JP2008285463A - Therapeutic agent for arthropathy, rheumatism and collagen disease - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To prepare medicines of nucleic acid preparations, because genetic diseases are not cured without using the nucleic acid preparations as the therapeutic agent. <P>SOLUTION: Inventors thought that diseases of unexplained origin in which the treatment is unknown are deeply concerned in hormones. Therefore, the treatment must be carried out by preparing a nucleic acid preparation. It is required that the treatment of genetic diseases is carried out by using a nucleic acid. Further, research corresponding to DNA is expected and improvement of orthopedic surgery is desired. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

For diseases related to arthropathy (Heberden tuberculosis), rheumatism, and collagen disease, nucleic acid preparations are necessary for genetic diseases.

Chemicals that strengthen joints, bones and muscles must be used.

Collagen, chondroitin, glucosamine and hyaluronic acid cartilage components must be supplemented.

Many amino acid preparations are required to regenerate the portion of the cartilage that is worn away.

Vitamin preparations are also required.

You need lots of supplements, including royal jelly, as well as garlic, which seems to be beneficial.

Since these diseases occur because immune functions do not work, drugs that increase immunity are required.

You must study even cytology.

Gene (DNA) therapy is a method that uses "gene DNA" as a medicine to treat diseases.
The world's first gene therapy was performed in 1990 in the United States for patients with adenosine aminase (ADA) deficiency, an inborn metabolic disease that causes severe immunodeficiency.
Gene therapy in Japan has been implemented since 1995 for ADA deficiency and several types of cancer.

Type II collagen, which is also a cartilage component, is active type II collagen, glucosamine is a shrimp crab powder, chondroitin is a shark cartilage, and various supplements are needed as pain relievers.

Rheumatoid arthritis is a systemic inflammatory disease whose main symptom is multiple joint pain and is characterized by immune abnormalities. Heberden's nodule is inflamed in the first joint part of the finger of the hand, and rheumatism is also characterized by inflammation in the second joint part. Rheumatoid arthritis is accompanied by inflammatory cell infiltration of the synovium, proliferation of synovial cells, stratification and angiogenesis, and the destructive changes of articular cartilage, bone, periosteum, ligament and tendon progress.
Interaction with macrophage-like A type synovial cells, fibrocyte-like B type synovial cells, and various inflammatory cells activates synovial cells, forming pannus, the granulation tissue of the synovium Cause cartilage and bone destruction. If inflammation persists, it will cause joint destruction and deformation, and eventually dysfunction. In addition, various extra-articular symptoms associated with pulmonary fibrosis, amyloidosis and vasculitis may occur.

The pathogenesis of rheumatoid arthritis is thought to involve genetic factors and environmental factors that are complex and intertwined to induce an inflammatory response, but there are many unclear points regarding the onset mechanism.
Known as a genetic factor is that there are many patients with specific MHC class II such as HLA-DR4, HLA-DRI and the like. This suggests that T cells restricted to MHC class II may be involved in the development of arthritis. As an environmental factor, it is thought that infections such as viruses and bacterial mycoplasma are the triggers.

In the conventional treatment of rheumatism, there is a problem that the effect is reduced and the side effect is increased in the long term. Therefore, multi-drug combination therapy is also being tried. The idea is that side effects can be reduced because the dose of each drug can be reduced by using drugs with different mechanisms of action.
In addition, new drugs such as anti-cytokine therapy, oral peptide therapy, antisense therapy, and treatment with anti-adhesion molecules are being developed.

It is known that certain amino acids have anti-inflammatory and anti-rheumatic effects.
Ajinomoto Co., Inc. has reported that ornithine and branched chain amino acids have excellent effects in the treatment / prevention of arthritic diseases, improvement in prevention of progress, and the like. Arginine and its derivatives are also known to have antirheumatic effects.
Humans are biped animals. Finally, humans age at their hips, knees and legs. In that sense, chondroitin (shark cartilage) works as a cushion together with glucosamine (shrimp, crab powder). Gives water retention and elasticity to cells in a form combined with protein. It also has various characteristics related to digestion and absorption of nutrients and metabolism. It accounts for 27% to 48% of the cartilage component and maintains the elasticity and smoothness of joints, ligaments and tendons. It is a component that is often produced in the body when you are young, but it decreases rapidly after you are over 20 years old. It keeps youthful skin like glucosamine. Glucosamine is the main component that makes cartilage, ligaments, joint tissues, etc., and smoothes joint movement. It is also used for cosmetic purposes such as sagging skin and wrinkles. And by combining chondroitin and glucosamine, hyaluronic acid Na is made, and it plays a role in preventing the cartilage part from being worn out. However, not only this, but there is collagen in the cartilage part. Collagen is one of the proteins, especially in the skin and accounts for about 70% of the proteins that make up the skin. It is said to be the most important nutrient for our body's metabolism. Collagen also has a function to connect cells of living organisms. There are more than 10 types of collagen. Among them, type II collagen exists in the cartilage component, and type I collagen in the skin is contained in pork and fish. Type II collagen is an active, non-denatured, pure type II collagen from chicken breast cartilage that is quickly absorbed by the body without losing its original activity, helping to regenerate bone and cartilage. And it will lead to a better direction for rheumatic diseases and joint diseases. Necessary component MSM (methylsulfonylmethane) is an organic sulfur compound that is indispensable as a natural nutritional component in almost all living organisms (humans, animals, plants). It has characteristics that are easily absorbed and used in cells, prompts the release of harmful substances, and facilitates the uptake of nutrients, thus improving various symptoms. US patents [564581, 5537321, 5529786, 5750144] active type II collagen (UCII) is already widely known in the United States, and many people have tried it and received high praise. And it is the ingredient that the world pays most attention to. A clinical trial by Harvard University School of Medicine and German research institutes has confirmed the excellent results of active type II collagen (UCII) and has obtained four patents. About 60% of the human body is water. And it consists of about 60 trillion cells. Within the cell, there is a nucleus and a set of chromosomes derived from parents. Necessary genetic information is written on each chromosome in the form of DNA (deoxyribonucleic acid). As a function of DNA, DNA replicates and synthesizes proteins using RNA, so that we do our daily life without rest. DNA replicates itself during cell division. First, the double helix of DNA is unwound and becomes a single DNA. Nucleotides with bases whose bases correspond to DNA bases (conjugates of sugars, phosphates, and bases) are combined with DNA to align the nucleotides and repair the double helix. When protein is synthesized, RNA (ribonucleic acid) of the sequence corresponding to the DNA base sequence is made. This is called transcription. RNA exits the nucleus, becomes messenger RNA, and travels to the ribosome in the cell. Transfer RNA binds to an amino acid, and the one corresponding to the base sequence of messenger RNA connects the amino acid. By combining amino acids, various proteins that make up the human body are created. And there are three base sequences (codons) that are the basis of protein synthesis, meaning of starting decoding (AUG) and end of decoding (UAA, UAG, UGA). Modern people tend to be acidic due to the environment, stress, and meat-centered meals. Then, cells are easily oxidized and metabolism is lowered. Ingestion of alkaline ionized water as an anti-oxidant and anti-aging drinking water will get rid of active oxygen.

In order to regenerate the cartilage part that is worn down, a nucleic acid preparation is used to synthesize a protein.

Means to solve the problem

Ingesting chondroitin, glucosamine, sodium hyaluronate and collagen (UCII), which are cartilage components

Since these diseases are very painful, we use supplementary cat's claw extract and dried willow extract as analgesics. Use hormones that are most effective for pain.

DNA (nucleic acid) is used for protein synthesis.

Uses components related to DNA.

Use all amino acids that bind to RNA.

Use all vitamins.

Use oxoamidine powder and odorless garlic powder, both garlic ingredients.
Uses ingredients contained in odorless garlic powder.
Sorginine glycoside, scormine, thiocolmine, scordi A and B, allicin, creatinine, VB ₁ , VB ₂ VC, nayacin, homotistin, methionine, S adenosylmethionine, SS bond (benzothiamine, disulfide) organic germanium Use

▲１▼錠剤 １日量
活性ＩＩ型コラーゲン（鶏胸軟骨より抽出）低温処理……５ｇ
キャッツクローエキス……６００ｍｇ
西洋ヤナギ乾燥エキス……１．５ｇ

亜鉛酵母（ビール酵母）……１８７．５ｍｇ
マンガン酵母（ビール酵母）……１５０ｍｇ
ＭＳＭ……３６００ｍｇ（ショック死防止）
プレマリン錠……５ｍｇ →男性の関節症には男性ホルモン剤使用のこと。
核酸（ＤＮＡ）……８ｇ
ＲＮＡポリメラーゼ……８ｇ
ヌクレオチド（糖・リン酸・塩基）…８ｇ（免疫力強化）
ムチン……１ｇ
ビオヂァスターゼ２０００……２４ｍｇ
コエンザイムＱ１０……１０ｍｇ
ガンマオリザノール…３０ｍｇ
ＡＴＰ……５０ｍｇ
αリポ酸……２００ｍｇ
スーパーオキシドジスムターゼ（ＳＯＤ）……１ｇ
インシュリン様増殖因子（ＩＧＦの受容レセプター）…１ｇ（長寿酵素）
海草カルシウム末…８００ｍｇ
ＶＤ_２……９．１μｇ
ヒアルロン酸Ｎａ……２３ｍｇ
ホスファチジルコ酸……４５０ｍｇ
リン脂質……５００ｍｇ
レキソタン錠……２ｍｇ（ショック死防止精神安定剤）
カルニチン……２ｇ
〔添加物〕ヒドロキシプロピルセルロース、ステアリンＭｇ ラウレル硫酸Ｎａ、硬化油 カルメロースＣａ メタクル酸コポリマーＬＤ ポリソベット８０ クエン酸トリエチル・タルク 酸化チタン、セルロース バレイショデンプン、ショ糖エステル
▲２▼液体 １日量
硝酸チアミンＶＢ_１…２０ｍｇ
オキソアミジン末……３１５ｍｇ
ＶＢ_２リン酸エステル…２３ｍｇ
ＶＢ_６塩酸ピリドキシン…５５ｍｇ
ＶＥ酢酸エステル……６００ｍｇ
ＶＥα−トコフェノール……１００ｍｇ
ニコチン酸アミド……５５ｍｇ
コンドロイチン酸Ｎａ……８００ｍｇ
ＶＢ_１２剤シアノコバラミン……１７０μｇ
反畠チンキ……１００ｍｇ
シベットチンキ……２５０ｍｇ
ゴオウチンキ……２５０ｍｇ
西洋サンザシエキス……３ｍｇ
ニンジン乾燥エキス……１０ｍｇ
ローヤルゼリー…１００ｍｇ
マカ濃縮エキス……２００ｍｇ
〔添加物〕
安息香酸Ｎａ
ｄｌ−リンゴ酸
ポリオキシエチレン硬化ヒマシ油
パラベン
カラメル
ＰＨ調整剤
香料
グリセリン
アルコール（０．９ｍｌ以下）
▲３▼錠剤（アミノ酸製剤）１日量
ムコ多糖蛋白複合体…１０ｇ
グルタミン酸Ｎａ……５ｇ
アスパラギン酸……１５３０ｍｇ
Ｎａ……２１６ｍｇ
イソロイシン……５ｇ
ロイシン……５ｇ
バリン……５ｇ
アルギニン……３ｇ
グリシン……２ｇ
プロリン…７２０ｍｇ
トレオニン……３ｍｇ
フエニルアラニン……７０５ｍｇ
アラニン……１ｇ
スレオニン……５７０ｍｇ
リジン……１．０２ｇ
ヒスチジン……３６０ｍｇ
トリプトファン…１９５ｍｇ
セリン……６９０ｍｇ
シスチン……２５５ｍｇ
チロシン……５１０ｍｇ
γアミノ酸（ＧＡＢＡ）…６．４ｍｇ
オルニチン……１ｇ
クレアチン……１ｇ
サム・イー（ＳＡＭｅ）……６００ｍｇ
アミノエチルスルホン酸（タウリン）…１６５ｍｇ
ウルソデオキシコール酸…１０ｍｇ
▲４▼錠剤（Ｖ類）
ＶＡ油……１９７５ｍｇ（ＶＡとして２０００ＩＵ）
ＶＢ_１チアミン……１１０ｍｇ
ＶＭ（葉酸）……４０５μｇ
ＶＢ_１２活性型メコバラミン……１５００μｇ
ＶＢ_６塩酸ピリドキシン……５ｍｇ
オースファジルセリン……５０ｍｇ
ビンカイマー抽出物……４０ｍｇ
ＶＣ……６５０ｍｇ
ビオチン……６０μｇ
ナイアシン……１０ｍｇ
酢酸ｄ−ｌ−トコフェロール（天然ＶＥ）……７００ｍｇ
イノシトールヘキサンコネート……１００ｍｇ
無臭ニンニク末（指定したもの）……３００ｇｍ
ＶＥコハク酸エステルＣａ……１０．３６ｍｇ
α−リノレン酸……２００ｍｇ
γ−リノレン酸……５００ｍｇ（ＧＬＡ）
〔添加物〕
タルク、炭酸Ｃａ、トウモロコシデンプン
乳糖、ヒドロキシプロピルセルロース
ヒドロキシプロピルメチルセルロース
二酸化ケイ素、白糖、プルラン、ポビドン
マクロゴール・セルロース・Ｄ−マンニトール
カルナウパロウ ステアリン酸Ｍｇ、グリコール
ラウリン酸ソルビタン ポリソルベート８０
サラシミツロウ ゼラチン グリセリン
Ｄ−ソルビトール サフラワー油
酸化チタン
▲５▼錠剤
Ｂカロテン（抹茶粉末より抽出）……２２５０μｇ
ＤＨＡ……２４０ｍｇ
ＥＰＡ……１００ｍｇ
セサミン……１０ｍｇ
亜鉛ビール酵母……９ｍｇ
銅ビール酵母……０．６ｍｇ
ＶＥ…２７ｍｇ
アントシアニン（カシスより抽出）……５０ｍｇ
ルティン……２０ｍｇ
イチョウ葉エキス…１２０ｍｇ
Ｎａ……８ｍｇ
ウコン（沖縄産）……１０ｍｇ
オメガ脂肪酸……８００ｍｇ
ＶＤ_３……１０μｇ（コレカルシフェロール）
塩酸リジン……１２０ｍｇ
炭酸Ｍｇ……１１８．４ｍｇ
レシチン……５０ｍｇ
スクワレン……３６０ｍｇ
アラキドン酸……２４０ｍｇ
イノシトール……１００ｍｇ
エンカンプーレ……２５０ｍｇ
沈降炭酸Ｃａ……５ｍｇ
〔添加物〕
ダイズ油、ＢＨＴ、ＢＨＡ、
ソルビタン脂肪酸エステル
ゼラチン 安息香酸Ｎａ
デヒドロ酢酸Ｎａ
白糖・Ｄ−マンニトール
硬化油・ステアリン酸ポリオキシル
ステアリン酸Ｍｇ・トウモロコシデンプン
ヒドロキシプロピル・セルロース
▲６▼粉ミルクを薬品として飲用
明治ステップ栄養バランスアップミルク １日２〜３回食事と共にスプーン４〜５杯

▲７▼液体 １日量
ぶどう糖加糖液糖
シルクアミノ酸（絹タンパク分解物）コラーゲンの素…０．５ｇ
魚由来コラーゲンアミド……１０ｇ
プロティン……３ｇ
ＶＣ……５００ｍｇ
ナイアシン……１２ｍｇ
Ｌ−カルニチン……１０ｍｇ
超分子コラーゲン（分子量平均５００）……５００ｍｇ
ピクノジェール……３０ｍｇ
リコピン……３ｍｇ
サポニン……５ｍｇ
システィンペプチド……２０ｍｇ
小麦セラミド……６．５ｍｇ
タンポポ粉末……９０ｍｇ
アンセリンペプチド……５００ｍｇ
テアニン……７０ｍｇ
〔添加物〕
溶性ＶＰ……３ｍｇ

▲８▼アルカリイオン水の製造
ポカリスエットとダカラの混合物イオン水をつくる。
エネルギー４４ｋｃａｌ＋１７ｋｃａｌ＝６１ｋｃａｌ
Ｍｇ……６．６ｍｇ＋６ｍｇ＝１２．６ｍｇ
Ｃａ……１９ｍｇ＋１７ｍｇ＝３６ｍｇ
Ｋ……７０ｍｇ＋５０ｍｇ＝１２０ｍｇ
Ｎａ……４９ｍｇ
糖質４．２ｇ＋４．２ｇ＝８．４ｇ
食物繊維０．４ｇ＋０．４ｇ＝０．８ｇ
炭水化物６．７ｇ

A treatment for arthropathy, rheumatism, and collagen disease.
This treatment is limited to postmenopausal women.
Diabetics are prohibited. Patients with liver disease should be taken in consultation with a doctor.
For patients with young arthropathy, rheumatism, and collagen disease

(1) Tablet Daily active type II collagen (extracted from chicken breast cartilage) Low-temperature treatment ... 5g
Cat's claw extract …… 600mg
Western willow extract ... 1.5g

Zinc yeast (beer yeast) ... 187.5mg
Manganese yeast (beer yeast) ... 150mg
MSM …… 3600mg (shock death prevention)
Premarin Tablets ... 5mg → Use male hormones for male arthropathy.
Nucleic acid (DNA) ...... 8g
RNA polymerase …… 8g
Nucleotides (sugar, phosphate, base) ... 8g (Immunity enhancement)
Mucin …… 1g
Biodiastase 2000 …… 24mg
Coenzyme Q10 …… 10mg
Gamma oryzanol ... 30mg
ATP ... 50mg
Alpha lipoic acid ... 200mg
Superoxide dismutase (SOD) …… 1g
Insulin-like growth factor (IGF receptor) ... 1 g (longevity enzyme)
Seaweed calcium powder ... 800mg
VD ₂ ...... 9.1μg
Hyaluronic acid Na …… 23mg
Phosphatidylcoic acid ... 450mg
Phospholipid …… 500mg
Lexotan Tablets ...... 2mg (Shock death prevention tranquilizer)
Carnitine …… 2g
[Additives] Hydroxypropylcellulose, Stearic Mg Laurel sulfate Na, Hardened oil Carmellose Ca Methacrylic acid copolymer LD Polysovet 80 Triethyl citrate Titanium citrate Titanium oxide, cellulose Potato starch, sucrose ester (2) Liquid Daily dose Thiamine nitrate VB ₁ ... 20mg
Oxoamidine powder ... 315mg
VB ₂ phosphoric acid ester ... 23mg
VB ₆ pyridoxine hydrochloride ... 55mg
VE acetate ... 600mg
VEα-tocophenol …… 100mg
Nicotinamide ... 55mg
Chondroitin acid Na ...... 800mg
VB ₁₂ agents cyanocobalamin ... 170μg
Ruminant tincture ... 100mg
Civet tincture ... 250mg
Gourd tincture ... 250mg
Western hawthorn extract ... 3mg
Carrot dry extract ... 10mg
Royal jelly ... 100mg
Maca concentrate ... 200mg
〔Additive〕
Benzoic acid Na
dl-malic acid polyoxyethylene hydrogenated castor oil paraben caramel PH adjuster fragrance glycerin alcohol (0.9 ml or less)
(3) Tablet (amino acid preparation) daily dose mucopolysaccharide protein complex ... 10 g
Glutamate Na …… 5g
Aspartic acid ... 1530mg
Na …… 216mg
Isoleucine 5g
Leucine ... 5g
Valine 5g
Arginine 3g
Glycine …… 2g
Proline… 720mg
Threonine 3mg
Phenylalanine ... 705mg
Alanine …… 1g
Threonine 570mg
Lysine ... 1.02g
Histidine …… 360mg
Tryptophan ... 195mg
Serine 690mg
Cystine ... 255mg
Tyrosine …… 510mg
γ amino acid (GABA): 6.4 mg
Ornithine …… 1g
Creatine …… 1g
Sam e ... 600mg
Aminoethylsulfonic acid (taurine) ... 165mg
Ursodeoxycholic acid ... 10mg
(4) Tablet (Class V)
VA oil: 1975 mg (2000 IU as VA)
VB ₁ thiamine …… 110mg
VM (folic acid): 405 μg
VB ₁₂ active mecobalamin …… 1500μg
VB ₆ pyridoxine hydrochloride …… 5mg
Aosefadylserine …… 50mg
Binkaima extract ... 40mg
VC …… 650mg
Biotin …… 60μg
Niacin …… 10mg
Dl-Tocopherol acetate (natural VE) ... 700mg
Inositol hexaneconate ... 100mg
Odorless garlic powder (specified) …… 300gm
VE succinate Ca …… 10.36mg
α-Linolenic acid ... 200mg
γ-Linolenic acid: 500 mg (GLA)
〔Additive〕
Talc, carbonic acid carbonate, corn starch lactose, hydroxypropylcellulose hydroxypropylmethylcellulose silicon dioxide, sucrose, pullulan, povidone macrogol, cellulose, D-mannitol carnauba wax, stearate Mg, glycol laurate sorbitan polysorbate 80
White beeswax Gelatin Glycerin D-sorbitol Safflower oil Titanium oxide (5) Tablet B Carotene (extracted from powdered green tea powder) ... 2250μg
DHA …… 240mg
EPA ... 100mg
Sesamin …… 10mg
Zinc beer yeast ... 9mg
Copper beer yeast ... 0.6mg
VE ... 27mg
Anthocyanin (extracted from cassis) ... 50mg
Rutin ... 20mg
Ginkgo biloba extract ... 120mg
Na ...... 8mg
Turmeric (Okinawa) …… 10mg
Omega fatty acid ... 800mg
VD ₃ …… 10μg (cholecalciferol)
Lysine hydrochloride ... 120mg
Mg carbonate …… 118.4mg
Lecithin …… 50mg
Squalene ... 360mg
Arachidonic acid ... 240mg
Inositol ... 100mg
Encampure …… 250mg
Precipitated carbonate Ca ... 5mg
〔Additive〕
Soybean oil, BHT, BHA,
Sorbitan fatty acid ester gelatin benzoic acid Na
Dehydroacetate Na
Sucrose, D-mannitol hydrogenated oil, Mg stearate polyoxyl stearate, corn starch hydroxypropyl, cellulose (6) Drinking powdered milk as a medicine Meiji Step Nutrition Balanced Milk 4-5 spoons with meal 2-3 times a day

(7) Liquid Daily Glucose Sugar Liquid Sugar Silk Amino Acid (Silk Proteolysate) Collagen Element ... 0.5g
Fish-derived collagen amide ... 10g
Protein …… 3g
VC …… 500mg
Niacin …… 12mg
L-carnitine ... 10mg
Supramolecular collagen (molecular weight average 500) 500mg
Pycnoller ... 30mg
Lycopene …… 3mg
Saponin …… 5mg
Cysteine peptide ... 20mg
Wheat ceramide ... 6.5mg
Dandelion powder ... 90mg
Anserine peptide ... 500mg
Theanine: 70mg
〔Additive〕
Soluble VP …… 3mg

(8) Manufacture of alkaline ionized water Make Pocari Sweat and Dakara mixture ionic water.
Energy 44kcal + 17kcal = 61kcal
Mg ...... 6.6mg + 6mg = 12.6mg
Ca ...... 19mg + 17mg = 36mg
K ...... 70mg + 50mg = 120mg
Na ...... 49mg
Carbohydrate 4.2g + 4.2g = 8.4g
Dietary fiber 0.4g + 0.4g = 0.8g
Carbohydrate 6.7g

The invention's effect

I have Heberden tuberculosis. There is an effect.
I don't think there are any side effects because I am a drug allergy.

There is one pharmaceutical company in Japan that produces active collagen type II.
I think that the company will do its best to manufacture.

There are five supplements in Japan that contain nucleic acid DNA preparations.
There are three companies that manufacture nucleic acid preparations in Japan.

I think the industry will greatly develop for Japan. By making nucleic acid preparations, I hope that the elderly will be well-healed, the working population will increase, and a system to work can be created.

It is a cell structure diagram. Cell division occurs by repeating a certain cycle, such as cell division → interphase → DNA synthesis → interphase → cell division. The cycle varies depending on the cell type.

Explanation of symbols

A Nucleolus B Nucleus C Nuclear membrane D Ribosome E Smooth endoplasmic reticulum F Central corpuscle G Rough endoplasmic reticulum H Mitochondria I Golgi apparatus

Claims (1)

To supplement the worn cartilage of arthropathy (Heberden's nodule) rheumatism / collagenous disease with collagen, chondroitin, glucosamine, hyaluronic acid, and to regenerate it to increase nucleic acid preparation (DNA), hormones, autoimmunity A therapeutic drug with nucleotides added.

Images