JP2008197091A - Analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an analyzer capable of obtaining high-precision analysis results for any analysis purpose. <P>SOLUTION: The analyzer 1 dispenses a reagent corresponding to an analysis item for an analyte dispensed in a reaction vessel 21, and analyzes the analyte from an optical characteristic of a reaction liquid of the analyte and the reagent. In the analyzer 1, an analysis processing is carried out for each analysis item in an analysis condition corresponding to the analysis purpose. Accordingly, the high-precision analysis results can be obtained for any analysis purpose by using the analyzer 1. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an analyzer that dispenses a reagent corresponding to an analysis item to a sample dispensed in a reaction container and analyzes the sample based on the optical characteristics of a reaction solution of the sample and the reagent.

  Conventionally, as a device for automatically analyzing a specimen such as blood or body fluid, a specimen and one or more types of reagents are dispensed into a reaction container, and after a chemical change between the specimen and the reagent occurs, There is known one that automatically analyzes a sample by measuring the absorbance of the reaction solution. In such an analyzer, the concentration of the detection target is analyzed using a change in absorbance corresponding to the concentration of the detection target in the reaction solution. For example, when there are many detection objects contained in the sample, a large amount of reaction product between the reagent and the sample is generated in the reaction solution, and light is absorbed by the generated reaction product, resulting in an increase in absorbance. When the detection target contained in the sample is small, the occurrence of a reaction product between the reagent and the sample in the reaction solution is small, and the absorbance is also low.

  In a general analyzer, predetermined analysis conditions are set for each item to be analyzed. In the conventional analyzer, if the absorbance of the reaction solution exceeds the measurable range under the set analysis conditions, the sample dispensing volume is changed to a condition that reduces the sample solution so that the absorbance of the reaction solution satisfies the measurable range. Then, the analysis process is performed again (see Patent Document 1). Further, in the conventional analyzer, since there is a difference in the absorbance measurement range between serum and urine, which are specimens, analysis processing is performed by changing the analysis conditions according to the specimen type (see Patent Document 2). ). Moreover, in the conventional analyzer, the analysis process is changed according to the age, sex, sample collection time, etc. of the patient who provided the sample (see Patent Document 3). As described above, in the conventional analyzer, the analysis conditions are changed according to reanalysis, sample type, or sample provider information to achieve more accurate analysis processing.

Japanese Patent Laid-Open No. 10-282106 JP-A-9-61435 JP-A-6-27117

  Such analyzers are installed not only in medical periods such as hospitals, but also in so-called examination centers that specialize in examinations, and generally the same analysis conditions are applied to any specimen regardless of the examination purpose. It is analyzed using. In other words, the analysis device is a diagnostic test (hereinafter referred to as a general diagnostic test) that is performed on a patient who feels abnormal in the body and visits a medical institution. For example, the same analysis conditions are used in a health check purpose inspection (hereinafter referred to as a health check-up test) performed by taking a medical examination based on the regulations of the place of work or school.

  Among these, in general diagnostic tests, a sample may contain a lot of detection objects, and the absorbance of the reaction solution may greatly exceed the reference range indicating that it is healthy. For this reason, in the analyzer, the analysis conditions are set so that a wide range greatly exceeding the reference range can be analyzed. For example, based on a sample that contains a large amount of detection target that greatly exceeds the reference range, sample dispensing is performed so that the absorbance of the reaction solution between the sample and the reagent is low enough to be within the measurable range of the photometric mechanism. The amount is set to a very small volume to suppress the amount of reaction product generated between the specimen and the reagent. Therefore, in the conventional analyzer, a minute volume of sample is dispensed into the reaction container so that a wide range greatly exceeding the reference range can be analyzed corresponding to the general diagnostic test.

  In contrast to the general diagnostic test, generally, in the health diagnostic test, the detection target contained in the sample is generally in a very small amount. For this reason, in the health examination, the absorbance of the reaction solution often shows values corresponding to the reference range and the vicinity of the reference range. As described above, since the measurement range of the photometric mechanism corresponds to a wide range that greatly exceeds the reference range in correspondence with the analysis possible range, the absorbance of the reaction solution corresponding to the reference range and the region near the reference range is measured range. In some cases, it is difficult to ensure high accuracy in the analysis results in the health examination.

  Hereinafter, the accuracy in the health examination will be described. Conventionally, even in a health examination for a specimen containing a trace amount of detection object, a trace quantity of specimen is dispensed, as in the case of a general diagnostic examination. For this reason, in the case of health checkups that mainly measure the concentration in the reference range and in the vicinity of the reference range, the amount of reaction product produced is also compared with general diagnostic tests that may measure concentrations that greatly exceed the reference range. However, the amount becomes extremely small, and the absorbance component proportional to the amount of the reaction product also becomes low. In general, the absorbance obtained by the measurement includes a noise component in addition to the absorbance component corresponding to the original absorbance. In the case of a health checkup test, the original absorbance component was remarkably low, and as a result of dispensing a small volume of sample as in the case of a general diagnosis test, only an absorbance measurement value with a high ratio of noise components was obtained. Therefore, in the health examination, since analysis is performed based on absorbance measurement that is strongly influenced by noise components, it is difficult to maintain high analysis accuracy. In addition, in a dispensing mechanism, in general, the smaller the dispensing amount, the greater the effect of variation in dispensing, making it difficult to maintain dispensing accuracy. For this reason, in the medical examination, since a sample containing a small amount of a detection target is dispensed, there is a possibility that the analysis result may be affected to the extent that the variation in the dispensed amount cannot be ignored.

  Therefore, it has been difficult for conventional analyzers to obtain highly accurate analysis results in health examinations in which analysis results are concentrated in the reference range and near the reference range, which are near the lower limit region of the measurement range. As a result, in conventional analyzers, it may be difficult to achieve the original purpose of a health check-up test for finding signs of disease on the basis of slight changes in test values of healthy subjects. In addition, the concentration of each component of the reagent used for analysis is adjusted to the concentration required for reaction with the concentration of the detection target that greatly exceeds the reference range, and the detection target in the vicinity of the reference range, such as the test target in a health checkup It can be said that it is an excessive concentration with respect to the object concentration. As a result, reagent costs are also increased.

  The present invention has been made in view of the above-mentioned drawbacks of the prior art, and provides an analyzer capable of obtaining a highly accurate analysis result for any analysis purpose, and performs or implements a health checkup test. The purpose is to reduce the inspection cost by using a low-cost reagent.

  In order to solve the above-described problems and achieve the object, an analyzer according to the present invention dispenses a reagent according to an analysis item to a sample dispensed in a reaction container, and reacts the sample with the reagent. An analysis apparatus for analyzing a sample based on the optical characteristics of a liquid is characterized in that an analysis process is performed for each analysis item under an analysis condition corresponding to an analysis purpose.

  The analysis apparatus according to the present invention includes a storage means for storing analysis conditions corresponding to each analysis purpose for each analysis item, and an analysis condition corresponding to the analysis purpose of the sample to be analyzed for each analysis item. From the storage means, and setting means for setting the acquired analysis condition as an analysis condition for the sample to be analyzed, and each part in the analyzer according to the analysis condition set for each analysis item by the setting means And a control means for controlling.

  The analysis apparatus according to the present invention further includes an input means for inputting the analysis purpose of the sample that is the analysis target, and the setting means is used for the analysis purpose of the sample that is the analysis target input by the input means. A corresponding analysis condition is acquired from the storage means, and the acquired analysis condition is set as an analysis condition that is the analysis target.

  In the analyzer according to the present invention, the analysis purpose is a health diagnosis purpose or a general diagnosis purpose.

  The analyzer according to the present invention further includes a photometric means for measuring the optical characteristics of the reaction solution, and the analysis condition corresponding to the health diagnosis purpose is higher than the analysis condition corresponding to the general diagnosis purpose. And / or conditions for increasing the amount of reaction between the reagent and / or conditions for increasing the photometric sensitivity of the photometric means, wherein the measurement range of the optical property by the photometric means is the analysis condition corresponding to the general diagnostic purpose. The condition is that the measurement range is narrower than the reference range including the reference range indicating that it is healthy.

  The analysis conditions of the analyzer according to the present invention are as follows: for each analysis item, sample dispensing amount, sample dilution rate, reagent dispensing amount, reagent concentration, reagent dilution rate, photometric wavelength for the reaction solution, reaction solution At least one of the reaction time and the measurement time for the reaction solution differs depending on the purpose of analysis.

  The analysis apparatus according to the present invention further includes a determination unit that determines whether or not an analysis result in the analysis item instructed to be analyzed is normal, and the control unit includes the analysis purpose as the health check purpose. If the analysis is instructed, the analysis unit is caused to execute an analysis process for the analysis item for comparison in which the analysis result does not change by comparing the analysis with the analysis result of the instructed analysis item together with the analysis item instructed for analysis. Is instructed to perform the analysis if the analysis result in the comparative analysis item has changed compared to the analysis result in the comparative analysis item that has already been performed on the sample to be analyzed. The analysis result of the analysis item is abnormal, that is, it is determined that the analysis result is not correct.

  In the analysis apparatus according to the present invention, the analysis item for comparison is an analysis item in which the analysis result has little variation within and between individuals, and the determination means includes the analysis result in the analysis item for comparison. If there is a change compared to the analysis result in the analysis item for comparison that has already been performed on the sample to be analyzed, the sample to be analyzed has an abnormality, that is, sample pretreatment, etc. It is characterized by determining that there is a problem in handling.

  In the analysis apparatus according to the present invention, the analysis item for comparison is an analysis item in which the analysis result varies greatly between individuals, and the determination means includes the analysis result in the analysis item for comparison as the analysis target. If there is a change compared to the analysis result in the comparative analysis item that has already been performed on the sample, it is determined that the sample to be analyzed may be mistaken for another sample. It is characterized by.

  In the analysis apparatus according to the present invention, the analysis process can be performed under the analysis conditions according to the analysis purpose for each analysis item, that is, the analysis conditions suitable for the analysis purpose. Can be obtained.

  Hereinafter, with reference to the drawings, an analyzer that is an embodiment of the present invention will be described by way of example of an analyzer that performs biochemical analysis on a sample such as blood or urine. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals.

(Embodiment 1)
First, the first embodiment will be described. In the first embodiment, the analysis accuracy is improved by performing an analysis process under an analysis condition corresponding to the analysis purpose for each analysis item. FIG. 1 is a schematic diagram illustrating the configuration of the analyzer according to the first embodiment. As shown in FIG. 1, the analyzer 1 according to the first embodiment dispenses a sample and a reagent to be analyzed into a reaction vessel 21 and optically measures a reaction occurring in the reaction vessel 21. 2 and a control mechanism 3 that controls the entire analyzer 1 including the measurement mechanism 2 and analyzes the measurement result in the measurement mechanism 2. The analyzer 1 automatically and sequentially performs biochemical analysis for detecting the concentration of the detection target in the sample by the cooperation of these two mechanisms.

  First, the measurement mechanism 2 will be described. The measurement mechanism 2 is roughly divided into a reaction table 10, a first reagent storage 11, a first reagent dispensing mechanism 12, a sample transfer unit 13, a sample dispensing mechanism 14, a second reagent storage 15, a second reagent dispensing mechanism 16, A stirring unit 17, a photometric unit 18, and a cleaning unit 19 are provided.

  The reaction table 10 transfers the reaction container 21 to a predetermined position in order to dispense a sample or reagent into the reaction container 21, to stir, wash or measure the reaction container 21. The reaction table 10 is rotatable about a vertical line passing through the center of the reaction table 10 as a rotation axis by driving a drive mechanism (not shown) under the control of the control unit 31. An openable and closable lid and a thermostat (not shown) are provided above and below the reaction table 10, respectively.

  The first reagent storage 11 can store a plurality of first reagent containers 11 a in which the first reagent to be dispensed first among the two types of reagents dispensed in the reaction container 21 is accommodated. A plurality of storage chambers are arranged at equal intervals in the first reagent storage 11, and a first reagent container 11a is detachably stored in each storage chamber. The first reagent storage 11 is rotated clockwise or counterclockwise around a vertical line passing through the center of the first reagent storage 11 as a driving mechanism (not shown) is driven under the control of the control unit 31. The desired first reagent container 11a is transferred to the reagent aspirating position by the first reagent dispensing mechanism 12. An openable / closable lid (not shown) is provided above the first reagent storage 11. The first reagent storage 11 is kept cold. Therefore, when the first reagent container 11a is stored in the first reagent storage 11 and the lid is closed, the reagent stored in the first reagent container 11a is kept in a cold state, and the first reagent container 11a Evaporation and denaturation of the reagent contained in the container can be suppressed.

  A recording medium on which reagent information related to the reagent stored in the first reagent container 11a is recorded is attached to the side surface of the first reagent container 11a. The recording medium displays various encoded information and is optically read.

  A first reagent reading unit 11 b that optically reads the recording medium is provided on the outer periphery of the first reagent storage 11. The first reagent reading unit 11b emits infrared light or visible light to the recording medium, and reads the information on the recording medium by processing the reflected light from the recording medium. In addition, the first reagent reading unit 11b may capture the recording medium, decode the image information obtained by the imaging process, and acquire the recording medium information.

  The first reagent dispensing mechanism 12 includes an arm 12a to which a probe for aspirating and discharging the first reagent is attached to the tip. The arm 12a freely moves up and down in the vertical direction and rotates around the vertical line passing through its base end as a central axis. The first reagent dispensing mechanism 12 includes a suction / discharge mechanism using a suction / discharge syringe or a piezoelectric element (not shown). The first reagent dispensing mechanism 12 sucks into the probe the reagent in the first reagent container 11a corresponding to the analysis item designated by the sample to be analyzed that has been moved to a predetermined position on the first reagent storage 11. Then, the arm 12a is rotated clockwise in the figure, and the amount set by the analysis condition setting unit 32 is dispensed into the reaction container 21 transported to a predetermined position on the reaction table 10. In general analyzers, a reagent whose concentration has been adjusted is aspirated into a probe and then dispensed in a fixed amount. Using a reagent that has been adjusted to a high concentration in advance, the reagent is pushed out with a diluent such as water at a predetermined ratio during dispensing. There are also devices for dispensing.

  The sample transfer unit 13 includes a plurality of sample racks 13b that hold a plurality of sample containers 13a containing liquid samples such as blood and urine and sequentially transfer them in the direction of the arrows in the figure. The sample in the sample container 13a transferred to a predetermined position on the sample transfer unit 13 is dispensed by the sample dispensing mechanism 14 into the reaction container 21 that is arranged and transported on the reaction table 10. A recording medium on which sample information related to the sample stored in the sample container 13a is recorded is attached to the side surface of the sample container 13a. Sample information includes information on the provider who provided the sample, analysis items instructed to analyze the sample stored in the sample container 13a, and the purpose of analysis of the sample stored in the sample container 13a.

  A sample reading unit 13c that optically reads a recording medium attached to the sample container 13a is provided outside the sample transfer unit 13. Similar to the first reagent reading unit 11b, the sample reading unit 13c emits infrared light or visible light to the recording medium, and reads the information on the recording medium by processing the reflected light from the recording medium. In addition, the sample reading unit 13c may perform image capturing processing on the recording medium, decode image information obtained by the image capturing processing, and acquire information on the recording medium. The sample reading unit 13 c outputs the read sample information to the control unit 31.

  Similar to the first reagent dispensing mechanism 12, the sample dispensing mechanism 14 includes an arm 14a with a probe for aspirating and discharging the sample attached to the tip, and an intake / exhaust mechanism using an unillustrated intake / exhaust syringe or piezoelectric element. Prepare. The sample dispensing mechanism 14 sucks the sample into the probe from the sample container 13a transferred to the predetermined position on the sample transfer unit 13 described above, and turns the arm 14a counterclockwise in the drawing to thereby react the reaction container 21. The amount of specimen moved by the analysis condition setting unit 32 is dispensed.

  The second reagent storage 15 can store a plurality of second reagent containers 15 a in which the second reagent to be dispensed after the sample is dispensed among the two types of reagents dispensed in the reaction container 21. Similar to the first reagent storage 11, the second reagent storage 15 is provided with a plurality of storage chambers in which the second reagent containers 15a are detachably stored. Similar to the first reagent storage 11, the second reagent storage 15 can be rotated clockwise or counterclockwise, and the desired second reagent container 15 a is transferred to the reagent aspirating position by the second reagent dispensing mechanism 16. To do. Similar to the first reagent storage 11, an openable / closable lid (not shown) is provided above the second reagent storage 15, and the second reagent storage 15 is kept cold. Similar to the first reagent container 11a, a recording medium on which reagent information related to the second reagent stored in the second reagent container 15a is recorded is attached to the side surface of the second reagent container 15a. In addition, a second reagent reading unit 15b that has the same function as the first reagent reading unit 11b and optically reads the recording medium attached to the second reagent container 15a is provided on the outer peripheral portion of the second reagent storage 15. It has been.

  Similar to the first reagent dispensing mechanism 12, the second reagent dispensing mechanism 16 uses an arm 16a with a probe for aspirating and discharging the second reagent attached to the tip, and an unillustrated suction / exhaust syringe or piezoelectric element. A reaction table after aspirating the reagent in the second reagent container 15a corresponding to the analysis item designated by the sample to be analyzed that has been moved to a predetermined position on the second reagent storage 15 into the probe. The amount set by the analysis condition setting unit 32 is dispensed into the reaction vessel 21 transported to a predetermined position on 10. Here too, there is an apparatus that uses a reagent that has been adjusted to a high concentration in advance and dispenses it with a diluent such as water at a predetermined ratio during dispensing. The stirring unit 17 stirs the first reagent, the sample, and the second reagent dispensed in the reaction vessel 21 to promote the reaction.

  The photometry unit 18 emits light of a predetermined wavelength to the reaction vessel 21, receives light that has passed through the reaction solution of the reagent and the sample in the reaction vessel 21, performs spectral intensity measurement, and measures the absorbance. The measurement result obtained by the photometry unit 18 is output to the control unit 31 and analyzed by the analysis unit 34. The photometric unit 18 may be configured to irradiate the reaction vessel 21 with white light, and to detect the output of a predetermined wavelength by transmitting the reaction liquid and then performing spectroscopy.

  The cleaning unit 19 performs cleaning by sucking and discharging the liquid mixture in the reaction vessel 21 that has been measured by the photometry unit 18 by using a nozzle (not shown) and injecting and sucking cleaning liquid such as detergent and cleaning water. . The washed reaction vessel 21 is reused. Depending on the contents of the inspection, the reaction vessel 21 may be discarded after completion of one measurement, and a new reaction vessel may be automatically supplied although not shown.

  Next, the control mechanism 3 will be described. The control mechanism 3 includes a control unit 31, an input unit 33, an analysis unit 34, a storage unit 35, an output unit 37, and a transmission / reception unit 38. These units included in the measurement mechanism 2 and the control mechanism 3 are electrically connected to the control unit 31.

  The control unit 31 is configured using a CPU or the like, and controls processing and operation of each unit of the analyzer 1. The control unit 31 performs predetermined input / output control on information input / output to / from each of these components, and performs predetermined information processing on this information.

  The input unit 33 is configured by using a keyboard, a mouse, and the like, and acquires various information necessary for analyzing the specimen, instruction information for analysis operation, and the like from the outside. The analysis unit 34 obtains the concentration of the detection target in the sample based on the absorbance measured by the photometry unit 18 and performs component analysis of the sample.

  The storage unit 35 is configured using a hard disk that magnetically stores information and a memory that loads various programs related to the process from the hard disk and electrically stores them when the analyzer 1 executes the process. Various information including the analysis result of the sample is stored. The storage unit 35 may include an auxiliary storage device that can read information stored in a storage medium such as a CD-ROM, a DVD-ROM, or a PC card. The memory | storage part 35 memorize | stores the analysis conditions according to each analysis objective for every analysis item.

  The output unit 36 is configured using a display, a printer, a speaker, and the like, and outputs various information including the analysis result of the sample. The transmission / reception unit 38 has a function as an interface for performing transmission / reception of information according to a predetermined format via a communication network (not shown).

  Further, the control unit 31 includes an analysis condition setting unit 32. The analysis condition setting unit 32 acquires the analysis conditions according to the analysis purpose of the sample that is the analysis target for each analysis item from the storage unit 35, and sets the acquired analysis conditions as the analysis conditions of the sample that is the analysis target. Here, for the purpose of analysis, general diagnostic purposes for general screening tests conducted on patients who have seen abnormalities in the body and have visited a medical institution, those who have not felt particularly abnormal in the body There is a purpose of health checkup. Among these, the analysis condition corresponding to the health diagnosis purpose is a condition for increasing the reaction amount between the sample and the reagent and / or a condition for increasing the photometric sensitivity by the photometry unit 18 as compared with the analysis condition corresponding to the general diagnosis purpose. The analysis condition corresponding to the health diagnosis purpose is a reference range indicating that the optical characteristic measurement range by the photometry unit 18 is narrower than the measurement range in the analysis condition corresponding to the general diagnosis purpose. This is a condition in which the reference range is included. The analysis conditions corresponding to the health diagnosis purpose are such that the reagent concentration used is lower than the reagent used for the general diagnosis purpose. This analysis condition includes, for each analysis item, the sample dispensing amount, the sample dilution rate, the reagent dispensing amount, the reagent concentration, the reagent dilution rate, the photometric wavelength for the reaction solution of the reagent and the sample, the reaction time in the reaction solution, and the reaction solution At least one of the measurement times for is different for each analytical purpose. The control unit 31 controls each part in the analyzer 1 according to the analysis conditions set for each analysis purpose by the analysis condition setting unit 32. The analysis purpose of the sample to be analyzed is included in the sample information input to the control unit 31 by the sample reading unit 13c. For this reason, the analysis condition setting unit 32 acquires the analysis purpose included in the sample information input from the sample reading unit 13c, and recognizes the analysis purpose of the sample that is the analysis target.

  In the analyzer 1 configured as described above, the first reagent dispensing mechanism 12 dispenses the first reagent in the first reagent container 11a to the plurality of reaction containers 21 that are sequentially transported in a row. Then, after the sample dispensing mechanism 14 dispenses the sample in the sample container 13a and the second reagent dispensing mechanism 16 dispenses the reagent in the second reagent container 15a, the photometric unit 18 removes the sample and the reagent. The spectral intensity of the reacted liquid is measured, and the analysis result is analyzed by the analysis unit 34, so that the component analysis of the specimen is automatically performed. In addition, the cleaning unit 19 cleans the reaction vessel 21 transported after the measurement by the photometry unit 18 is completed, so that a series of analysis operations are continuously repeated.

  Next, analysis condition setting processing by the analyzer 1 will be described. FIG. 2 is a flowchart showing a processing procedure related to the analysis processing in the analysis apparatus 1. As shown in FIG. 2, in the analysis apparatus 1, the analysis condition setting unit 32 determines whether or not analysis instruction information has been received (step S2). The sample information of the recording medium attached to the sample container 13a input to the control unit 31 by the sample reading unit 13c includes the analysis item and the analysis purpose to be performed on the sample. When the sample information is received, the analysis processing of the analysis item included in the sample information is started for the sample. In other words, the sample information corresponds to analysis instruction information that instructs the sample in the sample container 13a to analyze the analysis item included in the sample information.

  The analysis condition setting unit 32 repeats the determination process in step S2 until the sample information corresponding to the analysis instruction information is received. When the analysis condition setting unit 32 determines that the sample information corresponding to the analysis instruction information has been received (step S2: Yes), whether the analysis purpose of the sample to be analyzed is a health diagnosis purpose or not. It is determined whether or not there is (step S4).

  When the analysis condition setting unit 32 determines that the analysis purpose of the sample to be analyzed is the purpose of the health check (step S4: health check), the analysis condition setting unit 32 uses the health check purpose corresponding to the health check purpose for each analysis item from the storage unit 35. Are acquired (step S6). Next, the analysis condition setting unit 32 sets the acquired analysis conditions for health checkup as analysis conditions for the sample to be analyzed (step S8). The control unit 31 performs an analysis control process for controlling each part in the analyzer 1 according to the health diagnosis analysis conditions set by the analysis condition setting unit 32 to perform the analysis process (step S10). And the control part 31 receives the measurement result by the photometry part 18 (step S12), and the analysis part 34 analyzes the received measurement result, and detects the density | concentration etc. of the detection target object in each analysis item (step S14). . Next, the output unit 37 outputs a test result such as the concentration of the detection target detected by the analysis unit 34 (step S16).

  On the other hand, when the analysis condition setting unit 32 determines that the analysis purpose of the sample to be analyzed is the general diagnosis purpose (step S4: general diagnosis), the analysis condition setting unit 32 responds to the general diagnosis purpose for each analysis item from the storage unit 35. The analysis conditions for general diagnosis are acquired (step S26). Next, the analysis condition setting unit 32 sets the acquired analysis conditions for general diagnosis as the analysis conditions for the sample to be analyzed (step S28). The control unit 31 performs an analysis control process for controlling each part in the analyzer 1 according to the analysis conditions for general diagnosis set by the analysis condition setting unit 32 to perform an analysis process (step S30). And the control part 31 receives the measurement result by the photometry part 18 (step S32), and the analysis part 34 analyzes the received measurement result, and detects the density | concentration etc. of the detection target object in each analysis item (step S34). . Next, the output unit 37 outputs an analysis result such as the concentration of the detection target detected by the analysis unit 34 under the control of the control unit 31 (step S36). In this case, the control unit 31 may store the analysis result by the analysis unit 34 in the storage unit 35 or an external storage medium, or may output the result to another external device via a network (not shown).

  And the control part 31 judges whether the analysis process was complete | finished based on the input instruction information (step S38), and when it is judged that the analysis process was complete | finished (step S38: Yes), The analysis process ends. On the other hand, when the control unit 31 determines that the analysis processing has not ended (step S38: No), the process returns to step S2, and the analysis condition setting unit 32 performs step S2 until receiving sample information corresponding to the analysis instruction information. The determination process is performed.

  Next, with reference to FIG. 3, the analysis conditions stored in the storage unit 35 shown in FIG. 1 will be specifically described. FIG. 3 is a diagram illustrating analysis conditions in the analysis item AST. A column L11 in the table T1 shown in FIG. 3 indicates each analysis condition corresponding to the general diagnosis purpose, and a column L12 indicates each analysis condition corresponding to the health diagnosis purpose. As shown in row R11 of FIG. 3, for general diagnostic purposes, the sample dispensing volume, ie the sample volume, is 10 μL. In contrast, for the purpose of health diagnosis, the sample amount is 25 μL, which is larger than the sample amount for general diagnosis purposes. In addition, in the analysis conditions corresponding to the general diagnosis purpose and the health diagnosis purpose, the amount of the reagent is the same. Therefore, as shown in FIG. 3, the analysis condition corresponding to the health diagnosis purpose is a condition for increasing the reaction amount between the specimen and the reagent as compared with the analysis condition corresponding to the general diagnosis purpose. However, “reagent position 2” shown in FIG. 3 is set when a reagent adjusted for AST (health checkup) is used in order to reduce reagent costs, and otherwise “reagent position” is the same as that for AST. Position 1 "is set. When using a reagent whose concentration is lower than that of a reagent used for general diagnostic purposes in accordance with the purpose of health diagnosis, the reagent position is set separately. In an analyzer having a function of using a reagent adjusted to a high concentration in advance and extruding with a diluent such as water at the time of reagent dispensing, as shown in FIG. 4, the first reagent amount, the diluent amount, the second reagent amount, and Set the dilution volume as the analysis condition. In this case, the reagents installed in the apparatus are common and the reagent positions are the same.

  In specimens for health check purposes, the amount of detection target contained in the specimen is almost always small. The analysis conditions corresponding to the purpose of the health check are set such that the amount of sample to be dispensed in the reaction vessel 21 is larger than the analysis conditions for the purpose of the general diagnosis. The amount of reaction product generated can be increased by increasing the amount of reaction between the detection target and the reagent. In other words, the analysis apparatus 1 can generate a large amount of reactants by using the analysis conditions corresponding to the health diagnosis purpose even if the amount of detection target contained in the sample is very small. For this reason, the analysis apparatus 1 uses the analysis conditions corresponding to the purpose of the health diagnosis, so that the amount of the reaction product generated is compared with the conventional case where the sample for the purpose of the health diagnosis is analyzed under the same conditions as the general diagnosis purpose. The absorbance can be increased proportionally. Therefore, according to the analysis conditions corresponding to the health diagnosis purpose, the absorbance component itself corresponding to the reactant is increased, and therefore the influence of the noise component on the absorbance measured by the photometry unit 18 is also reduced. As a result, the analyzer 1 can acquire the absorbance of the reactant with high accuracy by using the analysis conditions corresponding to the purpose of the health check. Thus, the analysis apparatus 1 can improve the analysis accuracy corresponding to a very small concentration of the detection target in the reference range and in the vicinity of the reference range by using the analysis condition corresponding to the health diagnosis purpose. In addition, the reagent cost can be reduced by using a reagent adjusted to a low concentration corresponding to the purpose of health check-up, or by increasing the dilution factor to reduce the amount of reagent used.

  In addition, as shown in FIG. 3, the analysis condition corresponding to the general diagnostic purpose is to set the sample dispensing amount to a very small volume and suppress the amount of reaction product generated between the sample and the reagent. Under the analysis conditions for general diagnostic purposes, even if the sample contains an amount of the detection target that greatly exceeds the reference range, the absorbance of the sample and reagent for the reaction solution is within the photometric range of the photometric mechanism. Therefore, the sample dispensing amount is set to a small volume so that the analysis range is widened. For this reason, the analysis apparatus 1 can accurately perform analysis even on a sample including an amount of a detection target that greatly exceeds the reference range by using analysis conditions for general diagnostic purposes.

  As described above, when the analyzer 1 performs a plurality of examinations for a certain period of time for the same sample provider, which is a general diagnostic purpose, the analysis condition is set so that the analysis possible range corresponding to the general diagnostic purpose can be widened. Use. For this reason, the analyzer 1 can increase the analyzable upper limit of the AST value up to the value Tl1 shown in FIG. 5 for general diagnostic purposes. For this reason, since the analysis possible upper limit value Tl1 is set high, the analyzer 1 provides the sample with a reference range between the reference upper limit value Tu and the reference lower limit value Tf, as indicated by points P11, P12, and P13. Even if the person's AST value greatly exceeds, analysis is possible, and an accurate analysis result can be obtained.

  Conventionally, a specimen containing a small amount of a detection target, which is a health diagnosis purpose, has been examined using the same analysis conditions as those corresponding to the general diagnosis purpose. In other words, in a medical examination for a specimen containing a small amount of detection target, a small volume of specimen is dispensed as in the case of a general diagnostic examination. For this reason, in a sample for health check in which the absorbance measurement value often shows values corresponding to the reference range and the vicinity of the reference range, the detection target contained in the sample is very small. As a result, the absorbance component due to the original reaction was remarkably lowered, and only the absorbance measurement value having a high influence of the noise component was obtained. Therefore, conventionally, as shown by points Pt21, Pt22, and Pt23 in FIG. 5, when the AST value fluctuates up and down with the reference range upper limit Tu as a boundary for each examination, there is no sign of disease on the specimen provider's body. For this reason, it has not been possible to determine whether the AST value fluctuates or whether the AST value fluctuates due to the influence of noise components.

  On the other hand, in the analyzer 1 according to the first embodiment, the condition in which the sample dispensing amount itself is set larger than the analysis condition for the general diagnosis purpose is used as the analysis condition corresponding to the health diagnosis purpose. The absorbance measurement value is increased by increasing the amount of reaction between the detection target and the reagent.

  As a result, the measurable density range becomes narrow, but the range corresponding to the reference range and the region near the reference range occupies a larger range with respect to the measurement range of the photometry unit 18 than before. That is, as shown in FIG. 6, the reference range and the region near the reference range occupy a large range in the analyzable range having the upper limit of the analyzable upper limit value Tl2, and the inspection results located in the reference range and the region near the reference range are detailed. It becomes possible to analyze.

  For this reason, when samples from the same provider are analyzed every certain period, conventionally, only the AST value that is affected by the noise component and fluctuates depending on the number of examinations can be obtained as indicated by points Pt21, Pt22, and Pt23. In the analyzing apparatus 1, as in the points P21, P22, and P23, it is possible to obtain an accurate AST value that substantially corresponds to the original absorbance component in which the influence of the noise component is suppressed. Therefore, according to the analyzer 1, a gradual increase in the AST value can be determined as shown by the straight line 11 passing through the points P21, P22, and P23. It is possible to grasp that there is a possibility of causing liver disease due to an increase in the value in the future. In the analyzer 1, since the analysis result corresponding to the health check purpose can be obtained with high accuracy for the sample that is the purpose of the health check, the analysis result in the reference range and the vicinity of the reference range can be obtained with high accuracy. It is possible to discriminate a slight change in the test value of the person, and the original purpose of the health examination of finding a sign of onset can be achieved.

  Moreover, since the analyzer 1 increases the sample dispensing amount for the purpose of health checkup, it can dispense the sample with a dispensing accuracy that suppresses the influence of dispensing variation. Therefore, the analysis apparatus 1 can reduce the influence of the variation in the sample dispensing amount on the analysis result by using the analysis condition corresponding to the purpose of the health check.

  As described above, in the analysis apparatus 1 according to the first embodiment, analysis processing can be performed for each analysis item under analysis conditions according to the analysis purpose, that is, analysis conditions suitable for the analysis purpose. The analysis result with high accuracy can be obtained.

  Therefore, in the analyzer 1, it becomes possible to monitor a slight change in measured value exceeding the intra-individual variation of the test value of a healthy person with high accuracy in the health check, and the detection of a sign of the onset is compared with the conventional case. Can be done accurately. By using the analysis result in the analyzer 1, it is considered that it is possible to maintain health by improving lifestyle without taking medicine in the stage before the onset of illness.

  Moreover, according to the analyzer 1, since a highly accurate biochemical test is possible, the test result by the biochemical test is also provided to a person who has a risk of developing in the future by the constitution test by the genetic test. In addition, it is possible to monitor the presence or absence of changes in each test value with high sensitivity, and to cope with improvement of lifestyle habits before onset. In addition, by using the analysis result of the analyzer 1, signs of onset can be detected at an early stage, and the onset can be prevented by coping with improvement of lifestyle habits before onset, so that the treatment costs necessary after the onset can be reduced. there is a possibility.

  Thus, by using the analyzer 1, it becomes possible to construct an analysis system that can detect signs of disease from slight changes in test values, and it seems that disease can be avoided by improving lifestyle habits. . In particular, it is considered that the present invention can be applied to a checkup of visceral fat syndrome (metabolic syndrome) aiming to detect signs of heart disease and stroke by monitoring slight changes in each test value.

  In the first embodiment, as shown in FIG. 6, the upper limit for analysis Tl2 for the purpose of health diagnosis is lower than the upper limit for analysis Tl1 for the purpose of general diagnosis shown in FIG. The reference range upper limit value Tu exceeds the predetermined value. In the sample corresponding to the purpose of the health check, since the test result hardly exceeds the reference range, the analysis can be sufficiently performed even when the measurable upper limit Tl2 is set low.

  In the first embodiment, the analysis condition name is shown in the column L11 of FIG. 3 in the case of the general diagnosis purpose so that the analysis condition setting unit 32 can appropriately acquire the analysis condition corresponding to the inspection purpose. In the case of health check purposes, the analysis conditions can be determined for each purpose as “AST (checkup)” shown in column L12 of FIG. In the analysis apparatus 1, even when the analysis condition setting unit 32 acquires the analysis condition of any item name “AST” or “AST (health checkup)”, as shown in FIG. In the inspection item, “AST” which is the original inspection item is shown instead of the item name of the acquired analysis condition. This is because when the acquired item name “AST” or “AST (medical checkup)” of the analysis condition is reflected in the output result as it is, the output contents become complicated, and doctors who refer to the output result are confused.

  In the first embodiment, the analysis conditions shown in FIG. 3 in which the sample dispensing amount is higher than the analysis conditions corresponding to the general diagnosis purpose have been described as the analysis conditions corresponding to the health diagnosis purpose. However, the present invention is not limited to this, and any conditions that increase the reaction amount between the specimen and the reagent may be used.

  For example, as shown in row R22 and row R23 in table T2 of FIG. 8, the amount of the first reagent and the amount of the second reagent for the purpose of health check are reduced from those for the purpose of general diagnosis, and the reaction amount between the sample and the reagent is increased. Also good. For the purpose of health check-up, the amount of reagent dispensed into the reaction container 21 is reduced, so that the ratio of the sample amount shown in the reaction solution is increased and the reaction amount between the specimen and the reagent is increased. In particular, if the sample dispensing volume is high enough to maintain the dispensing accuracy, there is no need to increase the sample dispensing volume in order to maintain the dispensing accuracy. The reaction amount of can be increased. In addition, when dispensing the diluted sample into the reaction container 21 after the sample has been diluted, the analyzer 1 for the purpose of health checkup uses the sample dilution rate for the purpose of health checkup as compared to the dilution rate for the purpose of general diagnosis. Alternatively, the reaction amount between the specimen and the reagent may be increased by setting the value lower. The analyzer 1 dilutes the sample after diluting the sample into the reaction container 21. When the sample is diluted for the purpose of the health diagnosis and the purpose of the general diagnosis, the same dilution ratio is used. May increase the reaction amount between the sample and the reagent by increasing the diluted sample dispensing amount or decreasing the reagent dispensing amount.

  Further, in the analyzer 1, in addition to increasing the reactivity between the sample and the reagent in the reaction solution, the detection conditions of the photometry unit 18 may be changed. In the analyzer 1, for example, in the case of general diagnostic purposes, considering that the absorbance greatly exceeds the value corresponding to the reference range, the absorbance measurement wavelength is shifted from the maximum absorption wavelength of the reaction solution, and the actual absorbance measurement value is obtained. May be suppressed. For this reason, in the analyzer 1, for the purpose of general diagnosis, the absorbance measurement wavelength is set to be shifted from the maximum absorption wavelength of the reaction solution. On the other hand, in the case of the health examination purpose, the analyzer 1 has a small amount of detection target contained in the sample and the actual absorbance is low, so that the absorbance measurement wavelength is set near the maximum absorption wavelength of the reaction solution. The absorbance measurement value is increased to reduce the influence of noise components and maintain analysis accuracy.

  When the amount of reaction between the sample and the reagent increases in proportion to the time, the analyzer 1 sets the reaction time or the observation time (photometric time) of the reaction more than the general diagnosis purpose for the purpose of the health diagnosis. The reaction amount may be increased by lengthening the reaction amount. In the analyzer 1, for example, as shown in the row R46 and the row R47 in the table T4 of FIG. 9, the measurement start point is 14 and the measurement end point is 27 for general diagnostic purposes. For the purpose of health check, the measurement start point is 14 and the measurement end point is 40, increasing the number of measurement points. As a result, in the case of the purpose of the health diagnosis, the analyzer 1 proceeds with the reaction between the specimen and the reagent by the amount of the measurement time longer than that for the purpose of the general diagnosis, and a lot of reactants are generated. The amount of change in absorbance in the liquid also increases, and an analysis result with little influence of noise components can be obtained.

  Moreover, in the analyzer 1, two or more of the analysis conditions are the sample dispensing amount, the sample dilution rate, the reagent dispensing amount, the photometric wavelength for the reaction solution, the reaction time in the reaction solution, and the measurement time for the reaction solution. It may be different depending on the purpose. For example, as shown in Table T5 of FIG. 10, in the analysis condition corresponding to the health diagnosis purpose, the sample amount shown in the row R51 is increased and the row R52 and the row R53 are compared with the analysis condition corresponding to the general diagnosis purpose. The amount of the reaction between the sample and the reagent may be increased by reducing the reagent dispensing amount shown in FIG.

  In the first embodiment, as illustrated in FIG. 3 and FIGS. 8 to 10, the analysis conditions are analyzed so that the analysis condition setting unit 32 can distinguish the analysis conditions for the general examination and the health examination. Although the case where the item names of the items are changed and stored in the storage unit 35 has been described, the analysis conditions for each of these analysis items can be added as needed for each purpose and stored in the storage unit 35. Further, as shown in FIG. 11, for the general diagnosis for holding each analysis condition for each analysis item corresponding to the general diagnosis purpose K1, for the health diagnosis category K1 for holding each analysis condition for each analysis item corresponding to the health diagnosis purpose. Each category K2 may be provided and stored as analysis condition information 36 in the storage unit 35. In this case, when the analysis condition setting unit 32 determines that the examination purpose is a health check, the analysis condition setting unit 32 may acquire the analysis condition corresponding to the analysis item instructed from the health check category K1, If it is determined that the inspection purpose is general diagnosis, an analysis condition corresponding to the analysis item instructed from the general diagnosis category K2 may be acquired.

  In the first embodiment, the general diagnosis and the health check have been described as examples of the inspection purpose. However, the present invention is not limited to this, and there are cases where, for example, the follow-up of the therapeutic effect is used for the inspection purpose. For example, a sample for the purpose of observing the therapeutic effect includes fewer detection objects than a sample for general diagnosis purposes, and includes more detection objects than a sample for health diagnosis purposes. Assuming that the analysis conditions are adjusted by adjusting the reaction amount between the sample and the reagent, the absorbance measurement wavelength, and the like. In this case, the analysis apparatus 1 changes the item names of the analysis items of each analysis condition so that the analysis conditions for general examination, medical examination and follow-up can be distinguished from each other, as shown in FIG. Apart from the health diagnosis category K1 and the general diagnosis category K2, a follow-up observation category K3 that holds the analysis conditions of each analysis item corresponding to the follow-up observation purpose may be provided.

(Embodiment 2)
Next, a second embodiment will be described. In the second embodiment, the analysis is performed for the analysis item for comparison that does not change the analysis result together with the analysis item for which the analysis is instructed, and the analysis is instructed based on the analysis result for the analysis item for comparison. Determine the reliability of the item analysis results.

  FIG. 12 is a schematic diagram illustrating the configuration of the analyzer according to the second embodiment. As shown in FIG. 12, in the analysis apparatus 201 according to the second embodiment, the control mechanism 203 includes a determination unit 232 together with the analysis condition setting unit 32 instead of the control unit 31 in the analysis apparatus 1 shown in FIG. A control unit 231 is provided.

  The determination unit 232 determines whether or not the analysis result of the analysis item instructed to be analyzed is normal. Here, when the analysis purpose is a health check purpose, the control unit 231 compares the analysis item with the analysis item instructed to be analyzed with the analysis result of the analysis item instructed to be analyzed. Analyzing process is executed at each part. When the analysis result in the analysis item for comparison is changed compared with the analysis result in the analysis item for comparison that has already been performed on the sample to be analyzed, the determination unit 232 is instructed to perform the analysis. It is determined that the analysis result of the item is an error, that is, the analysis result is not correct.

  Here, in the metabolic syndrome medical examination, AST, ALT, γ-GTP, HDL-Chol, LDL-Chol, Cre, Glu, HbA1c, UA and the like are examined as analysis items.

  The analysis items for comparison are items other than the analysis items in the metabolic syndrome medical examination, and are analysis items such as electrolytes Na, K, Cl, etc., in which the analysis results are less likely to vary within and between individuals. In this case, when the analysis result in the analysis item for comparison has changed compared with the analysis result in the comparison analysis item that has already been performed on the sample to be analyzed, the determination unit 232 determines whether the analysis target It is determined that a certain sample is abnormal, that is, there is a problem in handling such as pretreatment of the sample.

  Moreover, the analysis items for comparison are items other than the analysis items in the metabolic syndrome medical examination, and are analysis items such as IgA and IgM whose analysis results greatly vary among individuals. In this case, when the analysis result in the analysis item for comparison has changed compared with the analysis result in the comparison analysis item that has already been performed on the sample to be analyzed, the determination unit 232 determines whether the analysis target It is determined that there is a possibility that one sample is mistaken for another sample.

  Next, with reference to FIG. 13, it is a flowchart which shows the process sequence regarding the dispensing process in the analyzer 201. FIG. As shown in FIG. 13, the analysis condition setting unit 32 performs the analysis instruction information reception determination process (step S202) and receives the analysis instruction information until the analysis instruction information is received, similarly to step S2 shown in FIG. If it is determined that the determination has been made (step S202: Yes), analysis purpose determination processing is performed in the same manner as in step S4 shown in FIG. 2 (step S204).

  When the analysis condition setting unit 32 determines that the analysis purpose of the sample to be analyzed is the purpose of the health check (step S204: health check), the conditions for the health check are the same as in steps S6 and S8 shown in FIG. An acquisition process (step S206) and a condition setting process for health check (step S208) are performed. Then, the control unit 231 performs an analysis control process for controlling each part in the analyzer 1 according to the health diagnosis analysis conditions set by the analysis condition setting unit 32 to perform the analysis process (step S210). In this case, the control unit 231 compares the analysis items in which the analysis is instructed with the analysis results of the analysis item instructed to be analyzed, and the analysis items for comparison, for example, electrolytes Na, K, Cl, and IgA, are not changed. , IgM and other analysis items are analyzed for each part.

  Then, the control unit 231 receives the measurement result by the photometry unit 18 (step S212), and the analysis unit 34 analyzes the received analysis result and detects the concentration of the detection target in each analysis item (step S214). . In this case, the analysis unit 34 also analyzes analysis results for analysis items for comparison, for example, analysis items such as electrolytes Na, K, Cl, IgA, and IgM.

  Next, the determination unit 232 performs determination processing for determining whether the analysis result of the analysis item instructed to be analyzed is normal based on the analysis item for comparison analyzed by the analysis unit 34 (step S216). ). Then, the output unit 37 outputs the inspection result such as the concentration of the detection target detected by the analysis unit 34 in association with the determination result determined by the determination unit 232 (step S218).

  On the other hand, when the analysis condition setting unit 32 determines that the analysis purpose of the sample to be analyzed is the general diagnosis purpose (step S204: general diagnosis), the analysis condition is the same as in steps S26 to S36 shown in FIG. General diagnosis condition acquisition processing by the setting unit 32 (step S226), general diagnosis condition setting processing (step S228), analysis control processing by the control unit 231 (step S230), measurement result reception processing from the photometry unit 18 (step S232) ), Measurement result analysis processing by the analysis unit 34 (step S234), and analysis result output processing by the output unit 37 (step S236). And the control part 231 performs an analysis process completion | finish judgment process similarly to step S38 shown in FIG. 2 (step S238), and complete | finishes an analysis process.

  Next, the determination process shown in FIG. 13 will be described with reference to FIG. First, the determination unit 232 acquires a result of an electrolyte item such as Na, K, or Cl among the comparative analysis items (step S242). Further, the determination unit 232 acquires the result of the electrolyte item such as Na, K, Cl, etc., performed on the same specimen in the past from the storage unit 35, the external storage medium, or the external device (step S244).

  Then, the determination unit 232 compares the result of the electrolyte item performed this time with the result of the electrolyte item performed in the past, and compares the result of the electrolyte item performed this time with the result of the electrolyte item performed in the past. It is then determined whether there is a change (step S246).

  The electrolyte item value hardly changes within and between individuals in a specimen in which the amount of each substance is included only within a predetermined reference range, such as for health check purposes. That is, if the provider who provided the specimen is the same, the electrolyte item value hardly changes. Further, even when the providers who provide the specimens are different, the electrolyte item value hardly changes between the providers.

  For this reason, as shown in FIG. 15, the Na value in the second inspection is the value of Tn as indicated by a point P32, and the Na value in the third inspection carried out this time as indicated by a point P33a. If the value has greatly changed from the value Tn, it is considered that there is a problem in handling such as pretreatment of the specimen itself performed in the third examination. Therefore, when the determination unit 232 determines that there is a change in the result of the electrolyte item performed this time compared to the result of the electrolyte item performed in the past (step S246: Yes), the sample subjected to the current test It is determined that there is an abnormality, that is, there is a problem in handling the sample pretreatment or the like (step S248), and it is determined that the analysis result of this test is low in reliability.

  On the other hand, when the Na value in the third inspection performed this time was almost the same as the Na value Tn in the second inspection, as shown by a point P33b in FIG. 15, it was performed in the third inspection. It seems that the specimen was handled appropriately. Therefore, when the determination unit 232 determines that there is no change in the result of the electrolyte item performed this time compared to the result of the electrolyte item performed in the past (step S246: No), the sample subjected to the current test It is determined that there is no abnormality, that is, there is no problem in handling the specimen (step S250).

  Next, when the determination unit 232 determines in step S250 that there is no problem in handling the sample itself, the determination unit 232 acquires the results of the individual comparison items such as IgA and IgM among the comparative analysis items (step S250). S252). Further, the determination unit 232 acquires the result of the individual comparison items such as IgA and IgM performed on the same sample in the past from the storage unit 35, the external storage medium, the external device, or the like (step S254).

  Then, the determination unit 232 compares the result of the individual comparison item performed this time with the result of the individual comparison item performed in the past, and the result of the individual comparison item performed in the past has been performed in the past. It is determined whether or not there is a change in comparison with the result of the individual comparison item (step S256).

  Individual comparison item values such as IgA and IgM are larger among individuals in comparison with changes within individuals in the case where the amount of each substance is included only within a predetermined reference range, such as for health check purposes. Have a difference. That is, if the provider who provided the specimen is the same, the individual comparison item values such as IgA and IgM change little. On the other hand, when the provider who provided the sample is different, the individual comparison item value is greatly different.

  For this reason, as shown in FIG. 16, the IgA value in the second inspection is a value of Ti as shown at point P42, and the IgA value at the third time implemented this time as shown at point P43a is If the value Ti has changed significantly, it is considered that the specimen subjected to the third test is different from the specimen subjected to the second test. Therefore, when the determination unit 232 determines that the result of the individual comparison item performed this time is different from the result of the individual comparison item performed in the past (step S256: Yes), the current inspection is performed. It is determined that the sample that has been subjected to the test may be mistaken (step S258), and it is determined that the analysis result of the current test is low in reliability.

  On the other hand, as shown by a point P43b in FIG. 16, when the IgA value in the third inspection performed this time was almost the same as the IgA value Ti in the second inspection, it was performed in the third inspection. The sample is considered to be the same as the sample subjected to the second test. Therefore, when the determination unit 232 determines that there is no change in the result of the electrolyte item performed this time compared to the result of the electrolyte item performed in the past (step S256: No), the sample subjected to the current test (Step S260), it is determined that the analysis result of this test is highly reliable because the sample is handled properly and the sample is not mistaken.

  Then, the determination unit 232 outputs the determination results made in steps S248, S250, S258, and S260 (step S262). Since the output unit 37 outputs the determination result performed by the determination unit 232 in association with the analysis result, the operator of the analysis apparatus 201 recognizes the presence or absence of reliability in the analysis result by referring to the determination result. can do.

  As described above, according to the second embodiment, the analysis items instructed to be analyzed, the electrolyte items such as Na, K, and Cl and the individual comparison items such as IgA and IgM are analyzed, and the electrolyte items and the individual comparison items are analyzed. Since it is determined whether or not the analysis result of the analysis item instructed to be analyzed is appropriate based on the change in the analysis result of the item, the reliability of the analysis result can be further increased.

  Note that the analyzers 1 and 201 according to the first and second embodiments may be applied to an analysis system connected to an external device via a network. For example, as shown in FIG. 17, such an analysis system includes a plurality of analysis devices 1 and a management server 41 that is connected to each analysis device 1 via a network N and manages each analysis device 1. The management server 41 has a database 42 that stores various types of information. Each analysis device 1 transmits the analysis result of the analysis unit 34 to the management server 41 via the network N, and the management server 41 stores the transmitted analysis result in the database 42.

  Here, the management server 41, when the provider who provided the specimen has undergone a health check regularly, the test result of each health check and the sex, age, lifestyle pattern, family history of the provider Based on the above, the risk rate of the abnormality of the provider's body may be calculated statistically and output before the next medical checkup. In the analyzer 1, a slight change in the test value within the reference range of the healthy subject and in the vicinity of the reference range is accurately detected using the analysis conditions corresponding to the purpose of the health check for the sample for the purpose of the health check. Can be determined. For this reason, it is considered that the reliability of the calculated risk factor is increased by using the inspection result analyzed by the analyzer 1.

  In the analysis system shown in FIG. 17, the management server 41 automatically determines the health condition of the sample provider using a predetermined determination criterion based on the analysis result in the analysis apparatus 1, and the determination result and instruction content May be output. In the analyzer 1, a slight change in the test value within the reference range of the healthy subject and in the vicinity of the reference range is accurately detected using the analysis conditions corresponding to the purpose of the health check for the sample for the purpose of the health check. Can be determined. For this reason, it is considered that the reliability of the output determination result is enhanced by using the inspection result analyzed by the analyzer 1.

  In addition, the management server 41 shown in FIG. 17 uses the standard for each health check result in each health check result even when a health check or the like is performed at different facilities, that is, different analyzers 1 for the same sample provider. You may acquire the test result which suppressed the influence by the difference between several facilities by taking into consideration the difference in value. In the analyzer 1, a test result that is less affected by dispensing components and noise components in the measurement value can be obtained by using the analysis conditions corresponding to the health diagnosis purpose for the sample that is the purpose of the health diagnosis. For this reason, it is considered that the difference in analysis accuracy between the analyzers 1 is also small, and the difference between the plurality of analyzers with respect to the inspection result is also small. Therefore, by adding the difference in the reference value at each facility to each health check result by each analyzer 1, it is possible to obtain a test result that further suppresses the influence due to the difference between the facilities.

  In the first and second embodiments, the case where an optically readable recording medium is attached to the sample container 13a has been described as an example. However, the present invention is not limited to this, and information is transmitted via radio waves of a predetermined frequency. An RFID (Radio Frequency Identification) tag that can be read and written may be attached to the sample container 13a. This RFID tag includes sample information such as information on the provider who provided the sample, analysis items to be performed on the sample stored in the sample container 13a, and information on the analysis purpose of the sample stored in the sample container 13a. The sample reading unit 13c reads and reads the sample information written on the RFID tag by transmitting and receiving radio waves of a predetermined frequency to and from the RFID tag attached to the sample container 13a. Information may be input to the control units 31 and 231. The sample container 13a may be provided with both an optically readable information medium and an RFID tag. In this case, the sample reading unit 13c may read information on the information medium and the RFID tag attached to the sample container 13a by transmitting and receiving radio waves of a predetermined wavelength in addition to emitting infrared light or visible light.

  In the first and second embodiments, the case where the analysis purpose for the sample is included in the sample information read by the sample reading unit 13c has been described as an example. 33 may be input from the external device via the transmission / reception unit 38.

  In addition, when the analyzers 1 and 201 according to the first and second embodiments are used, “general diagnosis purpose” or “health diagnosis purpose” is included in an inspection slip for selecting an analysis item to be performed on a sample in operation. Is provided with a selection field for selecting an analysis purpose, and based on the examination slip, the operator of the analyzers 1, 201 discriminates the analysis purpose of the sample to be analyzed, and the analyzers 1, 201 In addition, information regarding the analysis purpose may be input via the input unit 33. In addition, for example, when collecting a sample from a provider, the color or label color of the sample storage container that stores the sample is changed to “General diagnosis purpose” or “Health diagnosis purpose” to prevent errors in the analysis purpose at the time of sample collection. May be.

  The analysis devices 1 and 201 described in the above embodiment can be realized by executing a program prepared in advance by a computer system. This computer system implements the processing operation of the analyzer by reading and executing a program recorded on a predetermined recording medium. Here, the predetermined recording medium is not limited to “portable physical medium” such as a flexible disk (FD), a CD-ROM, an MO disk, a DVD disk, a magneto-optical disk, and an IC card, but also inside and outside the computer system. It includes any recording medium that records a program readable by a computer system, such as a “communication medium” that holds the program in a short time when transmitting the program, such as a hard disk drive (HDD) provided. In addition, this computer system obtains a program from a management server or another computer system connected via a network line, and executes the obtained program to realize the processing operation of the analyzer.

1 is a schematic diagram illustrating a configuration of an analyzer according to a first embodiment. It is a flowchart which shows the process sequence regarding the analysis process in the analyzer shown in FIG. It is a figure which illustrates the analysis conditions in the analysis item AST in the analyzer shown in FIG. It is a figure which illustrates the analysis conditions in the analysis item AST when using a high concentration reagent in the analyzer shown in FIG. It is a figure explaining the analysis possible range in the analyzer shown in FIG. It is a figure explaining the analysis possible range in the analyzer shown in FIG. It is a figure which illustrates the analysis result list which the analyzer shown in FIG. 1 outputs. It is a figure which illustrates the analysis conditions in the analysis item AST in the analyzer shown in FIG. It is a figure which illustrates the analysis conditions in the analysis item AST in the analyzer shown in FIG. It is a figure which illustrates the analysis conditions in the analysis item AST in the analyzer shown in FIG. It is a figure which illustrates the storage state of each information memorize | stored in the memory | storage part shown in FIG. FIG. 3 is a schematic diagram illustrating a configuration of an analyzer according to a second embodiment. It is a flowchart which shows the process sequence regarding the analysis process in the analyzer shown in FIG. It is a flowchart which shows the process sequence of the determination process shown in FIG. It is a figure explaining the determination process shown in FIG. It is a figure explaining the determination process shown in FIG. It is a schematic diagram which shows the structure of the analysis system which has an analyzer shown in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1,201 Analyzer 2 Measuring mechanism 3,203 Control mechanism 10 Reaction table 11 1st reagent storage 11a 1st reagent container 11b 1st reagent reading part 12 1st reagent dispensing mechanism 13 Sample transfer part 13a Sample container 13b Sample rack 13c Sample reading unit 14 Sample dispensing mechanism 12a, 14a, 16a Arm 15 Second reagent storage 15a Second reagent container 15b Second reagent reading unit 16 Second reagent dispensing mechanism 17 Stirring unit 18 Photometric unit 19 Washing unit 21 Reaction vessel 31 , 231 Control unit 32 Analysis condition setting unit 33 Input unit 34 Analysis unit 35 Storage unit 36 Analysis condition information 37 Output unit 38 Transmission / reception unit 232 Determination unit

Claims (9)

In an analyzer that dispenses a reagent according to an analysis item to a sample dispensed in a reaction container and analyzes the sample based on the optical characteristics of the reaction solution of the sample and the reagent,
An analysis apparatus characterized in that an analysis process is performed for each analysis item under an analysis condition according to an analysis purpose. Storage means for storing analysis conditions according to each analysis purpose for each analysis item;
Setting means for acquiring from the storage means the analysis conditions according to the analysis purpose of the sample to be analyzed for each analysis item, and setting the acquired analysis conditions as analysis conditions for the sample to be analyzed;
Control means for controlling each part in the analyzer according to the analysis conditions set for each analysis item by the setting means;
The analyzer according to claim 1, further comprising: An input means for inputting the analysis purpose of the sample to be analyzed;
The setting means acquires from the storage means an analysis condition according to the analysis purpose of the sample that is the analysis target input by the input means, and sets the acquired analysis condition as the analysis condition that is the analysis target. The analyzer according to claim 2.   The analysis apparatus according to claim 1, wherein the analysis purpose is a health diagnosis purpose or a general diagnosis purpose. Further comprising photometric means for measuring the optical properties of the reaction solution,
The analysis conditions corresponding to the health diagnosis purpose are conditions for increasing the reaction amount between the sample and the reagent and / or conditions for increasing the photometric sensitivity of the photometric means over the analysis conditions corresponding to the general diagnosis purpose. The measurement range of the optical characteristics by the photometric means is narrower than the measurement range in the analysis conditions corresponding to the general diagnostic purpose, and is in the vicinity of the reference range including the reference range indicating that it is healthy. The analyzer according to claim 4, wherein the analyzer is provided.   The analysis conditions are as follows: sample dispensing amount, sample dilution rate, reagent dispensing amount, reagent concentration, reagent dilution rate, photometric wavelength for the reaction solution, reaction time in the reaction solution, and measurement for the reaction solution. 6. The analysis apparatus according to claim 1, wherein at least one of the times is different depending on each analysis purpose. A determination means for determining whether or not the analysis result in the analysis item instructed to perform the analysis is normal;
When the analysis purpose is the health examination purpose, the control means compares the analysis item with the analysis item instructed to analyze the analysis result for comparison with which the analysis result does not change For each part to perform the analysis process for
The determination means performs the analysis if the analysis result in the comparative analysis item has changed in comparison with the analysis result in the comparative analysis item that has already been performed on the sample to be analyzed. The analysis apparatus according to claim 2, wherein the analysis result of the instructed analysis item is determined to be abnormal. The analysis items for comparison are analysis items whose analysis results have little variation within and between individuals,
If the analysis result in the comparison analysis item has changed compared to the analysis result in the comparison analysis item that has already been performed on the sample to be analyzed, the determination means The analyzer according to claim 7, wherein it is determined that the sample is abnormal. The above analysis items for comparison are analysis items whose analysis results vary greatly between individuals,
If the analysis result in the comparison analysis item has changed compared to the analysis result in the comparison analysis item that has already been performed on the sample to be analyzed, the determination means The analysis apparatus according to claim 7, wherein it is determined that there is a possibility that the sample that is is mistaken for another sample.

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