JP2008069182A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008069182A5 JP2008069182A5 JP2007315315A JP2007315315A JP2008069182A5 JP 2008069182 A5 JP2008069182 A5 JP 2008069182A5 JP 2007315315 A JP2007315315 A JP 2007315315A JP 2007315315 A JP2007315315 A JP 2007315315A JP 2008069182 A5 JP2008069182 A5 JP 2008069182A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- dideoxy
- ethynyl
- fluoroadenosine
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 5
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 2
- 229910052731 fluorine Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- CEWGLEQAOGZESJ-WGDKSQQYSA-N (2R,3S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3-hydroxy-2-(hydroxymethyl)oxolane-2-carbonitrile Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@H]1C[C@H](O)[C@](CO)(C#N)O1 CEWGLEQAOGZESJ-WGDKSQQYSA-N 0.000 claims 1
- MNTWBYMPFOFDSF-KSBSHMNSSA-N (2R,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)-2H-furan-5-carbonitrile Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@@](CO)(C#N)C=C1 MNTWBYMPFOFDSF-KSBSHMNSSA-N 0.000 claims 1
- QRJLNTMZFHLRQY-KSBSHMNSSA-N (2R,5R)-5-(6-amino-2-fluoropurin-9-yl)-2-(hydroxymethyl)oxolane-2-carbonitrile Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@H]1CC[C@](CO)(C#N)O1 QRJLNTMZFHLRQY-KSBSHMNSSA-N 0.000 claims 1
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-N Pyrophosphoric acid Chemical group OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims 1
- CROLXOWGLQHCDS-KRTXAFLBSA-N [(2R,5R)-2-(6-amino-2-chloropurin-9-yl)-5-ethynyl-2H-furan-5-yl]methanol Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@@](CO)(C#C)C=C1 CROLXOWGLQHCDS-KRTXAFLBSA-N 0.000 claims 1
- AHGUGKZOPNWSMI-KRTXAFLBSA-N [(2R,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-ethynyl-2H-furan-5-yl]methanol Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@@](CO)(C#C)C=C1 AHGUGKZOPNWSMI-KRTXAFLBSA-N 0.000 claims 1
- GHCCTMGSDOFYPV-KRTXAFLBSA-N [(2R,5R)-5-(6-amino-2-chloropurin-9-yl)-2-ethynyloxolan-2-yl]methanol Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1CC[C@](CO)(C#C)O1 GHCCTMGSDOFYPV-KRTXAFLBSA-N 0.000 claims 1
- KLXASYNEJRYFMO-KRTXAFLBSA-N [(2R,5R)-5-(6-amino-2-fluoropurin-9-yl)-2-ethynyloxolan-2-yl]methanol Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@H]1CC[C@](CO)(C#C)O1 KLXASYNEJRYFMO-KRTXAFLBSA-N 0.000 claims 1
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical group OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007315315A JP2008069182A (ja) | 2004-03-24 | 2007-12-06 | ４’−ｃ−置換−２−ハロアデノシン誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004087198 | 2004-03-24 | ||
| JP2004263409 | 2004-09-10 | ||
| JP2007315315A JP2008069182A (ja) | 2004-03-24 | 2007-12-06 | ４’−ｃ−置換−２−ハロアデノシン誘導体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006511319A Division JP4253342B2 (ja) | 2004-03-24 | 2005-03-24 | ４’−ｃ−置換−２−ハロアデノシン誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011142793A Division JP5213194B2 (ja) | 2004-03-24 | 2011-06-28 | ４’−ｃ−置換−２−ハロアデノシン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008069182A JP2008069182A (ja) | 2008-03-27 |
| JP2008069182A5 true JP2008069182A5 (xx) | 2008-09-04 |
Family
ID=39291065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007315315A Pending JP2008069182A (ja) | 2004-03-24 | 2007-12-06 | ４’−ｃ−置換−２−ハロアデノシン誘導体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2008069182A (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9533938B2 (en) | 2007-01-31 | 2017-01-03 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbol esters for the treatment of stroke |
| US10369222B2 (en) | 2012-01-18 | 2019-08-06 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbol esters for the treatment of stroke |
| US9974764B2 (en) | 2007-01-31 | 2018-05-22 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters in the treatment of neoplasms |
| US11696908B2 (en) | 2007-01-31 | 2023-07-11 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters |
| MY186986A (en) | 2007-01-31 | 2021-08-26 | Biosuccess Biotech Co Ltd | Compositions and methods of use of phorbol esters |
| US9636317B2 (en) | 2007-01-31 | 2017-05-02 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters |
| US11564901B2 (en) | 2007-01-31 | 2023-01-31 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbol esters |
| US9550722B2 (en) | 2012-01-18 | 2017-01-24 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbal esters for the treatment of stroke |
| US10099996B2 (en) | 2012-01-18 | 2018-10-16 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters in the treatment of neoplasms |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192749A (en) * | 1990-05-21 | 1993-03-09 | Syntex (U.S.A.) Inc. | 4'-substituted nucleosides |
| JP4076114B2 (ja) * | 1999-05-12 | 2008-04-16 | ヤマサ醤油株式会社 | ４’−ｃ−エチニルプリンヌクレオシド化合物 |
-
2007
- 2007-12-06 JP JP2007315315A patent/JP2008069182A/ja active Pending