JP2008519842A - 抗感染剤としての８ａ，９−ジヒドロ−４ａ−ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 - Google Patents

抗感染剤としての８ａ，９−ジヒドロ−４ａ−ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 Download PDF

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JP2008519842A
JP2008519842A JP2007541310A JP2007541310A JP2008519842A JP 2008519842 A JP2008519842 A JP 2008519842A JP 2007541310 A JP2007541310 A JP 2007541310A JP 2007541310 A JP2007541310 A JP 2007541310A JP 2008519842 A JP2008519842 A JP 2008519842A
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Japan
Prior art keywords
alkyl
compound
alkoxy
amino
hydrogen
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Japanese (ja)
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JP2008519842A5 (https=
Inventor
バートン ジェイムズ ブラッドベリー，
ミリンド デシュパンド，
マイケル ジョン プッチ，
チウピン ワン，
ジェイソン アラン ワイルズ，
ヨンシェン ソン，
彰宏 橋本
エドレイン ルシアン，
Original Assignee
アキリオン ファーマシューティカルズ，インコーポレーテッド
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Publication of JP2008519842A publication Critical patent/JP2008519842A/ja
Publication of JP2008519842A5 publication Critical patent/JP2008519842A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007541310A 2004-11-11 2005-11-10 抗感染剤としての８ａ，９−ジヒドロ−４ａ−ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 Withdrawn JP2008519842A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62696104P 2004-11-11 2004-11-11
PCT/US2005/040725 WO2006118605A2 (en) 2004-11-11 2005-11-10 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents

Publications (2)

Publication Number Publication Date
JP2008519842A true JP2008519842A (ja) 2008-06-12
JP2008519842A5 JP2008519842A5 (https=) 2008-12-18

Family

ID=36980341

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007541310A Withdrawn JP2008519842A (ja) 2004-11-11 2005-11-10 抗感染剤としての８ａ，９−ジヒドロ−４ａ−ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物

Country Status (12)

Country Link
US (1) US20060100215A1 (https=)
EP (1) EP1809639B1 (https=)
JP (1) JP2008519842A (https=)
KR (1) KR20070085791A (https=)
CN (1) CN101120004A (https=)
AT (1) ATE445623T1 (https=)
AU (1) AU2005331275A1 (https=)
CA (1) CA2587485A1 (https=)
DE (1) DE602005017178D1 (https=)
IL (1) IL183153A0 (https=)
MX (1) MX2007005731A (https=)
WO (1) WO2006118605A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006272571B2 (en) 2005-07-27 2012-03-08 Achillion Pharmaceuticals, Inc. 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
WO2008021491A2 (en) 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
FR2645862B1 (fr) * 1989-04-18 1991-07-12 Esteve Labor Dr Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments
US5071848A (en) * 1989-10-23 1991-12-10 Abbott Laboratories Tricyclic quinoline antineoplastic agents
US5580872A (en) * 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
EP0541086A1 (en) * 1991-11-08 1993-05-12 Kaken Pharmaceutical Co., Ltd. Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
ATE304539T1 (de) * 2000-12-14 2005-09-15 Procter & Gamble Antimikrobielle chinolone
KR20060069836A (ko) * 2003-08-12 2006-06-22 아칠리온 파르마세우티칼스 인코포레이티드 항-감염제로서의 이소티아졸로퀴놀론 및 관련 화합물

Also Published As

Publication number Publication date
CN101120004A (zh) 2008-02-06
US20060100215A1 (en) 2006-05-11
ATE445623T1 (de) 2009-10-15
DE602005017178D1 (de) 2009-11-26
IL183153A0 (en) 2007-09-20
EP1809639A2 (en) 2007-07-25
CA2587485A1 (en) 2006-11-09
AU2005331275A1 (en) 2006-11-09
MX2007005731A (es) 2007-07-19
WO2006118605A2 (en) 2006-11-09
WO2006118605A3 (en) 2006-12-21
EP1809639B1 (en) 2009-10-14
KR20070085791A (ko) 2007-08-27

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JP2008519842A (ja) 抗感染剤としての８ａ，９−ジヒドロ−４ａ−ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物
JP2008519842A5 (https=)

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