JP2008195719A - Inhibitor for blood sugar elevation - Google Patents

Inhibitor for blood sugar elevation Download PDF

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JP2008195719A
JP2008195719A JP2008033747A JP2008033747A JP2008195719A JP 2008195719 A JP2008195719 A JP 2008195719A JP 2008033747 A JP2008033747 A JP 2008033747A JP 2008033747 A JP2008033747 A JP 2008033747A JP 2008195719 A JP2008195719 A JP 2008195719A
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composition
subfamily
food
increase
sakura
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Kazuyoshi Yazawa
一良 矢澤
Tomoyuki Susa
智之 諏佐
Yoshiyuki Shirosaki
美幸 城▲崎▼
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Shonan Inst For Medical & Prev
Shonan Institute for Medical and Preventive Science
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Shonan Institute for Medical and Preventive Science
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Abstract

<P>PROBLEM TO BE SOLVED: To obtain a composition having an inhibitory action against increase in blood glucose level, in its turn, a food and beverage, quasi-drug or medicine comprising the composition. <P>SOLUTION: The composition for inhibiting blood sugar elevation comprises a component of a plant of the subfamily Prunoideae (Prunus persica Batsch, Prunus armeniaca or Prunus salicina). The food and beverage, the quasi-drug or the medicine comprises the composition. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

本発明は血糖値上昇抑制を目的とした組成物、及び該組成物を含む飲食品又は医薬部外品、医薬品に関する。  The present invention relates to a composition for the purpose of suppressing an increase in blood glucose level, and a food or drink or quasi-drug containing the composition, or a pharmaceutical product.

血糖値上昇を抑制する飲食品、医薬品は糖尿病、肥満の予防、治療に有用である。また、ダイエットのカロリーコントロールにも利用されている。現在、血糖値上昇抑制剤として桑の葉、グァバ葉ポリフェノール、豆鼓エキス、ボグリボースなどが知られているが、より効果の高い新しい素材が求められている。  Foods and beverages and pharmaceuticals that suppress an increase in blood glucose level are useful for the prevention and treatment of diabetes and obesity. It is also used for diet calorie control. Currently, mulberry leaves, guava polyphenols, bean drum extract, voglibose, and the like are known as blood sugar level increase inhibitors, but new materials with higher effects are demanded.

サクラ亜科（学名：Ｐｒｕｎｏｉｄｅａｅ）とはバラ科の下位分類の一つでサクラ、ウメ、モモなど日本で古くから親しまれている花木類である。ウメ、モモ、アンズ、スモモは果肉が食用されている。モモ（学名：Ｐｒｕｎｕｓ ｐｅｒｓｉｃａ Ｂａｔｓｃｈ又はＰｒｕｎｕｓ ｐｅｒｓｉｃａ Ｂａｔｓｃｈ ｖａｒ Ｄａｖｉｄｉａｎａ Ｍａｘｉｍ．）は中国原産とされるバラ科・サクラ亜科の落葉小高木である。アンズ（学名：Ｐｒｕｎｕｓ ａｒｍｅｎｉａｃａ）は中国北部原産とされるバラ科・サクラ亜科の落葉小高木である。スモモ（別名プラム、プルーン）、（学名：Ｐｒｕｎｕｓ ｓａｌｉｃｉｎａ）は中国原産とされるバラ科・サクラ亜科の落葉小高木である。ウメ（学名：Ｐｒｕｎｕｓ ｍｕｍｅ）は中国の長江流域原産とされる落葉高木である。梅の葉部の血糖値上昇抑制作用が報告されているが、有意な血糖値上昇抑制作用はない。また、細胞を用いた研究により、モモの果肉部にインスリン感受性の上昇作用があり糖尿病予防の可能性があることが報告されているが、本発明とはメカニズムが異なり、糖類の消化酵素阻害・吸収阻害による血糖値上昇抑制作用ではない。本発明は単回の摂取で効果のある糖質の消化酵素阻害・吸収阻害による血糖値上昇抑制組成物である。また、腸管内で起こる糖質の消化酵素阻害・吸収阻害による血糖値上昇抑制作用はインスリン感受性の上昇作用等、細胞内で起こる血糖値降下作用よりも安全性が高く、効果が明確なことから糖尿病治療の第１選択薬として使用されている．本発明以前の時点で、モモが糖質の消化酵素阻害・吸収阻害により血糖値上昇を抑制するという報告はまったく無い。また、モモの果肉以外の成分が糖尿病の予防、改善やダイエットなどに有用であることは全く知られていなかった。
特開２００４−１１５５４２号公報 農産物の生活習慣予防作用に関する研究（第１報）モモ、リンゴ、プラム、ブドウ（巨峰）、アンズ抽出物による糖・脂質代謝の活性化とインスリン感受性の上昇、深井洋一、松沢恒友、関谷敬三、日本食品科学工学会誌、Ｖｏｌ４７、Ｎｏ．２、Ｐａｇｅ９２−９６、２０００ Sakura subfamily (scientific name: Prunoideae) is one of the subclasses of the Rosaceae family, and is a flower tree that has been popular in Japan for a long time, such as cherry, plum, and peach. Plums, peaches, apricots and plums are edible. Peach (scientific name: Prunus persica Batsch or Prunus persica Batsch var Davidiana Maxim.) Is a small deciduous tree of the family Rosaceae and Prunus subfamily that is native to China. Apricot (Prunus armenica) is a small deciduous tree of the Rosaceae family and the Sakura family belonging to northern China. Plum (also known as plum, prune), (scientific name: Prunus salicina) is a deciduous small tree of the Rosaceae / Chrysantaceae family that is native to China. Ume (scientific name: Prunus mume) is a deciduous tree that is native to the Yangtze River basin in China. Although it has been reported to suppress the increase in blood glucose level in the leaves of plum, it does not have a significant increase in blood glucose level. In addition, research using cells has reported that the peach pulp has an insulin-sensitizing effect and has the potential to prevent diabetes, but the mechanism is different from the present invention. It is not an action to suppress an increase in blood glucose level by inhibiting absorption. The present invention is a composition for suppressing an increase in blood glucose level by digestive enzyme inhibition / absorption inhibition of carbohydrates that is effective by a single intake. In addition, the inhibitory action on the increase in blood glucose level due to the inhibition of digestive enzymes and absorption of carbohydrates occurring in the intestinal tract is safer and clearer than the action to lower the blood sugar level occurring in the cells, such as an increase in insulin sensitivity. It is used as a first-line drug for the treatment of diabetes. Prior to the present invention, there has been no report that peach suppresses an increase in blood glucose level by inhibiting digestive enzymes and absorption of carbohydrates. In addition, it has not been known at all that ingredients other than peach pulp are useful for the prevention, improvement and diet of diabetes.
JP 2004-115542 A Studies on preventive effects of agricultural products on lifestyle habits (Part 1) Peach, apple, plum, grape (Kyoho), activation of sugar and lipid metabolism and increased insulin sensitivity by apricot extract, Yoichi Fukai, Tsuneto Matsuzawa, Keizo Sekiya, Journal of Japan Society for Food Science and Technology, Vol 47, No. 2, Pages 92-96, 2000

本発明は、効果が高く、単回の摂取で効果があり、安全性の高い糖質の消化酵素阻害・吸収阻害による血糖値上昇抑制作用を有する組成物を提供し、ひいては該組成物を含有する飲食品又は医薬部外品、医薬品を提供することにある。  The present invention provides a composition that is highly effective, effective in a single ingestion, and has a high level of safety by inhibiting the digestive enzyme inhibition and absorption of carbohydrates, and thus contains the composition. It is to provide food and drink or quasi-drugs and pharmaceuticals.

上記の課題を解決するために鋭意検討を重ねた結果、サクラ亜科の植物（モモ、アンズ、スモモ）に顕著な血糖値上昇抑制作用があることを見出した。すなわち本発明は、以下の構成を有する。
（１）サクラ亜科の植物（モモ、アンズ、スモモ）が糖質の消化酵素阻害・吸収阻害作用を有することを特徴とする血糖値上昇抑制組成物。
（２）上記（１）に記載の組成物を含有する飲食品又は医薬部外品、医薬品。As a result of intensive studies in order to solve the above-mentioned problems, it was found that plants of the cherry subfamily (peaches, apricots, plums) have a remarkable blood glucose level inhibitory action. That is, the present invention has the following configuration.
(1) A composition for suppressing an increase in blood glucose level, wherein plants (peaches, apricots, plums) of the subfamily Sakura have an action of inhibiting digestive enzymes and absorption of carbohydrates.
(2) Food / beverage products or quasi-drugs and pharmaceuticals containing the composition according to (1) above.

本発明により、糖質の消化酵素阻害・吸収阻害作用を有するサクラ亜科の植物の成分を含有することを特徴とする血糖値上昇抑制組成物、及び該組成物を含有する飲食品又は医薬部外品、医薬品を提供することができる。  According to the present invention, a composition for suppressing an increase in blood glucose level, comprising a component of a plant belonging to the subfamily Sakura, which has an action of inhibiting digestive enzymes and absorption of carbohydrates, and a food or drink or pharmaceutical part containing the composition We can provide foreign products and medicines.

本発明に関わるサクラ亜科とは学名：Ｐｒｕｎｏｉｄｅａｅをさす。モモとは学名：Ｐｒｕｎｕｓ ｐｅｒｓｉｃａ Ｂａｔｓｃｈ又はＰｒｕｎｕｓ ｐｅｒｓｉｃａ Ｂａｔｓｃｈ ｖａｒ Ｄａｖｉｄｉａｎａ Ｍａｘｉｍ．、アンズとは学名：Ｐｒｕｎｕｓ ａｒｍｅｎｉａｃａ、スモモとは学名：Ｐｒｕｎｕｓ ｓａｌｉｃｉｎａをさす。  The Sakura subfamily related to the present invention refers to the scientific name: Prunoideae. Peach is scientific name: Prunus persica Batsch or Prunus persica Batsch var Davidiana Maxim. The apricot is the scientific name: Prunus armenica, and the plum is the scientific name: Prunus salicina.

本発明に関わるサクラ亜科植物は、植物全体、又は葉部をそのまま用いてもよく、これらを乾燥した乾燥体、もしくは乾燥後粉砕した粉末を用いることもできる。また、これらを水抽出、熱水抽出、酸性下での抽出、アルカリ性下での抽出、エタノール、アセトン、酢酸エチル、ヘキサン等有機溶媒で抽出した抽出物を用いることもできる。  The cherry subfamily related to the present invention may use the whole plant or the leaf part as it is, and a dried product obtained by drying these or a powder obtained by pulverizing after drying can also be used. Moreover, the extract which extracted these with water, hot water extraction, the extraction under an acid, the extraction under an alkali, and organic solvents, such as ethanol, acetone, ethyl acetate, hexane, can also be used.

本発明に関わる血糖値上昇抑制剤を製造するには、上記の方法で製造したサクラ亜科植物の成分を用いることができ、常法に従って公知の医薬用無毒性担体と組み合わせて製剤化すればよい。本発明に関わる血糖値上昇抑制剤は、種々の剤型での投与が可能であり、例えば、経口投与剤としては錠剤、顆粒剤、散剤、カプセル剤、ソフトカプセル剤などの固形剤、溶液剤、懸濁剤、乳化剤等の液剤、凍結乾燥剤等があげられ、これらの製剤は製剤上の常套手段により調製することができる。上記医薬用無毒性担体としては、例えば、グルコース、乳糖、ショ糖、でんぷん、マンニトール、デキストリン、脂肪酸グリセリド、ポリエチレングリコール、ヒドロキシエチルでんぷん、エチレングリコール、ポリオキシエチレンソルビタン脂肪酸エステル、アミノ酸、アルブミン、水、生理食塩水などが挙げられる。また、必要に応じて安定化剤、滑沢剤、湿潤剤、乳化剤、結合剤等の慣用の添加剤を適宜添加することができる。本発明に関わる血糖値上昇抑制剤において、サクラ亜科植物の成分の投与量は、患者の年齢、体重、症状、疾患の程度、投与スケジュール、製剤形態等により、適宜選択、決定されるが、例えば、一日当たり生葉等価量として０．０１−１００ｇ／ｋｇ体重程度とされ、一日数回に分けて投与してもよい。  In order to produce a blood sugar level increase inhibitor according to the present invention, the components of the cherry subfamily plant produced by the above method can be used, and if formulated in combination with a known non-toxic pharmaceutical carrier according to a conventional method Good. The blood glucose level elevation inhibitor according to the present invention can be administered in various dosage forms. For example, as an oral administration agent, a solid agent such as a tablet, a granule, a powder, a capsule, a soft capsule, a solution, Suspensions, liquids such as emulsifiers, freeze-drying agents and the like can be mentioned, and these preparations can be prepared by conventional means in preparation. Examples of the non-toxic pharmaceutical carrier include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, albumin, water, Examples thereof include physiological saline. In addition, conventional additives such as stabilizers, lubricants, wetting agents, emulsifiers, binders and the like can be appropriately added as necessary. In the blood glucose level elevation inhibitor according to the present invention, the dosage of the components of the cherry subfamily plant is appropriately selected and determined according to the patient's age, body weight, symptoms, degree of disease, administration schedule, formulation form, etc. For example, the equivalent amount of fresh leaves per day is about 0.01-100 g / kg body weight, and may be administered in several divided doses per day.

また、本発明に関わるサクラ亜科植物は、毒性を有することは報告されていないことから、血糖値上昇抑制を目的とした飲食品として摂取することもできる。本発明に関わるサクラ亜科植物の成分は、特定保健用食品、栄養機能食品、又は健康食品等として位置付けることができる。機能性食品としては、例えば、サクラ亜科植物の成分に適当な助剤を添加した後、慣用の手段を用いて、食用に適した状態、例えば、顆粒状、粒状、錠剤、カプセル剤、ソフトカプセル剤、ペースト状等に形成したものを用いることができる。この飲食品は、そのまま食用に供してもよく、また種々の食品（例えばハム、ソーセージ、かまぼこ、ちくわ、パン、バター、粉乳、菓子など）に添加して使用したり、水、酒類、果汁、牛乳、清涼飲料水等の飲物に添加して使用してもよい。かかる食品の形態における本発明のサクラ亜科植物の成分の摂取量は、年齢、体重、症状、疾患の程度、食品の形態等により適宜選択・決定されるが、例えば、一日当たり生葉等価量として０．０１−１００ｇ／ｋｇ体重程度とされ、一日数回に分けて投与してもよい。  In addition, since the cherry subfamily related to the present invention has not been reported to be toxic, it can be taken as a food or drink for the purpose of suppressing an increase in blood glucose level. The components of the cherry subfamily related to the present invention can be positioned as food for specified health use, nutritional functional food, health food or the like. As functional foods, for example, after adding a suitable auxiliary agent to the components of the cherry subfamily, and using conventional means, it is in an edible state, for example, granular, granular, tablet, capsule, soft capsule What was formed in the agent, the paste form, etc. can be used. This food and drink may be used for food as it is, and added to various foods (for example, ham, sausage, kamaboko, chikuwa, bread, butter, powdered milk, confectionery, etc.), water, alcoholic beverages, fruit juice, You may add and use for drinks, such as milk and a soft drink. The intake amount of the components of the subfamily of the present invention in the form of such food is appropriately selected and determined according to age, weight, symptoms, degree of disease, form of food, etc. The dose may be about 0.01-100 g / kg body weight, and may be administered in several divided doses per day.

以下に本発明をより詳細に説明するために実施例を挙げるが、本発明はこれらによって何ら限定されるものではない。  Examples are given below to describe the present invention in more detail, but the present invention is not limited by these.

［実施例１］サクラ亜科植物の抽出物の調製
被験試料としてサクラ亜科の植物の葉のメタノール抽出物を用いた。サクラ亜科の植物の葉の粗切物を１０倍量のメタノールに浸漬し、減圧乾固して抽出物を得た。
［実施例２］サクラ亜科植物（葉）メタノール抽出物の血糖値上昇抑制作用
６〜７週齢の雄ｄｄＹマウス（ｎ＝８）を実験前日から２４時間絶食後、実験前に各群の平均体重が均等になるように群分けをした。糖負荷試験に用いるための溶性デンプン、マルトース、グルコースは１，０００ｍｇ／Ｋｇを、スクロースは２，０００ｍｇ／Ｋｇを１ｍｌの蒸留水に溶解させた。サンプル投与群では、各々の糖とサンプル（１，０００ｍｇ／Ｋｇ）を混合して１ｍｌの蒸留水に溶解させ、ゾンデを用いてマウスの胃内へ直接経口投与した。採血は経口投与後、０（経口投与前）、３０、６０、９０、１２０分時にマウスの尾部より行い、抗凝固剤を添加したマイクロチューブに血液を採血し、採血した血液サンプルは直ぐに１０，０００ｒｐｍで約２分間遠心し、血漿を２μｌとり、９６ウェルプレートに分注し、これを測定試料とした。血漿中のグルコース濃度測定にはグルコースＣＩＩテストワコー（ムタローゼ・ＧＯＤ法）（和光純薬）を使用し、４９２ｎｍで吸光度を測定し、検量線から血糖値を求めた。投与後、血糖値の上昇値のピークは３０分後であることから、糖負荷３０分後の血糖値をコントロール群と比較した。結果の値は平均±標準誤差で表した。各群間の有意差はＳｔｕｄｅｎｔ’ｓ ｔ−ｔｅｓｔによって評価し、ｐ＜０．０５を統計的に有意であるとした。その結果を表１に示した。[Example 1] Preparation of extract of cherry subfamily plants Methanol extract of leaves of the cherry family plants was used as a test sample. A rough cut of a leaf of the subfamily Sakura was immersed in 10 times the amount of methanol and dried under reduced pressure to obtain an extract.
[Example 2] Inhibition of blood glucose level increase by Sakura subfamily plant (leaf) methanol extract 6-7 weeks old male ddY mice (n = 8) were fasted for 24 hours from the day before the experiment, before each experiment. The groups were divided so that the average body weight was equal. Soluble starch, maltose and glucose for use in the sugar tolerance test were dissolved in 1,000 mg / Kg, and sucrose was dissolved in 1 ml of distilled water. In the sample administration group, each saccharide and sample (1,000 mg / Kg) were mixed and dissolved in 1 ml of distilled water, and orally administered directly into the stomach of a mouse using a sonde. Blood was collected from the tail of the mouse at 0 (before oral administration), 30, 60, 90, and 120 minutes after oral administration, and blood was collected in a microtube to which an anticoagulant was added. Centrifugation was performed at 000 rpm for about 2 minutes, and 2 μl of plasma was taken and dispensed into a 96-well plate, which was used as a measurement sample. Glucose CII test Wako (Mutarose GOD method) (Wako Pure Chemical Industries, Ltd.) was used for measuring the glucose concentration in plasma, the absorbance was measured at 492 nm, and the blood glucose level was determined from the calibration curve. Since the peak of the blood sugar level increased 30 minutes later after administration, the blood sugar level 30 minutes after the glucose load was compared with the control group. The result value was expressed as mean ± standard error. Significant differences between groups were assessed by Student's t-test, with p <0.05 considered statistically significant. The results are shown in Table 1.

Figure 2008195719
この結果より、サクラ亜科植物（モモ、アンズ、スモモ）の葉の抽出物は溶性デンプン、スクロース、マルトース、グルコース等の糖質摂取による血糖値の上昇を有意に抑制することが示された。
Figure 2008195719
 From this result, it was shown that the leaf extract of the cherry subfamily (peach, apricot, plum) significantly suppresses the increase in blood sugar level due to the intake of carbohydrates such as soluble starch, sucrose, maltose and glucose.

上記の結果を受けて最も活性の強かったモモについて予想される血糖値上昇抑制作用のメカニズムの一つとして、糖質消化酵素の阻害活性を測定した。
［実施例３］サクラ亜科植物メタノール抽出物の糖質酵素阻害活性試験
α−アミラーゼ阻害活性試験はＸｉａｏらの方法を改良して行った。２ｍＭ ＣａＣｌ２と０．２％ウシ血清アルブミン含有０．１Ｍ酢酸Ｂｕｆｆｅｒ（ｐＨ６．９），基質として２．５ｍｇ／ｍｌの溶性デンプン溶液，酵素として０．２ｕｎｉｔｓの豚膵臓由来α−アミラーゼ（ＥＣ ３．２．１．１），呈色液にヨウ素溶液を用い，一定時間の反応ののち分解されずに残存したデンプンをヨウ素デンプン反応で評価した。α−アミラーゼ阻害活性はサンプルを含有していないコントロールと比較して表した。マルターゼ阻害活性，スクラーゼ阻害活性はマルトースとスクロースを基質としてＤａｈｌｑｖｉｓｔ，Ａらの方法を改良して行った。２ｍＭ ＣａＣｌ２含有０．１Ｍリン酸Ｂｕｆｆｅｒ，基質として８３ｍＭマルトースと１６６ｍＭスクロース，酵素としてマウスの小腸上皮から回収したα−グルコシダーゼ粗酵素液（マルターゼ，スクラーゼを含む）を用い，一定時間の反応により生成されたグルコースをグルコースＣＩＩテストワコーキットを用いて，吸光度４９２ｎｍで測定し，検量線からグルコース量を算出した。マルターゼ，スクラーゼ阻害活性はサンプルを含有していないコントロールと比較して表した。結果を表２に示した。Based on the above results, the inhibitory activity of carbohydrate digestive enzymes was measured as one of the mechanisms of the anti-blood glucose level-suppressing action expected for the peach having the strongest activity.
[Example 3] Glucose enzyme inhibitory activity test of Sakura subfamily methanol extract The α-amylase inhibitory activity test was carried out by improving the method of Xiao et al. 0.1 M acetate buffer (pH 6.9) containing 2 mM CaCl 2 and 0.2% bovine serum albumin, a soluble starch solution of 2.5 mg / ml as a substrate, and 0.2 units of porcine pancreatic α-amylase (EC 3) as an enzyme 2.1.1.1), an iodine solution was used as the coloring solution, and the starch remaining without being decomposed after the reaction for a certain time was evaluated by the iodine starch reaction. α-Amylase inhibitory activity was expressed relative to a control containing no sample. Maltase inhibitory activity and sucrase inhibitory activity were carried out by improving the method of Dahlqvist, A et al. Using maltose and sucrose as substrates. Produced by reaction for a certain period of time using 0.1 M phosphate buffer containing 2 mM CaCl 2 , 83 mM maltose and 166 mM sucrose as substrates, and α-glucosidase crude enzyme solution (including maltase and sucrase) collected from mouse small intestinal epithelium as enzyme The glucose was measured at an absorbance of 492 nm using a glucose CII test Wako kit, and the amount of glucose was calculated from a calibration curve. The maltase and sucrase inhibitory activity was expressed in comparison with a control containing no sample. The results are shown in Table 2.

Figure 2008195719
この結果より、少なくともサクラ亜科植物の葉の抽出物は糖質消化酵素としてα−アミラーゼ，マルターゼ，スクラーゼ活性を濃度依存的に阻害することが示された。
Figure 2008195719
 From this result, it was shown that at least a leaf extract of the cherry subfamily plant inhibits α-amylase, maltase and sucrase activities as a carbohydrate digestive enzyme in a concentration-dependent manner.

本発明により、糖質の消化酵素阻害作用・吸収阻害を有するサクラ亜科（モモ、アンズ、スモモ）植物の成分を含有することを特徴とする血糖値上昇抑制組成物及び該組成物を含有する飲食品又は医薬部外品、医薬品提供することが可能となった。  According to the present invention, a composition for suppressing an increase in blood glucose level, comprising a component of a cherry subfamily (peach, apricot, plum) having a carbohydrate digestive enzyme inhibitory action / absorption inhibition, and the composition are contained. It became possible to provide food and drink, quasi-drugs, and pharmaceuticals.

Claims (10)

サクラ亜科の植物（ウメ以外のモモ、アンズ、スモモ）が糖類の消化酵素阻害作用・吸収阻害を有することを特徴とする血糖値上昇抑制組成物。A composition for suppressing an increase in blood glucose level, wherein plants of the subfamily Sakura (peaches other than plums, apricots, plums) have a sugar digestive enzyme inhibitory action / absorption inhibitory action. 請求項１の組成物がサクラ亜科の植物（ウメ以外のモモ、アンズ、スモモ）が果肉以外の部位からなることを特徴とする血糖値上昇抑制組成物。A composition for suppressing blood sugar level increase, wherein the composition of the subfamily Sakura (Peach other than plum, peach, apricot, plum) is composed of a part other than pulp. 請求項１または２に記載の組成物を含有する飲食品又は、医薬部外品、医薬品。A food or drink, a quasi-drug, or a pharmaceutical comprising the composition according to claim 1 or 2. 請求項１または２に記載のサクラ亜科の植物がモモであることを特徴とする血糖値上昇抑制組成物。A composition for suppressing an increase in blood glucose level, wherein the plant of the subfamily Sakura family according to claim 1 or 2 is a peach. 請求項４に記載の組成物を含有する飲食品又は、医薬部外品、医薬品。A food or drink, a quasi-drug, or a pharmaceutical comprising the composition according to claim 4. 請求項１または２に記載のサクラ亜科の植物がアンズであることを特徴とする血糖値上昇抑制組成物。A composition for suppressing an increase in blood glucose level, wherein the plant of the subfamily Sakura of claim 1 or 2 is apricot. 請求項６に記載の組成物を含有する飲食品又は、医薬部外品、医薬品。A food or drink, a quasi-drug, or a pharmaceutical comprising the composition according to claim 6. 請求項１または２に記載のサクラ亜科の植物がスモモであることを特徴とする血糖値上昇抑制組成物。A composition for suppressing an increase in blood sugar level, wherein the plant of the subfamily Sakura family according to claim 1 or 2 is a plum. 請求項８に記載の組成物を含有する飲食品又は、医薬部外品、医薬品。A food or drink, a quasi-drug, or a pharmaceutical comprising the composition according to claim 8. サクラ亜科の植物（ウメ以外のモモ、アンズ、スモモ）の葉を含有し、糖尿病、肥満の予防・改善、ダイエットの用途の旨を示す表示が付された飲食品又は、医薬部外品、医薬品。A food or drink or quasi-drug that contains leaves of plants of the subfamily Sakura (peaches other than plums, apricots, plums) and is labeled with diabetes, obesity prevention / improvement, diet indications, Pharmaceuticals.
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2802434B2 (en) * 1989-03-16 1998-09-24 一丸ファルコス株式会社 Lipid peroxide production inhibitor consisting of plant extract
JP2002524480A (en) * 1998-09-15 2002-08-06 コリア インスティテュート オブ サイエンス アンド テクノロジー Bioflavonoids as hypoglycemic agents
JP2003183120A (en) * 2001-12-17 2003-07-03 Ichimaru Pharcos Co Ltd Active oxygen scavenger or cosmetic composition
CN1528159A (en) * 2003-09-26 2004-09-15 单仲琢 Peach-Bamboo tea compound and preparing method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2802434B2 (en) * 1989-03-16 1998-09-24 一丸ファルコス株式会社 Lipid peroxide production inhibitor consisting of plant extract
JP2002524480A (en) * 1998-09-15 2002-08-06 コリア インスティテュート オブ サイエンス アンド テクノロジー Bioflavonoids as hypoglycemic agents
JP2003183120A (en) * 2001-12-17 2003-07-03 Ichimaru Pharcos Co Ltd Active oxygen scavenger or cosmetic composition
CN1528159A (en) * 2003-09-26 2004-09-15 单仲琢 Peach-Bamboo tea compound and preparing method

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6012060226; 五明紀春: '食物生理機能の最前線-alpha-グルコシダ-ゼ活性制御による糖尿病治療食の開発指針-' 埼臨技会誌 Ｖｏｌ．５０，Ｎｏ．２, 2003, Ｐａｇｅ．９０ *
JPN6012060229; ＨＥＮＮＩＮＧ　Ｗ　ｅｔ　ａｌ: 'Ｆｌａｖｏｎｏｌｇｌｙｋｏｓｉｄｅ　ｄｅｒ　Ａｐｒｉｋｏｓｅｎ　（Ｐｒｕｎｕｓ　ａｒｍｅｎｉａｃａ　Ｌ．）　ｕｎｄ　ｄｅｒ　Ｐｆｉｒｓｉｃｈｅ　（Ｐｒｕｎｕｓ　ｐｅｒｓｉｃａ　Ｂａｔｓｃｈ）．　１３．' Ｚ　Ｌｅｂｅｎｓｍ　Ｕｎｔｅｒｓ　Ｆｏｒｓｃｈ Ｖｏｌ．１７１，Ｎｏ．３, 1980, Ｐａｇｅ．１８３-１８８ *
JPN6012060232; Ｋｉｍ，Ｊｏｎｇ-Ｓａｎｇ　ｅｔ　ａｌ: 'Ｉｎｈｉｂｉｔｉｏｎ　ｏｆ　alpha-ｇｌｕｃｏｓｉｄａｓｅ　ａｎｄ　alpha-ａｍｙｌａｓｅ　ｂｙ　Ｌｕｔｅｏｌｉｎ，　ａ　ｆｌａｖｏｎｏｉｄ' Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ ６４（１１）, 2000, ｐｐ．２４５８-２４６１ *
JPN6012060234; Ｗａｔａｎａｂｅ， Ｊｕｎ ｅｔ ａｌ: 'Ｉｓｏｌａｔｉｏｎ ａｎｄ ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ alpha-ｇｌｕｃｏｓｉｄａｓｅ ｉｎｈｉｂｉｔｏｒｓ ｆｒｏｍ Ｔｏｃｈｕ-ｃｈａ （Ｅｕｃｏｍｍｉａ ｕｌｍｏｉｄｅｓ）' ，Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ ６１（１）, 1997, ｐｐ．１７７-１７８ *

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