JP2008125642A - Drug administration device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a drug administration device for surely administering a drug to a desired site to be dosed. <P>SOLUTION: The drug administration device A is equipped with: a drug administration device main body 1 supplied into a celom; a housing chamber 3 provided inside the drug administration device main body 1; a movable wall 5 formed of a permanent magnet and freely movably disposed inside the housing chamber 3; a drug housing chamber 3a which houses an administration drug 8 and is composed of a space surrounded by the inner wall of the housing chamber 3 and the movable wall 5 while the movable wall 5 is moved to one end side of a moving range; a drug administering port 6 provided on the other end side of the moving range of the movable wall 5 in the housing chamber 3 and for communicating the housing chamber 3 with the outside; a sealing plug 7 fitted to the drug administering port 6 in a clearance fit condition; spiral coils 9 and 10 formed on both side walls (the surface 2a of a fixed wall 2 and the inner surface 1a of the drug administration device main body 1) of the moving range of the movable wall 5 in the housing chamber 3 by using the technique of manufacturing a three-dimensional solid circuit board; and an excitation circuit 31 for energizing the coils 9 and 10 in accordance with trigger input and generating electromagnetic force for moving the movable wall 5 to the other end side of the moving range. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a dispensing device.

  This type of dispensing device includes a main unit in which various components such as observation means for observing the inside of a body cavity are disposed inside the housing, and a mechanism for storing the drug and storing the stored drug. A medical capsule device composed of a drug unit has been conventionally proposed (see, for example, Patent Document 1).

  In the medical capsule device disclosed in the above-mentioned patent document, an ejection nozzle for ejecting and ejecting a medicine filled in the medicine unit to the outside and an ejection for pushing the medicine and ejecting the medicine to the outside from the medicine unit The injection port of this injection nozzle is closed with a soluble film formed of a component that dissolves in the body cavity.

When it is desired to administer a desired site in a body cavity using this medical capsule device, the drug unit in which the drug is filled and the spray nozzle is covered with a soluble film is combined with the main unit. When the subject swallows the medical capsule device, the medical capsule device moves in the body cavity of the subject by its peristaltic motion. Since the dissolvable film covering the injection port of the drug unit is formed of a component that is dissolved in the body cavity, dissolution starts as soon as the subject swallows, and eventually the injection port is opened. When the medical capsule device moves to the dosing site in the body cavity and sends a medication command to the main body unit, the main body unit activates the release mechanism of the medicinal unit so that the medicine filled in the medicinal unit is loaded. It is designed to be ejected outside (inside the body cavity).
JP 2005-185536 A (paragraph numbers [0017]-[0033], [0038]-[0040] and FIG. 1)

  In the above-described medical capsule device, since the injection port of the drug unit is covered with a soluble film dissolved in the body cavity, the time until the soluble film is dissolved and the injection port is opened. Because there are individual differences, the drug leaks before reaching the desired dosing site, or all of the soluble film is not dissolved when the dosing site is reached, so it is not possible to dispense all the drugs at the dosing site There was also a possibility.

  The present invention has been made in view of the above-described problems, and an object of the present invention is to provide a dosing device that can reliably dispense a desired dosing site.

  In order to achieve the above object, the invention of claim 1 is characterized in that a dosing device body to be put into a body cavity, a storage chamber provided in the dosing device body, and a permanent magnet are formed in the storage chamber. A movable wall that is movably disposed, and a space that is surrounded by the inner wall and the movable wall of the storage chamber in a state in which the movable wall is moved to one end side of the moving range, and a drug storage chamber that stores a medicine for medication, A dispensing port provided at the other end of the movable range of the movable wall in the storage chamber and communicating the storage chamber with the outside, a sealing plug loosely fitted to the dispensing port, and both sides of the movable range of the movable wall in the storage chamber A spiral coil formed using 3D circuit board manufacturing technology on the wall and an electromagnetic force that moves the movable wall to the other end of the moving range by supplying power to the coil in response to a trigger input And excitation means for generating

  The invention of claim 2 is characterized in that, in the invention of claim 1, the sealing plug is made of a material that can be dissolved by Joule heat generated in the coil, and a part of the coil is formed in the vicinity of the dosing port. And

  According to the first aspect of the present invention, the exciting means receives the trigger input and supplies electric power to the coil, and the movable wall made of the permanent magnet is moved to the other end side of the moving range by the electromagnetic force generated by the coil. Therefore, when the movable wall moves to the other end side of the moving range, the pressure inside the drug storage chamber is increased, and the sealing plug loosely fitted to the medication port is pushed out to open the medication port. In addition, there is an effect that the medicine accommodated in the medicine accommodating chamber can be introduced to the outside (inside the body cavity) through the medication port. Therefore, since the sealing plug that closes the dosing port does not come off before reaching the loading position of the drug, the drug does not leak before the loading position, and when it reaches the loading position Since the sealing plug is removed and the dosing port is reliably opened, there is an effect that the medicine can be administered smoothly.

  According to the invention of claim 2, the sealing plug is melted by Joule heat generated in the coil when the excitation means energizes the coil, thereby loosening the fit between the sealing plug and the medication port. There is an effect that can be easily removed. Therefore, the fit before the sealing plug is dissolved can be tight, and there is also an effect that the medicine can be prevented from leaking from the gap between the sealing plug and the medication port.

  Embodiments of the present invention will be described below with reference to FIGS.

  FIG. 1 is a schematic cross-sectional view of a dosing device A according to the present embodiment. This dosing device A is a main body of a dosing device formed in a capsule shape from a heat-resistant material such as ceramic or polyether ether ketone (PEEK). 1 is provided.

  The inside of the prescription device main body 1 is divided into two left and right accommodation chambers 3 and 4 by a fixed wall 2 provided at an intermediate portion in the longitudinal direction. Further, in the storage chamber 3 on the left side in the drawing, a movable wall 5 made of a permanent magnet formed in a planar shape slightly smaller than the cross section of the storage chamber 3 is disposed so as to be movable in the longitudinal direction of the storage chamber 3. .

  Here, from a space surrounded by the inner wall of the storage chamber 3 and the wall surface of the movable wall 5 on the side opposite to the fixed wall 2, a drug storage chamber 3 a for storing the medication 8 is formed. Also, the medication apparatus body 1 is formed with a medication port 6 that communicates the medicine storage chamber 3a with the outside at the end on the side of the storage chamber 3 among the opposite ends in the longitudinal direction. A sealing plug 7 made of a material (for example, beef tallow) that is dissolved at a predetermined temperature (for example, 40 to 45 ° C.) higher than the temperature in the body cavity is in the dosing port 6 in a state of clearance fit. Is inserted from the outside (floating fitting). The dosing device main body 1 is formed with an air vent opening hole (not shown) for communicating the space between the movable wall 5 and the fixed wall 2 with the outside.

  On the other hand, on the inner surface 1a on one end side in the longitudinal direction of the prescription device main body 1 and the surface 2a on the storage chamber 4 side of the fixed wall 2 among the walls surrounding the storage chamber 3, a manufacturing technique for a three-dimensional circuit board described later is applied. The spiral coils 9 and 10 are formed by using them.

  FIG. 3 shows a schematic shape of the coil 9 formed on the surface 2a of the fixed wall 2. The outer end of the coil 9 serves as a terminal 9a to which a battery 34 described later is connected, and the inner end is a through-hole. It is electrically connected to the conductive pattern 11 formed on the back surface through the hole 2b. The conductive pattern 11 is electrically connected to one end side of a conductive portion 12 made of a metal plating layer formed along the longitudinal direction on the top of the storage chamber 3, and the other end side of the conductive portion 12 is a dosing device. It is electrically connected to a conductive pattern 13 formed on the outer surface of the prescription device main body 1 through a through hole 1b provided on one end surface in the longitudinal direction of the main body 1. The conductive pattern 13 is formed from the outer peripheral side to the center side on the outer surface of one end portion in the longitudinal direction of the dosing device body 1, and the end on the center side is a through hole 1 c provided at one end portion in the longitudinal direction of the dosing device body 1. Is electrically connected to the inner peripheral end of the coil 10 formed on the inner surface 1a of the dosing device body 1. The coil 10 is formed in a spiral shape like the coil 9, and the end portion on the outer peripheral side of the coil 10 is connected to a conductive portion 14 made of a metal plating layer formed along the longitudinal direction at the bottom of the storage chamber 3. ing. Further, a terminal 15 electrically connected to the conductive portion 14 is formed on the surface 2a of the fixed wall 2, and the coils 9 and 10 are connected in series between the terminal 15 and the terminal 9a. . In addition, the conductive pattern 13 provided on the outer surface of the prescription device main body 1 is covered with an insulating layer (not shown) to ensure insulation.

  On the other hand, in the storage chamber 4 on the right side of the prescription device main body 1, a control circuit 30 for receiving a trigger input and performing a prescription operation is stored. The control circuit 30 includes a switch element (not shown) connected between the terminals 9a and 15 via the battery 34, and controls on / off of the switch element to turn on / off the energization of the coils 9, 10. A transmission / reception circuit 32 for transmitting and receiving radio signals via an antenna 33 between an excitation circuit 31 (excitation means) to be turned off and a remote control device (not shown) provided outside the body of the subject, and the outside of the prescription device main body 1 And a camera 35 that picks up images of the above. The transmission / reception circuit 32 transmits the image data input from the camera 35 at a predetermined time interval to the external remote control device by a radio wave signal, and receives the medication command transmitted from the remote control device by the radio signal. A medication command is output to the excitation circuit 31. In the excitation circuit 31, when a medication command (trigger input) is given from the transmission / reception circuit 32, the switch element is turned on, and the DC voltage of the battery 34 is applied to the coils 9, 10 to generate a magnetic field in the coils 9, 10. Let At this time, a magnetic field that repels the magnetic pole of the movable wall 5 is generated in the coil 9, and a magnetic field that attracts the magnetic pole of the movable wall 5 is generated in the coil 10. Since the winding method and the direction of the excitation current are set, the movable wall 5 moves the moving range in the storage chamber 3 from one end side (right side in FIG. 1) to the other end side (left side) by the magnetic field generated in the coils 9 and 10. ).

  The dosing device A has the above-described configuration, and a method for administering a drug into the body cavity of a subject using the dosing device A of the present embodiment will be described below.

  In the state where the movable wall 5 is moved to the fixed wall 2 side in the storage chamber 3 of the prescription device main body 1, the drug storage chamber 3 a surrounded by the inner wall of the storage chamber 3 and the movable wall 5 is filled with the drug from the prescription port 6. Thereafter, the sealing plug 7 is fitted into the dosing port 6 to close the dosing port 6 (see FIG. 1).

  When the subject swallows the medication device body 1, the medication device body 1 moves in the body cavity of the subject by its peristaltic motion. In the medication apparatus main body 1, images of the camera 35 are transmitted to an external remote control device at regular time intervals, and by displaying the image of the camera 35 on the monitor on the remote control device side, the medication person in charge can display the image of the camera 35. The current position of the main body 1 can be grasped. Therefore, when the person in charge of medication confirms that the medication device main body 1 has reached the medication position based on the monitor image of the remote control device, the medication operator is operated to transmit a medication command by a radio signal.

  At this time, in the medication apparatus main body 1, the medication command received by the transmission / reception circuit 32 is input to the excitation circuit 31, and the excitation circuit 31 turns on a switch element (not shown) so that the DC voltage of the battery 34 is applied to the coils 9 and 10. The magnetic field is generated by the coils 9 and 10. Here, a magnetic field that repels the magnetic pole of the permanent magnet that constitutes the movable wall 5 is generated in the coil 9, and a magnetic field that attracts the magnetic pole of the permanent magnet that constitutes the movable wall 5 is generated in the coil 10. Therefore, an electromagnetic force that moves the movable wall 5 to the left in FIG. 1 is generated by the magnetic field of the coils 9 and 10.

  When the movable wall 5 receives the electromagnetic force and moves to the left side in FIG. 1, the medicine 8 accommodated in the medicine accommodating chamber 3a is compressed, and the internal pressure rises. The sealing plug 7 loosely fitted to 6 is pushed outward, and the medication port 6 is opened. Thereafter, when the movable wall 5 moves to the vicinity of the end on one end side in the longitudinal direction of the medication apparatus body 1, the medicine 8 accommodated in the medicine accommodation chamber 3 a is moved from the medication port 6 to the outside (inside the body cavity) with the movement of the movable wall 5. ) (See FIG. 2).

  Since the sealing plug 7 is formed of a material such as beef tallow (melting point: 40 to 45) that can be dissolved by Joule heat generated in the coil 10 formed around the dosing port 6, the coil 10 is energized. At this time, the surface of the sealing plug 7 is dissolved, so that the fit between the sealing plug 7 and the dosing port 6 is loosened so that the sealing plug 7 can be easily detached. Therefore, the fit before the sealing plug 7 is dissolved can be set tightly, and the drug 8 leaking from the gap between the sealing plug 7 and the medication port 6 can be reduced.

  Thus, in this embodiment, when the person in charge of medication sends a medication command using the remote control device outside the body cavity of the subject, the medication device A energizes the coils 9 and 10 to move the movable wall 5. Since the dispensing operation is performed by moving the, the variation in the timing of pushing out the sealing plug 7 to release the drug 8 is small, and the timing of dosing is strictly controlled to ensure the desired dosing site. A drug can be administered. Further, since the movable wall 5 is driven by the magnetic field generated in the coils 9 and 10, the movable wall 5 can be driven with a substantially constant force, and the drug 8 is released from the medication port 6 at a substantially constant flow rate. Can do.

  By the way, although the above-mentioned coils 9 and 10 are formed using the manufacturing technique of a three-dimensional three-dimensional circuit board, the manufacturing technique is demonstrated with reference to FIGS.

  FIG. 4 is a flowchart showing an outline of a method for manufacturing a three-dimensional circuit board. The three-dimensional three-dimensional circuit board is formed by a molding process (S1) in which a resin material is injection-molded to mold a desired three-dimensional substrate 21, and a physical vapor deposition method such as sputtering, vapor deposition, or ion plating on the surface of the substrate 21. A metallization process (S2) for forming the conductive thin film 22, a laser process (S3) for separating the circuit part / non-circuit part by a high energy beam (in this embodiment, a laser beam), and plating of the circuit part It is manufactured by sequentially performing each step of the plating process (S4) for forming the plating layer 23 by increasing the film thickness and the non-circuit part etching process (S5).

  FIGS. 5A to 5C and FIGS. 6A and 6B show the surface treatment of the three-dimensional circuit board B in each of the above steps. First, FIG. 5A shows a molding step (S1) of the substrate 21, and the substrate 21 having a desired three-dimensional shape is molded by injection molding an insulating synthetic resin. Here, as the molding material of the substrate 21, for example, an aromatic polyamide or liquid crystalline polyester is used in the case of a thermoplastic resin, an epoxy resin or a saturated polyester is used in the case of a thermosetting resin, and a nitriding is used in the case of a ceramic. Alumina or the like is used. The molding method of the substrate 21 is not limited to injection molding, and a molding method such as extrusion molding or transfer molding may be used.

  Next, FIG. 5B shows a metallization process step (S2). For example, the surface of the substrate 21 is made conductive by a physical vapor deposition method (PVD method) such as sputtering, vacuum deposition, or ion plating using copper as a target. A thin film 22 is formed. However, it may be performed by other methods such as a chemical vapor deposition method without being limited to the physical vapor deposition method. In addition to copper, the conductive thin film 22 may use a single metal such as nickel, gold, aluminum, titanium, molybdenum, chromium, tungsten, tin, or lead, or an alloy such as brass or NiCr.

  FIG. 5C shows a laser processing step (S3). A boundary portion between the circuit portion 23a and the non-circuit portion 23b in the conductive thin film 22 is irradiated with a high energy beam, for example, a laser beam which is an electromagnetic wave beam. The conductive thin film 22 is removed by evaporation, and the circuit portion 23a and the non-circuit portion 23b are separated by the removal portion 23c to form a predetermined circuit pattern.

  Next, FIG. 6A is a plating process step (S4), in which power is supplied to the circuit portion 23a and current flows, and the portion of the circuit portion 23a is thickened by, for example, electrolytic copper plating. It is formed. At this time, no current flows through the non-circuit portion 23b, and the portion of the non-circuit portion 23b is not plated, so that the film thickness remains as it is. Note that nickel gold plating or the like may be formed as the plating layer 24.

  Next, FIG. 6B shows an etching process step (S5). By etching the entire circuit pattern forming surface, the non-circuit portion 23b is removed and a three-dimensional circuit board on which the circuit pattern is formed is completed. Therefore, the spiral coils 9 and 10 can be formed on the inner surface 1a of the one end portion of the dosing device body 1 and the surface 2a of the fixed wall 2 by using such a manufacturing technique.

  It should be noted that a wide variety of different embodiments can be configured without departing from the spirit and scope of the present invention, and the present invention is not limited to a specific embodiment.

It is a schematic sectional drawing of the medication apparatus of this embodiment. It is a schematic sectional drawing which shows the state after dosing same as the above. It is a top view which shows schematic structure of a coil same as the above. It is a flowchart which shows the outline | summary of the manufacturing method of a coil same as the above. (A)-(c) It is a perspective view which shows the mode of the surface treatment in each process same as the above. (A) (b) It is a perspective view which shows the mode of the surface treatment in each process same as the above.

Explanation of symbols

A Dosing device 1 Dosing device body 1a Inner surface 2 Fixed wall 2a Surface 3 Storage chamber 3a Drug storage chamber 5 Movable wall 6 Dosing port 7 Seal plug 8 Drug 9, 10 Coil 30 Control circuit 31 Excitation circuit

Claims (2)

  A dosing device body to be placed in a body cavity, a storage chamber provided inside the dosing device body, a movable wall formed by a permanent magnet and movably disposed inside the storage chamber, and the movable wall comprising: A space surrounded by the inner wall and the movable wall of the storage chamber in a state of moving to one end side of the movement range, a drug storage chamber for storing a medicine for medication, and the movement range of the movable wall in the storage chamber A three-dimensional three-dimensional circuit board on both side walls of the movable range of the movable wall in the accommodating chamber; a prescription opening provided on the end side and communicating with the outside of the accommodating chamber; A spiral coil formed by using the manufacturing technique, and excitation means for generating an electromagnetic force that energizes the coil in response to a trigger input and moves the movable wall to the other end side of the moving range. A dosing device comprising:   The dosing device according to claim 1, wherein the sealing plug is made of a material that can be dissolved by Joule heat generated in the coil, and a part of the coil is formed in the vicinity of the dosing port.

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