JP2007303987A - Chromatographic device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a chromatographic device, capable executing confirmation of measurement interim progress of chromatograms, without performing always waveform observation by viewing. <P>SOLUTION: A circuit that outputts voltage change as a voice, luminance of light, or the change in the flashing intervals, is connected to a circuit outputting a chromatogram as voltage change, and a speaker or a light source is connected as an output device of the former circuit; and since a constitution is adopted, where peak generation in a measurement output from the chromatograph device 1 is reported by the change in sound or light, operator can recognize generation of peaks, while performing another work or the like, without having to observe waveforms observation of chromatograms at all times by viewing. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a chromatographic apparatus such as a gas chromatograph or a liquid chromatograph.

  In a chromatographic apparatus such as a liquid chromatograph or a gas chromatograph described in Non-Patent Document 1, for example, a data processing apparatus is used for identification and quantification of components to be analyzed.

  Chromatograms are generally output to paper of a data processing device or displayed on a computer display, and not only final results but also confirmation of progress is confirmed on these papers or computer displays. .

  This is because the operator needs to adjust the conditions by observing the shape of the chromatogram.

"Gas Chromatograph", 3rd edition, written by Shun Araki, Tokyo Chemical Doujin, p7-9

  In a chromatograph, it is usually necessary for several tens of minutes from introducing a sample into a chromatographic apparatus until a resultant chromatogram is obtained, and depending on the type of sample, it often takes 1 hour or more.

  When measuring a sample with a known composition repeatedly, since the shape of the chromatogram is the same as the first time after the second time, it is not necessary to observe the progress in the second time and later, and the analysis is complete. You can check it by looking around.

  However, when measuring a sample whose chromatogram shape is unknown, the chromatogram shape must always be visually observed. For this reason, during unknown sample measurement, the operator cannot avoid other work, or the other work must be interrupted frequently, so that the overall work efficiency is inevitably lowered.

  An object of the present invention relates to the realization of a chromatographic apparatus capable of confirming the progress of measurement of a chromatogram without always performing it by visually observing a waveform.

  According to the present invention, in the chromatograph apparatus or the chromatograph data processing apparatus, the chromatogram of the measurement sample is displayed on the screen, and the sound or light corresponding to the chromatogram of the measurement sample is generated and notified.

  According to the present invention, it is possible to realize a chromatograph apparatus and a chromatographic data processing apparatus that can be executed without constantly performing confirmation of the progress of measurement of a chromatogram by visually observing a waveform.

Embodiments of the present invention will be described below with reference to the accompanying drawings.
FIG. 1 is a schematic configuration diagram of a chromatographic analysis system to which an embodiment of the present invention is applied.

  In FIG. 1, in the chromatograph apparatus 1, the sample introduced from the sample introduction unit 2 is separated by the column 3 and reaches the detector 4. The detector 4 outputs an electric signal as a change in current or voltage according to the concentration or absolute amount of the sample that has reached. The electrical signal output from the detector 4 is output from the chromatogram signal output terminal 6 as a voltage change by the amplifier 5.

The data processing device 7 connected to the chromatogram signal output terminal 6 continuously records the change in the output voltage of the output terminal 6 and displays the relationship between time and voltage on the computer display screen 8 or the paper of the printer 9. 10 is printed.
Here, the graph of the relationship between the output time and voltage is called a chromatogram 11.

  FIG. 2 is a diagram showing a typical chromatogram. In the chromatogram of FIG. 2, a continuous line when there is no sample is called a baseline 12, and a line when the sample reaches the detector 4 is called a peak 13.

  FIG. 3 is a diagram showing a typical peak 13. In FIG. 3, the portion of the peak 13 where the distance from the virtually drawn baseline 12 is the maximum is called the peak top 14, and the distance between the virtually drawn baseline 12 and the peak top 14 is the peak. Called height 15. The area between the virtually drawn base line 12 and the peak 13 line is called a peak area 16.

  In each peak 13, the time until the peak top 14 is obtained after the introduction of the sample is called a retention time (retention time), and the component is identified by this retention time. In each peak 13, quantification is performed by the peak area 16.

  In the chromatogram analysis system having the above-described configuration, the present invention notifies that a peak has occurred during sample measurement using sound, light, or the like.

  A method for outputting a change in the voltage of the chromatogram signal as a change in the brightness of the voice or light or the blinking interval is as follows.

  FIG. 4 is a schematic explanatory diagram of a data processing apparatus for chromographs according to the present invention. In FIG. 4, a circuit 18 that outputs a change in voltage as a change in voice or light brightness or a blinking interval is connected to a circuit 17 that outputs a chromatogram as a change in voltage. As an output device of the circuit 18, a speaker 19 or a light source 20 is connected.

  The circuit 17 that outputs a chromatogram as a change in voltage corresponds to the amplifier 5 in the chromatograph apparatus 1 shown in FIG.

  A circuit 18 for outputting a change in voltage as a change in voice or light luminance or a blinking interval is provided between the amplifier 5 and the chromatogram signal output terminal 6 when incorporated in the chromatograph apparatus 1 shown in FIG. It is done. In the case where the circuit 18 is built in the data processing device 7 shown in FIG.

  4 is used as an independent device, it is connected to the chromatogram signal output terminal 6 of the chromatograph device 1 together with the data processing device 7 in FIG. .

  The principle of the circuit 18 that outputs a change in voltage as a change in voice or light luminance or blinking interval is as follows.

  As shown in FIG. 5, the voltage of the electrical signal 21 of the chromatogram input to the circuit 18 is measured at a fixed time interval (for example, every several milliseconds to several seconds) set to an arbitrary value. Is done. The absolute value of the measured voltage ((B) in FIG. 5) or the voltage change rate 22 ((A) in FIG. 5) corresponds to the absolute value or the change rate 22 on an electric circuit or software. It is converted on a one-to-one basis into the frequency of sound or the luminance of the light source ((A), (C) in FIG. 6) or the interval between sound or light emission ((B), (D) in FIG. 6).

  For example, when the audio frequency corresponds to the absolute value of the voltage, it corresponds to 400 Hz when the voltage is 0 μV, and 600 Hz when the voltage is 1000 μV.

  Further, for example, when the light emission interval is made to correspond to the voltage change rate, when the voltage change rate is 0 μV / 100 milliseconds, blinking is performed every 200 milliseconds, and the voltage change rate is 1000 μV / 100 milliseconds. Sometimes, it is made to respond such as blinking every 100 milliseconds.

As described above, according to an embodiment of the present invention, a means for generating sound or light corresponding to the measurement output of the chromatograph device is provided, and the occurrence of a peak is notified by a change in sound or light. Thus, the operator need not always perform the chromatogram by visually observing the waveform, and can recognize the occurrence of the peak while performing other operations.
As a result, it is possible to realize a chromatographic apparatus that can be executed without confirming the progress of the chromatogram measurement by visual observation of the waveform at all times, thereby improving the overall work efficiency of the chromatographic apparatus. .

  In the graph illustrated in FIG. 6, the relationship between the absolute value of the voltage or the rate of change 22 and the frequency of the sound, the luminance of the light source, or the interval of the sound or light emission is displayed as a linear relationship. It is not always necessary to correspond in a straight line relationship.

  In addition, when the means for notifying the occurrence of a peak is sound, in addition to sound generated by an oscillator such as “sine wave”, “triangular wave”, “sawtooth wave”, “square wave”, etc., it is stored in an electronic storage device (memory). Sampling audio (human voice, etc.) can also be used.

  In addition, when the means for notifying the occurrence of a peak is light, it is possible to freely select colors.

  Thereby, when a plurality of chromatograph apparatuses are installed nearby, it is possible to determine which apparatus is in the tone color or the light color.

  In addition, the absolute value of the voltage level of the electric signal of the chromatogram or the rate of change of the voltage is fixed in advance or arbitrarily set (for example, rate of change = 100 μV / second). Alternatively, when a predetermined continuous time (for example, 10 minutes) is not exceeded, a special sound can be generated or a special light source can be turned on.

  Thereby, it can be set as one standard for judging that the analysis is finished (all peaks are finished).

1 is a schematic configuration diagram of a chromatographic analysis system to which an embodiment of the present invention is applied. It is explanatory drawing of a chromatogram. It is explanatory drawing of the peak of a chromatogram. It is a schematic explanatory drawing of one Embodiment in this invention. It is a principle explanatory view of one embodiment in the present invention. It is a schematic explanatory drawing of one Embodiment in this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Chromatograph apparatus 2 Sample introduction part 3 Column 4 Detector 5 Amplifier 6 Chromatogram signal output terminal 7 Data processing apparatus 8 Computer display screen 9 Printer 10 Paper 11 Chromatogram 12 Baseline 13 Peak 14 Peak top 15 Peak height 16 Peak area 17 Circuit that outputs chromatogram as change in voltage 18 Circuit that outputs change in voltage as change in voice, etc. 19 Speaker 20 Light source 21 Electric signal in chromatogram 22 Voltage change rate

Claims (15)

In chromatographic equipment,
Means for displaying the chromatogram of the measurement sample on the screen;
Informing means for generating and informing sound or light corresponding to the chromatogram of the measurement sample,
A chromatographic apparatus comprising:   2. The chromatograph according to claim 1, wherein the notification means outputs intermittent sounds at regular intervals when the chromatogram has a constant value, and according to the rate of change when the chromatogram changes. A chromatographic apparatus characterized by changing the interval of intermittent sound.   2. The chromatograph according to claim 1, wherein the notifying means outputs a sound having a constant frequency when the chromatogram has a constant value, and according to an absolute value of the chromatogram when a change occurs in the chromatogram. A chromatographic apparatus characterized by changing the frequency of sound.     2. The chromatograph according to claim 1, wherein the notification means outputs intermittent sounds at regular intervals when the chromatogram has a constant value, and the absolute value of the chromatogram when a change occurs in the chromatogram. The chromatograph apparatus characterized by changing the interval of the intermittent sound according to.   2. The chromatograph according to claim 1, wherein the notifying means outputs a sound having a constant frequency when the chromatogram has a constant value, and according to the rate of change of the chromatogram when a change occurs in the chromatogram. A chromatographic apparatus characterized by changing the frequency of sound.   2. The chromatograph according to claim 1, wherein the notifying means blinks light at regular intervals when the chromatogram has a constant value, and according to the rate of change of the chromatogram when a change occurs in the chromatogram. A chromatograph apparatus characterized by changing a blinking interval of light.   2. The chromatograph according to claim 1, wherein the notification means generates light having a constant luminance when the chromatogram has a constant value, and according to an absolute value of the chromatogram when a change occurs in the chromatogram. A chromatographic apparatus characterized by changing the luminance of generated light.   2. The chromatograph according to claim 1, wherein the informing means blinks light at regular intervals when the chromatogram has a constant value, and according to the absolute value of the chromatogram when a change occurs in the chromatogram. A chromatograph apparatus characterized by changing a blinking interval of light.   2. The chromatograph according to claim 1, wherein the notification means generates light having a constant luminance when the chromatogram has a constant value, and according to the rate of change of the chromatogram when a change occurs in the chromatogram. A chromatographic apparatus characterized by changing the luminance of generated light.   2. The chromatograph according to claim 1, wherein the notifying means has means for storing a plurality of kinds of sounds, and generates sounds corresponding to the chromatograms among the sounds stored in the storage means. A chromatographic apparatus.   2. The chromatographic apparatus according to claim 1, wherein the notification means generates a sound or light indicating that a state where the chromatogram has a constant value has passed for a predetermined period or longer. A chromatographic data processing device for processing chromatogram data output from a chromatographic device,
A chromatograph data processing apparatus comprising a notifying means for generating and notifying sound or light corresponding to the chromatogram data.   13. The chromatographic data processing apparatus according to claim 12, wherein the notification means outputs a constant sound when the chromatogram has a constant value, and sounds different from the constant sound when a change occurs in the chromatogram. A data processing apparatus for chromatograph, characterized in that   13. The chromatographic data processing apparatus according to claim 12, wherein the informing means generates a constant light when the chromatogram has a constant value, and a light different from the constant light when a change occurs in the chromatogram. A data processing apparatus for chromatograph, characterized in that   13. The chromatograph data processing apparatus according to claim 12, wherein said notifying means generates a sound or light indicating that a state of a chromatogram having a constant value has passed for a certain period of time. Data processing equipment.

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