JP2008023196A - Puncture tool of biosensor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide the puncture tool of a biosensor that reduces the burden of a subject by easing his/her pains when puncturing his/her skin. <P>SOLUTION: A subject M does not puncture his/her skin with a needle 12 not by himself or herself, but by a rotary mechanism 13 provided on the puncture tool body 10a of a biosensor punctures his/her skin with the needle 12 at a specified position. Since the puncture is made ignoring the subject's feeling of hesitation and also shortening the required time for puncture, it can reduce the subject M's burden by easing his/her pains of puncture. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a biosensor puncture device. More specifically, the present invention relates to a biosensor puncture device that can be used when a chemical substance is measured or analyzed using a biosensor chip or a biosensor cartridge by puncturing a needle at a puncture position of a subject.

  In measurement using a needle-equipped biosensor chip having a needle as a puncture device for performing puncture for sample collection, the sample to be measured is introduced into the hollow reaction part of the biosensor chip from the position punctured by the puncture device. In the hollow reaction part, a biochemical reaction such as an enzyme reaction or an antigen-antibody reaction is caused between the sample and the reagent, and information obtained by the biochemical reaction is output from the biosensor chip to the measuring device to analyze the sample. Is what you do. The measurement using a biosensor chip uses an excellent molecular identification function of a living body, and has been attracting attention as being capable of quick and simple measurement of chemical substances with a small amount of sample. As an example, it is possible to measure blood glucose level (blood glucose level) and urinary glucose level using a measurement method using a biosensor chip, and it is used for home health checkups (self-care) to self-manage and prevent diabetes. Is possible.

As an example of a biosensor chip having a conventional puncture device, there is the following patent document. As shown in FIG. 9, the skin patch described in Patent Document 1 includes two layers 101 and 102 formed on the skin patch 100, and a certain needle, lancet, or cannula, which is a puncture device, is formed on the layer 101. An intrusion device 103 and a pressure ring 104 are attached. Between the two layers 101 and 102, there is a micro passage system 106, and a distribution port 105 is formed substantially at the center. Corresponding to the micropassage system 106, an electrochemical detector 107, a hydrophobic gate 108, and an electro-osmotic pump system 109 are arranged.
JP 2004-520103 A

  However, in the skin patch 100 described in Patent Document 1, for example, when a sample is collected, the subject presses the needle (intrusion device) 103 that is a puncture device against the finger or the like to puncture the subject, and thus the burden is large. Pain relief is desired. Further, since blood must be collected while the needle 103 is stuck in the subject to be examined, there is a problem that an increase in the burden on the subject to be examined can be considered.

  The present invention has been made in view of the above-described problems, and an object of the present invention is to provide a biosensor puncture device that can reduce pain during puncture and reduce the burden on the subject. is there.

  In order to achieve the above-described object, the first feature of the present invention is that in the biosensor puncture device, the rotation is provided with an arm portion having a puncture member and a rotation mechanism for rotating the arm portion. And having a part.

  In the biosensor puncture device configured as described above, the subject can puncture the needle without stumbling by the puncture member, instead of puncturing the needle by himself / herself. Moreover, since the time required for puncture can be shortened, the burden on the subject can be reduced.

  Further, a second feature of the present invention is a biosensor puncture device according to the first feature of the present invention, wherein the arm portion is rotated by the rotation mechanism to place the puncture member in a puncture position. It is characterized by puncturing.

  In the biosensor puncture device thus configured, the arm member is rotated by the rotation mechanism provided in the biosensor device, and the needle provided at the tip of the arm member is punctured at the puncture position. . Therefore, it is possible to puncture accurately at a predetermined puncturing position.

  According to a third aspect of the present invention, there is provided a biosensor puncture device according to the first or second aspect of the present invention, wherein the rotation mechanism includes a motor.

  In the biosensor puncture device configured as described above, the arm member is rotated by the motor, and the needle provided at the tip of the arm member is punctured at the puncture position. The burden on the target person can be reduced. In addition, the needle can be removed immediately after puncturing.

  According to a fourth aspect of the present invention, there is provided a biosensor puncture device according to the first or second aspect of the present invention, wherein the rotating mechanism includes a spring.

  In the biosensor puncture device configured as described above, the arm member is rotated by the restoring force of the spring, and the needle provided at the tip of the arm member is punctured at the puncture position. Can reduce the burden on the subject.

  A fifth feature of the present invention is a biosensor puncture device, wherein the puncture member is a needle in any one of the first to fourth features of the present invention.

  In the biosensor puncture device configured as described above, by using the puncture member as a needle, puncture can be reliably performed and the sample can flow out.

  According to a sixth aspect of the present invention, in the biosensor puncture device according to the fifth aspect of the present invention, the needle and the biosensor chip are separately provided.

  In the biosensor puncture device configured as described above, the puncture device includes both the needle and the biosensor chip, so that the sample that has flowed out after the puncture can be collected smoothly.

  A seventh feature of the present invention is a biosensor puncture device, and in the fifth feature of the present invention, the puncture member is a biosensor cartridge.

  In the biosensor puncture device configured as described above, by using the puncture member as a biosensor cartridge, the puncture and the sample collection can be performed at the same position, and the sample can be reliably collected.

  According to an eighth aspect of the present invention, in the sample collection method, the sample is collected by positioning the biosensor chip at the puncture position in conjunction with the rotation mechanism of the puncture member.

  In the sample collecting method configured as described above, the biosensor chip is positioned at the puncture position in conjunction with the movement of the arm member by the rotation mechanism of the puncture member. For example, after the puncture by the biosensor puncture device As the needle is raised, the biosensor chip is positioned at the puncture position, and the sample that has flowed out by puncture can be collected. Alternatively, when puncturing with a biosensor puncture device, it is possible to position the biosensor chip at the puncture position and immediately collect the sample that has flowed out by puncture.

  According to a ninth feature of the present invention, in the biosensor device, the biosensor puncture device according to the first to seventh features of the present invention is provided.

  In the biosensor device configured in this way, it is possible to puncture reliably and quickly measure the collected sample.

  According to the present invention, the subject can puncture the needle without hesitation by the puncture member, instead of puncturing the needle by himself / herself. Moreover, since the time required for puncture can be shortened, the burden on the subject can be reduced.

DESCRIPTION OF EMBODIMENTS Hereinafter, embodiments according to the present invention will be described in detail with reference to the drawings.
FIG. 1 is a side view showing a first embodiment of the biosensor puncture device of the present invention, and FIGS. 2A to 2C are side views showing steps of a puncture operation when a motor is used as a rotation mechanism. FIGS. 3A to 3D are side views showing steps of a puncturing operation when a spring is used as a rotating mechanism, and FIG. 4 shows another example of a biosensor puncture device according to the present invention. FIG. 5 is a plan view showing an example of a biosensor chip used for sampling. FIG. 6 is a side view showing a second embodiment of the biosensor puncture device, and FIG. 7 is a perspective view showing an example of a biosensor cartridge. FIG. 8 is a side view showing the biosensor puncture device of FIG. 4 when a biosensor cartridge is used.

  As shown in FIG. 1, a biosensor puncture device 10 according to a first embodiment of the present invention is provided with a biosensor puncture device body 10a and a tip 11a rotatably provided on the biosensor puncture device body 10a. The arm member 11 includes a needle 12 and a rotation mechanism 13 that rotates the arm member 11 with respect to the biosensor puncture device main body 10 a. The rotation mechanism 13 rotates the arm member 11. It is moved to puncture the needle 12 at the puncture position.

  As shown in FIG. 1, a rotation mechanism 13 is attached to one side surface of the biosensor puncture device main body 10 a, and the arm member 11 is rotatably attached to the rotation mechanism 13. The rotation mechanism 13 has a fixed portion fixed to the biosensor puncture device main body 10a and a rotation portion rotatable relative to the fixed portion, and the arm member 11 is fixed to the rotation portion. ing. As shown in FIG. 1, the arm member 11 may be bent on a partial arc, or may be a linear member (see FIG. 4). A puncture needle 12 is provided at the distal end portion 11a of the arm member 11, and is attached so as to puncture substantially perpendicularly when the subject M is punctured (a state indicated by a two-dot chain line in FIG. 1). .

  As a drive source in the rotation mechanism 13, for example, a motor 15 or a spring 16 (indicated by a two-dot chain line in FIG. 1) can be employed. When the spring 16 is used, the arm member 11 is provided to urge the restoring force in the direction of arrow A in a state where the subject M is punctured (state indicated by a two-dot chain line in FIG. 1). A stopper is provided so as to stop at the reference position (the position shown in FIG. 3A) before the subject M is punctured.

  First, FIGS. 2A to 2C show a puncturing operation when the motor 15 is used as a rotation mechanism. First, as shown in FIG. 2A, the needle 12 is lifted and positioned at the puncture position (for example, the subject M), and the motor 15 as the rotation mechanism 13 is rotated counterclockwise to move the arm. The member 11 is rotated downward. Thereby, as shown in FIG. 2 (B), the needle 12 is punctured into the finger F or the like of the subject M. Thereafter, as shown in FIG. 2C, the motor 15 is rotated counterclockwise to lift the arm member 11 and the needle 12 is removed.

  Next, FIGS. 3A to 3D show a puncturing operation when the spring 16 is used as a rotation mechanism. First, as shown in FIG. 3A, a stopper (not shown) is provided for positioning the arm member 11 so that the tip 12a of the needle 12 is positioned at a reference position slightly above the puncture position of the subject M. In this state, the biosensor puncture device 10 is positioned at the puncture position. Then, as shown in FIG. 3B, the arm member 11 is rotated and lifted by the finger F, and the finger F is released. As a result, as shown in FIG. 3C, the arm member 11 is rotated downward by the restoring force of the spring 16 and comes into contact with the stopper to stop the rotation. However, the tip 11a of the arm member 11 is inertial. Is further lowered to puncture the subject M with the needle 12. Thereafter, the tip 11a of the arm member 11 lifts the needle 12 by the spring elastic force and removes it from the subject M, and stops at the reference position.

  As described above, according to the biosensor puncture device 10 according to the present invention, the subject M does not puncture the needle 12 himself, but the rotation mechanism provided in the biosensor puncture device body 10a. 13, the arm member 11 is rotated, and the needle 12 provided at the tip 11a of the arm member 11 is punctured at the puncture position. For this reason, it can puncture without hesitation. Moreover, since the time required for puncture can be shortened, the burden on the subject M can be reduced. Furthermore, when the needle 12 is punctured, the arm member 11 to which the needle is attached abuts against the puncture position of the subject M, so that pain caused by the puncture can be reduced and the burden can be reduced.

Note that the biosensor puncture device of the present invention is not limited to the above-described embodiment, and appropriate modifications and improvements can be made.
For example, in the above-described embodiment, the arm member 11 has a partial arc shape, and the needle 12 is provided on the distal end surface. However, as shown in FIG. You may make it provide the needle | hook 12 in the front-end | tip part lower surface. In this case as well, similar actions and effects can be obtained.

Next, a sample collection method according to the present invention will be described. This sampling method is to sample the sample by positioning the biosensor chip 14 at the puncture position in conjunction with the rotation mechanism 13 of the biosensor puncture device 10 described above.
For example, when the motor 15 is used as the rotation mechanism 13, the biosensor chip 14 is positioned at the puncture position in conjunction with the rotation of the motor 15 shown in FIG. That is, as shown in FIG. 2B, the motor 15 is rotated forward to puncture the puncture position, and then the motor 15 is reversed as shown in FIG. Is positioned at the puncture position, and a sample flowing out from the puncture site is collected. The biosensor chip 14 can also be provided in the biosensor puncture device 10.

Alternatively, when the spring 16 is used as the rotation mechanism 13, for example, as shown in FIG. 3B, when the arm member 11 is lifted by the finger F, the biosensor chip 14 is positioned at the puncture position. Thereafter, as shown in FIG. 3C, the arm member 11 is rotated downward by releasing the finger F, and the subject M is punctured with the needle 12. At this time, as shown in FIG. 5, a biosensor chip 14 having a through hole 14a at a predetermined position and using the hole 14a as a sample introduction port 21 (FIG. 7) is used. Then, the through hole 14a is positioned at the puncture position, and the subject M is punctured through the through hole 14a with the needle 12. Thereafter, as shown in FIG. 3D, when the arm member 11 is lifted and the needle 12 is separated from the subject M, the sample flows out and is collected from the sample introduction port.
In the case where the spring 16 is used, as in the case where the motor 15 is used, the sample can be collected by moving the biosensor chip 14 to the puncture position after removing the needle 12. Also in this case, the biosensor chip 14 can be provided in the biosensor puncture device 10.

  As described above, in the sample collection method according to the present invention, since the biosensor chip 14 is positioned at the puncture position in conjunction with the movement of the arm member 11 by the rotation mechanism 13 of the biosensor puncture device 10, the puncture is performed. The sample that has flowed out can be reliably and quickly collected.

Next, a biosensor puncture device according to a second embodiment of the present invention will be described.
FIG. 6 is an enlarged view of a main part of a biosensor puncture device according to a second embodiment of the present invention, and FIG. 7 is a perspective view showing an example of a biosensor cartridge. In addition, the same code | symbol is attached | subjected to the site | part which is common in 1st Embodiment mentioned above in FIGS. 1-5, and the overlapping description is abbreviate | omitted.

  In the biosensor puncture device 10 </ b> B, a biosensor cartridge 14 </ b> B is used as the needle 12. That is, as shown in FIG. 6, the biosensor cartridge 14B is replaceably attached to the distal end surface of the arm member 11, and puncture is performed with the needle 12 of the biosensor cartridge 14B to collect a sample. In this case, it is desirable that a measuring instrument is provided in the biosensor puncture device body 10a so that the biosensor chip 14B is electrically connected to the measuring instrument via the arm member 11. .

  In the present invention, the biosensor cartridge means a biosensor chip with a needle, and a biosensor cartridge, for example, one having a needle 12 at the tip as shown in FIG. 7 can be used. This biosensor cartridge 14B mainly has a pair of rectangular upper and lower substrates 17a and 17b and a spacer layer 18 between both the substrates 17a and 17b, and a needle 12 projects from the distal end surface. . Between the two substrates 17a and 17b, the spacer layer 18 is cut to form a hollow reaction part (not shown). The front end of the hollow reaction part is opened near the needle 12 and a sample introduction port 21 is provided. ing. A pair of detection electrodes 22a and 22b are provided on the inner surface of one substrate 17a. The detection electrodes 22a and 22b are arranged at a predetermined interval in the hollow reaction part, and a biochemical reaction such as a catalyst and an enzyme with the sample is performed directly above or in the vicinity of the detection electrodes 22a and 22. A reagent (not shown) is provided. The detection electrodes 22a and 22b protrude from the rear end and are exposed, and can be electrically connected to the connection terminal on the arm member 11 side.

  When such a biosensor cartridge 14B is used, immediately after the needle 12 is separated from the finger F of the subject M in FIG. 2 (B), the sample is immediately taken from the sample introduction port 21 provided at the tip of the biosensor chip 14. Can be collected. The collected sample is introduced into the hollow reaction unit 19 to react with the reagent, and information obtained from this reaction is transmitted to the measuring instrument in the biosensor puncture device body 10a via the detection electrodes 22a and 22b. Predetermined measurement.

  The needle 12 can also be formed of a biodegradable material such as polylactic acid or maltose. In this case, the sample can be collected in the puncture state shown in FIG. Also, even if the needle 12 is broken and a part remains in the body at the time of puncturing, the needle is decomposed and melts in the body, so that it is not necessary to forcibly collect the broken needle, and the burden on the subject M Can be reduced.

  Further, as shown in FIG. 8, when the linear arm member 11 described above in FIG. 4 is used, a biosensor chip 14C in which a needle 12 is provided downward on the lower surface of the distal end portion of the arm member 11 is used. Like that.

  As described above, the biosensor puncture device according to the present invention can be punctured by the puncture member without wrinkling. Moreover, since the time required for puncture can be shortened, the burden on the subject can be reduced.

It is a side view which shows 1st Embodiment which concerns on the puncture device for biosensors of this invention. (A)-(C) are side views which show each process of the puncture operation | movement at the time of using a motor as a rotation mechanism. (A)-(D) are side views which show each process of puncture operation | movement at the time of using a spring as a rotation mechanism. It is a side view which shows another example of the puncture device for biosensors concerning this invention. It is a top view which shows an example of the biosensor chip used for collection of a sample. It is a side view which shows the biosensor puncture device at the time of using the needle | hook of a biosensor cartridge as a needle | hook. It is a perspective view which shows an example of a biosensor cartridge. FIG. 5 is a side view showing the biosensor puncture device of FIG. 4 when a needle of a biosensor cartridge is used as the needle. It is sectional drawing which shows the conventional puncture device for biosensors.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Biosensor puncture device 10a Biosensor puncture device main body 11 Arm member 11a Tip 12 Needle 13 Rotating mechanism 14 Biosensor chip 14B Biosensor cartridge 15 Motor 16 Spring

Claims (9)

  A biosensor puncture device comprising: an arm portion provided with a puncture member; and a turning portion provided with a turning mechanism for turning the arm portion.   The biosensor puncture device according to claim 1, wherein the pivot mechanism rotates the arm portion to puncture the puncture member at a puncture position.   The biosensor puncture device according to claim 1 or 2, wherein the rotation mechanism includes a motor.   The biosensor puncture device according to claim 1 or 2, wherein the rotation mechanism includes a spring.   The biosensor puncture device according to any one of claims 1 to 4, wherein the puncture member is a needle.   6. The biosensor puncture device according to claim 5, wherein the needle and the biosensor chip are separately provided.   6. The biosensor puncture device according to claim 5, wherein the puncture member is a biosensor cartridge.   A sample collection method comprising: collecting a sample by positioning a biosensor chip at a puncture position in conjunction with a rotation mechanism of the puncture member. A biosensor device comprising the biosensor puncture device according to claim 1.

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