JP2007505824A5 - - Google Patents
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- Publication number
- JP2007505824A5 JP2007505824A5 JP2006525790A JP2006525790A JP2007505824A5 JP 2007505824 A5 JP2007505824 A5 JP 2007505824A5 JP 2006525790 A JP2006525790 A JP 2006525790A JP 2006525790 A JP2006525790 A JP 2006525790A JP 2007505824 A5 JP2007505824 A5 JP 2007505824A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- sequence
- polypeptide
- acid molecule
- cell division
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims description 56
- 108020004707 nucleic acids Proteins 0.000 claims description 50
- 102000039446 nucleic acids Human genes 0.000 claims description 50
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 37
- 229920001184 polypeptide Polymers 0.000 claims description 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 26
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 22
- 102000029749 Microtubule Human genes 0.000 claims description 19
- 108091022875 Microtubule Proteins 0.000 claims description 19
- 230000032823 cell division Effects 0.000 claims description 19
- 210000004688 microtubule Anatomy 0.000 claims description 19
- 230000020347 spindle assembly Effects 0.000 claims description 19
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
- 230000000692 anti-sense effect Effects 0.000 claims description 8
- 239000013604 expression vector Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 108020005544 Antisense RNA Proteins 0.000 claims description 5
- 108020004459 Small interfering RNA Proteins 0.000 claims description 5
- 239000003184 complementary RNA Substances 0.000 claims description 5
- 230000014509 gene expression Effects 0.000 claims description 5
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 3
- 238000002372 labelling Methods 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 230000003213 activating effect Effects 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 239000012190 activator Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 238000012512 characterization method Methods 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 201000000054 Coronary Restenosis Diseases 0.000 claims 2
- 206010056489 Coronary artery restenosis Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 239000000061 acid fraction Substances 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 239000008196 pharmacological composition Substances 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 238000007423 screening assay Methods 0.000 claims 2
- 239000007790 solid phase Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 208000012766 Growth delay Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 238000002825 functional assay Methods 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 238000009396 hybridization Methods 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 241000972773 Aulopiformes Species 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 108091027967 Small hairpin RNA Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50263303P | 2003-09-15 | 2003-09-15 | |
| PCT/EP2004/010307 WO2005026359A2 (en) | 2003-09-15 | 2004-09-15 | The use of eukaryotic genes affecting spindle formation or microtubule function during cell division for diagnosis and treatment of proliferative diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007505824A JP2007505824A (ja) | 2007-03-15 |
| JP2007505824A5 true JP2007505824A5 (cg-RX-API-DMAC7.html) | 2007-11-08 |
Family
ID=34312410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525790A Pending JP2007505824A (ja) | 2003-09-15 | 2004-09-15 | 増殖性疾患の診断および治療における、細胞分裂の間のスピンドル形成または微小管機能に影響を与える真核生物遺伝子の利用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7479369B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1682663A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2007505824A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004272737A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2538461A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005026359A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE533358T1 (de) * | 2005-09-16 | 2011-12-15 | Devgen Nv | Verfahren zum kontrollieren von schädlingen mittels rnai |
| CA2622660C (en) * | 2005-09-16 | 2017-11-07 | Devgen Nv | Transgenic plant-based methods for plant pests using rnai |
| US20080295196A1 (en) | 2006-12-06 | 2008-11-27 | Abad Mark S | Genes and uses for plant improvement |
| WO2016007747A1 (en) * | 2014-07-09 | 2016-01-14 | Cleave Biosciences, Inc. | Drug-resistant p97 atpase mutations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1041147A2 (en) | 1999-04-01 | 2000-10-04 | Europäisches Laboratorium Für Molekularbiologie (Embl) | Microtubule-associated protein TPX2 |
| WO2004074441A2 (en) * | 2003-02-19 | 2004-09-02 | Government Of The United States Of America Represented By The Secretary Department Of Health And Human Services | Amplification or overexpression of mll septin-like fusion (msf) and septin9 and methods related thereto |
-
2004
- 2004-09-15 US US10/572,004 patent/US7479369B2/en not_active Expired - Fee Related
- 2004-09-15 EP EP04765221A patent/EP1682663A2/en not_active Withdrawn
- 2004-09-15 WO PCT/EP2004/010307 patent/WO2005026359A2/en not_active Ceased
- 2004-09-15 CA CA002538461A patent/CA2538461A1/en not_active Abandoned
- 2004-09-15 AU AU2004272737A patent/AU2004272737A1/en not_active Abandoned
- 2004-09-15 JP JP2006525790A patent/JP2007505824A/ja active Pending
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