JP2008539944A5 - - Google Patents

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JP2008539944A5
JP2008539944A5 JP2008511096A JP2008511096A JP2008539944A5 JP 2008539944 A5 JP2008539944 A5 JP 2008539944A5 JP 2008511096 A JP2008511096 A JP 2008511096A JP 2008511096 A JP2008511096 A JP 2008511096A JP 2008539944 A5 JP2008539944 A5 JP 2008539944A5
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signal
waveform signal
waveform
subject
captured
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Priority claimed from PCT/US2005/016968 external-priority patent/WO2006124023A1/en
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Claims (31)

呼吸を制御するための第1の波形信号を生成する方法であって、
被療者の身体内で生成され、捕捉された呼吸の制御に有効な複数の波形信号から信号成分を抽出する段階と、
前記捕捉された波形信号と前記抽出された信号成分を記憶媒体に記憶する段階と、
前記被療者の身体に伝達するための第1の波形信号を前記捕捉された波形信号に基づいて生成する段階と、
を含み、
前記第1の波形信号は、前記捕捉された波形信号の少なくとも1つに対応し且つ呼吸の制御に有効な第2の波形信号を含む方法。
A method for generating a first waveform signal for controlling respiration, comprising:
Extracting signal components from a plurality of waveform signals that are generated and captured within the body of the subject and are effective in controlling the captured breath;
Storing the captured waveform signal and the extracted signal component in a storage medium;
Generating a first waveform signal for transmission to the body of the patient based on the captured waveform signal;
Including
The method wherein the first waveform signal includes a second waveform signal that corresponds to at least one of the captured waveform signals and is effective in controlling respiration.
前記第1の波形信号は前記被療者の神経系に伝達されるものである、請求項1に記載の方法。  The method according to claim 1, wherein the first waveform signal is transmitted to the nervous system of the subject. 呼吸を制御するための波形信号を生成する方法であって、
第1の被療者の身体内で生成され、捕捉された第1の複数の波形信号であって、該第1の複数の波形信号に含まれる、呼吸の制御に有効な第1の波形信号から基準呼吸波形信号を生成する段階と、
前記第1の被療者の身体内で生成され、捕捉した第2の複数の波形信号であって、該第2の複数の波形信号に含まれる、呼吸の制御に有効な少なくとも第2の波形信号と、前記基準呼吸波形信号を比較する段階と、
呼吸の制御に有効な、被療者の身体に伝達するための第3の波形信号を、前記基準呼吸信号と第2の波形信号の前記比較に基づいて生成する段階と、
を含む方法。
A method of generating a waveform signal for controlling respiration,
A first plurality of waveform signals generated and captured in the body of the first patient, the first waveform signals being included in the first plurality of waveform signals and effective for breathing control Generating a reference respiratory waveform signal from:
A plurality of second waveform signals generated and captured in the body of the first patient, and at least a second waveform effective for breathing control, which is included in the second plurality of waveform signals Comparing a signal with the reference respiratory waveform signal;
Generating a third waveform signal to be transmitted to the body of the subject effective for controlling respiration based on the comparison of the reference respiratory signal and the second waveform signal;
Including methods.
前記捕捉された波形信号は、複数の被療者から捕捉された前記第1の複数の波形信号からなる、請求項3に記載の方法。  4. The method of claim 3, wherein the captured waveform signal comprises the first plurality of waveform signals captured from a plurality of subjects. 前記第3の波形信号は前記第2の波形信号に対応する、請求項3に記載の方法。  The method of claim 3, wherein the third waveform signal corresponds to the second waveform signal. 前記第3の波形信号は前記基準呼吸波形信号に対応する、請求項3に記載の方法。  The method of claim 3, wherein the third waveform signal corresponds to the reference respiratory waveform signal. 前記第3の波形信号は前記被療者の神経系に伝達される、請求項3に記載の方法。  4. The method of claim 3, wherein the third waveform signal is transmitted to the subject's nervous system. 前記被療者は人間を含む、請求項3に記載の方法。  The method of claim 3, wherein the subject includes a human. 前記被療者は動物を含む、請求項3に記載の方法。  The method of claim 3, wherein the subject comprises an animal. 呼吸を制御するための第3の波形信号を生成する方法であって、
第1の被療者の身体内で生成され、捕捉された第1の複数の波形信号であって、該第1の複数の波形信号に含まれる、呼吸の制御に有効な第1の波形信号を記憶媒体内の第1の場所に記憶する段階と、
前記第1の波形信号から基準呼吸波形信号を生成する段階と、
前記第1の被療者の身体に生成され、捕捉された第2の複数の波形信号であって、該第2の複数の波形信号に含まれる、呼吸の制御に有効な少なくとも第2の波形信号を前記記憶媒体内の第2の場所に記憶する段階と、
前記基準呼吸波形信号を前記第2の波形信号と比較する段階と、
呼吸の制御に有効な、被療者の身体に伝達するための第3の波形信号を、前記基準呼吸信号と第2の波形信号の前記比較に基づいて、生成する段階と、
を含む方法。
A method for generating a third waveform signal for controlling respiration, comprising:
A first plurality of waveform signals generated and captured within the body of the first patient, the first waveform signals being included in the first plurality of waveform signals and effective for breathing control Storing at a first location in the storage medium;
Generating a reference respiratory waveform signal from the first waveform signal;
A plurality of second waveform signals generated and captured in the body of the first patient, and included in the second plurality of waveform signals, and at least a second waveform effective for breathing control Storing a signal in a second location in the storage medium;
Comparing the reference respiratory waveform signal with the second waveform signal;
Generating a third waveform signal to be transmitted to the body of the subject effective for controlling respiration based on the comparison of the reference respiratory signal and the second waveform signal;
Including methods.
前記捕捉した波形信号は、複数の被療者から捕捉した前記第1の複数の波形信号からなる、請求項10に記載の方法。  The method of claim 10, wherein the captured waveform signal comprises the first plurality of waveform signals captured from a plurality of subjects. 前記第3の波形信号は前記被療者の神経系に伝達されるものである、請求項10に記載の方法。  The method according to claim 10, wherein the third waveform signal is transmitted to the nervous system of the subject. 前記被療者は人間を含む、請求項10に記載の方法。  The method of claim 10, wherein the subject includes a human. 前記被療者は動物を含む、請求項10に記載の方法。  The method of claim 10, wherein the subject comprises an animal. 呼吸を制御するための第2の波形信号を生成する方法であって、
被療者の呼吸状態を監視することにより提供された、少なくとも一つが被療者の呼吸器系の状態を示す呼吸器系状態信号と、被療者の身体内で生成され、捕捉された呼吸の制御に有効な第1の複数の波形信号であって、該第1の複数の波形信号に含まれる、呼吸の制御に有効な第1の波形信号とを記憶媒体内の第1の場所に記憶する段階と、
前記呼吸器系状態信号に応じて前記被療者に伝達される呼吸の制御に有効な前記第2の波形信号を、前記第1の波形信号に基づいて生成する段階と、
を含む方法。
A method of generating a second waveform signal for controlling respiration, comprising:
Provided by monitoring the respiratory status of the subject, at least one respiratory status signal indicating the status of the subject's respiratory system, and breath generated and captured within the subject's body A first plurality of waveform signals effective for control of the first waveform signal, which are included in the first plurality of waveform signals and are effective for controlling respiration, in a first location in the storage medium Remembering, and
Generating the second waveform signal effective for controlling respiration transmitted to the subject in response to the respiratory system state signal based on the first waveform signal;
Including methods.
前記第2の波形信号は前記被療者の神経系に伝達されるものである、請求項15に記載の方法。  The method according to claim 15, wherein the second waveform signal is transmitted to the nervous system of the subject. 前記第2の波形信号は前記被療者の標的ゾーンに伝達されるものであり、前記標的ゾーンは首部、頭部および胸部から選択される、請求項15に記載の方法。  The method according to claim 15, wherein the second waveform signal is transmitted to a target zone of the subject, and the target zone is selected from a neck, a head, and a chest. 前記被療者は人間を含む、請求項15に記載の方法。  The method of claim 15, wherein the subject includes a human. 前記被療者は動物を含む、請求項15に記載の方法。  The method of claim 15, wherein the subject comprises an animal. 呼吸を制御するための第2の波形信号を生成する方法であって、
被療者の身体内で生成され、捕捉された第1の複数の波形信号であって、該第1の複数の波形信号に含まれる第1の波形信号から波形信号成分を抽出する段階と、
被療者の呼吸状態を監視することにより提供された、少なくとも1つが被療者の呼吸器系の状態を示す呼吸器系状態信号と、前記第1の波形信号と、前記波形信号成分とを記憶媒体に記憶する段階と、
前記呼吸器系状態信号に応じて前記被療者に伝達されるべき、呼吸の制御に有効な第2の波形信号を前記第1の波形信号に基づいて生成する段階と、
を含む方法。
A method of generating a second waveform signal for controlling respiration, comprising:
Extracting a waveform signal component from a first waveform signal included in the first plurality of waveform signals generated and captured within the body of the patient;
Provided by monitoring the respiratory state of the subject, at least one respiratory system state signal indicating the state of the respiratory system of the subject, the first waveform signal, and the waveform signal component Storing in a storage medium;
Generating, based on the first waveform signal, a second waveform signal effective for breathing control to be transmitted to the subject in response to the respiratory system state signal;
Including methods.
前記第2の波形信号は、前記波形信号成分の少なくとも1つに応じて前記被療者に伝達されるものである、請求項20に記載の方法  The method according to claim 20, wherein the second waveform signal is transmitted to the subject in accordance with at least one of the waveform signal components. 前記第2の波形信号は前記被療者の神経系に伝達されるものである、請求項20に記載の方法。  21. The method of claim 20, wherein the second waveform signal is transmitted to the subject's nervous system. 前記第2の波形信号は前記被療者の標的ゾーンに伝達されものであり、前記標的ゾーンは、首部、頭部および胸部から選択される、請求項20に記載の方法。  The method according to claim 20, wherein the second waveform signal is transmitted to a target zone of the subject, and the target zone is selected from a neck, a head, and a chest. 前記被療者は人間を含む、請求項20に記載の方法。  21. The method of claim 20, wherein the subject includes a human. 前記被療者は動物を含む、請求項20に記載の方法。  21. The method of claim 20, wherein the subject includes an animal. 呼吸を制御するシステムであって、
被療者の身体から、前記身体内で自然に生成され且つ呼吸の制御に有効な波形信号を表す波形信号を捕捉するための少なくとも第1の信号プローブと、
前記信号プローブと通信可能であり且つ前記波形信号を受け取り、更に前記捕捉した波形信号に基づいて、呼吸器系が調節信号として認識可能な少なくとも第1の波形信号を生成するプロセッサと、
前記被療者の身体と通信可能であり、前記第1の波形信号を前記被療者の身体に伝達して呼吸を調整し制御するための少なくとも第2の信号プローブと、
を有するシステム。
A system for controlling breathing,
At least a first signal probe for capturing from the body of the subject a waveform signal representing a waveform signal that is naturally generated in the body and is effective in controlling respiration;
A processor that is communicable with the signal probe and that receives the waveform signal and further generates at least a first waveform signal that is recognizable as a regulatory signal by the respiratory system based on the captured waveform signal;
At least a second signal probe that is communicable with the body of the patient and transmits and transmits the first waveform signal to the body of the patient to regulate and control respiration;
Having a system.
前記プロセッサは、前記捕捉した波形信号を記憶する記憶媒体を有する、請求項26に記載のシステム。  27. The system of claim 26, wherein the processor comprises a storage medium that stores the captured waveform signal. 前記第2の信号プローブは、被療者の神経系への直接伝達により、前記第1の波形信号を前記被療者に直接伝達するものである、請求項26に記載のシステム。  27. The system according to claim 26, wherein the second signal probe directly transmits the first waveform signal to the patient by direct transmission to the nervous system of the patient. 呼吸を制御するシステムであって、
被療者の呼吸器系の状態を監視し且つ被療者の呼吸器系の状態を示す少なくとも第1の呼吸器系状態信号を伝達する呼吸器系センサと、
被療者の身体から、前記身体内で自然に生成され呼吸の制御に有効な波形信号を表す波形信号を捕捉する少なくとも第1の信号プローブと、
前記信号プローブと通信可能であり且つ前記呼吸器系状態信号と前記波形信号を受け取り、更に前記捕捉した波形信号に基づいて、呼吸器系が調節信号として認識可能な少なくとも第1の波形信号を生成するプロセッサと、
前記被療者と通信可能であり、前記第1の波形信号を前記被療者に伝達して呼吸を制御するための少なくとも第2の信号プローブと、
を有するシステム。
A system for controlling breathing,
A respiratory system sensor for monitoring a respiratory system condition of the subject and transmitting at least a first respiratory system state signal indicative of the respiratory system state of the patient;
At least a first signal probe that captures from the body of the patient a waveform signal that is generated naturally within the body and represents a waveform signal that is effective in controlling respiration;
Generate at least a first waveform signal that is communicable with the signal probe and that receives the respiratory system state signal and the waveform signal and that can be recognized as a regulation signal by the respiratory system based on the captured waveform signal A processor to
At least a second signal probe capable of communicating with the patient and transmitting the first waveform signal to the patient to control respiration;
Having a system.
前記プロセッサは、前記捕捉した波形信号を記憶する記憶媒体を有する、請求項29に記載のシステム。  30. The system of claim 29, wherein the processor comprises a storage medium that stores the captured waveform signal. 前記第2の信号プローブは、被療者の神経系に直接伝達することによって前記第1の波形信号を前記被療者に直接伝達する、請求項29に記載のシステム。  30. The system of claim 29, wherein the second signal probe directly transmits the first waveform signal to the patient by directly transmitting to the patient's nervous system.
JP2008511096A 2005-05-13 2005-05-13 Method and system for controlling respiration with a neuroelectrically encoded signal Withdrawn JP2008539944A (en)

Applications Claiming Priority (1)

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PCT/US2005/016968 WO2006124023A1 (en) 2005-05-13 2005-05-13 Method and system to control respiration by means of neuro-electrical coded signals

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JP2008539944A5 true JP2008539944A5 (en) 2009-01-08

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EP (1) EP1879643A1 (en)
JP (1) JP2008539944A (en)
AU (1) AU2005331926A1 (en)
CA (1) CA2608303A1 (en)
MX (1) MX2007013980A (en)
WO (1) WO2006124023A1 (en)

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US9050005B2 (en) 2005-08-25 2015-06-09 Synapse Biomedical, Inc. Method and apparatus for transgastric neurostimulation
US8676323B2 (en) 2006-03-09 2014-03-18 Synapse Biomedical, Inc. Ventilatory assist system and methods to improve respiratory function
WO2008098001A2 (en) 2007-02-05 2008-08-14 Synapse Biomedical, Inc. Removable intramuscular electrode
US9820671B2 (en) 2007-05-17 2017-11-21 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
WO2009059033A1 (en) 2007-10-30 2009-05-07 Synapse Biomedical, Inc. Method of improving sleep disordered breathing
US8428726B2 (en) 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
US11471683B2 (en) 2019-01-29 2022-10-18 Synapse Biomedical, Inc. Systems and methods for treating sleep apnea using neuromodulation

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US6633779B1 (en) * 2000-11-27 2003-10-14 Science Medicus, Inc. Treatment of asthma and respiratory disease by means of electrical neuro-receptive waveforms
US6681136B2 (en) * 2000-12-04 2004-01-20 Science Medicus, Inc. Device and method to modulate blood pressure by electrical waveforms
US6775573B2 (en) * 2001-03-01 2004-08-10 Science Medicus Inc. Electrical method to control autonomic nerve stimulation of gastrointestinal tract

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