JP2008518024A

JP2008518024A - ミコフェノール酸のホスホネート誘導体

ミコフェノール酸のホスホネート誘導体 Download PDF

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Publication number: JP2008518024A
Authority: JP; Japan
Prior art keywords: compound; formula; alkyl; independently; compound according
Prior art date: 2004-10-26
Legal status : Withdrawn

Application number

JP2007539091A

Other languages

English (en)

Japanese (ja)

Other versions

JP2008518024A5 (enExample

Inventor

ウィリアムジェイ．ワトキンス，

イソップチョー，

Original Assignee

ギリアードサイエンシーズ，インコーポレイテッド

Priority date

2004-10-26

Filing date

2005-10-26

Publication date

2008-05-29

2005-10-26 Application filed by ギリアードサイエンシーズ，インコーポレイテッド filed Critical ギリアードサイエンシーズ，インコーポレイテッド

2008-05-29 Publication of JP2008518024A publication Critical patent/JP2008518024A/ja

2008-10-16 Publication of JP2008518024A5 publication Critical patent/JP2008518024A5/ja

Status Withdrawn legal-status Critical Current

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HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title abstract description 10
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title description 50
229960000951 mycophenolic acid Drugs 0.000 title description 9
-1 mycophenolate oxime Chemical class 0.000 claims abstract description 413
239000000203 mixture Substances 0.000 claims abstract description 126
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230000004054 inflammatory process Effects 0.000 claims abstract description 31
206010028980 Neoplasm Diseases 0.000 claims abstract description 28
210000000056 organ Anatomy 0.000 claims abstract description 28
241000700605 Viruses Species 0.000 claims abstract description 19
208000036142 Viral infection Diseases 0.000 claims abstract description 18
230000009385 viral infection Effects 0.000 claims abstract description 18
206010052779 Transplant rejections Diseases 0.000 claims abstract description 17
201000011510 cancer Diseases 0.000 claims abstract description 16
230000004614 tumor growth Effects 0.000 claims abstract description 9
150000001875 compounds Chemical class 0.000 claims description 484
238000000034 method Methods 0.000 claims description 210
125000000217 alkyl group Chemical group 0.000 claims description 146
229910052760 oxygen Inorganic materials 0.000 claims description 124
UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 96
229910052757 nitrogen Inorganic materials 0.000 claims description 94
125000004432 carbon atom Chemical group C* 0.000 claims description 80
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 65
229910052739 hydrogen Inorganic materials 0.000 claims description 61
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 54
239000001257 hydrogen Substances 0.000 claims description 53
239000004480 active ingredient Substances 0.000 claims description 52
229910052717 sulfur Inorganic materials 0.000 claims description 52
238000009472 formulation Methods 0.000 claims description 51
125000006239 protecting group Chemical group 0.000 claims description 50
125000003118 aryl group Chemical group 0.000 claims description 49
239000003814 drug Substances 0.000 claims description 47
238000002360 preparation method Methods 0.000 claims description 47
125000000623 heterocyclic group Chemical group 0.000 claims description 37
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 33
125000005843 halogen group Chemical group 0.000 claims description 31
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 29
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