JP2008527034A5 - - Google Patents

Info

Publication number

JP2008527034A5

JP2008527034A5 JP2007552095A JP2007552095A JP2008527034A5 JP 2008527034 A5 JP2008527034 A5 JP 2008527034A5 JP 2007552095 A JP2007552095 A JP 2007552095A JP 2007552095 A JP2007552095 A JP 2007552095A JP 2008527034 A5 JP2008527034 A5 JP 2008527034A5

Authority

JP

Japan

Prior art keywords

angiotensin

pharmaceutical composition

composition according

derivative

subject

Prior art date

2006-01-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• QSBGWDDCOJYQGY-KOQODJNWSA-N Angiotensin IV Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)C(C)C)C1=CC=C(O)C=C1 QSBGWDDCOJYQGY-KOQODJNWSA-N 0.000 claims 12
• 239000003814 drug Substances 0.000 claims 12
• 102400000349 Angiotensin-4 Human genes 0.000 claims 10
• 101800000737 Angiotensin-4 Proteins 0.000 claims 10
• 230000008692 neointimal formation Effects 0.000 claims 10
• 230000002265 prevention Effects 0.000 claims 7
• 206010007572 Cardiac hypertrophy Diseases 0.000 claims 6
• 208000006029 Cardiomegaly Diseases 0.000 claims 6
• ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 claims 6
• 239000000126 substance Substances 0.000 claims 6
• 239000002671 adjuvant Substances 0.000 claims 3
• 239000003085 diluting agent Substances 0.000 claims 3
• 239000003937 drug carrier Substances 0.000 claims 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims 3
• 208000037803 restenosis Diseases 0.000 claims 3
• 239000005541 ACE inhibitor Substances 0.000 claims 2
• 101800000734 Angiotensin-1 Proteins 0.000 claims 2
• 102400000344 Angiotensin-1 Human genes 0.000 claims 2
• 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 claims 2
• 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 claims 2
• 229940127282 angiotensin receptor antagonist Drugs 0.000 claims 2
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 239000007787 solid Substances 0.000 claims 2
• 210000000130 stem cell Anatomy 0.000 claims 2
• PVHLMTREZMEJCG-GDTLVBQBSA-N Ile(5)-angiotensin II (1-7) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 PVHLMTREZMEJCG-GDTLVBQBSA-N 0.000 claims 1
• 208000034827 Neointima Diseases 0.000 claims 1
• LJXGOQOPNPFXFT-JWRYNVNRSA-N angiotensin (1-9) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 LJXGOQOPNPFXFT-JWRYNVNRSA-N 0.000 claims 1
• 108010021281 angiotensin I (1-7) Proteins 0.000 claims 1
• 239000002416 angiotensin derivative Substances 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000012907 medicinal substance Substances 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1