JP2007326815A - Method for producing condensed polycyclic compound - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method by which anthraquinone derivatives having low reactivity are mutually and directly subjected to ring condensation by dimerization and a polycyclic compound can stereoselectively be mass-produced in good yield. <P>SOLUTION: The method for producing the condensed polycyclic compound is carried out as follows. Anthraquinones in which the 1-, 2-, 7- and 8-positions may be unsubstituted and the 3- and 6-positions are substituted with a free hydroxy group or substituted with a hydroxy group protected by a protecting group with the unsubstituted 4- and 5-positions are exposed to high pressure of 1×10<SP>8</SP>to 1×10<SP>10</SP>Pa. Two molecules thereof are mutually bound with carbon atoms at the 10-position and carbon atoms of either one of the 4- and 5-positions to provide a dimer. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a method for producing a polycyclic compound by ring condensation of anthraquinones under high pressure.

  Among naturally occurring condensed polycyclic compounds, those which are in vivo pigments, physiologically active substances having antibacterial and antiviral effects, and organic dyes are known.

  Stentorin-C described in Non-Patent Document 1 was isolated as a photoreceptor dye from Stentor coeruleus and is a condensed polycyclic compound having a phenanthropyrene dione skeleton. Have anti-human immunodeficiency virus (anti-HIV) activity. Stentrin C has already been fully synthesized.

  For example, in Non-Patent Documents 1 and 2, as shown by the following chemical reaction formula [1], anthrone derivative (11) in which anthraquinone derivative (10) is reduced is dimerized by coupling at the methylene site, After induction into a 1: 1 diastereomeric mixture (12) of meso and dl forms, heating in an oxygen atmosphere and irradiation with ultraviolet (UV) light to oxidative photocyclization, followed by deprotection Synthetic methods leading to C (2) are disclosed.

  In Non-Patent Document 3, as shown in the following chemical reaction formula [2], anthrone derivative (11) is oxidatively dimerized and subsequently oxidatively photocyclized to give Stentrin C (2) and its isomer. A synthetic method is disclosed that leads to a 1: 1 mixture with certain Isostentorin-C (3).

Both methods have a problem that the stereoselectivity in the dimerization between the molecules of the anthrone derivative (11, 13) is low and it is difficult to separate and purify the desired stentrin C (2).
In Non-Patent Document 4, as shown by the following chemical reaction formula [3], the anthraquinone derivative (14) is converted to a derivative (15) obtained by dimerization by Ullmann coupling reaction, followed by a reductive molecule. A synthetic method is disclosed that undergoes internal cyclization, followed by oxidative photocyclization, followed by deprotection, leading to Stentrin C (2). This method has a problem that the yield in intramolecular cyclization / oxidative photocyclization is extremely low.

  There is no known method for direct dimerization of anthraquinone derivatives having low reactivity to each other to induce Stentrin C (2) in a stereoselective manner with a high yield.

  On the other hand, in Patent Document 1, a thiophene derivative obtained by crosslinking thiophene that does not act as a diene under normal pressure and maleic anhydride without solvent in a high pressure condition of 100 to 2000 MPa by a Diels-Alder reaction. A method for synthesizing is described.

Di. W. Cameron and A. Gee. Riches (D.W.Cameron and A.G.Riches), `` Tetrahedron Letters '', 1995, Vol. 36, p.2331 Di. W. Cameron and A. Gee. Riches (D.W.Cameron and A.G.Riches), "Australian Journal of Chemistry", 1997, 50, p. 409 H. Volk and E. H. Falk and E. Mayr, “Monatshefte fuer Chemie”, 1995, 126, p. 1311 H. Iio, K. Zenfuku, and T. Tokoroyama, Tetrahedron Letters, 1995, Vol. 36, p. 5921 JP 2003-192688 A

  The present invention has been made to solve the above-mentioned problems, and anthraquinone derivatives having low reactivity are directly subjected to ring condensation by dimerization to provide a stereoselective yield and a large amount of polycyclic compounds. An object is to provide a method that can be manufactured.

In the method for producing a condensed polycyclic compound according to claim 1, the first, second, seventh, and eighth positions may be unsubstituted, and the third and sixth positions may be substituted. Is exposed to a high pressure of 1 × 10 ⁸ to 1 × 10 ¹⁰ Pa, and the two molecules are exposed to an anthraquinone substituted with a free hydroxyl group or with a hydroxyl group protected by a protecting group and unsubstituted at positions 4 and 5; It is characterized in that the carbon atom at the 10th position is bonded to any one of the carbon atoms at the 4th and 5th positions to form a dimer.

  The method for producing a condensed polycyclic compound according to claim 2 is the method according to claim 1, wherein the dimer is irradiated with light, and the other carbon atom at the 4,5-position of the anthraquinones. It is characterized by bonding them to phenanthropyrenediones.

  The method for producing a condensed polycyclic compound according to claim 3 is the method according to claim 2, wherein at least one of the 3,6 positions of the anthraquinones is substituted with a hydroxyl group protected by the protecting group. And the cleaving group is cleaved from the phenanthropyrene diones.

  The method for producing a condensed polycyclic compound according to claim 4 is the method according to any one of claims 1 to 3, wherein one of the 3,6 positions of the anthraquinones is substituted with the free hydroxyl group. Is substituted with a hydroxyl group protected by the protecting group selected from an alkyl group, an aralkyl group and an acyl group, and the 1,8-position is also substituted with a free hydroxyl group, or a protection selected from an alkyl group, an aralkyl group and an acyl group It is substituted with a hydroxyl group protected by a group, and at least one of the 2,7 positions is also substituted with an alkyl group.

  The method for producing a condensed polycyclic compound according to claim 5 is the method according to claim 4, wherein the anthraquinones are represented by the following chemical formula (1):

(In the chemical formula (1), R is the protecting group), which is exposed to the high pressure under alkaline conditions to form the dimer, and then irradiated with light to form the phenanthropyrene dione. Then, the protecting group is cleaved under acidic conditions to obtain the following chemical formula (2)

It is characterized by making it the stentrin C represented by these.

  The method for producing anthraquinones according to claim 6 comprises the step of reacting a 3,4,5-trialkoxybenzoate with an alkylmagnesium halide or alkenylmagnesium halide, and then reducing 4-alkyl or alkenyl-3, After reacting 5-dialkoxybenzaldehyde with the ortho-thiothiol of 2-alkoxy-4-trialkylsiloxybenzoic acid N, N-dialkylamide, lactonization reaction under acidic conditions, catalytic reduction reaction, intramolecular The reaction is performed in the order of Friedel-Crafts reaction, oxidation reaction and alkoxy cleavage reaction.

  According to the method for producing a condensed polycyclic compound of the present invention, a dimer of anthraquinones having low reactivity is directly subjected to ring condensation by dimerization under high pressure, whereby the polycyclic compound is easily and efficiently obtained. Can be manufactured in large quantities. Moreover, a polycyclic compound can be produced stereoselectively by appropriately selecting a substituent of anthraquinones.

  Examples of the method for producing a condensed polycyclic compound of the present invention will be described in detail below, but the scope of the present invention is not limited to these examples.

  A preferred embodiment of a method for producing a condensed polycyclic compound from anthraquinones will be described with reference to the chemical reaction formula [4].

  First, anthraquinones are synthesized as follows.

The starting material is an ester (21) derived from 3,4,5-trialkoxybenzoic acid (20). In this benzoic acid ester (21), R ¹ O—, R ² O—, and R ³ O— are C 1-6 alkoxy groups such as a methoxy group and aralkyloxy groups such as a benzyloxy group. . R ⁴ is a linear or branched alkyl group having 1 to 10 carbon atoms.

Aromatic nucleophilic substitution (S) with 3,4,5-trialkoxybenzoate (21) using a Grignard reagent such as alkyl magnesium halide or alkenyl magnesium halide (R ⁵ MgX) having 1 to 6 carbon atoms. _The alkyl group R ⁵ is introduced by the _N Ar) reaction. Subsequently, through reduction with lithium aluminum hydride and subsequent oxidation with pyridinium chlorochromate (PCC) or active manganese dioxide, the ester group is reduced to an aldehyde group, and 4-isopropyl-3,5-dialkoxybenzaldehyde (22) And

Another starting material is an ortho trithio (23) obtained by lithiation of 2-alkoxy-4-trialkylsiloxybenzoic acid N, N-dialkylamide with n-butyllithium (n-BuLi). In this ortho trithio (23), R ⁶ O— is a C 1-6 alkoxy group such as a methoxy group, R ⁷ — is a C 1-6 alkyl group such as an ethyl group, ^8- , R ^9- , and R ¹⁰ -are the same or different alkyl groups having 1 to 6 carbon atoms.

  After reacting 4-isopropyl-3,5-dialkoxybenzaldehyde (22) with the ortho-thio compound (23) of 2-alkoxy-4-trialkylsiloxybenzoic acid N, N-dialkylamide, p-toluene When lactonized under acidic conditions such as in the presence of sulfonic acid (p-TosOH), lactone (24) is obtained.

This lactone (24) is subjected to a catalytic reduction reaction in the presence of a catalyst such as palladium hydroxide-carbon (Pd (OH) ₂ / C), followed by intramolecular free in the presence of an acid anhydride such as trifluoroacetic anhydride. Anthraquinones (25) corresponding to the chemical formula (1) can be obtained by reacting in the order of Friedel-Crafts reaction, air oxidation reaction, and alkoxy cleavage reaction in the presence of aluminum chloride. In addition, the substitution position of anthraquinones (25) is indicated by a numeral.

  The anthraquinones (25) may be substituted with the aforementioned alkoxy group or aralkyloxy group, and may be substituted with an acyl group such as an acetyl group or a benzoyl group.

  A condensed polycyclic compound is synthesized from the anthraquinones (25) as follows.

The anthraquinones (25) are 1 × 10 ⁸ to 1 × 10 ¹⁰ Pa under alkaline conditions such as in an aqueous hydroxide solution in the presence of hydroquinone as a polymerization inhibitor, preferably 0.8 to When exposed to a high pressure of 1.5 GPa, more preferably 0.8 GPa with heating, two molecules of anthraquinones (25) are bonded to each other at the 10-position carbon atoms and the 5-position carbon atoms. A symmetrical dimer (26) is obtained stereoselectively. If the pressure is lower than this range, the reaction does not proceed. On the other hand, if the pressure is higher than this range, the product is decomposed or tarred.

  The anthraquinones (25) are preferably exposed to high pressure while being heated to 150 ° C. for several hours to one week, preferably for one day. It is preferable to use 3 equivalents of hydroquinone. The alkaline condition is preferably in a 0.6N potassium hydroxide aqueous solution.

  When the dimer (26) is irradiated with light such as sunlight, the 4-position carbon atoms of the anthraquinones (25) are bonded to each other to form the compound (26) having a phenanthropyrene dione skeleton. If necessary, when the alkoxy group at the 3-position is converted to a hydroxyl group by an alkoxy cleavage agent such as hydroiodic acid, phenanthropyrene diones corresponding to Stentrin C of the above chemical formula (2) and derivatives thereof (27) Is obtained.

  A point-symmetric dimer which is an isomer of this plane-symmetric phenanthropyrenedione (27) cannot be obtained. Although the details are not necessarily clear, when dimerization, an alkoxy group is substituted at the 3-position of the anthraquinones (25) and a hydroxyl group is substituted at the 6-position. It is presumed that this caused a difference and the 5-positions of anthraquinones (25) reacted selectively due to the difference in electron density.

  Hereinafter, examples in which Stentrin C, which is an example of a condensed polycyclic compound, was produced by using a commercially available reagent as a raw material by the method for producing a condensed polycyclic compound of the present invention will be described below.

激しく撹拌させている無水硫酸マグネシウム（２２０ｇ，１．８３ｍｏｌ）の１２００ｍＬ無水クロロホルム懸濁液に、濃硫酸（２５．２ｍＬ，４５８ｍｍｏｌ）を加えた。それに３,４,５-トリメトキシ安息香酸(30)（９７ｇ，４５８ｍｍｏｌ）を加えた後、その混合物を１５分間撹拌した。次いでtert-ブタノール（t-ＢｕＯＨ）（２１８ｍＬ，２．２９ｍｏｌ）を加えた。この混合物を、密栓下、室温で１２時間撹拌した。その反応混合物に飽和炭酸水素ナトリウム水溶液を加え、反応を止めた後、硫酸マグネシウムが完全に溶解するまで撹拌した。有機層を、分液し、飽和食塩水で洗浄し、無水硫酸マグネシウムで乾燥させた。有機溶媒を減圧下で留去すると、無色固体の３,４,５−トリメトキシ安息香酸tert-ブチル(31a)（１２０ｇ，収率９８％）が得られた。その安息香酸ブチル体(31a)の薄層クロマトグラフィーによるR_f値の物性と、フーリエ変換赤外分光光度法（FTIR）、¹H及び¹³C 核磁気共鳴スペクトル測定法（NMR）による分光学的データとを示す。
R_f 0.28 (展開溶媒 ヘキサン/酢酸エチル = 4:1).
FTIR (KBr) ν1704, 1586, 1337, 1124 cm^-1.
¹H NMR (400 MHz, CDCl₃) δ 1.60 (9H, s), 3.90 (3H, s), 3.91 (6H, s), 7.26 (2H, s).
¹³C NMR (100 MHz, CDCl₃) δ 28.1 (×3), 56.1 (×3), 60.8, 81.1, 106.6 (×2), 127.0, 141.8, 152.7 (×2), 165.3. (Synthesis of tert-butyl 3,4,5-trimethoxybenzoate (31a))

Concentrated sulfuric acid (25.2 mL, 458 mmol) was added to a 1200 mL anhydrous chloroform suspension of anhydrous magnesium sulfate (220 g, 1.83 mol) that was vigorously stirred. To it was added 3,4,5-trimethoxybenzoic acid (30) (97 g, 458 mmol) and the mixture was stirred for 15 minutes. Then tert-butanol (t-BuOH) (218 mL, 2.29 mol) was added. The mixture was stirred for 12 hours at room temperature under a tight stopper. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture to stop the reaction, and the mixture was stirred until magnesium sulfate was completely dissolved. The organic layer was separated, washed with saturated brine, and dried over anhydrous magnesium sulfate. The organic solvent was distilled off under reduced pressure to obtain colorless solid tert-butyl 3,31,5-trimethoxybenzoate (31a) (120 g, yield 98%). Physical properties of _Rf value of the butyl benzoate (31a) by thin layer chromatography and spectroscopic analysis by Fourier transform infrared spectrophotometry (FTIR), ¹ H and ¹³ C nuclear magnetic resonance spectroscopy (NMR) Data.
R _f 0.28 (developing solvent hexane / ethyl acetate = 4: 1).
FTIR (KBr) ν1704, 1586, 1337, 1124 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ 1.60 (9H, s), 3.90 (3H, s), 3.91 (6H, s), 7.26 (2H, s).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 28.1 (× 3), 56.1 (× 3), 60.8, 81.1, 106.6 (× 2), 127.0, 141.8, 152.7 (× 2), 165.3.

撹拌している安息香酸ブチル体(31a)（６５ｇ，２４２ｍｍｏｌ）の６００ｍＬトルエン溶液に、−１５℃で、１．０Ｎのイソプロピルマグネシウムクロリドのジエチルエーテル溶液（４８５ｍＬ，４８５ｍｍｏｌ）を加えた。その混合物を５時間撹拌した。反応混合物に氷水と２Ｎ塩酸とを加え反応を止めた。有機相を分液し、飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥させた。有機溶媒を留去した後、油状粗生成物をシリカゲルカラムクロマトグラフィーにより精製すると、無色固体の４-イソプロピル-３,５-ジメトキシ安息香酸tert-ブチル(32a)（３７ｇ，収率５５％）が得られた。その４-イソプロピル-安息香酸ブチル体(32a)物性と分光学的データとを示す。
R_f 0.40 (展開溶媒 ヘキサン/酢酸エチル = 9:1).
融点 65.0-65.5 ℃.
FTIR (KBr) ν 1710, 1579, 1144 cm^-1.
¹H NMR (400 MHz, CDCl₃) δ 1.27 (6H, d, J = 7.1 Hz), 1.59 (9H, s), 3.62 (1H, sept, J = 7.1 Hz), 3.84 (6H, s), 7.18 (2H, s).
¹³C NMR (100 MHz, CDCl₃) δ 20.3 (×2), 24.3, 28.2 (×3), 55.7, 80.9, 105.4, 129.4, 130.3, 158.2 (×2), 165.8. (Synthesis of tert-butyl 4-isopropyl-3,5-dimethoxybenzoate (32a))

To a 600 mL toluene solution of the stirred butyl benzoate (31a) (65 g, 242 mmol) at −15 ° C., 1.0 N isopropylmagnesium chloride in diethyl ether (485 mL, 485 mmol) was added. The mixture was stirred for 5 hours. Ice water and 2N hydrochloric acid were added to the reaction mixture to stop the reaction. The organic phase was separated, washed with saturated brine, and dried over anhydrous sodium sulfate. After the organic solvent was distilled off, the oily crude product was purified by silica gel column chromatography to obtain colorless solid tert-butyl 4-isopropyl-3,5-dimethoxybenzoate (32a) (37 g, yield 55%). Obtained. The physical properties and spectroscopic data of the 4-isopropyl-butyl benzoate (32a) are shown.
R _f 0.40 (developing solvent hexane / ethyl acetate = 9: 1).
Melting point 65.0-65.5 ℃.
FTIR (KBr) ν 1710, 1579, 1144 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ 1.27 (6H, d, J = 7.1 Hz), 1.59 (9H, s), 3.62 (1H, sept, J = 7.1 Hz), 3.84 (6H, s), 7.18 (2H, s).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 20.3 (× 2), 24.3, 28.2 (× 3), 55.7, 80.9, 105.4, 129.4, 130.3, 158.2 (× 2), 165.8.

撹拌しているＬｉＡｌＨ_４（５４１ｍｇ，１４ｍｍｏｌ）の１５ｍＬ無水テトラヒドロフラン懸濁液に、４-イソプロピル-安息香酸ブチル体(32a)（３．５６ｇ，１２．７ｍｍｏｌ）の２０ｍＬ無水テトラヒドロフラン溶液を、０℃で加えた。混合物を、室温で８時間撹拌した。その反応混合物に、０℃で水を加え、反応を止めた。反応混合液を、セライトで濾過した。有機溶媒を減圧下で留去すると、無色固体の４-イソプロピル-３,５-ジメトキシベンジルアルコール（２．６５ｇ，収率９９％）が得られた。このアルコールを精製することなく次の反応に用いた。それの物性を示す。
R_f 0.26 (展開溶媒 ヘキサン/酢酸エチル = 2:1). (Synthesis of 4-isopropyl-3,5-dimethoxybenzaldehyde (33))

To a stirred suspension of LiAlH ₄ (541 mg, 14 mmol) in 15 mL anhydrous tetrahydrofuran, a 20 mL anhydrous tetrahydrofuran solution of 4-isopropyl-butyl benzoate (32a) (3.56 g, 12.7 mmol) was added at 0 ° C. added. The mixture was stirred at room temperature for 8 hours. Water was added to the reaction mixture at 0 ° C. to stop the reaction. The reaction mixture was filtered through celite. The organic solvent was distilled off under reduced pressure to obtain 4-isopropyl-3,5-dimethoxybenzyl alcohol (2.65 g, yield 99%) as a colorless solid. This alcohol was used in the next reaction without purification. Shows its physical properties.
R _f 0.26 (developing solvent hexane / ethyl acetate = 2: 1).

To a suspension of pyridinium chlorochromate (PCC reagent) (3.1 g, 14.4 mmol), sodium acetate (3.0 g, 34 mmol) and celite (300 mg) in anhydrous methylene chloride at 0 ° C., 4-isopropyl A 15 mL methylene chloride solution of −3,5-dimethoxybenzyl alcohol (2.53 g, 12 mmol) was added dropwise. The reaction mixture was stirred for 10 hours and then filtered through florisil. The filtrate was concentrated and purified by silica gel column chromatography to give 4-isopropyl-3,5-dimethoxybenzaldehyde (33) (2.22 g, 89% yield) as a colorless solid. The physical properties and spectroscopic data of the benzaldehyde compound (33) are shown.
R _f 0.65 (developing solvent hexane / ethyl acetate = 2: 1).
FTIR (KBr) ν 1694, 1142 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ 1.29 (6H, d, J = 7.1 Hz), 3.66 (1H, sept, J = 7.1 Hz), 3.87 (6H, s), 7.05 (2H, s), 9.89 (1H, s).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 20.1 (× 2), 24.5, 55.8 (× 2), 105.4 (× 2), 131.8, 135.1, 158.90 (× 2), 191.8.

３,４,５-トリメトキシ安息香酸(30)（５．３ｇ，２５ｍｍｏｌ）の１００ｍＬ塩化メチレン溶液に、触媒量のＮ，Ｎ-ジメチルホルムアミド（cat.ＤＭＦ）と塩化チオニル（２．６６ｍＬ，３７ｍｍｏｌ）とを室温で滴下しながら加えた。反応混合物を一晩、撹拌しながら還流させた。室温まで冷却した後、有機溶媒と過剰の塩化チオニルとを留去し、安息香酸クロリド体を得た。３-エチル-３-ペンタノール（(Ｅｔ)_３ＣＯＨ）（５．３ｍＬ，３７ｍｍｏｌ）の６５ｍＬテトラヒドロフラン溶液に、１．５４Ｎのn-ブチルリチウム（n-ＢｕＬｉ）のヘキサン溶液（１９ｍＬ，３０ｍｍｏｌ）を、滴下しながら加えた。混合物を、室温で１時間撹拌した。この溶液に、先の安息香酸クロリド体の１５ｍＬのテトラヒドロフラン溶液を加えた。混合物を、室温で一晩撹拌した。この反応混合物に水を加え反応を止めた。水相を酢酸エチルで抽出した。有機相を合わせ、飽和食塩水で洗浄し、無水硫酸ナトリウムで乾燥させた。溶媒を留去した後、粗生成物を、シリカゲルカラムクロマトグラフィーにより精製すると、淡黄色油状物の３,４,５-トリメトキシ安息香酸１,１-ジエチルプロピル(31b)（定量的収率）が得られた。その安息香酸ジエチルプロピル体(31b)の物性と分光学的データとを示す。
R_f 0.46 (展開溶媒 ヘキサン/酢酸エチル = 4:1).
FTIR (neat) ν 1705, 1231, 1130 cm^-1.
¹H NMR (400 MHz, CDCl₃) δ 0.89 (9H, t, J = 7.4 Hz), 1.98 (6H, q, J = 7.5 Hz), 3.90 (3H, s), 3.90 (6H, s), 7.27 (2H, s).
¹³C NMR (100 MHz, CDCl₃) δ 7.8 (×3), 27.0 (×3), 56.1 (×3), 60.9, 89.1, 106.6 (×2), 127.0, 141.9, 152.8 (×2), 165.0. (Synthesis of 1,1-diethylpropyl (31b) of 3,4,5-trimethoxybenzoic acid)

To a 100 mL methylene chloride solution of 3,4,5-trimethoxybenzoic acid (30) (5.3 g, 25 mmol), a catalytic amount of N, N-dimethylformamide (cat.DMF) and thionyl chloride (2.66 mL, 37 mmol). Were added dropwise at room temperature. The reaction mixture was refluxed overnight with stirring. After cooling to room temperature, the organic solvent and excess thionyl chloride were distilled off to obtain a benzoic acid chloride. To a 65 mL tetrahydrofuran solution of 3-ethyl-3-pentanol ((Et) ₃ COH) (5.3 mL, 37 mmol), a hexane solution (19 mL, 30 mmol) of 1.54N n-butyllithium (n-BuLi) was added. , Added dropwise. The mixture was stirred at room temperature for 1 hour. To this solution, a 15 mL tetrahydrofuran solution of the benzoic acid chloride was added. The mixture was stirred at room temperature overnight. Water was added to the reaction mixture to stop the reaction. The aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, and dried over anhydrous sodium sulfate. After distilling off the solvent, the crude product was purified by silica gel column chromatography to obtain 1,1-diethylpropyl (31b) (quantitative yield) of 3,4,5-trimethoxybenzoic acid as a pale yellow oil. Obtained. The physical properties and spectroscopic data of the diethylpropyl benzoate (31b) are shown.
R _f 0.46 (developing solvent hexane / ethyl acetate = 4: 1).
FTIR (neat) ν 1705, 1231, 1130 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ 0.89 (9H, t, J = 7.4 Hz), 1.98 (6H, q, J = 7.5 Hz), 3.90 (3H, s), 3.90 (6H, s), 7.27 (2H, s).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 7.8 (× 3), 27.0 (× 3), 56.1 (× 3), 60.9, 89.1, 106.6 (× 2), 127.0, 141.9, 152.8 (× 2), 165.0 .

安息香酸ジエチルプロピル体(31b)（１５５ｍｇ，０．５０ｍｍｏｌ）の２ｍＬトルエン溶液に、０℃で撹拌しながら、０．９８Ｍのイソプロピルマグネシウムクロリドのジエチルエーテル溶液（１．９４ｍＬ，１．９ｍｍｏｌ）を加えた。この混合液を室温で７時間撹拌した。反応混合物に氷水と２Ｎ塩酸とを加え反応を止めた。有機相を分液し、飽和食塩水で洗浄後、無水硫酸ナトリウムで乾燥させた。溶媒を留去した後、粗生成物を分取薄層クロマトグラフィー（展開溶媒 ヘキサン／アセトン ＝ ４：１）により精製すると、無色固体の４-イソプロピル-３,５-ジメトキシ安息香酸１,１-ジエチルプロピル(32b)（１２６ｍｇ，収率７８％）が得られた。その安息香酸ジエチルプロピル体(32b)の物性と分光学的データとを示す。
R_f 0.63 (展開溶媒 ヘキサン/酢酸エチル = 9:1).
融点 65.0-65.5 ℃
¹H NMR (400 MHz, CDCl₃) δ 1.27 (6H, d, J = 7.1 Hz), 1.59 (9H, s), 3.62 (1H, quin, J = 7.1 Hz), 3.84 (6H, s), 7.18 (2H, s).
¹³C NMR (100 MHz, CDCl₃) δ 20.3 (×2), 24.3, 28.2 (×3), 55.7 (×2), 80.9, 105.4, 129.4, 130.3, 158.2 (×2), 165.79. (Synthesis of 4-Isopropyl-3,5-dimethoxybenzoic acid 1,1-diethylpropyl (32b))

To a 2 mL toluene solution of diethylpropyl benzoate (31b) (155 mg, 0.50 mmol), 0.98 M isopropylmagnesium chloride in diethyl ether (1.94 mL, 1.9 mmol) was added with stirring at 0 ° C. It was. The mixture was stirred at room temperature for 7 hours. Ice water and 2N hydrochloric acid were added to the reaction mixture to stop the reaction. The organic phase was separated, washed with saturated brine, and dried over anhydrous sodium sulfate. After the solvent was distilled off, the crude product was purified by preparative thin layer chromatography (developing solvent hexane / acetone = 4: 1) to give colorless solid 4-isopropyl-3,5-dimethoxybenzoic acid 1,1- Diethylpropyl (32b) (126 mg, 78% yield) was obtained. The physical properties and spectroscopic data of the diethylpropyl benzoate (32b) are shown.
R _f 0.63 (developing solvent hexane / ethyl acetate = 9: 1).
Melting point 65.0-65.5 ℃
¹ H NMR (400 MHz, CDCl ₃ ) δ 1.27 (6H, d, J = 7.1 Hz), 1.59 (9H, s), 3.62 (1H, quin, J = 7.1 Hz), 3.84 (6H, s), 7.18 (2H, s).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 20.3 (× 2), 24.3, 28.2 (× 3), 55.7 (× 2), 80.9, 105.4, 129.4, 130.3, 158.2 (× 2), 165.79.

(Synthesis of 4-isopropyl-3,5-dimethoxybenzaldehyde (33))
Similar to the synthesis of benzaldehyde (33) from butyl benzoate (31a) through (32a) as described above, benzaldehyde (33) was obtained from diethylpropyl benzoate (32b) in the same yield. Was synthesized.

  The overall yield in the method of synthesizing the benzaldehyde form (33) from the benzoic acid form (30) via the butyl benzoate form (31a, 32a) was 46%, and the butyl benzoate form (31a) was obtained. Since it is easy, benzaldehyde (33) can be synthesized on a scale of 50 g or more. On the other hand, the yield is good because the total yield in the method of synthesizing the benzaldehyde body (33) from the benzoic acid body (30) through the diethylpropyl benzoate body (31b, 32b) is about 70%.

２,４-ジヒドロキシ安息香酸(34)（２５ｇ，１６２ｍｍｏｌ）の２００ｍＬ無水メタノール溶液に、０℃で撹拌しながら、塩化チオニル（２８ｍＬ，２４３ｍｍｏｌ）を加えた。混合物を撹拌しながら、３０分間還した。有機溶媒を減圧下で留去すると、定量的に２,４-ジヒドロキシ安息香酸メチル(35)が得られた。さらに再結晶により精製して、無色固体の純粋な安息香酸メチル体(35)を得た。それの物性と分光学的データとを示す。
R_f 0.49 (展開溶媒 ヘキサン/酢酸エチル = 1:1).
FTIR (KBr) ν 3341, 1642 cm^-1.
¹H NMR (400 MHz, CDCl₃) δ 3.92 (3H, s), 6.37 (1H, d, J = 2.4 Hz), 6.40 (1H, dd, J = 2.4, 6.8 Hz), 7.73 (1H, d, J = 8.8 Hz), 11.0 (1H, br).
¹³C NMR (100 MHz, CDCl₃) δ 52.0, 103.0, 105.7, 108.0, 131.9, 162.3, 163.4, 170.4. (Synthesis of methyl 2,4-dihydroxybenzoate (35))

Thionyl chloride (28 mL, 243 mmol) was added to a 200 mL anhydrous methanol solution of 2,4-dihydroxybenzoic acid (34) (25 g, 162 mmol) with stirring at 0 ° C. The mixture was returned for 30 minutes with stirring. When the organic solvent was distilled off under reduced pressure, methyl 2,4-dihydroxybenzoate (35) was quantitatively obtained. Further purification by recrystallization gave a pure methyl benzoate (35) as a colorless solid. Its physical properties and spectroscopic data are shown.
R _f 0.49 (developing solvent hexane / ethyl acetate = 1: 1).
FTIR (KBr) ν 3341, 1642 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ 3.92 (3H, s), 6.37 (1H, d, J = 2.4 Hz), 6.40 (1H, dd, J = 2.4, 6.8 Hz), 7.73 (1H, d, J = 8.8 Hz), 11.0 (1H, br).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 52.0, 103.0, 105.7, 108.0, 131.9, 162.3, 163.4, 170.4.

安息香酸メチル体(35)（２２．４ｇ，１３３ｍｍｏｌ）とジイソプロピルエチルアミン（i-Ｐｒ_２ＮＥｔ）（３５ｍＬ，２００ｍｍｏｌ）と臭化ベンジル（ＢｎＢｒ）（１８ｍＬ，１４６ｍｍｏｌ）との４５０ｍＬ無水塩化メチレン溶液を、撹拌しながら、一晩還流させた。反応終了後、有機溶媒を減圧下で留去したところ、４-(ベンジルオキシ)-２-ヒドロキシ安息香酸メチルが得られた。再結晶により精製して、純粋なものを得た。その４-(ベンジルオキシ)-２-ヒドロキシ安息香酸メチルとジメチル硫酸（１３．８ｍＬ，１４６ｍｍｏｌ）と炭酸カリウム（３６．８ｇ，２６６ｍｍｏｌ）との４００ｍＬアセトニトリル混合物を、撹拌しながら、一晩還流させた。反応混合物をセライト膜で濾過した。有機溶媒を留去した後、残渣を酢酸エチルで希釈し、水で洗浄した。その水相を酢酸エチルで抽出した。有機相を合わせ、飽和食塩水で洗浄し、無水硫酸マグネシウムで乾燥した後、有機溶媒を留去すると、定量的に４-(ベンジルオキシ)-２-メトキシ安息香酸メチル(36)が得られた。さらに再結晶により精製して、無色固体の純粋な４-ベンジルオキシ安息香酸メチル体(36)を得た。それの物性と分光学的データとを示す。
R_f 0.23 (展開溶媒 ヘキサン/酢酸エチル = 4:1).
FTIR (KBr) ν 1713, 1258 cm^-1.
¹H NMR (400 MHz, CDCl₃) δ 3.83 (3H, s), 5.07 (2H, s), 6.54 (1H,d, J = 5.4 Hz), 6.55 (1H, s), 7.73-7.43 (5H, m), 7.84 (1H, d, J = 9.5 Hz).
¹³C NMR (100 MHz, CDCl₃) δ 51.6, 55.9, 70.1, 99.8, 105.2，112.4，127.5 (×2), 128.2, 128.6 (×2), 133.8, 136.0, 161.2, 163.3, 166.0. (Synthesis of methyl 4- (benzyloxy) -2-methoxybenzoate (36))

A 450 mL anhydrous methylene chloride solution of methyl benzoate (35) (22.4 g, 133 mmol), diisopropylethylamine (i-Pr ₂ NEt) (35 mL, 200 mmol) and benzyl bromide (BnBr) (18 mL, 146 mmol) was added. Refluxed overnight with stirring. After completion of the reaction, the organic solvent was distilled off under reduced pressure to obtain methyl 4- (benzyloxy) -2-hydroxybenzoate. Purification by recrystallization gave a pure one. A 400 mL acetonitrile mixture of the methyl 4- (benzyloxy) -2-hydroxybenzoate, dimethyl sulfate (13.8 mL, 146 mmol) and potassium carbonate (36.8 g, 266 mmol) was refluxed overnight with stirring. . The reaction mixture was filtered through a celite membrane. After distilling off the organic solvent, the residue was diluted with ethyl acetate and washed with water. The aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and the organic solvent was evaporated to quantitatively obtain methyl 4- (benzyloxy) -2-methoxybenzoate (36). . The product was further purified by recrystallization to obtain a pure methyl 4-benzyloxybenzoate (36) as a colorless solid. Its physical properties and spectroscopic data are shown.
R _f 0.23 (developing solvent hexane / ethyl acetate = 4: 1).
FTIR (KBr) ν 1713, 1258 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ 3.83 (3H, s), 5.07 (2H, s), 6.54 (1H, d, J = 5.4 Hz), 6.55 (1H, s), 7.73-7.43 (5H, m), 7.84 (1H, d, J = 9.5 Hz).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 51.6, 55.9, 70.1, 99.8, 105.2, 112.4, 127.5 (× 2), 128.2, 128.6 (× 2), 133.8, 136.0, 161.2, 163.3, 166.0.

４-ベンジルオキシ安息香酸メチル体(36)（６.１５ｇ，２２.６ｍｍｏｌ）と水酸化パラジウム／炭素（２００ｍｇ）との酢酸エチル（ＡｃＯＥｔ）懸濁液を、水素ガス雰囲気下、室温で２日間撹拌した。混合物をセライト膜で濾過し、有機溶媒を留去すると、無色固体の４-ヒドロキシ-２-メトキシ安息香酸メチル(37)（４．０４ｇ，収率９９％）が得られた。その４-ヒドロキシ安息香酸メチル体(37)の物性と分光学的データとを示す。
R_f 0.25 (展開溶媒 ヘキサン/酢酸エチル = 1:1).
FTIR (KBr) ν 3308, 1699 cm^-1.
¹H NMR (400 MHz, CDCl₃) δ 3.80 (3H, s), 3.86 (3H, s), 6.44 (1H, dd, J = 2.3, 8.4 Hz), 6.46 (1H, d, J = 2.2 Hz), 7.80 (1H, d, J = 8.5 Hz).
¹³C NMR (100 MHz, CDCl₃) δ 51.8, 55.8, 99.5, 107.3, 111.3, 134.0, 161.4, 161.7, 166.6. (Synthesis of methyl 4-hydroxy-2-methoxybenzoate (37))

A suspension of methyl 4-benzyloxybenzoate (36) (6.15 g, 22.6 mmol) and palladium hydroxide / carbon (200 mg) in ethyl acetate (AcOEt) at room temperature under a hydrogen gas atmosphere for 2 days. Stir. The mixture was filtered through a celite membrane, and the organic solvent was distilled off to obtain methyl 4-hydroxy-2-methoxybenzoate (37) (4.04 g, yield 99%) as a colorless solid. The physical properties and spectroscopic data of the methyl 4-hydroxybenzoate (37) are shown.
R _f 0.25 (developing solvent hexane / ethyl acetate = 1: 1).
FTIR (KBr) ν 3308, 1699 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ 3.80 (3H, s), 3.86 (3H, s), 6.44 (1H, dd, J = 2.3, 8.4 Hz), 6.46 (1H, d, J = 2.2 Hz) , 7.80 (1H, d, J = 8.5 Hz).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 51.8, 55.8, 99.5, 107.3, 111.3, 134.0, 161.4, 161.7, 166.6.

４-ヒドロキシ安息香酸メチル体(37)（４．０ｇ，２２ｍｍｏｌ）の８０ｍＬ無水テトラヒドロフラン溶液に、トリエチルアミン（７．６７ｍＬ，５５ｍｍｏｌ）とtert-ブチルジメチルクロロシラン（３．６２ｇ，２４．２ｍｍｏｌ）とを、室温で加えた。混合物を一晩撹拌した。反応混合物に水を加え、反応を止めた。水相を酢酸エチルで抽出した。有機相を合わせ、飽和食塩水で洗浄した後、無水硫酸ナトリウムで乾燥させた。溶媒を留去した後、粗生成物をシリカゲルカラムクロマトグラフィーにより精製すると、無色油状物の４-{[tert-ブチル(ジメチル)シリル]オキシ}-２-メトキシ安息香酸メチル(38)（６．４４ｇ，収率９２％）が得られた。その４-シリルオキシ安息香酸メチル体(38)の物性と分光学的データとを示す。
R_f 0.42 (展開溶媒 ヘキサン/酢酸エチル = 2:1).
FTIR (neat) ν 1728, 1705, 1252 cm^-1.
¹H NMR (400 MHz, CDCl₃) δ0.23 (6H, s), 0.99 (9H, s), 3.85 (3H, s), 3.87 (3H, s), 6.43 (1H, d, J = 2.4 Hz), 6.43 (1H, dd, J = 2.2, 9.3 Hz), 7.77 (1H, d, J = 9.0 Hz).
¹³C NMR (100 MHz, CDCl₃) δ -4.3 (×2), 18.3, 25.6 (×3), 51.7, 55.9, 104.3, 111.7, 112.9. (Synthesis of methyl 4-{[tert-butyl (dimethyl) silyl] oxy} -2-methoxybenzoate (38))

To an 80 mL anhydrous tetrahydrofuran solution of methyl 4-hydroxybenzoate (37) (4.0 g, 22 mmol), triethylamine (7.67 mL, 55 mmol) and tert-butyldimethylchlorosilane (3.62 g, 24.2 mmol) were added. Added at room temperature. The mixture was stirred overnight. Water was added to the reaction mixture to stop the reaction. The aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, and dried over anhydrous sodium sulfate. After the solvent was distilled off, the crude product was purified by silica gel column chromatography. As a result, colorless oily methyl 4-{[tert-butyl (dimethyl) silyl] oxy} -2-methoxybenzoate (38) (6. 44 g, 92% yield). The physical properties and spectroscopic data of the methyl 4-silyloxybenzoate (38) are shown below.
R _f 0.42 (developing solvent hexane / ethyl acetate = 2: 1).
FTIR (neat) ν 1728, 1705, 1252 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ0.23 (6H, s), 0.99 (9H, s), 3.85 (3H, s), 3.87 (3H, s), 6.43 (1H, d, J = 2.4 Hz ), 6.43 (1H, dd, J = 2.2, 9.3 Hz), 7.77 (1H, d, J = 9.0 Hz).
¹³ C NMR (100 MHz, CDCl ₃ ) δ -4.3 (× 2), 18.3, 25.6 (× 3), 51.7, 55.9, 104.3, 111.7, 112.9.

４-シリルオキシ安息香酸メチル体(38)の１０ｍＬ無水テトラヒドロフラン溶液に、ジエチルアミン（Ｅｔ_２ＮＨ）（１ｍＬ，９．６ｍｍｏｌ）と１．５４Ｎのｎ−ブチルリチウムのヘキサン溶液（５ｍＬ，７．７ｍｍｏｌ）とから調製されたＥｔ_２ＮＬｉ溶液を、０℃で加えた。混合物を室温まで温め、３時間撹拌した。反応混合物に水を加え、反応を止めた。水相を酢酸エチルで抽出した。有機相を合わせ、飽和食塩水で洗浄した後、無水硫酸ナトリウムで乾燥させた。有機溶媒を留去した後、粗生成物をシリカゲルカラムクロマトグラフィーにより精製すると、黄色がかった固体の４-{[tert-ブチル(ジメチル)シリル]オキシ}-Ｎ,Ｎ-ジエチル-２-メトキシベンズアミド(39)（１．５２ｇ，収率７０％）が得られた。そのベンズアミド体(39)の物性と分光学的データとを示す。
R_f 0.36 (展開溶媒 ヘキサン/酢酸エチル = 2:1).
FTIR (neat) ν 3406, 1591, 1205 cm^-1.
¹H NMR (400 MHz, CDCl₃) δ 0.21 (6H, s), 0.99 (9H, s), 1.02 (3H, t, J = 7.3 Hz), 1.22 (3H, t, J = 7.2 Hz), 3.14 (2H, q, J = 7.1 Hz), 3.55 (2H, br), 6.43 (1H, d, J = 2.4 Hz), 6.43 (1H, dd, J = 2.2, 9.3 Hz), 7.77 (1H, d, J = 9.0 Hz).
¹³C NMR (100 MHz, CDCl₃) δ -4.4 (×2), 12.9,13.9,18.2, 25.6 (×3), 38.8, 51.7, 55.9, 104.3, 111.7, 112.9. (Synthesis of 4-{[tert-butyl (dimethyl) silyl] oxy} -N, N-diethyl-2-methoxybenzamide (39))

To a 10 mL anhydrous tetrahydrofuran solution of methyl 4-silyloxybenzoate (38), diethylamine (Et ₂ NH) (1 mL, 9.6 mmol) and a hexane solution of 1.54N n-butyllithium (5 mL, 7.7 mmol) and Et ₂ NLi solution prepared from was added at 0 ° C. The mixture was warmed to room temperature and stirred for 3 hours. Water was added to the reaction mixture to stop the reaction. The aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, and dried over anhydrous sodium sulfate. After distilling off the organic solvent, the crude product was purified by silica gel column chromatography to obtain yellowish solid 4-{[tert-butyl (dimethyl) silyl] oxy} -N, N-diethyl-2-methoxybenzamide. (39) (1.52 g, yield 70%) was obtained. The physical properties and spectroscopic data of the benzamide (39) are shown.
R _f 0.36 (developing solvent hexane / ethyl acetate = 2: 1).
FTIR (neat) ν 3406, 1591, 1205 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ 0.21 (6H, s), 0.99 (9H, s), 1.02 (3H, t, J = 7.3 Hz), 1.22 (3H, t, J = 7.2 Hz), 3.14 (2H, q, J = 7.1 Hz), 3.55 (2H, br), 6.43 (1H, d, J = 2.4 Hz), 6.43 (1H, dd, J = 2.2, 9.3 Hz), 7.77 (1H, d, J = 9.0 Hz).
¹³ C NMR (100 MHz, CDCl ₃ ) δ -4.4 (× 2), 12.9,13.9,18.2, 25.6 (× 3), 38.8, 51.7, 55.9, 104.3, 111.7, 112.9.

トルエンで水を共沸したベンズアミド体(39)（１．４５ｇ，４．３ｍｍｏｌ）とＮ,Ｎ,Ｎ,Ｎ-テトラメチル-１,２-エチレンジアミン（ＴＭＥＤＡ）（０．７１ｍＬ，４．７ｍｍｏｌ）との１５ｍＬ無水テトラヒドロフラン溶液に、０．５５Ｎのsec-ブチルリチウム（sec-ＢｕＬｉ）のシクロヘキサン溶液（８．６ｍＬ，４．７ｍｍｏｌ）を、−７８℃で撹拌しながら加えた。４時間後、反応混合液に、ベンズアルデヒド体(33)の２０ｍＬ無水テトラヒドロフラン溶液を、−７８℃で、加えた。この混合物を１時間撹拌した。反応混合物に水を加え、反応を止めた。水相を酢酸エチルで抽出した。有機相を合わせ、飽和食塩水で洗浄し、無水硫酸ナトリウムで乾燥させた。有機溶媒を留去した。得られた４-{[tert-ブチル(ジメチル)シリル]オキシ}-Ｎ,Ｎ-ジエチル-２-[ヒドロキシ(４-イソプロピル-３,５-ジメトキシフェニル)メチル]-６-メトキシベンズアミド(40)の粗生成物（３．７０ｇ）を、さらに精製することなく、次のラクトン化に用いた。 Synthesis of (4-{[tert-butyl (dimethyl) silyl] oxy} -N, N-diethyl-2- [hydroxy (4-isopropyl-3,5-dimethoxyphenyl) methyl] -6-methoxybenzamide (40) )

Benzamide (39) (1.45 g, 4.3 mmol) azeotroped with toluene and N, N, N, N-tetramethyl-1,2-ethylenediamine (TMEDA) (0.71 mL, 4.7 mmol) A cyclohexane solution (8.6 mL, 4.7 mmol) of 0.55 N sec-butyllithium (sec-BuLi) was added to a 15 mL anhydrous tetrahydrofuran solution with agitation at −78 ° C. with stirring. After 4 hours, a 20 mL anhydrous tetrahydrofuran solution of benzaldehyde (33) was added to the reaction mixture at −78 ° C. The mixture was stirred for 1 hour. Water was added to the reaction mixture to stop the reaction. The aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, and dried over anhydrous sodium sulfate. The organic solvent was distilled off. 4-{[tert-Butyl (dimethyl) silyl] oxy} -N, N-diethyl-2- [hydroxy (4-isopropyl-3,5-dimethoxyphenyl) methyl] -6-methoxybenzamide (40) The crude product of (3.70 g) was used for the next lactonization without further purification.

ベンズアミド体(40)とｐ−トルエンスルホン酸（ｐ−ＴｓＯＨ）（１００ｍｇ，０．５３ｍｍｏｌ）との３５ｍＬ１，２−ジクロロエタン溶液を、撹拌しながら、１０時間還流した。有機溶媒を留去した後、懸濁液を濾過し、酢酸エチルで洗浄し、無色固体のラクトン体である５-ヒドロキシ-３-(４-イソプロピル-３,５-ジメトキシフェニル)-７-メトキシ-２-ベンゾフラン-１(３Ｈ)-オン(41)（１．１３ｇ，２工程での収率７４％）を得た。このラクトン体(41)物性と分光学的データと元素分析結果とを示す。
R_f 0.39 (展開溶媒 ヘキサン/アセトン = 1:1).
FTIR (KBr) ν 3268, 1736 cm^-1
1H NMR (400 MHz, DMSO-d₆) δ 1.23 (6H, d, J = 7.1 Hz), 3.55 (1H, sept, J = 7.0 Hz), 3.76 (6H, s), 3.94 (3H, s), 6.34 (1H, s), 6.43 (1H, s), 6.43 (2H, s), 9.93 (1H, br).
¹³C NMR (100 MHz, DMSO-d₆) δ 20.5 (×2), 23.4, 33.2, 55.7 (×2), 65.7, 80.3, 97.2, 99.4, 101.1, 102.5, 103.0, 123.2, 136.6, 154.7, 158.2, 159.3, 165.5, 167.4.
Anal. Calcd for C₂₀H₂₂O₆: C, 67.03; H, 6.19; Found: C, 66.97; H, 6.04. (Synthesis of 5-hydroxy-3- (4-isopropyl-3,5-dimethoxyphenyl) -7-methoxy-2-benzofuran-1 (3H) -one (41))

A 35 mL 1,2-dichloroethane solution of benzamide (40) and p-toluenesulfonic acid (p-TsOH) (100 mg, 0.53 mmol) was refluxed for 10 hours with stirring. After distilling off the organic solvent, the suspension was filtered, washed with ethyl acetate, and 5-hydroxy-3- (4-isopropyl-3,5-dimethoxyphenyl) -7-methoxy which was a colorless solid lactone form. -2-Benzofuran-1 (3H) -one (41) (1.13 g, 74% yield over 2 steps) was obtained. The physical properties, spectroscopic data, and elemental analysis results of the lactone body (41) are shown.
R _f 0.39 (developing solvent hexane / acetone = 1: 1).
FTIR (KBr) ν 3268, 1736 cm ^-1
1 H NMR (400 MHz, DMSO-d ₆ ) δ 1.23 (6H, d, J = 7.1 Hz), 3.55 (1H, sept, J = 7.0 Hz), 3.76 (6H, s), 3.94 (3H, s) , 6.34 (1H, s), 6.43 (1H, s), 6.43 (2H, s), 9.93 (1H, br).
¹³ C NMR (100 MHz, DMSO-d ₆ ) δ 20.5 (× 2), 23.4, 33.2, 55.7 (× 2), 65.7, 80.3, 97.2, 99.4, 101.1, 102.5, 103.0, 123.2, 136.6, 154.7, 158.2 , 159.3, 165.5, 167.4.
Anal. Calcd for C ₂₀ H ₂₂ O ₆ : C, 67.03; H, 6.19; Found: C, 66.97; H, 6.04.

R_f 0.58 (展開溶媒 ヘキサン/アセトン = 2:1).
FTIR (neat) ν 1750, 1603 cm^-1.
¹H NMR (400 MHz, CDCl₃) δ 0.22(1), 0.22(8) (3H ×2, s), 0.97 (9H, s), 1.25 (6H, dd, J = 1.5, 7.1 Hz), 3.56 (1H, sept, J = 7.1 Hz), 3.75 (6H, s), 3.96 (3H, s), 6.15 (1H, s), 6.31 (1H, dd, J = 0.73, 1.7 Hz), 6.38 (2H, d, J = 7.0 Hz) 6.42 (2H, s).
¹³C NMR (100 MHz, CDCl₃) δ -4.3 (×2), 18.2, 20.5 (×2), 24.1, 25.2 (×3), 55.8 (×2), 56.0, 81.5, 103.0 (×2), 103.0, 105.8, 135.1, 154.0, 158.8 (×2), 159.6, 163.3, 168.3. Incidentally, 5-{[tert-butyl (dimethyl) silyl] oxy} -3- (4-isopropyl-3,5-dimethoxyphenyl) -7-methoxy-2-benzofuran-1 (3H) -one (42) is As a by-product. Its physical properties and spectroscopic data are shown.

R _f 0.58 (developing solvent hexane / acetone = 2: 1).
FTIR (neat) ν 1750, 1603 cm ^-1 .
¹ H NMR (400 MHz, CDCl ₃ ) δ 0.22 (1), 0.22 (8) (3H × 2, s), 0.97 (9H, s), 1.25 (6H, dd, J = 1.5, 7.1 Hz), 3.56 (1H, sept, J = 7.1 Hz), 3.75 (6H, s), 3.96 (3H, s), 6.15 (1H, s), 6.31 (1H, dd, J = 0.73, 1.7 Hz), 6.38 (2H, d, J = 7.0 Hz) 6.42 (2H, s).
¹³ C NMR (100 MHz, CDCl ₃ ) δ -4.3 (× 2), 18.2, 20.5 (× 2), 24.1, 25.2 (× 3), 55.8 (× 2), 56.0, 81.5, 103.0 (× 2), 103.0, 105.8, 135.1, 154.0, 158.8 (× 2), 159.6, 163.3, 168.3.

ラクトン体(41)（１２２ｍｇ，０．３４ｍｍｏｌ）と水酸化パラジウム／炭素（１５０ｍｇ）との２００ｍＬ酢酸エチル懸濁液を、水素ガス雰囲気下、室温で４日間撹拌した。反応混合物を、セライト膜で濾過し、溶媒を留去すると、無色固体の４-ヒドロキシ-２-(４-イソプロピル-３,５-ジメトキシベンジル)-６-メトキシ安息香酸(43)（１２２ｍｇ，収率９９％）が得られた。その安息香酸体(43)の物性と分光学的データとを示す。
R_f 0.31 (展開溶媒 ヘキサン/アセトン = 1:1).
FTIR (neat) ν 3382, 1678, 1595 cm^-1.
¹H NMR (400 MHz, CD₃OD) δ 1.23 (6H, d, J = 7.1 Hz), 3.52 (1H, sept, J = 7.0 Hz), 3.73 (6H, s), 3.85 (3H, s), 4.10 (2H, s), 6.30 (1H, d, J = 2.2 Hz), 6.35 (1H, d, J = 2.0 Hz) 6.41 (2H, s).
¹³C NMR (100 MHz, CD₃OD) δ 20.8 (×2), 23.8, 39.7, 55.7 (×2), 56.2, 97.5, 105.9 (×2), 110.4, 113.0, 121.9, 139.0, 144.3, 158.4 (×2), 159.0, 159.7, 168.5. (Synthesis of 4-hydroxy-2- (4-isopropyl-3,5-dimethoxybenzyl) -6-methoxybenzoic acid (43))

A 200 mL ethyl acetate suspension of the lactone compound (41) (122 mg, 0.34 mmol) and palladium hydroxide / carbon (150 mg) was stirred at room temperature for 4 days in a hydrogen gas atmosphere. The reaction mixture was filtered through a celite membrane, and the solvent was distilled off. Then, 4-hydroxy-2- (4-isopropyl-3,5-dimethoxybenzyl) -6-methoxybenzoic acid (43) (122 mg, yield) was obtained as a colorless solid. 99%) was obtained. The physical properties and spectroscopic data of the benzoic acid derivative (43) are shown.
R _f 0.31 (developing solvent hexane / acetone = 1: 1).
FTIR (neat) ν 3382, 1678, 1595 cm ^-1 .
¹ H NMR (400 MHz, CD ₃ OD) δ 1.23 (6H, d, J = 7.1 Hz), 3.52 (1H, sept, J = 7.0 Hz), 3.73 (6H, s), 3.85 (3H, s), 4.10 (2H, s), 6.30 (1H, d, J = 2.2 Hz), 6.35 (1H, d, J = 2.0 Hz) 6.41 (2H, s).
¹³ C NMR (100 MHz, CD ₃ OD) δ 20.8 (× 2), 23.8, 39.7, 55.7 (× 2), 56.2, 97.5, 105.9 (× 2), 110.4, 113.0, 121.9, 139.0, 144.3, 158.4 ( × 2), 159.0, 159.7, 168.5.

安息香酸体(43)（３４３ｍｇ，０．９５ｍｍｏｌ）の１００ｍＬ無水クロロホルム液を０℃に冷却し、それに、新たに蒸留したトリルルオロ酢酸無水物（ＴＦＡＡ）（７８１ｍｇ，３．７ｍｍｏｌ）を、窒素雰囲気下で加えた。混合物を、０℃で３０分間撹拌した後、室温で一晩撹拌した。反応混合物からトリルルオロ酢酸無水物とＣＨＣｌ_３を減圧下で除去し、そこに飽和炭酸カリウム水溶液を加えた。水相をクロロホルムで抽出した。有機相を合わせ、飽和食塩水で洗浄した後、無水硫酸ナトリウムで乾燥させた。溶媒を留去した後、残渣を、３０ｍＬメタノール（ＭｅＯＨ）で希釈した後、酸素雰囲気下で１日間撹拌した。懸濁液を濾過し、メタノールで洗浄すると、黄色固体の６-ヒドロキシ-２-イソプロピル-１,３,８-トリメトキシアントラ-９,１０-キノン(44)（３１４ｍｇ，収率９３％）が得られた。そのトリメトキシアントラキノン体(44)の物性と分光学的データとを示す。なおUVは吸光度測定法である。
R_f 0.25 (展開溶媒 ヘキサン/アセトン = 2:1).
融点 246 ℃ (分解).
FTIR (KBr) ν 3462, 1639, 1591 cm^-1.
UV λmax 280 (ε = 12000), 346 (ε = 2200) nm.
¹H NMR (400 MHz, CDCl₃) δ 1.34 (6H, d, J = 7.1 Hz), 3.69 (1H, sept, J = 7.1 Hz), 3.89 (3H, s), 3.94 (3H, s), 3.96 (3H, s), 6.74 (1H, d, J = 2.2 Hz), 7.18 (1H, d, J = 2.2 Hz) 7.45 (1H, s).
¹³C NMR (100 MHz, CDCl₃) δ 20.4 (×2), 25.2, 55.6, 56.3, 62.6, 104.6, 105.3, 105.6, 116.7, 120.0, 133.3, 136.1, 159.3, 162.1, 162.3, 162.4, 181.4, 184.3. (Synthesis of 6-hydroxy-2-isopropyl-1,3,8-trimethoxyanthra-9,10-quinone (44))

A 100 mL anhydrous chloroform solution of the benzoic acid compound (43) (343 mg, 0.95 mmol) was cooled to 0 ° C., and freshly distilled tolyluro acetic anhydride (TFAA) (781 mg, 3.7 mmol) was added under a nitrogen atmosphere. Added in. The mixture was stirred at 0 ° C. for 30 minutes and then at room temperature overnight. Tolyluro acetic anhydride and CHCl ₃ were removed from the reaction mixture under reduced pressure, and a saturated aqueous potassium carbonate solution was added thereto. The aqueous phase was extracted with chloroform. The organic phases were combined, washed with saturated brine, and dried over anhydrous sodium sulfate. After the solvent was distilled off, the residue was diluted with 30 mL methanol (MeOH) and then stirred for 1 day under an oxygen atmosphere. The suspension was filtered and washed with methanol to give 6-hydroxy-2-isopropyl-1,3,4-trimethoxyanthra-9,10-quinone (44) (314 mg, 93% yield) as a yellow solid. Obtained. The physical properties and spectroscopic data of the trimethoxyanthraquinone (44) are shown. UV is an absorbance measurement method.
R _f 0.25 (developing solvent hexane / acetone = 2: 1).
Melting point 246 ℃ (decomposition).
FTIR (KBr) ν 3462, 1639, 1591 cm ^-1 .
UV λmax 280 (ε = 12000), 346 (ε = 2200) nm.
¹ H NMR (400 MHz, CDCl ₃ ) δ 1.34 (6H, d, J = 7.1 Hz), 3.69 (1H, sept, J = 7.1 Hz), 3.89 (3H, s), 3.94 (3H, s), 3.96 (3H, s), 6.74 (1H, d, J = 2.2 Hz), 7.18 (1H, d, J = 2.2 Hz) 7.45 (1H, s).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 20.4 (× 2), 25.2, 55.6, 56.3, 62.6, 104.6, 105.3, 105.6, 116.7, 120.0, 133.3, 136.1, 159.3, 162.1, 162.3, 162.4, 181.4, 184.3 .

トリメトキシアントラキノン体(44)（７４ｍｇ，０．２１ｍｍｏｌ）の１０ｍＬ無水塩化メチレン懸濁液に、無水塩化アンモニウム（２８０ｍｇ，２．１ｍｍｏｌ）を、０℃で加えた。混合物を２時間撹拌した後、室温に温めた。反応混合物を、室温で１２時間撹拌した。それを、氷片と濃塩酸との混合物に注ぎ込んだ後、３０分間湯浴上で溶解させた。この混合物を、室温まで放冷した後、クロロホルムと酢酸エチルとで抽出した。有機相を合わせ、無水硫酸ナトリウムで乾燥させた。有機溶媒を留去した後、残渣をシリカゲルカラムクロマトグラフィーにより精製すると、橙色固体の１,６,８-トリヒドロキシ-２-イソプロピル-３-メトキシアントラ-９,１０-キノン(45)（５０ｍｇ，収率７７％）が得られた。そのアントラキノン体(45)の物性と分光学的データとを示す。図１に¹H NMRの測定チャートを示し、図２に¹³C NMRの測定チャートを示す。これらのデータは、(45)の化学構造を支持する。
R_f 0.40 (展開溶媒 ヘキサン/アセトン = 2:1).
融点 233.5-235.5 ℃.
FTIR (KBr) ν 3314, 3229, 1622 cm^-1.
¹H NMR (400 MHz, acetone-d₆) δ 1.34 (6H, d, J = 7.1 Hz), 3.69 (1H, sept, J = 7.1 Hz), 4.04 (3H, s), 6.59 (1H, d, J = 2.2Hz), 7.17 (1H, d, J = 2.2 Hz), 7.30 (1H, s), 12.14 (1H,s), 12.66 (1H,s).
¹³C NMR (100 MHz, CDCl₃) δ 19.7 (×2), 24.1, 55.8, 103.4, 108.5, 109.2, 109.4, 110.4, 130.0, 132.3, 135.0, 161.9, 163.5, 164.7, 182.5 (×2). (Synthesis of 1,6,8-trihydroxy-2-isopropyl-3-methoxyanthra-9,10-quinone (45))

To a 10 mL anhydrous methylene chloride suspension of the trimethoxyanthraquinone compound (44) (74 mg, 0.21 mmol), anhydrous ammonium chloride (280 mg, 2.1 mmol) was added at 0 ° C. The mixture was stirred for 2 hours before warming to room temperature. The reaction mixture was stirred at room temperature for 12 hours. It was poured into a mixture of ice pieces and concentrated hydrochloric acid and then dissolved on a hot water bath for 30 minutes. The mixture was allowed to cool to room temperature and extracted with chloroform and ethyl acetate. The organic phases were combined and dried over anhydrous sodium sulfate. After distilling off the organic solvent, the residue was purified by silica gel column chromatography to obtain 1,6,8-trihydroxy-2-isopropyl-3-methoxyanthra-9,10-quinone (45) (50 mg, 50 mg, Yield 77%) was obtained. The physical properties and spectroscopic data of the anthraquinone (45) are shown. FIG. 1 shows a ¹ H NMR measurement chart, and FIG. 2 shows a ¹³ C NMR measurement chart. These data support the chemical structure of (45).
R _f 0.40 (developing solvent hexane / acetone = 2: 1).
Melting point 233.5-235.5 ℃.
FTIR (KBr) ν 3314, 3229, 1622 cm ^-1 .
¹ H NMR (400 MHz, acetone-d ₆ ) δ 1.34 (6H, d, J = 7.1 Hz), 3.69 (1H, sept, J = 7.1 Hz), 4.04 (3H, s), 6.59 (1H, d, J = 2.2Hz), 7.17 (1H, d, J = 2.2 Hz), 7.30 (1H, s), 12.14 (1H, s), 12.66 (1H, s).
¹³ C NMR (100 MHz, CDCl ₃ ) δ 19.7 (× 2), 24.1, 55.8, 103.4, 108.5, 109.2, 109.4, 110.4, 130.0, 132.3, 135.0, 161.9, 163.5, 164.7, 182.5 (× 2).

トリヒドロキシアントラキノン体(45)（１００ｍｇ、０．３ｍｍｏｌ）とヒドロキノン（０．９１ｍｍｏｌ）と０．６Ｎの水酸化カリウム水溶液との混合物を、ポリテトラフルオロエチレン製の反応容器に入れて密閉し、加圧装置（光高圧機器株式会社製；製品番号ＨＲ−１５型）を用いて０．８ＧＰａの高圧に加圧しつつ、１５０℃で２４時間反応させた。反応混合物を、０．１Ｎ塩酸でｐＨ１になるまで酸性化してから、溶媒を留去し、中間体を黒色の残渣として得た。これを精製することなく、アセトン−メタノール（１：１）混合溶媒で希釈した後、窒素雰囲気下、日光に６時間晒した。暗赤色の懸濁液を、減圧下で、濃縮した。残渣を、シュウ酸塩処理シリカゲルカラムクロマトグラフィー（溶出溶媒 ヘキサン/酢酸エチル= 4:1）で精製した。さらに、セファデックス（ＧＬヘルスケアバイオサイエンス社製；登録商標）を用い、溶離液として塩化メチレン/メタオール(4:1)でのゲル濾過により、黒色固体のフェナントロピレン ジオン類であるステントリンＣ-(OMe)₂ (46)（収率３０〜４０％）が得られた。それの物性と分光学的データとを示す。なお、HRMS (FAB)は、高分解能マススペクトロメトリー（高速原子衝撃法）である。図３に¹H NMRの測定チャートを示し、図４に¹³C NMRの測定チャートを示す。これらのデータは、ステントリンＣ-(OMe)₂ (46)の化学構造を支持する。
R_f 0.45 (展開溶媒 ヘキサン/酢酸エチル = 2:1, シュウ酸塩処理シリカゲル).
¹H NMR (400 MHz, acetone-d₆) δ 1.53 (6H, d, J = 7.1 Hz), 1.63 (6H, d, J = 7.1 Hz), 3.48 (3H, s), 4.08 (2H, sept, J = 7.1Hz), 6.66 (2H, s), 14.75 (2H, s), 15.32 (2H, s).
¹³C NMR (100 MHz, acetone-d₆ ) δ 20.9 (×2), 21.6 (×2), 25.8 (×2), 61.7 (×2), 103.1 (×2), 106.7 (×2), 107.7 (×2), 112.3 (×2), 120.9 (×2), 122.8 (×2), 126.5 (×2), 128.2 (×2), 128.7 (×2), 163.2 (×2), 164.3 (×2), 169.6 (×2), 176.3 (×2), 184.6 (×2).
HRMS (FAB) calcd. for C₃₆H₂₇O₁₀ (M-H⁺) 620.6015, found 619.1595. (1,6,8,10,11,13-hexahydroxy-2,5-diisopropyl-3,4-dimethoxyphenanthro [1,10,9,8-opqra] perylene-7,14-dione (stent Synthesis of phosphorus C- (OMe) ₂ ) (46)

A mixture of trihydroxyanthraquinone (45) (100 mg, 0.3 mmol), hydroquinone (0.91 mmol) and a 0.6 N aqueous potassium hydroxide solution was placed in a polytetrafluoroethylene reaction vessel, sealed, and added. The reaction was carried out at 150 ° C. for 24 hours while pressurizing to a high pressure of 0.8 GPa using a pressure device (manufactured by Optical High Pressure Equipment Co., Ltd .; product number HR-15 type). The reaction mixture was acidified with 0.1N hydrochloric acid until pH 1 and then the solvent was distilled off to give the intermediate as a black residue. Without purification, this was diluted with an acetone-methanol (1: 1) mixed solvent and then exposed to sunlight for 6 hours under a nitrogen atmosphere. The dark red suspension was concentrated under reduced pressure. The residue was purified by oxalate-treated silica gel column chromatography (elution solvent hexane / ethyl acetate = 4: 1). Furthermore, using Sephadex (manufactured by GL Healthcare Biosciences; registered trademark) and gel filtration with methylene chloride / methol (4: 1) as an eluent, Stentrin C, which is a phenanthropyrene dione of black solids -(OMe) ₂ (46) (yield 30-40%) was obtained. Its physical properties and spectroscopic data are shown. HRMS (FAB) is high resolution mass spectrometry (fast atom bombardment method). FIG. 3 shows a measurement chart of ¹ H NMR, and FIG. 4 shows a measurement chart of ¹³ C NMR. These data support the chemical structure of stentrin C- (OMe) ₂ (46).
R _f 0.45 (developing solvent hexane / ethyl acetate = 2: 1, oxalate-treated silica gel).
¹ H NMR (400 MHz, acetone-d ₆ ) δ 1.53 (6H, d, J = 7.1 Hz), 1.63 (6H, d, J = 7.1 Hz), 3.48 (3H, s), 4.08 (2H, sept, J = 7.1Hz), 6.66 (2H, s), 14.75 (2H, s), 15.32 (2H, s).
¹³ C NMR (100 MHz, acetone-d ₆ ) δ 20.9 (× 2), 21.6 (× 2), 25.8 (× 2), 61.7 (× 2), 103.1 (× 2), 106.7 (× 2), 107.7 (× 2), 112.3 (× 2), 120.9 (× 2), 122.8 (× 2), 126.5 (× 2), 128.2 (× 2), 128.7 (× 2), 163.2 (× 2), 164.3 (× 2), 169.6 (× 2), 176.3 (× 2), 184.6 (× 2).
HRMS (FAB) calcd.for C ₃₆ H ₂₇ O ₁₀ (MH ⁺ ) 620.6015, found 619.1595.

Stentrin C- (OMe) ₂ (46) can also be purified by a separation method using Centrifugal Partition Chromatography. As a developing solvent in that case, hexane / ethyl acetate / methanol / water = 55: 45: 55: 45 was optimal.

ステントリンＣ-(OMe)₂ (46)（１５ｍｇ、２４μｍｏｌ）を、加熱しながら３．０ｍＬの酢酸に溶解した後、次亜リン酸ナトリウム（５６ｍｇ）とヨウ化水素酸（１０滴）とを加えた。その混合物に、さらにヨウ化水素酸を１０滴ずつ３回加えつつ、３２時間還流させた。反応混合物を放冷し、水に注ぎこんだ。得られた沈殿物を、集めて水で洗浄してから、乾燥した。それをシリカゲル分取薄層クロマトグラフィーに付し、溶離液として、アセトン/トルエン/酢酸（43:56:1）で精製した。えび茶色の主バンドからアセトンで溶出させ、有機溶媒を留去すると、黒色固体のステントリンＣ(2)が得られた。それの物性と分光学的データとを示す。
R_f 0.13(展開溶媒 酢酸エチル/アセトン = 1:1).
¹H NMR (400 MHz, DMSO-d₆) δ1.51 (12H, d, J = 7.1 Hz), 6.56 (2H, s), 14.61 (2H, s), 15.09 (2H, s). (1,3,4,6,8,10,11,13-Okrahydroxy-2,5-diisopropylphenanthro [1,10,9,8-opqra] perylene-7,14-dione (Stentrin C ) (2) synthesis)

Stentrin C- (OMe) ₂ (46) (15 mg, 24 μmol) was dissolved in 3.0 mL of acetic acid while heating, and then sodium hypophosphite (56 mg) and hydroiodic acid (10 drops) were added. added. The mixture was further refluxed for 32 hours while adding 10 drops of hydroiodic acid three times. The reaction mixture was allowed to cool and poured into water. The resulting precipitate was collected, washed with water and then dried. It was subjected to silica gel preparative thin layer chromatography and purified with acetone / toluene / acetic acid (43: 56: 1) as the eluent. Elution from the maroon main band with acetone and evaporation of the organic solvent yielded a black solid stentrin C (2). Its physical properties and spectroscopic data are shown.
R _f 0.13 (developing solvent ethyl acetate / acetone = 1: 1).
¹ H NMR (400 MHz, DMSO-d ₆ ) δ1.51 (12H, d, J = 7.1 Hz), 6.56 (2H, s), 14.61 (2H, s), 15.09 (2H, s).

The obtained Stentrin C and the standard Stentrin C described in Non-Patent Document 2 were compared in chemical shift (δ), binding constant (J) and multiplicity in ¹ H NMR. The results are shown in Table 1.

As apparent from Table 1, the obtained stentrin C and the standard stentrin C described in Non-Patent Document 2 have the same chemical shift, binding constant, and multiplicity in ¹ H NMR. . From this, it was confirmed that the obtained stentrin C was the one represented by the chemical formula (2).

  According to the method for producing a condensed polycyclic compound of the present invention, a condensed polycyclic compound that becomes an in vivo dye, an antibacterial agent, an antiviral agent, an organic dye, or the like can be produced simply and with good yield. In particular, anthraquinone derivatives having low reactivity can be directly ring-condensed by dimerization to produce a large amount of a condensed polycyclic compound having a phenanthropyrene dione skeleton in good stereoselective yield.

  Among the condensed polycyclic compounds, stentrin C is useful as an anti-HIV agent. It is useful as a reagent for its pharmaceutical or medical research and as a raw material for anti-HIV preparations.

It is a diagram showing a measurement chart of ¹ H NMR of the anthraquinones used in the production method of the fused polycyclic compound of applying the present invention.

It is a figure which shows the measurement chart of ¹³ C NMR of the anthraquinones used for the manufacturing method of the condensed polycyclic compound to which this invention is applied.

FIG. 3 is a diagram showing a ¹ H NMR measurement chart of phenanthropyrene diones, which are target products in the method for producing a condensed polycyclic compound to which the present invention is applied.

It is a figure which shows the measurement chart of ¹³ C NMR of the phenanthropyrene dione which is the target object in the manufacturing method of the condensed polycyclic compound to which this invention is applied.

Claims (6)

Anthraquinones in which positions 1, 2, 7, and 8 may be unsubstituted, and positions 3 and 6 are substituted with a free hydroxyl group or substituted with a hydroxyl group protected by a protecting group, and positions 4 and 5 are unsubstituted. It is exposed to a high pressure of 1 × 10 ⁸ to 1 × 10 ¹⁰ Pa, and the two molecules are bonded to each other between the carbon atoms at the 10th position and any one of the carbon atoms at the 4th and 5th positions to form a dimer. A process for producing a condensed polycyclic compound characterized by comprising:   2. The condensed polymer according to claim 1, wherein the dimer is irradiated with light to bond the other carbon atoms at the 4th and 5th positions of the anthraquinones to phenanthropyrene diones. A method for producing a ring compound.   3. The anthraquinones are substituted with at least one of the 3,6 positions with a hydroxyl group protected by the protecting group, and the protecting group is cleaved from the phenanthropylene dione. The manufacturing method of the condensed polycyclic compound of description.   One of the 3,6 positions of the anthraquinones is substituted with the free hydroxyl group, and the other is substituted with a hydroxyl group protected by the protecting group selected from an alkyl group, an aralkyl group and an acyl group. Is substituted with a free hydroxyl group or a hydroxyl group protected by a protecting group selected from an alkyl group, an aralkyl group and an acyl group, and at least one of the 2,7 positions is substituted with an alkyl group The method for producing a condensed polycyclic compound according to any one of claims 1 to 3. The anthraquinones are represented by the following chemical formula (1)

(In the chemical formula (1), R is the protecting group), which is exposed to the high pressure under alkaline conditions to form the dimer, and then irradiated with light to form the phenanthropyrene dione. Then, the protecting group is cleaved under acidic conditions to obtain the following chemical formula (2)

The method for producing a condensed polycyclic compound according to claim 4, wherein Stentrin C is represented by the formula:   4-alkyl or alkenyl-3,5-dialkoxybenzaldehyde reduced by reacting 3,4,5-trialkoxybenzoate with alkylmagnesium halide or alkenylmagnesium halide, and 2-alkoxy-4-trialkyl After reacting with ortho-thiothiol of siloxybenzoic acid N, N-dialkylamide, in the order of lactonization reaction under acidic conditions, catalytic reduction reaction, intramolecular Friedel-Crafts reaction, oxidation reaction and alkoxy cleavage reaction A method for producing anthraquinones characterized by reacting.

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