JP2008089396A - Gamma camera system - Google Patents

Gamma camera system Download PDF

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JP2008089396A
JP2008089396A JP2006270369A JP2006270369A JP2008089396A JP 2008089396 A JP2008089396 A JP 2008089396A JP 2006270369 A JP2006270369 A JP 2006270369A JP 2006270369 A JP2006270369 A JP 2006270369A JP 2008089396 A JP2008089396 A JP 2008089396A
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gamma camera
detector
camera system
gamma
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JP4370420B2 (en
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Takashi Shirohata
崇 白旗
Ryota Obara
亮太 小原
Tetsuo Nakazawa
哲夫 中澤
Yasushi Miyazaki
宮崎  靖
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Hitachi Healthcare Manufacturing Ltd
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Hitachi Medical Corp
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a gamma camera system capable of effectively calculating the image reconstruction processing. <P>SOLUTION: A plurality of gamma ray detecting parts 10 are prepared in which a plurality of gamma ray detectors constituting a Compton gamma camera are arranged. Each gamma ray detector is capable of positioning variably so as to closely bring into contact corresponding to the shape or size of an object by the detector position control part 14. The gamma ray detector 10 is made capable of accommodating the whole body of the object. According to the use, a part of the body may be removed from the imaging object e.g. the head. At the sitting status, the plurality of detectors may be closely brought into contact with the imaging object. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

本発明は、ガンマ線などの放射線を放出する核種から放射されるガンマ線などの放射線を検出して画像化するガンマカメラに関わる。   The present invention relates to a gamma camera that detects and images radiation such as gamma rays emitted from nuclides that emit radiation such as gamma rays.

放射線放出核種から放射される放射線を検出して画像化する機器の代表的なものとして、ポジトロン断層撮像(Positron Emission Tomography, PET)装置があげられる。PET装置では、被写体に投与されたトレーサー中の陽電子放出核種が崩壊して陽電子を放出する。放出された陽電子が近傍に存在する原子中の電子と対消滅し、電子の静止質量に等しいエネルギーのガンマ線を反対方向に2個放出する。放出された2個のガンマ線を周囲に配置された複数の検出器のうちの2つで同時に検出する。2つの検出器を結ぶ直線上にガンマ線源が存在することになり、複数のガンマ線ペアに対して収集したデータから、ガンマ線源を画像化することができる。   A representative example of a device that detects and images radiation emitted from a radiation emitting nuclide is a positron emission tomography (PET) apparatus. In the PET device, the positron emitting nuclide in the tracer administered to the subject decays and emits positrons. The emitted positron annihilates with the electron in the nearby atom, and emits two gamma rays with energy equal to the rest mass of the electron in the opposite direction. Two emitted gamma rays are detected simultaneously by two of a plurality of detectors arranged around the gamma ray. A gamma ray source exists on a straight line connecting the two detectors, and the gamma ray source can be imaged from data collected for a plurality of gamma ray pairs.

一般にPET装置では、検出器と被写体の距離を遠ざければ遠ざけるほど画像の解像度(空間分解能)が向上し、検出器と被写体の距離を近づければ近づけるほど感度(検出効率)が向上する。従って、解像度と感度を同時に向上させるのは困難である。最近、検出器を深さ方向に多層に積み重ねることで検出器と被写体の距離を近づけても、解像度の低下を減少させることができるような技術も開発されつつある(例えば、特許文献1)。
特許第3697340号公報
In general, in a PET apparatus, the image resolution (spatial resolution) increases as the distance between the detector and the subject increases, and the sensitivity (detection efficiency) increases as the distance between the detector and the subject decreases. Therefore, it is difficult to improve resolution and sensitivity at the same time. Recently, a technique has been developed that can reduce the decrease in resolution even if the distance between the detector and the subject is reduced by stacking detectors in multiple layers in the depth direction (for example, Patent Document 1).
Japanese Patent No. 3697340

しかしながらデータ量が増加し画像再構成に膨大な演算時間を要するという点に配慮されていなかった。   However, no consideration has been given to the fact that the amount of data increases and enormous computation time is required for image reconstruction.

本発明の目的は、画像再構成処理を効率的に演算可能なガンマカメラを提供することにある。   An object of the present invention is to provide a gamma camera that can efficiently calculate image reconstruction processing.

上記目的は、被写体に注入した薬剤に含まれる所定の核種から放出される放射線を検出して画像化するガンマカメラシステムであって、複数のデータ収集の可能な検出器と、被写体の形状や大きさに合わせて前記複数の検出器の配置を可変設定する手段と、前記複数の検出器によって収集されたデータをもとに前記被写体の診断画像を再構成する手段と、前記再構成された診断画像を表示する手段とを備えたことを特徴とするガンマカメラシステムによって達成される。   The above-described object is a gamma camera system that detects and images radiation emitted from a predetermined nuclide contained in a medicine injected into a subject, and includes a plurality of detectors capable of collecting data and the shape and size of the subject. Means for variably setting the arrangement of the plurality of detectors, means for reconstructing a diagnostic image of the subject based on data collected by the plurality of detectors, and the reconstructed diagnosis It is achieved by a gamma camera system characterized by comprising means for displaying an image.

本発明の実施形態について図面を用いて説明する。図1に本発明によるガンマカメラシステムの一例を示す。ガンマカメラシステムはガンマ線源から入射したガンマ線についてコンプトン散乱を起こさせ、発生した散乱ガンマ線(および必要に応じて反跳電子)を検出する複数のガンマ線検出部10と、それぞれの検出器に接続され、検出した散乱ガンマ線(および必要に応じて反跳電子)データを収集するデータ収集部11と、データ収集部11で得られた情報を統合するデータ統合部12と、データを記憶するデータ記憶部13と、検出器の位置情報を取得する検出器位置制御部14と、検出器位置情報を記憶する検出器位置情報記憶部15と、データ記憶部13および検出器位置情報記憶部15に記憶された情報を用いて画像再構成演算を行う画像再構成演算部16と、再構成された画像を表示する表示装置17からなる。さらに、各ガンマ線検出部10は、図2に示すように、例えば前段検出器20および後段検出器21の2つの検出器とそれぞれの検出器で得られるデータを読み出す前段用データ読出部22および後段用データ読出部23からなる。前段用データ読出部22および後段用データ読出部23はデータ収集部11に接続される。ここでは、前段、後段2つの検出器からなるコンプトンカメラを例に図示したが、多段構造をとる場合でも同様である。   Embodiments of the present invention will be described with reference to the drawings. FIG. 1 shows an example of a gamma camera system according to the present invention. The gamma camera system is connected to each detector with a plurality of gamma ray detectors 10 that cause Compton scattering on the gamma rays incident from the gamma ray source and detect the generated scattered gamma rays (and recoil electrons if necessary), A data collection unit 11 that collects the detected scattered gamma ray (and recoiled electrons if necessary) data, a data integration unit 12 that integrates information obtained by the data collection unit 11, and a data storage unit 13 that stores data Detector position control unit 14 for acquiring detector position information, detector position information storage unit 15 for storing detector position information, data storage unit 13 and detector position information storage unit 15 The image reconstruction calculation unit 16 performs image reconstruction calculation using information, and the display device 17 displays the reconstructed image. Further, as shown in FIG. 2, each gamma ray detection unit 10 includes, for example, two detectors, a front-stage detector 20 and a rear-stage detector 21, and a front-stage data reading unit 22 and a rear-stage data that read data obtained by the respective detectors. The data read unit 23 is used. The pre-stage data reading unit 22 and the post-stage data reading unit 23 are connected to the data collecting unit 11. Here, a Compton camera including two detectors at the front and rear stages is illustrated as an example, but the same applies to a case of a multistage structure.

本発明の各実施形態について図面を用いて説明する。なお、ここでは、ガンマ線放出核種で標識した薬剤を人体に投与し、人体内から放出されるガンマ線を検出器して画像化する場合を例に説明する。   Embodiments of the present invention will be described with reference to the drawings. Here, an example will be described in which a drug labeled with a gamma-ray emitting nuclide is administered to a human body, and gamma rays emitted from the human body are detected and imaged.

本発明の第1の実施形態について説明する。第1の実施形態では全身を撮影する場合を例に説明する。本実施形態におけるガンマカメラの外観を図3に示す。本ガンマカメラは上蓋部30と下蓋部31からなり、図4に示すように開閉式となっていて、内部に被写体40が入り撮影することが可能である。また、ガンマ線検出部10が内部に配置されている。図5を用いて、カメラの内部構造を説明する。図5は図3で示したガンマカメラを短軸方向に切断した断面構造(破線50で切断した断面構造)を示している。内部には小型の検出器が複数配置される(検出器51など)。各検出器には伸縮式のアーム52とジョイント53が接続されており、ジョイント53は例えば球状の形状をとるなどし、任意の角度への自由な回転が可能で、検出器を被写体の表面へ密着させられる構造をとる。ジョイント53の位置と角度を認識することで、検出器の位置と角度が求められる。求めた検出器の位置と角度情報はいった検出器位置情報記憶部15に記憶されたあと、再構成演算に必要なデータ収集が完了した時点で画像再構成演算部16に渡され、検出器の位置情報が画像再構成演算に反映される。被写体の大きさが異なる場合には、図6に示すように、例えば大きな被写体60についてはすべての検出器を用いて撮影を行い、小さな被写体61については必要数の検出器のみを用いて撮影するようにしてもよい。ここで検出器62〜69が未使用である。これにより被写体の形状や大きさに関わらず検出器と被写体を密着させた検出器配置が可能となる。   A first embodiment of the present invention will be described. In the first embodiment, a case where the whole body is imaged will be described as an example. The appearance of the gamma camera in this embodiment is shown in FIG. This gamma camera is composed of an upper lid portion 30 and a lower lid portion 31 and is of an openable type as shown in FIG. 4, so that the subject 40 can enter and take a picture. A gamma ray detection unit 10 is disposed inside. The internal structure of the camera will be described with reference to FIG. FIG. 5 shows a cross-sectional structure (cross-sectional structure cut along a broken line 50) of the gamma camera shown in FIG. 3 cut in the short axis direction. A plurality of small detectors are arranged inside (detector 51 and the like). Each detector is connected to a telescopic arm 52 and a joint 53. The joint 53 has, for example, a spherical shape, and can freely rotate to any angle. Takes a structure that can be closely attached. By recognizing the position and angle of the joint 53, the position and angle of the detector are obtained. The obtained detector position and angle information is stored in the detector position information storage unit 15 and then passed to the image reconstruction calculation unit 16 when data collection necessary for the reconstruction calculation is completed. The position information is reflected in the image reconstruction calculation. When the subject size is different, as shown in FIG. 6, for example, a large subject 60 is photographed using all detectors, and a small subject 61 is photographed using only a necessary number of detectors. You may do it. Here, the detectors 62 to 69 are unused. As a result, a detector arrangement in which the detector and the subject are brought into close contact with each other regardless of the shape and size of the subject is possible.

被写体内部から放出されたガンマ線は検出器51で検出され、データ収集部、データ統合部を経由して画像再構成演算部にて画像化される。画像再構成法としては例えば、特許文献2などに記載の方法を用いても良い。ここで、被写体と検出器とを密着させることにより被写体内から放出されたガンマ線はほとんどすべて検出器へ入射することになる。従って、従来の検出器と被写体を密着させる機構をもたないカメラに比べ、感度を向上させることができる。また、コンプトンカメラは前段検出器と被写体の距離が近いほど解像度が向上する。   The gamma rays emitted from the inside of the subject are detected by the detector 51 and imaged by the image reconstruction calculation unit via the data collection unit and the data integration unit. As the image reconstruction method, for example, the method described in Patent Document 2 may be used. Here, by bringing the subject and the detector into close contact with each other, almost all of the gamma rays emitted from the subject enter the detector. Therefore, the sensitivity can be improved as compared with a conventional camera that does not have a mechanism for closely contacting the detector and the subject. In addition, the resolution of the Compton camera is improved as the distance between the front detector and the subject is shorter.

以上より、本構造をもつカメラでは画像の解像度と感度を同時に向上させることが可能となる。従って、解像度向上による診断能の向上と、感度向上により投与する薬剤量が減らせることで被写体の被曝量の低減効果が期待できる。また、全身を同時に撮影することが可能なため、撮影時間の短縮が図れる。さらに、カメラの上蓋部30と下蓋部31の内部には放射線を遮蔽する遮蔽材54が内装されている。これにより被写体内から放出されるガンマ線を遮蔽材54で遮蔽することができ、カメラ外部への漏洩線量を低減させることができるため、カメラ周辺で作業する人の被曝量の低減が可能となる。
特願2006-164527号公報
As described above, the camera having this structure can simultaneously improve the resolution and sensitivity of the image. Therefore, an effect of reducing the exposure dose of the subject can be expected by improving the diagnostic ability by improving the resolution and reducing the amount of drug to be administered by improving the sensitivity. In addition, since the whole body can be photographed simultaneously, the photographing time can be shortened. Further, a shielding material 54 for shielding radiation is provided inside the upper lid portion 30 and the lower lid portion 31 of the camera. As a result, gamma rays emitted from within the subject can be shielded by the shielding material 54, and the leakage dose to the outside of the camera can be reduced. Therefore, it is possible to reduce the exposure dose of people working around the camera.
Japanese Patent Application No. 2006-164527

本発明の第2の実施形態について説明する。第1の実施形態では被写体の全身をカメラ内部に入れて撮影する場合を説明した。しかし、部分的な撮影だけでよい場合や被写体が閉所恐怖症の場合などに全身をカメラ内部にいれて撮影するのは好ましくないことがある。第2の実施形態では部分的な撮影が可能なガンマカメラについて説明する。内部に複数の検出器が配置され、被写体に密着させられる機構を持っている部分については第1の実施形態と同様である。本実施形態では、カメラが部分的に開閉する機構をもつ。図3に示したガンマカメラの上蓋部30が図7に示すように複数領域(例えば領域70〜75)に分かれており、用途に応じていくつかの領域のみを閉じて撮影する。例えば、頭部以外を撮影したい場合、領域70は開いた状態にし、領域71〜74を閉じた状態にして撮影する。これにより、被写体が閉所恐怖症の場合にも、頭部が外に出ていることにより、恐怖心を緩和するなどの効果が得られる。   A second embodiment of the present invention will be described. In the first embodiment, the case has been described in which the entire body of the subject is photographed with the camera inside. However, there are cases where it is not preferable to take the whole body inside the camera when only partial photographing is required or when the subject has claustrophobia. In the second embodiment, a gamma camera capable of partial photographing will be described. A part having a mechanism in which a plurality of detectors are arranged and brought into close contact with the subject is the same as in the first embodiment. In this embodiment, the camera has a mechanism that partially opens and closes. The upper lid 30 of the gamma camera shown in FIG. 3 is divided into a plurality of areas (for example, areas 70 to 75) as shown in FIG. 7, and only some areas are closed and photographed depending on the application. For example, when it is desired to photograph other than the head, the region 70 is opened and the regions 71 to 74 are closed. As a result, even when the subject is claustrophobia, the effect of relieving fear is obtained by the head being out.

第1,第2の実施形態では、被写体が人体であり装置内で被写体が寝ている場合を例に説明したが、もちろん被写体は人体である必要はない。また、人体であったとしても、被写体が寝ている状態で撮影するのではなく、例えば座っている状態、立っている状態に対して、複数検出器を撮影対象部位へ密着するように配置してもよい。   In the first and second embodiments, the case where the subject is a human body and the subject is sleeping in the apparatus has been described as an example. However, the subject need not be a human body. Even if the subject is a human body, the multiple detectors are arranged so as to be in close contact with the region to be imaged, for example, in a sitting state or standing state, instead of shooting while the subject is sleeping. May be.

第1,第2の実施形態では本カメラシステムを診断目的で使用するような場合を例にとり説明した。しかし、診断用だけでなくたとえば放射線治療中のモニタリング用機器として使用してもよい。その場合は、あらかじめ本システムや他の撮像装置により治療箇所を特定する。特定された情報を元に、放射線を照射する方向に位置する検出器のみを被写体に密着させず開けておく。それ以外の周辺の検出器を用いて撮影を行い、表示装置に画像を表示することにより、放射線が正しい位置へ照射されているかをモニターすることが可能となる。   In the first and second embodiments, the case where the present camera system is used for diagnostic purposes has been described as an example. However, it may be used not only for diagnosis but also as a monitoring device during radiotherapy, for example. In that case, a treatment site is specified in advance by this system or another imaging device. Based on the identified information, only the detector located in the radiation irradiation direction is opened without being in close contact with the subject. It is possible to monitor whether or not the radiation is applied to the correct position by photographing using other peripheral detectors and displaying an image on the display device.

以上のとおり説明した実施形態によれば、ガンマカメラの解像度を向上させることができ診断能の向上が期待できる。また感度も向上するため、従来の装置に比べ少ない薬剤投与量での撮影が可能となる。従って、被写体の被曝低減効果が期待できる。撮影時間を短縮する効果も得られる。さらに、カメラ周辺に位置する作業者の被曝量を低減する効果もある。   According to the embodiment described above, it is possible to improve the resolution of the gamma camera and improve the diagnostic ability. Further, since the sensitivity is improved, it is possible to perform imaging with a smaller amount of drug compared to the conventional apparatus. Accordingly, an effect of reducing the exposure of the subject can be expected. The effect of shortening the shooting time can also be obtained. In addition, there is an effect of reducing the exposure dose of workers located around the camera.

本発明のガンマカメラシステムの一例を示す図。The figure which shows an example of the gamma camera system of this invention. ガンマ線検出部の構成の一例を示す図。The figure which shows an example of a structure of a gamma ray detection part. 第1の実施形態におけるガンマカメラの外観図。1 is an external view of a gamma camera according to a first embodiment. 第1の実施形態のおけるガンマカメラの外観図。1 is an external view of a gamma camera according to a first embodiment. 本発明のガンマカメラの内部構造説明図。FIG. 3 is an explanatory diagram of the internal structure of the gamma camera of the present invention. 本発明のガンマカメラの内部構造説明図。FIG. 3 is an explanatory diagram of the internal structure of the gamma camera of the present invention. 第2の実施形態におけるガンマカメラの外観図。FIG. 6 is an external view of a gamma camera according to a second embodiment.

符号の説明Explanation of symbols

10 ガンマ線検出部、11 データ収集部、12 データ統合部、13 データ記憶部、14 検出器位置制御部、15 検出器位置情報記憶部、16 画像再構成演算部、17 表示装置   10 gamma ray detection unit, 11 data collection unit, 12 data integration unit, 13 data storage unit, 14 detector position control unit, 15 detector position information storage unit, 16 image reconstruction calculation unit, 17 display device

Claims (3)

被写体に注入した薬剤に含まれる所定の核種から放出される放射線を検出して画像化するガンマカメラシステムであって、
複数のデータ収集の可能な検出器と、
被写体の形状や大きさに合わせて前記複数の検出器の配置を可変設定する手段と、
前記複数の検出器によって収集されたデータをもとに前記被写体の診断画像を再構成する手段と、
前記再構成された診断画像を表示する手段と、
を備えたことを特徴とするガンマカメラシステム。
A gamma camera system for detecting and imaging radiation emitted from a predetermined nuclide contained in a medicine injected into a subject,
A detector capable of collecting multiple data;
Means for variably setting the arrangement of the plurality of detectors according to the shape and size of the subject;
Means for reconstructing a diagnostic image of the subject based on data collected by the plurality of detectors;
Means for displaying the reconstructed diagnostic image;
A gamma camera system characterized by comprising:
請求項1に記載のガンマカメラシステムにおいて、
前記可変設定手段は、前記複数の検出器を前記被写体全体が覆われるように配置し、
前記検出器の周囲を覆う遮蔽材をさらに備えたことを特徴とするガンマカメラシステム。
The gamma camera system according to claim 1,
The variable setting means arranges the plurality of detectors so that the entire subject is covered,
A gamma camera system, further comprising a shielding material that covers the periphery of the detector.
請求項1または2のいずれかに記載のガンマカメラシステムにおいて、
前記検出器で被写体の覆われない部分を任意に指定する手段をさらに備えたことを特徴とするガンマカメラシステム。
The gamma camera system according to claim 1 or 2,
The gamma camera system further comprising means for arbitrarily designating a portion of the subject not covered by the detector.
JP2006270369A 2006-10-02 2006-10-02 Gamma camera system Expired - Fee Related JP4370420B2 (en)

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