-yl]methanesulfonamide Chemical compound O1C2=CC(NS(=O)(=O)C)=CC=C2N(C=2C=CC(F)=CC=2)C(=O)C21CCC2 UMCADXBBKQPBAP-UHFFFAOYSA-N 0.000 claims 1
- JTPJYSHKGSUFOC-UHFFFAOYSA-N N-[4-(4-fluorophenyl)-3-oxospiro[1,4-benzoxazine-2,1'-cyclopropane]-7-yl]methanesulfonamide Chemical compound O1C2=CC(NS(=O)(=O)C)=CC=C2N(C=2C=CC(F)=CC=2)C(=O)C21CC2 JTPJYSHKGSUFOC-UHFFFAOYSA-N 0.000 claims 1
- YBLSHFYILYNOLB-UHFFFAOYSA-N N-[4-(4-methoxyphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=CC(OC)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O YBLSHFYILYNOLB-UHFFFAOYSA-N 0.000 claims 1
- FKOBAKQERRMALM-UHFFFAOYSA-N N-[4-(5-bromo-3-methylpyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(Br)=CN=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O FKOBAKQERRMALM-UHFFFAOYSA-N 0.000 claims 1
- TXIWJYZPYQFJAY-UHFFFAOYSA-N N-[4-(5-bromo-3-methylpyridin-2-yl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(Br)=CN=C1N1C2=C(F)C=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O TXIWJYZPYQFJAY-UHFFFAOYSA-N 0.000 claims 1
- IFKWZONILQABOE-UHFFFAOYSA-N N-[4-(5-bromo-6-methylpyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(Br)C(C)=NC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 IFKWZONILQABOE-UHFFFAOYSA-N 0.000 claims 1
- RFIPREZIXWKBPZ-UHFFFAOYSA-N N-[4-(5-bromopyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Br)C=N1 RFIPREZIXWKBPZ-UHFFFAOYSA-N 0.000 claims 1
- UNFFEIKCAIQGAS-UHFFFAOYSA-N N-[4-(5-bromopyridin-2-yl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(Br)C=N1 UNFFEIKCAIQGAS-UHFFFAOYSA-N 0.000 claims 1
- MEVWVGKEYKSRCF-UHFFFAOYSA-N N-[4-(5-chloro-2-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC=C(Cl)C=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O MEVWVGKEYKSRCF-UHFFFAOYSA-N 0.000 claims 1
- FKVOMJUKSNCPBH-UHFFFAOYSA-N N-[4-(5-chloro-3-fluoropyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=NC=C(Cl)C=C1F FKVOMJUKSNCPBH-UHFFFAOYSA-N 0.000 claims 1
- OBVQFKMVNANJQJ-UHFFFAOYSA-N N-[4-(5-chloro-3-fluoropyridin-2-yl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=NC=C(Cl)C=C1F OBVQFKMVNANJQJ-UHFFFAOYSA-N 0.000 claims 1
- PUJQHYYZGNXQAO-UHFFFAOYSA-N N-[4-(5-chloro-3-methylpyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(Cl)=CN=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O PUJQHYYZGNXQAO-UHFFFAOYSA-N 0.000 claims 1
- GIBDAYXHTKEFGF-UHFFFAOYSA-N N-[4-(5-chloro-3-methylpyridin-2-yl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(Cl)=CN=C1N1C2=C(F)C=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O GIBDAYXHTKEFGF-UHFFFAOYSA-N 0.000 claims 1
- KHGMJWTXYMIEOH-UHFFFAOYSA-N N-[4-(5-chloropyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Cl)C=N1 KHGMJWTXYMIEOH-UHFFFAOYSA-N 0.000 claims 1
- OASITQYOGCLLGS-UHFFFAOYSA-N N-[4-(5-chloropyridin-2-yl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(Cl)C=N1 OASITQYOGCLLGS-UHFFFAOYSA-N 0.000 claims 1
- VQYMDHTXCLQZAO-UHFFFAOYSA-N N-[4-(5-chlorothiophen-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Cl)S1 VQYMDHTXCLQZAO-UHFFFAOYSA-N 0.000 claims 1
- TXWCXGICNOPUAM-UHFFFAOYSA-N N-[4-(5-fluoro-2-methylphenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC=C(F)C=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O TXWCXGICNOPUAM-UHFFFAOYSA-N 0.000 claims 1
- LCZUPQNBPXTKHX-UHFFFAOYSA-N N-[4-(5-fluoro-3-methylpyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(F)=CN=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O LCZUPQNBPXTKHX-UHFFFAOYSA-N 0.000 claims 1
- QZNOECUFKPPIEZ-UHFFFAOYSA-N N-[4-(5-fluoro-6-methylpyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(F)C(C)=NC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 QZNOECUFKPPIEZ-UHFFFAOYSA-N 0.000 claims 1
- HKISGTFNZLKHJJ-UHFFFAOYSA-N N-[4-(5-fluoropyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=N1 HKISGTFNZLKHJJ-UHFFFAOYSA-N 0.000 claims 1
- LIPKIBXUWPHMHG-UHFFFAOYSA-N N-[4-(6-bromo-5-methylpyridin-3-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound N1=C(Br)C(C)=CC(N2C3=CC=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 LIPKIBXUWPHMHG-UHFFFAOYSA-N 0.000 claims 1
- OTSQIOYYVANWPF-UHFFFAOYSA-N N-[4-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C(C(=C1)Cl)=CC2=C1OC(F)(F)O2 OTSQIOYYVANWPF-UHFFFAOYSA-N 0.000 claims 1
- BXADFZDBDCEJKT-UHFFFAOYSA-N N-[4-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C(C(=C1)Cl)=CC2=C1OC(F)(F)O2 BXADFZDBDCEJKT-UHFFFAOYSA-N 0.000 claims 1
- SIJGUHDKUGHHKM-UHFFFAOYSA-N N-[4-(6-chloro-2-methylpyridin-3-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=NC(Cl)=CC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O SIJGUHDKUGHHKM-UHFFFAOYSA-N 0.000 claims 1
- CWBPAUOUWHIBMP-UHFFFAOYSA-N N-[4-(6-chloro-2-methylpyridin-3-yl)-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=NC(Cl)=CC=C1N1C2=C(F)C=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O CWBPAUOUWHIBMP-UHFFFAOYSA-N 0.000 claims 1
- WAPLBKWHOPNPHK-UHFFFAOYSA-N N-[4-(6-chloro-4-methylpyridin-3-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(Cl)=NC=C1N1C2=CC=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O WAPLBKWHOPNPHK-UHFFFAOYSA-N 0.000 claims 1
- VDHIXWBXXRDEJX-UHFFFAOYSA-N N-[4-[2-chloro-6-(trifluoromethyl)pyridin-3-yl]-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(C(F)(F)F)N=C1Cl VDHIXWBXXRDEJX-UHFFFAOYSA-N 0.000 claims 1
- OCUZWMHXNNOWDE-UHFFFAOYSA-N N-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=NC=C(C(F)(F)F)C=C1Cl OCUZWMHXNNOWDE-UHFFFAOYSA-N 0.000 claims 1
- WATCGLCDQNHAIW-UHFFFAOYSA-N N-[4-[3-fluoro-4-(trifluoromethyl)phenyl]-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(C(F)(F)F)C(F)=C1 WATCGLCDQNHAIW-UHFFFAOYSA-N 0.000 claims 1
- JXFFKJUUFUZNHJ-UHFFFAOYSA-N N-[4-[4-chloro-3-(hydroxymethyl)phenyl]-5-fluoro-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(Cl)C(CO)=C1 JXFFKJUUFUZNHJ-UHFFFAOYSA-N 0.000 claims 1
- JWGKEFBPDDKLBN-UHFFFAOYSA-N N-[4-[4-chloro-3-(trifluoromethyl)phenyl]-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(Cl)C(C(F)(F)F)=C1 JWGKEFBPDDKLBN-UHFFFAOYSA-N 0.000 claims 1
- VMNMPPZUZYEQND-UHFFFAOYSA-N N-[4-[4-fluoro-2-(trifluoromethyl)phenyl]-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C1=CC=C(F)C=C1C(F)(F)F VMNMPPZUZYEQND-UHFFFAOYSA-N 0.000 claims 1
- COMPGKMCZRAZLO-UHFFFAOYSA-N N-[5-bromo-4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(Br)=C2N1C1=CC=C(F)C=C1 COMPGKMCZRAZLO-UHFFFAOYSA-N 0.000 claims 1
- YIIWRWHPFKBNFY-UHFFFAOYSA-N N-[5-chloro-4-(4-chlorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(Cl)=C2N1C1=CC=C(Cl)C=C1 YIIWRWHPFKBNFY-UHFFFAOYSA-N 0.000 claims 1
- SJAVZOLSACOREQ-UHFFFAOYSA-N N-[5-chloro-4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(Cl)=C2N1C1=CC=C(F)C=C1 SJAVZOLSACOREQ-UHFFFAOYSA-N 0.000 claims 1
- BKRPHJXCIBRPMV-UHFFFAOYSA-N N-[5-cyclopropyl-4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C=12N(C=3C=CC(F)=CC=3)C(=O)C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=1C1CC1 BKRPHJXCIBRPMV-UHFFFAOYSA-N 0.000 claims 1
- NKVRPMFMLKUTQY-UHFFFAOYSA-N N-[5-ethenyl-4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(C=C)=C2N1C1=CC=C(F)C=C1 NKVRPMFMLKUTQY-UHFFFAOYSA-N 0.000 claims 1
- DFVBINFLRWQGOA-UHFFFAOYSA-N N-[5-ethyl-4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=2C(CC)=CC(NS(C)(=O)=O)=CC=2OC(C)(C)C(=O)N1C1=CC=C(F)C=C1 DFVBINFLRWQGOA-UHFFFAOYSA-N 0.000 claims 1
- XLUNNXRXDXEEDS-UHFFFAOYSA-N N-[5-fluoro-2,2-dimethyl-3-oxo-4-[4-(trifluoromethyl)phenyl]-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(C(F)(F)F)C=C1 XLUNNXRXDXEEDS-UHFFFAOYSA-N 0.000 claims 1
- ICNQEUWEQHZYIM-UHFFFAOYSA-N N-[5-fluoro-2,2-dimethyl-3-oxo-4-[5-(trifluoromethyl)pyridin-2-yl]-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(C(F)(F)F)C=N1 ICNQEUWEQHZYIM-UHFFFAOYSA-N 0.000 claims 1
- MKNYQNVFTARMPG-UHFFFAOYSA-N N-[5-fluoro-2,2-dimethyl-3-oxo-4-[5-(trifluoromethyl)thiophen-2-yl]-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(C(F)(F)F)S1 MKNYQNVFTARMPG-UHFFFAOYSA-N 0.000 claims 1
- OSVBGKNJWDHJNR-UHFFFAOYSA-N N-[5-fluoro-2,2-dimethyl-4-[3-methyl-5-(trifluoromethyl)pyridin-2-yl]-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(C(F)(F)F)=CN=C1N1C2=C(F)C=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O OSVBGKNJWDHJNR-UHFFFAOYSA-N 0.000 claims 1
- MSVRWYSNXOEQND-UHFFFAOYSA-N N-[5-fluoro-4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(F)C=C1 MSVRWYSNXOEQND-UHFFFAOYSA-N 0.000 claims 1
- QSTUKNUIEWAJCH-UHFFFAOYSA-N N-[5-fluoro-4-(5-fluoro-3-methylpyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound CC1=CC(F)=CN=C1N1C2=C(F)C=C(NS(C)(=O)=O)C=C2OC(C)(C)C1=O QSTUKNUIEWAJCH-UHFFFAOYSA-N 0.000 claims 1
- BANBPNJJDWKWEZ-UHFFFAOYSA-N N-[5-fluoro-4-(5-fluoro-6-methylpyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound C1=C(F)C(C)=NC(N2C3=C(F)C=C(NS(C)(=O)=O)C=C3OC(C)(C)C2=O)=C1 BANBPNJJDWKWEZ-UHFFFAOYSA-N 0.000 claims 1
- UUUZUIXQKXSDNG-UHFFFAOYSA-N N-[5-fluoro-4-(5-fluoropyridin-2-yl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(F)C=N1 UUUZUIXQKXSDNG-UHFFFAOYSA-N 0.000 claims 1
- SYYWQUOOZXNZLQ-UHFFFAOYSA-N N-[5-fluoro-4-[3-fluoro-4-(trifluoromethyl)phenyl]-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(C(F)(F)F)C(F)=C1 SYYWQUOOZXNZLQ-UHFFFAOYSA-N 0.000 claims 1
- RVSIOCARSPNOGX-UHFFFAOYSA-N N-[5-fluoro-4-[4-fluoro-3-(trifluoromethyl)phenyl]-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC(F)=C2N1C1=CC=C(F)C(C(F)(F)F)=C1 RVSIOCARSPNOGX-UHFFFAOYSA-N 0.000 claims 1
- IZIGMZJUGXLQDA-UHFFFAOYSA-N N-[6-amino-4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=C(N)C=C2N1C1=CC=C(F)C=C1 IZIGMZJUGXLQDA-UHFFFAOYSA-N 0.000 claims 1
- 210000001774 Pressoreceptors Anatomy 0.000 claims 1
- 206010039808 Secondary aldosteronism Diseases 0.000 claims 1
- AFHGWYBJHLGLFT-UHFFFAOYSA-N [2-chloro-5-[7-(methanesulfonamido)-2,2-dimethyl-3-oxo-1,4-benzoxazin-4-yl]phenyl]methyl benzoate Chemical compound O=C1C(C)(C)OC2=CC(NS(C)(=O)=O)=CC=C2N1C(C=1)=CC=C(Cl)C=1COC(=O)C1=CC=CC=C1 AFHGWYBJHLGLFT-UHFFFAOYSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 229960002478 aldosterone Drugs 0.000 claims 1
- 239000002170 aldosterone antagonist Substances 0.000 claims 1
- 125000005236 alkanoylamino group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 230000001396 anti-anti-diuretic Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 108091008020 baroreceptors Proteins 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 230000001882 diuretic Effects 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 230000002107 myocardial Effects 0.000 claims 1
- 108091007893 nuclear steroid hormone receptors Proteins 0.000 claims 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 201000010874 syndrome Diseases 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Claims (19)
環Aはベンゼン環又は含窒素6員芳香族複素環[当該ベンゼン環又は含窒素6員芳香族複素環は、R 11 以外にも(a)ハロゲン原子、(b)アルキル基(該アルキル基はハロゲン原子、水酸基、アルコキシ基、アミノ基、モノアルキルアミノ基及びジアルキルアミノ基から選ばれる基で置換されていてもよい)、(c)水酸基、(d)アルコキシ基、(e)アミノ基(該アミノ基はアルキル基及びアシル基から選ばれる1〜2個の基で置換されていてもよい)、(f)シアノ基、(g)カルボキシル基、(h)アルコキシカルボニル基、(i)アルケニル基(該アルケニル基はアルコキシ基で置換されていてもよい)、(j)アルカノイル基、(k)シクロアルキル基および(l)カルバモイル基(該カルバモイル基は1〜2個のアルキル基で置換されていてもよい)から選ばれる同一もしくは異なる1〜3個の置換基を有していてもよい]、
R1は式:RaSO2NH−、RaSO2NH−CH2−又は(Rb)(Rc)NSO2−で示される基、
Raは(1)アルキル基、(2)シクロアルキル基、(3)アルキル基で置換されていてもよいアミノ基、(4)6〜10員単環式もしくは二環式アリール基〔該アリール基はa)ハロゲン原子、b)水酸基、c)1〜3個のハロゲン原子で置換されていてもよいアルキル基、d)ヒドロキシアルキル基、e)アシルオキシアルキル基、f)1〜3個のハロゲン原子で置換されていてもよいアルコキシ基、g)アルコキシカルボニルアルコキシ基、h)アルキルチオ基、i)1〜2個のハロゲン原子で置換されていてもよいアルキレンジオキシ基、j)1〜2個のアルキル基で置換されていてもよいアミノ基、k)アシル基で置換されたアミノ基、l)シクロアルキル基及びm)アルキルスルホニル基から選ばれる1〜3個の基で置換されていてもよい〕又は(5)酸素原子、硫黄原子及び窒素原子から選ばれる1〜3個の異項原子を含む5〜10員単環式もしくは二環式ヘテロアリール基〔該へテロアリール基はa)ハロゲン原子、b)水酸基、c)1〜3個のハロゲン原子で置換されていてもよいアルキル基、d)ヒドロキシアルキル基、e)アシルオキシアルキル基、f)1〜3個のハロゲン原子で置換されていてもよいアルコキシ基、g)アルコキシカルボニルアルコキシ基、h)アルキルチオ基、i)1〜2個のハロゲン原子で置換されていてもよいアルキレンジオキシ基、j)1〜2個のアルキル基で置換されていてもよいアミノ基、k)アシル基で置換されたアミノ基、l)シクロアルキル基及びm)アルキルスルホニル基から選ばれる1〜3個の基で置換されていてもよい〕、
Rb及びRcは同一又は異なって水素原子、アルキル基又はシクロアルキル基、
R2及びR3は同一又は異なって水素原子、ハロゲン原子、アルキル基、アルケニル基、カルボキシル基、アルコキシカルボニル基、カルバモイル基又は1〜2個のハロゲン原子で置換されていてもよい6〜10員単環式もしくは二環式アリール基であるか、或いは両者が互いに結合して隣接炭素原子と共にa)シクロアルキル基、b)シクロアルケニル基及びc)飽和もしくは不飽和5〜8員含窒素、含酸素もしくは含硫単環式複素環式基から選ばれる飽和もしくは不飽和環式基を形成し、
Xは酸素原子、硫黄原子、メチレン基又は式:−NR4−で示される基、
R4は水素原子、アルキル基、ハロゲン原子で置換されていてもよいアラルキル基又はアシル基、
Yは式:−C(=O)−、−C(=S)−又は−CH(R5)−で示される基、
R5は水素原子、アルキル基又は置換されていてもよい6〜10員単環式もしくは二環式アリール基(該アリール基は1〜2個のハロゲン原子で置換されていてもよい)、
Arは(1)6〜10員単環式もしくは二環式アリール基〔該アリール基はa)ハロゲン原子、b)水酸基、c)1〜3個のハロゲン原子で置換されていてもよいアルキル基、d)ヒドロキシアルキル基、e)アシルオキシアルキル基、f)1〜3個のハロゲン原子で置換されていてもよいアルコキシ基、g)アルコキシカルボニルアルコキシ基、h)アルキルチオ基、i)1〜2個のハロゲン原子で置換されていてもよいアルキレンジオキシ基、j)1〜2個のアルキル基で置換されていてもよいアミノ基、k)アシル基で置換されたアミノ基、l)シクロアルキル基及びm)アルキルスルホニル基から選ばれる1〜3個の基で置換されていてもよい〕又は(2)酸素原子、硫黄原子及び窒素原子から選ばれる1〜3個の異項原子を含む5〜10員単環式もしくは二環式ヘテロアリール基〔該へテロアリール基はa)ハロゲン原子、b)水酸基、c)1〜3個のハロゲン原子で置換されていてもよいアルキル基、d)ヒドロキシアルキル基、e)アシルオキシアルキル基、f)1〜3個のハロゲン原子で置換されていてもよいアルコキシ基、g)アルコキシカルボニルアルコキシ基、h)アルキルチオ基、i)1〜2個のハロゲン原子で置換されていてもよいアルキレンジオキシ基、j)1〜2個のアルキル基で置換されていてもよいアミノ基、k)アシル基で置換されたアミノ基、l)シクロアルキル基及びm)アルキルスルホニル基から選ばれる1〜3個の基で置換されていてもよい〕、
Qは単結合手、アルキレン基又はアルケニレン基
を表す。]
で示される化合物又はその薬理的に許容し得る塩を有効成分としてなる医薬組成物。 Formula [I]:
Ring A is a benzene ring or a nitrogen-containing 6-membered aromatic heterocycle [the benzene ring or nitrogen-containing 6-membered aromatic heterocycle includes, in addition to R 11 , (a) a halogen atom, (b) an alkyl group (the alkyl group Optionally substituted with a group selected from a halogen atom, a hydroxyl group, an alkoxy group, an amino group, a monoalkylamino group and a dialkylamino group), (c) a hydroxyl group, (d) an alkoxy group, (e) an amino group The amino group may be substituted with one or two groups selected from an alkyl group and an acyl group), (f) a cyano group, (g) a carboxyl group, (h) an alkoxycarbonyl group, and (i) an alkenyl group. (The alkenyl group may be substituted with an alkoxy group), (j) an alkanoyl group, (k) a cycloalkyl group, and (l) a carbamoyl group (the carbamoyl group is one to two alkyl groups). In may have the same or different 1 to 3 substituents selected from the may be) Replace,
R 1 is a group represented by the formula: R a SO 2 NH—, R a SO 2 NH—CH 2 — or (R b ) (R c ) NSO 2 —,
R a is (1) an alkyl group, (2) a cycloalkyl group, (3) an amino group optionally substituted with an alkyl group, (4) a 6 to 10-membered monocyclic or bicyclic aryl group [the aryl The groups are a) a halogen atom, b) a hydroxyl group, c) an alkyl group optionally substituted with 1 to 3 halogen atoms, d) a hydroxyalkyl group, e) an acyloxyalkyl group, f) 1 to 3 halogens An alkoxy group optionally substituted with atoms, g) an alkoxycarbonylalkoxy group, h) an alkylthio group, i) an alkylenedioxy group optionally substituted with 1 to 2 halogen atoms, j) 1 to 2 An amino group optionally substituted with an alkyl group, k) an amino group substituted with an acyl group, 1) a cycloalkyl group, and m) an alkylsulfonyl group. It may be] or (5) an oxygen atom, 5- to 10-membered monocyclic or heteroaryl groups bicyclic heteroaryl group [said containing 1-3 hetero atoms selected from sulfur atom and a nitrogen atom a) a halogen atom, b) a hydroxyl group, c) an alkyl group optionally substituted by 1 to 3 halogen atoms, d) a hydroxyalkyl group, e) an acyloxyalkyl group, f) 1 to 3 halogen atoms An optionally substituted alkoxy group, g) an alkoxycarbonylalkoxy group, h) an alkylthio group, i) an alkylenedioxy group optionally substituted with 1 to 2 halogen atoms, j) 1 to 2 alkyls An amino group which may be substituted with a group, k) an amino group substituted with an acyl group, 1) a cycloalkyl group, and m) a substituted group with 1 to 3 groups selected from an alkylsulfonyl group. May be],
R b and R c are the same or different and each represents a hydrogen atom, an alkyl group or a cycloalkyl group,
R 2 and R 3 are the same or different and each represents a hydrogen atom, a halogen atom, A alkyl group, an alkenyl group, a carboxyl group, an alkoxycarbonyl group, may be substituted mosquito Rubamoiru groups or with one to two halogen atoms 6 A 10-membered monocyclic or bicyclic aryl group, or both of them bonded to each other, together with adjacent carbon atoms, a) a cycloalkyl group, b) a cycloalkenyl group and c) a saturated or unsaturated 5-8 member nitrogen, saturated or unsaturated cyclic group selected from oxygen-containing or sulfur-containing monocyclic heterocyclic group form shape,
X is an oxygen atom, a sulfur atom, a methylene group or a group represented by the formula: —NR 4 —;
R 4 represents a hydrogen atom, an alkyl group, an aralkyl group or an acyl group which may be substituted with a halogen atom ,
Y is a group represented by the formula: —C (═O) —, —C (═S) — or —CH (R 5 ) —,
R 5 is a hydrogen atom, an alkyl group, or an optionally substituted 6 to 10-membered monocyclic or bicyclic aryl group (the aryl group may be substituted with 1 to 2 halogen atoms) ,
Ar is (1) a 6 to 10-membered monocyclic or bicyclic aryl group (the aryl group is a) a halogen atom, b) a hydroxyl group, and c) an alkyl group optionally substituted by 1 to 3 halogen atoms. D) hydroxyalkyl group, e) acyloxyalkyl group, f) alkoxy group optionally substituted by 1 to 3 halogen atoms, g) alkoxycarbonylalkoxy group, h) alkylthio group, i) 1 to 2 An alkylenedioxy group optionally substituted with a halogen atom, j) an amino group optionally substituted with 1 to 2 alkyl groups, k) an amino group substituted with an acyl group, l) a cycloalkyl group and m) optionally substituted with 1 to 3 groups selected from alkylsulfonyl group], or (2) an oxygen atom, 5 containing 1-3 hetero atoms selected from sulfur atom and a nitrogen atom 10-membered monocyclic or heteroaryl groups bicyclic heteroaryl group [wherein the a) halogen atom, b) a hydroxyl group, c) 1 to 3 substituents which may be alkyl groups with a halogen atom, d) a hydroxyalkyl A group, e) an acyloxyalkyl group, f) an alkoxy group optionally substituted with 1 to 3 halogen atoms, g) an alkoxycarbonylalkoxy group, h) an alkylthio group, i) substituted with 1 to 2 halogen atoms An optionally substituted alkylenedioxy group, j) an amino group optionally substituted with 1 to 2 alkyl groups, k) an amino group substituted with an acyl group, l) a cycloalkyl group, and m) an alkylsulfonyl. May be substituted with 1 to 3 groups selected from the group]
Q represents a single bond, an alkylene group or an alkenylene group. ]
Or a pharmacologically acceptable salt thereof as an active ingredient.
環Aはベンゼン環又は含窒素6員芳香族複素環[当該ベンゼン環又は含窒素6員芳香族複素環は、R 11 以外にも(a)ハロゲン原子、(b)アルキル基(該アルキル基はハロゲン原子、水酸基、アルコキシ基、アミノ基、モノアルキルアミノ基及びジアルキルアミノ基から選ばれる基で置換されていてもよい)、(c)水酸基、(d)アルコキシ基、(e)アミノ基(該アミノ基はアルキル基及びアシル基から選ばれる1〜2個の基で置換されていてもよい)、(f)シアノ基、(g)カルボキシル基、(h)アルコキシカルボニル基、(i)アルケニル基(該アルケニル基はアルコキシ基で置換されていてもよい)、(j)アルカノイル基、(k)シクロアルキル基および(l)カルバモイル基(該カルバモイル基は1〜2個のアルキル基で置換されていてもよい)から選ばれる同一もしくは異なる1〜3個の置換基を有していてもよい]、
R11は式:RaaSO2NH−、RaaSO2NH−CH2−又は(Rb)(Rc)NSO2−で示される基、
Raaはアルキル基、シクロアルキル基、1〜2個のアルキル基で置換されていてもよいアミノ基、フェニル基又は5〜6員単環式ヘテロアリール基、
Rb及びRcは同一又は異なって水素原子、アルキル基又はシクロアルキル基、
R21およびR31は、一方が水素原子、ハロゲン原子又はアルキル基、他方が水素原子、アルキル基、アルコキシカルボニル基、フェニル基又はハロゲノフェニル基であるか、或いは両者が互いに結合して隣接炭素原子と共に(a)シクロアルキル基、(b)シクロアルケニル基及び(c)飽和もしくは不飽和5〜8員含窒素、含酸素もしくは含硫単環式複素環式基から選ばれる飽和もしくは不飽和環式基を形成し、
Xaは酸素原子、硫黄原子、メチレン基又は式:−NH−で示される基、
Yaは式:−C(=O)−、−C(=S)−又は−CH(R51)−で示される基、
R51は水素原子又はフェニル基、
Ar1は(a)ハロゲン原子、水酸基、シアノ基、ニトロ基、1〜3個のハロゲン原子で置換されていてもよいアルキル基、ヒドロキシアルキル基、アシルオキシアルキル基、1〜3個のハロゲン原子で置換されていてもよいアルコキシ基、アルコキシカルボニルアルコキシ基、アルキルチオ基、1〜2個のハロゲン原子で置換されていてもよいアルキレンジオキシ基、1〜2個のアルキル基で置換されていてもよいアミノ基、アシル基で置換されたアミノ基、シクロアルキル基及びアルキルスルホニル基から選ばれる1〜3個の基で置換されていてもよいフェニル(又はナフチル)基;
(b)ハロゲン原子及びトリハロゲノアルキル基から選ばれる1〜2個の基で置換されていてもよいチエニル基(該チエニル基はベンゼン環と縮合していてもよい);
(c)ハロゲン原子、ニトロ基、アルキル基及びトリハロゲノアルキル基から選ばれる1〜2個の基で置換されていてもよいピリジル基;
(d)ハロゲン原子で置換されていてもよいピリミジニル基;
(e)キノリル基;
(f)ハロゲン原子で置換されていてもよいピリダジニル基;
(g)ピロリル基;又は
(h)フリル基(該フリル基はベンゼン環と縮合していてもよい)、
(i)チアゾリル基(該チアゾリル基はベンゼン環と縮合していてもよい)、又は
(j)イミダゾリル基(該イミダゾリル基はベンゼン環と縮合していてもよく、かつアルキル基で置換されていてもよい)、および
Qは単結合手、アルキレン基又はアルケニレン基
を表す。〕
で示される化合物又はその薬理的に許容し得る塩を有効成分としてなる医薬組成物。 Formula [Ia]:
Ring A is a benzene ring or a nitrogen-containing 6-membered aromatic heterocycle [the benzene ring or nitrogen-containing 6-membered aromatic heterocycle includes, in addition to R 11 , (a) a halogen atom, (b) an alkyl group (the alkyl group Optionally substituted with a group selected from a halogen atom, a hydroxyl group, an alkoxy group, an amino group, a monoalkylamino group and a dialkylamino group), (c) a hydroxyl group, (d) an alkoxy group, (e) an amino group The amino group may be substituted with one or two groups selected from an alkyl group and an acyl group), (f) a cyano group, (g) a carboxyl group, (h) an alkoxycarbonyl group, and (i) an alkenyl group. (The alkenyl group may be substituted with an alkoxy group), (j) an alkanoyl group, (k) a cycloalkyl group, and (l) a carbamoyl group (the carbamoyl group is one to two alkyl groups). In may have the same or different 1 to 3 substituents selected from the may be) Replace,
R 11 is a group represented by the formula: R aa SO 2 NH—, R aa SO 2 NH—CH 2 — or (R b ) (R c ) NSO 2 —,
R aa is an alkyl group, a cycloalkyl group, an amino group optionally substituted with 1 to 2 alkyl groups, a phenyl group, or a 5-6 membered monocyclic heteroaryl group,
R b and R c are the same or different and each represents a hydrogen atom, an alkyl group or a cycloalkyl group,
R 21 and R 31 are either a hydrogen atom, a halogen atom or an alkyl group, the other is a hydrogen atom, an alkyl group, an alkoxycarbonyl group, a phenyl group or a halogenophenyl group, or both are bonded to each other to form an adjacent carbon atom. And a saturated or unsaturated cyclic group selected from (a) a cycloalkyl group, (b) a cycloalkenyl group and (c) a saturated or unsaturated 5- to 8-membered nitrogen-containing, oxygen-containing or sulfur-containing monocyclic heterocyclic group Form a group,
Xa is an oxygen atom, a sulfur atom, a methylene group or a group represented by the formula: -NH-
Y a is a group represented by the formula: —C (═O) —, —C (═S) — or —CH (R 51 ) —,
R 51 represents a hydrogen atom or a phenyl group,
Ar 1 is (a) a halogen atom, a hydroxyl group, a cyano group, a nitro group, an alkyl group optionally substituted with 1 to 3 halogen atoms, a hydroxyalkyl group, an acyloxyalkyl group, or 1 to 3 halogen atoms. Optionally substituted alkoxy group, alkoxycarbonylalkoxy group, alkylthio group, alkylenedioxy group optionally substituted with 1 to 2 halogen atoms, optionally substituted with 1 to 2 alkyl groups A phenyl (or naphthyl) group optionally substituted with 1 to 3 groups selected from an amino group, an amino group substituted with an acyl group, a cycloalkyl group and an alkylsulfonyl group;
(B) a thienyl group which may be substituted with one or two groups selected from a halogen atom and a trihalogenoalkyl group (the thienyl group may be condensed with a benzene ring);
(C) a pyridyl group optionally substituted by 1 to 2 groups selected from a halogen atom, a nitro group, an alkyl group and a trihalogenoalkyl group;
(D) a pyrimidinyl group optionally substituted by a halogen atom;
(E) a quinolyl group;
(F) a pyridazinyl group optionally substituted by a halogen atom;
(G) a pyrrolyl group; or (h) a furyl group (the furyl group may be condensed with a benzene ring),
(I) a thiazolyl group (the thiazolyl group may be condensed with a benzene ring), or (j) an imidazolyl group (the imidazolyl group may be condensed with a benzene ring and substituted with an alkyl group). And Q represents a single bond, an alkylene group or an alkenylene group. ]
Or a pharmacologically acceptable salt thereof as an active ingredient.
R11がC1−4アルキルスルホニルアミノ基、C3−6シクロアルキルスルホニルアミノ基、C1−4アルキルアミノスルホニル基、C1−4アルキルスルホニルアミノメチル基、アミノスルホニルアミノ基、ジ(C1−4アルキル)アミノスルホニルアミノ基又はモノ(C1−4アルキル)アミノスルホニル基、
R21及びR31は一方が水素原子又はC1−4アルキル基であって、他方が水素原子、ハロゲン原子、C1−4アルキル基又はフェニル基を表すか、或いは両者が互いに結合してC3−8シクロアルキル基を形成し、
Xaが酸素原子、硫黄原子、メチレン基又は式:−NH−で示される基、
Ar1が(a)ハロゲン原子、水酸基、シアノ基、ニトロ基、C1−4アルキル基、1〜3個のハロゲン原子で置換されたC1−4アルキル基、ヒドロキシ−C1−4アルキル基、アシルオキシ−C1−4アルキル基、C1−4アルコキシ基、1〜3個のハロゲン原子で置換されたC1−4アルコキシ基、C3−8シクロアルキル基、C1−4アルキルチオ基、1〜2個のC1−4アルキル基で置換されていてもよいアミノ基、C2−5アルカノイルアミノ基、C1−4アルキレンジオキシ基及び1〜2個のハロゲン原子で置換されたC1−4アルキレンジオキシ基から選ばれる1〜3個の基で置換されていてもよいフェニル基;(b)ナフチル基;(c)ハロゲン原子及びトリハロゲノ−C1−4アルキル基から選ばれる1〜2個の基で置換されていてもよいチエニル(又はベンゾチエニル)基;(d)ハロゲン原子、ニトロ基、C1−4アルキル基及びトリハロゲノ−C1−4アルキル基から選ばれる1〜2個の基で置換されていてもよいピリジル基;又は(e)ベンゾフラニル基、
Qが単結合手又はC1−4アルキレン基、および
Yaが式:−C(=O)−、−C(=S)−又は―CH2−で示される基
である請求項3記載の医薬組成物。 Ring A is a halogen atom, a hydroxyl group, a C 1-4 alkyl group, a trihalogeno-C 1-4 alkyl group, a hydroxy-C 1-4 alkyl group, a C 1-4 alkoxy-C 1-4 alkyl group other than R 11 A benzene ring optionally substituted with a group selected from a C 1-4 alkoxy group, an amino group, a C 2-4 alkenyl group, a C 2-5 alkanoyl group and a C 3-8 cycloalkyl group,
R 11 represents a C 1-4 alkylsulfonylamino group, a C 3-6 cycloalkylsulfonylamino group, a C 1-4 alkylaminosulfonyl group, a C 1-4 alkylsulfonylaminomethyl group, an aminosulfonylamino group, di (C 1 -4 alkyl) aminosulfonylamino group or a mono (C 1-4 alkyl) aminosulfonyl group,
One of R 21 and R 31 is a hydrogen atom or a C 1-4 alkyl group, and the other represents a hydrogen atom, a halogen atom, a C 1-4 alkyl group or a phenyl group, or both are bonded to each other to form C Forming a 3-8 cycloalkyl group,
Xa is an oxygen atom, a sulfur atom, a methylene group or a group represented by the formula: -NH-,
Ar 1 is (a) a halogen atom, a hydroxyl group, a cyano group, a nitro group, a C 1-4 alkyl group, a C 1-4 alkyl group substituted with 1 to 3 halogen atoms, a hydroxy-C 1-4 alkyl group , acyloxy -C 1-4 alkyl group, C 1-4 alkoxy groups, 1-3 C 1-4 alkoxy group substituted with a halogen atom, C 3-8 cycloalkyl group, C 1-4 alkylthio group, 1-2 C 1-4 alkyl amino group which may be substituted with a group, C 2-5 alkanoylamino group, C 1-4 C substituted with an alkylenedioxy group, and one to two halogen atoms A phenyl group optionally substituted by 1 to 3 groups selected from 1-4 alkylenedioxy groups; (b) a naphthyl group; (c) a halogen atom and 1 selected from a trihalogeno-C 1-4 alkyl group; ~ 2 The thienyl which may be substituted with a group (or benzothienyl) group; (d) a halogen atom, a nitro group, 1-2 groups selected from C 1-4 alkyl group and a trihalogeno -C 1-4 alkyl group A pyridyl group optionally substituted by: or (e) a benzofuranyl group,
Q is a single bond or a C 1-4 alkylene group, and Y a has the formula: -C (= O) -, - C (= S) - or -CH 2 - in the claim 3, wherein a group represented Pharmaceutical composition.
N−[4−(4−フルオロフェニル)−3−オキソ−2−フェニル−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロフェニル)−3−オキソ−2−フェニル−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−(2,2−ジメチル−3−オキソ−4−フェニル−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル)メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3,4−ジフルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロ−3−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3−クロロ−4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−メトキシフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]エタンスルホンアミド;
N−[4−(5−フルオロピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−(4−ベンジル−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル)メタンスルホンアミド;
N−(4−ベンジル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル)メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−2−メチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
4−(4−フルオロフェニル)−N,2,2−トリメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−スルホンアミド;
N−[4−(5−クロロ−2−チエニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N’−[4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]−N,N−ジメチルスルファミド;
N−[4−(4−フルオロフェニル)−2,2−ジメチル−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−3−オキソ−4−(3−チエニル)−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−3−オキソ−3,4−ジヒドロスピロ[1,4−ベンゾオキサジン−2,1’−シクロブタン]−7−イル]メタンスルホンアミド;
N−[1−(4−フルオロフェニル)−3,3−ジメチル−2−オキソ−1,2,3,4−テトラヒドロキノキサリン−6−イル]メタンスルホンアミド;
N−[4−[4−フルオロ−3−トリフルオロメチル)フェニル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−4−(4−メチルフェニル)−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−3−オキソ−3,4−ジヒドロスピロ[1,4−ベンゾオキサジン−2,1’−シクロプロパン]−7−イル]メタンスルホンアミド;
N−[2,2−ジエチル−4−(4−フルオロフェニル)−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2−エチル−4−(4−フルオロフェニル)−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−3−オキソ−4−[(4−トリフルオロメチル)フェニル]−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]スルファミド;
N−[4−(2,4−ジフルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−2,2−ジメチル−3−チオキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロ−2−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロ−3−メトキシフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロ−3−メトキシフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
4−(4−フルオロ−3−メチルフェニル)−N,2,2−トリメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−スルホンアミド;
N−[4−[3−(ジメチルアミノ)−4−フルオロフェニル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3−クロロ−4−フルオロフェニル)−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(2−クロロ−4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロ−2−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロ−2−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−ブロモフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−2,2,6−トリメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[6−アミノ−4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−[3−(ジフルオロメチル)−4−フルオロフェニル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
4−(4−クロロフェニル)−N,2,2−トリメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−スルホンアミド;
N−[4−(4−クロロ−2−シアノフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
4−(4−ブロモフェニル)−N,2,2−トリメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−スルホンアミド;
N−[4−(5−クロロピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−クロロ−4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−ブロモ−2−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−[4−クロロ−3−(トリフルオロメチル)フェニル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−[3−フルオロ−4−(トリフルオロメチル)フェニル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロ−3−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロ−3−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3−フルオロ−4−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
4−(4−クロロ−2−メチルフェニル)−N,2,2−トリメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−スルホンアミド;
N−[4−(2,4−ジメチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3−クロロ−4−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3,4−ジフルオロ−5−メトキシフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3,4−ジクロロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−4−(2−ナフチル)−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロ−2,6−ジメチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−ブロモ−4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−クロロ−2−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−クロロ−4−(4−クロロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−2,2,5−トリメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−ブロモ−3−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(2,2−ジフルオロ−1,3−ベンゾジオキソール−5−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−(4−メシチル−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル)メタンスルホンアミド;
N−[4−(2,6−ジメチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロ−2,6−ジメチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−ブロモ−3−メチルピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−フルオロ−4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3,5−ジクロロピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロ−2,3−ジメチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3−クロロ−2−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−フルオロ−2−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−3−オキソ−4−(1−フェニルエチル)−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−4−(3−メチルベンジル)−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−{2,2−ジメチル−4−[2−メチル−5−(トリフルオロメチル)フェニル]−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル}メタンスルホンアミド;
N−[2,2−ジメチル−3−オキソ−4−(2,4,6−トリフルオロフェニル)−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
安息香酸2−クロロ−5−[2,2−ジメチル−7−[(メチルスルホニル)アミノ]−3−オキソ−2,3−ジヒドロ−4H−1,4−ベンゾオキサジン−4−イル]ベンジル;
N−[4−(4−クロロ−2−メトキシ−5−メチルフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(6−クロロ−2,2−ジフルオロ−1,3−ベンゾジオキソール−5−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−4−(3−メチル−5−ニトロピリジン−2−イル)−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−クロロ−3−メチルピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−[4−フルオロ−2−(トリフルオロメチル)フェニル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−4−[2−メチル−4−(トリフルオロメチル)フェニル]−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−5−ビニル−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロフェニル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−クロロピリジン−2−イル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−[3−クロロ−5−(トリフルオロメチル)ピリジン−2−イル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3−クロロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−[5−ブロモ−6−メチルピリジン−2−イル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−フルオロ−4−(5−フルオロピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−3−オキソ−4−[(5−(トリフルオロメチル)−2−チエニル]−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(6−クロロ−4−メチルピリジン−3−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−ブロモピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−[4−クロロ−3−(ヒドロキシメチル)フェニル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(6−ブロモ−5−メチルピリジン−3−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(6−クロロ−2−メチルピリジン−3−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−{2,2−ジメチル−3−オキソ−4−[5−(トリフルオロメチル)ピリジン−2−イル]−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル}メタンスルホンアミド;
N−{2,2−ジメチル−4−[3−メチル−6−(トリフルオロメチル)ピリジン−2−イル]−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル}メタンスルホンアミド
N−[4−(5−クロロ−3−フルオロピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3−クロロフェニル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−ブロモピリジン−2−イル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−クロロ−3−メチルピリジン−2−イル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−{5−フルオロ−2,2−ジメチル−3−オキソ−4−[5−(トリフルオロメチル)ピリジン−2−イル]−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル}メタンスルホンアミド;
N−[4−(5−フルオロ−3−メチルピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−クロロ−3−フルオロピリジン−2−イル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−[4−クロロ−3−(ヒドロキシメチル)フェニル]−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
安息香酸 2−クロロ−5−[5−フルオロ−2,2−ジメチル−7−[(メチルスルホニル)アミノ]−3−オキソ−2,3−ジヒドロ−4H−1,4−ベンゾオキサジン−4−イル]ベンジル;
N−[4−(2,6−ジメチルピリジン−3−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−シクロプロピル−4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−フルオロ−4−[3−フルオロ−4−(トリフルオロメチル)フェニル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−フルオロ−2,2−ジメチル−3−オキソ−4−[4−(トリフルオロメチル)フェニル]−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−フルオロ−4−[4−フルオロ−3−(トリフルオロメチル)フェニル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3−クロロ−4−フルオロフェニル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3,4−ジフルオロフェニル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−フルオロ−4−(5−フルオロ−6−メチルピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(6−クロロ−2−メチルピリジン−3−イル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロ−2−フルオロフェニル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−フルオロ−6−メチルピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(ベンゾチエン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(ベンゾフラン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−[2−クロロ−6−(トリフルオロメチル)ピリジン−3−イル]−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロフェニル)−5−(メトキシメチル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−4−[3−メチル−5−(トリフルオロメチル)ピリジン−2−イル]−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−4−[2−メチル−6−(トリフルオロメチル)ピリジン−3−イル]−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[2,2−ジメチル−4−[2−メチル−5−(トリフルオロメチル)ピリジン−3−イル]−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−エチル−4−(4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−フルオロ−2,2−ジメチル−3−オキソ−4−[5−(トリフルオロメチル)−2−チエニル]−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−フルオロ−4−(5−フルオロ−3−メチルピリジン−2−イル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(6−クロロ−2,2−ジフルオロ−1,3−ベンゾジオキソール−5−イル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(2,2−ジフルオロ−1,3−ベンゾジオキソール−5−イル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(5−ブロモ−3−メチルピリジン−2−イル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[5−フルオロ−2,2−ジメチル−4−[3−メチル−5−(トリフルオロメチル)ピリジン−2−イル]−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−クロロ−2−メチルフェニル)−5−フルオロ−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(3−アミノ−4−フルオロフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
N−[4−(4−フルオロ−2−メトキシフェニル)−2,2−ジメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル]メタンスルホンアミド;
4−(3−クロロ−4−フルオロフェニル)−N,2,2−トリメチル−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−スルホンアミド;
N−{2,2−ジメチル−3−オキソ−4−[3−(トリフルオロメチル)フェニル]−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル}メタンスルホンアミド;および
N−{2,2−ジメチル−4−[2−メチル−3−(トリフルオロメチル)フェニル]−3−オキソ−3,4−ジヒドロ−2H−1,4−ベンゾオキサジン−7−イル}メタンスルホンアミド;
からなる群より選ばれる化合物もしくはその薬理的に許容し得る塩を有効成分としてなる医薬組成物。 N- (3-oxo-2,4-diphenyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl) methanesulfonamide;
N- [4- (4-fluorophenyl) -3-oxo-2-phenyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-chlorophenyl) -3-oxo-2-phenyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- (2,2-dimethyl-3-oxo-4-phenyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl) methanesulfonamide;
N- [4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-chlorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (3,4-difluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Fluoro-3-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (3-chloro-4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-methoxyphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] ethanesulfonamide;
N- [4- (5-fluoropyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- (4-benzyl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl) methanesulfonamide;
N- (4-benzyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl) methanesulfonamide;
N- [4- (4-fluorophenyl) -2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
4- (4-fluorophenyl) -N, 2,2-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide;
N- [4- (5-chloro-2-thienyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N ′-[4- (4-Fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] -N, N-dimethylsulfami De;
N- [4- (4-fluorophenyl) -2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [2,2-dimethyl-3-oxo-4- (3-thienyl) -3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-fluorophenyl) -3-oxo-3,4-dihydrospiro [1,4-benzoxazine-2,1′-cyclobutane] -7-yl] methanesulfonamide;
N- [1- (4-fluorophenyl) -3,3-dimethyl-2-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl] methanesulfonamide;
N- [4- [4-Fluoro-3-trifluoromethyl) phenyl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfone An amide;
N- [2,2-dimethyl-4- (4-methylphenyl) -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-fluorophenyl) -3-oxo-3,4-dihydrospiro [1,4-benzoxazine-2,1′-cyclopropane] -7-yl] methanesulfonamide;
N- [2,2-diethyl-4- (4-fluorophenyl) -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [2-ethyl-4- (4-fluorophenyl) -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [2,2-dimethyl-3-oxo-4-[(4-trifluoromethyl) phenyl] -3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] sulfamide;
N- [4- (2,4-difluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-fluorophenyl) -2,2-dimethyl-3-thioxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Fluoro-2-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Chloro-3-methoxyphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Fluoro-3-methoxyphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
4- (4-Fluoro-3-methylphenyl) -N, 2,2-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide;
N- [4- [3- (Dimethylamino) -4-fluorophenyl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfone An amide;
N- [4- (3-chloro-4-fluorophenyl) -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (2-chloro-4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Chloro-2-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Chloro-2-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Bromophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-fluorophenyl) -2,2,6-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [6-amino-4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- [3- (Difluoromethyl) -4-fluorophenyl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfone An amide;
4- (4-chlorophenyl) -N, 2,2-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide;
N- [4- (4-Chloro-2-cyanophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
4- (4-bromophenyl) -N, 2,2-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide;
N- [4- (5-chloropyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [5-chloro-4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Bromo-2-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- [4-Chloro-3- (trifluoromethyl) phenyl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- [3-Fluoro-4- (trifluoromethyl) phenyl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (4-Chloro-3-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Chloro-3-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (3-Fluoro-4-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
4- (4-Chloro-2-methylphenyl) -N, 2,2-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide;
N- [4- (2,4-dimethylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (3-Chloro-4-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (3,4-Difluoro-5-methoxyphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide ;
N- [4- (3,4-dichlorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [2,2-dimethyl-4- (2-naphthyl) -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Fluoro-2,6-dimethylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide ;
N- [5-bromo-4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (5-chloro-2-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [5-chloro-4- (4-chlorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-fluorophenyl) -2,2,5-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Bromo-3-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (2,2-Difluoro-1,3-benzodioxol-5-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine -7-yl] methanesulfonamide;
N- (4-mesityl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl) methanesulfonamide;
N- [4- (2,6-dimethylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Chloro-2,6-dimethylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide ;
N- [4- (5-Bromo-3-methylpyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [5-fluoro-4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (3,5-dichloropyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide ;
N- [4- (4-Fluoro-2,3-dimethylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide ;
N- [4- (3-chloro-2-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (5-fluoro-2-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [2,2-dimethyl-3-oxo-4- (1-phenylethyl) -3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [2,2-dimethyl-4- (3-methylbenzyl) -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- {2,2-dimethyl-4- [2-methyl-5- (trifluoromethyl) phenyl] -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl} methane Sulfonamide;
N- [2,2-dimethyl-3-oxo-4- (2,4,6-trifluorophenyl) -3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
2-chloro-5- [2,2-dimethyl-7-[(methylsulfonyl) amino] -3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl] benzyl benzoate;
N- [4- (4-Chloro-2-methoxy-5-methylphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (6-Chloro-2,2-difluoro-1,3-benzodioxol-5-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1, 4-Benzoxazin-7-yl] methanesulfonamide;
N- [2,2-dimethyl-4- (3-methyl-5-nitropyridin-2-yl) -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (5-Chloro-3-methylpyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- [4-Fluoro-2- (trifluoromethyl) phenyl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [2,2-dimethyl-4- [2-methyl-4- (trifluoromethyl) phenyl] -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-5-vinyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-chlorophenyl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (5-chloropyridin-2-yl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- [3-Chloro-5- (trifluoromethyl) pyridin-2-yl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [4- (3-chlorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- [5-Bromo-6-methylpyridin-2-yl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [5-Fluoro-4- (5-fluoropyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [2,2-dimethyl-3-oxo-4-[(5- (trifluoromethyl) -2-thienyl] -3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (6-Chloro-4-methylpyridin-3-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (5-bromopyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- [4-Chloro-3- (hydroxymethyl) phenyl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfone An amide;
N- [4- (6-Bromo-5-methylpyridin-3-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (6-Chloro-2-methylpyridin-3-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- {2,2-dimethyl-3-oxo-4- [5- (trifluoromethyl) pyridin-2-yl] -3,4-dihydro-2H-1,4-benzoxazin-7-yl} methane Sulfonamide;
N- {2,2-dimethyl-4- [3-methyl-6- (trifluoromethyl) pyridin-2-yl] -3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl} methanesulfonamide N- [4- (5-chloro-3-fluoropyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine -7-yl] methanesulfonamide;
N- [4- (3-chlorophenyl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (5-Bromopyridin-2-yl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (5-Chloro-3-methylpyridin-2-yl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- {5-Fluoro-2,2-dimethyl-3-oxo-4- [5- (trifluoromethyl) pyridin-2-yl] -3,4-dihydro-2H-1,4-benzoxazine-7 -Yl} methanesulfonamide;
N- [4- (5-Fluoro-3-methylpyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (5-Chloro-3-fluoropyridin-2-yl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [4- [4-Chloro-3- (hydroxymethyl) phenyl] -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7- Yl] methanesulfonamide;
Benzoic acid 2-chloro-5- [5-fluoro-2,2-dimethyl-7-[(methylsulfonyl) amino] -3-oxo-2,3-dihydro-4H-1,4-benzoxazine-4- Yl] benzyl;
N- [4- (2,6-Dimethylpyridin-3-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide ;
N- [5-cyclopropyl-4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [5-Fluoro-4- [3-fluoro-4- (trifluoromethyl) phenyl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [5-Fluoro-2,2-dimethyl-3-oxo-4- [4- (trifluoromethyl) phenyl] -3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [5-Fluoro-4- [4-fluoro-3- (trifluoromethyl) phenyl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [4- (3-Chloro-4-fluorophenyl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (3,4-Difluorophenyl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide ;
N- [5-Fluoro-4- (5-fluoro-6-methylpyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [4- (6-Chloro-2-methylpyridin-3-yl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [4- (4-Chloro-2-fluorophenyl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (5-Fluoro-6-methylpyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (benzothien-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (benzofuran-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- [2-Chloro-6- (trifluoromethyl) pyridin-3-yl] -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [4- (4-Fluorophenyl) -5- (methoxymethyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfone An amide;
N- [2,2-dimethyl-4- [3-methyl-5- (trifluoromethyl) pyridin-2-yl] -3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [2,2-dimethyl-4- [2-methyl-6- (trifluoromethyl) pyridin-3-yl] -3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [2,2-dimethyl-4- [2-methyl-5- (trifluoromethyl) pyridin-3-yl] -3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [5-ethyl-4- (4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [5-Fluoro-2,2-dimethyl-3-oxo-4- [5- (trifluoromethyl) -2-thienyl] -3,4-dihydro-2H-1,4-benzoxazine-7- Yl] methanesulfonamide;
N- [5-Fluoro-4- (5-fluoro-3-methylpyridin-2-yl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [4- (6-Chloro-2,2-difluoro-1,3-benzodioxol-5-yl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro- 2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (2,2-difluoro-1,3-benzodioxol-5-yl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1, 4-Benzoxazin-7-yl] methanesulfonamide;
N- [4- (5-Bromo-3-methylpyridin-2-yl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7 -Yl] methanesulfonamide;
N- [5-Fluoro-2,2-dimethyl-4- [3-methyl-5- (trifluoromethyl) pyridin-2-yl] -3-oxo-3,4-dihydro-2H-1,4- Benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Chloro-2-methylphenyl) -5-fluoro-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methane Sulfonamide;
N- [4- (3-amino-4-fluorophenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
N- [4- (4-Fluoro-2-methoxyphenyl) -2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl] methanesulfonamide;
4- (3-chloro-4-fluorophenyl) -N, 2,2-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide;
N- {2,2-dimethyl-3-oxo-4- [3- (trifluoromethyl) phenyl] -3,4-dihydro-2H-1,4-benzoxazin-7-yl} methanesulfonamide; and N- {2,2-dimethyl-4- [2-methyl-3- (trifluoromethyl) phenyl] -3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl} methane Sulfonamide;
A pharmaceutical composition comprising as an active ingredient a compound selected from the group consisting of: or a pharmacologically acceptable salt thereof.
環A2はR00以外にハロゲン原子及びアルキルオキシ基から選ばれる1〜2個の基で置換されていてもよいベンゼン環、
R00はニトロ基又はアミノ基、R22及びR32は一方が水素原子又はアルキル基であり、他方がアルキル基、フェニル基又はハロゲノフェニル基を表し、
Xbは酸素原子又は硫黄原子、
Ybは式:−C(=O)−又は−CH(R52)−で示される基、
R52は水素原子又はフェニル基、
Ar2はハロゲン原子、シアノ基、アルキル基、トリハロゲノアルキル基及びアルキレンジオキシ基(1〜2個のハロゲン原子で置換されていてもよい)から選ばれる1〜3個の基で置換されていてもよいフェニル基またはハロゲン原子及びアルキル基から選ばれる1〜2個の基で置換されていてもよいピリジル基、および
Qは単結合手、アルキレン基又はアルケニレン基
を表す。〕
で示される化合物又はその薬理的に許容し得る塩を有効成分としてなる医薬組成物。 General formula [ii]:
Ring A 2 is a benzene ring which may be substituted with one or two groups selected from a halogen atom and an alkyloxy group in addition to R 00 ,
R 00 represents a nitro group or amino group, R 22 and R 32 each represents a hydrogen atom or an alkyl group, and the other represents an alkyl group, a phenyl group or a halogenophenyl group,
X b is an oxygen atom or a sulfur atom,
Y b is a group represented by the formula: —C (═O) — or —CH (R 52 ) —,
R 52 represents a hydrogen atom or a phenyl group,
Ar 2 is substituted with 1 to 3 groups selected from a halogen atom, a cyano group, an alkyl group, a trihalogenoalkyl group and an alkylenedioxy group (which may be substituted with 1 to 2 halogen atoms). An optionally substituted phenyl group or a pyridyl group optionally substituted with 1 to 2 groups selected from a halogen atom and an alkyl group; and Q represents a single bond, an alkylene group or an alkenylene group. ]
Or a pharmacologically acceptable salt thereof as an active ingredient.
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