JP2007278887A - Dispensing device and dispensing probe unit - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To accurately perform dispensing without being affected by pressure or change over time. <P>SOLUTION: The dispensing device has a dispensing probe 110 whose both ends are opened, and sucks liquid into the dispensing probe 110 by making negative pressure act from an upward opening 112 while a downward opening of the dispensing probe 110 is dipped in the liquid. The dispensing device has a pressure vessel 120 in a manner where the upper end of the dispensing probe 110 is surrounded and the bottom inner surface 124a is located below the upward opening 112 of the dispensing probe 110, and makes the negative pressure of a syringe pump 30 act on the dispensing probe 110 via the pressure vessel 120. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a dispensing apparatus and a dispensing probe unit for dispensing a liquid such as a sample or a reagent.

  In an automatic analysis facility that analyzes a sample such as blood or urine, a dispensing device is applied when dispensing a predetermined amount of a sample and a reagent into a reaction container. As this type of dispensing device, one equipped with a dispensing probe is common. The dispensing probe is a tubular member configured in, for example, a thin cylindrical shape, and a base end portion thereof is connected to a syringe pump via an on-off valve.

  In the dispensing device configured as described above, the inside of the dispensing probe can be obtained by immersing the tip opening of the dispensing probe in a sample or reagent and sucking the piston of the syringe pump with the open / close valve opened. A sample or reagent can be aspirated into the sample (for example, see Patent Document 1).

  Here, in order to perform an accurate analysis in an automatic analysis facility, it is very important how to accurately dispense the sample and the reagent. For this reason, conventionally, the viscosity of the sample or reagent is determined by detecting the pressure of the syringe pump, and the operation of the syringe pump is controlled according to the determination result (see, for example, Patent Document 2). .

Japanese Patent Publication No. 2-29989 Japanese Patent Publication No. 3-40343

  By the way, in the dispensing apparatus described above, it is necessary to move the dispensing probe between the sample container and the reaction container and between the reagent container and the reaction container. For this reason, as a fluid conduit from the syringe pump to the dispensing probe, it is common to apply one formed by a flexible material.

  However, in a dispensing apparatus that applies a flexible fluid conduit from the syringe pump to the dispensing probe, even if the operation of the syringe pump is controlled according to the viscosity of the sample or reagent, Deformation due to pressure and changes over time cannot be prevented, and these effects make it difficult to accurately control the amount of sample or reagent dispensed.

  In view of the above circumstances, an object of the present invention is to provide a dispensing device and a dispensing probe unit that can perform accurate dispensing without being affected by pressure or change over time.

  In order to achieve the above object, a dispensing apparatus according to claim 1 of the present invention is provided with a dispensing probe having both ends opened, and the lower opening of the dispensing probe is immersed in a liquid. In a dispensing device that sucks liquid into the dispensing probe by applying a negative pressure from the opening of the portion, the upper end of the dispensing probe is surrounded, and the bottom inner surface is located above the dispensing probe. A pressure vessel is provided in such a manner as to be positioned below the opening of the part, and a negative pressure is applied to the dispensing probe via the pressure vessel.

  A dispensing apparatus according to a second aspect of the present invention is the dispensing apparatus according to the first aspect described above, wherein the upper opening of the dispensing probe can be positioned below the inner surface of the bottom of the pressure container. On the other hand, the dispensing probe is movably provided.

  The dispensing device according to claim 3 of the present invention is characterized in that, in claim 1 described above, the dispensing probe is detachably provided to the pressure vessel.

  A dispensing apparatus according to a fourth aspect of the present invention is characterized in that, in the above-described second or third aspect, the dispensing apparatus further comprises a washing water supply means for supplying washing water to the pressure vessel.

  The dispensing apparatus according to claim 5 of the present invention is the dispensing apparatus according to claim 1, further comprising liquid detection means for detecting that the liquid overflows from the upper opening of the dispensing probe. It is characterized by.

  The dispensing device according to claim 6 of the present invention is the dispensing device according to claim 5 described above, wherein the liquid detecting means is disposed at a position below the upper opening of the dispensing probe inside the pressure vessel. It is characterized by comprising a pair of provided electrodes and detecting whether or not the liquid overflows based on a change in electrical resistance value between these electrodes.

  The dispensing probe unit according to claim 7 of the present invention is a dispensing probe that sucks liquid into the interior when a negative pressure is applied from the other end opening while the one end opening is immersed in the liquid. The pressure probe is provided in such a manner that the other end portion of the dispensing probe surrounds the other end portion of the dispensing probe and the other end portion of the dispensing probe projects inward from the inner surface.

  The dispensing probe unit according to claim 8 of the present invention is the dispensing probe unit according to claim 7, wherein the other end opening of the dispensing probe protruding into the pressure vessel can be occupied below the inner surface of the pressure vessel. The dispensing probe is provided so as to be movable with respect to the pressure vessel.

  The dispensing probe unit according to claim 9 of the present invention is characterized in that, in the above-described claim 7, the dispensing probe is detachably provided to the pressure vessel.

  A dispensing probe unit according to a tenth aspect of the present invention is the pressure probe from the other end opening when the other end opening of the dispensing probe is arranged upward in the above-described seventh aspect. A liquid detecting means for detecting that the liquid overflows is provided.

  The dispensing probe unit according to an eleventh aspect of the present invention is the dispensing probe unit according to the tenth aspect, wherein the liquid detecting means is located closer to the inner surface than the other end opening of the dispensing probe inside the pressure vessel. And a pair of electrodes, and detecting whether or not the liquid overflows based on a change in electrical resistance value between these electrodes.

  According to the present invention, if a negative pressure is applied through the pressure vessel until the liquid overflows from the upper opening of the dispensing probe, a flexible fluid conduit to the dispensing probe is applied. Even in this case, a constant amount of liquid can always be sucked into the dispensing probe regardless of whether there is deformation due to pressure or change with time. For this reason, it becomes possible to dispense a sample and a reagent correctly, and it becomes possible to perform an exact analysis in an automatic analysis equipment.

  Exemplary embodiments of the present invention will be described below in detail with reference to the accompanying drawings.

  1 and 2 show a dispensing device and a dispensing probe unit according to an embodiment of the present invention. The dispensing probe unit 100 exemplified here is applied when dispensing a liquid such as a sample or a reagent in an automatic analysis facility, and includes a dispensing probe 110 and a pressure vessel 120.

  The dispensing probe 110 is formed of a material that is relatively hard and does not easily deform even when pressure is applied, such as glass, and is formed in a circular tube having a uniform cross section. In the present embodiment, as shown in FIG. 2, a plurality of types of dispensing probes 110 (a, b, c, d, e) having the same outer diameter d and different lengths are prepared. The plurality of dispensing probes 110 (a, b, c, d, e) are configured so that their internal volumes are equal to a plurality of dispensing amounts required in the automatic analysis facility. Further, each of the plurality of dispensing probes 110 (a, b, c, d, e) is provided with a protrusion 111 on each outer peripheral surface that is substantially the same from one end surface 112.

  The pressure vessel 120 is a hollow member having a sufficiently larger cross-sectional area than the dispensing probe 110, and has a pipe attachment hole 121 and a probe insertion hole 122. The pipe attachment hole 121 is an opening that communicates the inside and the outside in one end wall of the pressure vessel 120. A cylindrical pipe mounting portion 123 for mounting the fluid conduit 10 projects from a portion that becomes the opening peripheral portion of the pipe mounting hole 121. The probe insertion hole 122 is an opening that communicates the inside and the outside of the other end wall of the pressure vessel 120 and has an inner diameter that allows the dispensing probe 110 described above to be fitted and inserted therethrough.

  The pressure vessel 120 is provided with a bottom seat member 124 and a pair of electrodes 125 therein. The bottom seat member 124 is formed of an elastic material such as rubber and has a cross-sectional area that can be fitted inside the pressure vessel 120, and is arranged in close contact with the inner surface of the other end wall in which the probe insertion hole 122 is formed. It is set up. The bottom seat member 124 is provided with a probe mounting hole 126 at a site corresponding to the probe insertion hole 122. The probe mounting hole 126 is configured to have an inner diameter slightly smaller than the outer diameter d of the dispensing probe 110. When the dispensing probe 110 is inserted, the probe mounting hole 126 is in close contact with the outer peripheral surface, and is watertight between the dispensing probe 110. It is possible to ensure the sex. As clearly shown in FIG. 1, one end of the dispensing probe 110 is attached to the probe insertion hole 122 of the pressure vessel 120, and a preset gap is formed between the outer surface of the other end wall of the pressure vessel 120 and the protrusion 111. When in the secured state, the respective dimensions are set so that the one end surface 112 of the dispensing probe 110 protrudes further inward from the inner surface 124a of the bottom seat member 124 inside the pressure vessel 120. It is.

  The pair of electrodes 125 are arranged in such a manner that their respective distal ends are secured at a distance b (<a) from the inner surface 124a of the bottom seat member 124 and are separated from each other. Between the pair of electrodes 125, as shown in FIG. 2, a resistance value detector 130 is provided. The resistance value detection unit 130 detects an electrical resistance value between the pair of electrodes 125 and supplies the detection result to a dispensing control unit 140 described later.

  On the other hand, the pressure vessel 120 is provided with a fluid pipe line 10 provided with a three-way valve 20 in a pipe mounting portion 123. A syringe pump 30 is connected to one side of the three-way valve 20, and a cleaning pump 40 is connected to the other side of the three-way valve 20. The cleaning pump 40 is for supplying the cleaning liquid S stored in the cleaning liquid tank 50.

  FIG. 3 is a functional block diagram showing a control system of the dispensing apparatus described above. The dispensing control unit 140 shown in FIG. 3 is in accordance with a program and data stored in the memory 141 in advance, and further according to a detection result from the resistance value detection unit 130, a probe driving unit 142, a syringe driving unit 143, and a pump driving unit 144. By controlling the valve driving unit 145 in an integrated manner, the automatic dispensing equipment causes the dispensing device to perform a desired dispensing operation.

  The probe driving unit 142 moves the pressure vessel 120 along the vertical direction and the horizontal direction according to the drive signal given from the dispensing control unit 140, and is inserted into the probe insertion hole 122 of the pressure vessel 120. 110 is moved to a desired position, for example, a sample container position P1, a reaction container position P2, and a washing position P3. The syringe drive unit 143 operates the piston 31 of the syringe pump 30 according to the drive signal given from the dispensing control unit 140. The pump drive unit 144 drives the cleaning pump 40 in accordance with the drive signal given from the dispensing control unit 140. The valve driving unit 145 switches the three-way valve 20 in accordance with a driving signal given from the dispensing control unit 140.

  FIGS. 4-1 to 4-4 are conceptual diagrams sequentially illustrating the operation of the dispensing apparatus described above. Hereinafter, the control contents of the dispensing control unit 140 will be described with reference to these drawings as appropriate, and the characteristic portions of the dispensing device and the dispensing probe unit of the present invention will be described in detail.

  First, in the above-described dispensing device, the dispensing probe 110 is selected according to the required dispensing amount, and the selected dispensing probe 110 is attached to the probe insertion hole 122 of the pressure vessel 120. In this case, as described above, the dispensing probe 110 is mounted so that one end surface protrudes from the inner surface 124a of the bottom seat member 124 by the distance a, and the dispensing probe 110 is vertically downward from the other end surface of the pressure vessel 120. It is arranged in a manner extending.

  In this state, for example, when a sample dispensing command is given from the automatic analysis facility, the dispensing control unit 140 moves the dispensing probe 110 to the sample container position P1 via the probe driving unit 142, and FIG. As shown in FIG. 3, the lower end portion of the syringe is immersed in the sample T of the sample container 60, while the piston 31 of the syringe pump 30 is operated via the syringe drive unit 143, thereby causing the dispensing probe 110 to pass through the pressure vessel 120. Apply negative pressure. Furthermore, the dispensing control unit 140 monitors a change in the electrical resistance value between the pair of electrodes 125 via the resistance value detection unit 130.

  In the state shown in FIG. 4A, when a negative pressure is applied to the inside of the dispensing probe 110, the sample T in the sample container 60 is sequentially sucked into the dispensing probe 110, and thereafter, as shown in FIG. The sample T sucked beyond the internal volume of the injection probe 110 overflows into the pressure vessel 120. When the sample T overflowing from the inside of the pressure vessel 120 is stored from the inner surface 124a of the bottom seat member 124 to the height b, the electrical resistance value between the pair of electrodes 125 decreases, and this is detected by the resistance value detection unit 130. Will be.

  The dispensing control unit 140 that has confirmed that the electrical resistance value between the pair of electrodes 125 has become small based on the detection result from the resistance value detection unit 130 immediately stops the syringe pump 30 via the syringe drive unit 143. . As a result, in the dispensing apparatus, the inside of the dispensing probe 110 is filled with the sample T, while the sample T is stored in the pressure vessel 120 below the upper opening 112 of the dispensing probe 110. Become.

  The dispensing control unit 140 that has stopped the syringe pump 30 moves the dispensing probe 110 to the reaction container position P2 via the probe driving unit 142, and the lower end of the dispensing probe 110 is moved to the reaction container 70 as shown in FIG. Then, by operating the piston 31 of the syringe pump 30 via the syringe drive unit 143, air pressure is applied to the dispensing probe 110 via the pressure vessel 120. As a result, the sample T sucked from the sample container 60 is poured into the reaction container 70. In this case, if the air is sucked into the syringe pump 30 in advance and this air is included when the sample T is poured out, the sample T will be ejected vigorously, and the sample T will be discharged to the dispensing probe 110. Can be prevented from remaining. This method is more effective as the dispensing amount is smaller.

  Here, according to the above dispensing device, the upper opening 112 of the dispensing probe 110 is located above the liquid level of the sample T stored in the pressure vessel 120, so that the operation amount of the syringe pump 30 is reduced. Regardless, only the sample T that has filled the dispensing probe 110 is poured into the reaction vessel 70, and the sample T that overflows from the dispensing probe 110 and is stored in the pressure vessel 120 remains as it is in the pressure vessel 120. You will stay inside. That is, only the sample T equal to the internal volume of the dispensing probe 110 is poured out into the reaction container 70. Moreover, the amount of the sample T that is dispensed from the dispensing probe 110 is determined by its internal volume, and is affected no matter how the fluid conduit 10 connected to the syringe pump 30 is deformed. There is nothing. Accordingly, even when a flexible fluid conduit 10 is applied, a constant amount of liquid is always sucked into the dispensing probe 110 regardless of whether there is deformation due to pressure or changes with time. This can be dispensed into the reaction vessel 70, and an accurate analysis can be performed in an automatic analysis facility.

  The dispensing control unit 140 that has finished dispensing the sample T into the reaction vessel 70 moves the dispensing probe 110 to the cleaning position P3 via the probe driving unit 142. First, the protrusion 111 is placed on a hooking rod (not shown). By engaging, the dispensing probe 110 is removed from the pressure vessel 120. Thereafter, as shown in FIG. 4-4, the dispensing control unit 140 drives the cleaning pump 40 via the pump drive unit 144 and supplies the cleaning liquid S stored in the cleaning liquid tank 50 to the inside of the pressure vessel 120. To do. As a result, the portion of the pressure vessel 120 in contact with the sample T can be washed, and the washed washing liquid S can be discharged to the washing vessel 80. The dispensing probe 110 extracted from the pressure vessel 120 may be discarded as it is, or may be separately washed and reused.

  Hereinafter, by repeatedly performing the above-described operation, the sample T in the sample container 60 can be accurately dispensed into the reaction container 70 in the automatic analysis facility. When changing the dispensing amount, the dispensing probe 110 having an internal volume equal to the dispensing amount after the change may be replaced with the pressure vessel 120.

  As described above, according to the above dispensing apparatus, if a negative pressure is applied via the pressure vessel 120 until the sample T overflows from the upper opening 112 of the dispensing probe 110, the fluid reaching the dispensing probe 110 is reached. Even when a flexible pipe 10 is applied, a constant amount of liquid can always be sucked into the dispensing probe 110 regardless of deformation due to pressure or changes over time. It becomes. For this reason, it becomes possible to dispense liquids, such as sample T correctly, and it becomes possible to perform an exact analysis in automatic analysis equipment. In this case, regarding the driving of the syringe pump 30, no severe control is required for the movement amount of the piston 31, and a negative pressure is simply applied until the sample T overflows from the upper opening 112 of the dispensing probe 110. Therefore, for example, the syringe pump 30 can be controlled by the driving time.

  In the above-described embodiment, the dispensing probe 110 is detachably arranged with respect to the pressure vessel 120, and the dispensing probe 110 is removed when the pressure vessel 120 is washed. It is not necessary, and it is sufficient if the upper opening of the dispensing probe can move below the inner surface of the bottom of the pressure vessel when cleaning the pressure vessel.

  5 to 7 show modified examples of the dispensing probe unit 100 shown in the embodiment. In the dispensing probe unit 100 ′ of this modification, a convex portion 127 is provided on the pressure vessel 120 ′, while a cup member 115 is attached to the dispensing probe 110. The convex portion 127 is a single annular portion provided on the outer peripheral surface of the other end portion of the pressure vessel 120 ′. The cup member 115 is a bottomed cylindrical member formed in a size that can be attached to the outer periphery of the other end of the pressure vessel 120 ′, and a dispensing probe 110 ′ is fixed to the center of the bottom wall. . The cup member 115 is provided with two concave grooves 116 and 117. The two concave grooves 116 and 117 are each an annular concave portion that can accommodate the convex portion 127 of the pressure vessel 120 ′, and are arranged in parallel to the cup member 115 in a manner along the axial center of the dispensing probe 110 ′. It is. As is apparent from the figure, when the convex portion 127 of the pressure vessel 120 ′ is aligned with the concave groove 117 formed below the cup member 115, the one end surface 112 of the dispensing probe 110 ′ is fixed to the pressure vessel 120 ′. 7 protrudes inwardly from the inner surface 124a of the bottom seat member 124 by a distance a while the convex portion 127 is aligned with the concave groove 116 formed above the cup member 115. FIG. As shown in FIG. 4, the dimensions are set so that the one end surface 112 of the dispensing probe 110 ′ is equal to or smaller than the inner surface 124 a of the bottom seat member 124.

  In this modification as well, the dispensing probe 110 'is formed of a material such as glass that is relatively hard and does not easily deform even when pressure is applied. Also, a plurality of types of dispensing probes 110 ′ having the same outer diameter d and different lengths are prepared as in the above-described embodiment. Other configurations similar to those in the embodiment are denoted by the same reference numerals, and detailed descriptions thereof are omitted.

  Also in this modified example, first, a dispensing probe 110 ′ is selected according to a required dispensing amount, and the selected dispensing probe 110 ′ is attached to the probe insertion hole 122 of the pressure vessel 120 ′. Become. In this case, as shown in FIG. 5, a pressure vessel is formed in a concave groove 117 formed below the cup member 115 so that the one end surface 112 of the dispensing probe 110 ′ protrudes from the inner surface 124a of the bottom seat member 124 by a distance a. Dispensing probe 110 'is mounted in such a manner as to match convex portion 127 of 120', and dispensing probe 110 'is arranged in a manner that extends vertically downward from the other end surface of pressure vessel 120'.

  In this state, the dispensing probe unit 100 ′ of the modified example has the same configuration as that of the above-described embodiment. Therefore, by performing the same operation as in FIGS. It is possible to accurately perform the suction of the sample T and the extraction of the sample T into the reaction vessel 70.

  On the other hand, after the dispensing of the sample T into the reaction container 70 is completed, the dispensing probe 110 ′ is moved to the cleaning position P3 via the probe driving unit 142, and from this state, the protrusion 111 is formed on the hooking rod (not shown). 7, as shown in FIG. 7, the dispensing probe 110 ′ is slid so that the convex portion 127 of the pressure vessel 120 ′ is aligned with the concave groove 116 formed above the cup member 115. . In this state, when the cleaning pump 40 is driven via the pump driving unit 144 and the cleaning liquid S stored in the cleaning liquid tank 50 is supplied to the inside of the pressure vessel 120 ′, the sample T comes into contact with the inside of the pressure vessel 120 ′. And the portion of the dispensing probe 110 ′ that is in contact with the sample T can be cleaned. Even when the pressure vessel 120 ′ and the dispensing probe 110 ′ are used repeatedly, the problem of contamination is eliminated. There is no fear of being invited.

  Also in this modified example, if a negative pressure is applied through the pressure vessel 120 ′ until the sample T overflows from the upper opening 112 of the dispensing probe 110 ′, the fluid conduit 10 leading to the dispensing probe 110 ′ is possible. Even when a material having flexibility is applied, a constant amount of liquid can always be sucked into the dispensing probe 110 ′ regardless of the presence or absence of deformation or change with time. For this reason, it becomes possible to dispense liquids, such as sample T correctly, and it becomes possible to perform an exact analysis in automatic analysis equipment. In this case, regarding the driving of the syringe pump 30, no severe control is required for the moving amount of the piston 31, and a negative pressure is simply applied until the sample T overflows from the upper opening 112 of the dispensing probe 110 '. For example, the syringe pump 30 can even be controlled by the driving time.

  In the embodiment and the modification described above, the sample T is dispensed. However, the present invention can also be applied to other liquid dispensers such as a specimen and a reagent.

  Further, in the above-described embodiment and modification, it is detected that the liquid overflows from the upper opening 112 of the dispensing probe 110, 110 'to the pressure vessel 120, 120'. Although T can be reduced as much as possible, it is not always necessary to provide means for detecting the liquid. In the embodiment and the modification described above when the liquid detection unit is provided, when the electrical resistance value between the pair of electrodes 125 changes, the pressure vessel 120 from the upper opening 112 of the dispensing probes 110 and 110 ′. , 120 'is detected as overflowing liquid, but the present invention is not limited to this. For example, an optical sensor or electrostatic sensor is applied to detect that liquid overflows. Is also possible. Further, an optical sensor or an electrostatic sensor for detecting the liquid is not necessarily provided inside the pressure vessel 120 ′.

  Further, in the above-described embodiment and modification, the bottom seat member 124 is provided inside the pressure vessel 120, 120 ′, and the upper surface of the dispensing probe 110, 110 ′ is opened with the inner surface 124a of the bottom seat member 124 as the bottom inner surface. Although the position of 112 is defined, the bottom seat member 124 is not necessarily provided. In this case, what is necessary is just to prescribe | regulate the position of the upper part opening 112 of dispensing probe 110,110 'on the basis of the bottom part inner surface of pressure vessel 120,120'.

It is a conceptual diagram which shows the dispensing apparatus which is embodiment of this invention. It is a disassembled sectional view of the dispensing probe unit applied to the dispensing apparatus shown in FIG. It is a functional block diagram which shows the control system of the dispensing apparatus shown in FIG. It is a conceptual diagram which shows operation | movement of the dispensing apparatus shown in FIG. It is a conceptual diagram which shows operation | movement of the dispensing apparatus shown in FIG. It is a conceptual diagram which shows operation | movement of the dispensing apparatus shown in FIG. It is a conceptual diagram which shows operation | movement of the dispensing apparatus shown in FIG. It is a conceptual diagram which shows the modification of the dispensing apparatus shown in FIG. It is a disassembled sectional view of the dispensing probe unit applied to the dispensing apparatus shown in FIG. It is a conceptual diagram which shows operation | movement of the dispensing apparatus shown in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Fluid pipe line 20 Three-way valve 30 Syringe pump 31 Piston 40 Cleaning pump 50 Cleaning liquid tank 60 Sample container 70 Reaction container 80 Cleaning container 100,100 'Dispensing probe unit 110,110' Dispensing probe 111 Protrusion 112 One end surface 112 Above Part opening 115 cup member 116, 117 concave groove 120, 120 'pressure vessel 121 pipe mounting hole 122 probe insertion hole 123 pipe mounting part 124 bottom seat member 124a inner surface 125 of base seat member 126 electrode mounting hole 127 convex part 130 resistance value detection Unit 140 dispensing control unit 141 memory 142 probe driving unit 143 syringe driving unit 144 pump driving unit 145 valve driving unit T sample

Claims (11)

A dispensing probe having both ends opened is provided, and a liquid is sucked into the dispensing probe by applying a negative pressure from the upper opening while the lower opening of the dispensing probe is immersed in the liquid. In such a dispensing device,
A pressure vessel is provided so as to surround the upper end portion of the dispensing probe and the bottom inner surface is located below the upper opening of the dispensing probe, and a negative pressure is applied to the dispensing probe through the pressure vessel. A dispensing device characterized in that   2. The dispensing probe is provided so as to be movable with respect to the pressure vessel in such a manner that an upper opening of the dispensing probe can be occupied below an inner surface of a bottom portion of the pressure vessel. Dispensing device.   The dispensing apparatus according to claim 1, wherein the dispensing probe is detachably provided to the pressure vessel.   The dispensing apparatus according to claim 2 or 3, further comprising cleaning water supply means for supplying cleaning water to the pressure vessel.   2. The dispensing apparatus according to claim 1, further comprising a liquid detection unit configured to detect that the liquid overflows from the upper opening of the dispensing probe into the pressure vessel.   The liquid detection means includes a pair of electrodes disposed in a position below the upper opening of the dispensing probe inside the pressure vessel, and the liquid is detected based on a change in electrical resistance value between the electrodes. 6. The dispensing apparatus according to claim 5, wherein the dispensing apparatus detects whether the overflow has occurred. In a dispensing probe unit equipped with a dispensing probe that sucks liquid inside when a negative pressure is applied from the other end opening with the one end opening immersed in the liquid,
A dispensing probe unit characterized in that a pressure vessel is provided so as to surround the other end portion of the dispensing probe and to project the other end portion of the dispensing probe from the inner surface to the inside.   The dispensing probe is movably provided with respect to the pressure vessel in such a manner that the other end opening of the dispensing probe protruding into the pressure vessel can be occupied below the inner surface of the pressure vessel. The dispensing probe unit according to claim 7.   The dispensing probe unit according to claim 7, wherein the dispensing probe is detachably provided to the pressure vessel.   8. A liquid detecting means is provided for detecting that the liquid overflows from the other end opening when the other end opening of the dispensing probe is disposed upward. The dispensing probe unit described in 1.   The liquid detecting means includes a pair of electrodes in a portion closer to the inner surface than the other end opening of the dispensing probe inside the pressure vessel, and whether liquid has overflowed based on a change in electrical resistance value between these electrodes. The dispensing probe unit according to claim 10, which detects whether or not.

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