JP2008298598A5 - - Google Patents

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Publication number
JP2008298598A5
JP2008298598A5 JP2007145289A JP2007145289A JP2008298598A5 JP 2008298598 A5 JP2008298598 A5 JP 2008298598A5 JP 2007145289 A JP2007145289 A JP 2007145289A JP 2007145289 A JP2007145289 A JP 2007145289A JP 2008298598 A5 JP2008298598 A5 JP 2008298598A5
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Japan
Prior art keywords
liquid
polymer
microfluidic device
space
swollen
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JP2007145289A
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Japanese (ja)
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JP2008298598A (en
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Priority to JP2007145289A priority Critical patent/JP2008298598A/en
Priority claimed from JP2007145289A external-priority patent/JP2008298598A/en
Publication of JP2008298598A publication Critical patent/JP2008298598A/en
Publication of JP2008298598A5 publication Critical patent/JP2008298598A5/ja
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Claims (11)

液体を導入するための導入口と排出するための排出口を有する空間と該空間内に固定されたポリマーとを有する微小流体素子であって、前記ポリマーは液体中の成分によって膨潤し、且つ飽和状態まで膨潤した際に液体の流れ方向に交差する空間の断面を閉塞させないことを特徴とする微小流体素子。 A microfluidic device having a space having an inlet for introducing a liquid and a discharge port for discharging, and a polymer fixed in the space, the polymer being swollen by a component in the liquid and saturated A microfluidic device that does not block a cross section of a space that intersects a liquid flow direction when swollen to a state. 前記液体が生体分子含有水溶液であり、前記成分が水分であり、前記ポリマーが吸水性ポリマーであることを特徴とする請求項１に記載の微小流体素子。   The microfluidic device according to claim 1, wherein the liquid is a biomolecule-containing aqueous solution, the component is moisture, and the polymer is a water-absorbing polymer. 請求項１または２に記載の微小流体素子において、前記ポリマーが前記空間内でパターン化して配置されていることを特徴とする微小流体素子。 3. The microfluidic device according to claim 1 or 2, wherein the polymer is arranged in a pattern in the space. 前記空間が液体で充填され、前記ポリマーが飽和状態まで膨潤していることを特徴とする請求項１乃至３のいずれかに記載の微小流体素子。   The microfluidic device according to any one of claims 1 to 3, wherein the space is filled with a liquid, and the polymer is swollen to a saturated state. 請求項１乃至３のいずれかに記載の微小流体素子において、前記ポリマーが分子サイズに応じて分子を分離する機能を保有していることを特徴とする微小流体素子。 In the microfluidic device according to any one of claims 1 to 3, the microfluidic device, wherein the polymer holds a function of separating molecules according to molecular size. 請求項１乃至５のいずれかに記載の微小流体素子と、該微小流体素子が有する前記空間内に固定されたプローブ分子とを有することを特徴とする分子相互作用反応素子。 A molecular interaction reaction element comprising the microfluidic device according to claim 1 and probe molecules fixed in the space of the microfluidic device. 前記空間の導入口より液体を導入する工程と、
前記液体により膨潤するポリマーが微小構造体を形成する工程と、
前記ポリマーの膨潤により前記液体中の成分を分子サイズに応じて分離する工程と、
を少なくとも含むことを特徴とする、請求項５に記載の濃縮素子を用いた液体の濃縮方法。 Introducing a liquid from an inlet of the space;
The polymer swollen by the liquid forming a microstructure;
And separating according to component a molecular size of the liquid by swelling of the polymer,
The liquid concentration method using the concentration element according to claim 5, wherein 前記空間の導入口より液体を導入する工程と、
前記液体により膨潤するポリマーが微小構造体を形成する工程と、
該微小構造体領域において導入する前記液体の成分とプローブ分子との相互作用反応をおこなう工程と、を少なくとも含むことを特徴とする、請求項６に記載の分子相互作用反応素子を用いた分子相互作用反応方法。 Introducing liquid from the introduction port of the space;
The polymer swollen by the liquid forming a microstructure;
The molecular interaction using the molecular interaction reaction element according to claim 6, comprising at least an interaction reaction between the liquid component introduced into the microstructure region and a probe molecule. Action reaction method. 前記液体の成分と前記プローブ分子との相互作用反応を検出する工程を更に有することを特徴とする、請求項８に記載の分子相互作用反応方法。 9. The molecular interaction reaction method according to claim 8, further comprising a step of detecting an interaction reaction between the liquid component and the probe molecule. 前記空間の導入口より液体を導入する工程と、
前記液体により膨潤するポリマーが微小構造体を形成する工程と、
該微小構造体により液体が攪拌される工程と、
を少なくとも含む、請求項１乃至６のいずれかに記載の素子を用いた液体攪拌方法。 Introducing liquid from the introduction port of the space;
The polymer swollen by the liquid forming a microstructure;
A step of stirring the liquid by the microstructure,
The liquid stirring method using the element in any one of Claims 1 thru | or 6 containing at least. 請求項１乃至６のいずれかに記載の微小流体素子の製造方法において、
前記ポリマーを膨潤させた状態で前記空間内に固定する工程と、
前記ポリマーを乾燥させる工程と、
を少なくとも含むことを特徴とする微小流体素子の製造方法。 In the manufacturing method of the microfluidic device according to any one of claims 1 to 6,
Fixing the polymer in a swollen state in the space;
Drying the polymer;
A method for producing a microfluidic device, comprising:
JP2007145289A 2007-05-31 2007-05-31 Micro fluid element, its usage, and its manufacturing method Pending JP2008298598A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007145289A JP2008298598A (en) 2007-05-31 2007-05-31 Micro fluid element, its usage, and its manufacturing method

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Application Number Priority Date Filing Date Title
JP2007145289A JP2008298598A (en) 2007-05-31 2007-05-31 Micro fluid element, its usage, and its manufacturing method

Publications (2)

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JP2008298598A JP2008298598A (en) 2008-12-11
JP2008298598A5 true JP2008298598A5 (en) 2010-07-15

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JP2011163993A (en) * 2010-02-12 2011-08-25 Hitachi Ltd Sample analysis chip and sample analysis system
JP5268989B2 (en) 2010-05-11 2013-08-21 株式会社日立ハイテクノロジーズ Nucleic acid analysis reaction cell and nucleic acid analyzer
KR20120006591A (en) 2010-07-13 2012-01-19 삼성전자주식회사 Sensor for fluid preventing generation of air bubble
US20230311115A1 (en) * 2020-08-31 2023-10-05 Fujimori Kogyo Co., Ltd. Method for manufacturing microchip for liquid sample analysis

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JPS63151845A (en) * 1986-12-16 1988-06-24 Fuji Photo Film Co Ltd Ion activity measuring apparatus
JP2002346355A (en) * 2001-05-28 2002-12-03 Fuji Electric Co Ltd Micro-mixer
AU2003280660A1 (en) * 2002-11-01 2004-05-25 Arkray, Inc. Measuring instrument provided with sold component concentrating means
JP2007071711A (en) * 2005-09-07 2007-03-22 Fujifilm Corp Analytic chip
JP2007085819A (en) * 2005-09-21 2007-04-05 Citizen Watch Co Ltd Thermochemical inspection device and reaction chip for the thermochemical inspection device

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